PTH1 receptor - Beta-arrestin-1

GPCR CLASS (FAMILY)

Class B1 (Secretin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

ARRESTIN (FAMILY)

Beta

ARRESTIN

Beta-arrestin-1

ARRESTIN SPECIES

Human

ARRESTIN CHAIN

B

ARRESTIN COVERAGE

83

PDB CODE

9LXP

RESOLUTION

3.2 Å

REFERENCE

PUBLICATION DATE

March 4, 2026

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

112 interactions (Click to see)

LIGANDS

Long-acting parathyroid hormone analog - Agonist pubchem

PHYSIOLOGICAL LIGANDS

PTHrP-(1-36) (Human), PTHrP (Human), TIP39 (Human), PTH (Human), PTH (Mouse), PTH (Rat)



GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic ICL2 F 314 - s17s18 G 286 C.s17s18.12
Hydrophobic TM3 I 310 3x58 S5 Y 63 N.S5.12
Polar ICL3 C 397 - S6 C 81 N.S6.07
Hydrophobic ICL3 C 397 - S6 C 81 N.S6.07
Van-der-waals ICL3 C 397 - S6 C 81 N.S6.07
Hydrophobic ICL3 C 397 - S6 D 78 N.S6.04
Hydrophobic ICL3 A 394 - S6 F 80 N.S6.06
Van-der-waals ICL3 A 394 - S6 F 80 N.S6.06
Hydrophobic TM5 K 388 5x64 S6 K 77 N.S6.03
Van-der-waals TM5 K 388 5x64 S6 K 77 N.S6.03
Hydrophobic TM3 L 309 3x57 s5s6 L 68 N.s5s6.05
Van-der-waals TM3 L 309 3x57 s5s6 L 68 N.s5s6.05
Hydrophobic TM5 T 387 5x63 s15s16 F 244 C.s15s16.03
Hydrophobic ICL2 A 313 - s17s18 G 286 C.s17s18.12
Hydrophobic TM6 V 412 6x44 s5s6 V 70 N.s5s6.07
Hydrophobic C-term V 500 - s1s2 C 14 N.s1s2.02
Van-der-waals C-term V 500 - s1s2 C 14 N.s1s2.02
Hydrophobic ICL3 G 395 - S6 A 82 N.S6.08
Hydrophobic ICL3 C 397 - S6 F 80 N.S6.06
Van-der-waals ICL3 C 397 - S6 F 80 N.S6.06
Polar TM2 R 219 2x46 s5s6 D 67 N.s5s6.04
Hydrophobic TM2 R 219 2x46 s5s6 D 67 N.s5s6.04
Van-der-waals TM2 R 219 2x46 s5s6 D 67 N.s5s6.04
Hydrophobic TM5 K 388 5x64 s15s16 F 244 C.s15s16.03
Van-der-waals TM5 K 388 5x64 s15s16 F 244 C.s15s16.03
Hydrophobic TM6 S 409 6x41 s5s6 L 73 N.s5s6.10
Hydrophobic C-term N 507 - ns1 R 7 N.ns1.15
Hydrophobic TM3 L 306 3x54 S6 F 75 N.S6.01
Van-der-waals ICL3 N 393 - S6 F 80 N.S6.06
Polar TM3 F 311 3x59 S16 Y 249 C.S16.03
Van-der-waals TM3 F 311 3x59 S16 Y 249 C.S16.03
Hydrophobic ICL3 R 396 - S6 N 83 N.S6.09
Polar ICL2 A 313 - s17s18 R 285 C.s17s18.11
Hydrophobic ICL2 A 313 - s17s18 R 285 C.s17s18.11
Van-der-waals ICL2 A 313 - s17s18 R 285 C.s17s18.11
Hydrophobic ICL2 A 313 - S16 Y 249 C.S16.03
Van-der-waals ICL2 A 313 - S16 Y 249 C.S16.03
Hydrophobic TM6 K 408 6x40 s5s6 L 71 N.s5s6.08
Polar ICL3 N 393 - S6 L 79 N.S6.05
Hydrophobic ICL3 N 393 - S6 L 79 N.S6.05
Van-der-waals ICL3 N 393 - S6 L 79 N.S6.05
Polar ICL3 R 396 - S6 C 81 N.S6.07
Hydrophobic ICL3 R 396 - S6 C 81 N.S6.07
Van-der-waals ICL3 R 396 - S6 C 81 N.S6.07
Hydrophobic TM5 V 384 5x60 s15s16 F 244 C.s15s16.03
Van-der-waals TM5 V 384 5x60 s15s16 F 244 C.s15s16.03
Hydrophobic TM3 M 312 3x60 S16 Y 249 C.S16.03
Hydrophobic TM3 L 306 3x54 s5s6 L 68 N.s5s6.05
Hydrophobic TM3 L 309 3x57 s5s6 R 65 N.s5s6.02
Van-der-waals TM3 L 309 3x57 s5s6 R 65 N.s5s6.02
Hydrophobic TM3 I 310 3x58 S6 F 75 N.S6.01
Hydrophobic ICL3 G 395 - S6 C 81 N.S6.07
Van-der-waals ICL3 G 395 - S6 C 81 N.S6.07
Hydrophobic TM6 L 413 6x45 s5s6 L 73 N.s5s6.10
Hydrophobic TM3 F 311 3x59 s15s16 N 245 C.s15s16.04
Hydrophobic TM7 C 462 7x60 s5s6 L 71 N.s5s6.08
Hydrophobic C-term H 502 - S1 K 11 N.S1.04
Hydrophobic TM7 Y 459 7x57 s5s6 V 70 N.s5s6.07
Van-der-waals TM7 Y 459 7x57 s5s6 V 70 N.s5s6.07
Polar C-term V 505 - ns1 R 7 N.ns1.15
Hydrophobic C-term V 505 - ns1 R 7 N.ns1.15
Polar C-term N 507 - H1 K 107 N.H1.09
Hydrophobic C-term N 507 - H1 K 107 N.H1.09
Van-der-waals C-term N 507 - H1 K 107 N.H1.09
Polar TM3 Y 305 3x53 s5s6 R 65 N.s5s6.02
Hydrophobic ICL2 F 314 - s17s18 R 285 C.s17s18.11
Van-der-waals ICL2 F 314 - s17s18 R 285 C.s17s18.11
Hydrophobic ICL2 F 314 - S16 Y 249 C.S16.03
Van-der-waals ICL2 F 314 - S16 Y 249 C.S16.03
Hydrophobic TM6 K 408 6x40 s5s6 G 72 N.s5s6.09
Van-der-waals TM6 K 408 6x40 s5s6 G 72 N.s5s6.09
Hydrophobic TM6 V 412 6x44 s5s6 L 73 N.s5s6.10
Van-der-waals TM6 V 412 6x44 s5s6 L 73 N.s5s6.10
Hydrophobic ICL2 F 314 - S16 C 251 C.S16.05
Van-der-waals ICL2 F 314 - S16 C 251 C.S16.05
Hydrophobic TM2 R 219 2x46 s5s6 L 68 N.s5s6.05
Hydrophobic TM7 I 458 7x56 s5s6 L 71 N.s5s6.08
Hydrophobic C-term N 507 - S1 V 8 N.S1.01
Hydrophobic TM5 L 385 5x61 s5s6 L 73 N.s5s6.10