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RECEPTOR
| STRUCTURE
| SIGNAL PROTEIN
| AUXILIARY PROTEIN
| STRUCTURE LIGAND
| PHYSIOLOGICAL LIGAND
| SODIUM ION SITE
| REFERENCE
| ANNOTATED
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UniProt
| IUPHAR | Receptor family | Cl. | Species | Method | PDB
| Resolution | Preferred chain | % of Seq | Family | Subtype | Note | % of Seq | Fusion | Antibodies | Name | Type | Modality | Name | Type | D2x50 S3x39 | Sodium in structure | Authors | Reference | PDB Date | |||||
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| CCR8 | CCR8 | Chemokine | A | Human | Cryo-EM | 8XML | - | 2.6 | R | Active | 100 | 63 | Gi/o | αi1 | - | 62 | BRIL | scFv16 |
Apo (no ligand)
|
none | Apo (no ligand) | CCL8, CCL1 | peptide | No | No | - | - | 2025-01-01 | Yes | |
| GPR55 | GPR55 | GPR18, GPR55 and GPR119 | A | Human | Cryo-EM | 9IY8 | 9IY8_refined | 3.0 | R | Active | 100 | 92 | G12/13 | α13 | - | 57 | - | scFv16 |
Apo (no ligand)
|
none | Apo (no ligand) | 2-arachidonoylglycerolphosphoinositol, lysophosphatidylinositol, 2-arachidonoylglycerol, N-palmitoylethanolamine, anandamide | small-molecule | No | No | Chang H, Li X, Shen L, Ge X, Hao S, Wu L, Liu S, Liu J, Cherezov V, Hua T | 10.1038/S41422-024-01046-8 | 2025-01-01 | Yes | |
| GPR55 | GPR55 | GPR18, GPR55 and GPR119 | A | Human | Cryo-EM | 9IYA | - | 3.0 | A | Active | 56 | 86 | - | - | - | - | BRIL | anti-BRIL Fab heavy chain anti-BRIL Fab light chain anti-BRIL Fab Nanobody |
4-(3-Bromo-5-ethoxy-4-hydroxyphenyl)-N-(2-methoxyphenyl)-2-methyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxamide
|
small-molecule | Antagonist | 2-arachidonoylglycerolphosphoinositol, lysophosphatidylinositol, 2-arachidonoylglycerol, N-palmitoylethanolamine, anandamide | small-molecule | No | No | - | - | 2025-01-01 | Yes | |
| LPAR1 | LPA1 | Lysophospholipid (LPA) | A | Human | Cryo-EM | 9IZH | - | 3.0 | R | Active | 100 | 82 | G12/13 | α13 | G13-Gi2 chimera | 56 | BRIL | scFv16 |
lysophosphatidic acid
|
small-molecule | Agonist | 1-O-Oleoyl-D-glycerol 3-phosphoric acid | small-molecule | No | No | Suzuki S, Tanaka K, Kamegawa A, Nishikawa K, Suzuki H, Oshima A, Fujiyoshi Y | 10.1016/J.JSB.2024.108164 | 2025-01-01 | Yes | |
| LPAR1 | LPA1 | Lysophospholipid (LPA) | A | Human | Cryo-EM | 9IZF | - | 3.1 | R | Active | 100 | 80 | Gi/o | αi1 | - | 61 | BRIL | scFv16 |
lysophosphatidic acid
|
small-molecule | Agonist | 1-O-Oleoyl-D-glycerol 3-phosphoric acid | small-molecule | No | No | - | - | 2025-01-01 | Yes | |
| LPAR1 | LPA1 | Lysophospholipid (LPA) | A | Human | Cryo-EM | 9IZG | - | 3.0 | R | Active | 100 | 82 | Gq/11 | αq | Gq-Gs chimera | 57 | BRIL | scFv16 |
lysophosphatidic acid
|
small-molecule | Agonist | 1-O-Oleoyl-D-glycerol 3-phosphoric acid | small-molecule | No | No | - | - | 2025-01-01 | Yes | |
| AA2AR | A2A | Adenosine | A | Human | X-ray | 8UGW | - | 3.9 | A | Active | 69 | 67 | - | - | - | - | T4-Lysozyme | - |
CGS 21680
|
small-molecule | Agonist | adenosine | small-molecule | No | No | - | - | 2024-12-18 | Yes | |
| HCAR3 | HCA3 | Hydroxycarboxylic acid | A | Human | Cryo-EM | 8JEF | 8JEF_refined | 3.0 | A | Active | 100 | 73 | Gi/o | αi1 | - | 61 | - | scFv16 |
3-hydroxyoctanoic acid
|
small-molecule | Agonist | 3-hydroxyoctanoic acid | small-molecule | No | No | Ye F, Pan X, Zhang Z, Xiang X, Li X, Zhang B, Ning P, Liu A, Wang Q, Gong K, Li J, Zhu L, Qian C, Chen G, Du Y | 10.1016/J.CELREP.2024.114895 | 2024-12-18 | Yes | |
| MCHR1 | MCH1 | Melanin-concentrating hormone | A | Human | Cryo-EM | 8YNT | - | 3.4 | R | Inactive | 8 | 69 | - | - | - | - | BRIL | Fab 1B3 heavy chain Fab 1B3 light chain |
CHEMBL242004
|
small-molecule | Antagonist | melanin-concentrating hormone | peptide | No | No | - | - | 2024-12-18 | Yes | |
| MCHR1 | MCH1 | Melanin-concentrating hormone | A | Human | Cryo-EM | 8YNS | - | 3.3 | R | Inactive | 8 | 65 | - | - | - | - | BRIL | Fab 1B3 heavy chain Fab 1B3 light chain |
CHEMBL242004
|
small-molecule | Antagonist | melanin-concentrating hormone | peptide | No | No | - | - | 2024-12-18 | Yes | |
| FFAR1 | FFA1 | Free fatty acid | A | Human | Cryo-EM | 9K1C | 9K1C_refined | 3.2 | R | Active | 100 | 93 | Gi/o | αi1 | - | 62 | - | - |
docosahexaenoic acid
|
small-molecule | Agonist | myristic acid, oleic acid, docosahexaenoic acid, α-linolenic acid | small-molecule | No | No | Ke Y, Huang Y, Yi C, Ma L, Chu X, Wu B, Zhao Q, Han S | 10.1016/J.CELREP.2024.115024 | 2024-12-11 | Yes | |
| FFAR2 | FFA2 | Free fatty acid | A | Human | Cryo-EM | 9K1D | - | 3.3 | R | Active | 100 | 81 | Gi/o | αi1 | - | 62 | - | - |
butyric acid
|
small-molecule | Agonist | butyric acid, acetic acid, trans-2-methylcrotonic acid, propanoic acid | small-molecule | No | No | Ke Y, Huang Y, Yi C, Ma L, Chu X, Wu B, Zhao Q, Han S | 10.1016/J.CELREP.2024.115024 | 2024-12-11 | Yes | |
| MRGRD | MRGPRD | A orphans | A | Human | Cryo-EM | 9DQH | 9DQH_refined | 2.9 | A | Active | 100 | 79 | Gq/11 | αq | Gq-Gs-Gi chimera | 57 | - | scFv16 |
2-[[1-[2-(4-chlorophenyl)-2-methylpropanoyl]piperidin-4-yl]amino]-5,6,7,8-tetrahydro-3H-quinazolin-4-one
|
small-molecule | Agonist | β-alanine | small-molecule | No | No | - | - | 2024-12-11 | Yes | |
| MRGRD | MRGPRD | A orphans | A | Human | Cryo-EM | 9DQJ | 9DQJ_refined | 2.9 | A | Active | 100 | 79 | Gq/11 | αq | Gq-Gs-Gi chimera | 57 | - | scFv16 |
2-[[1-[1-(4-methoxyphenyl)cyclopropanecarbonyl]piperidin-4-yl]amino]-3H-quinazolin-4-one
|
small-molecule | Agonist | β-alanine | small-molecule | No | No | - | - | 2024-12-11 | Yes | |
| S1PR1 | S1P1 | Lysophospholipid (S1P) | A | Human | Cryo-EM | 8YIC | 8YIC_refined | 3.5 | R | Active | 100 | 78 | Gi/o | αi1 | - | 64 | T4-Lysozyme | - |
SAR247799
|
small-molecule | Agonist | dihydrosphingosine 1-phosphate, sphingosylphosphorylcholine, sphingosine 1-phosphate | small-molecule | No | No | - | - | 2024-12-11 | Yes | |
| XCR1 | XCR1 | Chemokine | A | Human | Cryo-EM | 9AST | 9AST_refined | 3.1 | R | Active | 100 | 85 | Gi/o | αi1 | - | 62 | - | scFv16 |
Lymphotactin
|
protein | Agonist | XCL1, XCL2 | peptide | No | No | Zhang X, Schlimgen RR, Singh S, Tomani MP, Volkman BF, Zhang C | 10.1073/PNAS.2405732121 | 2024-12-11 | Yes | |
| APJ | apelin | Apelin | A | Human | X-ray | 8S4D | - | 2.6 | A | Inactive | 16 | 73 | - | - | - | - | BRIL | - |
CMF-019
|
small-molecule | Agonist | apelin-13, apelin-36, apelin-17, Elabela/Toddler-21, Elabela/Toddler-32, Elabela/Toddler-11, apelin receptor early endogenous ligand, [Pyr1]apelin-13 | peptide | No | No | - | - | 2024-12-04 | Yes | |
| GPR6 | GPR6 | A orphans | A | Human | X-ray | 8T1W | - | 3.5 | A | Inactive | 1 | 73 | - | - | - | - | BRIL | - |
CVN424
|
small-molecule | Inverse agonist | sphingosine 1-phosphate | small-molecule | No | No | Barekatain M, Johansson LC, Lam JH, Chang H, Sadybekov AV, Han GW, Russo J, Bliesath J, Brice NL, Carlton MBL, Saikatendu KS, Sun H, Murphy ST, Monenschein H, Schiffer HH, Popov P, Lutomski CA, Robinson CV, Liu ZJ, Hua T, Katritch V, Cherezov V | 10.1126/SCISIGNAL.ADO8741 | 2024-12-04 | Yes | |
| GPR6 | GPR6 | A orphans | A | Human | Cryo-EM | 8TYW | 8TYW_refined | 3.4 | A | Active | 100 | 73 | Gs | αs | - | 60 | - | Nanobody-35 |
Apo (no ligand)
|
none | Apo (no ligand) | sphingosine 1-phosphate | small-molecule | No | No | Barekatain M, Johansson LC, Lam JH, Chang H, Sadybekov AV, Han GW, Russo J, Bliesath J, Brice NL, Carlton MBL, Saikatendu KS, Sun H, Murphy ST, Monenschein H, Schiffer HH, Popov P, Lutomski CA, Robinson CV, Liu ZJ, Hua T, Katritch V, Cherezov V | 10.1126/SCISIGNAL.ADO8741 | 2024-12-04 | Yes | |
| GPR6 | GPR6 | A orphans | A | Human | X-ray | 8T1V | - | 2.6 | A | Inactive | 1 | 73 | - | - | - | - | BRIL | - |
CHEMBL4763822
|
small-molecule | Inverse agonist | sphingosine 1-phosphate | small-molecule | No | No | Barekatain M, Johansson LC, Lam JH, Chang H, Sadybekov AV, Han GW, Russo J, Bliesath J, Brice NL, Carlton MBL, Saikatendu KS, Sun H, Murphy ST, Monenschein H, Schiffer HH, Popov P, Lutomski CA, Robinson CV, Liu ZJ, Hua T, Katritch V, Cherezov V | 10.1126/SCISIGNAL.ADO8741 | 2024-12-04 | Yes | |
| GPR6 | GPR6 | A orphans | A | Human | X-ray | 8TF5 | - | 2.1 | A | Active | 99 | 73 | - | - | - | - | BRIL | - |
oleic acid
|
small-molecule | Inverse agonist | sphingosine 1-phosphate | small-molecule | No | No | Barekatain M, Johansson LC, Lam JH, Chang H, Sadybekov AV, Han GW, Russo J, Bliesath J, Brice NL, Carlton MBL, Saikatendu KS, Sun H, Murphy ST, Monenschein H, Schiffer HH, Popov P, Lutomski CA, Robinson CV, Liu ZJ, Hua T, Katritch V, Cherezov V | 10.1126/SCISIGNAL.ADO8741 | 2024-12-04 | Yes | |
| LGR4 | LGR4 | A orphans | A | Human | Cryo-EM | 8XFT | - | 3.2 | A | Inactive | 8 | 77 | - | - | - | - | - | Nanobody-52 |
R-spondin-2
|
protein | Agonist | R-spondin-3, R-spondin-1, R-spondin-2, R-spondin-4 | peptide | No | No | - | - | 2024-12-04 | Yes | |
| LGR4 | LGR4 | A orphans | A | Human | Cryo-EM | 8XFP | - | 3.2 | A | Inactive | 8 | 77 | - | - | - | - | - | Nanobody-52 |
R-spondin-2
|
protein | Agonist | R-spondin-3, R-spondin-1, R-spondin-2, R-spondin-4 | peptide | No | No | - | - | 2024-12-04 | Yes | |
| LGR4 | LGR4 | A orphans | A | Human | Cryo-EM | 8Y69 | - | 3.4 | D | Inactive | 8 | 77 | - | - | - | - | - | Nanobody-52 |
R-spondin-2
|
protein | Agonist | R-spondin-3, R-spondin-1, R-spondin-2, R-spondin-4 | peptide | No | No | - | - | 2024-12-04 | Yes | |
| LGR4 | LGR4 | A orphans | A | Human | Cryo-EM | 8XFS | - | 3.2 | A | Inactive | 8 | 77 | - | - | - | - | - | Nanobody-52 |
R-spondin-2
|
protein | Agonist | R-spondin-3, R-spondin-1, R-spondin-2, R-spondin-4 | peptide | No | No | - | - | 2024-12-04 | Yes | |
| PD2R2 | DP2 | Prostanoid | A | Human | Cryo-EM | 9IYB | - | 2.8 | A | Active | 100 | 76 | Gi/o | αi1 | - | 64 | - | scFv16 |
PGD2
|
lipid | Agonist | PGD3, PGF2α, PGI2, PGJ2, PGE2, thromboxane A2, PGD2 | small-molecule | No | No | - | - | 2024-12-04 | Yes | |
| PD2R2 | DP2 | Prostanoid | A | Human | Cryo-EM | 8XXV | - | 2.3 | A | Active | 100 | 76 | Gi/o | αi1 | - | 64 | - | scFv16 |
[(2~{R})-1-hexadecanoyloxy-3-[oxidanyl-[(2~{S},3~{R},5~{R},6~{S})-2,3,4,5,6-pentakis(oxidanyl)cyclohexyl]oxy-phosphoryl]oxy-propan-2-yl] (~{Z})-octadec-9-enoate
|
lipid | PAM | PGD3, PGF2α, PGI2, PGJ2, PGE2, thromboxane A2, PGD2 | small-molecule | No | No | - | - | 2024-12-04 | Yes | |
| PD2R2 | DP2 | Prostanoid | A | Human | Cryo-EM | 8XXU | - | 2.5 | A | Active | 100 | 80 | Gi/o | αi1 | - | 64 | - | scFv16 |
[(2~{R})-1-hexadecanoyloxy-3-[oxidanyl-[(2~{S},3~{R},5~{R},6~{S})-2,3,4,5,6-pentakis(oxidanyl)cyclohexyl]oxy-phosphoryl]oxy-propan-2-yl] (~{Z})-octadec-9-enoate
|
lipid | PAM | PGD3, PGF2α, PGI2, PGJ2, PGE2, thromboxane A2, PGD2 | small-molecule | No | No | - | - | 2024-12-04 | Yes | |
| GLP1R | GLP-1 | Glucagon | B1 | Human | Cryo-EM | 9IVG | 9IVG_refined | 3.0 | R | Active | 100 | 83 | Gs | αs | Gs-Gi chimera | 62 | - | Nanobody-35 |
CHEMBL410972
|
protein | Agonist | glucagon-like peptide 1-(7-36) amide, glucagon, glucagon-like peptide 1-(7-37) | peptide | No | No | Li J, Li G, Mai Y, Liu X, Yang D, Zhou Q, Wang MW | 10.1016/J.APSB.2024.09.002 | 2024-11-27 | Yes | |
| GRM2 | mGlu2 | Metabotropic glutamate | C | Human | Cryo-EM | 8WGC | - | 6.0 | D | Active | - | 87 | - | - | - | - | - | - |
LY379268
|
small-molecule | Agonist | L-glutamic acid | small-molecule | No | No | Huang W, Jin N, Guo J, Shen C, Xu C, Xi K, Bonhomme L, Quast RB, Shen DD, Qin J, Liu YR, Song Y, Gao Y, Margeat E, Rondard P, Pin JP, Zhang Y, Liu J | 10.1038/S41467-024-54744-7 | 2024-11-27 | Yes | |
| GRM4 | mGlu4 | Metabotropic glutamate | C | Human | Cryo-EM | 8WGD | - | 4.5 | B | Inactive | - | 82 | - | - | - | - | - | - |
(2S)-2-azanyl-2-cyclopropyl-2-(4-phosphonophenyl)ethanoic acid
|
small-molecule | Antagonist | L-serine-O-phosphate, L-glutamic acid | small-molecule | No | No | - | - | 2024-11-27 | Yes | |
| GRM4 | mGlu4 | Metabotropic glutamate | C | Human | Cryo-EM | 8WG9 | - | 4.5 | B | Active | - | 85 | - | - | - | - | - | - |
L-AP4
|
small-molecule | Agonist | L-serine-O-phosphate, L-glutamic acid | small-molecule | No | No | - | - | 2024-11-27 | Yes | |
| LPAR1 | LPA1 | Lysophospholipid (LPA) | A | Human | Cryo-EM | 9J5V | - | 2.9 | R | Active | 100 | 80 | Gi/o | αi1 | - | 63 | - | scFv16 |
CpY
|
small-molecule | Agonist | 1-O-Oleoyl-D-glycerol 3-phosphoric acid | small-molecule | No | No | - | - | 2024-11-27 | Yes | |
| OPRD | δ | Opioid | A | Human | Cryo-EM | 8Y45 | 8Y45_refined | 3.5 | A | Active | 100 | 77 | Gi/o | αi2 | - | 63 | - | scFv16 |
ADL5859
|
small-molecule | Agonist | dynorphin B, dynorphin A-(1-13), dynorphin A-(1-8), β-endorphin, α-neoendorphin, [Met]enkephalin, dynorphin A, [Leu]enkephalin, endomorphin-1 | peptide | No | No | - | - | 2024-11-27 | Yes | |
| T2R14 | TAS2R14 | Taste 2 | T2 | Human | Cryo-EM | 8RQL | - | 3.0 | R | Active | 100 | 88 | Gi/o | αgust | - | 61 | - | scFv16 |
flufenamic acid
|
small-molecule | Agonist | - | - | No | No | Peri L, Matzov D, Huxley DR, Rainish A, Fierro F, Sapir L, Pfeiffer T, Waterloo L, Hubner H, Peleg Y, Gmeiner P, McCormick PJ, Weikert D, Niv MY, Shalev-Benami M | 10.1038/S41467-024-54157-6 | 2024-11-27 | Yes | |
| CNR1 | CB1 | Cannabinoid | A | Human | Cryo-EM | 9BA0 | - | 3.1 | R | Inactive | 7 | 60 | - | - | - | - | Glycogen synthase | Nanobody-36 |
Monlunabant
|
small-molecule | Inverse agonist | 2-arachidonoylglycerol, anandamide | small-molecule | No | No | - | - | 2024-11-20 | Yes | |
| CNR1 | CB1 | Cannabinoid | A | Human | Cryo-EM | 9B9Y | - | 3.5 | R | Inactive | 7 | 60 | - | - | - | - | Glycogen synthase | Nanobody-36 |
taranabant
|
small-molecule | Inverse agonist | 2-arachidonoylglycerol, anandamide | small-molecule | No | No | Kumari P, Dvoracsko S, Enos MD, Ramesh K, Lim D, Hassan SA, Kunos G, Cinar R, Iyer MR, Rosenbaum DM | 10.1038/S41467-024-54206-0 | 2024-11-20 | Yes | |
| CNR1 | CB1 | Cannabinoid | A | Human | Cryo-EM | 9B9Z | - | 3.3 | R | Inactive | 7 | 60 | - | - | - | - | Glycogen synthase | Nanobody-36 |
Zevaquenabant
|
small-molecule | Inverse agonist | 2-arachidonoylglycerol, anandamide | small-molecule | No | No | - | - | 2024-11-20 | Yes | |
| CNR2 | CB2 | Cannabinoid | A | Human | Cryo-EM | 8X3L | 8X3L_refined | 3.1 | R | Active | 100 | 80 | Gi/o | αi1 | - | 62 | - | scFv16 |
CHEMBL5422946
|
small-molecule | Agonist | 2-arachidonoylglycerol, anandamide | small-molecule | No | No | Yang X, Zhou P, Shen S, Hu Q, Tian C, Xia A, Wang Y, Yang Z, Nan J, Zhou Y, Chen S, Tian X, Wu C, Lin G, Zhang L, Wang K, Zheng T, Zou J, Yan W, Shao Z, Yang S | 10.1073/PNAS.2401091121 | 2024-11-20 | Yes | |
| HCAR3 | HCA3 | Hydroxycarboxylic acid | A | Human | Cryo-EM | 8JEI | - | 2.7 | A | Active | 100 | 74 | Gi/o | αi1 | - | 61 | - | scFv16 |
4-(n-propyl)amino-3-nitrobenzoic acid
|
small-molecule | Agonist | 3-hydroxyoctanoic acid | small-molecule | No | No | Ye F, Pan X, Zhang Z, Xiang X, Li X, Zhang B, Ning P, Liu A, Wang Q, Gong K, Li J, Zhu L, Qian C, Chen G, Du Y | 10.1016/J.CELREP.2024.114895 | 2024-11-20 | Yes | |
| OPSD | Rhodopsin | Opsins | A | Bovine | Cryo-EM | 8P13 | - | 5.2 | R | Active | 100 | 91 | Gi/o | αi1 | - | 94 | - | Fab heavy chain Fab light chain scFv16 |
Apo (no ligand)
|
none | Apo (no ligand) | - | - | No | No | - | - | 2024-11-20 | Yes | |
| OPSD | Rhodopsin | Opsins | A | Bovine | Cryo-EM | 8P12 | - | 3.2 | R | Active | 100 | 91 | Gi/o | αi1 | - | 59 | - | Fab heavy chain Fab light chain |
Apo (no ligand)
|
none | Apo (no ligand) | - | - | No | No | - | - | 2024-11-20 | Yes | |
| OPSD | Rhodopsin | Opsins | A | Bovine | Cryo-EM | 8P15 | - | 5.9 | R | Active | 100 | 92 | Gi/o | αi1 | - | 96 | - | Fab heavy chain Fab light chain scFv16 |
Apo (no ligand)
|
none | Apo (no ligand) | - | - | No | No | - | - | 2024-11-20 | Yes | |
| ADRB2 | β2 | Adrenoceptors | A | Human | Cryo-EM | 9CHV | - | 4.0 | A | Intermediate | 47 | 63 | - | - | - | - | - | - |
Apo (no ligand)
|
none | Apo (no ligand) | Zn2+, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline | small-molecule | No | No | Xu J, Chen G, Wang H, Cao S, Heng J, Deupi X, Du Y, Kobilka BK | 10.1073/PNAS.2414544121 | 2024-11-13 | Yes | |
| ADRB2 | β2 | Adrenoceptors | A | Human | Cryo-EM | 9CHU | - | 3.5 | A | Intermediate | 47 | 66 | - | - | - | - | - | - |
Noradrenaline
|
small-molecule | Agonist | Zn2+, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline | small-molecule | No | No | Xu J, Chen G, Wang H, Cao S, Heng J, Deupi X, Du Y, Kobilka BK | 10.1073/PNAS.2414544121 | 2024-11-13 | Yes | |
| ADRB2 | β2 | Adrenoceptors | A | Human | Cryo-EM | 9CHX | - | 3.5 | A | Intermediate | 47 | 67 | - | - | - | - | - | - |
Carazolol
|
small-molecule | Inverse agonist | Zn2+, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline | small-molecule | No | No | Xu J, Chen G, Wang H, Cao S, Heng J, Deupi X, Du Y, Kobilka BK | 10.1073/PNAS.2414544121 | 2024-11-13 | Yes | |
| GLP1R | GLP-1 | Glucagon | B1 | Human | Cryo-EM | 9IVM | - | 3.2 | R | Active | 100 | 83 | Gs | αs | Gs-Gi chimera | 62 | - | Nanobody-35 |
CHEMBL410972
LSN3318839 |
protein small-molecule |
Agonist PAM |
glucagon-like peptide 1-(7-36) amide, glucagon, glucagon-like peptide 1-(7-37) | peptide | No | No | - | - | 2024-11-13 | Yes | |
| GPR55 | GPR55 | GPR18, GPR55 and GPR119 | A | Human | Cryo-EM | 8ZX5 | - | 3.0 | R | Active | 100 | 88 | G12/13 | α13 | - | 56 | - | - |
AM251
|
small-molecule | Agonist | 2-arachidonoylglycerolphosphoinositol, lysophosphatidylinositol, 2-arachidonoylglycerol, N-palmitoylethanolamine, anandamide | small-molecule | No | No | - | - | 2024-11-13 | Yes | |
| GPR55 | GPR55 | GPR18, GPR55 and GPR119 | A | Human | Cryo-EM | 8ZX4 | - | 2.9 | R | Active | 100 | 90 | G12/13 | α13 | - | 56 | - | - |
LPI
|
small-molecule | Agonist | 2-arachidonoylglycerolphosphoinositol, lysophosphatidylinositol, 2-arachidonoylglycerol, N-palmitoylethanolamine, anandamide | small-molecule | No | No | - | - | 2024-11-13 | Yes | |
| MCHR1 | MCH1 | Melanin-concentrating hormone | A | Human | Cryo-EM | 8WWI | 8WWI_refined | 3.4 | R | Active | 100 | 68 | Gi/o | αi1 | - | 63 | - | scFv16 |
Apo (no ligand)
|
none | Apo (no ligand) | melanin-concentrating hormone | peptide | No | No | - | - | 2024-11-13 | Yes | |
| MCHR1 | MCH1 | Melanin-concentrating hormone | A | Human | Cryo-EM | 8WWM | 8WWM_refined | 2.8 | R | Active | 100 | 68 | Gi/o | αi1 | - | 63 | - | scFv16 |
Melanin-concentrating hormone
|
peptide | Agonist | melanin-concentrating hormone | peptide | No | No | Ye X, Liu G, Li X, He B, Tao Y, Guan J, Mu Y, Liu H, Gong W | 10.1038/S41421-024-00754-0 | 2024-11-13 | Yes | |
| MCHR1 | MCH1 | Melanin-concentrating hormone | A | Human | Cryo-EM | 8WWK | 8WWK_refined | 2.6 | R | Active | 100 | 68 | Gi/o | αi1 | - | 63 | - | scFv16 |
Melanin-concentrating hormone
|
peptide | Agonist | melanin-concentrating hormone | peptide | No | No | Ye X, Liu G, Li X, He B, Tao Y, Guan J, Mu Y, Liu H, Gong W | 10.1038/S41421-024-00754-0 | 2024-11-13 | Yes | |
| MCHR1 | MCH1 | Melanin-concentrating hormone | A | Human | Cryo-EM | 8WWN | 8WWN_refined | 2.7 | R | Active | 100 | 68 | Gi/o | αi1 | - | 63 | - | scFv16 |
Melanin-concentrating hormone
|
peptide | Agonist | melanin-concentrating hormone | peptide | No | No | Ye X, Liu G, Li X, He B, Tao Y, Guan J, Mu Y, Liu H, Gong W | 10.1038/S41421-024-00754-0 | 2024-11-13 | Yes | |
| MCHR1 | MCH1 | Melanin-concentrating hormone | A | Human | Cryo-EM | 8WWJ | - | 3.0 | R | Active | 100 | 68 | Gi/o | αi1 | - | 63 | - | scFv16 |
Apo (no ligand)
|
none | Apo (no ligand) | melanin-concentrating hormone | peptide | No | No | - | - | 2024-11-13 | Yes | |
| MCHR1 | MCH1 | Melanin-concentrating hormone | A | Human | Cryo-EM | 8WWL | 8WWL_refined | 2.8 | R | Active | 100 | 68 | Gi/o | αi1 | - | 63 | - | scFv16 |
Melanin-concentrating hormone
|
peptide | Agonist | melanin-concentrating hormone | peptide | No | No | Ye X, Liu G, Li X, He B, Tao Y, Guan J, Mu Y, Liu H, Gong W | 10.1038/S41421-024-00754-0 | 2024-11-13 | Yes | |
| MCHR1 | MCH1 | Melanin-concentrating hormone | A | Human | Cryo-EM | 8WWH | 8WWH_refined | 2.8 | R | Active | 100 | 68 | Gi/o | αi1 | - | 63 | - | scFv16 |
Apo (no ligand)
|
none | Apo (no ligand) | melanin-concentrating hormone | peptide | No | No | - | - | 2024-11-13 | Yes | |
| PTAFR | PAF | Platelet-activating factor | A | Human | Cryo-EM | 8XYD | 8XYD_refined | 2.9 | A | Active | 100 | 89 | Gi/o | αi1 | - | 61 | - | scFv16 |
PAF
|
small-molecule | Agonist | PAF | small-molecule | No | No | Fan W, Xu Y, He X, Luo P, Zhu J, Li J, Wang R, Yuan Q, Wu K, Hu W, Zhao Y, Xu S, Cheng X, Wang Y, Xu HE, Zhuang Y | 10.1016/J.CELREP.2024.114422 | 2024-11-13 | Yes | |
| GRM5 | mGlu5 | Metabotropic glutamate | C | Human | Cryo-EM | 8X0C | - | 3.2 | A | Active | - | 63 | - | - | - | - | - | - |
quisqualate
VU0424465 |
small-molecule small-molecule |
Agonist PAM |
L-glutamic acid | small-molecule | No | No | Cannone G, Berto L, Malhaire F, Ferguson G, Fouillen A, Balor S, Font-Ingles J, Llebaria A, Goudet C, Kotecha A, K R V, Lebon G | 10.1038/S41467-024-55439-9 | 2024-11-06 | Yes | |
| GRM5 | mGlu5 | Metabotropic glutamate | C | Human | Cryo-EM | 8X0B | - | 3.1 | A | Active | - | 64 | - | - | - | - | - | - |
quisqualate
VU0424465 |
small-molecule small-molecule |
Agonist PAM |
L-glutamic acid | small-molecule | No | No | Cannone G, Berto L, Malhaire F, Ferguson G, Fouillen A, Balor S, Font-Ingles J, Llebaria A, Goudet C, Kotecha A, K R V, Lebon G | 10.1038/S41467-024-55439-9 | 2024-11-06 | Yes | |
| GRM5 | mGlu5 | Metabotropic glutamate | C | Human | Cryo-EM | 8X0D | - | 3.5 | A | Active | - | 63 | - | - | - | - | - | - |
quisqualate
VU0424465 |
small-molecule small-molecule |
Agonist PAM |
L-glutamic acid | small-molecule | No | No | Cannone G, Berto L, Malhaire F, Ferguson G, Fouillen A, Balor S, Font-Ingles J, Llebaria A, Goudet C, Kotecha A, K R V, Lebon G | 10.1038/S41467-024-55439-9 | 2024-11-06 | Yes | |
| GRM5 | mGlu5 | Metabotropic glutamate | C | Human | Cryo-EM | 8X0H | - | 4.1 | A | Active | - | 64 | - | - | - | - | - | - |
quisqualate
|
small-molecule | Agonist | L-glutamic acid | small-molecule | No | No | Cannone G, Berto L, Malhaire F, Ferguson G, Fouillen A, Balor S, Font-Ingles J, Llebaria A, Goudet C, Kotecha A, K R V, Lebon G | 10.1038/S41467-024-55439-9 | 2024-11-06 | Yes | |
| GRM5 | mGlu5 | Metabotropic glutamate | C | Human | Cryo-EM | 8X0G | - | 3.0 | A | Active | - | 63 | - | - | - | - | - | - |
quisqualate
|
small-molecule | Agonist | L-glutamic acid | small-molecule | No | No | Cannone G, Berto L, Malhaire F, Ferguson G, Fouillen A, Balor S, Font-Ingles J, Llebaria A, Goudet C, Kotecha A, K R V, Lebon G | 10.1038/S41467-024-55439-9 | 2024-11-06 | Yes | |
| GRM5 | mGlu5 | Metabotropic glutamate | C | Human | Cryo-EM | 8X0F | - | 3.3 | A | Active | - | 63 | - | - | - | - | - | - |
quisqualate
VU-29 |
small-molecule small-molecule |
Agonist PAM |
L-glutamic acid | small-molecule | No | No | Cannone G, Berto L, Malhaire F, Ferguson G, Fouillen A, Balor S, Font-Ingles J, Llebaria A, Goudet C, Kotecha A, K R V, Lebon G | 10.1038/S41467-024-55439-9 | 2024-11-06 | Yes | |
| GRM5 | mGlu5 | Metabotropic glutamate | C | Human | Cryo-EM | 8X0E | - | 3.4 | A | Active | - | 63 | - | - | - | - | - | - |
quisqualate
|
small-molecule | Agonist | L-glutamic acid | small-molecule | No | No | Cannone G, Berto L, Malhaire F, Ferguson G, Fouillen A, Balor S, Font-Ingles J, Llebaria A, Goudet C, Kotecha A, K R V, Lebon G | 10.1038/S41467-024-55439-9 | 2024-11-06 | Yes | |
| MRGX4 | MRGPRX4 | A orphans | A | Human | Cryo-EM | 8KEX | - | 3.2 | E | Active | 98 | 79 | - | - | - | - | BRIL | - |
DCA-3P
|
small-molecule | Agonist | - | - | No | No | Yang J, Zhao T, Fan J, Zou H, Lan G, Guo F, Shi Y, Ke H, Yu H, Yue Z, Wang X, Bai Y, Li S, Liu Y, Wang X, Chen Y, Li Y, Lei X | 10.1016/J.CELL.2024.10.001 | 2024-11-06 | Yes | |
| MRGX4 | MRGPRX4 | A orphans | A | Human | Cryo-EM | 8K4S | 8K4S_refined | 2.9 | E | Active | 100 | 79 | Gq/11 | αq | Gq-Gs chimera | 57 | BRIL | scFv16 |
DCA-3P
|
small-molecule | Agonist | - | - | No | No | Yang J, Zhao T, Fan J, Zou H, Lan G, Guo F, Shi Y, Ke H, Yu H, Yue Z, Wang X, Bai Y, Li S, Liu Y, Wang X, Chen Y, Li Y, Lei X | 10.1016/J.CELL.2024.10.001 | 2024-11-06 | Yes | |
| B1B1U5 | Rhodopsin | Opsins | A | Hasarius adansoni | Cryo-EM | 9EPR | - | 4.9 | R | Active | 100 | 89 | Gi/o | αi1 | - | 60 | - | - |
Retinal (11-cis)
|
small-molecule | Agonist | - | - | No | No | Tejero O, Pamula F, Koyanagi M, Nagata T, Afanasyev P, Das I, Deupi X, Sheves M, Terakita A, Schertler GFX, Rodrigues MJ, Tsai CJ | 10.1038/S41467-024-53208-2 | 2024-10-30 | Yes | |
| GP119 | GPR119 | GPR18, GPR55 and GPR119 | A | Human | Cryo-EM | 8VHF | 8VHF_refined | 3.5 | R | Active | 100 | 88 | Gs | αs | - | 60 | BRIL | Nanobody-35 |
MBX-2982
|
small-molecule | Agonist | N-oleoylethanolamide, N-palmitoylethanolamine, SEA, anandamide | small-molecule | No | No | - | - | 2024-10-30 | Yes | |
| GRM2 | mGlu2 | Metabotropic glutamate | C | Human | Cryo-EM | 8WGB | - | 3.7 | B | Active | - | 83 | Gi/o | αi3 | - | 63 | - | - |
VU0155041
|
small-molecule | Agonist | L-glutamic acid | small-molecule | No | No | Huang W, Jin N, Guo J, Shen C, Xu C, Xi K, Bonhomme L, Quast RB, Shen DD, Qin J, Liu YR, Song Y, Gao Y, Margeat E, Rondard P, Pin JP, Zhang Y, Liu J | 10.1038/S41467-024-54744-7 | 2024-10-30 | Yes | |
| KISSR | kisspeptin | Kisspeptin | A | Human | Cryo-EM | 8XGS | - | 3.0 | A | Active | 100 | 74 | Gq/11 | αq | - | 64 | - | scFv16 |
Kisspeptin-10
|
peptide | Agonist | kisspeptin-13, kisspeptin-54, kisspeptin-14, kisspeptin-52, kisspeptin-10 | peptide | No | No | Wu Z, Chen G, Qiu C, Yan X, Xu L, Jiang S, Xu J, Han R, Shi T, Liu Y, Gao W, Wang Q, Li J, Ye F, Pan X, Zhang Z, Ning P, Zhang B, Chen J, Du Y | 10.1126/SCIADV.ADN7771 | 2024-10-30 | Yes | |
| KISSR | kisspeptin | Kisspeptin | A | Human | Cryo-EM | 8XGO | - | 2.7 | A | Active | 100 | 75 | Gq/11 | αq | - | 64 | - | scFv16 |
TAK448
|
peptide | Agonist | kisspeptin-13, kisspeptin-54, kisspeptin-14, kisspeptin-52, kisspeptin-10 | peptide | No | No | Wu Z, Chen G, Qiu C, Yan X, Xu L, Jiang S, Xu J, Han R, Shi T, Liu Y, Gao W, Wang Q, Li J, Ye F, Pan X, Zhang Z, Ning P, Zhang B, Chen J, Du Y | 10.1126/SCIADV.ADN7771 | 2024-10-30 | Yes | |
| KISSR | kisspeptin | Kisspeptin | A | Human | Cryo-EM | 8XGU | - | 3.0 | A | Active | 100 | 72 | Gi/o | αi1 | - | 60 | - | scFv16 |
ACY-DTY-HYP-ASN-THR-PHE-XZA-LEU-NMM-TRP-NH2
|
peptide | Agonist | kisspeptin-13, kisspeptin-54, kisspeptin-14, kisspeptin-52, kisspeptin-10 | peptide | No | No | Wu Z, Chen G, Qiu C, Yan X, Xu L, Jiang S, Xu J, Han R, Shi T, Liu Y, Gao W, Wang Q, Li J, Ye F, Pan X, Zhang Z, Ning P, Zhang B, Chen J, Du Y | 10.1126/SCIADV.ADN7771 | 2024-10-30 | Yes | |
| LGR4 | LGR4 | A orphans | A | Human | Cryo-EM | 8WVW | - | 3.5 | A | Inactive | 8 | 76 | - | - | - | - | - | - |
Apo (no ligand)
|
none | Apo (no ligand) | R-spondin-3, R-spondin-1, R-spondin-2, R-spondin-4 | peptide | No | No | - | - | 2024-10-30 | Yes | |
| LGR4 | LGR4 | A orphans | A | Human | Cryo-EM | 8WVU | - | 3.6 | A | Inactive | 8 | 77 | - | - | - | - | - | - |
R-spondin-1
|
protein | Agonist | R-spondin-3, R-spondin-1, R-spondin-2, R-spondin-4 | peptide | No | No | - | - | 2024-10-30 | Yes | |
| LGR4 | LGR4 | A orphans | A | Human | Cryo-EM | 8WVV | - | 3.4 | A | Inactive | 8 | 75 | - | - | - | - | - | - |
Apo (no ligand)
|
none | Apo (no ligand) | R-spondin-3, R-spondin-1, R-spondin-2, R-spondin-4 | peptide | No | No | - | - | 2024-10-30 | Yes | |
| LGR4 | LGR4 | A orphans | A | Human | Cryo-EM | 8WVX | - | 3.3 | A | Inactive | 8 | 76 | - | - | - | - | - | - |
Norrin
|
peptide | Agonist | R-spondin-3, R-spondin-1, R-spondin-2, R-spondin-4 | peptide | No | No | - | - | 2024-10-30 | Yes | |
| LGR4 | LGR4 | A orphans | A | Human | Cryo-EM | 8WVY | - | 3.3 | A | Inactive | 8 | 77 | - | - | - | - | - | - |
Norrin
|
peptide | Agonist | R-spondin-3, R-spondin-1, R-spondin-2, R-spondin-4 | peptide | No | No | - | - | 2024-10-30 | Yes | |
| O51G2 | OR51G2 | Odorant family 51 | O1 | Human | Cryo-EM | 8UXV | - | 3.2 | A | Active | - | 96 | Gs | αs | Mini-Gs | 56 | - | Nanobody-35 |
Apo (no ligand)
|
none | Apo (no ligand) | - | - | No | No | de March CA, Ma N, Billesbolle CB, Tewari J, Llinas Del Torrent C, van der Velden WJC, Ojiro I, Takayama I, Faust B, Li L, Vaidehi N, Manglik A, Matsunami H | 10.1038/S41586-024-08126-0 | 2024-10-30 | Yes | |
| OR1F1 | OR1F1 | Odorant family 1 | O2 | Human | Cryo-EM | 8UXY | - | 3.3 | A | Active | - | 94 | Gs | αs | Mini-Gs | 56 | - | Nanobody-35 |
l-Menthol
|
small-molecule | Agonist | - | - | No | No | de March CA, Ma N, Billesbolle CB, Tewari J, Llinas Del Torrent C, van der Velden WJC, Ojiro I, Takayama I, Faust B, Li L, Vaidehi N, Manglik A, Matsunami H | 10.1038/S41586-024-08126-0 | 2024-10-30 | Yes | |
| OR2T2 | OR2T2 | Odorant family 2 | O2 | Human | Cryo-EM | 8UY0 | - | 3.2 | A | Active | - | 89 | Gs | αs | Mini-Gs | 55 | - | Nanobody-35 |
(5S)-2-methyl-5-(prop-1-en-2-yl)cyclohex-2-en-1-one
|
small-molecule | Agonist | - | - | No | No | de March CA, Ma N, Billesbolle CB, Tewari J, Llinas Del Torrent C, van der Velden WJC, Ojiro I, Takayama I, Faust B, Li L, Vaidehi N, Manglik A, Matsunami H | 10.1038/S41586-024-08126-0 | 2024-10-30 | Yes | |
| OR4D5 | OR4D5 | Odorant family 4 | O2 | Human | Cryo-EM | 8UYQ | - | 3.5 | A | Active | - | 93 | Gs | αs | Mini-Gs | 55 | - | Nanobody-35 |
(2R)-2-methyl-1,3-thiazolidine
|
small-molecule | Agonist | - | - | No | No | de March CA, Ma N, Billesbolle CB, Tewari J, Llinas Del Torrent C, van der Velden WJC, Ojiro I, Takayama I, Faust B, Li L, Vaidehi N, Manglik A, Matsunami H | 10.1038/S41586-024-08126-0 | 2024-10-30 | Yes | |
| B1B1U5 | Rhodopsin | Opsins | A | Hasarius adansoni | Cryo-EM | 9EPQ | - | 4.2 | R | Active | 100 | 86 | Gi/o | αi1 | - | 65 | - | - |
11,20-Ethanoretinal
|
small-molecule | Agonist | - | - | No | No | - | - | 2024-10-23 | Yes | |
| B1B1U5 | Rhodopsin | Opsins | A | Hasarius adansoni | Cryo-EM | 9EPP | - | 4.1 | R | Active | 100 | 87 | Gi/o | αi1 | - | 63 | - | - |
11,20-Ethanoretinal
|
small-molecule | Agonist | - | - | No | No | - | - | 2024-10-23 | Yes | |
| HRH3 | H3 | Histamine | A | Human | Cryo-EM | 8YN7 | - | 2.8 | R | Active | 100 | 64 | Gi/o | αo | Mini-Go | 61 | - | scFv16 |
[(2R)-3-[(E)-hexadec-9-enoyl]oxy-2-octadecanoyloxypropyl] 2-(trimethylazaniumyl)ethyl phosphate
|
lipid | Agonist | histamine | small-molecule | No | No | - | - | 2024-10-16 | Yes | |
| HRH3 | H3 | Histamine | A | Human | Cryo-EM | 8YN8 | - | 2.8 | R | Active | 100 | 64 | Gi/o | αo | Mini-Go | 61 | - | scFv16 |
proxyfan
|
small-molecule | Agonist | histamine | small-molecule | No | No | - | - | 2024-10-16 | Yes | |
| PTH1R | PTH1 | Parathyroid hormone | B1 | Human | Cryo-EM | 9JR3 | - | 2.8 | R | Active | 100 | 60 | Gq/11 | αq | Mini-Gq | 57 | - | scFv16 |
Parathyroid hormone
|
peptide | Agonist | PTH, PTHrP, TIP39, PTHrP-(1-36) | peptide | No | No | - | - | 2024-10-16 | Yes | |
| PTH1R | PTH1 | Parathyroid hormone | B1 | Human | Cryo-EM | 9JR2 | - | 2.8 | R | Active | 100 | 59 | Gq/11 | αq | Mini-Gq | 57 | - | scFv16 |
Parathyroid hormone
|
peptide | Agonist | PTH, PTHrP, TIP39, PTHrP-(1-36) | peptide | No | No | - | - | 2024-10-16 | Yes | |
| TAAR1 | TA1 | Trace amine | A | Human | Cryo-EM | 9JKQ | 9JKQ_refined | 2.7 | R | Active | 100 | 87 | Gs | αs | - | 60 | BRIL | Nanobody-35 |
METHAMPHETAMINE
|
small-molecule | Agonist | tyramine, (+)-Octopamine, octopamine, β-phenylethylamine, CHEMBL1160703, 3-iodothyronamine, dopamine | small-molecule | No | No | Lin Y, Wang J, Shi F, Yang L, Wu S, Qiao A, Ye S | 10.1021/ACS.JMEDCHEM.4C01961 | 2024-10-16 | Yes | |
| GPBAR | GPBA | Bile acid | A | Human | Cryo-EM | 9GYO | - | 2.5 | R | Active | 100 | 83 | Gs | αs | Mini-Gs | 59 | BRIL | Nanobody-35 |
CHEMBL2331646
|
small-molecule | Agonist | lithocholic acid, deoxycholic acid, cholic acid, chenodeoxycholic acid | small-molecule | No | No | - | - | 2024-10-09 | Yes | |
| HRH1 | H1 | Histamine | A | Human | Cryo-EM | 8YN2 | - | 2.7 | R | Active | 100 | 56 | Gq/11 | αq | Mini-Gq | 64 | - | scFv16 |
histamine
|
small-molecule | Agonist | histamine | small-molecule | No | No | Zhang X, Liu G, Zhong YN, Zhang R, Yang CC, Niu C, Pu X, Sun J, Zhang T, Yang L, Zhang C, Li X, Shen X, Xiao P, Sun JP, Gong W | 10.1038/S41467-024-52585-Y | 2024-10-09 | Yes | |
| HRH2 | H2 | Histamine | A | Human | Cryo-EM | 8YN4 | - | 3.0 | R | Active | 100 | 75 | Gq/11 | αq | Mini-Gq | 64 | - | scFv16 |
histamine
|
small-molecule | Agonist | histamine | small-molecule | No | No | Zhang X, Liu G, Zhong YN, Zhang R, Yang CC, Niu C, Pu X, Sun J, Zhang T, Yang L, Zhang C, Li X, Shen X, Xiao P, Sun JP, Gong W | 10.1038/S41467-024-52585-Y | 2024-10-09 | Yes | |
| HRH2 | H2 | Histamine | A | Human | Cryo-EM | 8YN3 | - | 2.6 | R | Active | 100 | 78 | Gs | αs | Mini-Gq | 60 | - | Nanobody-35 |
histamine
|
small-molecule | Agonist | histamine | small-molecule | No | No | Zhang X, Liu G, Zhong YN, Zhang R, Yang CC, Niu C, Pu X, Sun J, Zhang T, Yang L, Zhang C, Li X, Shen X, Xiao P, Sun JP, Gong W | 10.1038/S41467-024-52585-Y | 2024-10-09 | Yes | |
| HRH3 | H3 | Histamine | A | Human | Cryo-EM | 8YN6 | - | 2.8 | R | Active | 100 | 65 | Gi/o | αi1 | - | 63 | - | scFv16 |
imetit
|
small-molecule | Agonist | histamine | small-molecule | No | No | Zhang X, Liu G, Zhong YN, Zhang R, Yang CC, Niu C, Pu X, Sun J, Zhang T, Yang L, Zhang C, Li X, Shen X, Xiao P, Sun JP, Gong W | 10.1038/S41467-024-52585-Y | 2024-10-09 | Yes | |
| HRH3 | H3 | Histamine | A | Human | Cryo-EM | 8YN5 | - | 2.7 | R | Active | 100 | 65 | Gi/o | αi1 | - | 63 | - | scFv16 |
histamine
|
small-molecule | Agonist | histamine | small-molecule | No | No | Zhang X, Liu G, Zhong YN, Zhang R, Yang CC, Niu C, Pu X, Sun J, Zhang T, Yang L, Zhang C, Li X, Shen X, Xiao P, Sun JP, Gong W | 10.1038/S41467-024-52585-Y | 2024-10-09 | Yes | |
| HRH4 | H4 | Histamine | A | Human | Cryo-EM | 8YN9 | - | 2.3 | R | Active | 100 | 71 | Gi/o | αi1 | - | 63 | - | scFv16 |
histamine
|
small-molecule | Agonist | histamine, CCL16 | small-molecule | No | No | Zhang X, Liu G, Zhong YN, Zhang R, Yang CC, Niu C, Pu X, Sun J, Zhang T, Yang L, Zhang C, Li X, Shen X, Xiao P, Sun JP, Gong W | 10.1038/S41467-024-52585-Y | 2024-10-09 | Yes | |
| HRH4 | H4 | Histamine | A | Human | Cryo-EM | 8YNA | - | 2.6 | R | Active | 100 | 71 | Gi/o | αi1 | - | 63 | - | scFv16 |
immepip
|
small-molecule | Agonist | histamine, CCL16 | small-molecule | No | No | - | - | 2024-10-09 | Yes | |
| CASR | CaS | Calcium-sensing | C | Human | Cryo-EM | 9C1P | - | 2.8 | A | Inactive | - | 72 | - | - | - | - | - | - |
(5R)-N-[2-(1,2-benzothiazol-3-yl)ethyl]-1-methyl-2,3,4,5-tetrahydro-1H-1-benzazepin-5-amine
|
small-molecule | PAM | Mg2+, L-tryptophan, spermine, Ca2+ | small-molecule | No | No | - | - | 2024-10-02 | Yes | |
| CASR | CaS | Calcium-sensing | C | Human | Cryo-EM | 9C2F | - | 2.8 | A | Inactive | - | 71 | - | - | - | - | - | - |
(1R)-1-(2H-1,3-benzodioxol-4-yl)-N-[2-(1,2-benzothiazol-3-yl)ethyl]ethan-1-amine
|
small-molecule | PAM | Mg2+, L-tryptophan, spermine, Ca2+ | small-molecule | No | No | - | - | 2024-10-02 | Yes | |
| EDNRB | ETB | Endothelin | A | Human | Cryo-EM | 8ZRT | - | 3.6 | R | Active | 83 | 64 | - | - | - | - | - | - |
ENDOTHELIN
|
protein | Agonist | endothelin-2, endothelin-3, endothelin-1 | peptide | No | No | Tani K, Maki-Yonekura S, Kanno R, Negami T, Hamaguchi T, Hall M, Mizoguchi A, Humbel BM, Terada T, Yonekura K, Doi T | 10.1038/S42003-024-06905-Z | 2024-10-02 | Yes | |
| EDNRB | ETB | Endothelin | A | Human | Cryo-EM | 8XWP | 8XWP_refined | 3.2 | R | Active | 100 | 68 | Gi/o | αi1 | - | 62 | - | scFv16 |
ENDOTHELIN
|
protein | Agonist | endothelin-2, endothelin-3, endothelin-1 | peptide | No | No | Tani K, Maki-Yonekura S, Kanno R, Negami T, Hamaguchi T, Hall M, Mizoguchi A, Humbel BM, Terada T, Yonekura K, Doi T | 10.1038/S42003-024-06905-Z | 2024-10-02 | Yes | |
| EDNRB | ETB | Endothelin | A | Human | Cryo-EM | 8XWQ | - | 4.6 | R | Active | 100 | 68 | Gi/o | αi1 | - | 62 | - | scFv16 |
ENDOTHELIN
|
protein | Agonist | endothelin-2, endothelin-3, endothelin-1 | peptide | No | No | Tani K, Maki-Yonekura S, Kanno R, Negami T, Hamaguchi T, Hall M, Mizoguchi A, Humbel BM, Terada T, Yonekura K, Doi T | 10.1038/S42003-024-06905-Z | 2024-10-02 | Yes | |
| FZD7 | FZD7 | Frizzled | F | Human | Cryo-EM | 9EW2 | - | 3.2 | R | Active | 100 | 59 | Gs | αs | - | 59 | - | Nanobody-35 |
Apo (no ligand)
|
none | Apo (no ligand) | - | - | No | No | - | - | 2024-10-02 | Yes | |
| FZD7 | FZD7 | Frizzled | F | Human | Cryo-EM | 9EPO | - | 1.9 | D | Inactive | 19 | 60 | - | - | - | - | - | - |
Apo (no ligand)
|
none | Apo (no ligand) | - | - | No | No | - | - | 2024-10-02 | Yes | |
| HCAR2 | HCA2 | Hydroxycarboxylic acid | A | Human | Cryo-EM | 9IQT | 9IQT_refined | 2.9 | R | Active | 100 | 80 | Gi/o | αi1 | - | 64 | - | scFv16 |
nicotinic acid
|
small-molecule | Agonist | butyric acid, β-D-hydroxybutyric acid | small-molecule | No | No | Liu Y, Zhou Z, Guan F, Han Z, Zhu C, Ye S, Yu X, Qiao A | 10.1016/J.JMB.2024.168795 | 2024-10-02 | Yes | |
| P2RY1 | P2Y1 | P2Y | A | Human | Cryo-EM | 8WJX | - | 3.2 | R | Active | 100 | 80 | Gs | αs | - | 61 | BRIL | Nanobody-35 |
ADP
|
small-molecule | Agonist | ADP, ATP | small-molecule | No | No | - | - | 2024-10-02 | Yes | |
| MC4R | MC4 | Melanocortin | A | Human | Cryo-EM | 8QJ2 | 8QJ2_refined | 3.4 | A | Active | 100 | 74 | Gs | αs | - | 56 | - | Nanobody-35 |
pN162
|
protein | Apo (no ligand) | γ-MSH, α-MSH, β-MSH, ACTH, agouti-related protein | peptide | No | No | - | - | 2024-09-25 | Yes | |
| PRLHR | PrRP | Prolactin-releasing peptide | A | Human | Cryo-EM | 8ZPS | 8ZPS_refined | 3.0 | R | Active | 100 | 78 | Gi/o | αi1 | - | 57 | - | scFv16 |
Prolactin-releasing peptide PrRP20
|
peptide | Agonist | PrRP-20, PTHrP, PrRP-31, neuropeptide Y | peptide | No | No | Li Y, Yuan Q, He X, Zhang Y, You C, Wu C, Li J, Xu HE, Zhao LH | 10.1038/S41421-024-00724-6 | 2024-09-25 | Yes | |
| PRLHR | PrRP | Prolactin-releasing peptide | A | Human | Cryo-EM | 8ZPT | 8ZPT_refined | 3.0 | R | Active | 100 | 79 | Gq/11 | αq | - | 59 | - | scFv16 |
Prolactin-releasing peptide PrRP20
|
peptide | Agonist | PrRP-20, PTHrP, PrRP-31, neuropeptide Y | peptide | No | No | Li Y, Yuan Q, He X, Zhang Y, You C, Wu C, Li J, Xu HE, Zhao LH | 10.1038/S41421-024-00724-6 | 2024-09-25 | Yes | |
| DRD3 | D3 | Dopamine | A | Human | Cryo-EM | 9F34 | - | 3.1 | R | Active | 100 | 68 | Gi/o | αo | - | 61 | - | scFv16 |
CHEMBL4551160
|
small-molecule | Agonist | dopamine | small-molecule | No | No | - | - | 2024-09-18 | Yes | |
| DRD3 | D3 | Dopamine | A | Human | Cryo-EM | 9F33 | - | 3.1 | R | Active | 100 | 68 | Gi/o | αo | - | 61 | - | scFv16 |
CHEMBL4551160
|
small-molecule | Agonist | dopamine | small-molecule | No | No | - | - | 2024-09-18 | Yes | |
| GIPR | GIP | Glucagon | B1 | Human | Cryo-EM | 8YW4 | 8YW4_refined | 3.3 | R | Active | 100 | 63 | Gs | αs | - | 60 | - | Nanobody-35 |
Retatrutide
|
peptide | Agonist | gastric inhibitory polypeptide | peptide | No | No | Li W, Zhou Q, Cong Z, Yuan Q, Li W, Zhao F, Xu HE, Zhao LH, Yang D, Wang MW | 10.1038/S41421-024-00700-0 | 2024-09-18 | Yes | |
| GLP1R | GLP-1 | Glucagon | B1 | Human | Cryo-EM | 8YW3 | 8YW3_refined | 2.7 | R | Active | 100 | 83 | Gs | αs | - | 57 | - | Nanobody-35 |
Retatrutide
|
peptide | Agonist | glucagon-like peptide 1-(7-36) amide, glucagon, glucagon-like peptide 1-(7-37) | peptide | No | No | Li W, Zhou Q, Cong Z, Yuan Q, Li W, Zhao F, Xu HE, Zhao LH, Yang D, Wang MW | 10.1038/S41421-024-00700-0 | 2024-09-18 | Yes | |
| GP179 | GPR179 | C Orphans | C | Human | Cryo-EM | 8IRJ | - | 3.5 | A | Inactive | - | 22 | - | - | - | - | - | - |
Apo (no ligand)
|
none | Apo (no ligand) | - | - | No | No | - | - | 2024-09-18 | Yes | |
| PAR1 | PAR1 | Proteinase-activated | A | Human | Cryo-EM | 8XOR | 8XOR_refined | 3.0 | R | Active | 100 | 70 | Gq/11 | αq | - | 60 | - | scFv16 |
Tethered agonist
|
peptide | Agonist | thrombin | peptide | No | No | - | - | 2024-09-18 | Yes | |
| PAR1 | PAR1 | Proteinase-activated | A | Human | Cryo-EM | 8XOS | - | 3.2 | R | Active | 100 | 68 | Gi/o | αi1 | - | 61 | - | scFv16 |
Tethered agonist
|
peptide | Agonist | thrombin | peptide | No | No | - | - | 2024-09-18 | Yes | |
| ADA2A | α2A | Adrenoceptors | A | Human | Cryo-EM | 9CBM | - | 3.2 | R | Active | 100 | 55 | Gi/o | αi1 | - | 60 | T4-Lysozyme | - |
dexmedetomidine
|
small-molecule | Agonist | (-)-adrenaline, (-)-noradrenaline | small-molecule | No | No | Lou JS, Su M, Wang J, Do HN, Miao Y, Huang XY | 10.1038/S12276-024-01296-X | 2024-09-11 | Yes | |
| ADA2A | α2A | Adrenoceptors | A | Human | Cryo-EM | 9CBL | - | 2.8 | R | Active | 100 | 55 | Gi/o | αi1 | - | 60 | T4-Lysozyme | - |
(-)-adrenaline
|
small-molecule | Agonist | (-)-adrenaline, (-)-noradrenaline | small-molecule | No | No | Lou JS, Su M, Wang J, Do HN, Miao Y, Huang XY | 10.1038/S12276-024-01296-X | 2024-09-11 | Yes | |
| BRS3 | BB3 | Bombesin | A | Human | Cryo-EM | 8Y53 | 8Y53_refined | 2.9 | R | Active | 100 | 75 | Gq/11 | αq | - | 60 | - | scFv16 Nanobody-35 |
MK-5046
|
small-molecule | Agonist | - | - | No | No | - | - | 2024-09-11 | Yes | |
| BRS3 | BB3 | Bombesin | A | Human | Cryo-EM | 8Y52 | 8Y52_refined | 2.9 | R | Active | 100 | 75 | Gq/11 | αq | - | 60 | - | - |
