chemerin receptor 2 - Beta-arrestin-1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

ARRESTIN (FAMILY)

Beta

ARRESTIN

Beta-arrestin-1

ARRESTIN SPECIES

Human

ARRESTIN CHAIN

A

ARRESTIN COVERAGE

82

PDB CODE

9UYN

RESOLUTION

2.9 Å

REFERENCE

10.1126/SCIENCE.ADT8794

PUBLICATION DATE

Nov. 19, 2025

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

17 interactions (Click to see)

LIGANDS

Palmitoleic Acid - Allosteric agonist pubchem drugbank

PHYSIOLOGICAL LIGANDS

chemerin (Human)



GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Polar ICL3 I 238 - S6 K 77 N.S6.03
Hydrophobic ICL3 I 238 - S6 K 77 N.S6.03
Van-der-waals ICL3 I 238 - S6 K 77 N.S6.03
Ionic ICL3 K 235 - s17s18 E 313 C.s17s18.39
Hydrophobic TM3 L 139 3x54 s15s16 F 244 C.s15s16.03
Van-der-waals TM3 L 139 3x54 s15s16 F 244 C.s15s16.03
Polar ICL2 H 146 - s17s18 G 286 C.s17s18.12
Hydrophobic ICL2 H 146 - s17s18 G 286 C.s17s18.12
Van-der-waals ICL2 H 146 - s17s18 G 286 C.s17s18.12
Hydrophobic TM1 W 67 1x61 s5s6 L 68 N.s5s6.05
Hydrophobic TM3 H 138 3x53 S6 F 75 N.S6.01
Hydrophobic ICL1 T 70 - s5s6 R 65 N.s5s6.02
Van-der-waals ICL1 T 70 - s5s6 R 65 N.s5s6.02
Hydrophobic ICL2 P 142 - S16 A 247 C.S16.01
Van-der-waals ICL2 P 142 - S16 A 247 C.S16.01
Polar TM3 H 138 3x53 S5 Y 63 N.S5.12
Aromatic TM3 H 138 3x53 S5 Y 63 N.S5.12
Hydrophobic TM3 H 138 3x53 S5 Y 63 N.S5.12
Van-der-waals TM3 H 138 3x53 S5 Y 63 N.S5.12
Polar ICL3 K 234 - s15s16 F 244 C.s15s16.03
Hydrophobic TM7 Y 304 7x53 s5s6 L 71 N.s5s6.08
Polar ICL1 T 72 - s5s6 E 66 N.s5s6.03
Hydrophobic ICL1 T 72 - s5s6 E 66 N.s5s6.03
Van-der-waals ICL1 T 72 - s5s6 E 66 N.s5s6.03
Hydrophobic C-term L 1365 - H1 K 107 N.H1.09
Van-der-waals C-term L 1365 - H1 K 107 N.H1.09
Polar TM6 T 247 6x36 s5s6 L 71 N.s5s6.08
Hydrophobic TM6 T 247 6x36 s5s6 L 71 N.s5s6.08
Hydrophobic C-term L 1365 - H1 R 103 N.H1.05
Van-der-waals C-term L 1365 - H1 R 103 N.H1.05
Hydrophobic ICL3 I 238 - s15s16 L 243 C.s15s16.02
Hydrophobic ICL2 H 146 - S9 I 140 N.S9.01
Ionic ICL3 K 234 - s17s18 E 313 C.s17s18.39
Polar ICL3 K 234 - s17s18 E 313 C.s17s18.39
Hydrophobic ICL2 R 147 - s17s18 K 284 C.s17s18.10
Hydrophobic ICL2 P 142 - S15 I 241 C.S15.14
Van-der-waals TM6 H 244 6x33 s5s6 L 71 N.s5s6.08
Polar ICL1 K 68 - s8s9 T 136 N.s8s9.07
Polar ICL2 C 143 - S16 Q 248 C.S16.02
Hydrophobic ICL2 C 143 - S16 Q 248 C.S16.02
