μ receptor - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Mus musculus

GPCR PREFERRED CHAIN

D

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

3.3 Å

REFERENCE

PUBLICATION DATE

Sept. 11, 2024

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

LIGANDS

N-[[3-(hydroxymethyl)phenyl]methyl]-N-[1-(2-phenylethyl)piperidin-4-yl]propanamide - Agonist pubchem

PHYSIOLOGICAL LIGANDS

No physiological ligands available



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

, , , GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type
GPCR
Segment

AA

Number
Generic
number

segment

AA

Number
Generic
number
Hydrophobic ICL3 M 264 - G.H5 K 345 G.H5.17
Hydrophobic ICL2 V 173 34x51 G.H5 F 336 G.H5.08
Hydrophobic TM5 M 255 5x61 G.H5 L 353 G.H5.25
Hydrophobic ICL3 M 264 - G.h4s6 T 316 G.h4s6.10
Van-der-waals ICL3 M 264 - G.h4s6 T 316 G.h4s6.10
Hydrophobic ICL2 P 172 34x50 G.H5 I 344 G.H5.16
Hydrophobic ICL3 L 265 - G.H5 L 348 G.H5.20
Hydrophobic TM3 R 165 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 165 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 165 3x50 G.H5 L 353 G.H5.25
Ionic ICL2 D 177 34x55 G.hns1 R 32 G.hns1.03
Polar ICL2 D 177 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 D 177 34x55 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 D 177 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic TM3 V 169 3x54 G.H5 L 348 G.H5.20
Polar H8 E 341 8x48 G.H5 G 352 G.H5.24
Hydrophobic H8 E 341 8x48 G.H5 G 352 G.H5.24
Van-der-waals H8 E 341 8x48 G.H5 G 352 G.H5.24
Polar TM3 A 168 3x53 G.H5 N 347 G.H5.19
Hydrophobic ICL2 P 172 34x50 G.H5 T 340 G.H5.12
Hydrophobic TM5 L 259 5x65 G.H5 L 348 G.H5.20
Van-der-waals TM5 L 259 5x65 G.H5 L 348 G.H5.20
Polar ICL3 R 263 - G.S6 I 319 G.S6.01
Van-der-waals ICL3 R 263 - G.S6 I 319 G.S6.01
Polar TM6 R 277 6x32 G.H5 L 353 G.H5.25
Hydrophobic H8 D 340 8x47 G.H5 G 352 G.H5.24
Van-der-waals H8 D 340 8x47 G.H5 G 352 G.H5.24
Hydrophobic TM5 R 258 5x64 G.H5 I 344 G.H5.16
Van-der-waals TM5 R 258 5x64 G.H5 I 344 G.H5.16
Hydrophobic ICL2 L 176 34x54 G.H5 I 343 G.H5.15
Hydrophobic ICL2 L 176 34x54 G.S3 L 194 G.S3.01
Hydrophobic ICL2 P 172 34x50 G.H5 I 343 G.H5.15
Van-der-waals ICL2 P 172 34x50 G.H5 I 343 G.H5.15
Hydrophobic ICL3 R 263 - G.S6 Y 320 G.S6.02
Polar TM6 R 277 6x32 G.H5 F 354 G.H5.26
Hydrophobic TM6 I 278 6x33 G.H5 F 354 G.H5.26
Van-der-waals TM6 I 278 6x33 G.H5 F 354 G.H5.26
Hydrophobic TM6 N 274 6x29 G.H5 F 354 G.H5.26