Bombesin
|
peptide | Agonist | - | - | No | No | Li C, Xu Y, Su W, He X, Li J, Li X, Xu HE, Yin W | 10.1016/J.CELREP.2024.114511 | 2024-09-11 | Yes | |
| CCR6 | CCR6 | Chemokine | A | Human | Cryo-EM | 9D3G | - | 3.3 | A | Inactive | 5 | 72 | - | - | - | - | BRIL | Fab heavy chain Fab light chain anti-BRIL Fab Nanobody |
1-(4-chlorophenyl)-N-[[(2R)-4-(2,3-dihydro-1H-inden-2-yl)-5-oxomorpholin-2-yl]methyl]cyclopropane-1-carboxamide
4-[[3,4-Dioxo-2-[[(1R)-1-(4-propan-2-ylfuran-2-yl)propyl]amino]cyclobuten-1-yl]amino]-3-hydroxy-N,N-dimethylpyridine-2-carboxamide |
small-molecule small-molecule |
Antagonist NAM |
CCL20, beta-defensin 4A | peptide | No | No | - | - | 2024-09-11 | Yes | |
| CCR6 | CCR6 | Chemokine | A | Human | Cryo-EM | 9D3E | - | 3.0 | A | Inactive | 5 | 66 | - | - | - | - | BRIL | anti-BRIL Fab heavy chain anti-BRIL Fab Nanobody anti-BRIL Fab light chain |
4-[[3,4-Dioxo-2-[[(1R)-1-(4-propan-2-ylfuran-2-yl)propyl]amino]cyclobuten-1-yl]amino]-3-hydroxy-N,N-dimethylpyridine-2-carboxamide
OXM2 |
small-molecule small-molecule |
Allosteric antagonist Antagonist |
CCL20, beta-defensin 4A | peptide | No | No | - | - | 2024-09-11 | Yes | |
| FZD4 | FZD4 | Frizzled | F | Human | Cryo-EM | 8WMA | - | 3.5 | A | Active | 78 | 60 | - | - | - | - | - | - |
Apo (no ligand)
|
none | Apo (no ligand) | - | - | No | No | Qian Y, Ma Z, Xu Z, Duan Y, Xiong Y, Xia R, Zhu X, Zhang Z, Tian X, Yin H, Liu J, Song J, Lu Y, Zhang A, Guo C, Jin L, Kim WJ, Ke J, Xu F, Huang Z, He Y | 10.1038/S41467-024-52174-Z | 2024-09-11 | Yes | |
| FZD4 | FZD4 | Frizzled | F | Human | Cryo-EM | 8WM9 | - | 3.5 | A | Active | 78 | 60 | - | - | - | - | - | - |
Apo (no ligand)
|
none | Apo (no ligand) | - | - | No | No | Qian Y, Ma Z, Xu Z, Duan Y, Xiong Y, Xia R, Zhu X, Zhang Z, Tian X, Yin H, Liu J, Song J, Lu Y, Zhang A, Guo C, Jin L, Kim WJ, Ke J, Xu F, Huang Z, He Y | 10.1038/S41467-024-52174-Z | 2024-09-11 | Yes | |
| GPC5D | GPRC5D | C Orphans | C | Human | Cryo-EM | 9IMA | - | 2.7 | A | Inactive | - | 72 | - | - | - | - | - | - |
Talquetamab Fab light chain
Talquetamab Fab heavy chain |
protein protein |
Antagonist | - | - | No | No | Jeong J, Park J, Young Mo G, Shin J, Cho Y | 10.1016/J.JMB.2024.168748 | 2024-09-11 | Yes | |
| OPRM | μ | Opioid | A | Mouse | Cryo-EM | 9BQJ | - | 3.3 | D | Active | 100 | 71 | Gi/o | αi1 | - | 61 | - | scFv16 |
N-[[3-(hydroxymethyl)phenyl]methyl]-N-[1-(2-phenylethyl)piperidin-4-yl]propanamide
|
small-molecule | Agonist | - | - | No | No | - | - | 2024-09-11 | Yes | |
| SUCR1 | succinate | Succinate | A | Human | Cryo-EM | 8WP1 | - | 3.2 | A | Active | 100 | 91 | Gi/o | αi1 | - | 64 | - | - |
cis-epoxysuccinic acid
|
small-molecule | Agonist | succinic acid | small-molecule | No | No | Liu A, Liu Y, Zhang W, Ye RD | 10.1016/J.CELREP.2024.114381 | 2024-09-11 | Yes | |
| SUCR1 | succinate | Succinate | A | Human | Cryo-EM | 8WOG | - | 3.0 | A | Active | 100 | 93 | Gi/o | αi1 | - | 64 | - | - |
succinic acid
|
small-molecule | Agonist | succinic acid | small-molecule | No | No | Liu A, Liu Y, Zhang W, Ye RD | 10.1016/J.CELREP.2024.114381 | 2024-09-11 | Yes | |
| DRD1 | D1 | Dopamine | A | Human | Cryo-EM | 8JXR | - | 3.6 | A | Active | 99 | 61 | - | - | - | - | - | Nanobody-3 Fab 8D3 heavy chain Fab 8D3 light chain |
Lysergide
|
small-molecule | Agonist | noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, dopamine, 5-hydroxytryptamine | small-molecule | No | No | Fan L, Zhuang Y, Wu H, Li H, Xu Y, Wang Y, He L, Wang S, Chen Z, Cheng J, Xu HE, Wang S | 10.1016/J.NEURON.2024.07.003 | 2024-09-04 | Yes | |
| DRD1 | D1 | Dopamine | A | Human | Cryo-EM | 8JXS | - | 3.0 | A | Active | 99 | 61 | - | - | - | - | - | Nanobody-3 Fab 8D3 heavy chain Fab 8D3 light chain |
CHEMBL4277264
|
small-molecule | Agonist | noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, dopamine, 5-hydroxytryptamine | small-molecule | No | No | Fan L, Zhuang Y, Wu H, Li H, Xu Y, Wang Y, He L, Wang S, Chen Z, Cheng J, Xu HE, Wang S | 10.1016/J.NEURON.2024.07.003 | 2024-09-04 | Yes | |
| FZD3 | FZD3 | Frizzled | F | Human | Cryo-EM | 8QW4 | - | 2.9 | A | Active | 99 | 48 | - | - | - | - | - | Nanobody-9 |
Apo (no ligand)
|
none | Apo (no ligand) | - | - | No | No | Hillier J, Zhao Y, Carrique L, Malinauskas T, Ruza RR, Chang TH, Yi G, Duyvesteyn HME, Yu J, Lu W, Pardon E, Steyaert J, Zhu Y, Ni T, Jones EY | 10.1038/S41467-024-51451-1 | 2024-09-04 | Yes | |
| 5HT2A | 5-HT2A | 5-Hydroxytryptamine | A | Human | X-ray | 8ZMG | - | 3.4 | A | Inactive | 1 | 59 | - | - | - | - | BRIL | - |
pimavanserin
|
small-molecule | Inverse agonist | tryptamine, 5-hydroxytryptamine | small-molecule | No | No | - | - | 2024-08-28 | Yes | |
| 5HT2C | 5-HT2C | 5-Hydroxytryptamine | A | Human | X-ray | 8ZMF | - | 3.6 | A | Inactive | 1 | 62 | - | - | - | - | BRIL | - |
1-[(4-Fluorophenyl)methyl]-1-(5-methyl-5-azaspiro[2.5]octan-8-yl)-3-[[4-(2-methylpropoxy)phenyl]methyl]urea
|
small-molecule | Inverse agonist | 5-hydroxytryptamine | small-molecule | No | No | - | - | 2024-08-28 | Yes | |
| EDNRA | ETA | Endothelin | A | Human | Cryo-EM | 8XVL | - | 3.2 | R | Inactive | 9 | 66 | - | - | - | - | BRIL | Fab heavy chain Fab light chain anti-Fab Nanobody |
zibotentan
|
small-molecule | Antagonist | endothelin-2, endothelin-3, endothelin-1 | peptide | No | No | - | - | 2024-08-28 | Yes | |
| EDNRA | ETA | Endothelin | A | Human | Cryo-EM | 8XVK | - | 3.2 | R | Inactive | 9 | 67 | - | - | - | - | BRIL | Fab heavy chain Fab light chain anti-Fab Nanobody |
ambrisentan
|
small-molecule | Antagonist | endothelin-2, endothelin-3, endothelin-1 | peptide | No | No | - | - | 2024-08-28 | Yes | |
| EDNRA | ETA | Endothelin | A | Human | Cryo-EM | 8XVJ | - | 3.3 | R | Inactive | 9 | 68 | - | - | - | - | BRIL | Fab heavy chain Fab light chain anti-Fab Nanobody |
macitentan
|
small-molecule | Antagonist | endothelin-2, endothelin-3, endothelin-1 | peptide | No | No | - | - | 2024-08-28 | Yes | |
| EDNRA | ETA | Endothelin | A | Human | Cryo-EM | 8XVI | 8XVI_refined | 3.3 | R | Active | 100 | 72 | Gs | αs | - | 59 | - | Nanobody-35 |
ENDOTHELIN
|
protein | Agonist | endothelin-2, endothelin-3, endothelin-1 | peptide | No | No | Hou J, Liu S, Zhang X, Tu G, Wu L, Zhang Y, Yang H, Li X, Liu J, Jiang L, Tan Q, Bai F, Liu Z, Miao C, Hua T, Luo Z | 10.1038/S41421-024-00705-9 | 2024-08-28 | Yes | |
| EDNRB | ETB | Endothelin | A | Human | Cryo-EM | 8XVE | 8XVE_refined | 3.0 | R | Active | 100 | 70 | Gs | αs | - | 59 | - | Nanobody-35 |
BQ3020
|
peptide | Agonist | endothelin-2, endothelin-3, endothelin-1 | peptide | No | No | Hou J, Liu S, Zhang X, Tu G, Wu L, Zhang Y, Yang H, Li X, Liu J, Jiang L, Tan Q, Bai F, Liu Z, Miao C, Hua T, Luo Z | 10.1038/S41421-024-00705-9 | 2024-08-28 | Yes | |
| EDNRB | ETB | Endothelin | A | Human | Cryo-EM | 8XVH | 8XVH_refined | 3.3 | R | Active | 100 | 69 | Gs | αs | - | 59 | - | Nanobody-35 |
ENDOTHELIN
|
protein | Agonist | endothelin-2, endothelin-3, endothelin-1 | peptide | No | No | Hou J, Liu S, Zhang X, Tu G, Wu L, Zhang Y, Yang H, Li X, Liu J, Jiang L, Tan Q, Bai F, Liu Z, Miao C, Hua T, Luo Z | 10.1038/S41421-024-00705-9 | 2024-08-28 | Yes | |
| ADRB3 | β3 | Adrenoceptors | A | Human | Cryo-EM | 9IJD | - | 2.8 | R | Active | 100 | 62 | Gs | αs | - | 57 | - | Camelid antibody VHH fragment |
Carazolol
|
small-molecule | Inverse agonist | (-)-adrenaline, (+)-adrenaline, (-)-noradrenaline, (±)-adrenaline | small-molecule | No | No | Zheng S, Zhang S, Dai S, Chen K, Gao K, Sun X, Lin B, Liu X | 10.1002/CPLU.202400288 | 2024-08-21 | Yes | |
| ADRB3 | β3 | Adrenoceptors | A | Human | Cryo-EM | 9IJE | 9IJE_refined | 2.3 | R | Active | 100 | 62 | Gs | αs | - | 57 | - | scFv16 Camelid antibody VHH fragment |
(-)-adrenaline
|
small-molecule | Agonist | (-)-adrenaline, (+)-adrenaline, (-)-noradrenaline, (±)-adrenaline | small-molecule | No | No | Zheng S, Zhang S, Dai S, Chen K, Gao K, Sun X, Lin B, Liu X | 10.1002/CPLU.202400288 | 2024-08-21 | Yes | |
| CML2 | chemerin 2 | Chemerin receptor | A | Human | Cryo-EM | 8JJP | - | 2.9 | A | Active | 100 | 82 | Gi/o | αi1 | - | 66 | - | scFv16 |
chemerin C-terminal peptide
|
peptide | Agonist | chemerin | peptide | No | No | - | - | 2024-08-21 | Yes | |
| CML2 | chemerin 2 | Chemerin receptor | A | Human | Cryo-EM | 8XGM | - | 3.3 | A | Active | 100 | 86 | Gi/o | αi1 | - | 66 | - | scFv16 |
Retinoic acid receptor responder protein 2
|
protein | Agonist | chemerin | peptide | No | No | - | - | 2024-08-21 | Yes | |
| DRD2 | D2 | Dopamine | A | Human | Cryo-EM | 8U02 | 8U02_refined | 3.3 | R | Active | 100 | 61 | Gi/o | αo | - | 97 | - | - |
dopamine
|
small-molecule | Agonist | dopamine | small-molecule | No | No | Knight KM, Krumm BE, Kapolka NJ, Ludlam WG, Cui M, Mani S, Prytkova I, Obarow EG, Lefevre TJ, Wei W, Ma N, Huang XP, Fay JF, Vaidehi N, Smrcka AV, Slesinger PA, Logothetis DE, Martemyanov KA, Roth BL, Dohlman HG | 10.1038/S41467-024-50964-Z | 2024-08-21 | Yes | |
| DRD2 | D2 | Dopamine | A | Human | Cryo-EM | 8TZQ | 8TZQ_refined | 3.2 | R | Active | 100 | 61 | Gi/o | αo | - | 62 | - | scFv16 |
dopamine
|
small-molecule | Agonist | dopamine | small-molecule | No | No | Knight KM, Krumm BE, Kapolka NJ, Ludlam WG, Cui M, Mani S, Prytkova I, Obarow EG, Lefevre TJ, Wei W, Ma N, Huang XP, Fay JF, Vaidehi N, Smrcka AV, Slesinger PA, Logothetis DE, Martemyanov KA, Roth BL, Dohlman HG | 10.1038/S41467-024-50964-Z | 2024-08-21 | Yes | |
| E7FEL0 | GPR4 | A orphans | A | Zebrafish | Cryo-EM | 8ZFJ | - | 3.1 | R | Active | 100 | 72 | Gs | αs | - | 60 | BRIL | scFv16 |
Apo (no ligand)
|
none | Apo (no ligand) | - | - | No | No | - | - | 2024-08-07 | Yes | |
| GLR | glucagon | Glucagon | B1 | Human | Cryo-EM | 8YW5 | 8YW5_refined | 2.8 | R | Active | 100 | 79 | Gs | αs | - | 57 | - | Nanobody-35 |
Retatrutide
|
peptide | Agonist | glucagon | peptide | No | No | Li W, Zhou Q, Cong Z, Yuan Q, Li W, Zhao F, Xu HE, Zhao LH, Yang D, Wang MW | 10.1038/S41421-024-00700-0 | 2024-08-07 | Yes | |
| MC4R | MC4 | Melanocortin | A | Human | X-ray | 8WKY | - | 2.9 | A | Intermediate | 41 | 79 | - | - | - | - | GlgA glycogen synthase | - |
N-(2-aminoethyl)-5-(2-{[4-(morpholin-4-yl)pyridin-2-yl]amino}-1,3-thiazol-5-yl)pyridine-3-carboxamide
|
peptide | Antagonist | γ-MSH, α-MSH, β-MSH, ACTH, agouti-related protein | peptide | No | No | Gimenez LE, Martin C, Yu J, Hollanders C, Hernandez CC, Wu Y, Yao D, Han GW, Dahir NS, Wu L, Van der Poorten O, Lamouroux A, Mannes M, Zhao S, Tourwe D, Stevens RC, Cone RD, Ballet S | 10.1021/ACS.JMEDCHEM.3C01822 | 2024-08-07 | Yes | |
| MC4R | MC4 | Melanocortin | A | Human | X-ray | 8WKZ | - | 3.3 | A | Intermediate | 41 | 79 | - | - | - | - | GlgA glycogen synthase | - |
[N-(3-{bis[2-(pyridin-2-yl-kappaN)ethyl]amino-kappaN}propyl)-5-(2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide](azido)(hydroxy)copper
|
peptide | Antagonist | γ-MSH, α-MSH, β-MSH, ACTH, agouti-related protein | peptide | No | No | Gimenez LE, Martin C, Yu J, Hollanders C, Hernandez CC, Wu Y, Yao D, Han GW, Dahir NS, Wu L, Van der Poorten O, Lamouroux A, Mannes M, Zhao S, Tourwe D, Stevens RC, Cone RD, Ballet S | 10.1021/ACS.JMEDCHEM.3C01822 | 2024-08-07 | Yes | |
| ACKR1 | ACKR1 | Chemokine | A | Human | Cryo-EM | 8JPS | - | 3.7 | A | Intermediate | 46 | 76 | - | - | - | - | - | - |
C-C motif chemokine 7
|
peptide | Agonist | CXCL11, CCL11, CXCL6, CCL2, CCL7, CXCL8, CCL5, CCL14, CCL17, CXCL5 | peptide | No | No | Saha S, Khanppnavar B, Maharana J, Kim H, Carino CMC, Daly C, Houston S, Sharma S, Zaidi N, Dalal A, Mishra S, Ganguly M, Tiwari D, Kumari P, Jhingan GD, Yadav PN, Plouffe B, Inoue A, Chung KY, Banerjee R, Korkhov VM, Shukla AK | 10.1016/J.CELL.2024.07.005 | 2024-07-31 | Yes | |
| GRM3 | mGlu3 | Metabotropic glutamate | C | Human | Cryo-EM | 8TQB | - | 3.3 | A | Active | - | 85 | - | - | - | - | - | - |
LY379268
|
small-molecule | Agonist | NAAG, L-glutamic acid | small-molecule | No | No | Strauss A, Gonzalez-Hernandez AJ, Lee J, Abreu N, Selvakumar P, Salas-Estrada L, Kristt M, Marx DC, Gilliland K, Melancon BJ, Filizola M, Meyerson J, Levitz J | 10.1101/2023.08.13.552748 | 2024-07-31 | Yes | |
| GRM3 | mGlu3 | Metabotropic glutamate | C | Human | Cryo-EM | 8TR2 | - | 3.5 | A | Active | - | 85 | - | - | - | - | - | - |
(1S,4R,5R,6S)-4-amino-2-oxabicyclo[3.1.0]hexane-4,6-dicarboxylic acid
|
small-molecule | Agonist | NAAG, L-glutamic acid | small-molecule | No | No | Strauss A, Gonzalez-Hernandez AJ, Lee J, Abreu N, Selvakumar P, Salas-Estrada L, Kristt M, Marx DC, Gilliland K, Melancon BJ, Filizola M, Meyerson J, Levitz J | 10.1101/2023.08.13.552748 | 2024-07-31 | Yes | |
| GRM3 | mGlu3 | Metabotropic glutamate | C | Human | Cryo-EM | 8TRD | - | 3.4 | A | Inactive | - | 84 | - | - | - | - | - | - |
LY341495
|
small-molecule | Antagonist | NAAG, L-glutamic acid | small-molecule | No | No | Strauss A, Gonzalez-Hernandez AJ, Lee J, Abreu N, Selvakumar P, Salas-Estrada L, Kristt M, Arefin A, Huynh K, Marx DC, Gilliland K, Melancon BJ, Filizola M, Meyerson J, Levitz J | 10.1038/S41467-024-50548-X | 2024-07-31 | Yes | |
| GRM3 | mGlu3 | Metabotropic glutamate | C | Human | Cryo-EM | 8TRC | - | 3.3 | A | Inactive | - | 84 | - | - | - | - | - | - |
LY341495
|
small-molecule | Antagonist | NAAG, L-glutamic acid | small-molecule | No | No | Strauss A, Gonzalez-Hernandez AJ, Lee J, Abreu N, Selvakumar P, Salas-Estrada L, Kristt M, Marx DC, Gilliland K, Melancon BJ, Filizola M, Meyerson J, Levitz J | 10.1101/2023.08.13.552748 | 2024-07-31 | Yes | |
| GRM3 | mGlu3 | Metabotropic glutamate | C | Human | Cryo-EM | 8TR0 | - | 3.2 | A | Inactive | - | 85 | - | - | - | - | - | - |
LY341495
|
small-molecule | Antagonist | NAAG, L-glutamic acid | small-molecule | No | No | Strauss A, Gonzalez-Hernandez AJ, Lee J, Abreu N, Selvakumar P, Salas-Estrada L, Kristt M, Marx DC, Gilliland K, Melancon BJ, Filizola M, Meyerson J, Levitz J | 10.1101/2023.08.13.552748 | 2024-07-31 | Yes | |
| NPY1R | Y1 | Neuropeptide Y | A | Human | Cryo-EM | 8K6O | 8K6O_refined | 3.3 | D | Active | 100 | 78 | Gi/o | αi2 | - | 63 | - | scFv16 |
neuropeptide Y
|
peptide | Agonist | peptide YY, pancreatic polypeptide, neuropeptide Y | peptide | No | No | - | - | 2024-07-31 | Yes | |
| NPY1R | Y1 | Neuropeptide Y | A | Human | Cryo-EM | 8K6M | 8K6M_refined | 3.3 | D | Active | 100 | 78 | Gi/o | αi2 | - | 63 | - | scFv16 |
neuropeptide Y
|
peptide | Agonist | peptide YY, pancreatic polypeptide, neuropeptide Y | peptide | No | No | - | - | 2024-07-31 | Yes | |
| NPY2R | Y2 | Neuropeptide Y | A | Human | Cryo-EM | 8K6N | 8K6N_refined | 3.2 | E | Active | 100 | 79 | Gi/o | αi2 | - | 63 | - | scFv16 |
neuropeptide Y
|
peptide | Agonist | PYY-(3-36), peptide YY, neuropeptide Y-(3-36), pancreatic polypeptide, neuropeptide Y | peptide | No | No | - | - | 2024-07-31 | Yes | |
| P2Y10 | P2RY10 | A orphans | A | Human | Cryo-EM | 8KGG | - | 3.1 | R | Active | 100 | 86 | G12/13 | α13 | - | 56 | - | scFv16 |
(2~{S})-2-$l^{4}-azanyl-3-[[(2~{R})-3-octadecanoyloxy-2-oxidanyl-propoxy]-oxidanyl-oxidanylidene-$l^{6}-phosphanyl]oxy-propanoic acid
|
lipid | Agonist | LYSOPHOSPHATIDIC ACID, LPA, sphingosine 1-phosphate, 1-O-Oleoyl-D-glycerol 3-phosphoric acid | small-molecule | No | No | Yin H, Kamakura N, Qian Y, Tatsumi M, Ikuta T, Liang J, Xu Z, Xia R, Zhang A, Guo C, Inoue A, He Y | 10.1016/J.CHEMBIOL.2024.08.005 | 2024-07-31 | Yes | |
| Q76SF8 | ORF74 | Unclassified | A | HHV-8 | Cryo-EM | 8K4P | - | 2.8 | A | Active | 100 | 86 | Gi/o | αi1 | - | 66 | - | - |
Apo (no ligand)
|
none | Apo (no ligand) | - | - | No | No | - | - | 2024-07-24 | Yes | |
| Q76SF8 | ORF74 | Unclassified | A | HHV-8 | Cryo-EM | 8K4O | - | 3.0 | E | Active | 100 | 97 | Gi/o | αi1 | - | 65 | - | - |
Growth-regulated alpha protein
|
protein | Agonist | - | - | No | No | - | - | 2024-07-24 | Yes | |
| T2R14 | TAS2R14 | Taste 2 | T2 | Human | Cryo-EM | 9IIX | - | 2.9 | R | Active | 100 | 90 | Gi/o | αgust | - | 64 | - | - |
compound 28.1 [PMID: 36847646]
compound 28.1 [PMID: 36847646] |
small-molecule small-molecule |
Agonist Allosteric agonist |
- | - | No | No | - | - | 2024-07-24 | Yes | |
| T2R14 | TAS2R14 | Taste 2 | T2 | Human | Cryo-EM | 9IJA | - | 3.1 | R | Inactive | 0 | 90 | - | - | - | - | - | - |
Cholesterol
compound 28.1 [PMID: 36847646] |
small-molecule small-molecule |
Agonist Allosteric agonist |
- | - | No | No | - | - | 2024-07-24 | Yes | |
| T2R14 | TAS2R14 | Taste 2 | T2 | Human | Cryo-EM | 9IIW | - | 3.2 | R | Inactive | 0 | 90 | - | - | - | - | - | - |
compound 28.1 [PMID: 36847646]
compound 28.1 [PMID: 36847646] |
small-molecule small-molecule |
Agonist Allosteric agonist |
- | - | No | No | - | - | 2024-07-24 | Yes | |
| T2R14 | TAS2R14 | Taste 2 | T2 | Human | Cryo-EM | 9IJ9 | - | 2.7 | R | Active | 100 | 90 | Gi/o | αi1 | - | 62 | - | - |
Cholesterol
compound 28.1 [PMID: 36847646] |
small-molecule small-molecule |
Agonist Allosteric agonist |
- | - | No | No | - | - | 2024-07-24 | Yes | |
| TAAR1 | TA1 | Trace amine | A | Human | Cryo-EM | 8ZSS | - | 3.1 | R | Active | 100 | 83 | Gs | αs | - | 58 | BRIL | Nanobody-35 |
RO5256390
|
small-molecule | Agonist | tyramine, (+)-Octopamine, octopamine, β-phenylethylamine, CHEMBL1160703, 3-iodothyronamine, dopamine | small-molecule | No | No | - | - | 2024-07-24 | Yes | |
| TAAR1 | TA1 | Trace amine | A | Human | Cryo-EM | 8ZSJ | - | 2.8 | R | Active | 100 | 83 | Gs | αs | - | 58 | BRIL | Nanobody-35 |
Apo (no ligand)
|
none | Apo (no ligand) | tyramine, (+)-Octopamine, octopamine, β-phenylethylamine, CHEMBL1160703, 3-iodothyronamine, dopamine | small-molecule | No | No | Jiang K, Zheng Y, Zeng L, Wang L, Li F, Pu J, Lu Y, Zhao S, Xu F | 10.1016/J.CELREP.2024.114505 | 2024-07-24 | Yes | |
| TAAR1 | TA1 | Trace amine | A | Human | Cryo-EM | 8ZSP | - | 3.1 | R | Active | 100 | 83 | Gs | αs | - | 58 | BRIL | Nanobody-35 |
Lysergide
|
small-molecule | Agonist | tyramine, (+)-Octopamine, octopamine, β-phenylethylamine, CHEMBL1160703, 3-iodothyronamine, dopamine | small-molecule | No | No | Jiang K, Zheng Y, Zeng L, Wang L, Li F, Pu J, Lu Y, Zhao S, Xu F | 10.1016/J.CELREP.2024.114505 | 2024-07-24 | Yes | |
| TAAR1 | TA1 | Trace amine | A | Mouse | Cryo-EM | 8ZSV | - | 3.0 | R | Active | 100 | 85 | Gs | αs | - | 58 | BRIL | Nanobody-35 |
RO5256390
|
small-molecule | Agonist | tyramine, β-phenylethylamine, 3-iodothyronamine | small-molecule | No | No | - | - | 2024-07-24 | Yes | |
| ADRB2 | β2 | Adrenoceptors | A | Human | X-ray | 8W1V | - | 3.0 | A | Inactive | 0 | 68 | - | - | - | - | T4-Lysozyme | Nanobody-60 |
(2S)-1-[(3-{1-[4-(4-{(2S)-2-hydroxy-3-[(propan-2-yl)amino]propoxy}phenyl)butyl]-1H-1,2,3-triazol-4-yl}propyl)amino]-3-(2-propylphenoxy)propan-2-ol
|
small-molecule | Antagonist | Zn2+, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline | small-molecule | No | No | - | - | 2024-07-17 | Yes | |
| CXCR4 | CXCR4 | Chemokine | A | Human | Cryo-EM | 8K3Z | - | 2.8 | A | Active | 100 | 84 | Gi/o | αi1 | - | 66 | - | scFv16 |
Stromal cell-derived factor 1
|
peptide | Agonist | CXCL12, CXCL12β, CXCL12α, CXCL12φ, CXCL12γ, CXCL12δ, CXCL12ε | peptide | No | No | - | - | 2024-07-17 | Yes | |
| OPRM | μ | Opioid | A | Mouse | Cryo-EM | 9BJK | - | 3.3 | R | Inactive | 8 | 72 | - | - | - | - | - | Nanobody-6 |
naloxone
(2S)-3-(3-methoxy-4-methylphenyl)-N-methyl-2-[[2-[1-(5-phenylmethoxypyridin-3-yl)naphthalen-2-yl]sulfanylacetyl]amino]propanamide |
small-molecule small-molecule |
Antagonist NAM |
- | - | No | No | - | - | 2024-07-17 | Yes | |
| GPR15 | GPR15 | A orphans | A | Human | Cryo-EM | 8ZQE | 8ZQE_refined | 2.9 | R | Active | 100 | 77 | Gi/o | αi1 | - | 62 | - | scFv16 |
GPR15LG
|
peptide | Agonist | - | - | No | No | Zhang Z, Zheng Y, Xu L, Yue Y, Xu K, Li F, Xu F | 10.1038/S41421-024-00698-5 | 2024-07-10 | Yes | |
| SSR5 | SST5 | Somatostatin | A | Human | Cryo-EM | 8ZBE | 8ZBE_refined | 3.2 | A | Active | 100 | 72 | Gi/o | αi1 | - | 60 | - | scFv16 |
Octreotide
|
peptide | Agonist | CST-17, SRIF-14, cortistatin-14, SRIF-28 | peptide | No | No | Li YG, Meng XY, Yang X, Ling SL, Shi P, Tian CL, Yang F | 10.1038/S41401-024-01314-8 | 2024-07-10 | Yes | |
| SSR5 | SST5 | Somatostatin | A | Human | Cryo-EM | 8ZCJ | 8ZCJ_refined | 3.1 | G | Active | 100 | 76 | Gi/o | αi1 | - | 63 | - | scFv16 |
004-DTR-LYS-TYR-PHA-HYP
|
peptide | Agonist | CST-17, SRIF-14, cortistatin-14, SRIF-28 | peptide | No | No | Li YG, Meng XY, Yang X, Ling SL, Shi P, Tian CL, Yang F | 10.1038/S41401-024-01314-8 | 2024-07-10 | Yes | |
| T2R14 | TAS2R14 | Taste 2 | T2 | Human | Cryo-EM | 8XQP | - | 3.3 | R | Active | 100 | 90 | Gi/o | αgust | - | 63 | - | scFv16 |
aristolochic acid
|
small-molecule | Agonist | - | - | No | No | Hu X, Ao W, Gao M, Wu L, Pei Y, Liu S, Wu Y, Zhao F, Sun Q, Liu J, Jiang L, Wang X, Li Y, Tan Q, Cheng J, Yang F, Yang C, Sun J, Hua T, Liu ZJ | 10.1038/S41586-024-07569-9 | 2024-07-10 | Yes | |
| T2R14 | TAS2R14 | Taste 2 | T2 | Human | Cryo-EM | 8XQN | - | 3.1 | R | Active | 100 | 90 | Gi/o | αi1 | - | 64 | - | scFv16 |
aristolochic acid
|
small-molecule | Agonist | - | - | No | No | Hu X, Ao W, Gao M, Wu L, Pei Y, Liu S, Wu Y, Zhao F, Sun Q, Liu J, Jiang L, Wang X, Li Y, Tan Q, Cheng J, Yang F, Yang C, Sun J, Hua T, Liu ZJ | 10.1038/S41586-024-07569-9 | 2024-07-10 | Yes | |
| T2R14 | TAS2R14 | Taste 2 | T2 | Human | Cryo-EM | 8YKY | - | 3.0 | R | Active | 100 | 85 | Gi/o | αgust | - | 61 | - | scFv16 |
compound 28.1 [PMID: 36847646]
|
small-molecule | Agonist | - | - | No | No | - | - | 2024-07-10 | Yes | |
| T2R14 | TAS2R14 | Taste 2 | T2 | Human | Cryo-EM | 8XQS | - | 3.3 | R | Active | 100 | 85 | Gi/o | αi1 | - | 64 | - | scFv16 |
flufenamic acid
|
small-molecule | Agonist | - | - | No | No | Hu X, Ao W, Gao M, Wu L, Pei Y, Liu S, Wu Y, Zhao F, Sun Q, Liu J, Jiang L, Wang X, Li Y, Tan Q, Cheng J, Yang F, Yang C, Sun J, Hua T, Liu ZJ | 10.1038/S41586-024-07569-9 | 2024-07-10 | Yes | |
| T2R14 | TAS2R14 | Taste 2 | T2 | Human | Cryo-EM | 8XQL | - | 3.0 | R | Active | 100 | 90 | Gi/o | αgust | - | 63 | - | Nanobody-35 |
aristolochic acid
|
small-molecule | Agonist | - | - | No | No | Hu X, Ao W, Gao M, Wu L, Pei Y, Liu S, Wu Y, Zhao F, Sun Q, Liu J, Jiang L, Wang X, Li Y, Tan Q, Cheng J, Yang F, Yang C, Sun J, Hua T, Liu ZJ | 10.1038/S41586-024-07569-9 | 2024-07-10 | Yes | |
| T2R14 | TAS2R14 | Taste 2 | T2 | Human | Cryo-EM | 8XQT | - | 2.9 | R | Active | 100 | 86 | Gi/o | αi1 | - | 64 | - | scFv16 |
Cholesterol
|
small-molecule | Agonist | - | - | No | No | Hu X, Ao W, Gao M, Wu L, Pei Y, Liu S, Wu Y, Zhao F, Sun Q, Liu J, Jiang L, Wang X, Li Y, Tan Q, Cheng J, Yang F, Yang C, Sun J, Hua T, Liu ZJ | 10.1038/S41586-024-07569-9 | 2024-07-10 | Yes | |
| T2R14 | TAS2R14 | Taste 2 | T2 | Human | Cryo-EM | 8XQR | - | 3.2 | R | Active | 100 | 88 | Gi/o | αgust | - | 63 | - | Nanobody-35 |
flufenamic acid
|
small-molecule | Agonist | - | - | No | No | Hu X, Ao W, Gao M, Wu L, Pei Y, Liu S, Wu Y, Zhao F, Sun Q, Liu J, Jiang L, Wang X, Li Y, Tan Q, Cheng J, Yang F, Yang C, Sun J, Hua T, Liu ZJ | 10.1038/S41586-024-07569-9 | 2024-07-10 | Yes | |
| T2R14 | TAS2R14 | Taste 2 | T2 | Human | Cryo-EM | 8XQO | - | 2.8 | R | Active | 100 | 89 | Gi/o | αi1 | - | 64 | - | scFv16 |
aristolochic acid
|
small-molecule | Agonist | - | - | No | No | Hu X, Ao W, Gao M, Wu L, Pei Y, Liu S, Wu Y, Zhao F, Sun Q, Liu J, Jiang L, Wang X, Li Y, Tan Q, Cheng J, Yang F, Yang C, Sun J, Hua T, Liu ZJ | 10.1038/S41586-024-07569-9 | 2024-07-10 | Yes | |
| GPC5D | GPRC5D | C Orphans | C | Human | Cryo-EM | 8YZK | - | 3.4 | B | Inactive | - | 77 | - | - | - | - | BRIL | scFv |
Apo (no ligand)
|
none | Apo (no ligand) | - | - | No | No | Yan P, Lin X, Wu L, Xu L, Li F, Liu J, Xu F | 10.1038/S41467-024-49625-Y | 2024-07-03 | Yes | |
| KISSR | kisspeptin | Kisspeptin | A | Human | Cryo-EM | 8ZJE | - | 3.1 | R | Active | 100 | 70 | Gq/11 | αq | - | 63 | - | scFv16 |
ACY-DTY-HYP-ASN-THR-PHE-XZA-LEU-NMM-TRP-NH2
|
peptide | Agonist | kisspeptin-13, kisspeptin-54, kisspeptin-14, kisspeptin-52, kisspeptin-10 | peptide | No | No | - | - | 2024-07-03 | Yes | |
| KISSR | kisspeptin | Kisspeptin | A | Human | Cryo-EM | 8ZJD | - | 3.1 | R | Active | 100 | 72 | Gq/11 | αq | - | 63 | - | scFv16 |
Kisspeptin-10
|
peptide | Agonist | kisspeptin-13, kisspeptin-54, kisspeptin-14, kisspeptin-52, kisspeptin-10 | peptide | No | No | - | - | 2024-07-03 | Yes | |
| QRFPR | QRFP | Peptide P518 | A | Human | Cryo-EM | 8ZH8 | - | 3.2 | R | Active | 100 | 75 | Gq/11 | αq | - | 57 | - | scFv16 |
QRF-amide
|
peptide | Agonist | QRFP26 (26RFa), QRFP43, QRFP43 (43RFa) | peptide | No | No | Iwama A, Kise R, Akasaka H, Sano FK, Oshima HS, Inoue A, Shihoya W, Nureki O | 10.1038/S41467-024-49030-5 | 2024-07-03 | Yes | |
| SSR1 | SST1 | Somatostatin | A | Human | Cryo-EM | 8XIP | - | 3.3 | A | Active | 100 | 73 | Gi/o | αi1 | - | 62 | - | Nanobody-35 |
004-DTR-LYS-TY5-PHE-A1D5E
|
peptide | Agonist | CST-17, SRIF-14, cortistatin-14, SRIF-28 | peptide | No | No | - | - | 2024-07-03 | Yes | |
| SSR1 | SST1 | Somatostatin | A | Human | Cryo-EM | 8XIO | - | 2.7 | A | Active | 100 | 73 | Gi/o | αi1 | - | 62 | - | Nanobody-35 |
(2S)-N-[(4S)-6-amino-2,2,4-trimethylhexyl]-3-naphthalen-1-yl-2-[[2-phenylethyl(2-pyridin-2-ylethyl)carbamoyl]amino]propanamide
|
small-molecule | Agonist | CST-17, SRIF-14, cortistatin-14, SRIF-28 | peptide | No | No | - | - | 2024-07-03 | Yes | |
| SSR3 | SST3 | Somatostatin | A | Human | Cryo-EM | 8XIR | - | 2.5 | A | Active | 100 | 69 | Gi/o | αi1 | - | 62 | - | Nanobody-35 |
004-DTR-LYS-TY5-PHE-A1D5E
|
peptide | Agonist | CST-17, SRIF-14, cortistatin-14, SRIF-28 | peptide | No | No | - | - | 2024-07-03 | Yes | |
| SSR3 | SST3 | Somatostatin | A | Human | Cryo-EM | 8XIQ | - | 2.7 | A | Active | 100 | 69 | Gi/o | αi1 | - | 62 | - | Nanobody-35 |
NIT-FC0-NLE-A1D5B
|
peptide | Agonist | CST-17, SRIF-14, cortistatin-14, SRIF-28 | peptide | No | No | - | - | 2024-07-03 | Yes | |
| CNR1 | CB1 | Cannabinoid | A | Human | Cryo-EM | 9ERX | 9ERX_refined | 2.9 | R | Active | 100 | 62 | Gi/o | αi1 | - | 63 | - | scFv16 |
HU-210
|
small-molecule | Agonist | 2-arachidonoylglycerol, anandamide | small-molecule | No | No | - | - | 2024-06-26 | Yes | |
| AA2AR | A2A | Adenosine | A | Human | X-ray | 8RLN | - | 2.4 | A | Inactive | 1 | 72 | - | - | - | - | BRIL | - |
CHEMBL122622
|
small-molecule | Agonist (partial) | adenosine | small-molecule | No | No | - | - | 2024-06-19 | Yes | |
| GP119 | GPR119 | GPR18, GPR55 and GPR119 | A | Human | Cryo-EM | 8ZRK | - | 2.8 | R | Active | 100 | 81 | Gs | αs | - | 60 | - | Nanobody-35 |
GSK-1292263
|
small-molecule | Agonist | N-oleoylethanolamide, N-palmitoylethanolamine, SEA, anandamide | small-molecule | No | No | - | - | 2024-06-19 | Yes | |
| GP119 | GPR119 | GPR18, GPR55 and GPR119 | A | Human | Cryo-EM | 8ZR5 | - | 3.3 | C | Active | 100 | 85 | Gs | αs | - | 60 | - | Nanobody-35 |
DS-8500a
|
small-molecule | Agonist | N-oleoylethanolamide, N-palmitoylethanolamine, SEA, anandamide | small-molecule | No | No | - | - | 2024-06-19 | Yes | |
| MCHR1 | MCH1 | Melanin-concentrating hormone | A | Human | Cryo-EM | 8WSS | 8WSS_refined | 3.0 | R | Active | 100 | 67 | Gi/o | αi1 | - | 61 | - | scFv16 |
pro-MCH
|
peptide | Agonist | melanin-concentrating hormone | peptide | No | No | He Q, Yuan Q, Shan H, Wu C, Gu Y, Wu K, Hu W, Zhang Y, He X, Xu HE, Zhao LH | 10.1038/S41421-024-00679-8 | 2024-06-19 | Yes | |
| MCHR2 | MCH2 | Melanin-concentrating hormone | A | Human | Cryo-EM | 8WST | 8WST_refined | 2.4 | R | Active | 100 | 84 | Gq/11 | αq | - | 59 | - | Nanobody-35 |
pro-MCH
|
peptide | Agonist | melanin-concentrating hormone | peptide | No | No | He Q, Yuan Q, Shan H, Wu C, Gu Y, Wu K, Hu W, Zhang Y, He X, Xu HE, Zhao LH | 10.1038/S41421-024-00679-8 | 2024-06-19 | Yes | |
| QRFPR | QRFP | Peptide P518 | A | Human | Cryo-EM | 8WZ2 | 8WZ2_refined | 2.7 | R | Active | 100 | 75 | Gq/11 | αq | - | 60 | - | scFv16 |
Orexigenic neuropeptide QRFP
|
peptide | Agonist | QRFP26 (26RFa), QRFP43, QRFP43 (43RFa) | peptide | No | No | Jin S, Guo S, Xu Y, Li X, Wu C, He X, Pan B, Xin W, Zhang H, Hu W, Yin Y, Zhang T, Wu K, Yuan Q, Xu HE, Xie X, Jiang Y | 10.1038/S41421-024-00670-3 | 2024-06-19 | Yes | |
| SSR5 | SST5 | Somatostatin | A | Human | Cryo-EM | 8X8L | 8X8L_refined | 2.7 | R | Active | 100 | 75 | Gi/o | αi1 | - | 62 | - | scFv16 |
Cortistatin
|
peptide | Agonist | CST-17, SRIF-14, cortistatin-14, SRIF-28 | peptide | No | No | - | - | 2024-06-12 | Yes | |
| SSR5 | SST5 | Somatostatin | A | Human | Cryo-EM | 8X8N | 8X8N_refined | 2.9 | R | Active | 100 | 74 | Gi/o | αi1 | - | 62 | - | scFv16 |
Octreotide
|
peptide | Agonist | CST-17, SRIF-14, cortistatin-14, SRIF-28 | peptide | No | No | - | - | 2024-06-12 | Yes | |
| CNR1 | CB1 | Cannabinoid | A | Human | Cryo-EM | 8IKH | 8IKH_refined | 3.3 | R | Active | 100 | 56 | Gi/o | αi1 | - | 61 | - | scFv16 |
3-[(1R)-1-(2-methoxyphenyl)-2-nitro-ethyl]-2-phenyl-1H-indole
|
small-molecule | Agonist | 2-arachidonoylglycerol, anandamide | small-molecule | No | No | Shen S, Wu C, Lin G, Yang X, Zhou Y, Zhao C, Miao Z, Tian X, Wang K, Yang Z, Liu Z, Guo N, Li Y, Xia A, Zhou P, Liu J, Yan W, Ke B, Yang S, Shao Z | 10.1073/PNAS.2321532121 | 2024-06-05 | Yes | |
| CNR1 | CB1 | Cannabinoid | A | Human | Cryo-EM | 8IKG | 8IKG_refined | 3.4 | R | Active | 100 | 58 | Gi/o | αi1 | - | 61 | - | scFv16 |
3-[(1S)-1-(furan-2-yl)-2-nitro-ethyl]-2-phenyl-1H-indole
|
small-molecule | Agonist | 2-arachidonoylglycerol, anandamide | small-molecule | No | No | Shen S, Wu C, Lin G, Yang X, Zhou Y, Zhao C, Miao Z, Tian X, Wang K, Yang Z, Liu Z, Guo N, Li Y, Xia A, Zhou P, Liu J, Yan W, Ke B, Yang S, Shao Z | 10.1073/PNAS.2321532121 | 2024-06-05 | Yes | |
| HRH2 | H2 | Histamine | A | Human | Cryo-EM | 8YUT | - | 2.7 | R | Active | 100 | 82 | Gs | αs | - | 58 | - | Nanobody-35 |
amthamine
|
small-molecule | Agonist | histamine | small-molecule | No | No | - | - | 2024-06-05 | Yes | |
| HRH3 | H3 | Histamine | A | Human | Cryo-EM | 8YUV | - | 3.0 | R | Active | 100 | 65 | Gi/o | αi1 | - | 64 | - | - |
immepip
|
small-molecule | Agonist | histamine | small-molecule | No | No | - | - | 2024-06-05 | Yes | |
| HRH3 | H3 | Histamine | A | Human | Cryo-EM | 8YUU | - | 2.7 | R | Active | 100 | 65 | Gi/o | αi1 | - | 64 | - | scFv16 |
histamine
|
small-molecule | Agonist | histamine | small-molecule | No | No | Shen Q, Tang X, Wen X, Cheng S, Xiao P, Zang SK, Shen DD, Jiang L, Zheng Y, Zhang H, Xu H, Mao C, Zhang M, Hu W, Sun JP, Zhang Y, Chen Z | 10.1002/ADVS.202310120 | 2024-06-05 | Yes | |
| 5HT1A | 5-HT1A | 5-Hydroxytryptamine | A | Human | Cryo-EM | 8PKM | - | 2.9 | R | Active | 100 | 66 | Gi/o | αi1 | - | 61 | - | - |
BEFIRADOL
(2r)-1-(Heptadecanoyloxy)-3-{[(R)-Hydroxy{[(1r,2r,3r,4r,5s,6r)-2,3,5,6-Tetrahydroxy-4-(Phosphonooxy)cyclohexyl]oxy}phosphoryl]oxy}propan-2-Yl (5z,8z,11z,14z)-Icosa-5,8,11,14-Tetraenoate |
small-molecule small-molecule |
Agonist PAM |
5-hydroxytryptamine | small-molecule | No | No | - | - | 2024-05-29 | Yes | |
| 5HT1A | 5-HT1A | 5-Hydroxytryptamine | A | Human | Cryo-EM | 8PJK | - | 2.4 | R | Active | 100 | 68 | Gi/o | αi1 | - | 63 | - | - |
6-[3-[2-(2-methoxyphenoxy)ethylamino]propoxy]-4~{H}-1,4-benzoxazin-3-one
(2r)-1-(Heptadecanoyloxy)-3-{[(R)-Hydroxy{[(1r,2r,3r,4r,5s,6r)-2,3,5,6-Tetrahydroxy-4-(Phosphonooxy)cyclohexyl]oxy}phosphoryl]oxy}propan-2-Yl (5z,8z,11z,14z)-Icosa-5,8,11,14-Tetraenoate |
small-molecule small-molecule |
Agonist PAM |
5-hydroxytryptamine | small-molecule | No | No | - | - | 2024-05-29 | Yes | |
| 5HT2A | 5-HT2A | 5-Hydroxytryptamine | A | Human | Cryo-EM | 8V6U | - | 3.0 | A | Active | 100 | 55 | Gq/11 | αq | Gi2-mini-Gq chimera | 57 | - | scFv16 |
4-{(3R)-1-[(1R)-1-(pyrimidin-2-yl)ethyl]piperidin-3-yl}phenol
|
small-molecule | Agonist | tryptamine, 5-hydroxytryptamine | small-molecule | No | No | Lyu J, Kapolka N, Gumpper R, Alon A, Wang L, Jain MK, Barros-Alvarez X, Sakamoto K, Kim Y, DiBerto J, Kim K, Glenn IS, Tummino TA, Huang S, Irwin JJ, Tarkhanova OO, Moroz Y, Skiniotis G, Kruse AC, Shoichet BK, Roth BL | 10.1126/SCIENCE.ADN6354 | 2024-05-29 | Yes | |
| 5HT2A | 5-HT2A | 5-Hydroxytryptamine | A | Human | Cryo-EM | 8UWL | - | 2.8 | A | Active | 100 | 59 | Gq/11 | αq | Gi2-mini-Gq chimera | 58 | - | scFv16 |
lisuride
|
small-molecule | Agonist | tryptamine, 5-hydroxytryptamine | small-molecule | No | No | Lyu J, Kapolka N, Gumpper R, Alon A, Wang L, Jain MK, Barros-Alvarez X, Sakamoto K, Kim Y, DiBerto J, Kim K, Glenn IS, Tummino TA, Huang S, Irwin JJ, Tarkhanova OO, Moroz Y, Skiniotis G, Kruse AC, Shoichet BK, Roth BL | 10.1126/SCIENCE.ADN6354 | 2024-05-29 | Yes | |
| OPRM | μ | Opioid | A | Human | Cryo-EM | 8K9K | - | 3.0 | R | Active | 100 | 70 | Gi/o | αi3 | - | 63 | BRIL | scFv16 |
DAMGO
|
peptide | Agonist | dynorphin B, dynorphin A-(1-13), dynorphin A-(1-8), β-endorphin, [Met]enkephalin, dynorphin A, [Leu]enkephalin, endomorphin-1, endomorphin-2 | peptide | No | No | Kaneko S, Imai S, Uchikubo-Kamo T, Hisano T, Asao N, Shirouzu M, Shimada I | 10.1038/S41467-024-47792-6 | 2024-05-29 | Yes | |
| OPRM | μ | Opioid | A | Human | Cryo-EM | 8K9L | - | 3.1 | R | Active | 100 | 70 | Gi/o | αi3 | - | 63 | BRIL | scFv16 |
DAMGO
(2~{S})-2-(3-bromanyl-4-methoxy-phenyl)-3-(4-chlorophenyl)sulfonyl-1,3-thiazolidine |
peptide small-molecule |
Agonist PAM |
dynorphin B, dynorphin A-(1-13), dynorphin A-(1-8), β-endorphin, [Met]enkephalin, dynorphin A, [Leu]enkephalin, endomorphin-1, endomorphin-2 | peptide | No | No | Kaneko S, Imai S, Uchikubo-Kamo T, Hisano T, Asao N, Shirouzu M, Shimada I | 10.1038/S41467-024-47792-6 | 2024-05-29 | Yes | |
| SUCR1 | succinate | Succinate | A | Human | Cryo-EM | 8YKV | - | 2.5 | R | Active | 100 | 81 | Gi/o | αi1 | - | 60 | - | scFv16 |
CHEMBL5430997
|
small-molecule | Agonist | succinic acid | small-molecule | No | No | - | - | 2024-05-29 | Yes | |
| SUCR1 | succinate | Succinate | A | Human | Cryo-EM | 8YKW | 8YKW_refined | 2.8 | R | Active | 100 | 85 | Gi/o | αi1 | - | 60 | - | scFv16 |
succinic acid
|
small-molecule | Agonist | succinic acid | small-molecule | No | No | Li C, Liu H, Li J, He X, Zhu H, Fu W, Xu HE | 10.1038/S41422-024-00984-7 | 2024-05-29 | Yes | |
| SUCR1 | succinate | Succinate | A | Human | Cryo-EM | 8YKX | 8YKX_refined | 2.7 | R | Active | 100 | 84 | Gi/o | αi1 | - | 60 | - | scFv16 |
maleic acid
|
small-molecule | Agonist | succinic acid | small-molecule | No | No | Li C, Liu H, Li J, He X, Zhu H, Fu W, Xu HE | 10.1038/S41422-024-00984-7 | 2024-05-29 | Yes | |
| AGTR1 | AT1 | Angiotensin | A | Human | Cryo-EM | 8TH3 | - | 3.0 | A | Inactive | 8 | 81 | - | - | - | - | BRIL | BAG2 Anti-BRIL Fab Heavy chain BAG2 Anti-BRIL Fab Light chain |
AT118-H Nanobody
|
protein | Antagonist | angiotensin III, angiotensin IV, angiotensin A, angiotensin II | peptide | No | No | Skiba MA, Sterling SM, Rawson S, Zhang S, Xu H, Jiang H, Nemeth GR, Gilman MSA, Hurley JD, Shen P, Staus DP, Kim J, McMahon C, Lehtinen MK, Rockman HA, Barth P, Wingler LM, Kruse AC | 10.1038/S41589-024-01620-6 | 2024-05-22 | Yes | |
| AGTR1 | AT1 | Angiotensin | A | Human | Cryo-EM | 8TH4 | - | 3.3 | A | Inactive | 8 | 78 | - | - | - | - | BRIL | BAG2 Anti-BRIL Fab Heavy chain BAG2 Anti-BRIL Fab Light chain |
AT118-L Nanobody
|
protein | Antagonist | angiotensin III, angiotensin IV, angiotensin A, angiotensin II | peptide | No | No | Skiba MA, Sterling SM, Rawson S, Zhang S, Xu H, Jiang H, Nemeth GR, Gilman MSA, Hurley JD, Shen P, Staus DP, Kim J, McMahon C, Lehtinen MK, Rockman HA, Barth P, Wingler LM, Kruse AC | 10.1038/S41589-024-01620-6 | 2024-05-22 | Yes | |
| CCKAR | CCK1 | Cholecystokinin | A | Human | Cryo-EM | 9BKJ | - | 2.6 | R | Active | 100 | 66 | Gs | αs | Gs-Gi chimera | 52 | - | - |
CHEMBL216166
|
protein | Agonist | CCK-39, gastrin-17, desulfated cholecystokinin-8, CCK-4, CCK-58, CCK-8, CCK-33 | peptide | No | No | Harikumar KG, Zhao P, Cary BP, Xu X, Desai AJ, Dong M, Mobbs JI, Toufaily C, Furness SGB, Christopoulos A, Belousoff MJ, Wootten D, Sexton PM, Miller LJ | 10.1371/JOURNAL.PBIO.3002673 | 2024-05-22 | Yes | |
| CCKAR | CCK1 | Cholecystokinin | A | Human | Cryo-EM | 9BKK | - | 2.5 | R | Active | 100 | 66 | Gs | αs | - | 52 | - | - |
CHEMBL216166
|
protein | Agonist | CCK-39, gastrin-17, desulfated cholecystokinin-8, CCK-4, CCK-58, CCK-8, CCK-33 | peptide | No | No | Harikumar KG, Zhao P, Cary BP, Xu X, Desai AJ, Dong M, Mobbs JI, Toufaily C, Furness SGB, Christopoulos A, Belousoff MJ, Wootten D, Sexton PM, Miller LJ | 10.1371/JOURNAL.PBIO.3002673 | 2024-05-22 | Yes | |
| MRGX4 | MRGPRX4 | A orphans | A | Human | Cryo-EM | 8YRG | 8YRG_refined | 3.1 | R | Active | 100 | 74 | Gq/11 | αq | Gs-min-Gq chimera | 57 | BRIL | scFv16 |
Fospropofol
|
small-molecule | Agonist | - | - | No | No | - | - | 2024-05-22 | Yes | |
| SUCR1 | succinate | Succinate | A | Human | Cryo-EM | 8JPP | - | 3.2 | R | Active | 100 | 91 | Gs | αs | - | 60 | BRIL | - |
succinic acid
|
small-molecule | Agonist | succinic acid | small-molecule | No | No | Wang T, Tang W, Zhu X, Lv Z, Chen J, Li Y, Sun X, Lv H, Gu Q, Li F, Wang J | 10.1038/S41422-024-00968-7 | 2024-05-22 | Yes | |
| SUCR1 | succinate | Succinate | A | Human | Cryo-EM | 8JPN | - | 2.9 | R | Active | 100 | 89 | Gi/o | αi1 | - | 64 | BRIL | scFv16 |
cis-epoxysuccinic acid
|
small-molecule | Agonist | succinic acid | small-molecule | No | No | - | - | 2024-05-22 | Yes | |
| 5HT1A | 5-HT1A | 5-Hydroxytryptamine | A | Human | Cryo-EM | 8FY8 | - | 2.8 | R | Active | 100 | 68 | Gi/o | αi1 | - | 66 | BRIL | - |
5-MeO-DMT
|
small-molecule | Agonist | 5-hydroxytryptamine | small-molecule | No | No | Warren AL, Lankri D, Cunningham MJ, Serrano IC, Parise LF, Kruegel AC, Duggan P, Zilberg G, Capper MJ, Havel V, Russo SJ, Sames D, Wacker D | 10.1038/S41586-024-07403-2 | 2024-05-15 | Yes | |
| 5HT1A | 5-HT1A | 5-Hydroxytryptamine | A | Human | Cryo-EM | 8FYT | - | 2.6 | R | Active | 100 | 68 | Gi/o | αi1 | - | 66 | BRIL | - |
Lysergide
|
small-molecule | Agonist | 5-hydroxytryptamine | small-molecule | No | No | Warren AL, Lankri D, Cunningham MJ, Serrano IC, Parise LF, Kruegel AC, Duggan P, Zilberg G, Capper MJ, Havel V, Russo SJ, Sames D, Wacker D | 10.1038/S41586-024-07403-2 | 2024-05-15 | Yes | |
| 5HT1A | 5-HT1A | 5-Hydroxytryptamine | A | Human | Cryo-EM | 8FYL | - | 2.9 | R | Active | 100 | 68 | Gi/o | αi1 | - | 66 | BRIL | - |
vilazodone
|
small-molecule | Agonist | 5-hydroxytryptamine | small-molecule | No | No | Warren AL, Lankri D, Cunningham MJ, Serrano IC, Parise LF, Kruegel AC, Duggan P, Zilberg G, Capper MJ, Havel V, Russo SJ, Sames D, Wacker D | 10.1038/S41586-024-07403-2 | 2024-05-15 | Yes | |
| 5HT1A | 5-HT1A | 5-Hydroxytryptamine | A | Human | Cryo-EM | 8FYE | - | 2.9 | R | Active | 100 | 68 | Gi/o | αi1 | - | 66 | BRIL | - |
CHEMBL352186
|
small-molecule | Agonist | 5-hydroxytryptamine | small-molecule | No | No | Warren AL, Lankri D, Cunningham MJ, Serrano IC, Parise LF, Kruegel AC, Duggan P, Zilberg G, Capper MJ, Havel V, Russo SJ, Sames D, Wacker D | 10.1038/S41586-024-07403-2 | 2024-05-15 | Yes | |
| 5HT1A | 5-HT1A | 5-Hydroxytryptamine | A | Human | Cryo-EM | 8FYX | - | 2.6 | R | Active | 100 | 68 | Gi/o | αi1 | - | 66 | BRIL | - |
buspirone
|
small-molecule | Agonist | 5-hydroxytryptamine | small-molecule | No | No | Warren AL, Lankri D, Cunningham MJ, Serrano IC, Parise LF, Kruegel AC, Duggan P, Zilberg G, Capper MJ, Havel V, Russo SJ, Sames D, Wacker D | 10.1038/S41586-024-07403-2 | 2024-05-15 | Yes | |
| GPR34 | GPR34 | A orphans | A | Human | Cryo-EM | 8XBE | 8XBE_refined | 3.4 | A | Active | 100 | 78 | Gi/o | αi1 | - | 62 | - | scFv16 |
CHEMBL4782438
|
small-molecule | Agonist | lysophosphatidylserine | small-molecule | No | No | Izume T, Kawahara R, Uwamizu A, Chen L, Yaginuma S, Omi J, Kawana H, Hou F, Sano FK, Tanaka T, Kobayashi K, Okamoto HH, Kise Y, Ohwada T, Aoki J, Shihoya W, Nureki O | 10.1038/S41467-024-45046-Z | 2024-05-15 | Yes | |
| GPR34 | GPR34 | A orphans | A | Human | Cryo-EM | 8XBG | - | 3.4 | A | Active | 60 | 78 | - | - | - | - | - | - |
CHEMBL4782438
|
small-molecule | Agonist | lysophosphatidylserine | small-molecule | No | No | Izume T, Kawahara R, Uwamizu A, Chen L, Yaginuma S, Omi J, Kawana H, Hou F, Sano FK, Tanaka T, Kobayashi K, Okamoto HH, Kise Y, Ohwada T, Aoki J, Shihoya W, Nureki O | 10.1038/S41467-024-45046-Z | 2024-05-15 | Yes | |
| 5HT1E | 5-HT1E | 5-Hydroxytryptamine | A | Human | Cryo-EM | 8UH3 | - | 3.3 | D | Active | 100 | 74 | Gi/o | αi1 | - | 61 | - | scFv16 |
SETIPTILINE
|
small-molecule | Agonist | tryptamine, 5-hydroxytryptamine | small-molecule | No | No | Zilberg G, Parpounas AK, Warren AL, Fiorillo B, Provasi D, Filizola M, Wacker D | 10.1126/SCIADV.ADK4855 | 2024-05-01 | Yes | |
| 5HT1E | 5-HT1E | 5-Hydroxytryptamine | A | Human | Cryo-EM | 8UGY | - | 3.3 | R | Active | 100 | 72 | Gi/o | αi1 | - | 61 | - | - |
CHEMBL252719
|
small-molecule | Agonist | tryptamine, 5-hydroxytryptamine | small-molecule | No | No | Zilberg G, Parpounas AK, Warren AL, Fiorillo B, Provasi D, Filizola M, Wacker D | 10.1126/SCIADV.ADK4855 | 2024-05-01 | Yes | |
| AA3R | A3 | Adenosine | A | Human | Cryo-EM | 8X17 | 8X17_refined | 3.2 | R | Active | 100 | 89 | Gi/o | αi1 | - | 61 | - | scFv16 |
Cl-IB-MECA
|
small-molecule | Agonist | adenosine | small-molecule | No | No | Cai H, Guo S, Xu Y, Sun J, Li J, Xia Z, Jiang Y, Xie X, Xu HE | 10.1038/S41467-024-47207-6 | 2024-04-24 | Yes | |
