Rhodopsin - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Hasarius adansoni

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

9EPP

RESOLUTION

4.1 Å

REFERENCE

PUBLICATION DATE

Oct. 23, 2024

3D VIEW

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LIGAND INTERACTIONS

22 interactions (Click to see)

LIGANDS

11,20-Ethanoretinal - Agonist pubchem

PHYSIOLOGICAL LIGANDS

No physiological ligands available



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM5 H 244 5x68 G.H5 D 341 G.H5.13
Aromatic ICL3 R 261 - G.S6 Y 320 G.S6.02
Hydrophobic TM5 M 255 5x79 G.S6 H 322 G.S6.04
Van-der-waals TM5 M 255 5x79 G.S6 H 322 G.S6.04
Polar TM3 R 148 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 148 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM5 I 237 5x61 G.H5 L 353 G.H5.25
Hydrophobic TM3 R 148 3x50 G.H5 L 353 G.H5.25
Van-der-waals TM3 R 148 3x50 G.H5 L 353 G.H5.25
Polar TM5 Q 251 5x75 G.H5 Q 333 G.H5.05
Hydrophobic TM5 Q 251 5x75 G.H5 Q 333 G.H5.05
Van-der-waals TM5 Q 251 5x75 G.H5 Q 333 G.H5.05
Polar ICL2 A 157 - G.hns1 R 31 G.hns1.02
Ionic ICL3 R 261 - G.H5 D 341 G.H5.13
Polar ICL3 R 261 - G.H5 D 341 G.H5.13
Hydrophobic ICL3 R 261 - G.H5 D 341 G.H5.13
Van-der-waals ICL3 R 261 - G.H5 D 341 G.H5.13
Ionic H8 K 337 8x49 G.H5 E 350 G.H5.22
Polar H8 K 337 8x49 G.H5 E 350 G.H5.22
Van-der-waals H8 K 337 8x49 G.H5 E 350 G.H5.22
Hydrophobic TM5 H 244 5x68 G.H5 K 340 G.H5.12
Van-der-waals TM5 H 244 5x68 G.H5 K 340 G.H5.12
Van-der-waals ICL3 N 263 - G.h4s6 E 318 G.h4s6.12
Polar TM6 R 274 6x32 G.H5 V 354 G.H5.26
Hydrophobic TM6 R 274 6x32 G.H5 V 354 G.H5.26
Van-der-waals TM6 R 274 6x32 G.H5 V 354 G.H5.26
Polar ICL3 S 262 - G.S6 I 319 G.S6.01
Hydrophobic ICL3 S 262 - G.S6 I 319 G.S6.01
Van-der-waals ICL3 S 262 - G.S6 I 319 G.S6.01
Polar ICL2 M 156 - G.hns1 R 31 G.hns1.02
Hydrophobic ICL2 M 156 - G.hns1 R 31 G.hns1.02
Van-der-waals ICL2 M 156 - G.hns1 R 31 G.hns1.02
Polar ICL3 S 262 - G.H4 E 308 G.H4.16
Hydrophobic ICL3 S 262 - G.H4 E 308 G.H4.16
Van-der-waals ICL3 S 262 - G.H4 E 308 G.H4.16
Ionic ICL3 R 261 - G.h4s6 E 318 G.h4s6.12
Polar ICL3 R 261 - G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL3 R 261 - G.h4s6 E 318 G.h4s6.12
Van-der-waals ICL3 R 261 - G.h4s6 E 318 G.h4s6.12
Hydrophobic TM3 I 152 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 I 152 3x54 G.H5 L 348 G.H5.20
Hydrophobic TM5 H 244 5x68 G.H5 L 344 G.H5.16
Hydrophobic TM6 L 275 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 L 275 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM3 I 152 3x54 G.H5 N 347 G.H5.19
Van-der-waals TM3 I 152 3x54 G.H5 N 347 G.H5.19
Hydrophobic TM6 V 278 6x36 G.H5 L 353 G.H5.25
Van-der-waals TM6 V 278 6x36 G.H5 L 353 G.H5.25
Hydrophobic TM3 V 151 3x53 G.H5 C 351 G.H5.23
Van-der-waals TM3 V 151 3x53 G.H5 C 351 G.H5.23
Hydrophobic TM6 V 278 6x36 G.H5 V 354 G.H5.26
Hydrophobic TM3 I 152 3x54 G.H5 C 351 G.H5.23
Polar H8 H 335 8x47 G.H5 N 352 G.H5.24
Hydrophobic H8 H 335 8x47 G.H5 N 352 G.H5.24
Van-der-waals H8 H 335 8x47 G.H5 N 352 G.H5.24
Hydrophobic TM5 M 255 5x79 G.H5 K 330 G.H5.02
Polar TM7 S 334 7x56 G.H5 N 352 G.H5.24
Hydrophobic TM7 S 334 7x56 G.H5 N 352 G.H5.24
Van-der-waals TM7 S 334 7x56 G.H5 N 352 G.H5.24
Polar TM5 Q 251 5x75 G.H5 C 337 G.H5.09
Hydrophobic TM5 Q 251 5x75 G.H5 C 337 G.H5.09
Van-der-waals TM5 Q 251 5x75 G.H5 C 337 G.H5.09
Hydrophobic TM5 M 255 5x79 G.s6h5 C 325 G.s6h5.02
Van-der-waals TM5 M 255 5x79 G.s6h5 C 325 G.s6h5.02
Hydrophobic ICL2 M 156 - G.hns1 R 32 G.hns1.03
Hydrophobic ICL3 L 260 - G.H5 F 334 G.H5.06
Van-der-waals ICL3 L 260 - G.H5 F 334 G.H5.06