CCK1 receptor - Gs

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Homo sapiens

PDB CODE

9BKK

RESOLUTION

2.5 Å

REFERENCE

10.1371/JOURNAL.PBIO.3002673

PUBLICATION DATE

May 22, 2024

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

72 interactions (Click to see)

LIGANDS

CHEMBL216166 - Agonist chembl_ligand pubchem

PHYSIOLOGICAL LIGANDS

CCK-8, desulfated cholecystokinin-8, CCK-39, CCK-58, CCK-33, CCK-4, gastrin-17



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar H8 N 374 8x47 G.H5 N 392 G.H5.24
Hydrophobic H8 N 374 8x47 G.H5 N 392 G.H5.24
Van-der-waals H8 N 374 8x47 G.H5 N 392 G.H5.24
Hydrophobic TM6 V 311 6x33 G.H5 V 394 G.H5.26
Hydrophobic TM6 V 311 6x33 G.H5 L 393 G.H5.25
Hydrophobic ICL2 R 150 - G.S1 L 41 G.S1.02
Hydrophobic ICL2 L 147 - G.H5 I 383 G.H5.15
Hydrophobic ICL2 L 147 - G.H5 K 380 G.H5.12
Van-der-waals ICL2 L 147 - G.H5 K 380 G.H5.12
Hydrophobic ICL2 P 146 - G.H5 K 380 G.H5.12
Polar TM3 R 139 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM3 R 139 3x50 G.H5 Y 391 G.H5.23
Van-der-waals TM3 R 139 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM5 L 236 5x65 G.H5 L 388 G.H5.20
Ionic H8 R 376 8x49 G.H5 E 390 G.H5.22
Polar H8 R 376 8x49 G.H5 E 390 G.H5.22
Hydrophobic H8 R 376 8x49 G.H5 E 390 G.H5.22
Van-der-waals H8 R 376 8x49 G.H5 E 390 G.H5.22
Hydrophobic ICL2 L 147 - G.S3 V 217 G.S3.01
Polar TM2 N 77 2x40 G.H5 N 392 G.H5.24
Van-der-waals TM2 N 77 2x40 G.H5 N 392 G.H5.24
Polar TM2 T 74 2x37 G.H5 E 390 G.H5.22
Hydrophobic TM2 T 74 2x37 G.H5 E 390 G.H5.22
Polar ICL2 Q 153 - G.H5 Y 391 G.H5.23
Hydrophobic ICL2 Q 153 - G.H5 Y 391 G.H5.23
Van-der-waals ICL2 Q 153 - G.H5 Y 391 G.H5.23
Polar TM7 Y 370 7x53 G.H5 N 392 G.H5.24
Polar ICL2 R 150 - G.S1 T 40 G.S1.01
Hydrophobic TM3 A 142 3x53 G.H5 Y 391 G.H5.23
Van-der-waals TM3 A 142 3x53 G.H5 Y 391 G.H5.23
Hydrophobic TM3 I 143 3x54 G.H5 L 393 G.H5.25
Van-der-waals TM3 I 143 3x54 G.H5 L 393 G.H5.25
Hydrophobic TM4 T 154 4x38 G.hns1 R 38 G.hns1.02
Van-der-waals TM4 T 154 4x38 G.hns1 R 38 G.hns1.02
Hydrophobic TM3 I 143 3x54 G.H5 L 388 G.H5.20
Van-der-waals TM3 I 143 3x54 G.H5 L 388 G.H5.20
Polar TM3 R 139 3x50 G.H5 N 392 G.H5.24
Hydrophobic ICL2 P 146 - G.H5 I 383 G.H5.15
Van-der-waals ICL2 P 146 - G.H5 I 383 G.H5.15
Hydrophobic TM2 T 76 2x39 G.H5 Y 391 G.H5.23
Hydrophobic TM2 T 76 2x39 G.H5 N 392 G.H5.24
Hydrophobic ICL2 L 147 - G.S1 L 41 G.S1.02
Polar ICL2 R 150 - G.hns1 R 38 G.hns1.02
Van-der-waals ICL2 R 150 - G.hns1 R 38 G.hns1.02
Hydrophobic TM3 E 138 3x49 G.H5 Y 391 G.H5.23
Polar TM3 A 142 3x53 G.H5 N 387 G.H5.19
Hydrophobic TM3 A 142 3x53 G.H5 N 387 G.H5.19
Van-der-waals TM3 A 142 3x53 G.H5 N 387 G.H5.19
Hydrophobic TM3 I 143 3x54 G.H5 N 387 G.H5.19
Hydrophobic TM6 L 315 6x37 G.H5 L 393 G.H5.25
Polar ICL2 V 151 - G.hns1 R 38 G.hns1.02
Van-der-waals ICL2 V 151 - G.hns1 R 38 G.hns1.02
Hydrophobic TM2 T 76 2x39 G.H5 E 390 G.H5.22
Van-der-waals TM2 T 76 2x39 G.H5 E 390 G.H5.22
Hydrophobic TM3 I 143 3x54 G.H5 L 384 G.H5.16
Van-der-waals TM3 I 143 3x54 G.H5 L 384 G.H5.16
Van-der-waals TM2 L 80 2x43 G.H5 N 392 G.H5.24
Hydrophobic ICL2 P 146 - G.H5 L 384 G.H5.16
Polar H8 R 376 8x49 G.H5 R 389 G.H5.21
Hydrophobic H8 R 376 8x49 G.H5 R 389 G.H5.21
Van-der-waals H8 R 376 8x49 G.H5 R 389 G.H5.21
Hydrophobic TM3 R 139 3x50 G.H5 L 393 G.H5.25
Hydrophobic ICL2 V 151 - G.hns1 R 39 G.hns1.03
Van-der-waals ICL2 V 151 - G.hns1 R 39 G.hns1.03