| AA3R | A3 | Adenosine | A | Human | Cryo-EM | 8X16 | 8X16_refined | 3.3 | R | Active | 100 | 88 | Gi/o | αi1 | - | 61 | - | scFv16 |
piclidenoson
|
small-molecule | Agonist | adenosine | small-molecule | No | No | Cai H, Guo S, Xu Y, Sun J, Li J, Xia Z, Jiang Y, Xie X, Xu HE | 10.1038/S41467-024-47207-6 | 2024-04-24 | Yes | |
| CALCR | CT | Calcitonin | B1 | Human | Cryo-EM | 9AUC | - | 2.4 | R | Active | 100 | 78 | Gs | αs | - | 59 | - | Nanobody-35 RAMP1 |
Calcitonin gene-related peptide 1
|
peptide | Agonist | adrenomedullin, calcitonin, β-CGRP, adrenomedullin 2/intermedin, α-CGRP, amylin | peptide | No | No | Cao J, Belousoff MJ, Danev R, Christopoulos A, Wootten D, Sexton PM | 10.1021/ACS.BIOCHEM.4C00114 | 2024-04-24 | Yes | |
| FZD7 | FZD7 | Frizzled | F | Human | Cryo-EM | 8YY8 | - | 3.2 | R | Active | 100 | 59 | Gs | αs | - | 59 | - | Nanobody-35 |
Apo (no ligand)
|
none | Apo (no ligand) | - | - | No | No | Xu L, Chen B, Schihada H, Wright SC, Turku A, Wu Y, Han GW, Kowalski-Jahn M, Kozielewicz P, Bowin CF, Zhang X, Li C, Bouvier M, Schulte G, Xu F | 10.1038/S41422-021-00525-6 | 2024-04-24 | Yes | |
| CASR | CaS | Calcium-sensing | C | Human | Cryo-EM | 9AYF | - | 3.6 | R | Active | - | 76 | Gi/o | αi1 | - | 60 | - | scFv16 |
Cyclomethyltryptophan
tecalcet |
small-molecule small-molecule |
Agonist PAM |
Mg2+, L-tryptophan, spermine, Ca2+ | small-molecule | No | No | Zuo H, Park J, Frangaj A, Ye J, Lu G, Manning JJ, Asher WB, Lu Z, Hu GB, Wang L, Mendez J, Eng E, Zhang Z, Lin X, Grassucci R, Hendrickson WA, Clarke OB, Javitch JA, Conigrave AD, Fan QR | 10.1038/S41586-024-07331-1 | 2024-04-17 | Yes | |
| CASR | CaS | Calcium-sensing | C | Human | Cryo-EM | 9ASB | - | 3.4 | R | Active | - | 75 | Gq/11 | αq | - | 60 | - | - |
Cyclomethyltryptophan
tecalcet |
small-molecule small-molecule |
Agonist PAM |
Mg2+, L-tryptophan, spermine, Ca2+ | small-molecule | No | No | - | - | 2024-04-17 | Yes | |
| CASR | CaS | Calcium-sensing | C | Human | Cryo-EM | 9AVG | - | 3.6 | R | Active | - | 74 | Gs | αs | - | 57 | - | - |
Cyclomethyltryptophan
tecalcet |
small-molecule small-molecule |
Agonist PAM |
Mg2+, L-tryptophan, spermine, Ca2+ | small-molecule | No | No | - | - | 2024-04-17 | Yes | |
| CASR | CaS | Calcium-sensing | C | Human | Cryo-EM | 9AXF | - | 3.5 | R | Active | - | 77 | Gq/11 | αq | Gq-Gs-Gi chimera | 59 | - | scFv16 |
Cyclomethyltryptophan
tecalcet |
small-molecule small-molecule |
Agonist PAM |
Mg2+, L-tryptophan, spermine, Ca2+ | small-molecule | No | No | Zuo H, Park J, Frangaj A, Ye J, Lu G, Manning JJ, Asher WB, Lu Z, Hu GB, Wang L, Mendez J, Eng E, Zhang Z, Lin X, Grassucci R, Hendrickson WA, Clarke OB, Javitch JA, Conigrave AD, Fan QR | 10.1038/S41586-024-07331-1 | 2024-04-17 | Yes | |
| CASR | CaS | Calcium-sensing | C | Human | Cryo-EM | 9AVL | - | 3.8 | R | Active | - | 76 | Gi/o | αi3 | - | 64 | - | - |
Cyclomethyltryptophan
tecalcet |
small-molecule small-molecule |
Agonist PAM |
Mg2+, L-tryptophan, spermine, Ca2+ | small-molecule | No | No | - | - | 2024-04-17 | Yes | |
| FFAR2 | FFA2 | Free fatty acid | A | Human | Cryo-EM | 8J23 | 8J23_refined | 3.2 | A | Active | 100 | 78 | Gi/o | αi1 | - | 61 | - | scFv16 |
Apo (no ligand)
|
none | Apo (no ligand) | butyric acid, acetic acid, trans-2-methylcrotonic acid, propanoic acid | small-molecule | No | No | - | - | 2024-04-17 | Yes | |
| GPER1 | GPER | Estrogen (G protein-coupled) | A | Human | Cryo-EM | 8XOJ | 8XOJ_refined | 3.1 | R | Active | 100 | 71 | Gq/11 | αq | - | 59 | - | scFv16 | - | - | - | 17β-estradiol | small-molecule | No | No | Liu H, Guo S, Dai A, Xu P, Li X, Huang S, He X, Wu K, Zhang X, Yang D, Xie X, Xu HE | 10.1038/S41422-024-00963-Y | 2024-04-10 | Yes | |
| GPER1 | GPER | Estrogen (G protein-coupled) | A | Human | Cryo-EM | 8XOG | - | 2.9 | R | Active | 100 | 70 | Gq/11 | αq | - | 59 | - | scFv16 |
Apo (no ligand)
|
none | Apo (no ligand) | 17β-estradiol | small-molecule | No | No | Liu H, Guo S, Dai A, Xu P, Li X, Huang S, He X, Wu K, Zhang X, Yang D, Xie X, Xu HE | 10.1038/S41422-024-00963-Y | 2024-04-10 | Yes | |
| GPER1 | GPER | Estrogen (G protein-coupled) | A | Human | Cryo-EM | 8XOI | 8XOI_refined | 3.2 | R | Active | 100 | 70 | Gq/11 | αq | - | 59 | - | scFv16 |
fulvestrant
|
small-molecule | Agonist | 17β-estradiol | small-molecule | No | No | Liu H, Guo S, Dai A, Xu P, Li X, Huang S, He X, Wu K, Zhang X, Yang D, Xie X, Xu HE | 10.1038/S41422-024-00963-Y | 2024-04-10 | Yes | |
| GPER1 | GPER | Estrogen (G protein-coupled) | A | Human | Cryo-EM | 8XOH | 8XOH_refined | 3.2 | R | Active | 100 | 71 | Gq/11 | αq | - | 59 | - | scFv16 |
PGE2
|
small-molecule | Agonist | 17β-estradiol | small-molecule | No | No | Liu H, Guo S, Dai A, Xu P, Li X, Huang S, He X, Wu K, Zhang X, Yang D, Xie X, Xu HE | 10.1038/S41422-024-00963-Y | 2024-04-10 | Yes | |
| GPER1 | GPER | Estrogen (G protein-coupled) | A | Human | Cryo-EM | 8XOF | 8XOF_refined | 2.6 | R | Active | 100 | 71 | Gq/11 | αq | - | 59 | - | Nanobody-35 |
N1-(7-Chloroquinolin-4-yl)-N2-(2-((7-chloroquinolin-4-yl)amino)ethyl)-N2-methylethane-1,2-diamine
|
small-molecule | Agonist | 17β-estradiol | small-molecule | No | No | - | - | 2024-04-10 | Yes | |
| GPR34 | GPR34 | A orphans | A | Human | Cryo-EM | 8IZ4 | - | 2.9 | R | Active | 100 | 74 | Gi/o | αi1 | - | 63 | - | scFv16 |
Lysergide
|
small-molecule | Agonist | lysophosphatidylserine | small-molecule | No | No | - | - | 2024-04-10 | Yes | |
| AA2AR | A2A | Adenosine | A | Human | X-ray | 8RQQ | - | 2.4 | A | Inactive | 1 | 72 | - | - | - | - | BRIL | - |
ZM-241385
|
small-molecule | Antagonist | adenosine | small-molecule | No | No | - | - | 2024-04-03 | Yes | |
| EDNRB | ETB | Endothelin | A | Human | Cryo-EM | 8XGR | - | 3.2 | R | Active | 100 | 69 | Gi/o | αt1 | - | 59 | - | Camelid antibody VHH fragment |
ENDOTHELIN
|
protein | Agonist | endothelin-2, endothelin-3, endothelin-1 | peptide | No | No | - | - | 2024-04-03 | Yes | |
| GPR3 | GPR3 | A orphans | A | Human | Cryo-EM | 8X2K | - | 3.0 | A | Active | 100 | 79 | Gs | αs | - | 55 | BRIL | scFv16 |
N-oleoylethanolamide
|
small-molecule | Agonist | sphingosine 1-phosphate | small-molecule | No | No | Chen G, Staffen N, Wu Z, Xu X, Pan J, Inoue A, Shi T, Gmeiner P, Du Y, Xu J | 10.1038/S41422-023-00919-8 | 2024-04-03 | Yes | |
| HCAR2 | HCA2 | Hydroxycarboxylic acid | A | Human | Cryo-EM | 8J6I | 8J6I_refined | 2.9 | R | Active | 100 | 79 | Gi/o | αi1 | - | 61 | - | scFv16 |
MK 6892
|
small-molecule | Agonist | butyric acid, β-D-hydroxybutyric acid | small-molecule | No | No | - | - | 2024-04-03 | Yes | |
| HCAR2 | HCA2 | Hydroxycarboxylic acid | A | Human | Cryo-EM | 8J6L | 8J6L_refined | 3.1 | R | Active | 100 | 81 | Gi/o | αi1 | - | 61 | - | scFv16 |
nicotinic acid
|
small-molecule | Agonist | butyric acid, β-D-hydroxybutyric acid | small-molecule | No | No | Zhu S, Yuan Q, Li X, He X, Shen S, Wang D, Li J, Cheng X, Duan X, Xu HE, Duan J | 10.1016/J.CELREP.2023.113406 | 2024-04-03 | Yes | |
| T2R14 | TAS2R14 | Taste 2 | T2 | Human | Cryo-EM | 8VY9 | - | 2.9 | R | Active | 100 | 88 | Gi/o | αgust | - | 63 | - | scFv16 |
compound 28.1 [PMID: 36847646]
|
small-molecule | Agonist | - | - | No | No | - | - | 2024-04-03 | Yes | |
| T2R14 | TAS2R14 | Taste 2 | T2 | Human | Cryo-EM | 8VY7 | - | 2.7 | R | Active | 100 | 87 | Gi/o | αi1 | - | 63 | - | scFv16 |
compound 28.1 [PMID: 36847646]
|
small-molecule | Agonist | - | - | No | No | - | - | 2024-04-03 | Yes | |
| APJ | apelin | Apelin | A | Human | Cryo-EM | 8XZG | 8XZG_refined | 3.2 | R | Active | 100 | 79 | Gi/o | αi1 | - | 61 | - | - |
[Pyr1]apelin-13
|
peptide | Agonist | apelin-13, apelin-36, apelin-17, Elabela/Toddler-21, Elabela/Toddler-32, Elabela/Toddler-11, apelin receptor early endogenous ligand, [Pyr1]apelin-13 | peptide | No | No | Wang WW, Ji SY, Zhang W, Zhang J, Cai C, Hu R, Zang SK, Miao L, Xu H, Chen LN, Yang Z, Guo J, Qin J, Shen DD, Liang P, Zhang Y, Zhang Y | 10.1016/J.CELL.2024.02.004 | 2024-03-27 | Yes | |
| OPSR | OPN1LW | Opsins | A | Human | Cryo-EM | 8IU2 | 8IU2_refined | 3.4 | R | Active | 100 | 82 | Gi/o | αi1 | - | 59 | - | scFv16 |
Retinal (11-cis)
|
small-molecule | Agonist | - | - | No | No | - | - | 2024-03-27 | Yes | |
| APJ | apelin | Apelin | A | Human | Cryo-EM | 8XZJ | 8XZJ_refined | 3.0 | R | Active | 100 | 80 | Gi/o | αi1 | - | 62 | - | scFv16 |
WN353
|
peptide | Agonist | apelin-13, apelin-36, apelin-17, Elabela/Toddler-21, Elabela/Toddler-32, Elabela/Toddler-11, apelin receptor early endogenous ligand, [Pyr1]apelin-13 | peptide | No | No | Wang WW, Ji SY, Zhang W, Zhang J, Cai C, Hu R, Zang SK, Miao L, Xu H, Chen LN, Yang Z, Guo J, Qin J, Shen DD, Liang P, Zhang Y, Zhang Y | 10.1016/J.CELL.2024.02.004 | 2024-03-20 | Yes | |
| APJ | apelin | Apelin | A | Human | Cryo-EM | 8XZI | 8XZI_refined | 2.7 | R | Active | 100 | 81 | Gi/o | αi1 | - | 62 | - | - |
CMF-019
|
small-molecule | Agonist | apelin-13, apelin-36, apelin-17, Elabela/Toddler-21, Elabela/Toddler-32, Elabela/Toddler-11, apelin receptor early endogenous ligand, [Pyr1]apelin-13 | peptide | No | No | - | - | 2024-03-20 | Yes | |
| APJ | apelin | Apelin | A | Human | Cryo-EM | 8XZH | 8XZH_refined | 2.6 | R | Active | 100 | 80 | Gi/o | αi1 | - | 62 | - | scFv16 |
MM07
|
peptide | Agonist | apelin-13, apelin-36, apelin-17, Elabela/Toddler-21, Elabela/Toddler-32, Elabela/Toddler-11, apelin receptor early endogenous ligand, [Pyr1]apelin-13 | peptide | No | No | Wang WW, Ji SY, Zhang W, Zhang J, Cai C, Hu R, Zang SK, Miao L, Xu H, Chen LN, Yang Z, Guo J, Qin J, Shen DD, Liang P, Zhang Y, Zhang Y | 10.1016/J.CELL.2024.02.004 | 2024-03-20 | Yes | |
| APJ | apelin | Apelin | A | Human | Cryo-EM | 8XZF | 8XZF_refined | 3.0 | R | Active | 100 | 80 | Gi/o | αi1 | - | 61 | - | scFv16 |
WN561
|
peptide | Agonist | apelin-13, apelin-36, apelin-17, Elabela/Toddler-21, Elabela/Toddler-32, Elabela/Toddler-11, apelin receptor early endogenous ligand, [Pyr1]apelin-13 | peptide | No | No | Wang WW, Ji SY, Zhang W, Zhang J, Cai C, Hu R, Zang SK, Miao L, Xu H, Chen LN, Yang Z, Guo J, Qin J, Shen DD, Liang P, Zhang Y, Zhang Y | 10.1016/J.CELL.2024.02.004 | 2024-03-20 | Yes | |
| CNR1 | CB1 | Cannabinoid | A | Human | Cryo-EM | 8WU1 | - | 3.2 | R | Active | 100 | 57 | Beta | Beta-arrestin-1 | - | 86 | - | Fab heavy chain Fab light chain |
MDMB-Fubinaca
|
small-molecule | Agonist | 2-arachidonoylglycerol, anandamide | small-molecule | No | No | Liao YY, Zhang H, Shen Q, Cai C, Ding Y, Shen DD, Guo J, Qin J, Dong Y, Zhang Y, Li XM | 10.1016/J.CELL.2023.11.017 | 2024-03-20 | Yes | |
| GPR34 | GPR34 | A orphans | A | Human | Cryo-EM | 8IYX | - | 3.3 | C | Active | 56 | 70 | - | - | - | - | - | - |
YL-365
|
small-molecule | Antagonist | lysophosphatidylserine | small-molecule | No | No | Xia A, Yong X, Zhang C, Lin G, Jia G, Zhao C, Wang X, Hao Y, Wang Y, Zhou P, Yang X, Deng Y, Wu C, Chen Y, Zhu J, Tang X, Liu J, Zhang S, Zhang J, Xu Z, Hu Q, Zhao J, Yue Y, Yan W, Su Z, Wei Y, Zhou R, Dong H, Shao Z, Yang S | 10.1073/PNAS.2308435120 | 2024-03-20 | Yes | |
| HRH4 | H4 | Histamine | A | Human | Cryo-EM | 8JXV | - | 3.2 | R | Active | 100 | 68 | Gi/o | αi1 | - | 58 | - | scFv16 |
clozapine
|
small-molecule | Agonist | histamine, CCL16 | small-molecule | No | No | Xia R, Shi S, Xu Z, Vischer HF, Windhorst AD, Qian Y, Duan Y, Liang J, Chen K, Zhang A, Guo C, Leurs R, He Y | 10.1038/S41467-024-46840-5 | 2024-03-20 | Yes | |
| HRH4 | H4 | Histamine | A | Human | Cryo-EM | 8JXW | 8JXW_refined | 3.0 | R | Active | 100 | 69 | Gi/o | αi1 | - | 62 | - | scFv16 |
CHEMBL213912
|
small-molecule | Agonist | histamine, CCL16 | small-molecule | No | No | Xia R, Shi S, Xu Z, Vischer HF, Windhorst AD, Qian Y, Duan Y, Liang J, Chen K, Zhang A, Guo C, Leurs R, He Y | 10.1038/S41467-024-46840-5 | 2024-03-20 | Yes | |
| HRH4 | H4 | Histamine | A | Human | Cryo-EM | 8JXT | 8JXT_refined | 3.1 | R | Active | 100 | 69 | Gi/o | αi1 | - | 62 | - | scFv16 |
histamine
|
small-molecule | Agonist | histamine, CCL16 | small-molecule | No | No | Xia R, Shi S, Xu Z, Vischer HF, Windhorst AD, Qian Y, Duan Y, Liang J, Chen K, Zhang A, Guo C, Leurs R, He Y | 10.1038/S41467-024-46840-5 | 2024-03-20 | Yes | |
| HRH4 | H4 | Histamine | A | Human | Cryo-EM | 8JXX | 8JXX_refined | 3.1 | R | Active | 100 | 67 | Gi/o | αi1 | - | 62 | - | scFv16 |
clobenpropit
|
small-molecule | Agonist | histamine, CCL16 | small-molecule | No | No | Xia R, Shi S, Xu Z, Vischer HF, Windhorst AD, Qian Y, Duan Y, Liang J, Chen K, Zhang A, Guo C, Leurs R, He Y | 10.1038/S41467-024-46840-5 | 2024-03-20 | Yes | |
| CXCR4 | CXCR4 | Chemokine | A | Human | Cryo-EM | 8U4S | - | 3.4 | R | Active | 97 | 81 | - | - | - | - | - | REGN7663 Fab light chain |
REGN7663 Fab heavy chain
|
protein | Agonist | CXCL12, CXCL12β, CXCL12α, CXCL12φ, CXCL12γ, CXCL12δ, CXCL12ε | peptide | No | No | Saotome K, McGoldrick LL, Ho JH, Ramlall TF, Shah S, Moore MJ, Kim JH, Leidich R, Olson WC, Franklin MC | 10.1038/S41594-024-01397-1 | 2024-03-13 | Yes | |
| CXCR4 | CXCR4 | Chemokine | A | Human | Cryo-EM | 8U4O | - | 3.3 | R | Active | 100 | 84 | Gi/o | αi1 | - | 62 | - | - |
CXC12
|
protein | Agonist | CXCL12, CXCL12β, CXCL12α, CXCL12φ, CXCL12γ, CXCL12δ, CXCL12ε | peptide | No | No | Saotome K, McGoldrick LL, Ho JH, Ramlall TF, Shah S, Moore MJ, Kim JH, Leidich R, Olson WC, Franklin MC | 10.1038/S41594-024-01397-1 | 2024-03-13 | Yes | |
| CXCR4 | CXCR4 | Chemokine | A | Human | Cryo-EM | 8U4T | - | 3.4 | R | Inactive | 8 | 79 | - | - | - | - | - | REGN7663 Fab light chain |
REGN7663 Fab heavy chain
|
protein | Agonist | CXCL12, CXCL12β, CXCL12α, CXCL12φ, CXCL12γ, CXCL12δ, CXCL12ε | peptide | No | No | - | - | 2024-03-13 | Yes | |
| CXCR4 | CXCR4 | Chemokine | A | Human | Cryo-EM | 8U4P | - | 3.2 | R | Active | 100 | 81 | Gi/o | αi1 | - | 62 | - | - |
plerixafor
|
small-molecule | Agonist | CXCL12, CXCL12β, CXCL12α, CXCL12φ, CXCL12γ, CXCL12δ, CXCL12ε | peptide | No | No | Saotome K, McGoldrick LL, Ho JH, Ramlall TF, Shah S, Moore MJ, Kim JH, Leidich R, Olson WC, Franklin MC | 10.1038/S41594-024-01397-1 | 2024-03-13 | Yes | |
| CXCR4 | CXCR4 | Chemokine | A | Human | Cryo-EM | 8U4R | - | 3.1 | R | Inactive | 8 | 79 | - | - | - | - | - | REGN7663 Fab light chain |
REGN7663 Fab heavy chain
|
protein | Agonist | CXCL12, CXCL12β, CXCL12α, CXCL12φ, CXCL12γ, CXCL12δ, CXCL12ε | peptide | No | No | Saotome K, McGoldrick LL, Ho JH, Ramlall TF, Shah S, Moore MJ, Kim JH, Leidich R, Olson WC, Franklin MC | 10.1038/S41594-024-01397-1 | 2024-03-13 | Yes | |
| CXCR4 | CXCR4 | Chemokine | A | Human | Cryo-EM | 8U4Q | - | 3.4 | R | Active | 100 | 84 | Gi/o | αi1 | - | 62 | - | REGN7663 Fab light chain |
REGN7663 Fab heavy chain
|
protein | Agonist | CXCL12, CXCL12β, CXCL12α, CXCL12φ, CXCL12γ, CXCL12δ, CXCL12ε | peptide | No | No | Saotome K, McGoldrick LL, Ho JH, Ramlall TF, Shah S, Moore MJ, Kim JH, Leidich R, Olson WC, Franklin MC | 10.1038/S41594-024-01397-1 | 2024-03-13 | Yes | |
| CXCR4 | CXCR4 | Chemokine | A | Human | Cryo-EM | 8U4N | 8U4N_refined | 2.7 | R | Active | 100 | 80 | Gi/o | αi1 | - | 62 | - | - |
Apo (no ligand)
|
none | Apo (no ligand) | CXCL12, CXCL12β, CXCL12α, CXCL12φ, CXCL12γ, CXCL12δ, CXCL12ε | peptide | No | No | Saotome K, McGoldrick LL, Ho JH, Ramlall TF, Shah S, Moore MJ, Kim JH, Leidich R, Olson WC, Franklin MC | 10.1038/S41594-024-01397-1 | 2024-03-13 | Yes | |
| ADRB2 | β2 | Adrenoceptors | A | Human | Cryo-EM | 8GFX | - | 3.0 | R | Active | 100 | 68 | Gs | αs | - | 59 | - | - |
(5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol
|
small-molecule | Agonist | Zn2+, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline | small-molecule | No | No | Papasergi-Scott MM, Perez-Hernandez G, Batebi H, Gao Y, Eskici G, Seven AB, Panova O, Hilger D, Casiraghi M, He F, Maul L, Gmeiner P, Kobilka BK, Hildebrand PW, Skiniotis G | 10.1038/S41586-024-07153-1 | 2024-03-06 | Yes | |
| ADRB2 | β2 | Adrenoceptors | A | Human | Cryo-EM | 8GGT | - | 3.5 | R | Active | 96 | 68 | - | - | - | - | - | - |
(5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol
|
small-molecule | Agonist | Zn2+, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline | small-molecule | No | No | Papasergi-Scott MM, Perez-Hernandez G, Batebi H, Gao Y, Eskici G, Seven AB, Panova O, Hilger D, Casiraghi M, He F, Maul L, Gmeiner P, Kobilka BK, Hildebrand PW, Skiniotis G | 10.1038/S41586-024-07153-1 | 2024-03-06 | Yes | |
| ADRB2 | β2 | Adrenoceptors | A | Human | Cryo-EM | 8GEF | 8GEF_refined | 3.8 | R | Active | 100 | 68 | Gs | αs | - | 71 | - | - |
(5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol
|
small-molecule | Agonist | Zn2+, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline | small-molecule | No | No | Papasergi-Scott MM, Perez-Hernandez G, Batebi H, Gao Y, Eskici G, Seven AB, Panova O, Hilger D, Casiraghi M, He F, Maul L, Gmeiner P, Kobilka BK, Hildebrand PW, Skiniotis G | 10.1038/S41586-024-07153-1 | 2024-03-06 | Yes | |
| ADRB2 | β2 | Adrenoceptors | A | Human | Cryo-EM | 8GGN | - | 3.3 | R | Active | 96 | 69 | - | - | - | - | - | - |
(5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol
|
small-molecule | Agonist | Zn2+, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline | small-molecule | No | No | Papasergi-Scott MM, Perez-Hernandez G, Batebi H, Gao Y, Eskici G, Seven AB, Panova O, Hilger D, Casiraghi M, He F, Maul L, Gmeiner P, Kobilka BK, Hildebrand PW, Skiniotis G | 10.1038/S41586-024-07153-1 | 2024-03-06 | Yes | |
| ADRB2 | β2 | Adrenoceptors | A | Human | Cryo-EM | 8GEB | 8GEB_refined | 3.6 | R | Active | 100 | 68 | Gs | αs | - | 59 | - | - |
(5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol
|
small-molecule | Agonist | Zn2+, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline | small-molecule | No | No | Papasergi-Scott MM, Perez-Hernandez G, Batebi H, Gao Y, Eskici G, Seven AB, Panova O, Hilger D, Casiraghi M, He F, Maul L, Gmeiner P, Kobilka BK, Hildebrand PW, Skiniotis G | 10.1038/S41586-024-07153-1 | 2024-03-06 | Yes | |
| ADRB2 | β2 | Adrenoceptors | A | Human | Cryo-EM | 8GGA | 8GGA_refined | 3.5 | R | Active | 100 | 65 | Gs | αs | - | 83 | - | - |
(5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol
|
small-molecule | Agonist | Zn2+, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline | small-molecule | No | No | Papasergi-Scott MM, Perez-Hernandez G, Batebi H, Gao Y, Eskici G, Seven AB, Panova O, Hilger D, Casiraghi M, He F, Maul L, Gmeiner P, Kobilka BK, Hildebrand PW, Skiniotis G | 10.1038/S41586-024-07153-1 | 2024-03-06 | Yes | |
| ADRB2 | β2 | Adrenoceptors | A | Human | Cryo-EM | 8UO0 | - | 3.5 | R | Active | 100 | 69 | Gs | αs | GTP bound, Class P | 58 | - | - |
(5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol
|
small-molecule | Agonist | Zn2+, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline | small-molecule | No | No | Papasergi-Scott MM, Perez-Hernandez G, Batebi H, Gao Y, Eskici G, Seven AB, Panova O, Hilger D, Casiraghi M, He F, Maul L, Gmeiner P, Kobilka BK, Hildebrand PW, Skiniotis G | 10.1038/S41586-024-07153-1 | 2024-03-06 | Yes | |
| ADRB2 | β2 | Adrenoceptors | A | Human | Cryo-EM | 8GE7 | 8GE7_refined | 3.4 | R | Active | 100 | 68 | Gs | αs | - | 58 | - | - |
(5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol
|
small-molecule | Agonist | Zn2+, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline | small-molecule | No | No | Papasergi-Scott MM, Perez-Hernandez G, Batebi H, Gao Y, Eskici G, Seven AB, Panova O, Hilger D, Casiraghi M, He F, Maul L, Gmeiner P, Kobilka BK, Hildebrand PW, Skiniotis G | 10.1038/S41586-024-07153-1 | 2024-03-06 | Yes | |
| ADRB2 | β2 | Adrenoceptors | A | Human | Cryo-EM | 8GG9 | 8GG9_refined | 3.4 | R | Active | 100 | 68 | Gs | αs | - | 76 | - | - |
(5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol
|
small-molecule | Agonist | Zn2+, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline | small-molecule | No | No | Papasergi-Scott MM, Perez-Hernandez G, Batebi H, Gao Y, Eskici G, Seven AB, Panova O, Hilger D, Casiraghi M, He F, Maul L, Gmeiner P, Kobilka BK, Hildebrand PW, Skiniotis G | 10.1038/S41586-024-07153-1 | 2024-03-06 | Yes | |
| ADRB2 | β2 | Adrenoceptors | A | Human | Cryo-EM | 8GFV | - | 3.1 | R | Active | 100 | 68 | Gs | αs | - | 59 | - | - |
(5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol
|
small-molecule | Agonist | Zn2+, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline | small-molecule | No | No | Papasergi-Scott MM, Perez-Hernandez G, Batebi H, Gao Y, Eskici G, Seven AB, Panova O, Hilger D, Casiraghi M, He F, Maul L, Gmeiner P, Kobilka BK, Hildebrand PW, Skiniotis G | 10.1038/S41586-024-07153-1 | 2024-03-06 | Yes | |
| ADRB2 | β2 | Adrenoceptors | A | Human | Cryo-EM | 8GGS | - | 3.5 | R | Active | 96 | 68 | - | - | - | - | - | - |
(5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol
|
small-molecule | Agonist | Zn2+, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline | small-molecule | No | No | Papasergi-Scott MM, Perez-Hernandez G, Batebi H, Gao Y, Eskici G, Seven AB, Panova O, Hilger D, Casiraghi M, He F, Maul L, Gmeiner P, Kobilka BK, Hildebrand PW, Skiniotis G | 10.1038/S41586-024-07153-1 | 2024-03-06 | Yes | |
| ADRB2 | β2 | Adrenoceptors | A | Human | Cryo-EM | 8UNZ | 8UNZ_refined | 3.8 | R | Active | 100 | 69 | Gs | αs | GTP bound, Class O | 57 | - | - |
(5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol
|
small-molecule | Agonist | Zn2+, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline | small-molecule | No | No | Papasergi-Scott MM, Perez-Hernandez G, Batebi H, Gao Y, Eskici G, Seven AB, Panova O, Hilger D, Casiraghi M, He F, Maul L, Gmeiner P, Kobilka BK, Hildebrand PW, Skiniotis G | 10.1038/S41586-024-07153-1 | 2024-03-06 | Yes | |
| ADRB2 | β2 | Adrenoceptors | A | Human | Cryo-EM | 8GEG | 8GEG_refined | 3.8 | R | Active | 100 | 68 | Gs | αs | - | 78 | - | - |
(5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol
|
small-molecule | Agonist | Zn2+, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline | small-molecule | No | No | Papasergi-Scott MM, Perez-Hernandez G, Batebi H, Gao Y, Eskici G, Seven AB, Panova O, Hilger D, Casiraghi M, He F, Maul L, Gmeiner P, Kobilka BK, Hildebrand PW, Skiniotis G | 10.1038/S41586-024-07153-1 | 2024-03-06 | Yes | |
| ADRB2 | β2 | Adrenoceptors | A | Human | Cryo-EM | 8GGO | - | 3.2 | R | Active | 96 | 68 | - | - | - | - | - | - |
(5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol
|
small-molecule | Agonist | Zn2+, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline | small-molecule | No | No | Papasergi-Scott MM, Perez-Hernandez G, Batebi H, Gao Y, Eskici G, Seven AB, Panova O, Hilger D, Casiraghi M, He F, Maul L, Gmeiner P, Kobilka BK, Hildebrand PW, Skiniotis G | 10.1038/S41586-024-07153-1 | 2024-03-06 | Yes | |
| ADRB2 | β2 | Adrenoceptors | A | Human | Cryo-EM | 8UNY | - | 3.6 | R | Active | 100 | 69 | Gs | αs | GTP bound, Class N | 60 | - | - |
(5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol
|
small-molecule | Agonist | Zn2+, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline | small-molecule | No | No | Papasergi-Scott MM, Perez-Hernandez G, Batebi H, Gao Y, Eskici G, Seven AB, Panova O, Hilger D, Casiraghi M, He F, Maul L, Gmeiner P, Kobilka BK, Hildebrand PW, Skiniotis G | 10.1038/S41586-024-07153-1 | 2024-03-06 | Yes | |
| ADRB2 | β2 | Adrenoceptors | A | Human | Cryo-EM | 8GE6 | 8GE6_refined | 3.4 | R | Active | 100 | 67 | Gs | αs | - | 59 | - | - |
(5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol
|
small-molecule | Agonist | Zn2+, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline | small-molecule | No | No | Papasergi-Scott MM, Perez-Hernandez G, Batebi H, Gao Y, Eskici G, Seven AB, Panova O, Hilger D, Casiraghi M, He F, Maul L, Gmeiner P, Kobilka BK, Hildebrand PW, Skiniotis G | 10.1038/S41586-024-07153-1 | 2024-03-06 | Yes | |
| ADRB2 | β2 | Adrenoceptors | A | Human | Cryo-EM | 8GG7 | - | 3.3 | R | Active | 96 | 69 | - | - | - | - | - | - |
(5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol
|
small-molecule | Agonist | Zn2+, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline | small-molecule | No | No | Papasergi-Scott MM, Perez-Hernandez G, Batebi H, Gao Y, Eskici G, Seven AB, Panova O, Hilger D, Casiraghi M, He F, Maul L, Gmeiner P, Kobilka BK, Hildebrand PW, Skiniotis G | 10.1038/S41586-024-07153-1 | 2024-03-06 | Yes | |
| ADRB2 | β2 | Adrenoceptors | A | Human | Cryo-EM | 8GE4 | - | 3.3 | R | Active | 100 | 69 | Gs | αs | - | 59 | - | - |
(5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol
|
small-molecule | Agonist | Zn2+, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline | small-molecule | No | No | Papasergi-Scott MM, Perez-Hernandez G, Batebi H, Gao Y, Eskici G, Seven AB, Panova O, Hilger D, Casiraghi M, He F, Maul L, Gmeiner P, Kobilka BK, Hildebrand PW, Skiniotis G | 10.1038/S41586-024-07153-1 | 2024-03-06 | Yes | |
| ADRB2 | β2 | Adrenoceptors | A | Human | Cryo-EM | 8GG8 | - | 3.3 | R | Active | 100 | 69 | Gs | αs | - | 61 | - | - |
(5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol
|
small-molecule | Agonist | Zn2+, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline | small-molecule | No | No | Papasergi-Scott MM, Perez-Hernandez G, Batebi H, Gao Y, Eskici G, Seven AB, Panova O, Hilger D, Casiraghi M, He F, Maul L, Gmeiner P, Kobilka BK, Hildebrand PW, Skiniotis G | 10.1038/S41586-024-07153-1 | 2024-03-06 | Yes | |
| ADRB2 | β2 | Adrenoceptors | A | Human | Cryo-EM | 8UNL | - | 3.3 | R | Active | 100 | 68 | Gs | αs | GTP bound, Class A | 59 | - | - |
(5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol
|
small-molecule | Agonist | Zn2+, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline | small-molecule | No | No | Papasergi-Scott MM, Perez-Hernandez G, Batebi H, Gao Y, Eskici G, Seven AB, Panova O, Hilger D, Casiraghi M, He F, Maul L, Gmeiner P, Kobilka BK, Hildebrand PW, Skiniotis G | 10.1038/S41586-024-07153-1 | 2024-03-06 | Yes | |
| ADRB2 | β2 | Adrenoceptors | A | Human | Cryo-EM | 8GGF | 8GGF_refined | 3.6 | R | Active | 100 | 49 | Gs | αs | - | 91 | - | - |
(5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol
|
small-molecule | Agonist | Zn2+, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline | small-molecule | No | No | Papasergi-Scott MM, Perez-Hernandez G, Batebi H, Gao Y, Eskici G, Seven AB, Panova O, Hilger D, Casiraghi M, He F, Maul L, Gmeiner P, Kobilka BK, Hildebrand PW, Skiniotis G | 10.1038/S41586-024-07153-1 | 2024-03-06 | Yes | |
| ADRB2 | β2 | Adrenoceptors | A | Human | Cryo-EM | 8GH1 | - | 4.1 | R | Active | 95 | 68 | - | - | - | - | - | - |
(5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol
|
small-molecule | Agonist | Zn2+, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline | small-molecule | No | No | Papasergi-Scott MM, Perez-Hernandez G, Batebi H, Gao Y, Eskici G, Seven AB, Panova O, Hilger D, Casiraghi M, He F, Maul L, Gmeiner P, Kobilka BK, Hildebrand PW, Skiniotis G | 10.1038/S41586-024-07153-1 | 2024-03-06 | Yes | |
| ADRB2 | β2 | Adrenoceptors | A | Human | Cryo-EM | 8GEE | 8GEE_refined | 3.7 | R | Active | 100 | 68 | Gs | αs | - | 69 | - | - |
(5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol
|
small-molecule | Agonist | Zn2+, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline | small-molecule | No | No | Papasergi-Scott MM, Perez-Hernandez G, Batebi H, Gao Y, Eskici G, Seven AB, Panova O, Hilger D, Casiraghi M, He F, Maul L, Gmeiner P, Kobilka BK, Hildebrand PW, Skiniotis G | 10.1038/S41586-024-07153-1 | 2024-03-06 | Yes | |
| ADRB2 | β2 | Adrenoceptors | A | Human | Cryo-EM | 8GGK | - | 3.3 | R | Active | 96 | 70 | - | - | - | - | - | - |
(5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol
|
small-molecule | Agonist | Zn2+, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline | small-molecule | No | No | Papasergi-Scott MM, Perez-Hernandez G, Batebi H, Gao Y, Eskici G, Seven AB, Panova O, Hilger D, Casiraghi M, He F, Maul L, Gmeiner P, Kobilka BK, Hildebrand PW, Skiniotis G | 10.1038/S41586-024-07153-1 | 2024-03-06 | Yes | |
| ADRB2 | β2 | Adrenoceptors | A | Human | Cryo-EM | 8UNO | - | 3.3 | R | Active | 100 | 69 | Gs | αs | GTP bound, Class D | 57 | - | - |
(5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol
|
small-molecule | Agonist | Zn2+, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline | small-molecule | No | No | Papasergi-Scott MM, Perez-Hernandez G, Batebi H, Gao Y, Eskici G, Seven AB, Panova O, Hilger D, Casiraghi M, He F, Maul L, Gmeiner P, Kobilka BK, Hildebrand PW, Skiniotis G | 10.1038/S41586-024-07153-1 | 2024-03-06 | Yes | |
| ADRB2 | β2 | Adrenoceptors | A | Human | Cryo-EM | 8GEH | 8GEH_refined | 4.0 | R | Active | 100 | 67 | Gs | αs | - | 76 | - | - |
(5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol
|
small-molecule | Agonist | Zn2+, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline | small-molecule | No | No | Papasergi-Scott MM, Perez-Hernandez G, Batebi H, Gao Y, Eskici G, Seven AB, Panova O, Hilger D, Casiraghi M, He F, Maul L, Gmeiner P, Kobilka BK, Hildebrand PW, Skiniotis G | 10.1038/S41586-024-07153-1 | 2024-03-06 | Yes | |
| ADRB2 | β2 | Adrenoceptors | A | Human | Cryo-EM | 8GGM | - | 3.2 | R | Active | 96 | 69 | - | - | - | - | - | - |
(5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol
|
small-molecule | Agonist | Zn2+, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline | small-molecule | No | No | Papasergi-Scott MM, Perez-Hernandez G, Batebi H, Gao Y, Eskici G, Seven AB, Panova O, Hilger D, Casiraghi M, He F, Maul L, Gmeiner P, Kobilka BK, Hildebrand PW, Skiniotis G | 10.1038/S41586-024-07153-1 | 2024-03-06 | Yes | |
| ADRB2 | β2 | Adrenoceptors | A | Human | Cryo-EM | 8UO3 | 8UO3_refined | 3.5 | R | Active | 100 | 54 | Gs | αs | GTP bound, Class S | 91 | - | - |
(5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol
|
small-molecule | Agonist | Zn2+, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline | small-molecule | No | No | Papasergi-Scott MM, Perez-Hernandez G, Batebi H, Gao Y, Eskici G, Seven AB, Panova O, Hilger D, Casiraghi M, He F, Maul L, Gmeiner P, Kobilka BK, Hildebrand PW, Skiniotis G | 10.1038/S41586-024-07153-1 | 2024-03-06 | Yes | |
| ADRB2 | β2 | Adrenoceptors | A | Human | Cryo-EM | 8GG1 | - | 3.0 | R | Active | 100 | 68 | Gs | αs | - | 59 | - | - |
(5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol
|
small-molecule | Agonist | Zn2+, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline | small-molecule | No | No | Papasergi-Scott MM, Perez-Hernandez G, Batebi H, Gao Y, Eskici G, Seven AB, Panova O, Hilger D, Casiraghi M, He F, Maul L, Gmeiner P, Kobilka BK, Hildebrand PW, Skiniotis G | 10.1038/S41586-024-07153-1 | 2024-03-06 | Yes | |
| ADRB2 | β2 | Adrenoceptors | A | Human | Cryo-EM | 8GGY | - | 3.9 | R | Active | 96 | 68 | - | - | - | - | - | - |
(5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol
|
small-molecule | Agonist | Zn2+, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline | small-molecule | No | No | Papasergi-Scott MM, Perez-Hernandez G, Batebi H, Gao Y, Eskici G, Seven AB, Panova O, Hilger D, Casiraghi M, He F, Maul L, Gmeiner P, Kobilka BK, Hildebrand PW, Skiniotis G | 10.1038/S41586-024-07153-1 | 2024-03-06 | Yes | |
| ADRB2 | β2 | Adrenoceptors | A | Human | Cryo-EM | 8UO2 | 8UO2_refined | 3.6 | R | Active | 100 | 68 | Gs | αs | GTP bound, Class R | 72 | - | - |
(5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol
|
small-molecule | Agonist | Zn2+, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline | small-molecule | No | No | Papasergi-Scott MM, Perez-Hernandez G, Batebi H, Gao Y, Eskici G, Seven AB, Panova O, Hilger D, Casiraghi M, He F, Maul L, Gmeiner P, Kobilka BK, Hildebrand PW, Skiniotis G | 10.1038/S41586-024-07153-1 | 2024-03-06 | Yes | |
| ADRB2 | β2 | Adrenoceptors | A | Human | Cryo-EM | 8GGL | - | 3.2 | R | Active | 96 | 69 | - | - | - | - | - | - |
(5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol
|
small-molecule | Agonist | Zn2+, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline | small-molecule | No | No | Papasergi-Scott MM, Perez-Hernandez G, Batebi H, Gao Y, Eskici G, Seven AB, Panova O, Hilger D, Casiraghi M, He F, Maul L, Gmeiner P, Kobilka BK, Hildebrand PW, Skiniotis G | 10.1038/S41586-024-07153-1 | 2024-03-06 | Yes | |
| ADRB2 | β2 | Adrenoceptors | A | Human | Cryo-EM | 8UNX | - | 3.6 | R | Active | 100 | 69 | Gs | αs | GTP bound, Class M | 62 | - | - |
(5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol
|
small-molecule | Agonist | Zn2+, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline | small-molecule | No | No | Papasergi-Scott MM, Perez-Hernandez G, Batebi H, Gao Y, Eskici G, Seven AB, Panova O, Hilger D, Casiraghi M, He F, Maul L, Gmeiner P, Kobilka BK, Hildebrand PW, Skiniotis G | 10.1038/S41586-024-07153-1 | 2024-03-06 | Yes | |
| ADRB2 | β2 | Adrenoceptors | A | Human | Cryo-EM | 8GE1 | - | 3.4 | R | Active | 100 | 70 | Gs | αs | - | 59 | - | - |
(5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol
|
small-molecule | Agonist | Zn2+, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline | small-molecule | No | No | Papasergi-Scott MM, Perez-Hernandez G, Batebi H, Gao Y, Eskici G, Seven AB, Panova O, Hilger D, Casiraghi M, He F, Maul L, Gmeiner P, Kobilka BK, Hildebrand PW, Skiniotis G | 10.1038/S41586-024-07153-1 | 2024-03-06 | Yes | |
| ADRB2 | β2 | Adrenoceptors | A | Human | Cryo-EM | 8GG2 | - | 3.0 | R | Active | 100 | 68 | Gs | αs | - | 59 | - | - |
(5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol
|
small-molecule | Agonist | Zn2+, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline | small-molecule | No | No | Papasergi-Scott MM, Perez-Hernandez G, Batebi H, Gao Y, Eskici G, Seven AB, Panova O, Hilger D, Casiraghi M, He F, Maul L, Gmeiner P, Kobilka BK, Hildebrand PW, Skiniotis G | 10.1038/S41586-024-07153-1 | 2024-03-06 | Yes | |
| ADRB2 | β2 | Adrenoceptors | A | Human | Cryo-EM | 8GGZ | - | 3.9 | R | Active | 96 | 68 | - | - | - | - | - | - |
(5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol
|
small-molecule | Agonist | Zn2+, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline | small-molecule | No | No | Papasergi-Scott MM, Perez-Hernandez G, Batebi H, Gao Y, Eskici G, Seven AB, Panova O, Hilger D, Casiraghi M, He F, Maul L, Gmeiner P, Kobilka BK, Hildebrand PW, Skiniotis G | 10.1038/S41586-024-07153-1 | 2024-03-06 | Yes | |
| ADRB2 | β2 | Adrenoceptors | A | Human | Cryo-EM | 8UNP | - | 3.3 | R | Active | 100 | 69 | Gs | αs | GTP bound, Class E | 60 | - | - |
(5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol
|
small-molecule | Agonist | Zn2+, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline | small-molecule | No | No | Papasergi-Scott MM, Perez-Hernandez G, Batebi H, Gao Y, Eskici G, Seven AB, Panova O, Hilger D, Casiraghi M, He F, Maul L, Gmeiner P, Kobilka BK, Hildebrand PW, Skiniotis G | 10.1038/S41586-024-07153-1 | 2024-03-06 | Yes | |
| ADRB2 | β2 | Adrenoceptors | A | Human | Cryo-EM | 8GFZ | - | 3.0 | R | Active | 100 | 67 | Gs | αs | - | 58 | - | - |
(5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol
|
small-molecule | Agonist | Zn2+, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline | small-molecule | No | No | Papasergi-Scott MM, Perez-Hernandez G, Batebi H, Gao Y, Eskici G, Seven AB, Panova O, Hilger D, Casiraghi M, He F, Maul L, Gmeiner P, Kobilka BK, Hildebrand PW, Skiniotis G | 10.1038/S41586-024-07153-1 | 2024-03-06 | Yes | |
| ADRB2 | β2 | Adrenoceptors | A | Human | Cryo-EM | 8GGU | - | 3.4 | R | Active | 96 | 68 | - | - | - | - | - | - |
(5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol
|
small-molecule | Agonist | Zn2+, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline | small-molecule | No | No | Papasergi-Scott MM, Perez-Hernandez G, Batebi H, Gao Y, Eskici G, Seven AB, Panova O, Hilger D, Casiraghi M, He F, Maul L, Gmeiner P, Kobilka BK, Hildebrand PW, Skiniotis G | 10.1038/S41586-024-07153-1 | 2024-03-06 | Yes | |
| ADRB2 | β2 | Adrenoceptors | A | Human | Cryo-EM | 8UNT | - | 3.4 | R | Active | 100 | 69 | Gs | αs | GTP bound, Class I | 60 | - | - |
(5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol
|
small-molecule | Agonist | Zn2+, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline | small-molecule | No | No | Papasergi-Scott MM, Perez-Hernandez G, Batebi H, Gao Y, Eskici G, Seven AB, Panova O, Hilger D, Casiraghi M, He F, Maul L, Gmeiner P, Kobilka BK, Hildebrand PW, Skiniotis G | 10.1038/S41586-024-07153-1 | 2024-03-06 | Yes | |
| ADRB2 | β2 | Adrenoceptors | A | Human | Cryo-EM | 8GE3 | - | 3.3 | R | Active | 100 | 69 | Gs | αs | - | 60 | - | - |
(5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol
|
small-molecule | Agonist | Zn2+, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline | small-molecule | No | No | Papasergi-Scott MM, Perez-Hernandez G, Batebi H, Gao Y, Eskici G, Seven AB, Panova O, Hilger D, Casiraghi M, He F, Maul L, Gmeiner P, Kobilka BK, Hildebrand PW, Skiniotis G | 10.1038/S41586-024-07153-1 | 2024-03-06 | Yes | |
| ADRB2 | β2 | Adrenoceptors | A | Human | Cryo-EM | 8GG5 | - | 3.2 | R | Active | 100 | 68 | Gs | αs | - | 60 | - | - |
(5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol
|
small-molecule | Agonist | Zn2+, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline | small-molecule | No | No | Papasergi-Scott MM, Perez-Hernandez G, Batebi H, Gao Y, Eskici G, Seven AB, Panova O, Hilger D, Casiraghi M, He F, Maul L, Gmeiner P, Kobilka BK, Hildebrand PW, Skiniotis G | 10.1038/S41586-024-07153-1 | 2024-03-06 | Yes | |
| ADRB2 | β2 | Adrenoceptors | A | Human | Cryo-EM | 8UNN | - | 3.4 | R | Active | 100 | 69 | Gs | αs | GTP bound, Class C | 59 | - | - |
(5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol
|
small-molecule | Agonist | Zn2+, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline | small-molecule | No | No | Papasergi-Scott MM, Perez-Hernandez G, Batebi H, Gao Y, Eskici G, Seven AB, Panova O, Hilger D, Casiraghi M, He F, Maul L, Gmeiner P, Kobilka BK, Hildebrand PW, Skiniotis G | 10.1038/S41586-024-07153-1 | 2024-03-06 | Yes | |
| ADRB2 | β2 | Adrenoceptors | A | Human | Cryo-EM | 8GFY | - | 3.0 | R | Active | 100 | 67 | Gs | αs | - | 58 | - | - |
(5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol
|
small-molecule | Agonist | Zn2+, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline | small-molecule | No | No | Papasergi-Scott MM, Perez-Hernandez G, Batebi H, Gao Y, Eskici G, Seven AB, Panova O, Hilger D, Casiraghi M, He F, Maul L, Gmeiner P, Kobilka BK, Hildebrand PW, Skiniotis G | 10.1038/S41586-024-07153-1 | 2024-03-06 | Yes | |
| ADRB2 | β2 | Adrenoceptors | A | Human | Cryo-EM | 8GGV | - | 3.5 | R | Active | 96 | 68 | - | - | - | - | - | - |
(5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol
|
small-molecule | Agonist | Zn2+, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline | small-molecule | No | No | Papasergi-Scott MM, Perez-Hernandez G, Batebi H, Gao Y, Eskici G, Seven AB, Panova O, Hilger D, Casiraghi M, He F, Maul L, Gmeiner P, Kobilka BK, Hildebrand PW, Skiniotis G | 10.1038/S41586-024-07153-1 | 2024-03-06 | Yes | |
| ADRB2 | β2 | Adrenoceptors | A | Human | Cryo-EM | 8UNQ | - | 3.3 | R | Active | 100 | 69 | Gs | αs | GTP bound, Class F | 61 | - | - |
(5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol
|
small-molecule | Agonist | Zn2+, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline | small-molecule | No | No | Papasergi-Scott MM, Perez-Hernandez G, Batebi H, Gao Y, Eskici G, Seven AB, Panova O, Hilger D, Casiraghi M, He F, Maul L, Gmeiner P, Kobilka BK, Hildebrand PW, Skiniotis G | 10.1038/S41586-024-07153-1 | 2024-03-06 | Yes | |
| ADRB2 | β2 | Adrenoceptors | A | Human | Cryo-EM | 8UO4 | 8UO4_refined | 4.0 | R | Active | 100 | 56 | Gs | αs | GTP bound, Class T | 74 | - | - |
(5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol
|
small-molecule | Agonist | Zn2+, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline | small-molecule | No | No | Papasergi-Scott MM, Perez-Hernandez G, Batebi H, Gao Y, Eskici G, Seven AB, Panova O, Hilger D, Casiraghi M, He F, Maul L, Gmeiner P, Kobilka BK, Hildebrand PW, Skiniotis G | 10.1038/S41586-024-07153-1 | 2024-03-06 | Yes | |
| ADRB2 | β2 | Adrenoceptors | A | Human | Cryo-EM | 8GEJ | 8GEJ_refined | 4.2 | R | Active | 100 | 65 | Gs | αs | - | 79 | - | - |
(5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol
|
small-molecule | Agonist | Zn2+, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline | small-molecule | No | No | Papasergi-Scott MM, Perez-Hernandez G, Batebi H, Gao Y, Eskici G, Seven AB, Panova O, Hilger D, Casiraghi M, He F, Maul L, Gmeiner P, Kobilka BK, Hildebrand PW, Skiniotis G | 10.1038/S41586-024-07153-1 | 2024-03-06 | Yes | |
| ADRB2 | β2 | Adrenoceptors | A | Human | Cryo-EM | 8GGQ | - | 3.4 | R | Active | 96 | 68 | - | - | - | - | - | - |
(5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol
|
small-molecule | Agonist | Zn2+, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline | small-molecule | No | No | Papasergi-Scott MM, Perez-Hernandez G, Batebi H, Gao Y, Eskici G, Seven AB, Panova O, Hilger D, Casiraghi M, He F, Maul L, Gmeiner P, Kobilka BK, Hildebrand PW, Skiniotis G | 10.1038/S41586-024-07153-1 | 2024-03-06 | Yes | |
| ADRB2 | β2 | Adrenoceptors | A | Human | Cryo-EM | 8UNW | - | 3.4 | R | Active | 100 | 68 | Gs | αs | GTP bound, Class L | 59 | - | - |
