GPCR CLASS (FAMILY)

Class B1 (Secretin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

ARRESTIN (FAMILY)

Beta

ARRESTIN

ARRESTIN SPECIES

Human

ARRESTIN CHAIN

B

ARRESTIN COVERAGE

80

PDB CODE

RESOLUTION

3.4 Å

REFERENCE

PUBLICATION DATE

March 4, 2026

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

LIGANDS

Long-acting parathyroid hormone analog - Agonist pubchem

PHYSIOLOGICAL LIGANDS

PTHrP-(1-36) (Human), PTHrP (Human), TIP39 (Human), PTH (Human), PTH (Mouse), PTH (Rat)



GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type
GPCR
Segment

AA

Number
Generic
number
Arrestin
segment

AA

Number
Generic
number
Polar TM5 K 388 5x64 S6 K 77 N.S6.03
Hydrophobic TM3 L 309 3x57 s5s6 L 68 N.s5s6.05
Van-der-waals TM3 L 309 3x57 s5s6 L 68 N.s5s6.05
Hydrophobic TM2 C 217 2x44 s8s9 E 134 N.s8s9.05
Hydrophobic TM6 V 412 6x44 s5s6 V 70 N.s5s6.07
Polar C-term L 525 - ns1 T 6 N.ns1.14
Hydrophobic C-term L 525 - ns1 T 6 N.ns1.14
Van-der-waals C-term L 525 - ns1 T 6 N.ns1.14
Polar C-term C 518 - S1 A 12 N.S1.05
Hydrophobic C-term C 518 - S1 A 12 N.S1.05
Van-der-waals C-term C 518 - S1 A 12 N.S1.05
Ionic TM2 R 219 2x46 s5s6 D 67 N.s5s6.04
Polar TM2 R 219 2x46 s5s6 D 67 N.s5s6.04
Hydrophobic TM2 R 219 2x46 s5s6 D 67 N.s5s6.04
Van-der-waals TM2 R 219 2x46 s5s6 D 67 N.s5s6.04
Hydrophobic TM5 K 388 5x64 s15s16 F 244 C.s15s16.03
Van-der-waals TM5 K 388 5x64 s15s16 F 244 C.s15s16.03
Hydrophobic TM6 K 408 6x40 s5s6 L 71 N.s5s6.08
Hydrophobic C-term L 525 - H1 L 104 N.H1.06
Hydrophobic TM5 V 384 5x60 s15s16 F 244 C.s15s16.03
Hydrophobic C-term L 525 - S1 V 8 N.S1.01
Polar C-term A 521 - S1 K 10 N.S1.03
Hydrophobic C-term A 521 - S1 K 10 N.S1.03
Van-der-waals C-term A 521 - S1 K 10 N.S1.03
Hydrophobic TM5 L 385 5x61 s5s6 L 73 N.s5s6.10
Van-der-waals TM5 L 385 5x61 s5s6 L 73 N.s5s6.10
Hydrophobic TM5 L 385 5x61 s15s16 F 244 C.s15s16.03
Polar C-term A 526 - H1 R 103 N.H1.05
Hydrophobic TM6 V 412 6x44 s5s6 L 71 N.s5s6.08