GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

ARRESTIN (FAMILY)

Gs

ARRESTIN

s

ARRESTIN SPECIES

Bovine

ARRESTIN CHAIN

A

ARRESTIN COVERAGE

58

PDB CODE

RESOLUTION

3.2 Å

REFERENCE

PUBLICATION DATE

Dec. 31, 2025

3D VIEW

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LIGAND INTERACTIONS

LIGANDS

CHEMBL1615159 - Agonist chembl_ligand pubchem ,

ATAZANAVIR - Ago-PAM chembl_ligand pubchem drugbank

PHYSIOLOGICAL LIGANDS

(-)-noradrenaline, noradrenaline, (-)-adrenaline, Zn2+



GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type
GPCR
Segment

AA

Number
Generic
number
Arrestin
segment

AA

Number
Generic
number
Ionic H8 R 333 8x51 S11 E 185 C.S11.02
Hydrophobic TM7 F 321 7x48 s11s12 K 195 C.s11s12.06
Aromatic TM6 R 273 6x35 s11s12 F 190 C.s11s12.01
Hydrophobic TM6 R 273 6x35 s11s12 F 190 C.s11s12.01
Van-der-waals TM6 R 273 6x35 s11s12 F 190 C.s11s12.01
Polar H8 Q 337 8x55 S11 E 185 C.S11.02
Hydrophobic H8 Q 337 8x55 S11 E 185 C.S11.02
Van-der-waals H8 Q 337 8x55 S11 E 185 C.S11.02
Polar H8 R 333 8x51 S11 T 187 C.S11.04
Hydrophobic ICL3 H 269 - s11s12 F 190 C.s11s12.01
Hydrophobic ICL4 R 328 - S11 R 188 C.S11.05
Van-der-waals ICL4 R 328 - S11 R 188 C.S11.05