(5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol
|
small-molecule | Agonist | Zn2+, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline | small-molecule | No | No | Papasergi-Scott MM, Perez-Hernandez G, Batebi H, Gao Y, Eskici G, Seven AB, Panova O, Hilger D, Casiraghi M, He F, Maul L, Gmeiner P, Kobilka BK, Hildebrand PW, Skiniotis G | 10.1038/S41586-024-07153-1 | 2024-03-06 | Yes | |
| ADRB2 | β2 | Adrenoceptors | A | Human | Cryo-EM | 8GDZ | - | 3.5 | R | Active | 100 | 69 | Gs | αs | - | 59 | - | - |
(5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol
|
small-molecule | Agonist | Zn2+, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline | small-molecule | No | No | Papasergi-Scott MM, Perez-Hernandez G, Batebi H, Gao Y, Eskici G, Seven AB, Panova O, Hilger D, Casiraghi M, He F, Maul L, Gmeiner P, Kobilka BK, Hildebrand PW, Skiniotis G | 10.1038/S41586-024-07153-1 | 2024-03-06 | Yes | |
| ADRB2 | β2 | Adrenoceptors | A | Human | Cryo-EM | 8GG0 | - | 2.9 | R | Active | 100 | 68 | Gs | αs | - | 59 | - | - |
(5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol
|
small-molecule | Agonist | Zn2+, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline | small-molecule | No | No | Papasergi-Scott MM, Perez-Hernandez G, Batebi H, Gao Y, Eskici G, Seven AB, Panova O, Hilger D, Casiraghi M, He F, Maul L, Gmeiner P, Kobilka BK, Hildebrand PW, Skiniotis G | 10.1038/S41586-024-07153-1 | 2024-03-06 | Yes | |
| ADRB2 | β2 | Adrenoceptors | A | Human | Cryo-EM | 8GGW | - | 3.6 | R | Active | 96 | 68 | - | - | - | - | - | - |
(5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol
|
small-molecule | Agonist | Zn2+, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline | small-molecule | No | No | Papasergi-Scott MM, Perez-Hernandez G, Batebi H, Gao Y, Eskici G, Seven AB, Panova O, Hilger D, Casiraghi M, He F, Maul L, Gmeiner P, Kobilka BK, Hildebrand PW, Skiniotis G | 10.1038/S41586-024-07153-1 | 2024-03-06 | Yes | |
| ADRB2 | β2 | Adrenoceptors | A | Human | Cryo-EM | 8GE2 | - | 3.3 | R | Active | 100 | 70 | Gs | αs | - | 59 | - | - |
(5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol
|
small-molecule | Agonist | Zn2+, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline | small-molecule | No | No | Papasergi-Scott MM, Perez-Hernandez G, Batebi H, Gao Y, Eskici G, Seven AB, Panova O, Hilger D, Casiraghi M, He F, Maul L, Gmeiner P, Kobilka BK, Hildebrand PW, Skiniotis G | 10.1038/S41586-024-07153-1 | 2024-03-06 | Yes | |
| ADRB2 | β2 | Adrenoceptors | A | Human | Cryo-EM | 8GG4 | - | 3.2 | R | Active | 100 | 68 | Gs | αs | - | 59 | - | - |
(5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol
|
small-molecule | Agonist | Zn2+, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline | small-molecule | No | No | Papasergi-Scott MM, Perez-Hernandez G, Batebi H, Gao Y, Eskici G, Seven AB, Panova O, Hilger D, Casiraghi M, He F, Maul L, Gmeiner P, Kobilka BK, Hildebrand PW, Skiniotis G | 10.1038/S41586-024-07153-1 | 2024-03-06 | Yes | |
| ADRB2 | β2 | Adrenoceptors | A | Human | Cryo-EM | 8GGX | - | 3.6 | R | Active | 96 | 68 | - | - | - | - | - | - |
(5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol
|
small-molecule | Agonist | Zn2+, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline | small-molecule | No | No | Papasergi-Scott MM, Perez-Hernandez G, Batebi H, Gao Y, Eskici G, Seven AB, Panova O, Hilger D, Casiraghi M, He F, Maul L, Gmeiner P, Kobilka BK, Hildebrand PW, Skiniotis G | 10.1038/S41586-024-07153-1 | 2024-03-06 | Yes | |
| ADRB2 | β2 | Adrenoceptors | A | Human | Cryo-EM | 8GEI | - | 4.1 | R | Active | 100 | 68 | Gs | αs | - | 70 | - | - |
(5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol
|
small-molecule | Agonist | Zn2+, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline | small-molecule | No | No | Papasergi-Scott MM, Perez-Hernandez G, Batebi H, Gao Y, Eskici G, Seven AB, Panova O, Hilger D, Casiraghi M, He F, Maul L, Gmeiner P, Kobilka BK, Hildebrand PW, Skiniotis G | 10.1038/S41586-024-07153-1 | 2024-03-06 | Yes | |
| ADRB2 | β2 | Adrenoceptors | A | Human | Cryo-EM | 8GGP | - | 3.2 | R | Active | 96 | 68 | - | - | - | - | - | - |
(5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol
|
small-molecule | Agonist | Zn2+, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline | small-molecule | No | No | Papasergi-Scott MM, Perez-Hernandez G, Batebi H, Gao Y, Eskici G, Seven AB, Panova O, Hilger D, Casiraghi M, He F, Maul L, Gmeiner P, Kobilka BK, Hildebrand PW, Skiniotis G | 10.1038/S41586-024-07153-1 | 2024-03-06 | Yes | |
| ADRB2 | β2 | Adrenoceptors | A | Human | Cryo-EM | 8UNU | - | 3.5 | R | Active | 100 | 68 | Gs | αs | GTP bound, Class J | 57 | - | - |
(5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol
|
small-molecule | Agonist | Zn2+, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline | small-molecule | No | No | Papasergi-Scott MM, Perez-Hernandez G, Batebi H, Gao Y, Eskici G, Seven AB, Panova O, Hilger D, Casiraghi M, He F, Maul L, Gmeiner P, Kobilka BK, Hildebrand PW, Skiniotis G | 10.1038/S41586-024-07153-1 | 2024-03-06 | Yes | |
| ADRB2 | β2 | Adrenoceptors | A | Human | Cryo-EM | 8GED | 8GED_refined | 3.5 | R | Active | 100 | 68 | Gs | αs | - | 71 | - | - |
(5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol
|
small-molecule | Agonist | Zn2+, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline | small-molecule | No | No | Papasergi-Scott MM, Perez-Hernandez G, Batebi H, Gao Y, Eskici G, Seven AB, Panova O, Hilger D, Casiraghi M, He F, Maul L, Gmeiner P, Kobilka BK, Hildebrand PW, Skiniotis G | 10.1038/S41586-024-07153-1 | 2024-03-06 | Yes | |
| ADRB2 | β2 | Adrenoceptors | A | Human | Cryo-EM | 8GGJ | - | 3.5 | R | Active | 96 | 69 | - | - | - | - | - | - |
(5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol
|
small-molecule | Agonist | Zn2+, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline | small-molecule | No | No | Papasergi-Scott MM, Perez-Hernandez G, Batebi H, Gao Y, Eskici G, Seven AB, Panova O, Hilger D, Casiraghi M, He F, Maul L, Gmeiner P, Kobilka BK, Hildebrand PW, Skiniotis G | 10.1038/S41586-024-07153-1 | 2024-03-06 | Yes | |
| ADRB2 | β2 | Adrenoceptors | A | Human | Cryo-EM | 8GFW | - | 3.0 | R | Active | 100 | 68 | Gs | αs | - | 59 | - | - |
(5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol
|
small-molecule | Agonist | Zn2+, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline | small-molecule | No | No | Papasergi-Scott MM, Perez-Hernandez G, Batebi H, Gao Y, Eskici G, Seven AB, Panova O, Hilger D, Casiraghi M, He F, Maul L, Gmeiner P, Kobilka BK, Hildebrand PW, Skiniotis G | 10.1038/S41586-024-07153-1 | 2024-03-06 | Yes | |
| ADRB2 | β2 | Adrenoceptors | A | Human | Cryo-EM | 8GGR | - | 3.4 | R | Active | 96 | 68 | - | - | - | - | - | - |
(5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol
|
small-molecule | Agonist | Zn2+, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline | small-molecule | No | No | Papasergi-Scott MM, Perez-Hernandez G, Batebi H, Gao Y, Eskici G, Seven AB, Panova O, Hilger D, Casiraghi M, He F, Maul L, Gmeiner P, Kobilka BK, Hildebrand PW, Skiniotis G | 10.1038/S41586-024-07153-1 | 2024-03-06 | Yes | |
| ADRB2 | β2 | Adrenoceptors | A | Human | Cryo-EM | 8UNS | - | 3.4 | R | Active | 100 | 69 | Gs | αs | GTP bound, Class H | 61 | - | - |
(5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol
|
small-molecule | Agonist | Zn2+, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline | small-molecule | No | No | Papasergi-Scott MM, Perez-Hernandez G, Batebi H, Gao Y, Eskici G, Seven AB, Panova O, Hilger D, Casiraghi M, He F, Maul L, Gmeiner P, Kobilka BK, Hildebrand PW, Skiniotis G | 10.1038/S41586-024-07153-1 | 2024-03-06 | Yes | |
| ADRB2 | β2 | Adrenoceptors | A | Human | Cryo-EM | 8GE9 | 8GE9_refined | 3.5 | R | Active | 100 | 68 | Gs | αs | - | 60 | - | - |
(5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol
|
small-molecule | Agonist | Zn2+, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline | small-molecule | No | No | Papasergi-Scott MM, Perez-Hernandez G, Batebi H, Gao Y, Eskici G, Seven AB, Panova O, Hilger D, Casiraghi M, He F, Maul L, Gmeiner P, Kobilka BK, Hildebrand PW, Skiniotis G | 10.1038/S41586-024-07153-1 | 2024-03-06 | Yes | |
| ADRB2 | β2 | Adrenoceptors | A | Human | Cryo-EM | 8GGC | - | 3.4 | R | Active | 100 | 60 | Gs | αs | - | 75 | - | - |
(5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol
|
small-molecule | Agonist | Zn2+, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline | small-molecule | No | No | Papasergi-Scott MM, Perez-Hernandez G, Batebi H, Gao Y, Eskici G, Seven AB, Panova O, Hilger D, Casiraghi M, He F, Maul L, Gmeiner P, Kobilka BK, Hildebrand PW, Skiniotis G | 10.1038/S41586-024-07153-1 | 2024-03-06 | Yes | |
| ADRB2 | β2 | Adrenoceptors | A | Human | Cryo-EM | 8GEC | 8GEC_refined | 3.5 | R | Active | 100 | 68 | Gs | αs | - | 59 | - | - |
(5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol
|
small-molecule | Agonist | Zn2+, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline | small-molecule | No | No | Papasergi-Scott MM, Perez-Hernandez G, Batebi H, Gao Y, Eskici G, Seven AB, Panova O, Hilger D, Casiraghi M, He F, Maul L, Gmeiner P, Kobilka BK, Hildebrand PW, Skiniotis G | 10.1038/S41586-024-07153-1 | 2024-03-06 | Yes | |
| ADRB2 | β2 | Adrenoceptors | A | Human | Cryo-EM | 8GGI | - | 3.5 | R | Active | 96 | 69 | - | - | - | - | - | - |
(5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol
|
small-molecule | Agonist | Zn2+, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline | small-molecule | No | No | Papasergi-Scott MM, Perez-Hernandez G, Batebi H, Gao Y, Eskici G, Seven AB, Panova O, Hilger D, Casiraghi M, He F, Maul L, Gmeiner P, Kobilka BK, Hildebrand PW, Skiniotis G | 10.1038/S41586-024-07153-1 | 2024-03-06 | Yes | |
| ADRB2 | β2 | Adrenoceptors | A | Human | Cryo-EM | 8GE8 | 8GE8_refined | 3.4 | R | Active | 100 | 68 | Gs | αs | - | 60 | - | - |
(5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol
|
small-molecule | Agonist | Zn2+, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline | small-molecule | No | No | Papasergi-Scott MM, Perez-Hernandez G, Batebi H, Gao Y, Eskici G, Seven AB, Panova O, Hilger D, Casiraghi M, He F, Maul L, Gmeiner P, Kobilka BK, Hildebrand PW, Skiniotis G | 10.1038/S41586-024-07153-1 | 2024-03-06 | Yes | |
| ADRB2 | β2 | Adrenoceptors | A | Human | Cryo-EM | 8GGB | 8GGB_refined | 3.5 | R | Active | 100 | 64 | Gs | αs | - | 79 | - | - |
(5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol
|
small-molecule | Agonist | Zn2+, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline | small-molecule | No | No | Papasergi-Scott MM, Perez-Hernandez G, Batebi H, Gao Y, Eskici G, Seven AB, Panova O, Hilger D, Casiraghi M, He F, Maul L, Gmeiner P, Kobilka BK, Hildebrand PW, Skiniotis G | 10.1038/S41586-024-07153-1 | 2024-03-06 | Yes | |
| ADRB2 | β2 | Adrenoceptors | A | Human | Cryo-EM | 8UNM | - | 3.4 | R | Active | 100 | 69 | Gs | αs | GTP bound, Class B | 57 | - | - |
(5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol
|
small-molecule | Agonist | Zn2+, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline | small-molecule | No | No | Papasergi-Scott MM, Perez-Hernandez G, Batebi H, Gao Y, Eskici G, Seven AB, Panova O, Hilger D, Casiraghi M, He F, Maul L, Gmeiner P, Kobilka BK, Hildebrand PW, Skiniotis G | 10.1038/S41586-024-07153-1 | 2024-03-06 | Yes | |
| ADRB2 | β2 | Adrenoceptors | A | Human | Cryo-EM | 8GEA | 8GEA_refined | 3.5 | R | Active | 100 | 68 | Gs | αs | - | 61 | - | - |
(5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol
|
small-molecule | Agonist | Zn2+, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline | small-molecule | No | No | Papasergi-Scott MM, Perez-Hernandez G, Batebi H, Gao Y, Eskici G, Seven AB, Panova O, Hilger D, Casiraghi M, He F, Maul L, Gmeiner P, Kobilka BK, Hildebrand PW, Skiniotis G | 10.1038/S41586-024-07153-1 | 2024-03-06 | Yes | |
| ADRB2 | β2 | Adrenoceptors | A | Human | Cryo-EM | 8GGE | 8GGE_refined | 3.5 | R | Active | 100 | 56 | Gs | αs | - | 92 | - | - |
(5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol
|
small-molecule | Agonist | Zn2+, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline | small-molecule | No | No | Papasergi-Scott MM, Perez-Hernandez G, Batebi H, Gao Y, Eskici G, Seven AB, Panova O, Hilger D, Casiraghi M, He F, Maul L, Gmeiner P, Kobilka BK, Hildebrand PW, Skiniotis G | 10.1038/S41586-024-07153-1 | 2024-03-06 | Yes | |
| ADRB2 | β2 | Adrenoceptors | A | Human | Cryo-EM | 8UO1 | 8UO1_refined | 3.6 | R | Active | 100 | 68 | Gs | αs | GTP bound, Class Q | 85 | - | - |
(5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol
|
small-molecule | Agonist | Zn2+, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline | small-molecule | No | No | Papasergi-Scott MM, Perez-Hernandez G, Batebi H, Gao Y, Eskici G, Seven AB, Panova O, Hilger D, Casiraghi M, He F, Maul L, Gmeiner P, Kobilka BK, Hildebrand PW, Skiniotis G | 10.1038/S41586-024-07153-1 | 2024-03-06 | Yes | |
| ADRB2 | β2 | Adrenoceptors | A | Human | Cryo-EM | 8GG3 | - | 3.1 | R | Active | 100 | 68 | Gs | αs | - | 59 | - | - |
(5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol
|
small-molecule | Agonist | Zn2+, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline | small-molecule | No | No | Papasergi-Scott MM, Perez-Hernandez G, Batebi H, Gao Y, Eskici G, Seven AB, Panova O, Hilger D, Casiraghi M, He F, Maul L, Gmeiner P, Kobilka BK, Hildebrand PW, Skiniotis G | 10.1038/S41586-024-07153-1 | 2024-03-06 | Yes | |
| ADRB2 | β2 | Adrenoceptors | A | Human | Cryo-EM | 8GH0 | - | 4.0 | R | Active | 96 | 68 | - | - | - | - | - | - |
(5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol
|
small-molecule | Agonist | Zn2+, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline | small-molecule | No | No | Papasergi-Scott MM, Perez-Hernandez G, Batebi H, Gao Y, Eskici G, Seven AB, Panova O, Hilger D, Casiraghi M, He F, Maul L, Gmeiner P, Kobilka BK, Hildebrand PW, Skiniotis G | 10.1038/S41586-024-07153-1 | 2024-03-06 | Yes | |
| ADRB2 | β2 | Adrenoceptors | A | Human | Cryo-EM | 8UNR | - | 3.4 | R | Active | 100 | 69 | Gs | αs | GTP bound, Class G | 61 | - | - |
(5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol
|
small-molecule | Agonist | Zn2+, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline | small-molecule | No | No | Papasergi-Scott MM, Perez-Hernandez G, Batebi H, Gao Y, Eskici G, Seven AB, Panova O, Hilger D, Casiraghi M, He F, Maul L, Gmeiner P, Kobilka BK, Hildebrand PW, Skiniotis G | 10.1038/S41586-024-07153-1 | 2024-03-06 | Yes | |
| ADRB2 | β2 | Adrenoceptors | A | Human | Cryo-EM | 8UNV | - | 3.3 | R | Active | 100 | 69 | Gs | αs | GTP bound, Class K | 59 | - | - |
(5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol
|
small-molecule | Agonist | Zn2+, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline | small-molecule | No | No | Papasergi-Scott MM, Perez-Hernandez G, Batebi H, Gao Y, Eskici G, Seven AB, Panova O, Hilger D, Casiraghi M, He F, Maul L, Gmeiner P, Kobilka BK, Hildebrand PW, Skiniotis G | 10.1038/S41586-024-07153-1 | 2024-03-06 | Yes | |
| ADRB2 | β2 | Adrenoceptors | A | Human | Cryo-EM | 8GE5 | - | 3.2 | R | Active | 100 | 69 | Gs | αs | - | 59 | - | - |
(5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol
|
small-molecule | Agonist | Zn2+, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline | small-molecule | No | No | Papasergi-Scott MM, Perez-Hernandez G, Batebi H, Gao Y, Eskici G, Seven AB, Panova O, Hilger D, Casiraghi M, He F, Maul L, Gmeiner P, Kobilka BK, Hildebrand PW, Skiniotis G | 10.1038/S41586-024-07153-1 | 2024-03-06 | Yes | |
| ADRB2 | β2 | Adrenoceptors | A | Human | Cryo-EM | 8GG6 | - | 3.3 | R | Active | 100 | 68 | Gs | αs | - | 60 | - | - |
(5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol
|
small-molecule | Agonist | Zn2+, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline | small-molecule | No | No | Papasergi-Scott MM, Perez-Hernandez G, Batebi H, Gao Y, Eskici G, Seven AB, Panova O, Hilger D, Casiraghi M, He F, Maul L, Gmeiner P, Kobilka BK, Hildebrand PW, Skiniotis G | 10.1038/S41586-024-07153-1 | 2024-03-06 | Yes | |
| GIPR | GIP | Glucagon | B1 | Human | Cryo-EM | 8WA3 | 8WA3_refined | 2.9 | R | Active | 100 | 59 | Gs | αs | - | 59 | - | Nanobody-35 |
Apo (no ligand)
|
none | Apo (no ligand) | gastric inhibitory polypeptide | peptide | No | No | Cong Z, Zhao F, Li Y, Luo G, Mai Y, Chen X, Chen Y, Lin S, Cai X, Zhou Q, Yang D, Wang MW | 10.1038/S41421-024-00649-0 | 2024-03-06 | Yes | |
| GLP1R | GLP-1 | Glucagon | B1 | Human | Cryo-EM | 8WG7 | 8WG7_refined | 2.5 | R | Active | 100 | 60 | Gs | αs | - | 59 | - | Nanobody-35 |
Apo (no ligand)
|
none | Apo (no ligand) | glucagon-like peptide 1-(7-36) amide, glucagon, glucagon-like peptide 1-(7-37) | peptide | No | No | Cong Z, Zhao F, Li Y, Luo G, Mai Y, Chen X, Chen Y, Lin S, Cai X, Zhou Q, Yang D, Wang MW | 10.1038/S41421-024-00649-0 | 2024-03-06 | Yes | |
| GLR | glucagon | Glucagon | B1 | Human | Cryo-EM | 8WG8 | 8WG8_refined | 2.7 | R | Active | 100 | 55 | Gs | αs | - | 59 | - | Nanobody-35 |
Apo (no ligand)
|
none | Apo (no ligand) | glucagon | peptide | No | No | Cong Z, Zhao F, Li Y, Luo G, Mai Y, Chen X, Chen Y, Lin S, Cai X, Zhou Q, Yang D, Wang MW | 10.1038/S41421-024-00649-0 | 2024-03-06 | Yes | |
| GPR3 | GPR3 | A orphans | A | Human | Cryo-EM | 8U8F | 8U8F_refined | 3.5 | R | Active | 100 | 80 | Gs | αs | - | 59 | - | - |
palmitic acid
|
small-molecule | Agonist | sphingosine 1-phosphate | small-molecule | No | No | Russell IC, Zhang X, Bumbak F, McNeill SM, Josephs TM, Leeming MG, Christopoulos G, Venugopal H, Flocco MM, Sexton PM, Wootten D, Belousoff MJ | 10.1021/ACS.BIOCHEM.3C00647 | 2024-03-06 | Yes | |
| HCAR2 | HCA2 | Hydroxycarboxylic acid | A | Human | Cryo-EM | 8IYW | 8IYW_refined | 3.5 | R | Active | 100 | 80 | Gi/o | αo | - | 57 | - | scFv16 |
GSK256073
|
small-molecule | Agonist | butyric acid, β-D-hydroxybutyric acid | small-molecule | No | No | Yadav MK, Sarma P, Maharana J, Ganguly M, Mishra S, Zaidi N, Dalal A, Singh V, Saha S, Mahajan G, Sharma S, Chami M, Banerjee R, Shukla AK | 10.1038/S41467-024-46239-2 | 2024-03-06 | Yes | |
| HCAR2 | HCA2 | Hydroxycarboxylic acid | A | Human | Cryo-EM | 8JHN | 8JHN_refined | 3.8 | D | Active | 100 | 80 | Gi/o | αo | - | 58 | - | scFv16 |
monomethyl fumarate
|
small-molecule | Agonist | butyric acid, β-D-hydroxybutyric acid | small-molecule | No | No | Yadav MK, Sarma P, Maharana J, Ganguly M, Mishra S, Zaidi N, Dalal A, Singh V, Saha S, Mahajan G, Sharma S, Chami M, Banerjee R, Shukla AK | 10.1038/S41467-024-46239-2 | 2024-03-06 | Yes | |
| HCAR2 | HCA2 | Hydroxycarboxylic acid | A | Human | Cryo-EM | 8JER | 8JER_refined | 3.5 | R | Active | 100 | 80 | Gi/o | αo | - | 58 | - | scFv16 |
5-Methyl-4-oxidanyl-pyrazin-4-ium-2-carboxylic acid
|
small-molecule | Agonist | butyric acid, β-D-hydroxybutyric acid | small-molecule | No | No | Yadav MK, Sarma P, Maharana J, Ganguly M, Mishra S, Zaidi N, Dalal A, Singh V, Saha S, Mahajan G, Sharma S, Chami M, Banerjee R, Shukla AK | 10.1038/S41467-024-46239-2 | 2024-03-06 | Yes | |
| HCAR2 | HCA2 | Hydroxycarboxylic acid | A | Human | Cryo-EM | 8IYH | 8IYH_refined | 3.3 | D | Active | 100 | 79 | Gi/o | αo | - | 58 | - | scFv16 |
MK 6892
|
small-molecule | Agonist | butyric acid, β-D-hydroxybutyric acid | small-molecule | No | No | Yadav MK, Sarma P, Maharana J, Ganguly M, Mishra S, Zaidi N, Dalal A, Singh V, Saha S, Mahajan G, Sharma S, Chami M, Banerjee R, Shukla AK | 10.1038/S41467-024-46239-2 | 2024-03-06 | Yes | |
| HCAR2 | HCA2 | Hydroxycarboxylic acid | A | Human | Cryo-EM | 8IY9 | 8IY9_refined | 3.4 | R | Active | 100 | 82 | Gi/o | αo | - | 59 | - | scFv16 |
nicotinic acid
|
small-molecule | Agonist | butyric acid, β-D-hydroxybutyric acid | small-molecule | No | No | Yadav MK, Sarma P, Maharana J, Ganguly M, Mishra S, Zaidi N, Dalal A, Singh V, Saha S, Mahajan G, Sharma S, Chami M, Banerjee R, Shukla AK | 10.1038/S41467-024-46239-2 | 2024-03-06 | Yes | |
| HRH2 | H2 | Histamine | A | Human | Cryo-EM | 8POK | 8POK_refined | 3.4 | A | Active | 100 | 77 | Gs | αs | - | 56 | - | Nanobody-35 |
histamine
|
small-molecule | Agonist | histamine | small-molecule | No | No | Kock Z, Schnelle K, Persechino M, Umbach S, Schihada H, Januliene D, Parey K, Pockes S, Kolb P, Dotsch V, Moller A, Hilger D, Bernhard F | 10.1038/S41467-024-46096-Z | 2024-03-06 | Yes | |
| PI2R | IP | Prostanoid | A | Human | Cryo-EM | 8X7A | 8X7A_refined | 2.6 | R | Active | 100 | 74 | Gs | αs | - | 60 | - | Nanobody-35 |
treprostinil
|
small-molecule | Agonist | PGE1, PGF2α, PGI2, PGE2, thromboxane A2, PGD2 | small-molecule | No | No | Wang JJ, Jin S, Zhang H, Xu Y, Hu W, Jiang Y, Chen C, Wang DW, Xu HE, Wu C | 10.1126/SCIADV.ADK5184 | 2024-03-06 | Yes | |
| PI2R | IP | Prostanoid | A | Human | Cryo-EM | 8X79 | 8X79_refined | 2.4 | R | Active | 100 | 78 | Gs | αs | - | 59 | - | Nanobody-35 |
MRE-269
|
small-molecule | Agonist | PGE1, PGF2α, PGI2, PGE2, thromboxane A2, PGD2 | small-molecule | No | No | Wang JJ, Jin S, Zhang H, Xu Y, Hu W, Jiang Y, Chen C, Wang DW, Xu HE, Wu C | 10.1126/SCIADV.ADK5184 | 2024-03-06 | Yes | |
| 5HT1A | 5-HT1A | 5-Hydroxytryptamine | A | Human | Cryo-EM | 8JT6 | - | 3.0 | R | Active | 100 | 66 | Gi/o | αi1 | - | 62 | BRIL | scFv16 |
1-(4-fluorophenyl)-4-[(7R)-2,5,11-triazatetracyclo[7.6.1.0^2,7.0^12,16]hexadeca-1(15),9,12(16),13-tetraen-5-yl]butan-1-one
|
small-molecule | Agonist | 5-hydroxytryptamine | small-molecule | No | No | Chen Z, Yu J, Wang H, Xu P, Fan L, Sun F, Huang S, Zhang P, Huang H, Gu S, Zhang B, Zhou Y, Wan X, Pei G, Xu HE, Cheng J, Wang S | 10.1016/J.CELL.2024.02.034 | 2024-02-28 | Yes | |
| 5HT2A | 5-HT2A | 5-Hydroxytryptamine | A | Human | X-ray | 8JT8 | - | 2.7 | A | Inactive | 1 | 58 | - | - | - | - | BRIL | - |
1-(4-fluorophenyl)-4-[(7R)-2,5,11-triazatetracyclo[7.6.1.0^2,7.0^12,16]hexadeca-1(15),9,12(16),13-tetraen-5-yl]butan-1-one
|
small-molecule | Agonist | tryptamine, 5-hydroxytryptamine | small-molecule | No | No | Chen Z, Yu J, Wang H, Xu P, Fan L, Sun F, Huang S, Zhang P, Huang H, Gu S, Zhang B, Zhou Y, Wan X, Pei G, Xu HE, Cheng J, Wang S | 10.1016/J.CELL.2024.02.034 | 2024-02-28 | Yes | |
| CNR1 | CB1 | Cannabinoid | A | Human | Cryo-EM | 8GAG | 8GAG_refined | 3.3 | R | Active | 100 | 56 | Gi/o | αi1 | - | 62 | - | scFv16 |
methyl (2R)-2-({(1M)-5-methyl-1-[3-(trifluoromethyl)phenyl]-1H-pyrazole-3-carbonyl}amino)-2-(thiophen-2-yl)propanoate
|
small-molecule | Agonist | 2-arachidonoylglycerol, anandamide | small-molecule | No | No | - | - | 2024-02-28 | Yes | |
| CNR1 | CB1 | Cannabinoid | A | Human | Cryo-EM | 8WRZ | - | 3.6 | R | Active | 100 | 60 | Beta | Beta-arrestin-1 | - | 84 | BRIL | scFv30 |
AM841
|
small-molecule | Agonist | 2-arachidonoylglycerol, anandamide | small-molecule | No | No | Wang Y, Wu L, Wang T, Liu J, Li F, Jiang L, Fan Z, Yu Y, Chen N, Sun Q, Tan Q, Hua T, Liu ZJ | 10.1093/PROCEL/PWAD055 | 2024-02-28 | Yes | |
| NK3R | NK3 | Tachykinin | A | Human | Cryo-EM | 8JBF | - | 3.0 | B | Active | 100 | 61 | Gq/11 | αq | - | 59 | - | scFv16 |
senktide
|
peptide | Agonist | neurokinin A, neurokinin B, substance P | peptide | No | No | Sun W, Yang F, Zhang H, Yuan Q, Ling S, Wang Y, Lv P, Li Z, Luo Y, Liu D, Yin W, Shi P, Xu HE, Tian C | 10.1038/S41421-023-00564-W | 2024-02-28 | Yes | |
| PF2R | FP | Prostanoid | A | Human | Cryo-EM | 8XJM | 8XJM_refined | 2.9 | R | Active | 100 | 80 | Gq/11 | αq | - | 58 | - | scFv16 |
latanoprost (free acid form)
|
small-molecule | Agonist | PGF2α, PGI2, PGE2, thromboxane A2, PGD2 | small-molecule | No | No | Li X, Zhang X, Wen X, Zhang D, Qu C, Miao X, Zhang W, Zhang R, Liu G, Xiao P, Sun JP, Gong W | 10.1016/J.CELREP.2024.113893 | 2024-02-28 | Yes | |
| PF2R | FP | Prostanoid | A | Human | Cryo-EM | 8XJL | 8XJL_refined | 2.8 | R | Active | 100 | 80 | Gq/11 | αq | - | 58 | - | scFv16 |
PGF2α
|
small-molecule | Agonist | PGF2α, PGI2, PGE2, thromboxane A2, PGD2 | small-molecule | No | No | Li X, Zhang X, Wen X, Zhang D, Qu C, Miao X, Zhang W, Zhang R, Liu G, Xiao P, Sun JP, Gong W | 10.1016/J.CELREP.2024.113893 | 2024-02-28 | Yes | |
| PF2R | FP | Prostanoid | A | Human | Cryo-EM | 8XJK | 8XJK_refined | 2.6 | R | Active | 100 | 80 | Gq/11 | αq | - | 58 | - | scFv16 |
cloprostenol
|
small-molecule | Agonist | PGF2α, PGI2, PGE2, thromboxane A2, PGD2 | small-molecule | No | No | - | - | 2024-02-28 | Yes | |
| TA2R | TP | Prostanoid | A | Human | Cryo-EM | 8XJO | 8XJO_refined | 3.1 | R | Active | 100 | 90 | Gq/11 | αq | - | 58 | - | scFv16 |
U46619
|
small-molecule | Agonist | PGF2α, PGH2, PGI2, PGE2, thromboxane A2, PGD2 | small-molecule | No | No | Li X, Zhang X, Wen X, Zhang D, Qu C, Miao X, Zhang W, Zhang R, Liu G, Xiao P, Sun JP, Gong W | 10.1016/J.CELREP.2024.113893 | 2024-02-28 | Yes | |
| TA2R | TP | Prostanoid | A | Human | Cryo-EM | 8XJN | 8XJN_refined | 3.1 | R | Active | 100 | 90 | Gq/11 | αq | - | 58 | - | scFv16 |
cloprostenol
|
small-molecule | Agonist | PGF2α, PGH2, PGI2, PGE2, thromboxane A2, PGD2 | small-molecule | No | No | - | - | 2024-02-28 | Yes | |
| GP161 | GPR161 | A orphans | A | Human | Cryo-EM | 8SMV | 8SMV_refined | 2.7 | R | Active | 100 | 51 | Gs | αs | - | 61 | - | Nanobody-35 |
Apo (no ligand)
|
none | Apo (no ligand) | - | - | No | No | Hoppe N, Harrison S, Hwang SH, Chen Z, Karelina M, Deshpande I, Suomivuori CM, Palicharla VR, Berry SP, Tschaikner P, Regele D, Covey DF, Stefan E, Marks DS, Reiter J, Dror RO, Evers AS, Mukhopadhyay S, Manglik A | 10.1101/2023.05.23.540554 | 2024-02-21 | Yes | |
| AGRE5 | ADGRE5 | ADGRE | B2 | Human | Cryo-EM | 8IKJ | - | 3.2 | R | Inactive | 0 | 64 | - | - | - | - | BRIL | - |
Apo (no ligand)
|
none | Apo (no ligand) | - | - | No | No | Mao C, Zhao RJ, Dong YJ, Gao M, Chen LN, Zhang C, Xiao P, Guo J, Qin J, Shen DD, Ji SY, Zang SK, Zhang H, Wang WW, Shen Q, Sun JP, Zhang Y | 10.1016/J.MOLCEL.2023.12.020 | 2024-02-14 | Yes | |
| CNR1 | CB1 | Cannabinoid | A | Human | Cryo-EM | 8K8J | - | 2.9 | R | Active | 100 | 59 | Gs | αs | - | 61 | BRIL | Nanobody-35 |
FENOFIBRATE
|
small-molecule | Agonist | 2-arachidonoylglycerol, anandamide | small-molecule | No | No | Wang T, Tang W, Zhao Z, Zhao R, Lv Z, Guo X, Gu Q, Liu B, Lv H, Chen J, Zhang K, Li F, Wang J | 10.1002/ADVS.202306311 | 2024-02-14 | Yes | |
| GP156 | GPR156 | C Orphans | C | Human | Cryo-EM | 8IEP | - | 2.6 | C | Inactive | - | 34 | - | - | - | - | - | - |
[(2R)-3-[(E)-hexadec-9-enoyl]oxy-2-octadecanoyloxypropyl] 2-(trimethylazaniumyl)ethyl phosphate
|
lipid | Agonist | - | - | No | No | - | - | 2024-02-14 | Yes | |
| GP156 | GPR156 | C Orphans | C | Human | Cryo-EM | 8IED | - | 3.3 | A | Active | - | 33 | Gi/o | αo | - | 61 | - | - |
[(2R)-3-[(E)-hexadec-9-enoyl]oxy-2-octadecanoyloxypropyl] 2-(trimethylazaniumyl)ethyl phosphate
|
lipid | Agonist | - | - | No | No | - | - | 2024-02-14 | Yes | |
| GP156 | GPR156 | C Orphans | C | Human | Cryo-EM | 8IEB | - | 3.0 | A | Inactive | - | 33 | - | - | - | - | - | - |
[(2R)-3-[(E)-hexadec-9-enoyl]oxy-2-octadecanoyloxypropyl] 2-(trimethylazaniumyl)ethyl phosphate
|
lipid | Agonist | - | - | No | No | - | - | 2024-02-14 | Yes | |
| GP156 | GPR156 | C Orphans | C | Human | Cryo-EM | 8IEQ | - | 2.7 | A | Inactive | - | 34 | - | - | - | - | - | - |
[(2R)-3-[(E)-hexadec-9-enoyl]oxy-2-octadecanoyloxypropyl] 2-(trimethylazaniumyl)ethyl phosphate
|
lipid | Agonist | - | - | No | No | - | - | 2024-02-14 | Yes | |
| GP156 | GPR156 | C Orphans | C | Human | Cryo-EM | 8IEI | - | 2.6 | A | Inactive | - | 34 | - | - | - | - | - | - |
[(2R)-3-[(E)-hexadec-9-enoyl]oxy-2-octadecanoyloxypropyl] 2-(trimethylazaniumyl)ethyl phosphate
|
lipid | Agonist | - | - | No | No | - | - | 2024-02-14 | Yes | |
| GPR3 | GPR3 | A orphans | A | Human | Cryo-EM | 8WW2 | - | 2.8 | R | Active | 100 | 81 | Gs | αs | - | 58 | - | Nanobody-35 |
oleic acid
|
small-molecule | Agonist | sphingosine 1-phosphate | small-molecule | No | No | Xiong Y, Xu Z, Li X, Wang Y, Zhao J, Wang N, Duan Y, Xia R, Han Z, Qian Y, Liang J, Zhang A, Guo C, Inoue A, Xia Y, Chen Z, He Y | 10.1038/S41422-024-00932-5 | 2024-02-14 | Yes | |
| CASR | CaS | Calcium-sensing | C | Human | Cryo-EM | 8SZG | - | 3.6 | A | Active | - | 48 | Gq/11 | αq | - | 61 | - | - |
L-tryptophan
cinacalcet |
small-molecule small-molecule |
Agonist PAM |
Mg2+, L-tryptophan, spermine, Ca2+ | small-molecule | No | No | He F, Wu CG, Gao Y, Rahman SN, Zaoralova M, Papasergi-Scott MM, Gu TJ, Robertson MJ, Seven AB, Li L, Mathiesen JM, Skiniotis G | 10.1038/S41586-024-07055-2 | 2024-02-07 | Yes | |
| CASR | CaS | Calcium-sensing | C | Human | Cryo-EM | 8SZF | - | 2.8 | A | Active | - | 74 | - | - | - | - | - | - |
L-tryptophan
cinacalcet |
small-molecule small-molecule |
Agonist PAM |
Mg2+, L-tryptophan, spermine, Ca2+ | small-molecule | No | No | He F, Wu CG, Gao Y, Rahman SN, Zaoralova M, Papasergi-Scott MM, Gu TJ, Robertson MJ, Seven AB, Li L, Mathiesen JM, Skiniotis G | 10.1038/S41586-024-07055-2 | 2024-02-07 | Yes | |
| CASR | CaS | Calcium-sensing | C | Human | Cryo-EM | 8SZH | - | 3.1 | A | Active | - | 77 | Gi/o | αi3 | - | 63 | - | - |
L-tryptophan
cinacalcet |
small-molecule small-molecule |
Agonist PAM |
Mg2+, L-tryptophan, spermine, Ca2+ | small-molecule | No | No | He F, Wu CG, Gao Y, Rahman SN, Zaoralova M, Papasergi-Scott MM, Gu TJ, Robertson MJ, Seven AB, Li L, Mathiesen JM, Skiniotis G | 10.1038/S41586-024-07055-2 | 2024-02-07 | Yes | |
| CASR | CaS | Calcium-sensing | C | Human | Cryo-EM | 8SZI | - | 3.5 | A | Active | - | 57 | Gi/o | αi3 | - | 63 | - | - |
L-tryptophan
L-tryptophan |
small-molecule small-molecule |
Agonist PAM |
Mg2+, L-tryptophan, spermine, Ca2+ | small-molecule | No | No | He F, Wu CG, Gao Y, Rahman SN, Zaoralova M, Papasergi-Scott MM, Gu TJ, Robertson MJ, Seven AB, Li L, Mathiesen JM, Skiniotis G | 10.1038/S41586-024-07055-2 | 2024-02-07 | Yes | |
| CCR8 | CCR8 | Chemokine | A | Human | Cryo-EM | 8KFX | 8KFX_refined | 3.0 | R | Active | 100 | 81 | Gi/o | αi1 | - | 64 | - | scFv16 |
CHEMBL5268017
|
small-molecule | Agonist | CCL8, CCL1 | peptide | No | No | Jiang S, Lin X, Wu L, Wang L, Wu Y, Xu Z, Xu F | 10.1126/SCIADV.ADJ7500 | 2024-02-07 | Yes | |
| CCR8 | CCR8 | Chemokine | A | Human | Cryo-EM | 8KFY | 8KFY_refined | 3.1 | R | Active | 100 | 81 | Gi/o | αi1 | - | 64 | - | scFv16 |
ZK 756326
|
small-molecule | Agonist | CCL8, CCL1 | peptide | No | No | Jiang S, Lin X, Wu L, Wang L, Wu Y, Xu Z, Xu F | 10.1126/SCIADV.ADJ7500 | 2024-02-07 | Yes | |
| CCR8 | CCR8 | Chemokine | A | Human | Cryo-EM | 8KFZ | 8KFZ_refined | 3.3 | R | Active | 100 | 81 | Gi/o | αi1 | - | 64 | - | scFv16 |
Apo (no ligand)
|
none | Apo (no ligand) | CCL8, CCL1 | peptide | No | No | Jiang S, Lin X, Wu L, Wang L, Wu Y, Xu Z, Xu F | 10.1126/SCIADV.ADJ7500 | 2024-02-07 | Yes | |
| HCAR2 | HCA2 | Hydroxycarboxylic acid | A | Human | Cryo-EM | 8I7W | 8I7W_refined | 3.4 | A | Active | 100 | 80 | Gi/o | αi1 | - | 45 | - | scFv16 |
GSK256073
|
small-molecule | Agonist | butyric acid, β-D-hydroxybutyric acid | small-molecule | No | No | Park JH, Kawakami K, Ishimoto N, Ikuta T, Ohki M, Ekimoto T, Ikeguchi M, Lee DS, Lee YH, Tame JRH, Inoue A, Park SY | 10.1038/S41467-023-42764-8 | 2024-02-07 | Yes | |
| HCAR2 | HCA2 | Hydroxycarboxylic acid | A | Human | Cryo-EM | 8I7V | - | 2.8 | A | Active | 100 | 80 | Gi/o | αi1 | - | 41 | - | scFv16 |
5-Methyl-4-oxidanyl-pyrazin-4-ium-2-carboxylic acid
|
small-molecule | Agonist | butyric acid, β-D-hydroxybutyric acid | small-molecule | No | No | Park JH, Kawakami K, Ishimoto N, Ikuta T, Ohki M, Ekimoto T, Ikeguchi M, Lee DS, Lee YH, Tame JRH, Inoue A, Park SY | 10.1038/S41467-023-42764-8 | 2024-02-07 | Yes | |
| NK3R | NK3 | Tachykinin | A | Human | Cryo-EM | 8JBH | 8JBH_refined | 2.9 | B | Active | 100 | 59 | Gq/11 | αq | - | 59 | - | scFv16 |
Protachykinin-1
|
peptide | Agonist | neurokinin A, neurokinin B, substance P | peptide | No | No | - | - | 2024-02-07 | Yes | |
| NK3R | NK3 | Tachykinin | A | Human | Cryo-EM | 8JBG | 8JBG_refined | 2.8 | B | Active | 100 | 60 | Gq/11 | αq | - | 59 | - | scFv16 |
neurokinin B
|
peptide | Agonist | neurokinin A, neurokinin B, substance P | peptide | No | No | - | - | 2024-02-07 | Yes | |
| PF2R | FP | Prostanoid | A | Human | Cryo-EM | 8IQ6 | 8IQ6_refined | 3.4 | R | Active | 100 | 76 | Gs | αs | - | 51 | - | Nanobody-35 |
latanoprost (free acid form)
|
small-molecule | Agonist | PGF2α, PGI2, PGE2, thromboxane A2, PGD2 | small-molecule | No | No | Lv X, Gao K, Nie J, Zhang X, Zhang S, Ren Y, Sun X, Li Q, Huang J, Liu L, Zhang X, Zhang W, Liu X | 10.1038/S41467-023-43922-8 | 2024-01-31 | Yes | |
| PF2R | FP | Prostanoid | A | Human | Cryo-EM | 8IQ4 | 8IQ4_refined | 2.7 | R | Active | 100 | 76 | Gs | αs | - | 51 | - | Nanobody-35 |
Carboprost
|
small-molecule | Agonist | PGF2α, PGI2, PGE2, thromboxane A2, PGD2 | small-molecule | No | No | Lv X, Gao K, Nie J, Zhang X, Zhang S, Ren Y, Sun X, Li Q, Huang J, Liu L, Zhang X, Zhang W, Liu X | 10.1038/S41467-023-43922-8 | 2024-01-31 | Yes | |
| AGRE5 | ADGRE5 | ADGRE | B2 | Human | Cryo-EM | 8IKL | - | 2.3 | R | Active | 100 | 32 | G12/13 | α13 | - | 56 | - | - |
Apo (no ligand)
|
none | Apo (no ligand) | - | - | No | No | Mao C, Zhao RJ, Dong YJ, Gao M, Chen LN, Zhang C, Xiao P, Guo J, Qin J, Shen DD, Ji SY, Zang SK, Zhang H, Wang WW, Shen Q, Sun JP, Zhang Y | 10.1016/J.MOLCEL.2023.12.020 | 2024-01-24 | Yes | |
| FFAR1 | FFA1 | Free fatty acid | A | Human | Cryo-EM | 8T3V | - | 3.4 | R | Active | 100 | 92 | Gq/11 | αq | - | 59 | - | scFv16 |
docosahexaenoic acid
|
small-molecule | Agonist | myristic acid, oleic acid, docosahexaenoic acid, α-linolenic acid | small-molecule | No | No | Zhang X, Guseinov AA, Jenkins L, Li K, Tikhonova IG, Milligan G, Zhang C | 10.1126/SCIADV.ADJ2384 | 2024-01-24 | Yes | |
| FFAR2 | FFA2 | Free fatty acid | A | Human | Cryo-EM | 8J24 | 8J24_refined | 2.6 | D | Active | 100 | 78 | Gi/o | αi1 | - | 61 | - | scFv16 |
Acetic acid
|
small-molecule | Agonist | butyric acid, acetic acid, trans-2-methylcrotonic acid, propanoic acid | small-molecule | No | No | Li F, Tai L, Sun X, Lv Z, Tang W, Wang T, Zhao Z, Gong D, Ma S, Tang S, Gu Q, Zhu X, Yu M, Liu X, Wang J | 10.1038/S41422-023-00914-Z | 2024-01-24 | Yes | |
| FFAR2 | FFA2 | Free fatty acid | A | Human | Cryo-EM | 8J22 | 8J22_refined | 3.2 | C | Active | 100 | 86 | Gi/o | αi1 | - | 61 | - | scFv16 |
CHEMBL4176503
|
small-molecule | Agonist | butyric acid, acetic acid, trans-2-methylcrotonic acid, propanoic acid | small-molecule | No | No | Li F, Tai L, Sun X, Lv Z, Tang W, Wang T, Zhao Z, Gong D, Ma S, Tang S, Gu Q, Zhu X, Yu M, Liu X, Wang J | 10.1038/S41422-023-00914-Z | 2024-01-24 | Yes | |
| FFAR2 | FFA2 | Free fatty acid | A | Human | Cryo-EM | 8T3S | - | 3.1 | R | Active | 100 | 78 | Gq/11 | αq | - | 59 | - | scFv16 |
butyric acid
|
small-molecule | Agonist | butyric acid, acetic acid, trans-2-methylcrotonic acid, propanoic acid | small-molecule | No | No | Zhang X, Guseinov AA, Jenkins L, Li K, Tikhonova IG, Milligan G, Zhang C | 10.1126/SCIADV.ADJ2384 | 2024-01-24 | Yes | |
| FFAR3 | FFA3 | Free fatty acid | A | Human | Cryo-EM | 8J20 | - | 3.2 | D | Active | 100 | 79 | Gi/o | αi1 | - | 63 | - | scFv16 |
pentanoic acid
(4R)-N-[2,5-bis(chloranyl)phenyl]-4-(furan-2-yl)-2-methyl-5-oxidanylidene-4,6,7,8-tetrahydro-1H-quinoline-3-carboxamide |
small-molecule small-molecule |
Agonist PAM |
butyric acid, propanoic acid | small-molecule | No | No | Li F, Tai L, Sun X, Lv Z, Tang W, Wang T, Zhao Z, Gong D, Ma S, Tang S, Gu Q, Zhu X, Yu M, Liu X, Wang J | 10.1038/S41422-023-00914-Z | 2024-01-24 | Yes | |
| FFAR3 | FFA3 | Free fatty acid | A | Human | Cryo-EM | 8J21 | 8J21_refined | 3.3 | D | Active | 100 | 79 | Gi/o | αi1 | - | 63 | - | scFv16 |
butyric acid
|
small-molecule | Agonist | butyric acid, propanoic acid | small-molecule | No | No | Li F, Tai L, Sun X, Lv Z, Tang W, Wang T, Zhao Z, Gong D, Ma S, Tang S, Gu Q, Zhu X, Yu M, Liu X, Wang J | 10.1038/S41422-023-00914-Z | 2024-01-24 | Yes | |
| FFAR4 | FFA4 | Free fatty acid | A | Human | Cryo-EM | 8T3Q | 8T3Q_refined | 3.1 | R | Active | 100 | 83 | Gq/11 | αq | - | 59 | - | scFv16 |
docosahexaenoic acid
|
small-molecule | Agonist | oleic acid, myristic acid, linoleic acid, α-linolenic acid | small-molecule | No | No | Zhang X, Guseinov AA, Jenkins L, Li K, Tikhonova IG, Milligan G, Zhang C | 10.1126/SCIADV.ADJ2384 | 2024-01-24 | Yes | |
| AA2AR | A2A | Adenosine | A | Human | X-ray | 8WDT | - | 3.3 | A | Active | 69 | 72 | - | - | - | - | - | Fab heavy chain Fab light chain |
(2S,3S,4R,5R)-5-(6-amino-2-((E)-phenyldiazenyl)-9H-purin-9-yl)-N-ethyl-3,4-dihydroxytetrahydrofuran-2-carboxamide
|
small-molecule | Agonist | adenosine | small-molecule | No | No | Araya T, Matsuba Y, Suzuki H, Doura T, Nuemket N, Nango E, Yamamoto M, Im D, Asada H, Kiyonaka S, Iwata S | 10.1016/J.BBRC.2023.149393 | 2024-01-17 | Yes | |
| FFAR4 | FFA4 | Free fatty acid | A | Human | Cryo-EM | 8T3O | - | 3.1 | R | Active | 100 | 82 | Gq/11 | αq | - | 59 | - | scFv16 |
TUG-891
|
small-molecule | Agonist | oleic acid, myristic acid, linoleic acid, α-linolenic acid | small-molecule | No | No | Zhang X, Guseinov AA, Jenkins L, Li K, Tikhonova IG, Milligan G, Zhang C | 10.1126/SCIADV.ADJ2384 | 2024-01-17 | Yes | |
| FZD1 | FZD1 | Frizzled | F | Human | Cryo-EM | 8J9N | - | 3.5 | B | Active | 100 | 55 | Gq/11 | αq | Gq-Gs chimera | 60 | - | scFv16 |
Apo (no ligand)
|
none | Apo (no ligand) | Wnt-1, Wnt-3a, Wnt-7b, Wnt-5a, Wnt-2 | peptide | No | No | Zhang Z, Lin X, Wei L, Wu Y, Xu L, Wu L, Wei X, Zhao S, Zhu X, Xu F | 10.1038/S41421-023-00627-Y | 2024-01-17 | Yes | |
| FZD1 | FZD1 | Frizzled | F | Human | Cryo-EM | 8J9O | - | 3.4 | A | Active | 78 | 52 | - | - | - | - | BRIL | anti-Brill Fab Heavy chain anti-Fab Nanobody anti-Brill Fab Light chain |
Apo (no ligand)
|
none | Apo (no ligand) | Wnt-1, Wnt-3a, Wnt-7b, Wnt-5a, Wnt-2 | peptide | No | No | Zhang Z, Lin X, Wei L, Wu Y, Xu L, Wu L, Wei X, Zhao S, Zhu X, Xu F | 10.1038/S41421-023-00627-Y | 2024-01-17 | Yes | |
| FZD3 | FZD3 | Frizzled | F | Human | Cryo-EM | 8JHC | - | 3.3 | R | Active | 78 | 49 | - | - | - | - | BRIL | anti-Brill Fab Heavy chain anti-Fab Nanobody anti-Brill Fab Light chain |
Apo (no ligand)
|
none | Apo (no ligand) | - | - | No | No | Zhang Z, Lin X, Wei L, Wu Y, Xu L, Wu L, Wei X, Zhao S, Zhu X, Xu F | 10.1038/S41421-023-00627-Y | 2024-01-17 | Yes | |
| FZD3 | FZD3 | Frizzled | F | Human | Cryo-EM | 8JHI | - | 3.2 | R | Active | 100 | 48 | Gs | αs | - | 60 | - | Nanobody-35 |
Apo (no ligand)
|
none | Apo (no ligand) | - | - | No | No | - | - | 2024-01-17 | Yes | |
| FZD6 | FZD6 | Frizzled | F | Human | Cryo-EM | 8JH7 | - | 3.2 | D | Active | 78 | 46 | - | - | - | - | BRIL | anti-Brill Fab Heavy chain anti-Fab Nanobody anti-Brill Fab Light chain |
Apo (no ligand)
|
none | Apo (no ligand) | Wnt-5a, Wnt-3a, Wnt-4 | peptide | No | No | Zhang Z, Lin X, Wei L, Wu Y, Xu L, Wu L, Wei X, Zhao S, Zhu X, Xu F | 10.1038/S41421-023-00627-Y | 2024-01-17 | Yes | |
| FZD6 | FZD6 | Frizzled | F | Human | Cryo-EM | 8JHB | - | 3.3 | R | Active | 100 | 47 | Gs | αs | - | 61 | - | Nanobody-35 |
Apo (no ligand)
|
none | Apo (no ligand) | Wnt-5a, Wnt-3a, Wnt-4 | peptide | No | No | Zhang Z, Lin X, Wei L, Wu Y, Xu L, Wu L, Wei X, Zhao S, Zhu X, Xu F | 10.1038/S41421-023-00627-Y | 2024-01-17 | Yes | |
| HRH1 | H1 | Histamine | A | Human | Cryo-EM | 8X64 | - | 3.4 | B | Inactive | 3 | 53 | - | - | - | - | BRIL | - |
desloratadine
|
small-molecule | Antagonist | histamine | small-molecule | No | No | Wang D, Guo Q, Wu Z, Li M, He B, Du Y, Zhang K, Tao Y | 10.1038/S41467-023-44477-4 | 2024-01-17 | Yes | |
| HRH1 | H1 | Histamine | A | Human | Cryo-EM | 8X63 | - | 3.2 | B | Inactive | 3 | 55 | - | - | - | - | BRIL | - |
mepyramine
|
small-molecule | Antagonist | histamine | small-molecule | No | No | Wang D, Guo Q, Wu Z, Li M, He B, Du Y, Zhang K, Tao Y | 10.1038/S41467-023-44477-4 | 2024-01-17 | Yes | |
| HRH1 | H1 | Histamine | A | Human | Cryo-EM | 8X5X | - | 3.5 | B | Inactive | 3 | 52 | - | - | - | - | BRIL | - |
Apo (no ligand)
|
none | Apo (no ligand) | histamine | small-molecule | No | No | Wang D, Guo Q, Wu Z, Li M, He B, Du Y, Zhang K, Tao Y | 10.1038/S41467-023-44477-4 | 2024-01-17 | Yes | |
| HRH1 | H1 | Histamine | A | Human | Cryo-EM | 8X5Y | - | 3.0 | B | Inactive | 3 | 55 | - | - | - | - | BRIL | - |
astemizole
|
small-molecule | Antagonist | histamine | small-molecule | No | No | Wang D, Guo Q, Wu Z, Li M, He B, Du Y, Zhang K, Tao Y | 10.1038/S41467-023-44477-4 | 2024-01-17 | Yes | |
| HCAR2 | HCA2 | Hydroxycarboxylic acid | A | Human | Cryo-EM | 8J6J | 8J6J_refined | 2.8 | R | Active | 100 | 85 | Gi/o | αi1 | - | 61 | - | scFv16 |
GSK256073
|
small-molecule | Agonist | butyric acid, β-D-hydroxybutyric acid | small-molecule | No | No | Zhu S, Yuan Q, Li X, He X, Shen S, Wang D, Li J, Cheng X, Duan X, Xu HE, Duan J | 10.1016/J.CELREP.2023.113406 | 2024-01-10 | Yes | |
| MRGX1 | MRGPRX1 | A orphans | A | Human | Cryo-EM | 8JGG | 8JGG_refined | 3.0 | R | Active | 100 | 69 | Gi/o | αi1 | - | 61 | - | scFv16 |
bovine adrenal medulla peptide 8-22
|
