GPR52 - Beta-arrestin-1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

A

ARRESTIN (FAMILY)

Beta

ARRESTIN

Beta-arrestin-1

ARRESTIN SPECIES

Human

ARRESTIN CHAIN

C

ARRESTIN COVERAGE

84

PDB CODE

9IJS

RESOLUTION

3.6 Å

REFERENCE

10.1038/S41422-025-01165-W

PUBLICATION DATE

Sept. 3, 2025

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

0 interactions (Click to see)

LIGANDS

Apo (no ligand) -

PHYSIOLOGICAL LIGANDS

No physiological ligands available



GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic TM1 A 68 1x60 s5s6 G 64 N.s5s6.01
Hydrophobic ICL1 H 73 12x52 S16 A 247 C.S16.01
Hydrophobic H8 V 323 8x49 s15s16 F 244 C.s15s16.03
Hydrophobic TM1 C 67 1x59 s5s6 G 64 N.s5s6.01
Van-der-waals TM1 C 67 1x59 s5s6 G 64 N.s5s6.01
Hydrophobic ICL1 L 70 12x49 S15 I 241 C.S15.14
Polar H8 L 331 8x57 s5s6 G 72 N.s5s6.09
Hydrophobic H8 L 331 8x57 s5s6 G 72 N.s5s6.09
Van-der-waals H8 L 331 8x57 s5s6 G 72 N.s5s6.09
Polar H8 T 334 8x60 s5s6 G 72 N.s5s6.09
Hydrophobic H8 T 334 8x60 s5s6 G 72 N.s5s6.09
Van-der-waals H8 T 334 8x60 s5s6 G 72 N.s5s6.09
Hydrophobic TM1 A 68 1x60 S5 Y 63 N.S5.12
Hydrophobic H8 R 330 8x56 s5s6 G 72 N.s5s6.09
Van-der-waals H8 R 330 8x56 s5s6 G 72 N.s5s6.09
Polar ICL1 H 73 12x52 s15s16 N 245 C.s15s16.04
Hydrophobic ICL1 H 73 12x52 s15s16 N 245 C.s15s16.04
Van-der-waals ICL1 H 73 12x52 s15s16 N 245 C.s15s16.04
Hydrophobic H8 S 322 8x48 s15s16 F 244 C.s15s16.03
Hydrophobic ICL1 L 71 12x50 S16 Y 249 C.S16.03
Hydrophobic ICL1 H 72 12x51 s15s16 N 245 C.s15s16.04
Van-der-waals ICL1 H 72 12x51 s15s16 N 245 C.s15s16.04
Polar H8 T 334 8x60 s5s6 L 71 N.s5s6.08
Van-der-waals ICL1 L 70 12x49 s15s16 N 245 C.s15s16.04
Hydrophobic ICL1 L 71 12x50 S16 A 247 C.S16.01
Van-der-waals ICL1 L 71 12x50 S16 A 247 C.S16.01
Hydrophobic TM6 Y 263 6x33 s15s16 N 245 C.s15s16.04