HCA2 receptor - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

9IQT

RESOLUTION

2.9 Å

REFERENCE

10.1016/J.JMB.2024.168795

PUBLICATION DATE

Oct. 2, 2024

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

17 interactions (Click to see)

LIGANDS

nicotinic acid - Agonist pubchem gtoplig chembl_ligand drugbank drug_central gtoplig pubchem

PHYSIOLOGICAL LIGANDS

β-D-hydroxybutyric acid, butyric acid



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 H 133 - G.S3 L 194 G.S3.01
Van-der-waals ICL2 H 133 - G.S3 L 194 G.S3.01
Hydrophobic ICL3 H 223 - G.H5 K 345 G.H5.17
Ionic TM5 R 218 5x68 G.H5 D 337 G.H5.09
Polar TM5 R 218 5x68 G.H5 D 337 G.H5.09
Polar ICL3 H 223 - G.h4s6 D 315 G.h4s6.09
Hydrophobic ICL3 H 223 - G.h4s6 D 315 G.h4s6.09
Van-der-waals ICL3 H 223 - G.h4s6 D 315 G.h4s6.09
Hydrophobic TM6 I 233 6x37 G.H5 L 353 G.H5.25
Van-der-waals TM6 I 233 6x37 G.H5 L 353 G.H5.25
Polar TM3 R 128 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 R 128 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 R 128 3x53 G.H5 N 347 G.H5.19
Ionic ICL3 R 222 - G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL3 A 224 - G.h4s6 D 315 G.h4s6.09
Ionic TM3 R 128 3x53 G.H5 D 350 G.H5.22
Hydrophobic TM3 R 128 3x53 G.H5 D 350 G.H5.22
Van-der-waals TM3 R 128 3x53 G.H5 D 350 G.H5.22
Hydrophobic TM3 V 129 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 V 129 3x54 G.H5 L 348 G.H5.20
Ionic TM2 K 60 2x37 G.H5 D 350 G.H5.22
Polar TM2 K 60 2x37 G.H5 D 350 G.H5.22
Hydrophobic TM2 K 60 2x37 G.H5 D 350 G.H5.22
Van-der-waals TM2 K 60 2x37 G.H5 D 350 G.H5.22
Hydrophobic TM5 L 215 5x65 G.H5 I 344 G.H5.16
Hydrophobic ICL2 P 132 - G.H5 I 343 G.H5.15
Van-der-waals ICL2 P 132 - G.H5 I 343 G.H5.15
Aromatic ICL2 H 133 - G.H5 F 336 G.H5.08
Hydrophobic ICL2 H 133 - G.H5 F 336 G.H5.08
Van-der-waals ICL2 H 133 - G.H5 F 336 G.H5.08
Hydrophobic TM5 L 215 5x65 G.H5 L 348 G.H5.20
Hydrophobic C-term P 299 - G.H5 G 352 G.H5.24
Polar C-term S 298 - G.H5 G 352 G.H5.24
Hydrophobic C-term S 298 - G.H5 G 352 G.H5.24
Van-der-waals C-term S 298 - G.H5 G 352 G.H5.24
Hydrophobic TM3 R 125 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM5 R 218 5x68 G.H5 T 340 G.H5.12
Van-der-waals TM5 R 218 5x68 G.H5 T 340 G.H5.12
Hydrophobic ICL3 M 220 - G.H5 I 344 G.H5.16
Van-der-waals ICL3 M 220 - G.H5 I 344 G.H5.16
Hydrophobic ICL2 K 138 - G.hns1 A 31 G.hns1.02
Hydrophobic TM3 R 128 3x53 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 128 3x53 G.H5 C 351 G.H5.23
Polar ICL2 N 137 - G.H5 N 347 G.H5.19
Polar ICL2 H 133 - G.H5 T 340 G.H5.12
Hydrophobic ICL2 H 133 - G.H5 T 340 G.H5.12
Van-der-waals ICL2 H 133 - G.H5 T 340 G.H5.12
Hydrophobic TM6 I 226 6x30 G.H5 L 348 G.H5.20
Hydrophobic ICL2 N 137 - G.H5 N 347 G.H5.19
Ionic TM5 R 218 5x68 G.H5 D 341 G.H5.13
Hydrophobic TM3 V 129 3x54 G.H5 I 344 G.H5.16
Van-der-waals TM3 V 129 3x54 G.H5 I 344 G.H5.16
Polar TM5 R 218 5x68 G.H5 D 341 G.H5.13
Van-der-waals TM5 R 218 5x68 G.H5 D 341 G.H5.13
Hydrophobic ICL3 M 220 - G.H5 D 341 G.H5.13
Hydrophobic TM3 R 125 3x50 G.H5 L 353 G.H5.25
Van-der-waals TM3 R 125 3x50 G.H5 L 353 G.H5.25
Hydrophobic ICL2 H 133 - G.H5 I 343 G.H5.15
Van-der-waals ICL2 H 133 - G.H5 I 343 G.H5.15
Hydrophobic ICL2 P 132 - G.H5 T 340 G.H5.12
Van-der-waals ICL2 P 132 - G.H5 T 340 G.H5.12
Hydrophobic TM5 R 218 5x68 G.H5 I 344 G.H5.16
Van-der-waals TM5 R 218 5x68 G.H5 I 344 G.H5.16
Hydrophobic TM6 A 229 6x33 G.H5 L 353 G.H5.25
Ionic ICL3 H 223 - G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL3 H 223 - G.h4s6 E 318 G.h4s6.12
Van-der-waals ICL3 H 223 - G.h4s6 E 318 G.h4s6.12
Polar ICL2 K 138 - G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 K 138 - G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 K 138 - G.hns1 R 32 G.hns1.03
Hydrophobic TM2 R 63 2x40 G.H5 G 352 G.H5.24
Hydrophobic C-term P 299 - G.H5 L 353 G.H5.25
Hydrophobic TM6 K 225 6x29 G.H5 K 349 G.H5.21
Van-der-waals TM6 K 225 6x29 G.H5 K 349 G.H5.21
Hydrophobic ICL2 P 132 - G.H5 I 344 G.H5.16
Van-der-waals ICL2 P 132 - G.H5 I 344 G.H5.16
Van-der-waals ICL2 P 132 - G.H5 N 347 G.H5.19
Polar TM2 S 62 2x39 G.H5 C 351 G.H5.23
Hydrophobic TM2 S 62 2x39 G.H5 C 351 G.H5.23
Van-der-waals TM2 S 62 2x39 G.H5 C 351 G.H5.23
Hydrophobic TM6 I 226 6x30 G.H5 K 345 G.H5.17
Hydrophobic ICL3 M 220 - G.H5 K 345 G.H5.17
Van-der-waals ICL3 M 220 - G.H5 K 345 G.H5.17