peptide | Agonist | bovine adrenal medulla peptide 8-22 | peptide | No | No | Guo L, Zhang Y, Fang G, Tie L, Zhuang Y, Xue C, Liu Q, Zhang M, Zhu K, You C, Xu P, Yuan Q, Zhang C, Liu L, Rong N, Peng S, Liu Y, Wang C, Luo X, Lv Z, Kang D, Yu X, Zhang C, Jiang Y, Dong X, Zhou J, Liu Z, Yang F, Eric Xu H, Sun JP | 10.1038/S41467-023-40705-Z | 2024-01-10 | Yes | |
| MRGX1 | MRGPRX1 | A orphans | A | Human | Cryo-EM | 8JGF | 8JGF_refined | 2.7 | R | Active | 100 | 73 | Gq/11 | αq | - | 60 | - | scFv16 |
bovine adrenal medulla peptide 8-22
|
peptide | Agonist | bovine adrenal medulla peptide 8-22 | peptide | No | No | Guo L, Zhang Y, Fang G, Tie L, Zhuang Y, Xue C, Liu Q, Zhang M, Zhu K, You C, Xu P, Yuan Q, Zhang C, Liu L, Rong N, Peng S, Liu Y, Wang C, Luo X, Lv Z, Kang D, Yu X, Zhang C, Jiang Y, Dong X, Zhou J, Liu Z, Yang F, Eric Xu H, Sun JP | 10.1038/S41467-023-40705-Z | 2024-01-10 | Yes | |
| MRGX1 | MRGPRX1 | A orphans | A | Human | Cryo-EM | 8JGB | 8JGB_refined | 2.8 | R | Active | 100 | 67 | Gi/o | αi1 | - | 61 | - | scFv16 |
Conorfamide-Tx2
|
protein | Agonist | bovine adrenal medulla peptide 8-22 | peptide | No | No | Guo L, Zhang Y, Fang G, Tie L, Zhuang Y, Xue C, Liu Q, Zhang M, Zhu K, You C, Xu P, Yuan Q, Zhang C, Liu L, Rong N, Peng S, Liu Y, Wang C, Luo X, Lv Z, Kang D, Yu X, Zhang C, Jiang Y, Dong X, Zhou J, Liu Z, Yang F, Eric Xu H, Sun JP | 10.1038/S41467-023-40705-Z | 2024-01-10 | Yes | |
| PE2R3 | EP3 | Prostanoid | A | Human | Cryo-EM | 8GDC | 8GDC_refined | 3.5 | R | Active | 100 | 66 | Gi/o | αi1 | - | 58 | - | - |
PGE2
|
small-molecule | Agonist | PGE1, PGF2α, PGI2, PGE2, thromboxane A2, PGD2 | small-molecule | No | No | Huang SM, Xiong MY, Liu L, Mu J, Wang MW, Jia YL, Cai K, Tie L, Zhang C, Cao S, Wen X, Wang JL, Guo SC, Li Y, Qu CX, He QT, Cai BY, Xue C, Gan S, Xie Y, Cong X, Yang Z, Kong W, Li S, Li Z, Xiao P, Yang F, Yu X, Guan YF, Zhang X, Liu Z, Yang BX, Du Y, Sun JP | 10.1073/PNAS.2216329120 | 2024-01-10 | Yes | |
| PE2R4 | EP4 | Prostanoid | A | Human | Cryo-EM | 8GDA | 8GDA_refined | 3.3 | R | Active | 100 | 58 | Gs | αs | - | 58 | - | - |
(2S,5R)-5-[(1E,3S)-4,4-difluoro-3-hydroxy-4-phenylbut-1-en-1-yl]-1-[6-(1H-tetrazol-5-yl)hexyl]pyrrolidin-2-ol
|
small-molecule | Agonist | PGE1, PGF2α, PGI2, PGE2, thromboxane A2, PGD2 | small-molecule | No | No | Huang SM, Xiong MY, Liu L, Mu J, Wang MW, Jia YL, Cai K, Tie L, Zhang C, Cao S, Wen X, Wang JL, Guo SC, Li Y, Qu CX, He QT, Cai BY, Xue C, Gan S, Xie Y, Cong X, Yang Z, Kong W, Li S, Li Z, Xiao P, Yang F, Yu X, Guan YF, Zhang X, Liu Z, Yang BX, Du Y, Sun JP | 10.1073/PNAS.2216329120 | 2024-01-10 | Yes | |
| PE2R4 | EP4 | Prostanoid | A | Human | Cryo-EM | 8GD9 | - | 3.2 | R | Active | 100 | 57 | Gs | αs | - | 54 | - | - |
4-({2-[(1R,2R,3R,5S)-3,5-dihydroxy-2-{(3S)-3-hydroxy-4-[3-(methoxymethyl)phenyl]butyl}cyclopentyl]ethyl}sulfanyl)butanoic acid
|
small-molecule | Agonist | PGE1, PGF2α, PGI2, PGE2, thromboxane A2, PGD2 | small-molecule | No | No | Huang SM, Xiong MY, Liu L, Mu J, Wang MW, Jia YL, Cai K, Tie L, Zhang C, Cao S, Wen X, Wang JL, Guo SC, Li Y, Qu CX, He QT, Cai BY, Xue C, Gan S, Xie Y, Cong X, Yang Z, Kong W, Li S, Li Z, Xiao P, Yang F, Yu X, Guan YF, Zhang X, Liu Z, Yang BX, Du Y, Sun JP | 10.1073/PNAS.2216329120 | 2024-01-10 | Yes | |
| PE2R4 | EP4 | Prostanoid | A | Human | Cryo-EM | 8GDB | 8GDB_refined | 3.1 | R | Active | 100 | 58 | Gs | αs | - | 59 | - | - |
PGE2
|
small-molecule | Agonist | PGE1, PGF2α, PGI2, PGE2, thromboxane A2, PGD2 | small-molecule | No | No | Huang SM, Xiong MY, Liu L, Mu J, Wang MW, Jia YL, Cai K, Tie L, Zhang C, Cao S, Wen X, Wang JL, Guo SC, Li Y, Qu CX, He QT, Cai BY, Xue C, Gan S, Xie Y, Cong X, Yang Z, Kong W, Li S, Li Z, Xiao P, Yang F, Yu X, Guan YF, Zhang X, Liu Z, Yang BX, Du Y, Sun JP | 10.1073/PNAS.2216329120 | 2024-01-10 | Yes | |
| TAAR1 | TA1 | Trace amine | A | Human | Cryo-EM | 8UHB | 8UHB_refined | 3.4 | A | Active | 100 | 93 | Gs | αs | - | 60 | BRIL | Nanobody-35 |
CHEMBL3684869
|
small-molecule | Agonist | tyramine, (+)-Octopamine, octopamine, β-phenylethylamine, CHEMBL1160703, 3-iodothyronamine, dopamine | small-molecule | No | No | Zilberg G, Parpounas AK, Warren AL, Yang S, Wacker D | 10.1038/S41467-023-44601-4 | 2024-01-10 | Yes | |
| GP101 | GPR101 | A orphans | A | Human | Cryo-EM | 8W8S | - | 3.3 | R | Active | 94 | 55 | - | - | - | - | - | - |
1-(4-Methylpyridin-2-yl)-3-[3-(trifluoromethyl)phenyl]thiourea
|
small-molecule | Agonist | - | - | No | No | Yang Z, Wang JY, Yang F, Zhu KK, Wang GP, Guan Y, Ning SL, Lu Y, Li Y, Zhang C, Zheng Y, Zhou SH, Wang XW, Wang MW, Xiao P, Yi F, Zhang C, Zhang PJ, Xu F, Liu BH, Zhang H, Yu X, Gao N, Sun JP | 10.1038/S41589-023-01456-6 | 2024-01-03 | Yes | |
| GP101 | GPR101 | A orphans | A | Human | Cryo-EM | 8W8Q | 8W8Q_refined | 2.9 | C | Active | 100 | 56 | Gs | αs | - | 59 | BRIL | Nanobody-35 |
Apo (no ligand)
|
none | Apo (no ligand) | - | - | No | No | Yang Z, Wang JY, Yang F, Zhu KK, Wang GP, Guan Y, Ning SL, Lu Y, Li Y, Zhang C, Zheng Y, Zhou SH, Wang XW, Wang MW, Xiao P, Yi F, Zhang C, Zhang PJ, Xu F, Liu BH, Zhang H, Yu X, Gao N, Sun JP | 10.1038/S41589-023-01456-6 | 2024-01-03 | Yes | |
| GP101 | GPR101 | A orphans | A | Human | Cryo-EM | 8W8R | - | 3.3 | R | Active | 100 | 55 | Gs | αs | - | 60 | - | scFv16 |
1-(4-Methylpyridin-2-yl)-3-[3-(trifluoromethyl)phenyl]thiourea
|
small-molecule | Agonist | - | - | No | No | Yang Z, Wang JY, Yang F, Zhu KK, Wang GP, Guan Y, Ning SL, Lu Y, Li Y, Zhang C, Zheng Y, Zhou SH, Wang XW, Wang MW, Xiao P, Yi F, Zhang C, Zhang PJ, Xu F, Liu BH, Zhang H, Yu X, Gao N, Sun JP | 10.1038/S41589-023-01456-6 | 2024-01-03 | Yes | |
| HCAR2 | HCA2 | Hydroxycarboxylic acid | A | Human | Cryo-EM | 8IJD | - | 3.3 | A | Active | 100 | 81 | Gi/o | αi1 | - | 61 | - | scFv16 |
MK 6892
|
small-molecule | Agonist | butyric acid, β-D-hydroxybutyric acid | small-molecule | No | No | Pan X, Ye F, Ning P, Zhang Z, Li X, Zhang B, Wang Q, Chen G, Gao W, Qiu C, Wu Z, Li J, Zhu L, Xia J, Gong K, Du Y | 10.1038/S41421-023-00610-7 | 2024-01-03 | Yes | |
| HCAR2 | HCA2 | Hydroxycarboxylic acid | A | Human | Cryo-EM | 8IJB | 8IJB_refined | 3.2 | A | Active | 100 | 81 | Gi/o | αi1 | - | 61 | - | scFv16 |
5-Methyl-4-oxidanyl-pyrazin-4-ium-2-carboxylic acid
|
small-molecule | Agonist | butyric acid, β-D-hydroxybutyric acid | small-molecule | No | No | Pan X, Ye F, Ning P, Zhang Z, Li X, Zhang B, Wang Q, Chen G, Gao W, Qiu C, Wu Z, Li J, Zhu L, Xia J, Gong K, Du Y | 10.1038/S41421-023-00610-7 | 2024-01-03 | Yes | |
| HCAR2 | HCA2 | Hydroxycarboxylic acid | A | Human | Cryo-EM | 8IJA | - | 2.7 | A | Active | 100 | 81 | Gi/o | αi1 | - | 61 | - | scFv16 |
nicotinic acid
|
small-molecule | Agonist | butyric acid, β-D-hydroxybutyric acid | small-molecule | No | No | Pan X, Ye F, Ning P, Zhang Z, Li X, Zhang B, Wang Q, Chen G, Gao W, Qiu C, Wu Z, Li J, Zhu L, Xia J, Gong K, Du Y | 10.1038/S41421-023-00610-7 | 2024-01-03 | Yes | |
| HCAR2 | HCA2 | Hydroxycarboxylic acid | A | Human | Cryo-EM | 8IJ3 | 8IJ3_refined | 3.3 | A | Active | 100 | 80 | Gi/o | αi1 | - | 61 | - | scFv16 |
Apo (no ligand)
|
none | Apo (no ligand) | butyric acid, β-D-hydroxybutyric acid | small-molecule | No | No | Pan X, Ye F, Ning P, Zhang Z, Li X, Zhang B, Wang Q, Chen G, Gao W, Qiu C, Wu Z, Li J, Zhu L, Xia J, Gong K, Du Y | 10.1038/S41421-023-00610-7 | 2024-01-03 | Yes | |
| PE2R4 | EP4 | Prostanoid | A | Human | Cryo-EM | 8GCM | - | 3.5 | R | Active | 100 | 52 | Gi/o | αi1 | - | 56 | - | scFv16 |
(5S)-5-[(3R)-4,4-difluoro-3-hydroxy-4-phenylbutyl]-1-[6-(1H-tetrazol-5-yl)hexyl]pyrrolidin-2-one
|
lipid | Agonist | PGE1, PGF2α, PGI2, PGE2, thromboxane A2, PGD2 | small-molecule | No | No | Huang SM, Xiong MY, Liu L, Mu J, Wang MW, Jia YL, Cai K, Tie L, Zhang C, Cao S, Wen X, Wang JL, Guo SC, Li Y, Qu CX, He QT, Cai BY, Xue C, Gan S, Xie Y, Cong X, Yang Z, Kong W, Li S, Li Z, Xiao P, Yang F, Yu X, Guan YF, Zhang X, Liu Z, Yang BX, Du Y, Sun JP | 10.1073/PNAS.2216329120 | 2024-01-03 | Yes | |
| PE2R4 | EP4 | Prostanoid | A | Human | Cryo-EM | 8GCP | 8GCP_refined | 3.1 | R | Active | 100 | 56 | Gi/o | αi1 | - | 61 | - | scFv16 |
PGE2
|
small-molecule | Agonist | PGE1, PGF2α, PGI2, PGE2, thromboxane A2, PGD2 | small-molecule | No | No | Huang SM, Xiong MY, Liu L, Mu J, Wang MW, Jia YL, Cai K, Tie L, Zhang C, Cao S, Wen X, Wang JL, Guo SC, Li Y, Qu CX, He QT, Cai BY, Xue C, Gan S, Xie Y, Cong X, Yang Z, Kong W, Li S, Li Z, Xiao P, Yang F, Yu X, Guan YF, Zhang X, Liu Z, Yang BX, Du Y, Sun JP | 10.1073/PNAS.2216329120 | 2024-01-03 | Yes | |
| GPR21 | GPR21 | A orphans | A | Human | Cryo-EM | 8HJ1 | 8HJ1_refined | 3.3 | R | Active | 100 | 81 | Gs | αs | - | 61 | - | Nanobody-35 |
Apo (no ligand)
|
none | Apo (no ligand) | - | - | No | No | Lin X, Chen B, Wu Y, Han Y, Qi A, Wang J, Yang Z, Wei X, Zhao T, Wu L, Xie X, Sun J, Zheng J, Zhao S, Xu F | 10.1038/S41467-023-35882-W | 2023-12-27 | Yes | |
| GPR34 | GPR34 | A orphans | A | Human | Cryo-EM | 8XBH | 8XBH_refined | 2.8 | R | Active | 100 | 78 | Gi/o | αi1 | - | 62 | - | scFv16 |
CHEMBL4758243
|
small-molecule | Agonist | lysophosphatidylserine | small-molecule | No | No | - | - | 2023-12-27 | Yes | |
| GPR34 | GPR34 | A orphans | A | Human | Cryo-EM | 8XBI | - | 3.1 | R | Active | 60 | 78 | - | - | - | - | - | - |
CHEMBL4758243
|
small-molecule | Agonist | lysophosphatidylserine | small-molecule | No | No | - | - | 2023-12-27 | Yes | |
| OPRM | μ | Opioid | A | Mouse | Cryo-EM | 8QOT | - | 3.2 | A | Inactive | 8 | 72 | - | - | - | - | - | Nanobody-E NabFab HC NabFab LC anti-Fab Nanobody |
Nanobody-E
|
protein | Antagonist | - | - | No | No | Yu J, Kumar A, Zhang X, Martin C, Raia P, Koehl A, Laeremans T, Steyaert J, Manglik A, Ballet S, Boland A, Stoeber M | 10.1101/2023.12.06.570395 | 2023-12-27 | Yes | |
| TAAR1 | TA1 | Trace amine | A | Human | Cryo-EM | 8WCA | - | 3.5 | R | Active | 100 | 81 | Gs | αs | - | 59 | - | scFv16 |
2-Phenylethanaminium
|
small-molecule | Agonist | tyramine, (+)-Octopamine, octopamine, β-phenylethylamine, CHEMBL1160703, 3-iodothyronamine, dopamine | small-molecule | No | No | Shang P, Rong N, Jiang JJ, Cheng J, Zhang MH, Kang D, Qi L, Guo L, Yang GM, Liu Q, Zhou Z, Li XB, Zhu KK, Meng QB, Han X, Yan W, Kong Y, Yang L, Wang X, Lei D, Feng X, Liu X, Yu X, Wang Y, Li Q, Shao ZH, Yang F, Sun JP | 10.1016/J.CELL.2023.10.014 | 2023-12-27 | Yes | |
| TAAR1 | TA1 | Trace amine | A | Mouse | Cryo-EM | 8WCB | - | 3.1 | R | Active | 100 | 75 | Gq/11 | αq | - | 57 | - | scFv16 |
Cyclohexylammonium ion
|
small-molecule | Agonist | tyramine, β-phenylethylamine, 3-iodothyronamine | small-molecule | No | No | Shang P, Rong N, Jiang JJ, Cheng J, Zhang MH, Kang D, Qi L, Guo L, Yang GM, Liu Q, Zhou Z, Li XB, Zhu KK, Meng QB, Han X, Yan W, Kong Y, Yang L, Wang X, Lei D, Feng X, Liu X, Yu X, Wang Y, Li Q, Shao ZH, Yang F, Sun JP | 10.1016/J.CELL.2023.10.014 | 2023-12-27 | Yes | |
| TAAR1 | TA1 | Trace amine | A | Mouse | Cryo-EM | 8WCC | - | 3.0 | R | Active | 96 | 81 | - | - | - | - | - | - |
Cyclohexylammonium ion
|
small-molecule | Agonist | tyramine, β-phenylethylamine, 3-iodothyronamine | small-molecule | No | No | Shang P, Rong N, Jiang JJ, Cheng J, Zhang MH, Kang D, Qi L, Guo L, Yang GM, Liu Q, Zhou Z, Li XB, Zhu KK, Meng QB, Han X, Yan W, Kong Y, Yang L, Wang X, Lei D, Feng X, Liu X, Yu X, Wang Y, Li Q, Shao ZH, Yang F, Sun JP | 10.1016/J.CELL.2023.10.014 | 2023-12-27 | Yes | |
| TAAR1 | TA1 | Trace amine | A | Mouse | Cryo-EM | 8WC4 | - | 3.1 | R | Active | 100 | 82 | Gs | αs | - | 59 | - | scFv16 |
CHEMBL476516
|
small-molecule | Agonist | tyramine, β-phenylethylamine, 3-iodothyronamine | small-molecule | No | No | Shang P, Rong N, Jiang JJ, Cheng J, Zhang MH, Kang D, Qi L, Guo L, Yang GM, Liu Q, Zhou Z, Li XB, Zhu KK, Meng QB, Han X, Yan W, Kong Y, Yang L, Wang X, Lei D, Feng X, Liu X, Yu X, Wang Y, Li Q, Shao ZH, Yang F, Sun JP | 10.1016/J.CELL.2023.10.014 | 2023-12-27 | Yes | |
| TAAR1 | TA1 | Trace amine | A | Mouse | Cryo-EM | 8WC3 | - | 3.0 | R | Active | 100 | 80 | Gs | αs | - | 59 | - | scFv16 |
ulotaront
|
small-molecule | Agonist | tyramine, β-phenylethylamine, 3-iodothyronamine | small-molecule | No | No | Shang P, Rong N, Jiang JJ, Cheng J, Zhang MH, Kang D, Qi L, Guo L, Yang GM, Liu Q, Zhou Z, Li XB, Zhu KK, Meng QB, Han X, Yan W, Kong Y, Yang L, Wang X, Lei D, Feng X, Liu X, Yu X, Wang Y, Li Q, Shao ZH, Yang F, Sun JP | 10.1016/J.CELL.2023.10.014 | 2023-12-27 | Yes | |
| TAAR1 | TA1 | Trace amine | A | Mouse | Cryo-EM | 8WC9 | - | 3.2 | R | Active | 100 | 79 | Gq/11 | αq | - | 58 | - | scFv16 |
CHEMBL476516
|
small-molecule | Agonist | tyramine, β-phenylethylamine, 3-iodothyronamine | small-molecule | No | No | Shang P, Rong N, Jiang JJ, Cheng J, Zhang MH, Kang D, Qi L, Guo L, Yang GM, Liu Q, Zhou Z, Li XB, Zhu KK, Meng QB, Han X, Yan W, Kong Y, Yang L, Wang X, Lei D, Feng X, Liu X, Yu X, Wang Y, Li Q, Shao ZH, Yang F, Sun JP | 10.1016/J.CELL.2023.10.014 | 2023-12-27 | Yes | |
| TAAR1 | TA1 | Trace amine | A | Mouse | Cryo-EM | 8WC7 | - | 3.1 | R | Active | 100 | 81 | Gs | αs | - | 58 | - | scFv16 |
2-[4-(3-Fluorophenyl)phenyl]ethan-1-amine
|
small-molecule | Agonist | tyramine, β-phenylethylamine, 3-iodothyronamine | small-molecule | No | No | Shang P, Rong N, Jiang JJ, Cheng J, Zhang MH, Kang D, Qi L, Guo L, Yang GM, Liu Q, Zhou Z, Li XB, Zhu KK, Meng QB, Han X, Yan W, Kong Y, Yang L, Wang X, Lei D, Feng X, Liu X, Yu X, Wang Y, Li Q, Shao ZH, Yang F, Sun JP | 10.1016/J.CELL.2023.10.014 | 2023-12-27 | Yes | |
| TAAR1 | TA1 | Trace amine | A | Human | Cryo-EM | 8WC8 | - | 2.9 | R | Active | 100 | 81 | Gs | αs | - | 56 | - | scFv16 |
CHEMBL476516
|
small-molecule | Agonist | tyramine, (+)-Octopamine, octopamine, β-phenylethylamine, CHEMBL1160703, 3-iodothyronamine, dopamine | small-molecule | No | No | Shang P, Rong N, Jiang JJ, Cheng J, Zhang MH, Kang D, Qi L, Guo L, Yang GM, Liu Q, Zhou Z, Li XB, Zhu KK, Meng QB, Han X, Yan W, Kong Y, Yang L, Wang X, Lei D, Feng X, Liu X, Yu X, Wang Y, Li Q, Shao ZH, Yang F, Sun JP | 10.1016/J.CELL.2023.10.014 | 2023-12-27 | Yes | |
| TAAR1 | TA1 | Trace amine | A | Mouse | Cryo-EM | 8WC5 | - | 3.3 | R | Active | 100 | 78 | Gs | αs | - | 58 | - | scFv16 |
Tetramethylammonium
|
small-molecule | Agonist | tyramine, β-phenylethylamine, 3-iodothyronamine | small-molecule | No | No | Shang P, Rong N, Jiang JJ, Cheng J, Zhang MH, Kang D, Qi L, Guo L, Yang GM, Liu Q, Zhou Z, Li XB, Zhu KK, Meng QB, Han X, Yan W, Kong Y, Yang L, Wang X, Lei D, Feng X, Liu X, Yu X, Wang Y, Li Q, Shao ZH, Yang F, Sun JP | 10.1016/J.CELL.2023.10.014 | 2023-12-27 | Yes | |
| TAAR1 | TA1 | Trace amine | A | Mouse | Cryo-EM | 8WC6 | - | 3.2 | R | Active | 100 | 80 | Gs | αs | - | 58 | - | scFv16 Nanobody-35 |
2-Phenylethanaminium
|
small-molecule | Agonist | tyramine, β-phenylethylamine, 3-iodothyronamine | small-molecule | No | No | Shang P, Rong N, Jiang JJ, Cheng J, Zhang MH, Kang D, Qi L, Guo L, Yang GM, Liu Q, Zhou Z, Li XB, Zhu KK, Meng QB, Han X, Yan W, Kong Y, Yang L, Wang X, Lei D, Feng X, Liu X, Yu X, Wang Y, Li Q, Shao ZH, Yang F, Sun JP | 10.1016/J.CELL.2023.10.014 | 2023-12-27 | Yes | |
| ADA1A | α1A | Adrenoceptors | A | Human | Cryo-EM | 8HN1 | - | 2.9 | A | Inactive | 3 | 57 | - | - | - | - | - | Nanobody-6 |
ρ-Da1a
|
peptide | Antagonist | (-)-adrenaline, (-)-noradrenaline | small-molecule | No | No | - | - | 2023-12-20 | Yes | |
| CCR8 | CCR8 | Chemokine | A | Human | Cryo-EM | 8TLM | - | 2.9 | C | Inactive | 9 | 75 | - | - | - | - | - | Fab heavy chain Fab light chain |
mAb1
|
protein | Antagonist | CCL8, CCL1 | peptide | No | No | Sun D, Sun Y, Janezic E, Zhou T, Johnson M, Azumaya C, Noreng S, Chiu C, Seki A, Arenzana TL, Nicoludis JM, Shi Y, Wang B, Ho H, Joshi P, Tam C, Payandeh J, Comps-Agrar L, Wang J, Rutz S, Koerber JT, Masureel M | 10.1038/S41467-023-43601-8 | 2023-12-20 | Yes | |
| CCR8 | CCR8 | Chemokine | A | Human | Cryo-EM | 8U1U | - | 3.1 | A | Active | 100 | 83 | Gi/o | αi1 | - | 60 | - | scFv16 |
CCL1
|
protein | Agonist | CCL8, CCL1 | peptide | No | No | - | - | 2023-12-20 | Yes | |
| HRH4 | H4 | Histamine | A | Human | Cryo-EM | 8HOC | - | 3.0 | R | Active | 100 | 71 | Gi/o | αi1 | - | 64 | - | scFv16 |
imetit
|
small-molecule | Agonist | histamine, CCL16 | small-molecule | No | No | - | - | 2023-12-20 | Yes | |
| HRH4 | H4 | Histamine | A | Human | Cryo-EM | 8HN8 | - | 3.0 | R | Active | 100 | 71 | Gi/o | αi1 | - | 62 | - | scFv16 |
histamine
|
small-molecule | Agonist | histamine, CCL16 | small-molecule | No | No | - | - | 2023-12-20 | Yes | |
| O52E4 | OR52E4 | Odorant family 52 | O1 | Human | Cryo-EM | 8W77 | - | 3.6 | A | Inactive | - | 83 | - | - | - | - | BRIL | - |
Apo (no ligand)
|
none | Apo (no ligand) | - | - | No | No | Choi C, Bae J, Kim S, Lee S, Kang H, Kim J, Bang I, Kim K, Huh WK, Seok C, Park H, Im W, Choi HJ | 10.1038/S41467-023-43983-9 | 2023-12-20 | Yes | |
| O52E4 | OR52E4 | Odorant family 52 | O1 | Human | Cryo-EM | 8HTI | - | 3.0 | R | Active | - | 97 | Gs | αs | - | 40 | - | Nanobody-35 |
OCTANOIC ACID
|
small-molecule | Agonist | - | - | No | No | Choi C, Bae J, Kim S, Lee S, Kang H, Kim J, Bang I, Kim K, Huh WK, Seok C, Park H, Im W, Choi HJ | 10.1038/S41467-023-43983-9 | 2023-12-20 | Yes | |
| O52E4 | OR52E4 | Odorant family 52 | O1 | Human | Cryo-EM | 8J46 | - | 3.7 | A | Active | - | 83 | - | - | - | - | BRIL | - |
Apo (no ligand)
|
none | Apo (no ligand) | - | - | No | No | Choi C, Bae J, Kim S, Lee S, Kang H, Kim J, Bang I, Kim K, Huh WK, Seok C, Park H, Im W, Choi HJ | 10.1038/S41467-023-43983-9 | 2023-12-20 | Yes | |
| GASR | CCK2 | Cholecystokinin | A | Human | Cryo-EM | 8IA7 | 8IA7_refined | 3.1 | R | Active | 100 | 62 | Gq/11 | αq | - | 61 | - | - |
CHEMBL216166
|
protein | Agonist | CCK-39, desulfated gastrin-14, gastrin-71, desulfated gastrin-71, desulfated gastrin-17, gastrin-17, desulfated gastrin-34, desulfated cholecystokinin-8, gastrin-14, CCK-4, CCK-58, gastrin-34, CCK-8, CCK-33 | peptide | No | No | Ding Y, Zhang H, Liao YY, Chen LN, Ji SY, Qin J, Mao C, Shen DD, Lin L, Wang H, Zhang Y, Li XM | 10.1038/S41421-022-00420-3 | 2023-12-06 | Yes | |
| HCAR2 | HCA2 | Hydroxycarboxylic acid | A | Human | Cryo-EM | 8J6R | - | 2.8 | R | Active | 100 | 81 | Gi/o | αi1 | - | 64 | - | scFv16 |
MK 6892
|
small-molecule | Agonist | butyric acid, β-D-hydroxybutyric acid | small-molecule | No | No | Mao C, Gao M, Zang SK, Zhu Y, Shen DD, Chen LN, Yang L, Wang Z, Zhang H, Wang WW, Shen Q, Lu Y, Ma X, Zhang Y | 10.1038/S41467-023-43537-Z | 2023-12-06 | Yes | |
| HCAR2 | HCA2 | Hydroxycarboxylic acid | A | Human | Cryo-EM | 8J6Q | - | 2.6 | R | Active | 100 | 81 | Gi/o | αi1 | - | 64 | - | scFv16 |
β-D-hydroxybutyric acid
|
small-molecule | Agonist | butyric acid, β-D-hydroxybutyric acid | small-molecule | No | No | Mao C, Gao M, Zang SK, Zhu Y, Shen DD, Chen LN, Yang L, Wang Z, Zhang H, Wang WW, Shen Q, Lu Y, Ma X, Zhang Y | 10.1038/S41467-023-43537-Z | 2023-12-06 | Yes | |
| HCAR2 | HCA2 | Hydroxycarboxylic acid | A | Human | Cryo-EM | 8J6P | - | 2.6 | R | Active | 100 | 81 | Gi/o | αi1 | - | 64 | - | scFv16 |
nicotinic acid
|
small-molecule | Agonist | butyric acid, β-D-hydroxybutyric acid | small-molecule | No | No | Mao C, Gao M, Zang SK, Zhu Y, Shen DD, Chen LN, Yang L, Wang Z, Zhang H, Wang WW, Shen Q, Lu Y, Ma X, Zhang Y | 10.1038/S41467-023-43537-Z | 2023-12-06 | Yes | |
| OPRK | κ | Opioid | A | Human | Cryo-EM | 8FEG | - | 2.5 | B | Active | 100 | 73 | Gi/o | αi1 | - | 55 | - | scFv16 |
ACE-TYR-ALA-DTY-THR-THR-CYS-THR-DPN-XT9
|
peptide | Agonist | dynorphin B, dynorphin A-(1-13), dynorphin A-(1-8), β-endorphin, β-neoendorphin, α-neoendorphin, [Met]enkephalin, dynorphin A, [Leu]enkephalin, big dynorphin | peptide | No | No | Muratspahic E, Deibler K, Han J, Tomasevic N, Jadhav KB, Olive-Marti AL, Hochrainer N, Hellinger R, Koehbach J, Fay JF, Rahman MH, Hegazy L, Craven TW, Varga BR, Bhardwaj G, Appourchaux K, Majumdar S, Muttenthaler M, Hosseinzadeh P, Craik DJ, Spetea M, Che T, Baker D, Gruber CW | 10.1038/s41467-023-43718-w | 2023-12-06 | Yes | |
| CXCR3 | CXCR3 | Chemokine | A | Human | Cryo-EM | 8HNN | - | 3.6 | R | Inactive | 8 | 70 | - | - | - | - | - | Nanobody-6 |
CHEMBL1921858
|
small-molecule | Antagonist | CXCL11, CCL13, CCL11, CXCL10, CCL20, CXCL12α, CXCL9, CCL7, CCL19, CCL5 | peptide | No | No | Jiao H, Pang B, Liu A, Chen Q, Pan Q, Wang X, Xu Y, Chiang YC, Ren R, Hu H | 10.1038/S41594-023-01175-5 | 2023-11-29 | Yes | |
| CXCR3 | CXCR3 | Chemokine | A | Human | Cryo-EM | 8K2W | - | 3.0 | R | Inactive | 8 | 71 | - | - | - | - | BRIL | Nanobody-6 |
CHEMBL397983
|
small-molecule | Agonist | CXCL11, CCL13, CCL11, CXCL10, CCL20, CXCL12α, CXCL9, CCL7, CCL19, CCL5 | peptide | No | No | Jiao H, Pang B, Chiang YC, Chen Q, Pan Q, Ren R, Hu H | 10.1038/S41421-023-00617-0 | 2023-11-29 | Yes | |
| CXCR3 | CXCR3 | Chemokine | A | Human | Cryo-EM | 8HNM | - | 2.9 | R | Active | 100 | 75 | Gi/o | αi1 | - | 62 | - | scFv16 |
CHEMBL2220409
|
small-molecule | Agonist | CXCL11, CCL13, CCL11, CXCL10, CCL20, CXCL12α, CXCL9, CCL7, CCL19, CCL5 | peptide | No | No | Jiao H, Pang B, Liu A, Chen Q, Pan Q, Wang X, Xu Y, Chiang YC, Ren R, Hu H | 10.1038/S41594-023-01175-5 | 2023-11-29 | Yes | |
| CXCR3 | CXCR3 | Chemokine | A | Human | Cryo-EM | 8HNL | - | 3.0 | R | Active | 100 | 80 | - | - | - | - | - | - |
(3S)-N-[(2S)-5-carbamimidamido-1-(cyclohexylmethylamino)-1-oxidanylidene-pentan-2-yl]-2-(4-oxidanylidene-4-phenyl-butanoyl)-3,4-dihydro-1H-isoquinoline-3-carboxamide
|
small-molecule | Agonist | CXCL11, CCL13, CCL11, CXCL10, CCL20, CXCL12α, CXCL9, CCL7, CCL19, CCL5 | peptide | No | No | Jiao H, Pang B, Liu A, Chen Q, Pan Q, Wang X, Xu Y, Chiang YC, Ren R, Hu H | 10.1038/S41594-023-01175-5 | 2023-11-29 | Yes | |
| CXCR3 | CXCR3 | Chemokine | A | Human | Cryo-EM | 8K2X | 8K2X_refined | 3.2 | R | Active | 100 | 79 | Gi/o | αi1 | - | 62 | BRIL | scFv16 |
C-X-C motif chemokine 10
|
small-molecule | Agonist | CXCL11, CCL13, CCL11, CXCL10, CCL20, CXCL12α, CXCL9, CCL7, CCL19, CCL5 | peptide | No | No | Jiao H, Pang B, Chiang YC, Chen Q, Pan Q, Ren R, Hu H | 10.1038/S41421-023-00617-0 | 2023-11-29 | Yes | |
| CXCR3 | CXCR3 | Chemokine | A | Human | Cryo-EM | 8HNK | - | 3.0 | R | Active | 100 | 81 | Gi/o | αi1 | - | 62 | - | scFv16 |
CXCL11
|
peptide | Agonist | CXCL11, CCL13, CCL11, CXCL10, CCL20, CXCL12α, CXCL9, CCL7, CCL19, CCL5 | peptide | No | No | Jiao H, Pang B, Liu A, Chen Q, Pan Q, Wang X, Xu Y, Chiang YC, Ren R, Hu H | 10.1038/S41594-023-01175-5 | 2023-11-29 | Yes | |
| 5HT1A | 5-HT1A | 5-Hydroxytryptamine | A | Human | Cryo-EM | 8W8B | - | 3.0 | R | Active | 100 | 66 | Gi/o | αi1 | - | 61 | BRIL | scFv16 |
ulotaront
|
small-molecule | Agonist | 5-hydroxytryptamine | small-molecule | No | No | Liu H, Zheng Y, Wang Y, Wang Y, He X, Xu P, Huang S, Yuan Q, Zhang X, Wang L, Jiang K, Chen H, Li Z, Liu W, Wang S, Xu HE, Xu F | 10.1038/S41586-023-06775-1 | 2023-11-22 | Yes | |
| CASR | CaS | Calcium-sensing | C | Human | Cryo-EM | 8WPG | - | 2.7 | A | Inactive | - | 74 | - | - | - | - | - | - |
cinacalcet
Calcium |
small-molecule small-molecule |
Agonist | Mg2+, L-tryptophan, spermine, Ca2+ | small-molecule | No | No | Ling S, Meng X, Zhang Y, Xia Z, Zhou Y, Yang F, Shi P, Shi C, Tian C | 10.1038/S41422-023-00892-2 | 2023-11-22 | Yes | |
| CASR | CaS | Calcium-sensing | C | Human | Cryo-EM | 8WPU | - | 3.1 | A | Active | - | 74 | Gq/11 | αq | Gi2-mini-Gq chimera | 58 | - | scFv16 |
cinacalcet
Calcium |
small-molecule small-molecule |
Agonist | Mg2+, L-tryptophan, spermine, Ca2+ | small-molecule | No | No | Ling S, Meng X, Zhang Y, Xia Z, Zhou Y, Yang F, Shi P, Shi C, Tian C | 10.1038/S41422-023-00892-2 | 2023-11-22 | Yes | |
| HCAR2 | HCA2 | Hydroxycarboxylic acid | A | Human | Cryo-EM | 8K5C | - | 3.1 | A | Active | 99 | 80 | - | - | - | - | - | - |
5-Methyl-4-oxidanyl-pyrazin-4-ium-2-carboxylic acid
|
small-molecule | Agonist | butyric acid, β-D-hydroxybutyric acid | small-molecule | No | No | Park JH, Kawakami K, Ishimoto N, Ikuta T, Ohki M, Ekimoto T, Ikeguchi M, Lee DS, Lee YH, Tame JRH, Inoue A, Park SY | 10.1038/S41467-023-42764-8 | 2023-11-22 | Yes | |
| HCAR2 | HCA2 | Hydroxycarboxylic acid | A | Human | Cryo-EM | 8K5B | - | 3.4 | A | Active | 99 | 80 | - | - | - | - | - | - |
nicotinic acid
|
small-molecule | Agonist | butyric acid, β-D-hydroxybutyric acid | small-molecule | No | No | Park JH, Kawakami K, Ishimoto N, Ikuta T, Ohki M, Ekimoto T, Ikeguchi M, Lee DS, Lee YH, Tame JRH, Inoue A, Park SY | 10.1038/S41467-023-42764-8 | 2023-11-22 | Yes | |
| HCAR2 | HCA2 | Hydroxycarboxylic acid | A | Human | Cryo-EM | 8K5D | - | 3.7 | A | Active | 99 | 80 | - | - | - | - | - | - |
GSK256073
|
small-molecule | Agonist | butyric acid, β-D-hydroxybutyric acid | small-molecule | No | No | Park JH, Kawakami K, Ishimoto N, Ikuta T, Ohki M, Ekimoto T, Ikeguchi M, Lee DS, Lee YH, Tame JRH, Inoue A, Park SY | 10.1038/S41467-023-42764-8 | 2023-11-22 | Yes | |
| TAAR1 | TA1 | Trace amine | A | Human | Cryo-EM | 8W87 | - | 2.8 | R | Active | 100 | 85 | Gs | αs | - | 59 | - | Nanobody-35 |
METHAMPHETAMINE
|
small-molecule | Agonist | tyramine, (+)-Octopamine, octopamine, β-phenylethylamine, CHEMBL1160703, 3-iodothyronamine, dopamine | small-molecule | No | No | Liu H, Zheng Y, Wang Y, Wang Y, He X, Xu P, Huang S, Yuan Q, Zhang X, Wang L, Jiang K, Chen H, Li Z, Liu W, Wang S, Xu HE, Xu F | 10.1038/S41586-023-06775-1 | 2023-11-22 | Yes | |
| TAAR1 | TA1 | Trace amine | A | Human | Cryo-EM | 8W8A | - | 2.8 | R | Active | 100 | 85 | Gs | αs | - | 60 | - | Nanobody-35 |
CHEMBL3684869
|
small-molecule | Agonist | tyramine, (+)-Octopamine, octopamine, β-phenylethylamine, CHEMBL1160703, 3-iodothyronamine, dopamine | small-molecule | No | No | Liu H, Zheng Y, Wang Y, Wang Y, He X, Xu P, Huang S, Yuan Q, Zhang X, Wang L, Jiang K, Chen H, Li Z, Liu W, Wang S, Xu HE, Xu F | 10.1038/S41586-023-06775-1 | 2023-11-22 | Yes | |
| TAAR1 | TA1 | Trace amine | A | Human | Cryo-EM | 8W89 | - | 3.0 | R | Active | 100 | 84 | Gs | αs | - | 60 | - | Nanobody-35 |
2-Phenylethanaminium
|
small-molecule | Agonist | tyramine, (+)-Octopamine, octopamine, β-phenylethylamine, CHEMBL1160703, 3-iodothyronamine, dopamine | small-molecule | No | No | Liu H, Zheng Y, Wang Y, Wang Y, He X, Xu P, Huang S, Yuan Q, Zhang X, Wang L, Jiang K, Chen H, Li Z, Liu W, Wang S, Xu HE, Xu F | 10.1038/S41586-023-06775-1 | 2023-11-22 | Yes | |
| TAAR1 | TA1 | Trace amine | A | Human | Cryo-EM | 8W88 | - | 2.6 | R | Active | 100 | 83 | Gs | αs | - | 60 | - | Nanobody-35 |
ulotaront
|
small-molecule | Agonist | tyramine, (+)-Octopamine, octopamine, β-phenylethylamine, CHEMBL1160703, 3-iodothyronamine, dopamine | small-molecule | No | No | Liu H, Zheng Y, Wang Y, Wang Y, He X, Xu P, Huang S, Yuan Q, Zhang X, Wang L, Jiang K, Chen H, Li Z, Liu W, Wang S, Xu HE, Xu F | 10.1038/S41586-023-06775-1 | 2023-11-22 | Yes | |
| 5HT1A | 5-HT1A | 5-Hydroxytryptamine | A | Human | Cryo-EM | 8JSP | - | 3.7 | R | Active | 100 | 68 | Gi/o | αi1 | - | 61 | - | scFv16 |
ulotaront
|
small-molecule | Agonist | 5-hydroxytryptamine | small-molecule | No | No | Xu Z, Guo L, Yu J, Shen S, Wu C, Zhang W, Zhao C, Deng Y, Tian X, Feng Y, Hou H, Su L, Wang H, Guo S, Wang H, Wang K, Chen P, Zhao J, Zhang X, Yong X, Cheng L, Liu L, Yang S, Yang F, Wang X, Yu X, Xu Y, Sun JP, Yan W, Shao Z | 10.1038/S41586-023-06804-Z | 2023-11-15 | Yes | |
| NK1R | NK1 | Tachykinin | A | Human | Cryo-EM | 8U26 | 8U26_refined | 2.5 | R | Active | 100 | 70 | Gs | αs | - | 55 | - | Nanobody-35 |
substance P
|
peptide | Agonist | neurokinin A, neuropeptide K, hemokinin 1, neurokinin B, neuropeptide-γ, substance P | peptide | No | No | Chen M, Schmid MF, Chiu W | 10.1038/S41592-023-02082-9 | 2023-11-15 | Yes | |
| TAAR1 | TA1 | Trace amine | A | Human | Cryo-EM | 8JLQ | - | 2.8 | R | Active | 100 | 83 | Gs | αs | - | 58 | BRIL | scFv16 |
fenoldopam
|
small-molecule | Agonist | tyramine, (+)-Octopamine, octopamine, β-phenylethylamine, CHEMBL1160703, 3-iodothyronamine, dopamine | small-molecule | No | No | Xu Z, Guo L, Yu J, Shen S, Wu C, Zhang W, Zhao C, Deng Y, Tian X, Feng Y, Hou H, Su L, Wang H, Guo S, Wang H, Wang K, Chen P, Zhao J, Zhang X, Yong X, Cheng L, Liu L, Yang S, Yang F, Wang X, Yu X, Xu Y, Sun JP, Yan W, Shao Z | 10.1038/S41586-023-06804-Z | 2023-11-15 | Yes | |
| TAAR1 | TA1 | Trace amine | A | Mouse | Cryo-EM | 8JLJ | - | 3.1 | R | Active | 100 | 81 | Gs | αs | - | 59 | BRIL | scFv16 |
CHEMBL1182312
|
small-molecule | Agonist | tyramine, β-phenylethylamine, 3-iodothyronamine | small-molecule | No | No | Xu Z, Guo L, Yu J, Shen S, Wu C, Zhang W, Zhao C, Deng Y, Tian X, Feng Y, Hou H, Su L, Wang H, Guo S, Wang H, Wang K, Chen P, Zhao J, Zhang X, Yong X, Cheng L, Liu L, Yang S, Yang F, Wang X, Yu X, Xu Y, Sun JP, Yan W, Shao Z | 10.1038/S41586-023-06804-Z | 2023-11-15 | Yes | |
| TAAR1 | TA1 | Trace amine | A | Human | Cryo-EM | 8JSO | 8JSO_refined | 3.4 | R | Active | 100 | 83 | Gs | αs | - | 59 | BRIL | scFv16 |
dexamfetamine
|
small-molecule | Agonist | tyramine, (+)-Octopamine, octopamine, β-phenylethylamine, CHEMBL1160703, 3-iodothyronamine, dopamine | small-molecule | No | No | Xu Z, Guo L, Yu J, Shen S, Wu C, Zhang W, Zhao C, Deng Y, Tian X, Feng Y, Hou H, Su L, Wang H, Guo S, Wang H, Wang K, Chen P, Zhao J, Zhang X, Yong X, Cheng L, Liu L, Yang S, Yang F, Wang X, Yu X, Xu Y, Sun JP, Yan W, Shao Z | 10.1038/S41586-023-06804-Z | 2023-11-15 | Yes | |
| TAAR1 | TA1 | Trace amine | A | Mouse | Cryo-EM | 8JLK | - | 3.2 | R | Active | 100 | 81 | Gs | αs | - | 59 | - | scFv16 |
ulotaront
|
small-molecule | Agonist | tyramine, β-phenylethylamine, 3-iodothyronamine | small-molecule | No | No | Xu Z, Guo L, Yu J, Shen S, Wu C, Zhang W, Zhao C, Deng Y, Tian X, Feng Y, Hou H, Su L, Wang H, Guo S, Wang H, Wang K, Chen P, Zhao J, Zhang X, Yong X, Cheng L, Liu L, Yang S, Yang F, Wang X, Yu X, Xu Y, Sun JP, Yan W, Shao Z | 10.1038/S41586-023-06804-Z | 2023-11-15 | Yes | |
| TAAR1 | TA1 | Trace amine | A | Human | Cryo-EM | 8JLP | - | 3.2 | R | Active | 100 | 84 | Gs | αs | - | 61 | - | - |
ralmitaront
|
small-molecule | Agonist | tyramine, (+)-Octopamine, octopamine, β-phenylethylamine, CHEMBL1160703, 3-iodothyronamine, dopamine | small-molecule | No | No | Xu Z, Guo L, Yu J, Shen S, Wu C, Zhang W, Zhao C, Deng Y, Tian X, Feng Y, Hou H, Su L, Wang H, Guo S, Wang H, Wang K, Chen P, Zhao J, Zhang X, Yong X, Cheng L, Liu L, Yang S, Yang F, Wang X, Yu X, Xu Y, Sun JP, Yan W, Shao Z | 10.1038/S41586-023-06804-Z | 2023-11-15 | Yes | |
| TAAR1 | TA1 | Trace amine | A | Human | Cryo-EM | 8JLN | - | 3.2 | R | Active | 100 | 84 | Gs | αs | - | 61 | BRIL | scFv16 |
CHEMBL1182312
|
small-molecule | Agonist | tyramine, (+)-Octopamine, octopamine, β-phenylethylamine, CHEMBL1160703, 3-iodothyronamine, dopamine | small-molecule | No | No | Xu Z, Guo L, Yu J, Shen S, Wu C, Zhang W, Zhao C, Deng Y, Tian X, Feng Y, Hou H, Su L, Wang H, Guo S, Wang H, Wang K, Chen P, Zhao J, Zhang X, Yong X, Cheng L, Liu L, Yang S, Yang F, Wang X, Yu X, Xu Y, Sun JP, Yan W, Shao Z | 10.1038/S41586-023-06804-Z | 2023-11-15 | Yes | |
| TAAR1 | TA1 | Trace amine | A | Human | Cryo-EM | 8JLO | - | 3.5 | R | Active | 100 | 84 | Gs | αs | - | 61 | - | - |
ulotaront
|
small-molecule | Agonist | tyramine, (+)-Octopamine, octopamine, β-phenylethylamine, CHEMBL1160703, 3-iodothyronamine, dopamine | small-molecule | No | No | Xu Z, Guo L, Yu J, Shen S, Wu C, Zhang W, Zhao C, Deng Y, Tian X, Feng Y, Hou H, Su L, Wang H, Guo S, Wang H, Wang K, Chen P, Zhao J, Zhang X, Yong X, Cheng L, Liu L, Yang S, Yang F, Wang X, Yu X, Xu Y, Sun JP, Yan W, Shao Z | 10.1038/S41586-023-06804-Z | 2023-11-15 | Yes | |
| TAAR1 | TA1 | Trace amine | A | Human | Cryo-EM | 8JLR | - | 3.0 | R | Active | 100 | 79 | Gs | αs | - | 59 | BRIL | scFv16 |
(1~{S},3~{R})-3-(1-adamantyl)-1-(aminomethyl)-3,4-dihydro-1~{H}-isochromene-5,6-diol
|
small-molecule | Agonist | tyramine, (+)-Octopamine, octopamine, β-phenylethylamine, CHEMBL1160703, 3-iodothyronamine, dopamine | small-molecule | No | No | Xu Z, Guo L, Yu J, Shen S, Wu C, Zhang W, Zhao C, Deng Y, Tian X, Feng Y, Hou H, Su L, Wang H, Guo S, Wang H, Wang K, Chen P, Zhao J, Zhang X, Yong X, Cheng L, Liu L, Yang S, Yang F, Wang X, Yu X, Xu Y, Sun JP, Yan W, Shao Z | 10.1038/S41586-023-06804-Z | 2023-11-15 | Yes | |
| GLP1R | GLP-1 | Glucagon | B1 | Human | Cryo-EM | 8JIS | 8JIS_refined | 2.5 | R | Active | 100 | 83 | Gs | αs | - | 60 | - | Nanobody-35 |
Dual-agonist peptide P15
|
peptide | Agonist | glucagon-like peptide 1-(7-36) amide, glucagon, glucagon-like peptide 1-(7-37) | peptide | No | No | Li Y, Zhou Q, Dai A, Zhao F, Chang R, Ying T, Wu B, Yang D, Wang MW, Cong Z | 10.1073/PNAS.2303696120 | 2023-11-08 | Yes | |
| GPR34 | GPR34 | A orphans | A | Human | Cryo-EM | 8WRB | - | 2.9 | R | Active | 100 | 74 | Gi/o | αi1 | - | 63 | - | scFv16 |
LYSOPHOSPHATIDIC ACID
|
small-molecule | Agonist | lysophosphatidylserine | small-molecule | No | No | Liu G, Li X, Wang Y, Zhang X, Gong W | 10.1371/JOURNAL.PBIO.3002387 | 2023-11-08 | Yes | |
| CML1 | chemerin | Chemerin receptor | A | Human | Cryo-EM | 8SG1 | - | 2.9 | R | Active | 100 | 75 | Gi/o | αi1 | - | 61 | - | scFv16 |
chemerin C-terminal peptide
|
peptide | Agonist | 18R-HEPE, resolvin E1, chemerin C-terminal peptide, chemerin, EPA | peptide | No | No | Zhang X, Weiss T, Cheng MH, Chen S, Ambrosius CK, Czerniak AS, Li K, Feng M, Bahar I, Beck-Sickinger AG, Zhang C | 10.1371/JOURNAL.PBIO.3002188 | 2023-11-01 | Yes | |
| GP174 | GPR174 | A orphans | A | Human | Cryo-EM | 8IZB | - | 3.1 | R | Active | 100 | 85 | Gs | αs | - | 60 | - | Nanobody-35 |
LYSOPHOSPHATIDIC ACID
L-serine |
small-molecule small-molecule |
Agonist | lysophosphatidylserine | small-molecule | No | No | Liu G, Li X, Wang Y, Zhang X, Gong W | 10.1371/JOURNAL.PBIO.3002387 | 2023-11-01 | Yes | |
| GPR84 | GPR84 | A orphans | A | Human | Cryo-EM | 8G05 | - | 3.0 | R | Active | 100 | 72 | Gi/o | αi1 | - | 63 | - | scFv16 |
6-Octylimino-1,3-diazinane-2,4-dione
|
lipid | Agonist | - | - | No | No | Zhang X, Wang Y, Supekar S, Cao X, Zhou J, Dang J, Chen S, Jenkins L, Marsango S, Li X, Liu G, Milligan G, Feng M, Fan H, Gong W, Zhang C | 10.1038/S41467-023-41201-0 | 2023-11-01 | Yes | |
| AA2AR | A2A | Adenosine | A | Human | X-ray | 8PWN | - | 2.4 | A | Inactive | 1 | 72 | - | - | - | - | BRIL | - |
theophylline
|
small-molecule | Antagonist | adenosine | small-molecule | No | No | El Omari K, Duman R, Mykhaylyk V, Orr CM, Latimer-Smith M, Winter G, Grama V, Qu F, Bountra K, Kwong HS, Romano M, Reis RI, Vogeley L, Vecchia L, Owen CD, Wittmann S, Renner M, Senda M, Matsugaki N, Kawano Y, Bowden TA, Moraes I, Grimes JM, Mancini EJ, Walsh MA, Guzzo CR, Owens RJ, Jones EY, Brown DG, Stuart DI, Beis K, Wagner A | 10.1038/S42004-023-01014-0 | 2023-10-25 | Yes | |
| GPR34 | GPR34 | A orphans | A | Human | Cryo-EM | 8K4N | 8K4N_refined | 2.8 | D | Active | 100 | 73 | Gi/o | αi1 | - | 61 | - | scFv16 |
(2R)-2-azanyl-3-[oxidanyl-[(2R)-2-oxidanyl-3-tetradec-9-enoyloxy-propoxy]phosphoryl]oxy-propanoic acid
|
small-molecule | Agonist | lysophosphatidylserine | small-molecule | No | No | - | - | 2023-10-25 | Yes | |
| HRH4 | H4 | Histamine | A | Human | Cryo-EM | 7YFC | - | 3.0 | R | Active | 100 | 67 | Gq/11 | αq | - | 62 | - | scFv16 Nanobody-35 |
histamine
|
small-molecule | Agonist | histamine, CCL16 | small-molecule | No | No | Im D, Kishikawa JI, Shiimura Y, Hisano H, Ito A, Fujita-Fujiharu Y, Sugita Y, Noda T, Kato T, Asada H, Iwata S | 10.1038/S41467-023-42260-Z | 2023-10-25 | Yes | |
| HRH4 | H4 | Histamine | A | Human | Cryo-EM | 7YFD | - | 3.1 | R | Active | 100 | 67 | Gq/11 | αq | - | 62 | - | scFv16 Nanobody-35 |
imetit
|
small-molecule | Agonist | histamine, CCL16 | small-molecule | No | No | Im D, Kishikawa JI, Shiimura Y, Hisano H, Ito A, Fujita-Fujiharu Y, Sugita Y, Noda T, Kato T, Asada H, Iwata S | 10.1038/S41467-023-42260-Z | 2023-10-25 | Yes | |
| C3AR | C3a | Complement peptide | A | Human | Cryo-EM | 8J6D | 8J6D_refined | 3.1 | C | Active | 100 | 58 | Gi/o | αo | - | 59 | - | scFv16 |
EP141 peptide agonist
|
peptide | Agonist | C5a, C3a | peptide | No | No | Yadav MK, Maharana J, Yadav R, Saha S, Sarma P, Soni C, Singh V, Saha S, Ganguly M, Li XX, Mohapatra S, Mishra S, Khant HA, Chami M, Woodruff TM, Banerjee R, Shukla AK, Gati C | 10.1016/J.CELL.2023.09.020 | 2023-10-18 | Yes | |
| C3AR | C3a | Complement peptide | A | Human | Cryo-EM | 8I9S | 8I9S_refined | 3.3 | C | Active | 100 | 57 | Gi/o | αo | - | 59 | - | scFv16 |
Apo (no ligand)
|
none | Apo (no ligand) | C5a, C3a | peptide | No | No | Yadav MK, Maharana J, Yadav R, Saha S, Sarma P, Soni C, Singh V, Saha S, Ganguly M, Li XX, Mohapatra S, Mishra S, Khant HA, Chami M, Woodruff TM, Banerjee R, Shukla AK, Gati C | 10.1016/J.CELL.2023.09.020 | 2023-10-18 | Yes | |
| C3AR | C3a | Complement peptide | A | Human | Cryo-EM | 8I9A | - | 3.6 | C | Active | 100 | 56 | Gq/11 | αq | - | 58 | - | scFv16 |
EP54 ligand
|
peptide | Agonist | C5a, C3a | peptide | No | No | Yadav MK, Maharana J, Yadav R, Saha S, Sarma P, Soni C, Singh V, Saha S, Ganguly M, Li XX, Mohapatra S, Mishra S, Khant HA, Chami M, Woodruff TM, Banerjee R, Shukla AK, Gati C | 10.1016/J.CELL.2023.09.020 | 2023-10-18 | Yes | |
| C3AR | C3a | Complement peptide | A | Human | Cryo-EM | 8I97 | 8I97_refined | 3.2 | C | Active | 100 | 57 | Gi/o | αo | - | 59 | - | scFv16 |
Apo (no ligand)
|
none | Apo (no ligand) | C5a, C3a | peptide | No | No | Yadav MK, Maharana J, Yadav R, Saha S, Sarma P, Soni C, Singh V, Saha S, Ganguly M, Li XX, Mohapatra S, Mishra S, Khant HA, Chami M, Woodruff TM, Banerjee R, Shukla AK, Gati C | 10.1016/J.CELL.2023.09.020 | 2023-10-18 | Yes | |
| C3AR | C3a | Complement peptide | A | Human | Cryo-EM | 8I9L | - | 3.2 | C | Active | 100 | 57 | Gi/o | αo | - | 59 | - | scFv16 |
C3a anaphylatoxin
|
peptide | Agonist | C5a, C3a | peptide | No | No | Yadav MK, Maharana J, Yadav R, Saha S, Sarma P, Soni C, Singh V, Saha S, Ganguly M, Li XX, Mohapatra S, Mishra S, Khant HA, Chami M, Woodruff TM, Banerjee R, Shukla AK, Gati C | 10.1016/J.CELL.2023.09.020 | 2023-10-18 | Yes | |
| C3AR | C3a | Complement peptide | A | Human | Cryo-EM | 8I95 | - | 2.9 | C | Active | 100 | 58 | Gi/o | αo | - | 59 | - | scFv16 |
EP54 ligand
|
peptide | Agonist | C5a, C3a | peptide | No | No | Yadav MK, Maharana J, Yadav R, Saha S, Sarma P, Soni C, Singh V, Saha S, Ganguly M, Li XX, Mohapatra S, Mishra S, Khant HA, Chami M, Woodruff TM, Banerjee R, Shukla AK, Gati C | 10.1016/J.CELL.2023.09.020 | 2023-10-18 | Yes | |
| C5AR1 | C5a1 | Complement peptide | A | Mouse | Cryo-EM | 8HPT | - | 3.4 | A | Active | 100 | 73 | Gi/o | αo | - | 58 | - | scFv16 |
C5a
|
peptide | Agonist | - | - | No | No | - | HTTPS://DOI.ORG/10.1016/J.CELL.2023.09.020 | 2023-10-18 | Yes | |
| C5AR1 | C5a1 | Complement peptide | A | Mouse | Cryo-EM | 8HQC | - | 3.9 | A | Active | 100 | 78 | Gi/o | αo | - | 60 | - | - |
C5a
|
peptide | Agonist | - | - | No | No | - | HTTPS://DOI.ORG/10.1016/J.CELL.2023.09.020 | 2023-10-18 | Yes | |
| C5AR1 | C5a1 | Complement peptide | A | Human | Cryo-EM | 8JZZ | 8JZZ_refined | 3.3 | A | Active | 100 | 84 | Gi/o | αo | - | 59 | - | scFv16 |
C5a des-Arg
|
peptide | Agonist | C5a, ribosomal protein S19, C5a des-Arg, C3a | peptide | No | No | Yadav MK, Maharana J, Yadav R, Saha S, Sarma P, Soni C, Singh V, Saha S, Ganguly M, Li XX, Mohapatra S, Mishra S, Khant HA, Chami M, Woodruff TM, Banerjee R, Shukla AK, Gati C | 10.1016/J.CELL.2023.09.020 | 2023-10-18 | Yes | |
| C5AR1 | C5a1 | Complement peptide | A | Human | Cryo-EM | 8IA2 | 8IA2_refined | 3.2 | A | Active | 100 | 84 | Gi/o | αo | - | 59 | - | scFv16 |
C5a
|
peptide | Agonist | C5a, ribosomal protein S19, C5a des-Arg, C3a | peptide | No | No | Yadav MK, Maharana J, Yadav R, Saha S, Sarma P, Soni C, Singh V, Saha S, Ganguly M, Li XX, Mohapatra S, Mishra S, Khant HA, Chami M, Woodruff TM, Banerjee R, Shukla AK, Gati C | 10.1016/J.CELL.2023.09.020 | 2023-10-18 | Yes | |
| GIPR | GIP | Glucagon | B1 | Human | Cryo-EM | 8ITL | - | 3.2 | R | Active | 100 | 60 | Gs | αs | - | 59 | - | Nanobody-35 |
Apo (no ligand)
|
none | Apo (no ligand) | gastric inhibitory polypeptide | peptide | No | No | Zhao F, Hang K, Zhou Q, Shao L, Li H, Li W, Lin S, Dai A, Cai X, Liu Y, Xu Y, Feng W, Yang D, Wang MW | 10.1073/PNAS.2306145120 | 2023-10-18 | Yes | |
| GIPR | GIP | Glucagon | B1 | Human | Cryo-EM | 8ITM | - | 3.1 | R | Active | 100 | 60 | Gs | αs | - | 59 | - | Nanobody-35 |
Apo (no ligand)
|
none | Apo (no ligand) | gastric inhibitory polypeptide | peptide | No | No | Zhao F, Hang K, Zhou Q, Shao L, Li H, Li W, Lin S, Dai A, Cai X, Liu Y, Xu Y, Feng W, Yang D, Wang MW | 10.1073/PNAS.2306145120 | 2023-10-18 | Yes | |
| GP174 | GPR174 | A orphans | A | Human | Cryo-EM | 8KH5 | - | 2.8 | A | Active | 100 | 84 | Gs | αs | - | 58 | - | Nanobody-35 |
Lysophosphotidylserine
|
small-molecule | Agonist | lysophosphatidylserine | small-molecule | No | No | Nie Y, Qiu Z, Chen S, Chen Z, Song X, Ma Y, Huang N, Cyster JG, Zheng S | 10.1038/S41467-023-41654-3 | 2023-10-18 | Yes | |
| OPRM | μ | Opioid | A | Mouse | X-ray | 8E0G | - | 2.1 | A | Active | 100 | 74 | - | - | - | - | - | Nanobody-39 |
BU72
|
small-molecule | Agonist | - | - | No | No | Munro TA | 10.1186/S12915-023-01689-W | 2023-10-18 | Yes | |
| GP132 | GPR132 | A orphans | A | Human | Cryo-EM | 8HQN | 8HQN_refined | 3.0 | R | Active | 100 | 82 | Gi/o | αi1 | - | 60 | BRIL | scFv16 |
9-hydroxyoctadecadienoic acid
|