Van-der-waals ICL2 C 143 - S16 Q 248 C.S16.02
Hydrophobic H8 S 308 8x47 s5s6 L 71 N.s5s6.08
Van-der-waals H8 S 308 8x47 s5s6 L 71 N.s5s6.08
Hydrophobic ICL3 I 238 - s15s16 F 244 C.s15s16.03
Van-der-waals ICL3 I 238 - s15s16 F 244 C.s15s16.03
Aromatic TM6 H 244 6x33 S6 F 75 N.S6.01
Hydrophobic TM6 H 244 6x33 S6 F 75 N.S6.01
Van-der-waals TM6 H 244 6x33 S6 F 75 N.S6.01
Polar C-term A 1366 - H1 R 103 N.H1.05
Hydrophobic ICL2 R 147 - s17s18 R 285 C.s17s18.11
Van-der-waals ICL2 R 147 - s17s18 R 285 C.s17s18.11
Hydrophobic ICL2 H 146 - S5 Y 63 N.S5.12
Polar ICL3 S 241 - S6 K 77 N.S6.03
Polar ICL1 T 70 - s5s6 E 66 N.s5s6.03
Hydrophobic ICL1 T 70 - s5s6 E 66 N.s5s6.03
Van-der-waals ICL1 T 70 - s5s6 E 66 N.s5s6.03
Hydrophobic ICL2 H 146 - S8 L 129 N.S8.03
Van-der-waals ICL2 H 146 - S8 L 129 N.S8.03
Polar ICL2 H 146 - s17s18 R 285 C.s17s18.11
Hydrophobic ICL2 H 146 - s17s18 R 285 C.s17s18.11
Van-der-waals ICL2 H 146 - s17s18 R 285 C.s17s18.11
Hydrophobic C-term L 1365 - S1 V 8 N.S1.01
Ionic ICL2 R 149 - s5s6 E 66 N.s5s6.03
Hydrophobic TM3 I 140 3x55 s15s16 N 245 C.s15s16.04
Van-der-waals TM3 I 140 3x55 s15s16 N 245 C.s15s16.04
Polar H8 S 308 8x47 s5s6 V 70 N.s5s6.07
Van-der-waals H8 S 308 8x47 s5s6 V 70 N.s5s6.07
Hydrophobic ICL3 L 239 - s15s16 F 244 C.s15s16.03
Hydrophobic TM6 H 244 6x33 s5s6 L 73 N.s5s6.10
Hydrophobic C-term K 1367 - H1 R 103 N.H1.05
Van-der-waals C-term K 1367 - H1 R 103 N.H1.05
Hydrophobic TM6 H 244 6x33 s5s6 G 72 N.s5s6.09
Polar C-term L 1365 - ns1 T 6 N.ns1.14
Hydrophobic C-term L 1365 - ns1 T 6 N.ns1.14
Van-der-waals C-term L 1365 - ns1 T 6 N.ns1.14
Hydrophobic TM2 T 73 2x40 s5s6 L 73 N.s5s6.10
Hydrophobic ICL2 H 146 - S15 I 241 C.S15.14
Hydrophobic ICL1 T 72 - s5s6 L 73 N.s5s6.10
Hydrophobic TM7 I 307 7x56 s5s6 L 71 N.s5s6.08
Van-der-waals TM7 I 307 7x56 s5s6 L 71 N.s5s6.08
Hydrophobic ICL3 V 233 - s15s16 F 244 C.s15s16.03
Van-der-waals ICL3 V 233 - s15s16 F 244 C.s15s16.03
Hydrophobic C-term L 1365 - H1 L 100 N.H1.02
Polar H8 K 310 8x49 s5s6 D 69 N.s5s6.06
Hydrophobic H8 K 310 8x49 s5s6 D 69 N.s5s6.06
Van-der-waals H8 K 310 8x49 s5s6 D 69 N.s5s6.06
Hydrophobic ICL3 R 243 - s15s16 F 244 C.s15s16.03
Hydrophobic C-term L 1365 - H1 L 104 N.H1.06
Polar ICL2 C 143 - S16 C 249 C.S16.03
Hydrophobic ICL2 C 143 - S16 C 249 C.S16.03
Van-der-waals ICL2 C 143 - S16 C 249 C.S16.03
Hydrophobic TM1 W 67 1x61 s5s6 V 70 N.s5s6.07