ACKR3 - Beta-arrestin-1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

ARRESTIN (FAMILY)

Beta

ARRESTIN

Beta-arrestin-1

ARRESTIN SPECIES

Bovine

ARRESTIN CHAIN

A

ARRESTIN COVERAGE

81

PDB CODE

9E82

RESOLUTION

3.4 Å

REFERENCE

10.1038/S41586-025-09024-9

PUBLICATION DATE

April 2, 2025

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

55 interactions (Click to see)

LIGANDS

SDF-1-beta(3-72) - Agonist

PHYSIOLOGICAL LIGANDS

CXCL12α (Human), CXCL11 (Human)



GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic TM6 I 253 6x36 s15s16 F 244 C.s15s16.03
Van-der-waals TM6 I 253 6x36 s15s16 F 244 C.s15s16.03
Polar C-term L 314 - s15s16 T 246 C.s15s16.05
Polar C-term S 316 - S15 I 241 C.S15.14
Hydrophobic C-term S 316 - S15 I 241 C.S15.14
Van-der-waals C-term S 316 - S15 I 241 C.S15.14
Hydrophobic C-term K 342 - ns1 T 6 N.ns1.14
Van-der-waals C-term K 342 - ns1 T 6 N.ns1.14
Polar C-term G 339 - S1 K 10 N.S1.03
Hydrophobic C-term G 339 - S1 K 10 N.S1.03
Van-der-waals C-term G 339 - S1 K 10 N.S1.03
Hydrophobic C-term K 337 - S1 K 11 N.S1.04
Van-der-waals C-term K 337 - S1 K 11 N.S1.04
Hydrophobic TM1 W 67 1x55 S16 C 251 C.S16.05
Van-der-waals TM1 W 67 1x55 S16 C 251 C.S16.05
Hydrophobic C-term L 340 - ns1 R 7 N.ns1.15
Van-der-waals C-term L 340 - ns1 R 7 N.ns1.15
Hydrophobic C-term Y 315 - s15s16 N 245 C.s15s16.04
Van-der-waals C-term Y 315 - s15s16 N 245 C.s15s16.04
Polar C-term L 343 - ns1 T 6 N.ns1.14
Hydrophobic C-term Y 315 - s15s16 T 246 C.s15s16.05
Van-der-waals C-term Y 315 - s15s16 T 246 C.s15s16.05
Hydrophobic TM6 I 253 6x36 s15s16 N 245 C.s15s16.04
Van-der-waals TM6 I 253 6x36 s15s16 N 245 C.s15s16.04
Hydrophobic C-term Y 322 - s17s18 R 285 C.s17s18.11
Van-der-waals C-term Y 322 - s17s18 R 285 C.s17s18.11
Polar TM1 N 69 1x57 S16 K 250 C.S16.04
Hydrophobic TM1 N 69 1x57 S16 K 250 C.S16.04
Van-der-waals TM1 N 69 1x57 S16 K 250 C.S16.04
Hydrophobic C-term S 316 - S16 A 247 C.S16.01
Van-der-waals C-term S 316 - S16 A 247 C.S16.01
Hydrophobic TM6 R 251 6x34 s15s16 F 244 C.s15s16.03
Hydrophobic TM1 W 67 1x55 s17s18 K 284 C.s17s18.10
Van-der-waals TM1 W 67 1x55 s17s18 K 284 C.s17s18.10
Polar C-term R 320 - s17s18 G 286 C.s17s18.12
Hydrophobic C-term R 320 - s17s18 G 286 C.s17s18.12
Van-der-waals C-term R 320 - s17s18 G 286 C.s17s18.12
Hydrophobic C-term Y 315 - S16 A 247 C.S16.01
Van-der-waals C-term Y 315 - S16 A 247 C.S16.01
Hydrophobic C-term L 314 - s15s16 N 245 C.s15s16.04
Van-der-waals C-term L 314 - s15s16 N 245 C.s15s16.04
Polar C-term S 316 - S16 Y 249 C.S16.03
Hydrophobic C-term S 316 - S16 Y 249 C.S16.03
Van-der-waals C-term S 316 - S16 Y 249 C.S16.03
Polar TM1 V 68 1x56 S16 K 250 C.S16.04
Hydrophobic TM1 V 68 1x56 S16 K 250 C.S16.04
Van-der-waals TM1 V 68 1x56 S16 K 250 C.S16.04
Hydrophobic C-term R 320 - S16 C 251 C.S16.05
Van-der-waals C-term R 320 - S16 C 251 C.S16.05
Hydrophobic TM1 I 70 1x58 S16 K 250 C.S16.04
Van-der-waals TM1 I 70 1x58 S16 K 250 C.S16.04
Hydrophobic C-term I 318 - S15 I 241 C.S15.14
Van-der-waals C-term I 318 - S15 I 241 C.S15.14
Polar TM7 V 313 7x51 s15s16 N 245 C.s15s16.04
Van-der-waals TM7 V 313 7x51 s15s16 N 245 C.s15s16.04
Hydrophobic C-term L 343 - H1 R 103 N.H1.05
Hydrophobic C-term L 343 - H1 K 107 N.H1.09
Hydrophobic C-term K 342 - ns1 R 7 N.ns1.15
Polar TM1 I 70 1x58 S15 R 236 C.S15.09
Van-der-waals TM1 I 70 1x58 S15 R 236 C.S15.09
Hydrophobic C-term I 318 - S8 L 129 N.S8.03
Hydrophobic TM6 K 252 6x35 s15s16 F 244 C.s15s16.03
Polar C-term R 320 - S16 K 250 C.S16.04
Polar TM4 R 162 4x43 s18s19 S 340 C.s18s19.11
Hydrophobic TM4 R 162 4x43 s18s19 S 340 C.s18s19.11
Van-der-waals TM4 R 162 4x43 s18s19 S 340 C.s18s19.11
Hydrophobic C-term K 342 - S1 V 8 N.S1.01
Hydrophobic C-term I 318 - S16 Y 249 C.S16.03
Van-der-waals C-term I 318 - S16 Y 249 C.S16.03
Hydrophobic C-term R 320 - s17s18 R 285 C.s17s18.11
Van-der-waals C-term R 320 - s17s18 R 285 C.s17s18.11
Hydrophobic C-term L 340 - S1 F 9 N.S1.02
Van-der-waals C-term L 340 - S1 F 9 N.S1.02
Hydrophobic TM1 V 68 1x56 S16 Y 249 C.S16.03
Van-der-waals TM1 V 68 1x56 S16 Y 249 C.S16.03