small-molecule | Agonist | 9-hydroxyoctadecadienoic acid | small-molecule | No | No | Wang JL, Dou XD, Cheng J, Gao MX, Xu GF, Ding W, Ding JH, Li Y, Wang SH, Ji ZW, Zhao XY, Huo TY, Zhang CF, Liu YM, Sha XY, Gao JR, Zhang WH, Hao Y, Zhang C, Sun JP, Jiao N, Yu X | 10.1038/S42255-023-00899-4 | 2023-10-11 | Yes | |
| GP132 | GPR132 | A orphans | A | Human | Cryo-EM | 8HQE | 8HQE_refined | 3.0 | R | Active | 100 | 81 | Gi/o | αi1 | - | 60 | BRIL | scFv16 |
Apo (no ligand)
|
none | Apo (no ligand) | 9-hydroxyoctadecadienoic acid | small-molecule | No | No | Wang JL, Dou XD, Cheng J, Gao MX, Xu GF, Ding W, Ding JH, Li Y, Wang SH, Ji ZW, Zhao XY, Huo TY, Zhang CF, Liu YM, Sha XY, Gao JR, Zhang WH, Hao Y, Zhang C, Sun JP, Jiao N, Yu X | 10.1038/S42255-023-00899-4 | 2023-10-11 | Yes | |
| GP132 | GPR132 | A orphans | A | Human | Cryo-EM | 8HQM | 8HQM_refined | 3.0 | R | Active | 100 | 81 | Gi/o | αi1 | - | 60 | BRIL | scFv16 |
CHEMBL3354065
|
small-molecule | Agonist | 9-hydroxyoctadecadienoic acid | small-molecule | No | No | Wang JL, Dou XD, Cheng J, Gao MX, Xu GF, Ding W, Ding JH, Li Y, Wang SH, Ji ZW, Zhao XY, Huo TY, Zhang CF, Liu YM, Sha XY, Gao JR, Zhang WH, Hao Y, Zhang C, Sun JP, Jiao N, Yu X | 10.1038/S42255-023-00899-4 | 2023-10-11 | Yes | |
| GP132 | GPR132 | A orphans | A | Human | Cryo-EM | 8HVI | 8HVI_refined | 3.0 | R | Active | 100 | 81 | Gi/o | αi1 | - | 60 | BRIL | scFv16 |
NOX-6-7
|
small-molecule | Agonist | 9-hydroxyoctadecadienoic acid | small-molecule | No | No | Wang JL, Dou XD, Cheng J, Gao MX, Xu GF, Ding W, Ding JH, Li Y, Wang SH, Ji ZW, Zhao XY, Huo TY, Zhang CF, Liu YM, Sha XY, Gao JR, Zhang WH, Hao Y, Zhang C, Sun JP, Jiao N, Yu X | 10.1038/S42255-023-00899-4 | 2023-10-11 | Yes | |
| GP161 | GPR161 | A orphans | A | Human | Cryo-EM | 8KH4 | 8KH4_refined | 3.1 | A | Active | 100 | 50 | Gs | αs | - | 58 | - | Nanobody-35 |
Apo (no ligand)
|
none | Apo (no ligand) | - | - | No | No | Nie Y, Qiu Z, Chen S, Chen Z, Song X, Ma Y, Huang N, Cyster JG, Zheng S | 10.1038/S41467-023-41654-3 | 2023-10-11 | Yes | |
| GPR61 | GPR61 | A orphans | A | Human | Cryo-EM | 8KGK | 8KGK_refined | 3.2 | A | Active | 100 | 57 | Gs | αs | - | 58 | - | Nanobody-35 |
Apo (no ligand)
|
none | Apo (no ligand) | - | - | No | No | Nie Y, Qiu Z, Chen S, Chen Z, Song X, Ma Y, Huang N, Cyster JG, Zheng S | 10.1038/S41467-023-41654-3 | 2023-10-11 | Yes | |
| GRM5 | mGlu5 | Metabotropic glutamate | C | Human | Cryo-EM | 8T8M | - | 3.0 | A | Intermediate | - | 62 | - | - | - | - | - | Nanobody-43 |
quisqualate
|
small-molecule | Agonist | L-glutamic acid | small-molecule | No | No | Kumar KK, Wang H, Habrian C, Latorraca NR, Xu J, O'Brien ES, Zhang C, Montabana E, Koehl A, Marqusee S, Isacoff EY, Kobilka BK | 10.1101/2023.08.29.555158 | 2023-10-11 | Yes | |
| GRM5 | mGlu5 | Metabotropic glutamate | C | Human | Cryo-EM | 8T6J | - | 3.5 | A | Inactive | - | 63 | - | - | - | - | - | - |
CDPPB
|
small-molecule | Agonist | L-glutamic acid | small-molecule | No | No | Kumar KK, Wang H, Habrian C, Latorraca NR, Xu J, O'Brien ES, Zhang C, Montabana E, Koehl A, Marqusee S, Isacoff EY, Kobilka BK | 10.1101/2023.08.29.555158 | 2023-10-11 | Yes | |
| GRM5 | mGlu5 | Metabotropic glutamate | C | Human | Cryo-EM | 8TAO | - | 2.9 | A | Active | - | 64 | - | - | - | - | - | Nanobody-43 |
quisqualate
CDPPB |
small-molecule small-molecule |
Agonist | L-glutamic acid | small-molecule | No | No | Kumar KK, Wang H, Habrian C, Latorraca NR, Xu J, O'Brien ES, Zhang C, Montabana E, Koehl A, Marqusee S, Isacoff EY, Kobilka BK | 10.1101/2023.08.29.555158 | 2023-10-11 | Yes | |
| GRM5 | mGlu5 | Metabotropic glutamate | C | Human | Cryo-EM | 8T7H | - | 3.3 | A | Intermediate | - | 64 | - | - | - | - | - | Nanobody-43 |
quisqualate
|
small-molecule | Agonist | L-glutamic acid | small-molecule | No | No | Kumar KK, Wang H, Habrian C, Latorraca NR, Xu J, O'Brien ES, Zhang C, Montabana E, Koehl A, Marqusee S, Isacoff EY, Kobilka BK | 10.1101/2023.08.29.555158 | 2023-10-11 | Yes | |
| HCAR2 | HCA2 | Hydroxycarboxylic acid | A | Human | Cryo-EM | 8H2G | 8H2G_refined | 3.0 | A | Active | 100 | 80 | Gi/o | αi1 | - | 63 | - | scFv16 |
nicotinic acid
|
small-molecule | Agonist | butyric acid, β-D-hydroxybutyric acid | small-molecule | No | No | - | - | 2023-10-11 | Yes | |
| GPR34 | GPR34 | A orphans | A | Human | Cryo-EM | 8SAI | 8SAI_refined | 3.3 | A | Active | 100 | 76 | Gi/o | αi1 | - | 64 | - | scFv16 |
O-[(S)-Hydroxy{[(2s)-2-Hydroxy-3-(Octadec-9-Enoyloxy)propyl]oxy}phosphoryl]-L-Serine
|
small-molecule | Agonist | lysophosphatidylserine | small-molecule | No | No | Xia A, Yong X, Zhang C, Lin G, Jia G, Zhao C, Wang X, Hao Y, Wang Y, Zhou P, Yang X, Deng Y, Wu C, Chen Y, Zhu J, Tang X, Liu J, Zhang S, Zhang J, Xu Z, Hu Q, Zhao J, Yue Y, Yan W, Su Z, Wei Y, Zhou R, Dong H, Shao Z, Yang S | 10.1073/PNAS.2308435120 | 2023-10-04 | Yes | |
| GPR61 | GPR61 | A orphans | A | Human | Cryo-EM | 8TB7 | - | 2.9 | R | Active | 94 | 47 | - | - | - | - | BRIL | Fab24 BAK5 heavy chain Fab hinge-binding nanobody Fab24 BAK5 light chain |
compound 1 [PMID: 37741852]
|
small-molecule | Inverse agonist | - | - | No | No | Lees JA, Dias JM, Rajamohan F, Fortin JP, O'Connor R, Kong JX, Hughes EAG, Fisher EL, Tuttle JB, Lovett G, Kormos BL, Unwalla RJ, Zhang L, Dechert Schmitt AM, Zhou D, Moran M, Stevens KA, Fennell KF, Varghese AE, Maxwell A, Cote EE, Zhang Y, Han S | 10.1038/S41467-023-41646-3 | 2023-10-04 | Yes | |
| GPR61 | GPR61 | A orphans | A | Human | Cryo-EM | 8TB0 | 8TB0_refined | 3.5 | R | Active | 100 | 56 | Gs | αs | - | 56 | - | scFv16 |
Apo (no ligand)
|
none | Apo (no ligand) | - | - | No | No | - | - | 2023-10-04 | Yes | |
| HCAR2 | HCA2 | Hydroxycarboxylic acid | A | Human | Cryo-EM | 8JZ7 | 8JZ7_refined | 2.6 | A | Active | 100 | 80 | Gi/o | αi1 | - | 64 | - | scFv16 |
MK 6892
|
small-molecule | Agonist | butyric acid, β-D-hydroxybutyric acid | small-molecule | No | No | Cheng L, Sun S, Wang H, Zhao C, Tian X, Liu Y, Fu P, Shao Z, Chai R, Yan W | 10.1038/S41392-023-01625-Y | 2023-10-04 | Yes | |
| MC3R | MC3 | Melanocortin | A | Human | Cryo-EM | 8IOC | - | 2.9 | R | Active | 100 | 84 | Gs | αs | Gi1-Gs chimera | 60 | - | Nanobody-35 |
γ-MSH
|
peptide | Agonist | γ-MSH, α-MSH, β-MSH, ACTH, agouti-related protein | peptide | No | No | Chen VB, Arendall WB 3rd, Headd JJ, Keedy DA, Immormino RM, Kapral GJ, Murray LW, Richardson JS, Richardson DC | 10.1107/S0907444909042073 | 2023-09-20 | Yes | |
| MC5R | MC5 | Melanocortin | A | Human | Cryo-EM | 8IOD | - | 2.6 | R | Active | 100 | 83 | Gs | αs | Gi1-Gs chimera | 59 | - | Nanobody-35 |
PG-901
|
peptide | Agonist | γ-MSH, α-MSH, β-MSH, ACTH, agouti-related protein | peptide | No | No | Chen VB, Arendall WB 3rd, Headd JJ, Keedy DA, Immormino RM, Kapral GJ, Murray LW, Richardson JS, Richardson DC | 10.1107/S0907444909042073 | 2023-09-20 | Yes | |
| MC5R | MC5 | Melanocortin | A | Human | Cryo-EM | 8INR | - | 2.7 | R | Active | 100 | 83 | Gs | αs | Gi1-Gs chimera | 60 | - | - |
INTERMEDINE
|
protein | Agonist | γ-MSH, α-MSH, β-MSH, ACTH, agouti-related protein | peptide | No | No | Chen VB, Arendall WB 3rd, Headd JJ, Keedy DA, Immormino RM, Kapral GJ, Murray LW, Richardson JS, Richardson DC | 10.1107/S0907444909042073 | 2023-09-20 | Yes | |
| ACM4 | M4 | Acetylcholine (muscarinic) | A | Human | Cryo-EM | 8FX5 | - | 2.5 | R | Active | 100 | 57 | Gi/o | αi1 | - | 64 | - | scFv16 |
xanomeline
|
small-molecule | Agonist | acetylcholine | small-molecule | No | No | Burger WAC, Pham V, Vuckovic Z, Powers AS, Mobbs JI, Laloudakis Y, Glukhova A, Wootten D, Tobin AB, Sexton PM, Paul SM, Felder CC, Danev R, Dror RO, Christopoulos A, Valant C, Thal DM | 10.1038/S41467-023-41199-5 | 2023-09-13 | Yes | |
| CRFR1 | CRF1 | Corticotropin-releasing factor | B1 | Human | X-ray | 8GTI | - | 2.2 | A | Inactive | 16 | 63 | - | - | - | - | Endolysin | - |
8-(4-bromo-2,6-dimethoxyphenyl)-N-butyl-N-(cyclopropylmethyl)-2,7-dimethylpyrazolo[1,5-a][1,3,5]triazin-4-amine
|
small-molecule | Antagonist | urocortin 1, urocortin 2, corticotrophin-releasing hormone | peptide | No | No | Kim H, Lim T, Ha GE, Lee JY, Kim JW, Chang N, Kim SH, Kim KH, Lee J, Cho Y, Kim BW, Abrahamsson A, Kim SH, Kim HJ, Park S, Lee SJ, Park J, Cheong E, Kim BM, Cho HS | 10.1038/S12276-023-01082-1 | 2023-09-13 | Yes | |
| CRFR1 | CRF1 | Corticotropin-releasing factor | B1 | Human | X-ray | 8GTG | - | 2.8 | A | Inactive | 16 | 63 | - | - | - | - | Endolysin | - |
8-(4-bromo-2,6-dimethoxyphenyl)-N,N-bis(2-methoxyethyl)-2,7-dimethylpyrazolo[1,5-a][1,3,5]triazin-4-amine
|
small-molecule | Antagonist | urocortin 1, urocortin 2, corticotrophin-releasing hormone | peptide | No | No | Kim H, Lim T, Ha GE, Lee JY, Kim JW, Chang N, Kim SH, Kim KH, Lee J, Cho Y, Kim BW, Abrahamsson A, Kim SH, Kim HJ, Park S, Lee SJ, Park J, Cheong E, Kim BM, Cho HS | 10.1038/S12276-023-01082-1 | 2023-09-13 | Yes | |
| CRFR1 | CRF1 | Corticotropin-releasing factor | B1 | Human | X-ray | 8GTM | - | 2.6 | A | Inactive | 16 | 63 | - | - | - | - | Endolysin | - |
7-(4-bromanyl-2,6-dimethoxy-phenyl)-4,8-dimethyl-~{N},~{N}-bis[4,4,4-tris(fluoranyl)butyl]-1$l^{4},3,5,9-tetrazabicyclo[4.3.0]nona-1(6),2,4,8-tetraen-2-amine
|
small-molecule | Antagonist | urocortin 1, urocortin 2, corticotrophin-releasing hormone | peptide | No | No | Kim H, Lim T, Ha GE, Lee JY, Kim JW, Chang N, Kim SH, Kim KH, Lee J, Cho Y, Kim BW, Abrahamsson A, Kim SH, Kim HJ, Park S, Lee SJ, Park J, Cheong E, Kim BM, Cho HS | 10.1038/S12276-023-01082-1 | 2023-09-13 | Yes | |
| GLR | glucagon | Glucagon | B1 | Human | Cryo-EM | 8JIQ | 8JIQ_refined | 3.4 | R | Active | 100 | 79 | Gs | αs | - | 56 | - | Nanobody-35 |
Dual-agonist peptide P15
|
peptide | Agonist | glucagon | peptide | No | No | - | - | 2023-09-13 | Yes | |
| GLR | glucagon | Glucagon | B1 | Human | Cryo-EM | 8JIU | 8JIU_refined | 2.8 | R | Active | 100 | 83 | Gs | αs | - | 59 | - | Nanobody-35 |
SAR425899
|
peptide | Agonist | glucagon | peptide | No | No | Li Y, Zhou Q, Dai A, Zhao F, Chang R, Ying T, Wu B, Yang D, Wang MW, Cong Z | 10.1073/PNAS.2303696120 | 2023-09-13 | Yes | |
| HCAR2 | HCA2 | Hydroxycarboxylic acid | A | Human | Cryo-EM | 8IHB | - | 2.9 | R | Active | 100 | 80 | Gi/o | αi1 | - | 62 | BRIL | - |
GSK256073
|
small-molecule | Agonist | butyric acid, β-D-hydroxybutyric acid | small-molecule | No | No | Suzuki S, Tanaka K, Nishikawa K, Suzuki H, Oshima A, Fujiyoshi Y | 10.1038/S41467-023-41650-7 | 2023-09-13 | Yes | |
| ADRB2 | β2 | Adrenoceptors | A | Human | Cryo-EM | 8JJ8 | - | 3.2 | F | Active | 99 | 68 | - | - | - | - | BRIL | - |
ARFORMOTEROL
|
small-molecule | Agonist (partial) | Zn2+, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline | small-molecule | No | No | Guo Q, He B, Zhong Y, Jiao H, Ren Y, Wang Q, Ge Q, Gao Y, Liu X, Du Y, Hu H, Tao Y | 10.1038/S41589-023-01389-0 | 2023-09-06 | Yes | |
| ADRB2 | β2 | Adrenoceptors | A | Human | Cryo-EM | 8JJL | - | 3.2 | A | Inactive | 0 | 68 | - | - | - | - | BRIL | - |
olodaterol
|
small-molecule | Agonist | Zn2+, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline | small-molecule | No | No | Guo Q, He B, Zhong Y, Jiao H, Ren Y, Wang Q, Ge Q, Gao Y, Liu X, Du Y, Hu H, Tao Y | 10.1038/S41589-023-01389-0 | 2023-09-06 | Yes | |
| ADRB2 | β2 | Adrenoceptors | A | Human | Cryo-EM | 8JJO | - | 3.4 | F | Inactive | 0 | 65 | - | - | - | - | BRIL | - |
CHEMBL1160734
|
small-molecule | Antagonist | Zn2+, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline | small-molecule | No | No | Guo Q, He B, Zhong Y, Jiao H, Ren Y, Wang Q, Ge Q, Gao Y, Liu X, Du Y, Hu H, Tao Y | 10.1038/S41589-023-01389-0 | 2023-09-06 | Yes | |
| AGRL3 | ADGRL3 | ADGRL | B2 | Human | Cryo-EM | 8JMT | - | 3.3 | A | Inactive | 0 | 16 | - | - | - | - | BRIL | - |
Apo (no ligand)
|
none | Apo (no ligand) | - | - | No | No | Guo Q, He B, Zhong Y, Jiao H, Ren Y, Wang Q, Ge Q, Gao Y, Liu X, Du Y, Hu H, Tao Y | 10.1038/S41589-023-01389-0 | 2023-09-06 | Yes | |
| GLP1R | GLP-1 | Glucagon | B1 | Human | Cryo-EM | 8JIP | 8JIP_refined | 2.9 | R | Active | 100 | 83 | Gs | αs | - | 62 | - | Nanobody-35 |
MEDI0382
|
peptide | Agonist | glucagon-like peptide 1-(7-36) amide, glucagon, glucagon-like peptide 1-(7-37) | peptide | No | No | Li Y, Zhou Q, Dai A, Zhao F, Chang R, Ying T, Wu B, Yang D, Wang MW, Cong Z | 10.1073/PNAS.2303696120 | 2023-09-06 | Yes | |
| GLP1R | GLP-1 | Glucagon | B1 | Human | Cryo-EM | 8JIR | 8JIR_refined | 2.6 | R | Active | 100 | 83 | Gs | αs | - | 58 | - | Nanobody-35 |
SAR425899
|
peptide | Agonist | glucagon-like peptide 1-(7-36) amide, glucagon, glucagon-like peptide 1-(7-37) | peptide | No | No | Li Y, Zhou Q, Dai A, Zhao F, Chang R, Ying T, Wu B, Yang D, Wang MW, Cong Z | 10.1073/PNAS.2303696120 | 2023-09-06 | Yes | |
| GLR | glucagon | Glucagon | B1 | Human | Cryo-EM | 8JIT | - | 2.9 | R | Active | 100 | 83 | Gs | αs | - | 58 | - | Nanobody-35 |
MEDI0382
|
peptide | Agonist | glucagon | peptide | No | No | Li Y, Zhou Q, Dai A, Zhao F, Chang R, Ying T, Wu B, Yang D, Wang MW, Cong Z | 10.1073/PNAS.2303696120 | 2023-09-06 | Yes | |
| HCAR2 | HCA2 | Hydroxycarboxylic acid | A | Human | Cryo-EM | 8JIM | - | 3.0 | E | Active | 100 | 80 | Gi/o | αi1 | - | 64 | - | scFv16 |
CHEMBL3354065
|
small-molecule | Agonist | butyric acid, β-D-hydroxybutyric acid | small-molecule | No | No | Zhao C, Wang H, Liu Y, Cheng L, Wang B, Tian X, Fu H, Wu C, Li Z, Shen C, Yu J, Yang S, Hu H, Fu P, Ma L, Wang C, Yan W, Shao Z | 10.1016/J.MOLCEL.2023.07.030 | 2023-09-06 | Yes | |
| HCAR2 | HCA2 | Hydroxycarboxylic acid | A | Human | Cryo-EM | 8JII | - | 3.2 | A | Active | 100 | 80 | Gi/o | αi1 | - | 64 | - | scFv16 |
nicotinic acid
compound 9n [PMID: 18752940] |
small-molecule small-molecule |
Agonist PAM |
butyric acid, β-D-hydroxybutyric acid | small-molecule | No | No | Zhao C, Wang H, Liu Y, Cheng L, Wang B, Tian X, Fu H, Wu C, Li Z, Shen C, Yu J, Yang S, Hu H, Fu P, Ma L, Wang C, Yan W, Shao Z | 10.1016/J.MOLCEL.2023.07.030 | 2023-09-06 | Yes | |
| HCAR2 | HCA2 | Hydroxycarboxylic acid | A | Human | Cryo-EM | 8JHY | - | 2.9 | A | Active | 100 | 80 | Gi/o | αi1 | - | 64 | - | scFv16 |
compound 9n [PMID: 18752940]
|
small-molecule | PAM | butyric acid, β-D-hydroxybutyric acid | small-molecule | No | No | Zhao C, Wang H, Liu Y, Cheng L, Wang B, Tian X, Fu H, Wu C, Li Z, Shen C, Yu J, Yang S, Hu H, Fu P, Ma L, Wang C, Yan W, Shao Z | 10.1016/J.MOLCEL.2023.07.030 | 2023-09-06 | Yes | |
| HCAR2 | HCA2 | Hydroxycarboxylic acid | A | Human | Cryo-EM | 8JIL | - | 3.5 | A | Active | 100 | 79 | Gi/o | αi1 | - | 63 | - | scFv16 |
nicotinic acid
|
small-molecule | Agonist | butyric acid, β-D-hydroxybutyric acid | small-molecule | No | No | Zhao C, Wang H, Liu Y, Cheng L, Wang B, Tian X, Fu H, Wu C, Li Z, Shen C, Yu J, Yang S, Hu H, Fu P, Ma L, Wang C, Yan W, Shao Z | 10.1016/J.MOLCEL.2023.07.030 | 2023-09-06 | Yes | |
| AA2AR | A2A | Adenosine | A | Human | X-ray | 8A2P | - | 3.5 | A | Inactive | 1 | 71 | - | - | - | - | BRIL | - |
CHEMBL1671936
|
small-molecule | Antagonist | adenosine | small-molecule | No | No | Birch J, Kwan TOC, Judge PJ, Axford D, Aller P, Butryn A, Reis RI, Bada Juarez JF, Vinals J, Owen RL, Nango E, Tanaka R, Tono K, Joti Y, Tanaka T, Owada S, Sugahara M, Iwata S, Orville AM, Watts A, Moraes I | 10.1107/S1600576723006428 | 2023-08-30 | Yes | |
| AA2AR | A2A | Adenosine | A | Human | X-ray | 8A2O | - | 3.5 | A | Inactive | 1 | 71 | - | - | - | - | BRIL | - |
theophylline
|
small-molecule | Antagonist | adenosine | small-molecule | No | No | Birch J, Kwan TOC, Judge PJ, Axford D, Aller P, Butryn A, Reis RI, Bada Juarez JF, Vinals J, Owen RL, Nango E, Tanaka R, Tono K, Joti Y, Tanaka T, Owada S, Sugahara M, Iwata S, Orville AM, Watts A, Moraes I | 10.1107/S1600576723006428 | 2023-08-30 | Yes | |
| HCAR2 | HCA2 | Hydroxycarboxylic acid | A | Human | Cryo-EM | 8IHI | - | 3.1 | R | Active | 100 | 80 | Gi/o | αi1 | - | 62 | BRIL | scFv16 |
(5S)-5-methyl-4-oxo-5-phenylfuran-2-carboxylic acid
|
small-molecule | Agonist | butyric acid, β-D-hydroxybutyric acid | small-molecule | No | No | Suzuki S, Tanaka K, Nishikawa K, Suzuki H, Oshima A, Fujiyoshi Y | 10.1038/S41467-023-41650-7 | 2023-08-30 | Yes | |
| HCAR2 | HCA2 | Hydroxycarboxylic acid | A | Human | Cryo-EM | 8IHF | - | 3.0 | R | Active | 100 | 80 | Gi/o | αi1 | - | 62 | BRIL | scFv16 |
MK 6892
|
small-molecule | Agonist | butyric acid, β-D-hydroxybutyric acid | small-molecule | No | No | Suzuki S, Tanaka K, Nishikawa K, Suzuki H, Oshima A, Fujiyoshi Y | 10.1038/S41467-023-41650-7 | 2023-08-30 | Yes | |
| HCAR2 | HCA2 | Hydroxycarboxylic acid | A | Human | Cryo-EM | 8IHH | - | 3.1 | R | Active | 100 | 80 | Gi/o | αi1 | - | 62 | BRIL | scFv16 |
5-butyl-1H-pyrazole-3-carboxylic acid
|
small-molecule | Agonist | butyric acid, β-D-hydroxybutyric acid | small-molecule | No | No | Suzuki S, Tanaka K, Nishikawa K, Suzuki H, Oshima A, Fujiyoshi Y | 10.1038/S41467-023-41650-7 | 2023-08-30 | Yes | |
| HCAR3 | HCA3 | Hydroxycarboxylic acid | A | Human | Cryo-EM | 8IHK | - | 3.2 | R | Active | 99 | 73 | - | - | - | - | BRIL | - |
(5S)-5-methyl-4-oxo-5-phenylfuran-2-carboxylic acid
|
small-molecule | Agonist | 3-hydroxyoctanoic acid | small-molecule | No | No | Suzuki S, Tanaka K, Nishikawa K, Suzuki H, Oshima A, Fujiyoshi Y | 10.1038/S41467-023-41650-7 | 2023-08-30 | Yes | |
| HCAR3 | HCA3 | Hydroxycarboxylic acid | A | Human | Cryo-EM | 8IHJ | 8IHJ_refined | 3.1 | R | Active | 100 | 73 | Gi/o | αi1 | - | 62 | BRIL | scFv16 |
(5S)-5-methyl-4-oxo-5-phenylfuran-2-carboxylic acid
|
small-molecule | Agonist | 3-hydroxyoctanoic acid | small-molecule | No | No | Suzuki S, Tanaka K, Nishikawa K, Suzuki H, Oshima A, Fujiyoshi Y | 10.1038/S41467-023-41650-7 | 2023-08-30 | Yes | |
| OPSD | Rhodopsin | Opsins | A | Bovine | X-ray | 8FD1 | - | 4.3 | A | Inactive | 24 | 88 | - | - | - | - | - | Nanobody-2 |
Apo (no ligand)
|
none | Apo (no ligand) | - | - | No | No | Wu A, Salom D, Hong JD, Tworak A, Watanabe K, Pardon E, Steyaert J, Kandori H, Katayama K, Kiser PD, Palczewski K | 10.1038/S41467-023-40911-9 | 2023-08-30 | Yes | |
| OPSD | Rhodopsin | Opsins | A | Bovine | X-ray | 8FD0 | - | 3.7 | A | Inactive | 24 | 89 | - | - | - | - | - | Nanobody-2 |
Apo (no ligand)
|
none | Apo (no ligand) | - | - | No | No | Wu A, Salom D, Hong JD, Tworak A, Watanabe K, Pardon E, Steyaert J, Kandori H, Katayama K, Kiser PD, Palczewski K | 10.1038/S41467-023-40911-9 | 2023-08-30 | Yes | |
| OPSD | Rhodopsin | Opsins | A | Bovine | X-ray | 8FCZ | - | 3.7 | A | Inactive | 24 | 89 | - | - | - | - | - | Nanobody-2 |
Retinal (11-cis)
|
small-molecule | Inverse agonist | - | - | No | No | Wu A, Salom D, Hong JD, Tworak A, Watanabe K, Pardon E, Steyaert J, Kandori H, Katayama K, Kiser PD, Palczewski K | 10.1038/S41467-023-40911-9 | 2023-08-30 | Yes | |
| AA2AR | A2A | Adenosine | A | Human | X-ray | 8JWZ | - | 2.4 | A | Inactive | 1 | 71 | - | - | - | - | T4-Lysozyme | - |
AB928
|
small-molecule | Antagonist | adenosine | small-molecule | No | No | - | - | 2023-08-16 | Yes | |
| AA2AR | A2A | Adenosine | A | Human | X-ray | 8JWY | - | 2.3 | A | Inactive | 1 | 70 | - | - | - | - | T4-Lysozyme | - |
CHEMBL5440290
|
small-molecule | Antagonist | adenosine | small-molecule | No | No | - | - | 2023-08-16 | Yes | |
| ADA1A | α1A | Adrenoceptors | A | Human | Cryo-EM | 8THL | - | 3.1 | R | Active | 100 | 52 | Gq/11 | αq | - | 57 | T4-Lysozyme | scFv16 |
(-)-adrenaline
|
small-molecule | Agonist | (-)-adrenaline, (-)-noradrenaline | small-molecule | No | No | Su M, Wang J, Xiang G, Do HN, Levitz J, Miao Y, Huang XY | 10.1038/S41467-023-40524-2 | 2023-08-16 | Yes | |
| ADA1A | α1A | Adrenoceptors | A | Human | Cryo-EM | 8THK | - | 2.6 | R | Active | 100 | 52 | Gq/11 | αq | - | 57 | T4-Lysozyme | scFv16 |
CHEMBL133451
|
small-molecule | Agonist | (-)-adrenaline, (-)-noradrenaline | small-molecule | No | No | Su M, Wang J, Xiang G, Do HN, Levitz J, Miao Y, Huang XY | 10.1038/S41467-023-40524-2 | 2023-08-16 | Yes | |
| EDNRB | ETB | Endothelin | A | Human | Cryo-EM | 8IY5 | - | 2.8 | R | Active | 100 | 71 | Gi/o | αi1 | - | 62 | - | scFv16 |
ENDOTHELIN
|
protein | Agonist | endothelin-2, endothelin-3, endothelin-1 | peptide | No | No | Sano FK, Akasaka H, Shihoya W, Nureki O | 10.7554/ELIFE.85821 | 2023-08-16 | Yes | |
| EDNRB | ETB | Endothelin | A | Human | Cryo-EM | 8IY6 | - | 3.1 | R | Active | 83 | 66 | - | - | - | - | - | - |
ENDOTHELIN
|
protein | Agonist | endothelin-2, endothelin-3, endothelin-1 | peptide | No | No | Sano FK, Akasaka H, Shihoya W, Nureki O | 10.7554/ELIFE.85821 | 2023-08-16 | Yes | |
| GLR | glucagon | Glucagon | B1 | Human | Cryo-EM | 8JRU | - | 3.5 | R | Active | 100 | 53 | Beta | Beta-arrestin-1 | - | 83 | - | scFv30 Nanobody-32 |
Apo (no ligand)
|
none | Apo (no ligand) | glucagon | peptide | No | No | Chen K, Zhang C, Lin S, Yan X, Cai H, Yi C, Ma L, Chu X, Liu Y, Zhu Y, Han S, Zhao Q, Wu B | 10.1038/S41586-023-06420-X | 2023-08-16 | Yes | |
| GLR | glucagon | Glucagon | B1 | Human | Cryo-EM | 8JRV | - | 3.3 | R | Active | 100 | 64 | Beta | Beta-arrestin-1 | - | 85 | - | scFv30 Nanobody-32 |
glucagon
|
peptide | Agonist | glucagon | peptide | No | No | Chen K, Zhang C, Lin S, Yan X, Cai H, Yi C, Ma L, Chu X, Liu Y, Zhu Y, Han S, Zhao Q, Wu B | 10.1038/S41586-023-06420-X | 2023-08-16 | Yes | |
| GRPR | BB2 | Bombesin | A | Human | Cryo-EM | 8H0Q | - | 3.3 | R | Active | 100 | 77 | Gq/11 | αq | - | 56 | - | - |
Gastrin-releasing peptide
|
peptide | Agonist | gastrin-releasing peptide, neuromedin B, neuromedin C, gastrin releasing peptide(14-27) (human), GRP-(18-27) | peptide | No | No | Li C, Xu Y, Liu H, Cai H, Jiang Y, Xu HE, Yin W | 10.1038/S41422-022-00743-6 | 2023-08-09 | Yes | |
| NMBR | BB1 | Bombesin | A | Human | Cryo-EM | 8H0P | - | 3.2 | R | Active | 100 | 75 | Gq/11 | αq | - | 57 | - | scFv16 |
NMB30
|
peptide | Agonist | gastrin-releasing peptide, neuromedin B, gastrin releasing peptide(14-27) (human), GRP-(18-27) | peptide | No | No | Li C, Xu Y, Liu H, Cai H, Jiang Y, Xu HE, Yin W | 10.1038/S41422-022-00743-6 | 2023-08-09 | Yes | |
| NTR1 | NTS1 | Neurotensin | A | Human | Cryo-EM | 8JPF | - | 3.0 | R | Active | 83 | 71 | - | - | - | - | - | - |
JMV431
CHEMBL4576388 |
peptide small-molecule |
Agonist PAM |
large neurotensin, neurotensin, neuromedin N, large neuromedin N | peptide | No | No | Duan J, Liu H, Zhao F, Yuan Q, Ji Y, Cai X, He X, Li X, Li J, Wu K, Gao T, Zhu S, Lin S, Wang MW, Cheng X, Yin W, Jiang Y, Yang D, Xu HE | 10.1038/S41586-023-06395-9 | 2023-08-09 | Yes | |
| NTR1 | NTS1 | Neurotensin | A | Human | Cryo-EM | 8JPB | - | 3.1 | R | Active | 100 | 71 | Gq/11 | αq | GRK2 bound | 88 | - | GRK2 |
JMV431
CHEMBL4576388 |
peptide small-molecule |
Agonist PAM |
large neurotensin, neurotensin, neuromedin N, large neuromedin N | peptide | No | No | Duan J, Liu H, Zhao F, Yuan Q, Ji Y, Cai X, He X, Li X, Li J, Wu K, Gao T, Zhu S, Lin S, Wang MW, Cheng X, Yin W, Jiang Y, Yang D, Xu HE | 10.1038/S41586-023-06395-9 | 2023-08-09 | Yes | |
| NTR1 | NTS1 | Neurotensin | A | Human | Cryo-EM | 8JPC | - | 3.1 | R | Active | 100 | 71 | Gq/11 | αq | GRK2 bound | 88 | - | GRK2 |
JMV431
CHEMBL4576388 |
peptide small-molecule |
Agonist PAM |
large neurotensin, neurotensin, neuromedin N, large neuromedin N | peptide | No | No | Duan J, Liu H, Zhao F, Yuan Q, Ji Y, Cai X, He X, Li X, Li J, Wu K, Gao T, Zhu S, Lin S, Wang MW, Cheng X, Yin W, Jiang Y, Yang D, Xu HE | 10.1038/S41586-023-06395-9 | 2023-08-09 | Yes | |
| TAA7F | TAAR7F | A orphans | A | Mouse | Cryo-EM | 8PM2 | - | 2.9 | R | Active | 100 | 73 | Gs | αs | - | 58 | - | Nanobody-35 |
N,N-Dimethylcyclohexylamine
|
small-molecule | Agonist | - | - | No | No | Gusach A, Lee Y, Khoshgrudi AN, Mukhaleva E, Ma N, Koers EJ, Chen Q, Edwards PC, Huang F, Kim J, Mancia F, Verprintsev DB, Vaidehi N, Weyand SN, Tate CG | 10.1101/2023.07.07.547762 | 2023-08-09 | Yes | |
| CALCR | CT | Calcitonin | B1 | Human | Cryo-EM | 8F0J | - | 2.0 | R | Active | 100 | 78 | Gs | αs | - | 58 | - | Nanobody-35 |
Pramlintide analogue San45
|
peptide | Agonist | adrenomedullin, calcitonin, β-CGRP, adrenomedullin 2/intermedin, α-CGRP, amylin | peptide | No | No | Cao J, Belousoff MJ, Gerrard E, Danev R, Fletcher MM, Dal Maso E, Schreuder H, Lorenz K, Evers A, Tiwari G, Besenius M, Li Z, Johnson RM, Wootten D, Sexton PM | 10.1038/S41589-023-01393-4 | 2023-08-02 | Yes | |
| CALCR | CT | Calcitonin | B1 | Human | Cryo-EM | 8F0K | - | 1.9 | R | Active | 100 | 78 | Gs | αs | - | 58 | - | Nanobody-35 RAMP3 |
San385
|
peptide | Agonist | adrenomedullin, calcitonin, β-CGRP, adrenomedullin 2/intermedin, α-CGRP, amylin | peptide | No | No | Cao J, Belousoff MJ, Gerrard E, Danev R, Fletcher MM, Dal Maso E, Schreuder H, Lorenz K, Evers A, Tiwari G, Besenius M, Li Z, Johnson RM, Wootten D, Sexton PM | 10.1038/S41589-023-01393-4 | 2023-08-02 | Yes | |
| CALCR | CT | Calcitonin | B1 | Human | Cryo-EM | 8F2B | - | 2.0 | R | Active | 100 | 78 | Gs | αs | - | 58 | - | Nanobody-35 RAMP3 |
Pramlintide analogue San45
|
peptide | Agonist | adrenomedullin, calcitonin, β-CGRP, adrenomedullin 2/intermedin, α-CGRP, amylin | peptide | No | No | Cao J, Belousoff MJ, Gerrard E, Danev R, Fletcher MM, Dal Maso E, Schreuder H, Lorenz K, Evers A, Tiwari G, Besenius M, Li Z, Johnson RM, Wootten D, Sexton PM | 10.1038/S41589-023-01393-4 | 2023-08-02 | Yes | |
| CALCR | CT | Calcitonin | B1 | Human | Cryo-EM | 8F2A | - | 2.2 | R | Active | 100 | 78 | Gs | αs | - | 59 | - | Nanobody-35 |
Pramlintide analogue San385
|
peptide | Agonist | adrenomedullin, calcitonin, β-CGRP, adrenomedullin 2/intermedin, α-CGRP, amylin | peptide | No | No | Cao J, Belousoff MJ, Gerrard E, Danev R, Fletcher MM, Dal Maso E, Schreuder H, Lorenz K, Evers A, Tiwari G, Besenius M, Li Z, Johnson RM, Wootten D, Sexton PM | 10.1038/S41589-023-01393-4 | 2023-08-02 | Yes | |
| PTH1R | PTH1 | Parathyroid hormone | B1 | Human | Cryo-EM | 8JR9 | - | 2.6 | R | Active | 100 | 43 | Gs | αs | - | 59 | - | Nanobody-35 |
PCO371
|
small-molecule | Agonist | PTH, PTHrP, TIP39, PTHrP-(1-36) | peptide | No | No | Zhao LH, He Q, Yuan Q, Gu Y, He X, Shan H, Li J, Wang K, Li Y, Hu W, Wu K, Shen J, Xu HE | 10.1038/S41586-023-06467-W | 2023-08-02 | Yes | |
| CXCR1 | CXCR1 | Chemokine | A | Human | Cryo-EM | 8IC0 | - | 3.4 | A | Active | 100 | 86 | Gi/o | αi1 | - | 65 | - | scFv16 |
Interleukin-8
|
protein | Agonist | CXCL6, CXCL8, cytokine domain of tyrosyl tRNA synthetase | peptide | No | No | Ishimoto N, Park JH, Kawakami K, Tajiri M, Mizutani K, Akashi S, Tame JRH, Inoue A, Park SY | 10.1038/S41467-023-39799-2 | 2023-07-19 | Yes | |
| AA2AR | A2A | Adenosine | A | Human | X-ray | 8C9W | - | 2.1 | A | Inactive | 1 | 72 | - | - | - | - | BRIL | - |
AB928
|
small-molecule | Antagonist | adenosine | small-molecule | No | No | Claff T, Schlegel JG, Voss JH, Vaassen VJ, Weisse RH, Cheng RKY, Markovic-Mueller S, Bucher D, Strater N, Muller CE | 10.1038/S42004-023-00894-6 | 2023-07-12 | Yes | |
| AGRE5 | ADGRE5 | ADGRE | B2 | Human | Cryo-EM | 7YDJ | - | 3.0 | R | Active | 100 | 33 | G12/13 | α12 | Mini-G12 | 55 | - | scFv16 |
Apo (no ligand)
|
none | Apo (no ligand) | - | - | No | No | - | - | 2023-07-12 | Yes | |
| AGRE5 | ADGRE5 | ADGRE | B2 | Human | Cryo-EM | 7YDM | - | 2.9 | R | Active | 100 | 33 | Gq/11 | αq | Mini-Gq | 60 | - | Nanobody-35 |
Apo (no ligand)
|
none | Apo (no ligand) | - | - | No | No | Wang N, Qian Y, Xia R, Zhu X, Xiong Y, Zhang A, Guo C, He Y | 10.1016/J.CHEMBIOL.2023.08.003 | 2023-07-12 | Yes | |
| AGRE5 | ADGRE5 | ADGRE | B2 | Human | Cryo-EM | 7YDP | - | 3.1 | R | Active | 100 | 32 | Gs | αs | Mini-Gs | 59 | - | Nanobody-35 |
Apo (no ligand)
|
none | Apo (no ligand) | - | - | No | No | Wang N, Qian Y, Xia R, Zhu X, Xiong Y, Zhang A, Guo C, He Y | 10.1016/J.CHEMBIOL.2023.08.003 | 2023-07-12 | Yes | |
| AGRE5 | ADGRE5 | ADGRE | B2 | Human | Cryo-EM | 7YDH | - | 3.1 | R | Active | 100 | 33 | G12/13 | α13 | Gi2-mini-G13 chimera | 57 | - | scFv16 |
Apo (no ligand)
|
none | Apo (no ligand) | - | - | No | No | Wang N, Qian Y, Xia R, Zhu X, Xiong Y, Zhang A, Guo C, He Y | 10.1016/J.CHEMBIOL.2023.08.003 | 2023-07-12 | Yes | |
| PF2R | FP | Prostanoid | A | Human | Cryo-EM | 8IUM | - | 3.1 | R | Active | 100 | 82 | Gq/11 | αq | - | 60 | - | scFv16 Nanobody-35 |
tafluprost acid
|
small-molecule | Agonist | PGF2α, PGI2, PGE2, thromboxane A2, PGD2 | small-molecule | No | No | Wu C, Xu Y, He Q, Li D, Duan J, Li C, You C, Chen H, Fan W, Jiang Y, Eric Xu H | 10.1038/S41467-023-38411-X | 2023-07-12 | Yes | |
| PF2R | FP | Prostanoid | A | Human | Cryo-EM | 8IUL | - | 2.8 | R | Active | 100 | 82 | Gq/11 | αq | - | 60 | - | scFv16 |
latanoprost (free acid form)
|
small-molecule | Agonist | PGF2α, PGI2, PGE2, thromboxane A2, PGD2 | small-molecule | No | No | Wu C, Xu Y, He Q, Li D, Duan J, Li C, You C, Chen H, Fan W, Jiang Y, Eric Xu H | 10.1038/S41467-023-38411-X | 2023-07-12 | Yes | |
| PF2R | FP | Prostanoid | A | Human | Cryo-EM | 8IUK | - | 2.7 | R | Active | 100 | 82 | Gq/11 | αq | - | 60 | - | scFv16 Nanobody-35 |
PGF2α
|
small-molecule | Agonist | PGF2α, PGI2, PGE2, thromboxane A2, PGD2 | small-molecule | No | No | Wu C, Xu Y, He Q, Li D, Duan J, Li C, You C, Chen H, Fan W, Jiang Y, Eric Xu H | 10.1038/S41467-023-38411-X | 2023-07-12 | Yes | |
| ADA1A | α1A | Adrenoceptors | A | Human | Cryo-EM | 7YMJ | - | 3.4 | A | Inactive | 8 | 60 | - | - | - | - | - | Nanobody-6 |
tamsulosin
|
small-molecule | Antagonist | (-)-adrenaline, (-)-noradrenaline | small-molecule | No | No | Toyoda Y, Zhu A, Kong F, Shan S, Zhao J, Wang N, Sun X, Zhang L, Yan C, Kobilka BK, Liu X | 10.1038/S41467-023-39310-X | 2023-07-05 | Yes | |
| ADA1A | α1A | Adrenoceptors | A | Human | Cryo-EM | 7YMH | 7YMH_refined | 3.5 | A | Active | 100 | 58 | Gq/11 | αq | Mini-Gq | 51 | - | Nanobody-29 |
Noradrenaline
|
small-molecule | Agonist | (-)-adrenaline, (-)-noradrenaline | small-molecule | No | No | Toyoda Y, Zhu A, Kong F, Shan S, Zhao J, Wang N, Sun X, Zhang L, Yan C, Kobilka BK, Liu X | 10.1038/S41467-023-39310-X | 2023-07-05 | Yes | |
| ADA1A | α1A | Adrenoceptors | A | Human | Cryo-EM | 7YM8 | 7YM8_refined | 2.9 | A | Active | 100 | 58 | Gq/11 | αq | Mini-Gq | 46 | - | Nanobody-29 |
oxymetazoline
|
small-molecule | Agonist | (-)-adrenaline, (-)-noradrenaline | small-molecule | No | No | Toyoda Y, Zhu A, Kong F, Shan S, Zhao J, Wang N, Sun X, Zhang L, Yan C, Kobilka BK, Liu X | 10.1038/S41467-023-39310-X | 2023-07-05 | Yes | |
| PTH1R | PTH1 | Parathyroid hormone | B1 | Human | Cryo-EM | 7Y36 | - | 2.8 | R | Active | 100 | 63 | Gs | αs | - | 57 | - | Nanobody-35 |
Parathyroid hormone
|
peptide | Agonist | PTH, PTHrP, TIP39, PTHrP-(1-36) | peptide | No | No | - | - | 2023-07-05 | Yes | |
| PTH1R | PTH1 | Parathyroid hormone | B1 | Human | Cryo-EM | 7Y35 | - | 2.9 | R | Active | 100 | 63 | Gs | αs | - | 57 | - | Nanobody-35 |
abaloparatide
|
small-molecule | Agonist | PTH, PTHrP, TIP39, PTHrP-(1-36) | peptide | No | No | - | - | 2023-07-05 | Yes | |
| 5HT6R | 5-HT6 | 5-Hydroxytryptamine | A | Human | Cryo-EM | 8JLZ | - | 3.1 | R | Active | 100 | 61 | Gs | αs | - | 58 | - | Nanobody-35 |
CHEMBL365751
|
small-molecule | Agonist | 5-hydroxytryptamine | small-molecule | No | No | Pei Y, Wen X, Guo SC, Yang ZS, Zhang R, Xiao P, Sun JP | 10.1016/J.BBRC.2023.05.126 | 2023-06-28 | Yes | |
| DRD1 | D1 | Dopamine | A | Human | Cryo-EM | 8IRR | - | 3.2 | R | Active | 100 | 63 | Gs | αs | Mini-Gs | 57 | - | Nanobody-35 |
rotigotine
|
small-molecule | Agonist | noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, dopamine, 5-hydroxytryptamine | small-molecule | No | No | Xu P, Huang S, Krumm BE, Zhuang Y, Mao C, Zhang Y, Wang Y, Huang XP, Liu YF, He X, Li H, Yin W, Jiang Y, Zhang Y, Roth BL, Xu HE | 10.1038/S41422-023-00808-0 | 2023-06-21 | Yes | |
| DRD4 | D4 | Dopamine | A | Human | Cryo-EM | 8IRU | - | 3.2 | R | Active | 100 | 64 | Gi/o | αi1 | - | 60 | - | scFv16 |
rotigotine
|
small-molecule | Agonist | dopamine | small-molecule | No | No | Xu P, Huang S, Krumm BE, Zhuang Y, Mao C, Zhang Y, Wang Y, Huang XP, Liu YF, He X, Li H, Yin W, Jiang Y, Zhang Y, Roth BL, Xu HE | 10.1038/S41422-023-00808-0 | 2023-06-21 | Yes | |
| FFAR4 | FFA4 | Free fatty acid | A | Human | Cryo-EM | 8H4I | - | 3.1 | R | Active | 100 | 78 | Gs | αs | - | 59 | - | Nanobody-35 |
docosahexaenoic acid
|
small-molecule | Agonist | oleic acid, myristic acid, linoleic acid, α-linolenic acid | small-molecule | No | No | Yin H, Inoue A, Ma Z, Zhu X, Xia R, Xu Z, Wang N, Duan Y, Zhang A, Guo C, He Y | 10.1038/S41422-023-00835-X | 2023-06-21 | Yes | |
| FFAR4 | FFA4 | Free fatty acid | A | Human | Cryo-EM | 8IYS | - | 3.0 | R | Active | 100 | 82 | Gq/11 | αq | - | 99 | - | scFv16 |
TUG-891
|
small-molecule | Agonist | oleic acid, myristic acid, linoleic acid, α-linolenic acid | small-molecule | No | No | Yin H, Inoue A, Ma Z, Zhu X, Xia R, Xu Z, Wang N, Duan Y, Zhang A, Guo C, He Y | 10.1038/S41422-023-00835-X | 2023-06-21 | Yes | |
| FFAR4 | FFA4 | Free fatty acid | A | Human | Cryo-EM | 8H4L | - | 3.1 | R | Active | 100 | 84 | Gq/11 | αq | - | 60 | - | Nanobody-35 |
docosahexaenoic acid
|
small-molecule | Agonist | oleic acid, myristic acid, linoleic acid, α-linolenic acid | small-molecule | No | No | Yin H, Inoue A, Ma Z, Zhu X, Xia R, Xu Z, Wang N, Duan Y, Zhang A, Guo C, He Y | 10.1038/S41422-023-00835-X | 2023-06-21 | Yes | |
| FFAR4 | FFA4 | Free fatty acid | A | Human | Cryo-EM | 8H4K | - | 3.1 | R | Active | 100 | 83 | Gq/11 | αq | Mini-Gq | 60 | - | Nanobody-35 |
GW9508
|
small-molecule | Agonist | oleic acid, myristic acid, linoleic acid, α-linolenic acid | small-molecule | No | No | Yin H, Inoue A, Ma Z, Zhu X, Xia R, Xu Z, Wang N, Duan Y, Zhang A, Guo C, He Y | 10.1038/S41422-023-00835-X | 2023-06-21 | Yes | |
| GPR52 | GPR52 | A orphans | A | Human | Cryo-EM | 8HMP | - | 2.8 | R | Active | 100 | 79 | Gs | αs | - | 61 | - | Nanobody-35 |
derivative 17 [Nakahata et al., 2018]
|
small-molecule | Agonist | - | - | No | No | Fan Y, Lin X, Pan B, Chen B, Liu D, Wuthrich K, Xu F | 10.1002/MCO2.260 | 2023-06-21 | Yes | |
| GPR84 | GPR84 | A orphans | A | Human | Cryo-EM | 8J1A | - | 3.2 | R | Active | 100 | 73 | Gi/o | αi1 | - | 62 | - | scFv16 |
Apo (no ligand)
|
none | Apo (no ligand) | - | - | No | No | Liu H, Zhang Q, He X, Jiang M, Wang S, Yan X, Cheng X, Liu Y, Nan FJ, Xu HE, Xie X, Yin W | 10.1038/S41467-023-38985-6 | 2023-06-21 | Yes | |
| GPR84 | GPR84 | A orphans | A | Human | Cryo-EM | 8J18 | - | 2.9 | R | Active | 100 | 73 | Gi/o | αi1 | - | 62 | - | scFv16 |
(3R)-3-HYDROXYDODECANOIC ACID
|
small-molecule | Agonist | - | - | No | No | Liu H, Zhang Q, He X, Jiang M, Wang S, Yan X, Cheng X, Liu Y, Nan FJ, Xu HE, Xie X, Yin W | 10.1038/S41467-023-38985-6 | 2023-06-21 | Yes | |
| GPR84 | GPR84 | A orphans | A | Human | Cryo-EM | 8J19 | - | 3.2 | R | Active | 100 | 71 | Gi/o | αi1 | - | 62 | - | scFv16 |
6-nonylpyridine-2,4-diol
|
small-molecule | Agonist | - | - | No | No | Liu H, Zhang Q, He X, Jiang M, Wang S, Yan X, Cheng X, Liu Y, Nan FJ, Xu HE, Xie X, Yin W | 10.1038/S41467-023-38985-6 | 2023-06-21 | Yes | |
| GRM2 | mGlu2 | Metabotropic glutamate | C | Human | Cryo-EM | 8JCV | - | 3.4 | 2 | Inactive | - | 88 | - | - | - | - | - | - |
LY341495
|
small-molecule | Antagonist | L-glutamic acid | small-molecule | No | No | Wang X, Wang M, Xu T, Feng Y, Shao Q, Han S, Chu X, Xu Y, Lin S, Zhao Q, Wu B | 10.1038/S41422-023-00830-2 | 2023-06-21 | Yes | |
| GRM2 | mGlu2 | Metabotropic glutamate | C | Human | Cryo-EM | 8JD4 | - | 2.9 | 2 | Active | - | 84 | - | - | - | - | - | - |
L-glutamic acid
|
small-molecule | Agonist | L-glutamic acid | small-molecule | No | No | Wang X, Wang M, Xu T, Feng Y, Shao Q, Han S, Chu X, Xu Y, Lin S, Zhao Q, Wu B | 10.1038/S41422-023-00830-2 | 2023-06-21 | Yes | |
| GRM2 | mGlu2 | Metabotropic glutamate | C | Human | Cryo-EM | 8JCW | - | 3.0 | 2 | Inactive | - | 87 | - | - | - | - | - | - |
LY341495
|
small-molecule | Antagonist | L-glutamic acid | small-molecule | No | No | Wang X, Wang M, Xu T, Feng Y, Shao Q, Han S, Chu X, Xu Y, Lin S, Zhao Q, Wu B | 10.1038/S41422-023-00830-2 | 2023-06-21 | Yes | |
| GRM2 | mGlu2 | Metabotropic glutamate | C | Human | Cryo-EM | 8JD3 | - | 3.3 | 2 | Active | - | 89 | Gi/o | αi1 | - | 62 | - | - |
L-glutamic acid
JNJ-40411813 |
small-molecule small-molecule |
Agonist PAM |
L-glutamic acid | small-molecule | No | No | Wang X, Wang M, Xu T, Feng Y, Shao Q, Han S, Chu X, Xu Y, Lin S, Zhao Q, Wu B | 10.1038/S41422-023-00830-2 | 2023-06-21 | Yes | |
| GRM2 | mGlu2 | Metabotropic glutamate | C | Human | Cryo-EM | 8JCU | - | 2.8 | 2 | Inactive | - | 87 | - | - | - | - | - | - |
LY341495
|
small-molecule | Antagonist | L-glutamic acid | small-molecule | No | No | Wang X, Wang M, Xu T, Feng Y, Shao Q, Han S, Chu X, Xu Y, Lin S, Zhao Q, Wu B | 10.1038/S41422-023-00830-2 | 2023-06-21 | Yes | |
| GRM2 | mGlu2 | Metabotropic glutamate | C | Human | Cryo-EM | 8JD2 | - | 2.8 | 2 | Active | - | 86 | - | - | - | - | - | - |
L-glutamic acid
|
small-molecule | Agonist | L-glutamic acid | small-molecule | No | No | Wang X, Wang M, Xu T, Feng Y, Shao Q, Han S, Chu X, Xu Y, Lin S, Zhao Q, Wu B | 10.1038/S41422-023-00830-2 | 2023-06-21 | Yes | |
| GRM2 | mGlu2 | Metabotropic glutamate | C | Human | Cryo-EM | 8JD1 | - | 3.7 | 2 | Inactive | - | 86 | - | - | - | - | - | - |
L-glutamic acid
|
small-molecule | Agonist | L-glutamic acid | small-molecule | No | No | Wang X, Wang M, Xu T, Feng Y, Shao Q, Han S, Chu X, Xu Y, Lin S, Zhao Q, Wu B | 10.1038/S41422-023-00830-2 | 2023-06-21 | Yes | |
| GRM2 | mGlu2 | Metabotropic glutamate | C | Human | Cryo-EM | 8JD5 | - | 3.6 | 2 | Active | - | 90 | Gi/o | αi1 | - | 63 | - | scFv16 |
L-glutamic acid
ADX88178 JNJ-40411813 |
small-molecule small-molecule small-molecule |
Agonist | L-glutamic acid | small-molecule | No | No | Wang X, Wang M, Xu T, Feng Y, Shao Q, Han S, Chu X, Xu Y, Lin S, Zhao Q, Wu B | 10.1038/S41422-023-00830-2 | 2023-06-21 | Yes | |
| GRM2 | mGlu2 | Metabotropic glutamate | C | Human | Cryo-EM | 8JD0 | - | 3.3 | 2 | Inactive | - | 88 | - | - | - | - | - | - |
L-glutamic acid
CHEMBL3894759 |
small-molecule small-molecule |
Agonist NAM |
L-glutamic acid | small-molecule | No | No | Wang X, Wang M, Xu T, Feng Y, Shao Q, Han S, Chu X, Xu Y, Lin S, Zhao Q, Wu B | 10.1038/S41422-023-00830-2 | 2023-06-21 | Yes | |
| GRM2 | mGlu2 | Metabotropic glutamate | C | Human | Cryo-EM | 8JCX | - | 3.0 | 2 | Inactive | - | 87 | - | - | - | - | - | - |
LY341495
|
small-molecule | Antagonist | L-glutamic acid | small-molecule | No | No | Wang X, Wang M, Xu T, Feng Y, Shao Q, Han S, Chu X, Xu Y, Lin S, Zhao Q, Wu B | 10.1038/S41422-023-00830-2 | 2023-06-21 | Yes | |
| GRM2 | mGlu2 | Metabotropic glutamate | C | Human | Cryo-EM | 8JCY | - | 2.9 | 2 | Inactive | - | 87 | - | - | - | - | - | - |
LY341495
|
small-molecule | Antagonist | L-glutamic acid | small-molecule | No | No | Wang X, Wang M, Xu T, Feng Y, Shao Q, Han S, Chu X, Xu Y, Lin S, Zhao Q, Wu B | 10.1038/S41422-023-00830-2 | 2023-06-21 | Yes | |
| GRM2 | mGlu2 | Metabotropic glutamate | C | Human | Cryo-EM | 8JCZ | - | 3.0 | 2 | Inactive | - | 87 | - | - | - | - | - | - |
LY341495
|
small-molecule | Antagonist | L-glutamic acid | small-molecule | No | No | Wang X, Wang M, Xu T, Feng Y, Shao Q, Han S, Chu X, Xu Y, Lin S, Zhao Q, Wu B | 10.1038/S41422-023-00830-2 | 2023-06-21 | Yes | |
| GRM4 | mGlu4 | Metabotropic glutamate | C | Human | Cryo-EM | 8JD6 | - | 3.4 | S | Active | - | 83 | Gi/o | αi3 | - | 63 | - | scFv16 |
VU0364770
|
small-molecule | Agonist | L-serine-O-phosphate, L-glutamic acid | small-molecule | No | No | Wang X, Wang M, Xu T, Feng Y, Shao Q, Han S, Chu X, Xu Y, Lin S, Zhao Q, Wu B | 10.1038/S41422-023-00830-2 | 2023-06-21 | Yes | |
| PTH1R | PTH1 | Parathyroid hormone | B1 | Human | Cryo-EM | 8GW8 | - | 2.9 | R | Active | 100 | 37 | Gs | αs | - | 58 | - | Nanobody-35 |
PCO371
|
small-molecule | Agonist | PTH, PTHrP, TIP39, PTHrP-(1-36) | peptide | No | No | Kobayashi K, Kawakami K, Kusakizako T, Tomita A, Nishimura M, Sawada K, Okamoto HH, Hiratsuka S, Nakamura G, Kuwabara R, Noda H, Muramatsu H, Shimizu M, Taguchi T, Inoue A, Murata T, Nureki O | 10.1038/S41586-023-06169-3 | 2023-06-14 | Yes | |
| DRD2 | D2 | Dopamine | A | Human | Cryo-EM | 8IRS | - | 3.0 | R | Active | 100 | 60 | Gi/o | αi1 | - | 63 | BRIL | scFv16 |
rotigotine
|
small-molecule | Agonist | dopamine | small-molecule | No | No | Xu P, Huang S, Krumm BE, Zhuang Y, Mao C, Zhang Y, Wang Y, Huang XP, Liu YF, He X, Li H, Yin W, Jiang Y, Zhang Y, Roth BL, Xu HE | 10.1038/S41422-023-00808-0 | 2023-06-07 | Yes | |
| DRD3 | D3 | Dopamine | A | Human | Cryo-EM | 8IRT | - | 2.7 | R | Active | 100 | 68 | Gi/o | αi1 | - | 63 | BRIL | scFv16 |
rotigotine
|
small-molecule | Agonist | dopamine | small-molecule | No | No | Xu P, Huang S, Krumm BE, Zhuang Y, Mao C, Zhang Y, Wang Y, Huang XP, Liu YF, He X, Li H, Yin W, Jiang Y, Zhang Y, Roth BL, Xu HE | 10.1038/S41422-023-00808-0 | 2023-06-07 | Yes | |
| DRD5 | D5 | Dopamine | A | Human | Cryo-EM | 8IRV | 8IRV_refined | 3.1 | R | Active | 100 | 58 | Gs | αs | - | 60 | BRIL | - |
rotigotine
|
small-molecule | Agonist | noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, dopamine, 5-hydroxytryptamine | small-molecule | No | No | Xu P, Huang S, Krumm BE, Zhuang Y, Mao C, Zhang Y, Wang Y, Huang XP, Liu YF, He X, Li H, Yin W, Jiang Y, Zhang Y, Roth BL, Xu HE | 10.1038/S41422-023-00808-0 | 2023-06-07 | Yes | |
