TAS2R14 - Gi1

GPCR CLASS (FAMILY)

Class T2 (Taste 2)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

9IJ9

RESOLUTION

2.7 Å

REFERENCE

PUBLICATION DATE

July 24, 2024

3D VIEW

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LIGAND INTERACTIONS

32 interactions (Click to see)

LIGANDS

Cholesterol - Agonist pubchem ,

compound 28.1 [PMID: 36847646] - Allosteric agonist pubchem gtoplig chembl_ligand

PHYSIOLOGICAL LIGANDS

No physiological ligands available



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL3 K 225 - G.H5 K 345 G.H5.17
Hydrophobic TM3 I 111 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 I 111 3x54 G.H5 L 348 G.H5.20
Hydrophobic ICL3 V 216 - G.S6 Y 320 G.S6.02
Hydrophobic ICL2 N 113 - G.H5 I 344 G.H5.16
Polar ICL3 T 224 - G.H5 K 345 G.H5.17
Hydrophobic ICL3 T 224 - G.H5 K 345 G.H5.17
Van-der-waals ICL3 T 224 - G.H5 K 345 G.H5.17
Ionic TM5 K 211 5x71 G.H5 D 337 G.H5.09
Polar TM5 K 211 5x71 G.H5 D 337 G.H5.09
Hydrophobic TM5 K 211 5x71 G.H5 D 337 G.H5.09
Van-der-waals TM5 K 211 5x71 G.H5 D 337 G.H5.09
Polar ICL3 S 223 - G.h4s6 D 315 G.h4s6.09
Hydrophobic ICL3 S 223 - G.h4s6 D 315 G.h4s6.09
Polar ICL3 A 222 - G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL3 A 222 - G.h4s6 E 318 G.h4s6.12
Van-der-waals ICL3 A 222 - G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL3 T 224 - G.h4s6 D 315 G.h4s6.09
Van-der-waals ICL3 T 224 - G.h4s6 D 315 G.h4s6.09
Aromatic ICL2 W 124 - G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 W 124 - G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 W 124 - G.hns1 R 32 G.hns1.03
Hydrophobic TM3 Y 107 3x50 G.H5 L 353 G.H5.25
Ionic TM3 K 110 3x53 G.H5 D 350 G.H5.22
Polar TM3 K 110 3x53 G.H5 D 350 G.H5.22
Van-der-waals TM3 K 110 3x53 G.H5 D 350 G.H5.22
Hydrophobic TM5 M 205 5x65 G.H5 I 344 G.H5.16
Hydrophobic TM3 I 111 3x54 G.H5 I 344 G.H5.16
Van-der-waals TM3 I 111 3x54 G.H5 I 344 G.H5.16
Polar TM5 T 215 5x75 G.H5 D 337 G.H5.09
Van-der-waals TM5 T 215 5x75 G.H5 D 337 G.H5.09
Polar ICL3 S 223 - G.h4s6 K 317 G.h4s6.11
Hydrophobic H8 K 285 8x48 G.H5 F 354 G.H5.26
Van-der-waals H8 K 285 8x48 G.H5 F 354 G.H5.26
Polar TM3 Y 107 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 Y 107 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 Y 107 3x50 G.H5 C 351 G.H5.23
Hydrophobic ICL3 R 228 - G.H5 F 354 G.H5.26
Hydrophobic TM7 G 283 7x56 G.H5 L 353 G.H5.25
Van-der-waals TM7 G 283 7x56 G.H5 L 353 G.H5.25
Hydrophobic H8 N 284 8x47 G.H5 G 352 G.H5.24
Van-der-waals H8 N 284 8x47 G.H5 G 352 G.H5.24
Polar ICL3 S 219 - G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL3 S 219 - G.h4s6 E 318 G.h4s6.12
Van-der-waals ICL3 S 219 - G.h4s6 E 318 G.h4s6.12
Hydrophobic TM5 M 212 5x72 G.H5 D 337 G.H5.09
Van-der-waals TM5 M 212 5x72 G.H5 D 337 G.H5.09
Hydrophobic TM3 I 111 3x54 G.H5 L 353 G.H5.25
Van-der-waals TM3 I 111 3x54 G.H5 L 353 G.H5.25
Polar ICL3 S 223 - G.h4s6 K 314 G.h4s6.08
Hydrophobic ICL3 S 223 - G.h4s6 K 314 G.h4s6.08
Van-der-waals ICL3 S 223 - G.h4s6 K 314 G.h4s6.08
Hydrophobic TM3 I 111 3x54 G.H5 N 347 G.H5.19
Polar ICL3 G 220 - G.H4 E 308 G.H4.16
Hydrophobic ICL3 G 220 - G.H4 E 308 G.H4.16
Van-der-waals ICL3 G 220 - G.H4 E 308 G.H4.16
Polar H8 K 285 8x48 G.H5 G 352 G.H5.24
Van-der-waals H8 K 285 8x48 G.H5 G 352 G.H5.24
Ionic TM5 H 208 5x68 G.H5 D 341 G.H5.13
Polar TM5 H 208 5x68 G.H5 D 341 G.H5.13
Hydrophobic TM5 H 208 5x68 G.H5 D 341 G.H5.13
Van-der-waals TM5 H 208 5x68 G.H5 D 341 G.H5.13
Polar H8 R 288 8x51 G.H5 L 353 G.H5.25
Polar ICL3 G 220 - G.S6 I 319 G.S6.01
Van-der-waals ICL3 G 220 - G.S6 I 319 G.S6.01
Polar ICL3 T 224 - G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL3 T 224 - G.h4s6 E 318 G.h4s6.12
Van-der-waals ICL3 T 224 - G.h4s6 E 318 G.h4s6.12
Polar ICL3 S 223 - G.h4s6 E 318 G.h4s6.12
Van-der-waals ICL3 S 223 - G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL3 V 216 - G.H5 F 334 G.H5.06
Van-der-waals ICL3 V 216 - G.H5 F 334 G.H5.06
Polar ICL3 S 219 - G.S6 I 319 G.S6.01
Hydrophobic TM2 V 44 2x39 G.H5 C 351 G.H5.23
Van-der-waals TM2 V 44 2x39 G.H5 C 351 G.H5.23
Hydrophobic ICL3 K 225 - G.H5 F 354 G.H5.26
Van-der-waals ICL3 K 225 - G.H5 F 354 G.H5.26
Hydrophobic ICL3 V 216 - G.H5 D 337 G.H5.09
Van-der-waals ICL3 V 216 - G.H5 D 337 G.H5.09
Hydrophobic TM3 F 106 3x49 G.H5 C 351 G.H5.23
Hydrophobic ICL3 D 221 - G.h4s6 E 318 G.h4s6.12
Van-der-waals ICL3 D 221 - G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL3 T 224 - G.h4s6 T 316 G.h4s6.10
Hydrophobic TM3 K 110 3x53 G.H5 C 351 G.H5.23
Van-der-waals TM3 K 110 3x53 G.H5 C 351 G.H5.23
Hydrophobic TM3 I 111 3x54 G.H5 C 351 G.H5.23
Polar TM3 K 110 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 K 110 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 K 110 3x53 G.H5 N 347 G.H5.19