PTH1 receptor - Beta-arrestin-1

GPCR CLASS (FAMILY)

Class B1 (Secretin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

ARRESTIN (FAMILY)

Beta

ARRESTIN

Beta-arrestin-1

ARRESTIN SPECIES

Bovine

ARRESTIN CHAIN

A

ARRESTIN COVERAGE

83

PDB CODE

9LZ1

RESOLUTION

3.2 Å

REFERENCE

PUBLICATION DATE

March 11, 2026

3D VIEW

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LIGAND INTERACTIONS

86 interactions (Click to see)

LIGANDS

Long-acting parathyroid hormone analog - Agonist pubchem

PHYSIOLOGICAL LIGANDS

PTHrP-(1-36) (Human), PTHrP (Human), TIP39 (Human), PTH (Human), PTH (Mouse), PTH (Rat)



GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic TM6 S 409 6x41 s5s6 V 70 N.s5s6.07
Van-der-waals TM6 S 409 6x41 s5s6 V 70 N.s5s6.07
Hydrophobic ICL2 M 312 - s15s16 F 244 C.s15s16.03
Van-der-waals ICL2 M 312 - s15s16 F 244 C.s15s16.03
Hydrophobic ICL2 A 313 - s5s6 T 74 N.s5s6.11
Hydrophobic TM3 I 310 3x58 s5s6 L 73 N.s5s6.10
Van-der-waals TM3 I 310 3x58 s5s6 L 73 N.s5s6.10
Hydrophobic H8 N 463 8x47 s5s6 L 68 N.s5s6.05
Van-der-waals H8 N 463 8x47 s5s6 L 68 N.s5s6.05
Hydrophobic C-term V 505 - S1 V 8 N.S1.01
Van-der-waals C-term V 505 - S1 V 8 N.S1.01
Hydrophobic ICL2 A 313 - S5 Y 63 N.S5.12
Polar C-term N 507 - ns1 T 6 N.ns1.14
Hydrophobic C-term N 507 - ns1 T 6 N.ns1.14
Van-der-waals C-term N 507 - ns1 T 6 N.ns1.14
Hydrophobic TM5 K 388 5x64 S6 F 75 N.S6.01
Van-der-waals TM5 K 388 5x64 S6 F 75 N.S6.01
Van-der-waals H8 G 464 8x48 s8s9 E 134 N.s8s9.05
Hydrophobic ICL2 F 314 - S16 Y 249 C.S16.03
Van-der-waals ICL2 F 314 - S16 Y 249 C.S16.03
Hydrophobic ICL1 L 215 - s8s9 E 134 N.s8s9.05
Polar C-term V 508 - ns1 T 6 N.ns1.14
Hydrophobic TM3 F 311 3x59 s15s16 F 244 C.s15s16.03
Van-der-waals TM3 F 311 3x59 s15s16 F 244 C.s15s16.03
Van-der-waals C-term H 502 - S1 K 11 N.S1.04
Polar ICL1 R 214 - s17s18 R 285 C.s17s18.11
Hydrophobic TM5 L 385 5x61 s5s6 L 73 N.s5s6.10
Polar C-term T 506 - S1 V 8 N.S1.01
Van-der-waals TM5 K 388 5x64 s5s6 G 72 N.s5s6.09
Polar C-term N 507 - ns1 R 7 N.ns1.15
Hydrophobic C-term N 507 - ns1 R 7 N.ns1.15
Van-der-waals C-term N 507 - ns1 R 7 N.ns1.15
Hydrophobic H8 A 468 8x52 s8s9 E 134 N.s8s9.05
Van-der-waals H8 A 468 8x52 s8s9 E 134 N.s8s9.05
Hydrophobic ICL2 A 313 - s15s16 F 244 C.s15s16.03
Van-der-waals ICL2 A 313 - s15s16 F 244 C.s15s16.03
Hydrophobic TM2 H 223 2x50 s5s6 L 68 N.s5s6.05
Hydrophobic TM3 L 309 3x57 s5s6 R 65 N.s5s6.02
Van-der-waals TM3 L 309 3x57 s5s6 R 65 N.s5s6.02
Polar H8 E 465 8x49 s8s9 E 134 N.s8s9.05
Hydrophobic H8 E 465 8x49 s8s9 E 134 N.s8s9.05
Van-der-waals H8 E 465 8x49 s8s9 E 134 N.s8s9.05
Hydrophobic ICL2 F 315 - S16 A 247 C.S16.01
Van-der-waals ICL2 F 314 - s15s16 N 245 C.s15s16.04
Ionic TM2 R 219 2x46 s5s6 D 67 N.s5s6.04
Ionic TM4 E 317 4x39 s5s6 R 65 N.s5s6.02
Polar TM4 E 317 4x39 s5s6 R 65 N.s5s6.02
Van-der-waals TM4 E 317 4x39 s5s6 R 65 N.s5s6.02
Hydrophobic TM2 R 219 2x46 s5s6 L 68 N.s5s6.05
Van-der-waals TM2 R 219 2x46 s5s6 L 68 N.s5s6.05
Polar ICL3 N 393 - s9s10 K 157 N.s9s10.09
Van-der-waals ICL3 N 393 - s9s10 K 157 N.s9s10.09
Hydrophobic C-term V 505 - ns1 R 7 N.ns1.15
Van-der-waals C-term V 505 - ns1 R 7 N.ns1.15
Hydrophobic TM5 L 385 5x61 s5s6 V 70 N.s5s6.07
Hydrophobic ICL2 F 314 - S15 I 241 C.S15.14
Hydrophobic C-term V 505 - S1 F 9 N.S1.02
Hydrophobic C-term V 508 - S1 V 8 N.S1.01
Van-der-waals C-term V 508 - S1 V 8 N.S1.01
Polar C-term V 508 - H1 K 107 N.H1.09
Hydrophobic C-term V 508 - H1 K 107 N.H1.09
Van-der-waals C-term V 508 - H1 K 107 N.H1.09
Polar ICL2 F 314 - S16 A 247 C.S16.01
Hydrophobic ICL2 F 314 - S16 A 247 C.S16.01
Van-der-waals ICL2 F 314 - S16 A 247 C.S16.01
Polar ICL2 A 313 - s15s16 N 245 C.s15s16.04
Ionic H8 E 465 8x49 s17s18 R 285 C.s17s18.11
Polar H8 E 469 8x53 s8s9 E 134 N.s8s9.05
Hydrophobic H8 E 469 8x53 s8s9 E 134 N.s8s9.05
Van-der-waals H8 E 469 8x53 s8s9 E 134 N.s8s9.05
Hydrophobic H8 E 465 8x49 s5s6 L 68 N.s5s6.05
Van-der-waals H8 E 465 8x49 s5s6 L 68 N.s5s6.05
Hydrophobic TM3 L 306 3x54 s5s6 D 67 N.s5s6.04
Ionic H8 K 472 8x56 s8s9 E 134 N.s8s9.05
Polar H8 K 472 8x56 s8s9 E 134 N.s8s9.05
Van-der-waals H8 K 472 8x56 s8s9 E 134 N.s8s9.05