| GPR12 | GPR12 | A orphans | A | Human | Cryo-EM | 7Y3G | 7Y3G_refined | 2.8 | R | Active | 100 | 78 | Gs | αs | - | 56 | - | Nanobody-35 |
Apo (no ligand)
|
none | Apo (no ligand) | sphingosine 1-phosphate | small-molecule | No | No | Li H, Zhang J, Yu Y, Luo F, Wu L, Liu J, Chen N, Liu Z, Hua T | 10.1016/J.SCIB.2022.12.023 | 2023-06-07 | Yes | |
| P2RY1 | P2Y1 | P2Y | A | Human | Cryo-EM | 7XXH | 7XXH_refined | 2.9 | R | Active | 100 | 81 | Gq/11 | α11 | - | 63 | - | scFv16 |
2MeSADP
|
small-molecule | Agonist | ADP, ATP | small-molecule | No | No | - | - | 2023-06-07 | Yes | |
| P2Y12 | P2Y12 | P2Y | A | Human | Cryo-EM | 7XXI | 7XXI_refined | 3.0 | A | Active | 100 | 86 | Gi/o | αi2 | - | 61 | - | - |
2MeSADP
|
small-molecule | Agonist | ADP, ATP | small-molecule | No | No | - | - | 2023-06-07 | Yes | |
| AA2AR | A2A | Adenosine | A | Human | X-ray | 8CIC | - | 2.1 | A | Inactive | 1 | 71 | - | - | - | - | BRIL | - |
AB928
|
small-molecule | Antagonist | adenosine | small-molecule | No | No | Claff T, Schlegel JG, Voss JH, Vaassen VJ, Weisse RH, Cheng RKY, Markovic-Mueller S, Bucher D, Strater N, Muller CE | 10.1038/S42004-023-00894-6 | 2023-05-31 | Yes | |
| MRGX1 | MRGPRX1 | A orphans | A | Human | Cryo-EM | 8HJ5 | 8HJ5_refined | 3.0 | F | Active | 100 | 78 | Gq/11 | αq | - | 60 | BRIL | scFv16 Nanobody-35 |
compound 16 [PMID: 31498617]
|
small-molecule | Agonist | bovine adrenal medulla peptide 8-22 | peptide | No | No | - | - | 2023-05-31 | Yes | |
| NK2R | NK2 | Tachykinin | A | Human | Cryo-EM | 7XWO | 7XWO_refined | 2.7 | B | Active | 100 | 68 | Gq/11 | αq | - | 59 | BRIL | scFv16 |
HIS-LYS-THR-ASP-SER-PHE-VAL-GLY-LEU-MET-NH2
|
peptide | Agonist | neurokinin A, neuropeptide K, hemokinin 1, neurokinin B, neuropeptide γ, substance P | peptide | No | No | - | - | 2023-05-31 | Yes | |
| TAAR9 | TAAR9 | A orphans | A | Mouse | Cryo-EM | 8IW7 | - | 3.0 | R | Active | 100 | 78 | Gs | αs | - | 59 | - | scFv16 |
2-Phenylethanaminium
|
small-molecule | Agonist | - | - | No | No | Guo L, Cheng J, Lian S, Liu Q, Lu Y, Zheng Y, Zhu K, Zhang M, Kong Y, Zhang C, Rong N, Zhuang Y, Fang G, Jiang J, Zhang T, Han X, Liu Z, Xia M, Liu S, Zhang L, Liberles SD, Yu X, Xu Y, Yang F, Li Q, Sun JP | 10.1038/S41586-023-06106-4 | 2023-05-31 | Yes | |
| TAAR9 | TAAR9 | A orphans | A | Mouse | Cryo-EM | 8IWM | - | 3.2 | R | Active | 96 | 78 | - | - | - | - | - | - |
2-Phenylethanaminium
|
small-molecule | Agonist | - | - | No | No | Guo L, Cheng J, Lian S, Liu Q, Lu Y, Zheng Y, Zhu K, Zhang M, Kong Y, Zhang C, Rong N, Zhuang Y, Fang G, Jiang J, Zhang T, Han X, Liu Z, Xia M, Liu S, Zhang L, Liberles SD, Yu X, Xu Y, Yang F, Li Q, Sun JP | 10.1038/S41586-023-06106-4 | 2023-05-31 | Yes | |
| TAAR9 | TAAR9 | A orphans | A | Mouse | Cryo-EM | 8IW4 | - | 3.5 | R | Active | 100 | 85 | Gs | αs | - | 45 | - | scFv16 |
SPERMIDINE
|
small-molecule | Agonist | - | - | No | No | Guo L, Cheng J, Lian S, Liu Q, Lu Y, Zheng Y, Zhu K, Zhang M, Kong Y, Zhang C, Rong N, Zhuang Y, Fang G, Jiang J, Zhang T, Han X, Liu Z, Xia M, Liu S, Zhang L, Liberles SD, Yu X, Xu Y, Yang F, Li Q, Sun JP | 10.1038/S41586-023-06106-4 | 2023-05-31 | Yes | |
| TAAR9 | TAAR9 | A orphans | A | Mouse | Cryo-EM | 8IW1 | - | 3.4 | R | Active | 100 | 78 | Gs | αolf | Golf-Gi chimera | 59 | - | scFv16 |
2-Phenylethanaminium
|
small-molecule | Agonist | - | - | No | No | Guo L, Cheng J, Lian S, Liu Q, Lu Y, Zheng Y, Zhu K, Zhang M, Kong Y, Zhang C, Rong N, Zhuang Y, Fang G, Jiang J, Zhang T, Han X, Liu Z, Xia M, Liu S, Zhang L, Liberles SD, Yu X, Xu Y, Yang F, Li Q, Sun JP | 10.1038/S41586-023-06106-4 | 2023-05-31 | Yes | |
| TAAR9 | TAAR9 | A orphans | A | Mouse | Cryo-EM | 8IW9 | - | 3.1 | R | Active | 100 | 89 | Gs | αs | Mini-Gs | 59 | - | scFv16 Nanobody-35 |
Cadaverine
|
small-molecule | Agonist | - | - | No | No | Guo L, Cheng J, Lian S, Liu Q, Lu Y, Zheng Y, Zhu K, Zhang M, Kong Y, Zhang C, Rong N, Zhuang Y, Fang G, Jiang J, Zhang T, Han X, Liu Z, Xia M, Liu S, Zhang L, Liberles SD, Yu X, Xu Y, Yang F, Li Q, Sun JP | 10.1038/S41586-023-06106-4 | 2023-05-31 | Yes | |
| TAAR9 | TAAR9 | A orphans | A | Mouse | Cryo-EM | 8ITF | - | 3.5 | R | Active | 100 | 86 | Gs | αs | - | 59 | - | scFv16 Nanobody-35 |
N,N-Dimethylcyclohexylamine
|
small-molecule | Agonist | - | - | No | No | Guo L, Cheng J, Lian S, Liu Q, Lu Y, Zheng Y, Zhu K, Zhang M, Kong Y, Zhang C, Rong N, Zhuang Y, Fang G, Jiang J, Zhang T, Han X, Liu Z, Xia M, Liu S, Zhang L, Liberles SD, Yu X, Xu Y, Yang F, Li Q, Sun JP | 10.1038/S41586-023-06106-4 | 2023-05-31 | Yes | |
| TAAR9 | TAAR9 | A orphans | A | Mouse | Cryo-EM | 8IWE | - | 3.4 | R | Active | 96 | 85 | - | - | - | - | - | - |
SPERMIDINE
|
small-molecule | Agonist | - | - | No | No | Guo L, Cheng J, Lian S, Liu Q, Lu Y, Zheng Y, Zhu K, Zhang M, Kong Y, Zhang C, Rong N, Zhuang Y, Fang G, Jiang J, Zhang T, Han X, Liu Z, Xia M, Liu S, Zhang L, Liberles SD, Yu X, Xu Y, Yang F, Li Q, Sun JP | 10.1038/S41586-023-06106-4 | 2023-05-31 | Yes | |
| C3AR | C3a | Complement peptide | A | Human | Cryo-EM | 8IA8 | - | 2.9 | A | Active | 100 | 59 | Gi/o | αi1 | - | 61 | - | scFv16 |
ALA-SER-LYS-LEU-GLY-LEU-ALA-ARG
|
peptide | Agonist | C5a, C3a | peptide | No | No | - | - | 2023-05-24 | Yes | |
| CNR1 | CB1 | Cannabinoid | A | Human | Cryo-EM | 8GHV | 8GHV_refined | 2.8 | D | Active | 100 | 59 | Gi/o | αi1 | - | 62 | - | scFv16 |
CHEMBL4208628
|
small-molecule | Agonist | 2-arachidonoylglycerol, anandamide | small-molecule | No | No | Krishna Kumar K, Robertson MJ, Thadhani E, Wang H, Suomivuori CM, Powers AS, Ji L, Nikas SP, Dror RO, Inoue A, Makriyannis A, Skiniotis G, Kobilka B | 10.1038/S41467-023-37864-4 | 2023-05-24 | Yes | |
| FFAR1 | FFA1 | Free fatty acid | A | Human | Cryo-EM | 8EJC | - | 3.0 | R | Active | 100 | 90 | Gq/11 | αq | - | 60 | - | scFv16 |
fasiglifam
|
small-molecule | Agonist | myristic acid, oleic acid, docosahexaenoic acid, α-linolenic acid | small-molecule | No | No | Kumari P, Inoue A, Chapman K, Lian P, Rosenbaum DM | 10.1073/PNAS.2219569120 | 2023-05-24 | Yes | |
| FFAR1 | FFA1 | Free fatty acid | A | Human | Cryo-EM | 8EJK | - | 3.4 | R | Active | 100 | 89 | Gq/11 | αq | - | 60 | - | scFv16 |
fasiglifam
|
small-molecule | Agonist | myristic acid, oleic acid, docosahexaenoic acid, α-linolenic acid | small-molecule | No | No | Kumari P, Inoue A, Chapman K, Lian P, Rosenbaum DM | 10.1073/PNAS.2219569120 | 2023-05-24 | Yes | |
| FFAR1 | FFA1 | Free fatty acid | A | Human | Cryo-EM | 8EIT | - | 2.8 | R | Active | 100 | 89 | Gq/11 | αq | - | 59 | - | scFv16 |
docosahexaenoic acid
|
small-molecule | Agonist | myristic acid, oleic acid, docosahexaenoic acid, α-linolenic acid | small-molecule | No | No | Kumari P, Inoue A, Chapman K, Lian P, Rosenbaum DM | 10.1073/PNAS.2219569120 | 2023-05-24 | Yes | |
| OPRK | κ | Opioid | A | Human | Cryo-EM | 7Y1F | 7Y1F_refined | 3.3 | R | Active | 100 | 75 | Gi/o | αi1 | - | 61 | - | scFv16 |
dynorphin A-(1-8)
|
peptide | Agonist | dynorphin B, dynorphin A-(1-13), dynorphin A-(1-8), β-endorphin, β-neoendorphin, α-neoendorphin, [Met]enkephalin, dynorphin A, [Leu]enkephalin, big dynorphin | peptide | No | No | Chen Y, Chen B, Wu T, Zhou F, Xu F | 10.1093/PROCEL/PWAC033 | 2023-05-24 | Yes | |
| ACM4 | M4 | Acetylcholine (muscarinic) | A | Human | Cryo-EM | 7TRK | - | 2.8 | R | Active | 100 | 57 | Gi/o | αi1 | - | 64 | - | scFv16 |
iperoxo
|
small-molecule | Agonist | acetylcholine | small-molecule | No | No | - | - | 2023-05-17 | Yes | |
| ACM4 | M4 | Acetylcholine (muscarinic) | A | Human | Cryo-EM | 7TRQ | - | 2.5 | R | Active | 100 | 57 | Gi/o | αi1 | - | 64 | - | scFv16 |
iperoxo
VU0467154 |
small-molecule small-molecule |
Agonist PAM |
acetylcholine | small-molecule | No | No | - | - | 2023-05-17 | Yes | |
| ACM4 | M4 | Acetylcholine (muscarinic) | A | Human | Cryo-EM | 7TRP | - | 2.4 | R | Active | 100 | 56 | Gi/o | αi1 | - | 64 | - | scFv16 |
iperoxo
LY2033298 |
small-molecule small-molecule |
Agonist PAM |
acetylcholine | small-molecule | No | No | - | - | 2023-05-17 | Yes | |
| ACM4 | M4 | Acetylcholine (muscarinic) | A | Human | Cryo-EM | 7TRS | - | 2.8 | R | Active | 100 | 56 | Gi/o | αi1 | - | 63 | - | scFv16 |
acetylcholine
|
small-molecule | Agonist | acetylcholine | small-molecule | No | No | - | - | 2023-05-17 | Yes | |
| AGRF1 | ADGRF1 | ADGRF | B2 | Human | Cryo-EM | 8G2Y | - | 3.4 | R | Active | 100 | 28 | Gq/11 | αq | Gs-mini-Gq chimera | 52 | - | Nanobody-35 |
[1-Myristoyl-glycerol-3-YL]phosphonylcholine
|
small-molecule | Agonist | - | - | No | No | Jones DTD, Dates AN, Rawson SD, Burruss MM, Lipper CH, Blacklow SC | 10.1038/S41467-023-38083-7 | 2023-05-10 | Yes | |
| C3AR | C3a | Complement peptide | A | Human | Cryo-EM | 8HK2 | - | 2.9 | A | Active | 100 | 59 | Gi/o | αi1 | - | 64 | - | scFv16 |
C3a anaphylatoxin
|
peptide | Agonist | C5a, C3a | peptide | No | No | Wang Y, Liu W, Xu Y, He X, Yuan Q, Luo P, Fan W, Zhu J, Zhang X, Cheng X, Jiang Y, Xu HE, Zhuang Y | 10.1038/S41589-023-01339-W | 2023-05-10 | Yes | |
| C3AR | C3a | Complement peptide | A | Human | Cryo-EM | 8HK3 | 8HK3_refined | 3.2 | C | Active | 100 | 59 | Gi/o | αi1 | - | 63 | - | scFv16 |
Apo (no ligand)
|
none | Apo (no ligand) | C5a, C3a | peptide | No | No | Wang Y, Liu W, Xu Y, He X, Yuan Q, Luo P, Fan W, Zhu J, Zhang X, Cheng X, Jiang Y, Xu HE, Zhuang Y | 10.1038/S41589-023-01339-W | 2023-05-10 | Yes | |
| C5AR1 | C5a1 | Complement peptide | A | Human | Cryo-EM | 8HK5 | 8HK5_refined | 3.0 | A | Active | 100 | 84 | Gi/o | αi1 | - | 63 | - | - |
C5a
|
peptide | Agonist | C5a, ribosomal protein S19, C5a des-Arg, C3a | peptide | No | No | Wang Y, Liu W, Xu Y, He X, Yuan Q, Luo P, Fan W, Zhu J, Zhang X, Cheng X, Jiang Y, Xu HE, Zhuang Y | 10.1038/S41589-023-01339-W | 2023-05-10 | Yes | |
| CNR2 | CB2 | Cannabinoid | A | Human | Cryo-EM | 8GUS | - | 3.0 | R | Active | 100 | 81 | Gi/o | αi1 | - | 62 | - | scFv16 |
CHEMBL2179724
|
small-molecule | Agonist | 2-arachidonoylglycerol, anandamide | small-molecule | No | No | Li X, Chang H, Bouma J, de Paus LV, Mukhopadhyay P, Paloczi J, Mustafa M, van der Horst C, Kumar SS, Wu L, Yu Y, van den Berg RJBHN, Janssen APA, Lichtman A, Liu ZJ, Pacher P, van der Stelt M, Heitman LH, Hua T | 10.1038/S41467-023-37112-9 | 2023-05-10 | Yes | |
| CNR2 | CB2 | Cannabinoid | A | Human | Cryo-EM | 8GUR | 8GUR_refined | 2.8 | R | Active | 100 | 78 | Gi/o | αi1 | - | 64 | - | scFv16 |
CP55940
|
small-molecule | Agonist | 2-arachidonoylglycerol, anandamide | small-molecule | No | No | Li X, Chang H, Bouma J, de Paus LV, Mukhopadhyay P, Paloczi J, Mustafa M, van der Horst C, Kumar SS, Wu L, Yu Y, van den Berg RJBHN, Janssen APA, Lichtman A, Liu ZJ, Pacher P, van der Stelt M, Heitman LH, Hua T | 10.1038/S41467-023-37112-9 | 2023-05-10 | Yes | |
| CNR2 | CB2 | Cannabinoid | A | Human | Cryo-EM | 8GUQ | 8GUQ_refined | 3.1 | R | Active | 100 | 81 | Gi/o | αi1 | - | 62 | - | scFv16 |
olorinab
|
small-molecule | Agonist | 2-arachidonoylglycerol, anandamide | small-molecule | No | No | Li X, Chang H, Bouma J, de Paus LV, Mukhopadhyay P, Paloczi J, Mustafa M, van der Horst C, Kumar SS, Wu L, Yu Y, van den Berg RJBHN, Janssen APA, Lichtman A, Liu ZJ, Pacher P, van der Stelt M, Heitman LH, Hua T | 10.1038/S41467-023-37112-9 | 2023-05-10 | Yes | |
| CNR2 | CB2 | Cannabinoid | A | Human | Cryo-EM | 8GUT | 8GUT_refined | 3.0 | R | Active | 100 | 81 | Gi/o | αi1 | - | 62 | - | scFv16 |
1-[[4-[5-Fluoro-6-[(oxan-4-ylamino)methyl]pyridin-2-yl]phenyl]methyl]-3-(2-methylpropyl)imidazolidine-2,4-dione
|
small-molecule | Agonist | 2-arachidonoylglycerol, anandamide | small-molecule | No | No | Li X, Chang H, Bouma J, de Paus LV, Mukhopadhyay P, Paloczi J, Mustafa M, van der Horst C, Kumar SS, Wu L, Yu Y, van den Berg RJBHN, Janssen APA, Lichtman A, Liu ZJ, Pacher P, van der Stelt M, Heitman LH, Hua T | 10.1038/S41467-023-37112-9 | 2023-05-10 | Yes | |
| AA2BR | A2B | Adenosine | A | Human | Cryo-EM | 7XY7 | - | 3.3 | R | Active | 100 | 85 | Gs | αs | Mini-Gs | 57 | BRIL | - |
NECA
|
small-molecule | Agonist | adenosine | small-molecule | No | No | Chen Y, Zhang J, Weng Y, Xu Y, Lu W, Liu W, Liu M, Hua T, Song G | 10.1126/SCIADV.ADD3709 | 2023-05-03 | Yes | |
| AA2BR | A2B | Adenosine | A | Human | Cryo-EM | 7XY6 | - | 3.0 | R | Active | 100 | 86 | Gs | αs | - | 57 | BRIL | - |
BAY 60-6583
|
small-molecule | Agonist | adenosine | small-molecule | No | No | Chen Y, Zhang J, Weng Y, Xu Y, Lu W, Liu W, Liu M, Hua T, Song G | 10.1126/SCIADV.ADD3709 | 2023-05-03 | Yes | |
| GALR1 | GAL1 | Galanin | A | Human | Cryo-EM | 7XJJ | 7XJJ_refined | 3.3 | E | Active | 100 | 77 | Gi/o | αo | - | 61 | - | scFv16 |
galanin
|
peptide | Agonist | galanin, galanin-like peptide | peptide | No | No | - | - | 2023-05-03 | Yes | |
| OPRK | κ | Opioid | A | Human | Cryo-EM | 8DZR | - | 2.6 | A | Active | 100 | 68 | Gi/o | αgust | - | 58 | - | scFv16 |
CHEMBL277863
|
small-molecule | Agonist | dynorphin B, dynorphin A-(1-13), dynorphin A-(1-8), β-endorphin, β-neoendorphin, α-neoendorphin, [Met]enkephalin, dynorphin A, [Leu]enkephalin, big dynorphin | peptide | No | No | Han J, Zhang J, Nazarova AL, Bernhard SM, Krumm BE, Zhao L, Lam JH, Rangari VA, Majumdar S, Nichols DE, Katritch V, Yuan P, Fay JF, Che T | 10.1038/S41586-023-06030-7 | 2023-05-03 | Yes | |
| OPRK | κ | Opioid | A | Human | Cryo-EM | 8DZQ | 8DZQ_refined | 2.8 | A | Active | 100 | 72 | Gi/o | αo | - | 61 | - | scFv16 |
SALVINORIN B METHOXYMETHYL ETHER
|
small-molecule | Agonist | dynorphin B, dynorphin A-(1-13), dynorphin A-(1-8), β-endorphin, β-neoendorphin, α-neoendorphin, [Met]enkephalin, dynorphin A, [Leu]enkephalin, big dynorphin | peptide | No | No | Han J, Zhang J, Nazarova AL, Bernhard SM, Krumm BE, Zhao L, Lam JH, Rangari VA, Majumdar S, Nichols DE, Katritch V, Yuan P, Fay JF, Che T | 10.1038/S41586-023-06030-7 | 2023-05-03 | Yes | |
| OPRK | κ | Opioid | A | Human | Cryo-EM | 8DZP | - | 2.7 | A | Active | 100 | 74 | Gi/o | αi1 | - | 60 | - | scFv16 |
SALVINORIN B METHOXYMETHYL ETHER
|
small-molecule | Agonist | dynorphin B, dynorphin A-(1-13), dynorphin A-(1-8), β-endorphin, β-neoendorphin, α-neoendorphin, [Met]enkephalin, dynorphin A, [Leu]enkephalin, big dynorphin | peptide | No | No | Han J, Zhang J, Nazarova AL, Bernhard SM, Krumm BE, Zhao L, Lam JH, Rangari VA, Majumdar S, Nichols DE, Katritch V, Yuan P, Fay JF, Che T | 10.1038/S41586-023-06030-7 | 2023-05-03 | Yes | |
| OPRK | κ | Opioid | A | Human | Cryo-EM | 8DZS | - | 2.7 | A | Active | 100 | 71 | Gi/o | αz | - | 59 | - | scFv16 |
CHEMBL277863
|
small-molecule | Agonist | dynorphin B, dynorphin A-(1-13), dynorphin A-(1-8), β-endorphin, β-neoendorphin, α-neoendorphin, [Met]enkephalin, dynorphin A, [Leu]enkephalin, big dynorphin | peptide | No | No | Han J, Zhang J, Nazarova AL, Bernhard SM, Krumm BE, Zhao L, Lam JH, Rangari VA, Majumdar S, Nichols DE, Katritch V, Yuan P, Fay JF, Che T | 10.1038/S41586-023-06030-7 | 2023-05-03 | Yes | |
| ADRB2 | β2 | Adrenoceptors | A | Human | X-ray | 7XK9 | - | 3.4 | A | Active | 99 | 69 | - | - | - | - | T4-Lysozyme | Camelid Antibody Fragment |
CHEMBL6913
|
small-molecule | Agonist | Zn2+, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline | small-molecule | No | No | - | - | 2023-04-26 | Yes | |
| ADRB2 | β2 | Adrenoceptors | A | Human | X-ray | 7XKA | - | 3.1 | A | Active | 99 | 69 | - | - | - | - | T4-Lysozyme | Antibody fragment |
(5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol
|
small-molecule | Agonist | Zn2+, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline | small-molecule | No | No | - | - | 2023-04-26 | Yes | |
| PTH1R | PTH1 | Parathyroid hormone | B1 | Human | Cryo-EM | 8FLQ | - | 2.6 | R | Active | 100 | 61 | Gs | αs | - | 59 | - | Nanobody-35 |
Parathyroid hormone
|
peptide | Agonist | PTH, PTHrP, TIP39, PTHrP-(1-36) | peptide | No | No | Cary BP, Gerrard EJ, Belousoff MJ, Fletcher MM, Jiang Y, Russell IC, Piper SJ, Wootten D, Sexton PM | 10.1016/J.STR.2023.04.002 | 2023-04-26 | Yes | |
| PTH1R | PTH1 | Parathyroid hormone | B1 | Human | Cryo-EM | 8FLT | - | 3.0 | R | Active | 100 | 45 | Gs | αs | - | 59 | - | Nanobody-35 |
M-PTH(1-14)
|
peptide | Agonist | PTH, PTHrP, TIP39, PTHrP-(1-36) | peptide | No | No | Cary BP, Gerrard EJ, Belousoff MJ, Fletcher MM, Jiang Y, Russell IC, Piper SJ, Wootten D, Sexton PM | 10.1016/J.STR.2023.04.002 | 2023-04-26 | Yes | |
| PTH1R | PTH1 | Parathyroid hormone | B1 | Human | Cryo-EM | 8FLU | - | 2.8 | R | Active | 100 | 61 | Gs | αs | - | 58 | - | Nanobody-35 |
PTH
|
peptide | Agonist | PTH, PTHrP, TIP39, PTHrP-(1-36) | peptide | No | No | Cary BP, Gerrard EJ, Belousoff MJ, Fletcher MM, Jiang Y, Russell IC, Piper SJ, Wootten D, Sexton PM | 10.1016/J.STR.2023.04.002 | 2023-04-26 | Yes | |
| PTH1R | PTH1 | Parathyroid hormone | B1 | Human | Cryo-EM | 8FLR | - | 2.9 | R | Active | 100 | 61 | Gs | αs | - | 59 | - | Nanobody-35 |
PTHrP[1-36]
|
peptide | Agonist | PTH, PTHrP, TIP39, PTHrP-(1-36) | peptide | No | No | Cary BP, Gerrard EJ, Belousoff MJ, Fletcher MM, Jiang Y, Russell IC, Piper SJ, Wootten D, Sexton PM | 10.1016/J.STR.2023.04.002 | 2023-04-26 | Yes | |
| PTH1R | PTH1 | Parathyroid hormone | B1 | Human | Cryo-EM | 8FLS | - | 3.1 | R | Active | 100 | 61 | Gs | αs | - | 59 | - | Nanobody-35 |
abaloparatide
|
small-molecule | Agonist | PTH, PTHrP, TIP39, PTHrP-(1-36) | peptide | No | No | Cary BP, Gerrard EJ, Belousoff MJ, Fletcher MM, Jiang Y, Russell IC, Piper SJ, Wootten D, Sexton PM | 10.1016/J.STR.2023.04.002 | 2023-04-26 | Yes | |
| CML1 | chemerin | Chemerin receptor | A | Human | Cryo-EM | 7YKD | - | 2.8 | A | Active | 100 | 76 | Gi/o | αi1 | - | 61 | - | scFv16 |
chemerin C-terminal peptide
|
peptide | Agonist | 18R-HEPE, resolvin E1, chemerin C-terminal peptide, chemerin, EPA | peptide | No | No | Wang J, Chen G, Liao Q, Lyu W, Liu A, Zhu L, Du Y, Ye RD | 10.1073/PNAS.2214324120 | 2023-04-19 | Yes | |
| S1PR1 | S1P1 | Lysophospholipid (S1P) | A | Human | Cryo-EM | 8G94 | 8G94_refined | 3.2 | A | Active | 100 | 75 | Gi/o | αi1 | - | 62 | - | scFv16 |
Early activation antigen CD69
|
peptide | Agonist | dihydrosphingosine 1-phosphate, sphingosylphosphorylcholine, sphingosine 1-phosphate | small-molecule | No | No | Chen H, Qin Y, Chou M, Cyster JG, Li X | 10.7554/ELIFE.88204 | 2023-04-19 | Yes | |
| SSR2 | SST2 | Somatostatin | A | Human | Cryo-EM | 7YAE | 7YAE_refined | 3.4 | E | Active | 100 | 76 | Gi/o | αi1 | - | 64 | - | scFv16 |
Octreotide
|
peptide | Agonist | CST-17, SRIF-14, cortistatin-14, SRIF-28 | peptide | No | No | Zhao J, Fu H, Yu J, Hong W, Tian X, Qi J, Sun S, Zhao C, Wu C, Xu Z, Cheng L, Chai R, Yan W, Wei X, Shao Z | 10.1038/S41467-023-36673-Z | 2023-04-19 | Yes | |
| SSR2 | SST2 | Somatostatin | A | Human | Cryo-EM | 7YAC | 7YAC_refined | 3.2 | E | Active | 100 | 76 | Gi/o | αi1 | - | 64 | - | scFv16 |
PALTUSOTINE
|
small-molecule | Agonist | CST-17, SRIF-14, cortistatin-14, SRIF-28 | peptide | No | No | Zhao J, Fu H, Yu J, Hong W, Tian X, Qi J, Sun S, Zhao C, Wu C, Xu Z, Cheng L, Chai R, Yan W, Wei X, Shao Z | 10.1038/S41467-023-36673-Z | 2023-04-19 | Yes | |
| GLR | glucagon | Glucagon | B1 | Human | Cryo-EM | 8FU6 | 8FU6_refined | 2.9 | R | Active | 100 | 72 | Gs | αs | - | 54 | - | Nanobody-35 |
Glucagon derivative ZP3780
|
peptide | Agonist | glucagon | peptide | No | No | Krishna Kumar K, O'Brien ES, Habrian CH, Latorraca NR, Wang H, Tuneew I, Montabana E, Marqusee S, Hilger D, Isacoff EY, Mathiesen JM, Kobilka BK | 10.1016/J.CELL.2023.02.028 | 2023-04-12 | Yes | |
| HCAR2 | HCA2 | Hydroxycarboxylic acid | A | Human | X-ray | 7ZLY | - | 2.7 | A | Active | 56 | 83 | - | - | - | - | BRIL | - |
Apo (no ligand)
|
none | Apo (no ligand) | butyric acid, β-D-hydroxybutyric acid | small-molecule | No | No | Yang Y, Kang HJ, Gao R, Wang J, Han GW, DiBerto JF, Wu L, Tong J, Qu L, Wu Y, Pileski R, Li X, Zhang XC, Zhao S, Kenakin T, Wang Q, Stevens RC, Peng W, Roth BL, Rao Z, Liu ZJ | 10.1038/S41467-023-37177-6 | 2023-04-12 | Yes | |
| HCAR2 | HCA2 | Hydroxycarboxylic acid | A | Human | X-ray | 7ZL9 | - | 2.7 | A | Active | 56 | 83 | - | - | - | - | BRIL | - |
Apo (no ligand)
|
none | Apo (no ligand) | butyric acid, β-D-hydroxybutyric acid | small-molecule | No | No | Yang Y, Kang HJ, Gao R, Wang J, Han GW, DiBerto JF, Wu L, Tong J, Qu L, Wu Y, Pileski R, Li X, Zhang XC, Zhao S, Kenakin T, Wang Q, Stevens RC, Peng W, Roth BL, Rao Z, Liu ZJ | 10.1038/S41467-023-37177-6 | 2023-04-12 | Yes | |
| MTLR | motilin | Motilin | A | Human | Cryo-EM | 8IBU | 8IBU_refined | 3.5 | R | Active | 100 | 66 | Gq/11 | αq | - | 60 | BRIL | scFv16 |
erythromycin
|
small-molecule | Agonist | motilin | peptide | No | No | You C, Zhang Y, Xu Y, Xu P, Li Z, Li H, Huang S, Chen Z, Li J, Xu HE, Jiang Y | 10.1126/SCIADV.ADE9020 | 2023-04-12 | Yes | |
| MTLR | motilin | Motilin | A | Human | Cryo-EM | 8IBV | 8IBV_refined | 3.2 | R | Active | 100 | 68 | Gq/11 | αq | - | 60 | BRIL | scFv16 |
motilin
|
peptide | Agonist | motilin | peptide | No | No | You C, Zhang Y, Xu Y, Xu P, Li Z, Li H, Huang S, Chen Z, Li J, Xu HE, Jiang Y | 10.1126/SCIADV.ADE9020 | 2023-04-12 | Yes | |
| OPRK | κ | Opioid | A | Human | X-ray | 7YIT | - | 3.3 | A | Active | 100 | 74 | - | - | - | - | BRIL | Nanobody-39 |
nalfurafine
|
small-molecule | Agonist | dynorphin B, dynorphin A-(1-13), dynorphin A-(1-8), β-endorphin, β-neoendorphin, α-neoendorphin, [Met]enkephalin, dynorphin A, [Leu]enkephalin, big dynorphin | peptide | No | No | El Daibani A, Paggi JM, Kim K, Laloudakis YD, Popov P, Bernhard SM, Krumm BE, Olsen RHJ, Diberto J, Carroll FI, Katritch V, Wunsch B, Dror RO, Che T | 10.1038/S41467-023-37041-7 | 2023-04-12 | Yes | |
| 5HT6R | 5-HT6 | 5-Hydroxytryptamine | A | Human | Cryo-EM | 7YS6 | 7YS6_refined | 3.0 | A | Active | 100 | 61 | Gs | αs | - | 59 | - | scFv16 |
5-hydroxytryptamine
|
small-molecule | Agonist | 5-hydroxytryptamine | small-molecule | No | No | - | - | 2023-03-29 | Yes | |
| AGTR1 | AT1 | Angiotensin | A | Human | Cryo-EM | 7F6G | 7F6G_refined | 2.9 | A | Active | 100 | 86 | Gq/11 | αq | - | 97 | - | - |
SAR1-AngII
|
peptide | Agonist | angiotensin III, angiotensin IV, angiotensin A, angiotensin II | peptide | No | No | - | - | 2023-03-29 | Yes | |
| FSHR | FSH | Glycoprotein hormone | A | Human | Cryo-EM | 8I2G | - | 2.8 | R | Active | 100 | 86 | Gs | αs | fused Gs | 58 | - | Nanobody-35 |
Follitropin subunit beta
Glycoprotein alpha FSHR agonist 1 |
peptide peptide small-molecule |
Agonist | FSH | peptide | No | No | Duan J, Xu P, Zhang H, Luan X, Yang J, He X, Mao C, Shen DD, Ji Y, Cheng X, Jiang H, Jiang Y, Zhang S, Zhang Y, Xu HE | 10.1038/S41467-023-36170-3 | 2023-03-29 | Yes | |
| NTR1 | NTS1 | Neurotensin | A | Rat | Cryo-EM | 8FMZ | - | 2.6 | A | Active | 100 | 66 | Gq/11 | αq | Mini-Gq | 57 | - | scFv16 |
neurotensin
|
peptide | Agonist | neurotensin, neuromedin N | peptide | No | No | Krumm BE, DiBerto JF, Olsen RHJ, Kang HJ, Slocum ST, Zhang S, Strachan RT, Huang XP, Slosky LM, Pinkerton AB, Barak LS, Caron MG, Kenakin T, Fay JF, Roth BL | 10.1021/ACS.BIOCHEM.3C00029 | 2023-03-29 | Yes | |
| NTR1 | NTS1 | Neurotensin | A | Rat | Cryo-EM | 8FN0 | - | 2.9 | A | Active | 100 | 67 | Gi/o | αo | Mini-Go | 60 | - | scFv16 |
neurotensin
CHEMBL4576388 |
peptide small-molecule |
Agonist PAM |
neurotensin, neuromedin N | peptide | No | No | Krumm BE, DiBerto JF, Olsen RHJ, Kang HJ, Slocum ST, Zhang S, Strachan RT, Huang XP, Slosky LM, Pinkerton AB, Barak LS, Caron MG, Kenakin T, Fay JF, Roth BL | 10.1021/ACS.BIOCHEM.3C00029 | 2023-03-29 | Yes | |
| NTR1 | NTS1 | Neurotensin | A | Rat | Cryo-EM | 8FN1 | - | 2.9 | A | Active | 100 | 66 | Gi/o | αo | - | 60 | - | scFv16 |
neurotensin
|
peptide | Agonist | neurotensin, neuromedin N | peptide | No | No | Krumm BE, DiBerto JF, Olsen RHJ, Kang HJ, Slocum ST, Zhang S, Strachan RT, Huang XP, Slosky LM, Pinkerton AB, Barak LS, Caron MG, Kenakin T, Fay JF, Roth BL | 10.1021/ACS.BIOCHEM.3C00029 | 2023-03-29 | Yes | |
| OPSD | Rhodopsin | Opsins | A | Bovine | X-ray | 8A6E | 8A6E_refined | 1.8 | A | Inactive | 24 | 87 | - | - | - | - | - | - |
Retinal (11-cis)
|
small-molecule | Agonist | - | - | No | No | Gruhl T, Weinert T, Rodrigues MJ, Milne CJ, Ortolani G, Nass K, Nango E, Sen S, Johnson PJM, Cirelli C, Furrer A, Mous S, Skopintsev P, James D, Dworkowski F, Bath P, Kekilli D, Ozerov D, Tanaka R, Glover H, Bacellar C, Brunle S, Casadei CM, Diethelm AD, Gashi D, Gotthard G, Guixa-Gonzalez R, Joti Y, Kabanova V, Knopp G, Lesca E, Ma P, Martiel I, Muhle J, Owada S, Pamula F, Sarabi D, Tejero O, Tsai CJ, Varma N, Wach A, Boutet S, Tono K, Nogly P, Deupi X, Iwata S, Neutze R, Standfuss J, Schertler G, Panneels V | 10.1038/S41586-023-05863-6 | 2023-03-29 | Yes | |
| OPSD | Rhodopsin | Opsins | A | Bovine | X-ray | 7ZBE | 7ZBE_refined | 1.8 | A | Inactive | 24 | 87 | - | - | - | - | - | - |
Retinal (11-cis)
|
small-molecule | Inverse agonist | - | - | No | No | Gruhl T, Weinert T, Rodrigues MJ, Milne CJ, Ortolani G, Nass K, Nango E, Sen S, Johnson PJM, Cirelli C, Furrer A, Mous S, Skopintsev P, James D, Dworkowski F, Bath P, Kekilli D, Ozerov D, Tanaka R, Glover H, Bacellar C, Brunle S, Casadei CM, Diethelm AD, Gashi D, Gotthard G, Guixa-Gonzalez R, Joti Y, Kabanova V, Knopp G, Lesca E, Ma P, Martiel I, Muhle J, Owada S, Pamula F, Sarabi D, Tejero O, Tsai CJ, Varma N, Wach A, Boutet S, Tono K, Nogly P, Deupi X, Iwata S, Neutze R, Standfuss J, Schertler G, Panneels V | 10.1038/S41586-023-05863-6 | 2023-03-29 | Yes | |
| OPSD | Rhodopsin | Opsins | A | Bovine | X-ray | 8A6C | 8A6C_refined | 1.8 | A | Inactive | 24 | 87 | - | - | - | - | - | - |
Retinal (11-cis)
|
small-molecule | Agonist | - | - | No | No | Gruhl T, Weinert T, Rodrigues MJ, Milne CJ, Ortolani G, Nass K, Nango E, Sen S, Johnson PJM, Cirelli C, Furrer A, Mous S, Skopintsev P, James D, Dworkowski F, Bath P, Kekilli D, Ozerov D, Tanaka R, Glover H, Bacellar C, Brunle S, Casadei CM, Diethelm AD, Gashi D, Gotthard G, Guixa-Gonzalez R, Joti Y, Kabanova V, Knopp G, Lesca E, Ma P, Martiel I, Muhle J, Owada S, Pamula F, Sarabi D, Tejero O, Tsai CJ, Varma N, Wach A, Boutet S, Tono K, Nogly P, Deupi X, Iwata S, Neutze R, Standfuss J, Schertler G, Panneels V | 10.1038/S41586-023-05863-6 | 2023-03-29 | Yes | |
| OPSD | Rhodopsin | Opsins | A | Bovine | X-ray | 7ZBC | - | 1.8 | A | Inactive | 24 | 87 | - | - | - | - | - | - |
Retinal (11-cis)
|
small-molecule | Inverse agonist | - | - | No | No | Gruhl T, Weinert T, Rodrigues MJ, Milne CJ, Ortolani G, Nass K, Nango E, Sen S, Johnson PJM, Cirelli C, Furrer A, Mous S, Skopintsev P, James D, Dworkowski F, Bath P, Kekilli D, Ozerov D, Tanaka R, Glover H, Bacellar C, Brunle S, Casadei CM, Diethelm AD, Gashi D, Gotthard G, Guixa-Gonzalez R, Joti Y, Kabanova V, Knopp G, Lesca E, Ma P, Martiel I, Muhle J, Owada S, Pamula F, Sarabi D, Tejero O, Tsai CJ, Varma N, Wach A, Boutet S, Tono K, Nogly P, Deupi X, Iwata S, Neutze R, Standfuss J, Schertler G, Panneels V | 10.1038/S41586-023-05863-6 | 2023-03-29 | Yes | |
| OPSD | Rhodopsin | Opsins | A | Bovine | X-ray | 8A6D | 8A6D_refined | 1.8 | A | Inactive | 24 | 87 | - | - | - | - | - | - |
Retinal (11-cis)
|
small-molecule | Agonist | - | - | No | No | Gruhl T, Weinert T, Rodrigues MJ, Milne CJ, Ortolani G, Nass K, Nango E, Sen S, Johnson PJM, Cirelli C, Furrer A, Mous S, Skopintsev P, James D, Dworkowski F, Bath P, Kekilli D, Ozerov D, Tanaka R, Glover H, Bacellar C, Brunle S, Casadei CM, Diethelm AD, Gashi D, Gotthard G, Guixa-Gonzalez R, Joti Y, Kabanova V, Knopp G, Lesca E, Ma P, Martiel I, Muhle J, Owada S, Pamula F, Sarabi D, Tejero O, Tsai CJ, Varma N, Wach A, Boutet S, Tono K, Nogly P, Deupi X, Iwata S, Neutze R, Standfuss J, Schertler G, Panneels V | 10.1038/S41586-023-05863-6 | 2023-03-29 | Yes | |
| AA2AR | A2A | Adenosine | A | Human | X-ray | 8GNG | 8GNG_refined | 3.2 | X | Inactive | 1 | 69 | - | - | - | - | - | Antibody fab fragment light chain Antibody fab fragment heavy chain |
istradefylline
|
small-molecule | Antagonist | adenosine | small-molecule | No | No | Ohno Y, Suzuki M, Asada H, Kanda T, Saki M, Miyagi H, Yasunaga M, Suno C, Iwata S, Saito JI, Uchida S | 10.1124/MOLPHARM.122.000633 | 2023-03-22 | Yes | |
| AA2AR | A2A | Adenosine | A | Human | X-ray | 8GNE | - | 2.3 | A | Inactive | 1 | 72 | - | - | - | - | BRIL | - |
Sipagladenant
|
small-molecule | Inverse agonist | adenosine | small-molecule | No | No | Ohno Y, Suzuki M, Asada H, Kanda T, Saki M, Miyagi H, Yasunaga M, Suno C, Iwata S, Saito JI, Uchida S | 10.1124/MOLPHARM.122.000633 | 2023-03-22 | Yes | |
| EDNRA | ETA | Endothelin | A | Human | Cryo-EM | 8HCQ | 8HCQ_refined | 3.0 | R | Active | 100 | 71 | Gq/11 | αq | - | 57 | - | scFv16 |
ENDOTHELIN
|
protein | Agonist | endothelin-2, endothelin-3, endothelin-1 | peptide | No | No | - | - | 2023-03-22 | Yes | |
| EDNRB | ETB | Endothelin | A | Human | Cryo-EM | 8HBD | 8HBD_refined | 3.0 | R | Active | 100 | 68 | Gi/o | αi1 | - | 61 | - | scFv16 |
sovateltide
|
peptide | Agonist | endothelin-2, endothelin-3, endothelin-1 | peptide | No | No | - | - | 2023-03-22 | Yes | |
| EDNRB | ETB | Endothelin | A | Human | Cryo-EM | 8HCX | 8HCX_refined | 3.5 | C | Active | 100 | 66 | Gq/11 | αq | - | 61 | - | scFv16 |
ENDOTHELIN
|
protein | Agonist | endothelin-2, endothelin-3, endothelin-1 | peptide | No | No | - | - | 2023-03-22 | Yes | |
| FSHR | FSH | Glycoprotein hormone | A | Human | Cryo-EM | 8I2H | 8I2H_refined | 6.0 | A | Inactive | 16 | 82 | - | - | - | - | - | - |
Apo (no ligand)
|
none | Apo (no ligand) | FSH | peptide | No | No | Duan J, Xu P, Zhang H, Luan X, Yang J, He X, Mao C, Shen DD, Ji Y, Cheng X, Jiang H, Jiang Y, Zhang S, Zhang Y, Xu HE | 10.1038/S41467-023-36170-3 | 2023-03-22 | Yes | |
| NPY2R | Y2 | Neuropeptide Y | A | Human | Cryo-EM | 7YON | 7YON_refined | 3.0 | R | Active | 100 | 79 | Gi/o | αi1 | - | 62 | - | scFv16 |
Peptide YY
|
peptide | Agonist | PYY-(3-36), peptide YY, neuropeptide Y-(3-36), pancreatic polypeptide, neuropeptide Y | peptide | No | No | Kang H, Park C, Choi YK, Bae J, Kwon S, Kim J, Choi C, Seok C, Im W, Choi HJ | 10.1016/J.STR.2022.11.010 | 2023-03-22 | Yes | |
| NPY2R | Y2 | Neuropeptide Y | A | Human | Cryo-EM | 7YOO | 7YOO_refined | 3.1 | R | Active | 96 | 79 | - | - | - | - | - | - |
neuropeptide Y
|
peptide | Agonist | PYY-(3-36), peptide YY, neuropeptide Y-(3-36), pancreatic polypeptide, neuropeptide Y | peptide | No | No | Kang H, Park C, Choi YK, Bae J, Kwon S, Kim J, Choi C, Seok C, Im W, Choi HJ | 10.1016/J.STR.2022.11.010 | 2023-03-22 | Yes | |
| O51E2 | OR51E2 | Odorant family 51 | O1 | Human | Cryo-EM | 8F76 | 8F76_refined | 3.1 | A | Active | - | 94 | Gs | αs | Mini-Gs | 55 | - | Nanobody-35 |
propanoic acid
|
small-molecule | Agonist | - | - | No | No | Billesbolle CB, de March CA, van der Velden WJC, Ma N, Tewari J, Del Torrent CL, Li L, Faust B, Vaidehi N, Matsunami H, Manglik A | 10.1038/S41586-023-05798-Y | 2023-03-22 | Yes | |
| FFAR4 | FFA4 | Free fatty acid | A | Human | Cryo-EM | 8ID8 | - | 3.0 | R | Active | 100 | 81 | Gi/o | αi1 | - | 64 | - | scFv16 |
TUG-891
|
small-molecule | Agonist | oleic acid, myristic acid, linoleic acid, α-linolenic acid | small-molecule | No | No | Mao C, Xiao P, Tao XN, Qin J, He QT, Zhang C, Guo SC, Du YQ, Chen LN, Shen DD, Yang ZS, Zhang HQ, Huang SM, He YH, Cheng J, Zhong YN, Shang P, Chen J, Zhang DL, Wang QL, Liu MX, Li GY, Guo Y, Xu HE, Wang C, Zhang C, Feng S, Yu X, Zhang Y, Sun JP | 10.1126/SCIENCE.ADD6220 | 2023-03-15 | Yes | |
| FFAR4 | FFA4 | Free fatty acid | A | Human | Cryo-EM | 8ID9 | 8ID9_refined | 3.0 | R | Active | 100 | 78 | Gi/o | αi1 | - | 56 | - | scFv16 |
EPA
|
small-molecule | Agonist | oleic acid, myristic acid, linoleic acid, α-linolenic acid | small-molecule | No | No | Mao C, Xiao P, Tao XN, Qin J, He QT, Zhang C, Guo SC, Du YQ, Chen LN, Shen DD, Yang ZS, Zhang HQ, Huang SM, He YH, Cheng J, Zhong YN, Shang P, Chen J, Zhang DL, Wang QL, Liu MX, Li GY, Guo Y, Xu HE, Wang C, Zhang C, Feng S, Yu X, Zhang Y, Sun JP | 10.1126/SCIENCE.ADD6220 | 2023-03-15 | Yes | |
| FFAR4 | FFA4 | Free fatty acid | A | Human | Cryo-EM | 8ID3 | 8ID3_refined | 3.1 | R | Active | 100 | 81 | Gi/o | αi1 | - | 64 | - | scFv16 |
9-Hydroxyoctadecanoic acid
|
small-molecule | Agonist | oleic acid, myristic acid, linoleic acid, α-linolenic acid | small-molecule | No | No | Mao C, Xiao P, Tao XN, Qin J, He QT, Zhang C, Guo SC, Du YQ, Chen LN, Shen DD, Yang ZS, Zhang HQ, Huang SM, He YH, Cheng J, Zhong YN, Shang P, Chen J, Zhang DL, Wang QL, Liu MX, Li GY, Guo Y, Xu HE, Wang C, Zhang C, Feng S, Yu X, Zhang Y, Sun JP | 10.1126/SCIENCE.ADD6220 | 2023-03-15 | Yes | |
| FFAR4 | FFA4 | Free fatty acid | A | Human | Cryo-EM | 8ID4 | - | 3.1 | R | Active | 100 | 79 | Gi/o | αi1 | - | 64 | - | scFv16 |
linoleic acid
|
small-molecule | Agonist | oleic acid, myristic acid, linoleic acid, α-linolenic acid | small-molecule | No | No | Mao C, Xiao P, Tao XN, Qin J, He QT, Zhang C, Guo SC, Du YQ, Chen LN, Shen DD, Yang ZS, Zhang HQ, Huang SM, He YH, Cheng J, Zhong YN, Shang P, Chen J, Zhang DL, Wang QL, Liu MX, Li GY, Guo Y, Xu HE, Wang C, Zhang C, Feng S, Yu X, Zhang Y, Sun JP | 10.1126/SCIENCE.ADD6220 | 2023-03-15 | Yes | |
| FFAR4 | FFA4 | Free fatty acid | A | Human | Cryo-EM | 8ID6 | - | 2.8 | R | Active | 100 | 80 | Gi/o | αi1 | - | 64 | - | scFv16 |
oleic acid
|
small-molecule | Agonist | oleic acid, myristic acid, linoleic acid, α-linolenic acid | small-molecule | No | No | Mao C, Xiao P, Tao XN, Qin J, He QT, Zhang C, Guo SC, Du YQ, Chen LN, Shen DD, Yang ZS, Zhang HQ, Huang SM, He YH, Cheng J, Zhong YN, Shang P, Chen J, Zhang DL, Wang QL, Liu MX, Li GY, Guo Y, Xu HE, Wang C, Zhang C, Feng S, Yu X, Zhang Y, Sun JP | 10.1126/SCIENCE.ADD6220 | 2023-03-15 | Yes | |
| GPR21 | GPR21 | A orphans | A | Human | Cryo-EM | 8HJ2 | 8HJ2_refined | 3.8 | R | Active | 100 | 81 | Gs | αs | Mini-Gs | 61 | - | Nanobody-35 |
Apo (no ligand)
|
none | Apo (no ligand) | - | - | No | No | Lin X, Chen B, Wu Y, Han Y, Qi A, Wang J, Yang Z, Wei X, Zhao T, Wu L, Xie X, Sun J, Zheng J, Zhao S, Xu F | 10.1038/S41467-023-35882-W | 2023-03-15 | Yes | |
| GPR21 | GPR21 | A orphans | A | Human | Cryo-EM | 8HIX | - | 3.1 | R | Active | 100 | 81 | Gs | αs | Mini-Gs | 61 | - | Nanobody-35 |
Apo (no ligand)
|
none | Apo (no ligand) | - | - | No | No | Lin X, Chen B, Wu Y, Han Y, Qi A, Wang J, Yang Z, Wei X, Zhao T, Wu L, Xie X, Sun J, Zheng J, Zhao S, Xu F | 10.1038/S41467-023-35882-W | 2023-03-15 | Yes | |
| GPR21 | GPR21 | A orphans | A | Human | Cryo-EM | 8HJ0 | - | 3.1 | R | Active | 100 | 81 | Gs | αs | Mini-Gs | 61 | - | Nanobody-35 |
Apo (no ligand)
|
none | Apo (no ligand) | - | - | No | No | Lin X, Chen B, Wu Y, Han Y, Qi A, Wang J, Yang Z, Wei X, Zhao T, Wu L, Xie X, Sun J, Zheng J, Zhao S, Xu F | 10.1038/S41467-023-35882-W | 2023-03-15 | Yes | |
| AA2AR | A2A | Adenosine | A | Human | MicroED | 8FYN | 8FYN_refined | 2.0 | A | Inactive | 1 | 72 | - | - | - | - | BRIL | - |
ZM-241385
|
small-molecule | Antagonist | adenosine | small-molecule | No | No | Martynowycz MW, Shiriaeva A, Clabbers MTB, Nicolas WJ, Weaver SJ, Hattne J, Gonen T | 10.1038/S41467-023-36733-4 | 2023-03-08 | Yes | |
| FFAR4 | FFA4 | Free fatty acid | A | Human | Cryo-EM | 8G59 | 8G59_refined | 2.6 | R | Active | 100 | 78 | Gq/11 | αq | - | 61 | - | - |
TUG-891
|
small-molecule | Agonist | oleic acid, myristic acid, linoleic acid, α-linolenic acid | small-molecule | No | No | Mao C, Xiao P, Tao XN, Qin J, He QT, Zhang C, Guo SC, Du YQ, Chen LN, Shen DD, Yang ZS, Zhang HQ, Huang SM, He YH, Cheng J, Zhong YN, Shang P, Chen J, Zhang DL, Wang QL, Liu MX, Li GY, Guo Y, Xu HE, Wang C, Zhang C, Feng S, Yu X, Zhang Y, Sun JP | 10.1126/SCIENCE.ADD6220 | 2023-03-08 | Yes | |
| GPR20 | GPR20 | A orphans | A | Human | Cryo-EM | 8HS3 | - | 3.1 | R | Active | 100 | 78 | Gi/o | αi1 | - | 62 | BRIL | scFv16 |
Apo (no ligand)
|
none | Apo (no ligand) | - | - | No | No | Lin X, Jiang S, Wu Y, Wei X, Han GW, Wu L, Liu J, Chen B, Zhang Z, Zhao S, Cherezov V, Xu F | 10.1038/S41421-023-00520-8 | 2023-03-08 | Yes | |
| GPR20 | GPR20 | A orphans | A | Human | Cryo-EM | 8HSC | - | 3.2 | R | Active | 100 | 76 | Gi/o | αi1 | - | 62 | BRIL | Antibody fab fragment light chain Antibody fab fragment heavy chain scFv16 |
Apo (no ligand)
|
none | Apo (no ligand) | - | - | No | No | Lin X, Jiang S, Wu Y, Wei X, Han GW, Wu L, Liu J, Chen B, Zhang Z, Zhao S, Cherezov V, Xu F | 10.1038/S41421-023-00520-8 | 2023-03-08 | Yes | |
| GPR20 | GPR20 | A orphans | A | Human | Cryo-EM | 8HS2 | 8HS2_refined | 3.1 | R | Active | 56 | 80 | - | - | - | - | BRIL | Antibody fab fragment heavy chain Antibody fab fragment light chain |
Apo (no ligand)
|
none | Apo (no ligand) | - | - | No | No | Lin X, Jiang S, Wu Y, Wei X, Han GW, Wu L, Liu J, Chen B, Zhang Z, Zhao S, Cherezov V, Xu F | 10.1038/S41421-023-00520-8 | 2023-03-08 | Yes | |
| C5AR1 | C5a1 | Complement peptide | A | Human | Cryo-EM | 7Y66 | - | 2.9 | D | Active | 100 | 80 | Gi/o | αi1 | - | 63 | - | scFv16 |
BM213
|
peptide | Agonist | C5a, ribosomal protein S19, C5a des-Arg, C3a | peptide | No | No | Feng Y, Zhao C, Deng Y, Wang H, Ma L, Liu S, Tian X, Wang B, Bin Y, Chen P, Yan W, Fu P, Shao Z | 10.1038/S41422-023-00779-2 | 2023-03-01 | Yes | |
| C5AR1 | C5a1 | Complement peptide | A | Human | Cryo-EM | 7Y67 | 7Y67_refined | 2.8 | D | Active | 100 | 79 | Gi/o | αi1 | - | 63 | - | scFv16 |
C089
|
peptide | Agonist | C5a, ribosomal protein S19, C5a des-Arg, C3a | peptide | No | No | Feng Y, Zhao C, Deng Y, Wang H, Ma L, Liu S, Tian X, Wang B, Bin Y, Chen P, Yan W, Fu P, Shao Z | 10.1038/S41422-023-00779-2 | 2023-03-01 | Yes | |
| C5AR1 | C5a1 | Complement peptide | A | Human | Cryo-EM | 7Y64 | - | 2.9 | D | Active | 100 | 84 | Gi/o | αi1 | - | 63 | - | scFv16 |
C5a anaphylatoxin
|
peptide | Agonist | C5a, ribosomal protein S19, C5a des-Arg, C3a | peptide | No | No | Feng Y, Zhao C, Deng Y, Wang H, Ma L, Liu S, Tian X, Wang B, Bin Y, Chen P, Yan W, Fu P, Shao Z | 10.1038/S41422-023-00779-2 | 2023-03-01 | Yes | |
| C5AR1 | C5a1 | Complement peptide | A | Human | Cryo-EM | 7Y65 | - | 3.2 | D | Active | 100 | 81 | Gi/o | αi1 | - | 64 | - | scFv16 |
C5a
|
peptide | Agonist | C5a, ribosomal protein S19, C5a des-Arg, C3a | peptide | No | No | Feng Y, Zhao C, Deng Y, Wang H, Ma L, Liu S, Tian X, Wang B, Bin Y, Chen P, Yan W, Fu P, Shao Z | 10.1038/S41422-023-00779-2 | 2023-03-01 | Yes | |
| GPR21 | GPR21 | A orphans | A | Human | Cryo-EM | 8HMV | 8HMV_refined | 2.9 | A | Active | 100 | 79 | Gs | αs | - | 58 | - | Nanobody-35 |
Apo (no ligand)
|
none | Apo (no ligand) | - | - | No | No | Wong TS, Gao W, Chen G, Qiu C, He G, Ye F, Wu Z, Zeng Z, Du Y | 10.1002/MCO2.205 | 2023-03-01 | Yes | |
| RL3R2 | RXFP4 | Relaxin family peptide | A | Human | Cryo-EM | 7YK7 | 7YK7_refined | 2.8 | R | Active | 100 | 75 | Gi/o | αi2 | - | 61 | - | scFv16 |
DC591053
|
small-molecule | Agonist | INSL5, relaxin-3 (B chain), relaxin-3 | peptide | No | No | Chen Y, Zhou Q, Wang J, Xu Y, Wang Y, Yan J, Wang Y, Zhu Q, Zhao F, Li C, Chen CW, Cai X, Bathgate RAD, Shen C, Eric Xu H, Yang D, Liu H, Wang MW | 10.1038/S41467-023-36182-Z | 2023-03-01 | Yes | |
| RL3R2 | RXFP4 | Relaxin family peptide | A | Human | Cryo-EM | 7YK6 | 7YK6_refined | 3.0 | R | Active | 100 | 76 | Gi/o | αi2 | - | 59 | - | scFv16 |
CHEMBL4522365
|
small-molecule | Agonist | INSL5, relaxin-3 (B chain), relaxin-3 | peptide | No | No | Chen Y, Zhou Q, Wang J, Xu Y, Wang Y, Yan J, Wang Y, Zhu Q, Zhao F, Li C, Chen CW, Cai X, Bathgate RAD, Shen C, Eric Xu H, Yang D, Liu H, Wang MW | 10.1038/S41467-023-36182-Z | 2023-03-01 | Yes | |
| RL3R2 | RXFP4 | Relaxin family peptide | A | Human | Cryo-EM | 7YJ4 | - | 3.2 | R | Active | 100 | 76 | Gi/o | αi2 | - | 58 | - | scFv16 |
Insulin-like peptide INSL5 B chain
Insulin-like peptide INSL5 A chain |
peptide peptide |
Agonist | INSL5, relaxin-3 (B chain), relaxin-3 | peptide | No | No | Chen Y, Zhou Q, Wang J, Xu Y, Wang Y, Yan J, Wang Y, Zhu Q, Zhao F, Li C, Chen CW, Cai X, Bathgate RAD, Shen C, Eric Xu H, Yang D, Liu H, Wang MW | 10.1038/S41467-023-36182-Z | 2023-03-01 | Yes | |
| GRPR | BB2 | Bombesin | A | Human | Cryo-EM | 7W3Z | - | 3.0 | A | Active | 100 | 78 | Gq/11 | αq | - | 98 | - | scFv16 |
Gastrin-releasing peptide
|
peptide | Agonist | gastrin-releasing peptide, neuromedin B, neuromedin C, gastrin releasing peptide(14-27) (human), GRP-(18-27) | peptide | No | No | - | - | 2023-02-22 | Yes | |
| GRPR | BB2 | Bombesin | A | Human | X-ray | 7W41 | 7W41_refined | 3.0 | A | Inactive | 8 | 75 | - | - | - | - | GlgA glycogen synthase | - |
PD 176252
|
small-molecule | Antagonist | gastrin-releasing peptide, neuromedin B, neuromedin C, gastrin releasing peptide(14-27) (human), GRP-(18-27) | peptide | No | No | Peng S, Zhan Y, Zhang D, Ren L, Chen A, Chen ZF, Zhang H | 10.1073/PNAS.2216230120 | 2023-02-22 | Yes | |
| GRPR | BB2 | Bombesin | A | Human | Cryo-EM | 7W40 | 7W40_refined | 3.0 | A | Active | 100 | 78 | Gq/11 | αq | - | 79 | - | scFv16 |
Bombesin
|
peptide | Agonist | gastrin-releasing peptide, neuromedin B, neuromedin C, gastrin releasing peptide(14-27) (human), GRP-(18-27) | peptide | No | No | Peng S, Zhan Y, Zhang D, Ren L, Chen A, Chen ZF, Zhang H | 10.1073/PNAS.2216230120 | 2023-02-22 | Yes | |
| HCAR2 | HCA2 | Hydroxycarboxylic acid | A | Human | Cryo-EM | 7XK2 | 7XK2_refined | 3.1 | R | Active | 100 | 78 | Gi/o | αi1 | - | 63 | - | scFv16 |
MK 6892
|
