κ receptor - Beta-arrestin-1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

A

ARRESTIN (FAMILY)

Beta

ARRESTIN

Beta-arrestin-1

ARRESTIN SPECIES

Human

ARRESTIN CHAIN

C

ARRESTIN COVERAGE

84

PDB CODE

9ZZO

RESOLUTION

2.6 Å

REFERENCE

10.1038/S41467-026-73968-3

PUBLICATION DATE

June 17, 2026

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

35 interactions (Click to see)

LIGANDS

CHEMBL5431513 - Agonist chembl_ligand pubchem

PHYSIOLOGICAL LIGANDS

[Met]enkephalin (Human), β-neoendorphin (Human), dynorphin A (Human), dynorphin A-(1-8) (Human), dynorphin A-(1-13) (Human), big dynorphin (Human), β-endorphin (Mouse), β-endorphin (Rat), dynorphin B (Human), β-endorphin (Human), α-neoendorphin (Human), [Leu]enkephalin (Human)



GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic ICL2 L 167 34x54 S9 I 140 N.S9.03
Polar TM6 N 268 6x29 s5s6 G 72 N.s5s6.11
Hydrophobic TM6 N 268 6x29 s5s6 G 72 N.s5s6.11
Van-der-waals TM6 N 268 6x29 s5s6 G 72 N.s5s6.11
Polar C-term A 382 - S1 K 10 N.S1.05
Hydrophobic C-term A 382 - S1 K 10 N.S1.05
Van-der-waals C-term A 382 - S1 K 10 N.S1.05
Hydrophobic TM5 L 253 5x65 S6 L 73 N.S6.01
Hydrophobic C-term C 379 - s1s2 P 14 N.s1s2.04
Hydrophobic TM2 T 94 2x39 s5s6 L 68 N.s5s6.07
Van-der-waals TM2 T 94 2x39 s5s6 L 68 N.s5s6.07
Hydrophobic TM6 I 272 6x33 s5s6 L 71 N.s5s6.10
Van-der-waals TM6 I 272 6x33 s5s6 L 71 N.s5s6.10
Hydrophobic TM6 I 272 6x33 S6 L 73 N.S6.01
Van-der-waals TM6 I 272 6x33 S6 L 73 N.S6.01
Hydrophobic ICL3 V 256 - s15s16 F 244 C.s15s16.05
Hydrophobic TM3 V 160 3x54 S6 F 75 N.S6.03
Van-der-waals TM3 V 160 3x54 S6 F 75 N.S6.03
Hydrophobic TM7 L 333 7x56 s5s6 L 71 N.s5s6.10
Hydrophobic TM6 R 271 6x32 s5s6 G 72 N.s5s6.11
Hydrophobic ICL2 V 164 34x51 S16 Y 249 C.S16.05
Van-der-waals ICL2 V 164 34x51 S16 Y 249 C.S16.05
Hydrophobic ICL2 D 168 34x55 s17s18 R 285 C.s17s18.13
Van-der-waals ICL2 D 168 34x55 s17s18 R 285 C.s17s18.13
Hydrophobic C-term L 386 - H1 L 100 N.H1.04
Hydrophobic TM2 T 94 2x39 s5s6 D 69 N.s5s6.08
Van-der-waals TM2 T 94 2x39 s5s6 D 69 N.s5s6.08
Polar TM6 N 268 6x29 S6 L 73 N.S6.01
Hydrophobic TM6 N 268 6x29 S6 L 73 N.S6.01
Hydrophobic C-term L 386 - ns1 S 0 N.ns1.10
Hydrophobic ICL2 R 170 34x57 s5s6 L 68 N.s5s6.07
Van-der-waals ICL2 R 170 34x57 s5s6 L 68 N.s5s6.07
Hydrophobic ICL2 P 163 34x50 s5s6 Y 63 N.s5s6.02
Van-der-waals ICL2 P 163 34x50 s5s6 Y 63 N.s5s6.02
Polar ICL2 H 162 - S16 N 245 C.S16.01
Hydrophobic ICL2 H 162 - S16 N 245 C.S16.01
Van-der-waals ICL2 H 162 - S16 N 245 C.S16.01
Hydrophobic C-term L 386 - S1 V 8 N.S1.03
Van-der-waals C-term L 386 - S1 V 8 N.S1.03
Hydrophobic ICL2 V 164 34x51 s15s16 I 241 C.s15s16.02
Van-der-waals ICL2 V 164 34x51 s15s16 I 241 C.s15s16.02
Hydrophobic C-term S 378 - s1s2 P 14 N.s1s2.04
Polar ICL2 K 165 34x52 S16 Y 249 C.S16.05
Hydrophobic ICL2 K 165 34x52 S16 Y 249 C.S16.05
Van-der-waals ICL2 K 165 34x52 S16 Y 249 C.S16.05
Hydrophobic TM6 R 271 6x32 s5s6 L 71 N.s5s6.10
Van-der-waals TM6 R 271 6x32 s5s6 L 71 N.s5s6.10
Hydrophobic ICL2 P 163 34x50 s15s16 L 243 C.s15s16.04
Polar C-term C 379 - s1s2 K 11 N.s1s2.01
Hydrophobic C-term C 379 - s1s2 K 11 N.s1s2.01
Van-der-waals C-term C 379 - s1s2 K 11 N.s1s2.01
Hydrophobic C-term L 386 - H1 R 103 N.H1.07
Van-der-waals C-term L 386 - H1 R 103 N.H1.07
Hydrophobic C-term K 388 - S1 T 6 N.S1.01
Polar C-term L 386 - S1 T 6 N.S1.01
Hydrophobic C-term L 386 - S1 T 6 N.S1.01
Van-der-waals C-term L 386 - S1 T 6 N.S1.01
Hydrophobic C-term L 386 - H1 L 104 N.H1.08
Hydrophobic C-term L 386 - h1s7 K 107 N.h1s7.01
Polar C-term A 387 - H1 R 103 N.H1.07
Van-der-waals C-term A 387 - H1 R 103 N.H1.07
Hydrophobic C-term E 335 - s5s6 V 70 N.s5s6.09