small-molecule | Agonist | butyric acid, β-D-hydroxybutyric acid | small-molecule | No | No | Yang Y, Kang HJ, Gao R, Wang J, Han GW, DiBerto JF, Wu L, Tong J, Qu L, Wu Y, Pileski R, Li X, Zhang XC, Zhao S, Kenakin T, Wang Q, Stevens RC, Peng W, Roth BL, Rao Z, Liu ZJ | 10.1038/S41467-023-37177-6 | 2023-02-22 | Yes | |
| NMUR2 | NMU2 | Neuromedin U | A | Human | Cryo-EM | 7XK8 | 7XK8_refined | 3.3 | R | Active | 100 | 68 | Gi/o | αi1 | - | 64 | - | - |
Neuromedin U-25 (human)
|
peptide | Agonist | neuromedin U-23, neuromedin S-33, neuromedin U-25, neuromedin S-36 | peptide | No | No | Zhao W, Zhang W, Wang M, Lu M, Chen S, Tang T, Schnapp G, Wagner H, Brennauer A, Yi C, Chu X, Han S, Wu B, Zhao Q | 10.1038/S41467-022-34814-4 | 2023-02-22 | Yes | |
| GP174 | GPR174 | A orphans | A | Human | Cryo-EM | 7XV3 | 7XV3_refined | 2.8 | R | Active | 100 | 87 | Gs | αs | - | 59 | - | - |
(2~{S})-2-$l^{4}-azanyl-3-[[(2~{R})-3-octadecanoyloxy-2-oxidanyl-propoxy]-oxidanyl-oxidanylidene-$l^{6}-phosphanyl]oxy-propanoic acid
|
small-molecule | Agonist | lysophosphatidylserine | small-molecule | No | No | Liang J, Inoue A, Ikuta T, Xia R, Wang N, Kawakami K, Xu Z, Qian Y, Zhu X, Zhang A, Guo C, Huang Z, He Y | 10.1038/S41467-023-36575-0 | 2023-02-15 | Yes | |
| RXFP1 | RXFP1 | Relaxin family peptide | A | Human | Cryo-EM | 7TMW | - | 3.2 | R | Active | 100 | 36 | Gs | αs | Gs fused to receptor | 57 | - | Nanobody-35 |
H2 relaxin
|
small-molecule | Agonist | relaxin, relaxin-3, relaxin-1 | peptide | No | No | - | - | 2023-02-15 | Yes | |
| GPR35 | GPR35 | A orphans | A | Human | Cryo-EM | 8H8J | 8H8J_refined | 3.2 | C | Active | 100 | 92 | G12/13 | α13 | - | 60 | - | scFv16 |
lodoxamide
|
small-molecule | Agonist | 2-oleoyl-LPA, kynurenic acid, 1-Lyso-2-oleoyl-phosphatidic acid, 2-Oleoyllysophosphatydic acid | small-molecule | No | No | Duan J, Liu Q, Yuan Q, Ji Y, Zhu S, Tan Y, He X, Xu Y, Shi J, Cheng X, Jiang H, Eric Xu H, Jiang Y | 10.1038/S41421-022-00499-8 | 2023-02-08 | Yes | |
| ACM2 | M2 | Acetylcholine (muscarinic) | A | Human | Cryo-EM | 7T90 | 7T90_refined | 3.3 | A | Active | 100 | 59 | Gi/o | αo | - | 62 | - | scFv16 |
acetylcholine
|
small-molecule | Agonist | acetylcholine | small-molecule | No | No | - | - | 2023-01-25 | Yes | |
| ACM2 | M2 | Acetylcholine (muscarinic) | A | Human | Cryo-EM | 7T94 | - | 3.2 | A | Active | 100 | 57 | Gi/o | αo | - | 62 | - | Antibody fragment |
acetylcholine
LY2119620 |
small-molecule small-molecule |
Agonist PAM |
acetylcholine | small-molecule | No | No | - | - | 2023-01-25 | Yes | |
| ACM2 | M2 | Acetylcholine (muscarinic) | A | Human | Cryo-EM | 7T96 | 7T96_refined | 3.2 | A | Active | 100 | 59 | Gi/o | αo | - | 62 | - | scFv16 |
acetylcholine
LY2119620 |
small-molecule small-molecule |
Agonist PAM |
acetylcholine | small-molecule | No | No | - | - | 2023-01-25 | Yes | |
| ACM2 | M2 | Acetylcholine (muscarinic) | A | Human | Cryo-EM | 7T8X | 7T8X_refined | 3.2 | A | Active | 100 | 59 | Gi/o | αo | - | 62 | - | Antibody fragment |
acetylcholine
|
small-molecule | Agonist | acetylcholine | small-molecule | No | No | - | - | 2023-01-25 | Yes | |
| AA2BR | A2B | Adenosine | A | Human | Cryo-EM | 8HDO | - | 2.9 | R | Active | 100 | 83 | Gs | αs | Mini-Gs | 59 | - | Nanobody-35 |
BAY 60-6583
|
small-molecule | Agonist | adenosine | small-molecule | No | No | Cai H, Xu Y, Guo S, He X, Sun J, Li X, Li C, Yin W, Cheng X, Jiang H, Xu HE, Xie X, Jiang Y | 10.1038/S41421-022-00503-1 | 2023-01-18 | Yes | |
| AA2BR | A2B | Adenosine | A | Human | Cryo-EM | 8HDP | - | 3.2 | R | Active | 100 | 84 | Gs | αs | Mini-Gs | 60 | - | Nanobody-35 |
adenosine
|
small-molecule | Agonist | adenosine | small-molecule | No | No | Cai H, Xu Y, Guo S, He X, Sun J, Li X, Li C, Yin W, Cheng X, Jiang H, Xu HE, Xie X, Jiang Y | 10.1038/S41421-022-00503-1 | 2023-01-18 | Yes | |
| ACTHR | MC2 | Melanocortin | A | Human | Cryo-EM | 8GY7 | - | 3.3 | R | Active | 100 | 92 | Gs | αs | - | 59 | BRIL | - |
ACTH
|
peptide | Agonist | ACTH | peptide | No | No | Luo P, Feng W, Ma S, Dai A, Wu K, Chen X, Yuan Q, Cai X, Yang D, Wang MW, Eric Xu H, Jiang Y | 10.1038/S41422-022-00751-6 | 2023-01-11 | Yes | |
| TRFR | TRH1 | Thyrotropin-releasing hormone | A | Human | Cryo-EM | 7XW9 | - | 2.7 | R | Active | 100 | 72 | Gq/11 | αq | - | 58 | - | scFv16 |
TRH
|
peptide | Agonist | TRH | peptide | No | No | - | - | 2022-12-28 | Yes | |
| GP119 | GPR119 | GPR18, GPR55 and GPR119 | A | Human | Cryo-EM | 7WCN | 7WCN_refined | 2.9 | R | Active | 100 | 86 | Gs | αs | - | 60 | - | Nanobody-35 |
AR231453
|
small-molecule | Agonist | N-oleoylethanolamide, N-palmitoylethanolamine, SEA, anandamide | small-molecule | No | No | Qian Y, Wang J, Yang L, Liu Y, Wang L, Liu W, Lin Y, Yang H, Ma L, Ye S, Wu S, Qiao A | 10.1038/S41467-022-34696-6 | 2022-12-21 | Yes | |
| GP119 | GPR119 | GPR18, GPR55 and GPR119 | A | Human | Cryo-EM | 7WCM | 7WCM_refined | 2.3 | R | Active | 100 | 86 | Gs | αs | - | 60 | - | Nanobody-35 |
MBX-2982
|
small-molecule | Agonist | N-oleoylethanolamide, N-palmitoylethanolamine, SEA, anandamide | small-molecule | No | No | Qian Y, Wang J, Yang L, Liu Y, Wang L, Liu W, Lin Y, Yang H, Ma L, Ye S, Wu S, Qiao A | 10.1038/S41467-022-34696-6 | 2022-12-21 | Yes | |
| PTH1R | PTH1 | Parathyroid hormone | B1 | Human | Cryo-EM | 8HAO | - | 3.8 | R | Active | 100 | 61 | Gs | αs | - | 60 | - | Nanobody-35 |
teriparatide
|
peptide | Agonist | PTH, PTHrP, TIP39, PTHrP-(1-36) | peptide | No | No | Zhao LH, Yuan QN, Dai AT, He XH, Chen CW, Zhang C, Xu YW, Zhou Y, Wang MW, Yang DH, Xu HE | 10.1038/S41401-022-01032-Z | 2022-12-21 | Yes | |
| PTH1R | PTH1 | Parathyroid hormone | B1 | Human | Cryo-EM | 8HA0 | - | 2.6 | R | Active | 100 | 61 | Gs | αs | - | 60 | - | Nanobody-35 |
teriparatide
|
peptide | Agonist | PTH, PTHrP, TIP39, PTHrP-(1-36) | peptide | No | No | Zhao LH, Yuan QN, Dai AT, He XH, Chen CW, Zhang C, Xu YW, Zhou Y, Wang MW, Yang DH, Xu HE | 10.1038/S41401-022-01032-Z | 2022-12-21 | Yes | |
| PTH1R | PTH1 | Parathyroid hormone | B1 | Human | Cryo-EM | 8HAF | - | 3.3 | R | Active | 100 | 62 | Gs | αs | - | 60 | - | Nanobody-35 |
PTHrP-(1-36)
|
peptide | Agonist | PTH, PTHrP, TIP39, PTHrP-(1-36) | peptide | No | No | Zhao LH, Yuan QN, Dai AT, He XH, Chen CW, Zhang C, Xu YW, Zhou Y, Wang MW, Yang DH, Xu HE | 10.1038/S41401-022-01032-Z | 2022-12-21 | Yes | |
| OPRD | δ | Opioid | A | Human | Cryo-EM | 8F7S | 8F7S_refined | 3.0 | R | Active | 100 | 78 | Gi/o | αi1 | - | 62 | - | - |
DELTORPHIN II
|
protein | Agonist | dynorphin B, dynorphin A-(1-13), dynorphin A-(1-8), β-endorphin, α-neoendorphin, [Met]enkephalin, dynorphin A, [Leu]enkephalin, endomorphin-1 | peptide | No | No | Wang Y, Zhuang Y, DiBerto JF, Zhou XE, Schmitz GP, Yuan Q, Jain MK, Liu W, Melcher K, Jiang Y, Roth BL, Xu HE | 10.1016/J.CELL.2022.12.026 | 2022-12-14 | Yes | |
| OPRK | κ | Opioid | A | Human | Cryo-EM | 8F7W | 8F7W_refined | 3.2 | R | Active | 100 | 75 | Gi/o | αi1 | - | 64 | - | scFv16 |
dynorphin A-(1-8)
|
peptide | Agonist | dynorphin B, dynorphin A-(1-13), dynorphin A-(1-8), β-endorphin, β-neoendorphin, α-neoendorphin, [Met]enkephalin, dynorphin A, [Leu]enkephalin, big dynorphin | peptide | No | No | Wang Y, Zhuang Y, DiBerto JF, Zhou XE, Schmitz GP, Yuan Q, Jain MK, Liu W, Melcher K, Jiang Y, Roth BL, Xu HE | 10.1016/J.CELL.2022.12.026 | 2022-12-14 | Yes | |
| OPRM | μ | Opioid | A | Human | Cryo-EM | 8F7Q | - | 3.2 | R | Active | 100 | 72 | Gi/o | αi1 | - | 64 | - | scFv16 |
β-endorphin
|
peptide | Agonist | dynorphin B, dynorphin A-(1-13), dynorphin A-(1-8), β-endorphin, [Met]enkephalin, dynorphin A, [Leu]enkephalin, endomorphin-1, endomorphin-2 | peptide | No | No | Wang Y, Zhuang Y, DiBerto JF, Zhou XE, Schmitz GP, Yuan Q, Jain MK, Liu W, Melcher K, Jiang Y, Roth BL, Xu HE | 10.1016/J.CELL.2022.12.026 | 2022-12-14 | Yes | |
| OPRM | μ | Opioid | A | Human | Cryo-EM | 8F7R | - | 3.3 | R | Active | 100 | 72 | Gi/o | αi1 | - | 63 | - | scFv16 |
endomorphin-1
|
peptide | Agonist | dynorphin B, dynorphin A-(1-13), dynorphin A-(1-8), β-endorphin, [Met]enkephalin, dynorphin A, [Leu]enkephalin, endomorphin-1, endomorphin-2 | peptide | No | No | Wang Y, Zhuang Y, DiBerto JF, Zhou XE, Schmitz GP, Yuan Q, Jain MK, Liu W, Melcher K, Jiang Y, Roth BL, Xu HE | 10.1016/J.CELL.2022.12.026 | 2022-12-14 | Yes | |
| OPRX | NOP | Opioid | A | Human | Cryo-EM | 8F7X | 8F7X_refined | 3.3 | R | Active | 100 | 77 | Gi/o | αi1 | - | 62 | - | scFv16 |
nociceptin/orphanin FQ
|
peptide | Agonist | nociceptin/orphanin FQ | peptide | No | No | Wang Y, Zhuang Y, DiBerto JF, Zhou XE, Schmitz GP, Yuan Q, Jain MK, Liu W, Melcher K, Jiang Y, Roth BL, Xu HE | 10.1016/J.CELL.2022.12.026 | 2022-12-14 | Yes | |
| OPRM | μ | Opioid | A | Mouse | Cryo-EM | 7T2H | - | 3.2 | D | Active | 100 | 71 | Gi/o | αi1 | - | 61 | - | scFv16 |
LOFENTANIL
|
small-molecule | Agonist | - | - | No | No | Qu Q, Huang W, Aydin D, Paggi JM, Seven AB, Wang H, Chakraborty S, Che T, DiBerto JF, Robertson MJ, Inoue A, Suomivuori CM, Roth BL, Majumdar S, Dror RO, Kobilka BK, Skiniotis G | 10.1038/S41589-022-01208-Y | 2022-12-07 | Yes | |
| OPRM | μ | Opioid | A | Mouse | Cryo-EM | 7U2K | - | 3.3 | D | Active | 100 | 71 | Gi/o | αi1 | - | 61 | - | - |
CHEMBL147044
|
small-molecule | Agonist | - | - | No | No | Faouzi A, Wang H, Zaidi SA, DiBerto JF, Che T, Qu Q, Robertson MJ, Madasu MK, El Daibani A, Varga BR, Zhang T, Ruiz C, Liu S, Xu J, Appourchaux K, Slocum ST, Eans SO, Cameron MD, Al-Hasani R, Pan YX, Roth BL, McLaughlin JP, Skiniotis G, Katritch V, Kobilka BK, Majumdar S | 10.1038/S41586-022-05588-Y | 2022-12-07 | Yes | |
| OPRM | μ | Opioid | A | Mouse | Cryo-EM | 7T2G | - | 2.5 | R | Active | 100 | 70 | Gi/o | αi1 | - | 62 | BRIL | - |
CHEMBL58362
|
small-molecule | Agonist | - | - | No | No | Qu Q, Huang W, Aydin D, Paggi JM, Seven AB, Wang H, Chakraborty S, Che T, DiBerto JF, Robertson MJ, Inoue A, Suomivuori CM, Roth BL, Majumdar S, Dror RO, Kobilka BK, Skiniotis G | 10.1038/S41589-022-01208-Y | 2022-12-07 | Yes | |
| ACM3 | M3 | Acetylcholine (muscarinic) | A | Human | Cryo-EM | 8EA0 | 8EA0_refined | 2.6 | A | Active | 99 | 48 | - | - | - | - | - | - |
iperoxo
|
small-molecule | Agonist | acetylcholine | small-molecule | No | No | Zhang S, Gumpper RH, Huang XP, Liu Y, Krumm BE, Cao C, Fay JF, Roth BL | 10.1038/S41586-022-05489-0 | 2022-11-30 | Yes | |
| ACM3 | M3 | Acetylcholine (muscarinic) | A | Human | Cryo-EM | 8E9Y | - | 2.8 | A | Active | 100 | 47 | Gq/11 | αq | Mini-Gq | 56 | - | scFv16 |
Clozapine N-oxide
|
small-molecule | Agonist | acetylcholine | small-molecule | No | No | Zhang S, Gumpper RH, Huang XP, Liu Y, Krumm BE, Cao C, Fay JF, Roth BL | 10.1038/S41586-022-05489-0 | 2022-11-30 | Yes | |
| ACM3 | M3 | Acetylcholine (muscarinic) | A | Human | Cryo-EM | 8E9W | - | 2.7 | A | Active | 100 | 47 | Gq/11 | αq | Mini-Gq | 57 | - | scFv16 |
CHEMBL73538
|
small-molecule | Agonist | acetylcholine | small-molecule | No | No | Zhang S, Gumpper RH, Huang XP, Liu Y, Krumm BE, Cao C, Fay JF, Roth BL | 10.1038/S41586-022-05489-0 | 2022-11-30 | Yes | |
| ACM3 | M3 | Acetylcholine (muscarinic) | A | Human | Cryo-EM | 8E9Z | - | 2.7 | A | Active | 100 | 47 | Gq/11 | αq | Mini-Gq | 57 | - | scFv16 |
iperoxo
|
small-molecule | Agonist | acetylcholine | small-molecule | No | No | Zhang S, Gumpper RH, Huang XP, Liu Y, Krumm BE, Cao C, Fay JF, Roth BL | 10.1038/S41586-022-05489-0 | 2022-11-30 | Yes | |
| ACM4 | M4 | Acetylcholine (muscarinic) | A | Human | Cryo-EM | 8E9X | - | 2.7 | A | Active | 100 | 57 | Gi/o | αo | Mini-Go | 61 | - | scFv16 |
CHEMBL73538
|
small-molecule | Agonist | acetylcholine | small-molecule | No | No | Zhang S, Gumpper RH, Huang XP, Liu Y, Krumm BE, Cao C, Fay JF, Roth BL | 10.1038/S41586-022-05489-0 | 2022-11-30 | Yes | |
| OX2R | OX2 | Orexin | A | Human | X-ray | 7XRR | 7XRR_refined | 2.9 | A | Inactive | 1 | 70 | - | - | - | - | - | - |
lemborexant
|
small-molecule | Antagonist | orexin-B, orexin-A | peptide | No | No | Asada H, Im D, Hotta Y, Yasuda S, Murata T, Suno R, Iwata S | 10.1016/J.STR.2022.11.001 | 2022-11-23 | Yes | |
| PACR | PAC1 | VIP and PACAP | B1 | Human | Cryo-EM | 8E3X | 8E3X_refined | 2.3 | R | Active | 100 | 77 | Gs | αs | - | 59 | - | Nanobody-35 |
[Ac-His1]PACAP-27
|
peptide | Agonist | PHM, PACAP-27, VIP, PHV, PACAP-38, PHI | peptide | No | No | Piper SJ, Deganutti G, Lu J, Zhao P, Liang YL, Lu Y, Fletcher MM, Hossain MA, Christopoulos A, Reynolds CA, Danev R, Sexton PM, Wootten D | 10.1038/S41467-022-34629-3 | 2022-11-23 | Yes | |
| VIPR1 | VPAC1 | VIP and PACAP | B1 | Human | Cryo-EM | 8E3Z | 8E3Z_refined | 2.7 | R | Active | 100 | 81 | Gs | αs | - | 55 | - | Nanobody-35 |
Vasoactive intestinal polypeptide
|
small-molecule | Agonist | secretin, PHM, PACAP-27, VIP, PACAP-38, PHI, GHRH | peptide | No | No | Piper SJ, Deganutti G, Lu J, Zhao P, Liang YL, Lu Y, Fletcher MM, Hossain MA, Christopoulos A, Reynolds CA, Danev R, Sexton PM, Wootten D | 10.1038/S41467-022-34629-3 | 2022-11-23 | Yes | |
| VIPR1 | VPAC1 | VIP and PACAP | B1 | Human | Cryo-EM | 8E3Y | - | 2.3 | R | Active | 100 | 81 | Gs | αs | - | 56 | - | Nanobody-35 |
[Ac-His1]PACAP-27
|
peptide | Agonist | secretin, PHM, PACAP-27, VIP, PACAP-38, PHI, GHRH | peptide | No | No | Piper SJ, Deganutti G, Lu J, Zhao P, Liang YL, Lu Y, Fletcher MM, Hossain MA, Christopoulos A, Reynolds CA, Danev R, Sexton PM, Wootten D | 10.1038/S41467-022-34629-3 | 2022-11-23 | Yes | |
| AGRL3 | ADGRL3 | ADGRL | B2 | Mouse | Cryo-EM | 7X10 | - | 2.9 | R | Active | 100 | 17 | G12/13 | α12 | - | 55 | - | scFv16 |
Apo (no ligand)
|
none | Apo (no ligand) | - | - | No | No | Qian Y, Ma Z, Liu C, Li X, Zhu X, Wang N, Xu Z, Xia R, Liang J, Duan Y, Yin H, Xiong Y, Zhang A, Guo C, Chen Z, Huang Z, He Y | 10.1016/J.MOLCEL.2022.10.009 | 2022-11-09 | Yes | |
| CRFR2 | CRF2 | Corticotropin-releasing factor | B1 | Human | Cryo-EM | 7TRY | - | 3.7 | P | Active | 100 | 79 | Gq/11 | α11 | - | 62 | - | - |
Urocortin
|
peptide | Agonist | urocortin 1, urocortin 3, urocortin 2, corticotrophin-releasing hormone | peptide | No | No | Zhao LH, Lin J, Ji SY, Zhou XE, Mao C, Shen DD, He X, Xiao P, Sun J, Melcher K, Zhang Y, Yu X, Xu HE | 10.1038/S41467-022-33851-3 | 2022-11-09 | Yes | |
| CRFR2 | CRF2 | Corticotropin-releasing factor | B1 | Human | Cryo-EM | 7TS0 | 7TS0_refined | 2.8 | P | Active | 100 | 72 | Gi/o | αo | - | 63 | - | scFv16 |
Urocortin
|
peptide | Agonist | urocortin 1, urocortin 3, urocortin 2, corticotrophin-releasing hormone | peptide | No | No | Zhao LH, Lin J, Ji SY, Zhou XE, Mao C, Shen DD, He X, Xiao P, Sun J, Melcher K, Zhang Y, Yu X, Xu HE | 10.1038/S41467-022-33851-3 | 2022-11-09 | Yes | |
| OPRM | μ | Opioid | A | Human | Cryo-EM | 8EFL | 8EFL_refined | 3.2 | R | Active | 100 | 72 | Gi/o | αi1 | - | 64 | - | scFv16 |
CHEMBL4452384
|
small-molecule | Agonist | dynorphin B, dynorphin A-(1-13), dynorphin A-(1-8), β-endorphin, [Met]enkephalin, dynorphin A, [Leu]enkephalin, endomorphin-1, endomorphin-2 | peptide | No | No | Zhuang Y, Wang Y, He B, He X, Zhou XE, Guo S, Rao Q, Yang J, Liu J, Zhou Q, Wang X, Liu M, Liu W, Jiang X, Yang D, Jiang H, Shen J, Melcher K, Chen H, Jiang Y, Cheng X, Wang MW, Xie X, Xu HE | 10.1016/J.CELL.2022.09.041 | 2022-11-09 | Yes | |
| OPRM | μ | Opioid | A | Human | Cryo-EM | 8EF5 | - | 3.3 | R | Active | 100 | 72 | Gi/o | αi1 | - | 64 | - | scFv16 |
fentanyl
|
small-molecule | Agonist | dynorphin B, dynorphin A-(1-13), dynorphin A-(1-8), β-endorphin, [Met]enkephalin, dynorphin A, [Leu]enkephalin, endomorphin-1, endomorphin-2 | peptide | No | No | Zhuang Y, Wang Y, He B, He X, Zhou XE, Guo S, Rao Q, Yang J, Liu J, Zhou Q, Wang X, Liu M, Liu W, Jiang X, Yang D, Jiang H, Shen J, Melcher K, Chen H, Jiang Y, Cheng X, Wang MW, Xie X, Xu HE | 10.1016/J.CELL.2022.09.041 | 2022-11-09 | Yes | |
| OPRM | μ | Opioid | A | Human | Cryo-EM | 8EFO | - | 2.8 | R | Active | 100 | 72 | Gi/o | αi1 | - | 64 | - | scFv16 |
PZM21
|
small-molecule | Agonist | dynorphin B, dynorphin A-(1-13), dynorphin A-(1-8), β-endorphin, [Met]enkephalin, dynorphin A, [Leu]enkephalin, endomorphin-1, endomorphin-2 | peptide | No | No | Zhuang Y, Wang Y, He B, He X, Zhou XE, Guo S, Rao Q, Yang J, Liu J, Zhou Q, Wang X, Liu M, Liu W, Jiang X, Yang D, Jiang H, Shen J, Melcher K, Chen H, Jiang Y, Cheng X, Wang MW, Xie X, Xu HE | 10.1016/J.CELL.2022.09.041 | 2022-11-09 | Yes | |
| OPRM | μ | Opioid | A | Human | Cryo-EM | 8EF6 | 8EF6_refined | 3.2 | R | Active | 100 | 72 | Gi/o | αi1 | - | 64 | - | scFv16 |
morphine
|
small-molecule | Agonist | dynorphin B, dynorphin A-(1-13), dynorphin A-(1-8), β-endorphin, [Met]enkephalin, dynorphin A, [Leu]enkephalin, endomorphin-1, endomorphin-2 | peptide | No | No | Zhuang Y, Wang Y, He B, He X, Zhou XE, Guo S, Rao Q, Yang J, Liu J, Zhou Q, Wang X, Liu M, Liu W, Jiang X, Yang D, Jiang H, Shen J, Melcher K, Chen H, Jiang Y, Cheng X, Wang MW, Xie X, Xu HE | 10.1016/J.CELL.2022.09.041 | 2022-11-09 | Yes | |
| OPRM | μ | Opioid | A | Human | Cryo-EM | 8EFQ | - | 3.3 | R | Active | 100 | 71 | Gi/o | αi1 | - | 61 | - | - |
DAMGO
|
peptide | Agonist | dynorphin B, dynorphin A-(1-13), dynorphin A-(1-8), β-endorphin, [Met]enkephalin, dynorphin A, [Leu]enkephalin, endomorphin-1, endomorphin-2 | peptide | No | No | Zhuang Y, Wang Y, He B, He X, Zhou XE, Guo S, Rao Q, Yang J, Liu J, Zhou Q, Wang X, Liu M, Liu W, Jiang X, Yang D, Jiang H, Shen J, Melcher K, Chen H, Jiang Y, Cheng X, Wang MW, Xie X, Xu HE | 10.1016/J.CELL.2022.09.041 | 2022-11-09 | Yes | |
| OPRM | μ | Opioid | A | Human | Cryo-EM | 8EFB | 8EFB_refined | 3.2 | R | Active | 100 | 71 | Gi/o | αi1 | - | 64 | - | scFv16 |
OLICERIDINE
|
small-molecule | Agonist | dynorphin B, dynorphin A-(1-13), dynorphin A-(1-8), β-endorphin, [Met]enkephalin, dynorphin A, [Leu]enkephalin, endomorphin-1, endomorphin-2 | peptide | No | No | Zhuang Y, Wang Y, He B, He X, Zhou XE, Guo S, Rao Q, Yang J, Liu J, Zhou Q, Wang X, Liu M, Liu W, Jiang X, Yang D, Jiang H, Shen J, Melcher K, Chen H, Jiang Y, Cheng X, Wang MW, Xie X, Xu HE | 10.1016/J.CELL.2022.09.041 | 2022-11-09 | Yes | |
| MRGX1 | MRGPRX1 | A orphans | A | Human | Cryo-EM | 8DWC | - | 2.9 | R | Active | 100 | 78 | Gq/11 | αq | Gs-mini-Gq chimera | 57 | - | scFv16 |
Proenkephalin-A
|
peptide | Agonist | bovine adrenal medulla peptide 8-22 | peptide | No | No | Liu Y, Cao C, Huang XP, Gumpper RH, Rachman MM, Shih SL, Krumm BE, Zhang S, Shoichet BK, Fay JF, Roth BL | 10.1038/S41589-022-01173-6 | 2022-11-02 | Yes | |
| MRGX1 | MRGPRX1 | A orphans | A | Human | Cryo-EM | 8DWH | 8DWH_refined | 3.3 | R | Active | 100 | 77 | Gq/11 | αq | Gs-mini-Gq chimera | 57 | - | - |
compound 16 [PMID: 31498617]
|
small-molecule | Agonist | bovine adrenal medulla peptide 8-22 | peptide | No | No | Liu Y, Cao C, Huang XP, Gumpper RH, Rachman MM, Shih SL, Krumm BE, Zhang S, Shoichet BK, Fay JF, Roth BL | 10.1038/S41589-022-01173-6 | 2022-11-02 | Yes | |
| MRGX1 | MRGPRX1 | A orphans | A | Human | Cryo-EM | 8DWG | - | 2.7 | R | Active | 100 | 77 | Gq/11 | αq | Gs-mini-Gq chimera | 57 | - | scFv16 |
Proenkephalin-A
CHEMBL5177388 |
peptide small-molecule |
Agonist PAM |
bovine adrenal medulla peptide 8-22 | peptide | No | No | Liu Y, Cao C, Huang XP, Gumpper RH, Rachman MM, Shih SL, Krumm BE, Zhang S, Shoichet BK, Fay JF, Roth BL | 10.1038/S41589-022-01173-6 | 2022-11-02 | Yes | |
| P2Y12 | P2Y12 | P2Y | A | Human | X-ray | 7PP1 | - | 2.8 | A | Active | 56 | 78 | - | - | - | - | BRIL | - |
selatogrel
|
small-molecule | Antagonist | ADP, ATP | small-molecule | No | No | Pons V, Garcia C, Tidten-Luksch N, Mac Sweeney A, Caroff E, Gales C, Riederer MA | 10.1016/j.bcp.2022.115291 | 2022-11-02 | Yes | |
| AGRL3 | ADGRL3 | ADGRL | B2 | Mouse | Cryo-EM | 7WYB | - | 3.0 | R | Active | 100 | 17 | Gi/o | αi1 | - | 64 | - | scFv16 |
Apo (no ligand)
|
none | Apo (no ligand) | - | - | No | No | Qian Y, Ma Z, Liu C, Li X, Zhu X, Wang N, Xu Z, Xia R, Liang J, Duan Y, Yin H, Xiong Y, Zhang A, Guo C, Chen Z, Huang Z, He Y | 10.1016/J.MOLCEL.2022.10.009 | 2022-10-26 | Yes | |
| AGRL3 | ADGRL3 | ADGRL | B2 | Mouse | Cryo-EM | 7WY5 | - | 2.8 | R | Active | 100 | 17 | Gq/11 | αq | Mini-Gq | 59 | - | Nanobody-35 |
Apo (no ligand)
|
none | Apo (no ligand) | - | - | No | No | Qian Y, Ma Z, Liu C, Li X, Zhu X, Wang N, Xu Z, Xia R, Liang J, Duan Y, Yin H, Xiong Y, Zhang A, Guo C, Chen Z, Huang Z, He Y | 10.1016/J.MOLCEL.2022.10.009 | 2022-10-26 | Yes | |
| AGRL3 | ADGRL3 | ADGRL | B2 | Mouse | Cryo-EM | 7WY8 | - | 2.8 | R | Active | 100 | 17 | Gs | αs | Mini-Gs | 59 | - | Nanobody-35 |
Apo (no ligand)
|
none | Apo (no ligand) | - | - | No | No | Qian Y, Ma Z, Liu C, Li X, Zhu X, Wang N, Xu Z, Xia R, Liang J, Duan Y, Yin H, Xiong Y, Zhang A, Guo C, Chen Z, Huang Z, He Y | 10.1016/J.MOLCEL.2022.10.009 | 2022-10-26 | Yes | |
| GPR88 | GPR88 | A orphans | A | Human | Cryo-EM | 7WZ4 | - | 3.0 | R | Active | 100 | 61 | Gi/o | αi1 | - | 61 | - | scFv16 |
Apo (no ligand)
|
none | Apo (no ligand) | - | - | No | No | Chen G, Xu J, Inoue A, Schmidt MF, Bai C, Lu Q, Gmeiner P, Liu Z, Du Y | 10.1038/S41467-022-30081-5 | 2022-10-26 | Yes | |
| HRH3 | H3 | Histamine | A | Human | X-ray | 7F61 | 7F61_refined | 2.6 | A | Inactive | 12 | 68 | - | - | - | - | BRIL | - |
N-ethyl-3-fluoro-3-[3-fluoro-4-(pyrrolidin-1-ylmethyl)phenyl]cyclobutane-1-carboxamide
|
small-molecule | Antagonist | histamine | small-molecule | No | No | Peng X, Yang L, Liu Z, Lou S, Mei S, Li M, Chen Z, Zhang H | 10.1038/S41467-022-33880-Y | 2022-10-26 | Yes | |
| SSR2 | SST2 | Somatostatin | A | Human | Cryo-EM | 7Y27 | 7Y27_refined | 3.5 | E | Active | 100 | 74 | Gq/11 | αq | Mini-Gq | 60 | - | scFv16 |
SOMATOSTATIN
|
protein | Agonist | CST-17, SRIF-14, cortistatin-14, SRIF-28 | peptide | No | No | Chen S, Teng X, Zheng S | 10.1038/S41589-022-01130-3 | 2022-10-19 | Yes | |
| SSR2 | SST2 | Somatostatin | A | Human | Cryo-EM | 7Y24 | - | 3.3 | E | Active | 100 | 77 | Gi/o | αo | - | 60 | - | scFv16 |
Octreotide
|
peptide | Agonist | CST-17, SRIF-14, cortistatin-14, SRIF-28 | peptide | No | No | Chen S, Teng X, Zheng S | 10.1038/S41589-022-01130-3 | 2022-10-19 | Yes | |
| SSR2 | SST2 | Somatostatin | A | Human | Cryo-EM | 7Y26 | 7Y26_refined | 3.3 | E | Active | 100 | 73 | Gq/11 | αq | Mini-Gq | 60 | - | scFv16 |
Octreotide
|
peptide | Agonist | CST-17, SRIF-14, cortistatin-14, SRIF-28 | peptide | No | No | Chen S, Teng X, Zheng S | 10.1038/S41589-022-01130-3 | 2022-10-19 | Yes | |
| GPR17 | GPR17 | A orphans | A | Human | Cryo-EM | 7Y89 | - | 3.0 | A | Active | 100 | 78 | Gi/o | αi1 | - | 58 | - | - |
Apo (no ligand)
|
none | Apo (no ligand) | UDP-glucose, LTC4, ATP, LTE4, UDP-galactose, UDP, LTD4 | small-molecule | No | No | Ye F, Wong TS, Chen G, Zhang Z, Zhang B, Gan S, Gao W, Li J, Wu Z, Pan X, Du Y | 10.1002/MCO2.159 | 2022-10-12 | Yes | |
| T2R46 | TAS2R46 | Taste 2 | T2 | Human | Cryo-EM | 7XP5 | - | 3.1 | R | Active | 100 | 97 | Gi/o | αgust | - | 63 | - | Nanobody-35 |
Apo (no ligand)
|
none | Apo (no ligand) | - | - | No | No | Xu W, Wu L, Liu S, Liu X, Cao X, Zhou C, Zhang J, Fu Y, Guo Y, Wu Y, Tan Q, Wang L, Liu J, Jiang L, Fan Z, Pei Y, Yu J, Cheng J, Zhao S, Hao X, Liu ZJ, Hua T | 10.1126/SCIENCE.ABO1633 | 2022-10-12 | Yes | |
| T2R46 | TAS2R46 | Taste 2 | T2 | Human | Cryo-EM | 7XP6 | - | 3.0 | R | Active | 100 | 92 | Gi/o | αgust | - | 63 | - | Nanobody-35 |
strychnine
|
small-molecule | Agonist | - | - | No | No | Xu W, Wu L, Liu S, Liu X, Cao X, Zhou C, Zhang J, Fu Y, Guo Y, Wu Y, Tan Q, Wang L, Liu J, Jiang L, Fan Z, Pei Y, Yu J, Cheng J, Zhao S, Hao X, Liu ZJ, Hua T | 10.1126/SCIENCE.ABO1633 | 2022-10-12 | Yes | |
| T2R46 | TAS2R46 | Taste 2 | T2 | Human | Cryo-EM | 7XP4 | - | 3.0 | R | Active | 100 | 97 | Gi/o | αgust | - | 63 | - | Nanobody-35 |
Apo (no ligand)
|
none | Apo (no ligand) | - | - | No | No | Xu W, Wu L, Liu S, Liu X, Cao X, Zhou C, Zhang J, Fu Y, Guo Y, Wu Y, Tan Q, Wang L, Liu J, Jiang L, Fan Z, Pei Y, Yu J, Cheng J, Zhao S, Hao X, Liu ZJ, Hua T | 10.1126/SCIENCE.ABO1633 | 2022-10-12 | Yes | |
| LPAR1 | LPA1 | Lysophospholipid (LPA) | A | Human | Cryo-EM | 7YU8 | - | 4.5 | R | Active | 100 | 80 | Gi/o | αi1 | - | 63 | - | scFv16 |
[(2~{R})-2-[5-(2-hexylphenyl)pentanoylamino]-3-oxidanyl-propyl] dihydrogen phosphate
|
small-molecule | Agonist | 1-O-Oleoyl-D-glycerol 3-phosphoric acid | small-molecule | No | No | Akasaka H, Tanaka T, Sano FK, Matsuzaki Y, Shihoya W, Nureki O | 10.1038/S41467-022-33121-2 | 2022-10-05 | Yes | |
| LPAR1 | LPA1 | Lysophospholipid (LPA) | A | Human | Cryo-EM | 7YU3 | 7YU3_refined | 3.4 | R | Active | 100 | 80 | Gi/o | αi1 | - | 63 | - | scFv16 |
[(2~{R})-2-[5-(2-hexylphenyl)pentanoylamino]-3-oxidanyl-propyl] dihydrogen phosphate
|
small-molecule | Agonist | 1-O-Oleoyl-D-glycerol 3-phosphoric acid | small-molecule | No | No | Akasaka H, Tanaka T, Sano FK, Matsuzaki Y, Shihoya W, Nureki O | 10.1038/S41467-022-33121-2 | 2022-10-05 | Yes | |
| LPAR1 | LPA1 | Lysophospholipid (LPA) | A | Human | Cryo-EM | 7YU4 | 7YU4_refined | 3.3 | A | Active | 99 | 73 | - | - | - | - | - | - |
[(2~{R})-2-[5-(2-hexylphenyl)pentanoylamino]-3-oxidanyl-propyl] dihydrogen phosphate
|
small-molecule | Agonist | 1-O-Oleoyl-D-glycerol 3-phosphoric acid | small-molecule | No | No | Akasaka H, Tanaka T, Sano FK, Matsuzaki Y, Shihoya W, Nureki O | 10.1038/S41467-022-33121-2 | 2022-10-05 | Yes | |
| LPAR1 | LPA1 | Lysophospholipid (LPA) | A | Human | Cryo-EM | 7YU5 | 7YU5_refined | 3.3 | R | Active | 100 | 80 | Gi/o | αi1 | - | 63 | - | scFv16 |
[(2~{R})-2-[5-(2-hexylphenyl)pentanoylamino]-3-oxidanyl-propyl] dihydrogen phosphate
|
small-molecule | Agonist | 1-O-Oleoyl-D-glycerol 3-phosphoric acid | small-molecule | No | No | Akasaka H, Tanaka T, Sano FK, Matsuzaki Y, Shihoya W, Nureki O | 10.1038/S41467-022-33121-2 | 2022-10-05 | Yes | |
| LPAR1 | LPA1 | Lysophospholipid (LPA) | A | Human | Cryo-EM | 7YU6 | 7YU6_refined | 3.5 | R | Active | 100 | 80 | Gi/o | αi1 | - | 63 | - | scFv16 |
[(2~{R})-2-[5-(2-hexylphenyl)pentanoylamino]-3-oxidanyl-propyl] dihydrogen phosphate
|
small-molecule | Agonist | 1-O-Oleoyl-D-glycerol 3-phosphoric acid | small-molecule | No | No | Akasaka H, Tanaka T, Sano FK, Matsuzaki Y, Shihoya W, Nureki O | 10.1038/S41467-022-33121-2 | 2022-10-05 | Yes | |
| LPAR1 | LPA1 | Lysophospholipid (LPA) | A | Human | Cryo-EM | 7YU7 | - | 3.8 | R | Active | 100 | 80 | Gi/o | αi1 | - | 63 | - | scFv16 |
[(2~{R})-2-[5-(2-hexylphenyl)pentanoylamino]-3-oxidanyl-propyl] dihydrogen phosphate
|
small-molecule | Agonist | 1-O-Oleoyl-D-glycerol 3-phosphoric acid | small-molecule | No | No | Akasaka H, Tanaka T, Sano FK, Matsuzaki Y, Shihoya W, Nureki O | 10.1038/S41467-022-33121-2 | 2022-10-05 | Yes | |
| ADA2A | α2A | Adrenoceptors | A | Human | Cryo-EM | 7W6P | - | 3.5 | R | Active | 100 | 55 | Gi/o | αo | - | 58 | - | scFv16 |
N-pyridin-4-ylisoquinolin-4-amine
|
small-molecule | Agonist | (-)-adrenaline, (-)-noradrenaline | small-molecule | No | No | Fink EA, Xu J, Hubner H, Braz JM, Seemann P, Avet C, Craik V, Weikert D, Schmidt MF, Webb CM, Tolmachova NA, Moroz YS, Huang XP, Kalyanaraman C, Gahbauer S, Chen G, Liu Z, Jacobson MP, Irwin JJ, Bouvier M, Du Y, Shoichet BK, Basbaum AI, Gmeiner P | 10.1126/SCIENCE.ABN7065 | 2022-09-28 | Yes | |
| ADA2A | α2A | Adrenoceptors | A | Human | Cryo-EM | 7W7E | - | 3.4 | R | Active | 100 | 56 | Gi/o | αo | - | 59 | - | scFv16 |
5-(3-Bicyclo[4.2.0]octa-1,3,5-trienyl)-1,2,3,6-tetrahydropyridine
|
small-molecule | Agonist | (-)-adrenaline, (-)-noradrenaline | small-molecule | No | No | Fink EA, Xu J, Hubner H, Braz JM, Seemann P, Avet C, Craik V, Weikert D, Schmidt MF, Webb CM, Tolmachova NA, Moroz YS, Huang XP, Kalyanaraman C, Gahbauer S, Chen G, Liu Z, Jacobson MP, Irwin JJ, Bouvier M, Du Y, Shoichet BK, Basbaum AI, Gmeiner P | 10.1126/SCIENCE.ABN7065 | 2022-09-28 | Yes | |
| AGRF1 | ADGRF1 | ADGRF | B2 | Human | Cryo-EM | 7WXW | - | 2.8 | R | Active | 100 | 30 | Gs | αs | Mini-Gs | 59 | - | Nanobody-35 |
Apo (no ligand)
|
none | Apo (no ligand) | - | - | No | No | Zhu X, Qian Y, Li X, Xu Z, Xia R, Wang N, Liang J, Yin H, Zhang A, Guo C, Wang G, He Y | 10.1038/S41467-022-33173-4 | 2022-09-28 | Yes | |
| AGRF1 | ADGRF1 | ADGRF | B2 | Human | Cryo-EM | 7X2V | - | 3.1 | R | Active | 100 | 30 | Gi/o | αi1 | - | 62 | - | scFv16 |
Apo (no ligand)
|
none | Apo (no ligand) | - | - | No | No | Zhu X, Qian Y, Li X, Xu Z, Xia R, Wang N, Liang J, Yin H, Zhang A, Guo C, Wang G, He Y | 10.1038/S41467-022-33173-4 | 2022-09-28 | Yes | |
| AGRF1 | ADGRF1 | ADGRF | B2 | Human | Cryo-EM | 7WY0 | - | 2.8 | R | Active | 100 | 30 | G12/13 | α13 | - | 55 | - | scFv16 |
Apo (no ligand)
|
none | Apo (no ligand) | - | - | No | No | Zhu X, Qian Y, Li X, Xu Z, Xia R, Wang N, Liang J, Yin H, Zhang A, Guo C, Wang G, He Y | 10.1038/S41467-022-33173-4 | 2022-09-28 | Yes | |
| AGRF1 | ADGRF1 | ADGRF | B2 | Human | Cryo-EM | 7WXU | - | 2.9 | R | Active | 100 | 30 | Gq/11 | αq | - | 60 | - | Nanobody-35 |
Apo (no ligand)
|
none | Apo (no ligand) | - | - | No | No | Zhu X, Qian Y, Li X, Xu Z, Xia R, Wang N, Liang J, Yin H, Zhang A, Guo C, Wang G, He Y | 10.1038/S41467-022-33173-4 | 2022-09-28 | Yes | |
| AGRF1 | ADGRF1 | ADGRF | B2 | Human | Cryo-EM | 7WZ7 | - | 2.8 | R | Active | 100 | 30 | G12/13 | α12 | Mini-G12 | 55 | - | scFv16 |
Apo (no ligand)
|
none | Apo (no ligand) | - | - | No | No | Zhu X, Qian Y, Li X, Xu Z, Xia R, Wang N, Liang J, Yin H, Zhang A, Guo C, Wang G, He Y | 10.1038/S41467-022-33173-4 | 2022-09-28 | Yes | |
| S1PR1 | S1P1 | Lysophospholipid (S1P) | A | Human | Cryo-EM | 7VIH | 7VIH_refined | 3.0 | F | Active | 100 | 73 | Gi/o | αi1 | - | 64 | - | scFv16 |
icanbelimod
|
small-molecule | Agonist | dihydrosphingosine 1-phosphate, sphingosylphosphorylcholine, sphingosine 1-phosphate | small-molecule | No | No | Yu L, He L, Gan B, Ti R, Xiao Q, Hu H, Zhu L, Wang S, Ren R | 10.1073/PNAS.2117716119 | 2022-09-28 | Yes | |
| S1PR1 | S1P1 | Lysophospholipid (S1P) | A | Human | Cryo-EM | 7VIG | 7VIG_refined | 2.9 | F | Active | 100 | 73 | Gi/o | αi1 | - | 63 | - | scFv16 |
icanbelimod
|
small-molecule | Agonist | dihydrosphingosine 1-phosphate, sphingosylphosphorylcholine, sphingosine 1-phosphate | small-molecule | No | No | Yu L, He L, Gan B, Ti R, Xiao Q, Hu H, Zhu L, Wang S, Ren R | 10.1073/PNAS.2117716119 | 2022-09-28 | Yes | |
| S1PR1 | S1P1 | Lysophospholipid (S1P) | A | Human | Cryo-EM | 7VIE | 7VIE_refined | 2.9 | F | Active | 100 | 73 | Gi/o | αi1 | - | 64 | - | scFv16 |
sphingosine 1-phosphate
|
small-molecule | Agonist | dihydrosphingosine 1-phosphate, sphingosylphosphorylcholine, sphingosine 1-phosphate | small-molecule | No | No | Yu L, He L, Gan B, Ti R, Xiao Q, Hu H, Zhu L, Wang S, Ren R | 10.1073/PNAS.2117716119 | 2022-09-28 | Yes | |
| S1PR1 | S1P1 | Lysophospholipid (S1P) | A | Human | Cryo-EM | 7VIF | 7VIF_refined | 2.8 | F | Active | 100 | 73 | Gi/o | αi1 | - | 64 | - | scFv16 |
(S)-FTY720-phosphate
|
small-molecule | Agonist | dihydrosphingosine 1-phosphate, sphingosylphosphorylcholine, sphingosine 1-phosphate | small-molecule | No | No | Yu L, He L, Gan B, Ti R, Xiao Q, Hu H, Zhu L, Wang S, Ren R | 10.1073/PNAS.2117716119 | 2022-09-28 | Yes | |
| 5HT2B | 5-HT2B | 5-Hydroxytryptamine | A | Human | Cryo-EM | 7SRQ | 7SRQ_refined | 2.7 | R | Intermediate | 55 | 53 | - | - | - | - | - | - |
Lysergide
|
small-molecule | Agonist | 5-hydroxytryptamine | small-molecule | No | No | Cao C, Barros-Alvarez X, Zhang S, Kim K, Damgen MA, Panova O, Suomivuori CM, Fay JF, Zhong X, Krumm BE, Gumpper RH, Seven AB, Robertson MJ, Krogan NJ, Huttenhain R, Nichols DE, Dror RO, Skiniotis G, Roth BL | 10.1016/J.NEURON.2022.08.006 | 2022-09-21 | Yes | |
| 5HT2B | 5-HT2B | 5-Hydroxytryptamine | A | Human | Cryo-EM | 7SRS | - | 3.3 | R | Active | 100 | 60 | Beta | Beta-arrestin-1 | - | 85 | - | Fab light chain Fab heavy chain Fab30 heavy chain Fab30 light chain |
Lysergide
|
small-molecule | Agonist | 5-hydroxytryptamine | small-molecule | No | No | Cao C, Barros-Alvarez X, Zhang S, Kim K, Damgen MA, Panova O, Suomivuori CM, Fay JF, Zhong X, Krumm BE, Gumpper RH, Seven AB, Robertson MJ, Krogan NJ, Huttenhain R, Nichols DE, Dror RO, Skiniotis G, Roth BL | 10.1016/J.NEURON.2022.08.006 | 2022-09-21 | Yes | |
| 5HT2B | 5-HT2B | 5-Hydroxytryptamine | A | Human | Cryo-EM | 7SRR | - | 2.9 | R | Active | 100 | 57 | Gq/11 | αq | Gi2-mini-Gq chimera | 58 | - | scFv16 |
Lysergide
|
small-molecule | Agonist | 5-hydroxytryptamine | small-molecule | No | No | Cao C, Barros-Alvarez X, Zhang S, Kim K, Damgen MA, Panova O, Suomivuori CM, Fay JF, Zhong X, Krumm BE, Gumpper RH, Seven AB, Robertson MJ, Krogan NJ, Huttenhain R, Nichols DE, Dror RO, Skiniotis G, Roth BL | 10.1016/J.NEURON.2022.08.006 | 2022-09-21 | Yes | |
| FPR1 | FPR1 | Formylpeptide | A | Human | Cryo-EM | 7VFX | 7VFX_refined | 2.8 | R | Active | 100 | 84 | Gi/o | αi1 | - | 62 | - | scFv16 |
Peptide agonist fMet-Ile-Phe-Leu
|
peptide | Agonist | fMet-Leu-Phe, cathepsin G, spinorphin, annexin I | peptide | No | No | Chen G, Wang X, Liao Q, Ge Y, Jiao H, Chen Q, Liu Y, Lyu W, Zhu L, van Zundert GCP, Robertson MJ, Skiniotis G, Du Y, Hu H, Ye RD | 10.1038/S41467-022-32822-Y | 2022-09-21 | Yes | |
| 5HT5A | 5-HT5A | 5-Hydroxytryptamine | A | Human | Cryo-EM | 7X5H | 7X5H_refined | 3.1 | R | Active | 100 | 77 | Gi/o | αi1 | - | 63 | BRIL | scFv16 |
5-CT
|
small-molecule | Agonist | 5-hydroxytryptamine | small-molecule | No | No | Tan Y, Xu P, Huang S, Yang G, Zhou F, He X, Ma H, Xu HE, Jiang Y | 10.1038/S41421-022-00412-3 | 2022-09-14 | Yes | |
| V2R | V2 | Vasopressin and oxytocin | A | Human | Cryo-EM | 7R0C | - | 4.7 | A | Active | 100 | 76 | Beta | Beta-arrestin-1 | - | 84 | - | scFv30 |
vasopressin
|
peptide | Agonist | oxytocin, vasopressin | peptide | No | No | Bous J, Fouillen A, Orcel H, Trapani S, Cong X, Fontanel S, Saint-Paul J, Lai-Kee-Him J, Urbach S, Sibille N, Sounier R, Granier S, Mouillac B, Bron P | 10.1126/SCIADV.ABO7761 | 2022-09-14 | Yes | |
| AA2AR | A2A | Adenosine | A | Human | X-ray | 8CU6 | 8CU6_refined | 2.8 | A | Inactive | 1 | 72 | - | - | - | - | BRIL | - |
LJ-4517
|
small-molecule | Antagonist | adenosine | small-molecule | No | No | Shiriaeva A, Park D, Kim G, Lee Y, Hou X, Jarhad DB, Kim G, Yu J, Hyun YE, Kim W, Gao ZG, Jacobson KA, Han GW, Stevens RC, Jeong LS, Choi S, Cherezov V. | 10.1021/acs.jmedchem.2c00462 | 2022-08-31 | Yes | |
| AA2AR | A2A | Adenosine | A | Human | X-ray | 8CU7 | 8CU7_refined | 2.1 | A | Inactive | 1 | 72 | - | - | - | - | BRIL | - |
LJ-4517
|
small-molecule | Antagonist | adenosine | small-molecule | No | No | Shiriaeva A, Park D, Kim G, Lee Y, Hou X, Jarhad DB, Kim G, Yu J, Hyun YE, Kim W, Gao ZG, Jacobson KA, Han GW, Stevens RC, Jeong LS, Choi S, Cherezov V. | 10.1021/acs.jmedchem.2c00462 | 2022-08-31 | Yes | |
| SSR2 | SST2 | Somatostatin | A | Human | Cryo-EM | 7XAU | - | 3.0 | A | Active | 100 | 76 | Gi/o | αi1 | - | 63 | - | scFv16 |
Octreotide
|
peptide | Agonist | CST-17, SRIF-14, cortistatin-14, SRIF-28 | peptide | No | No | Bo Q, Yang F, Li Y, Meng X, Zhang H, Zhou Y, Ling S, Sun D, Lv P, Liu L, Shi P, Tian C | 10.1038/S41421-022-00405-2 | 2022-08-31 | Yes | |
| SSR2 | SST2 | Somatostatin | A | Human | Cryo-EM | 7XAV | 7XAV_refined | 2.9 | A | Active | 100 | 76 | Gi/o | αi1 | - | 63 | - | scFv16 |
lanreotide
|
peptide | Agonist | CST-17, SRIF-14, cortistatin-14, SRIF-28 | peptide | No | No | Bo Q, Yang F, Li Y, Meng X, Zhang H, Zhou Y, Ling S, Sun D, Lv P, Liu L, Shi P, Tian C | 10.1038/S41421-022-00405-2 | 2022-08-31 | Yes | |
| SSR2 | SST2 | Somatostatin | A | Human | Cryo-EM | 7XAT | 7XAT_refined | 2.9 | A | Active | 100 | 78 | Gi/o | αi1 | - | 63 | - | scFv16 |
SOMATOSTATIN
|
protein | Agonist | CST-17, SRIF-14, cortistatin-14, SRIF-28 | peptide | No | No | Bo Q, Yang F, Li Y, Meng X, Zhang H, Zhou Y, Ling S, Sun D, Lv P, Liu L, Shi P, Tian C | 10.1038/S41421-022-00405-2 | 2022-08-31 | Yes | |
| TRFR | TRH1 | Thyrotropin-releasing hormone | A | Human | Cryo-EM | 7X1T | - | 3.3 | A | Active | 100 | 68 | Gq/11 | αq | - | 57 | - | scFv16 |
taltirelin
|
small-molecule | Agonist | TRH | peptide | No | No | Yang F, Zhang H, Meng X, Li Y, Zhou Y, Ling S, Sun D, Lv P, Liu L, Shi P, Tian C | 10.1038/S41422-022-00646-6 | 2022-08-31 | Yes | |
| TRFR | TRH1 | Thyrotropin-releasing hormone | A | Human | Cryo-EM | 7X1U | 7X1U_refined | 3.2 | A | Active | 100 | 68 | Gq/11 | αq | - | 57 | - | scFv16 |
TRH
|
peptide | Agonist | TRH | peptide | No | No | - | - | 2022-08-31 | Yes | |
| 5HT2C | 5-HT2C | 5-Hydroxytryptamine | A | Human | Cryo-EM | 8DPH | - | 3.2 | A | Active | 100 | 58 | Gq/11 | αq | Gi2-mini-Gq chimera | 57 | - | scFv16 |
lorcaserin
|
small-molecule | Agonist | 5-hydroxytryptamine | small-molecule | No | No | Gumpper RH, Fay JF, Roth BL | 10.1016/J.CELREP.2022.111211 | 2022-08-24 | Yes | |
| 5HT2C | 5-HT2C | 5-Hydroxytryptamine | A | Human | Cryo-EM | 8DPG | - | 3.6 | A | Active | 100 | 58 | Gq/11 | αq | Gi2-mini-Gq chimera | 57 | - | scFv16 |
psilocin
|
small-molecule | Agonist | 5-hydroxytryptamine | small-molecule | No | No | Gumpper RH, Fay JF, Roth BL | 10.1016/J.CELREP.2022.111211 | 2022-08-24 | Yes | |
| 5HT2C | 5-HT2C | 5-Hydroxytryptamine | A | Human | Cryo-EM | 8DPF | - | 2.8 | A | Active | 100 | 58 | Gq/11 | αq | Gi2-mini-Gq chimera | 57 | - | scFv16 |
lorcaserin
|
small-molecule | Agonist | 5-hydroxytryptamine | small-molecule | No | No | Gumpper RH, Fay JF, Roth BL | 10.1016/J.CELREP.2022.111211 | 2022-08-24 | Yes | |
| 5HT2C | 5-HT2C | 5-Hydroxytryptamine | A | Human | Cryo-EM | 8DPI | - | 3.4 | A | Active | 100 | 58 | Gq/11 | αq | Gi2-mini-Gq chimera | 57 | - | scFv16 |
lorcaserin
|
small-molecule | Agonist | 5-hydroxytryptamine | small-molecule | No | No | Gumpper RH, Fay JF, Roth BL | 10.1016/J.CELREP.2022.111211 | 2022-08-24 | Yes | |
| AGRG2 | ADGRG2 | ADGRG | B2 | Mouse | Cryo-EM | 7YP7 | - | 3.1 | R | Active | 100 | 24 | Gs | αs | - | 59 | - | Nanobody-35 |
Apo (no ligand)
|
none | Apo (no ligand) | - | - | No | No | - | - | 2022-08-24 | Yes | |
| CCR2 | CCR2 | Chemokine | A | Human | Cryo-EM | 7XA3 | 7XA3_refined | 2.9 | R | Active | 100 | 79 | Gi/o | αi1 | - | 65 | - | scFv16 |
C-C motif chemokine 2
|
peptide | Agonist | CCL13, CCL11, CCL26, CCL8, CCL2, CCL7, CCL24, CCL16 | peptide | No | No | Shao Z, Tan Y, Shen Q, Hou L, Yao B, Qin J, Xu P, Mao C, Chen LN, Zhang H, Shen DD, Zhang C, Li W, Du X, Li F, Chen ZH, Jiang Y, Xu HE, Ying S, Ma H, Zhang Y, Shen H | 10.1038/S41421-022-00403-4 | 2022-08-24 | Yes | |
| CCR3 | CCR3 | Chemokine | A | Human | Cryo-EM | 7X9Y | 7X9Y_refined | 3.1 | R | Active | 100 | 83 | Gi/o | αi1 | - | 62 | - | scFv16 |
Apo (no ligand)
|
none | Apo (no ligand) | CXCL11, CCL13, CCL11, CCL26, CCL8, CXCL10, CCL2, CXCL9, CCL7, CCL28, CCL5, CCL24, CCL15 | peptide | No | No | Shao Z, Tan Y, Shen Q, Hou L, Yao B, Qin J, Xu P, Mao C, Chen LN, Zhang H, Shen DD, Zhang C, Li W, Du X, Li F, Chen ZH, Jiang Y, Xu HE, Ying S, Ma H, Zhang Y, Shen H | 10.1038/S41421-022-00403-4 | 2022-08-24 | Yes | |
| GP119 | GPR119 | GPR18, GPR55 and GPR119 | A | Human | Cryo-EM | 7XZ6 | - | 2.8 | R | Active | 100 | 87 | Gs | αs | - | 60 | BRIL | Nanobody-35 |
APD668
|
small-molecule | Agonist | N-oleoylethanolamide, N-palmitoylethanolamine, SEA, anandamide | small-molecule | No | No | Xu P, Huang S, Guo S, Yun Y, Cheng X, He X, Cai P, Lan Y, Zhou H, Jiang H, Jiang Y, Xie X, Xu HE | 10.1038/S41594-022-00816-5 | 2022-08-24 | Yes | |
| GP119 | GPR119 | GPR18, GPR55 and GPR119 | A | Human | Cryo-EM | 7XZ5 | - | 3.1 | R | Active | 100 | 87 | Gs | αs | - | 60 | BRIL | Nanobody-35 |
(4R,7R,18E)-4,7-dihydroxy-N,N,N-trimethyl-10-oxo-3,5,9-trioxa-4-phosphaheptacos-18-en-1-aminium 4-oxide
|
small-molecule | Agonist | N-oleoylethanolamide, N-palmitoylethanolamine, SEA, anandamide | small-molecule | No | No | Xu P, Huang S, Guo S, Yun Y, Cheng X, He X, Cai P, Lan Y, Zhou H, Jiang H, Jiang Y, Xie X, Xu HE | 10.1038/S41594-022-00816-5 | 2022-08-24 | Yes | |
| TSHR | TSH | Glycoprotein hormone | A | Human | Cryo-EM | 7XW5 | - | 3.0 | R | Active | 100 | 75 | Gs | αs | - | 60 | - | Nanobody-35 |
Thyrotropin subunit beta
Glycoprotein hormones alpha chain N-[4-[[5-[(2S)-3-benzyl-5-hydroxy-4-oxo-1,2-dihydroquinazolin-2-yl]-2-methoxyphenyl]methoxy]phenyl]acetamide |
protein protein small-molecule |
Agonist | TSH | peptide | No | No | Duan J, Xu P, Luan X, Ji Y, He X, Song N, Yuan Q, Jin Y, Cheng X, Jiang H, Zheng J, Zhang S, Jiang Y, Xu HE | 10.1038/S41586-022-05173-3 | 2022-08-24 | Yes | |
| PE2R3 | EP3 | Prostanoid | A | Human | Cryo-EM | 7WU9 | 7WU9_refined | 3.4 | R | Active | 100 | 70 | Gi/o | αi1 | - | 38 | - | scFv16 |
Apo (no ligand)
|
none | Apo (no ligand) | PGE1, PGF2α, PGI2, PGE2, thromboxane A2, PGD2 | small-molecule | No | No | Suno R, Sugita Y, Morimoto K, Takazaki H, Tsujimoto H, Hirose M, Suno-Ikeda C, Nomura N, Hino T, Inoue A, Iwasaki K, Kato T, Iwata S, Kobayashi T | 10.1016/J.CELREP.2022.111323 | 2022-08-17 | Yes | |
| TSHR | TSH | Glycoprotein hormone | A | Human | Cryo-EM | 7XW7 | 7XW7_refined | 5.5 | R | Inactive | 16 | 74 | - | - | - | - | - | - |
K1-70 scFv light chain
K1-70 scFv heavy chain |
protein protein |
Antagonist | TSH | peptide | No | No | Duan J, Xu P, Luan X, Ji Y, He X, Song N, Yuan Q, Jin Y, Cheng X, Jiang H, Zheng J, Zhang S, Jiang Y, Xu HE | 10.1038/S41586-022-05173-3 | 2022-08-17 | Yes | |
| TSHR | TSH | Glycoprotein hormone | A | Human | Cryo-EM | 7XW6 | - | 2.8 | R | Active | 100 | 74 | Gs | αs | - | 59 | - | Nanobody-35 |
M22 antibody heavy chain
M22 antibody light chain N-[4-[[5-[(2S)-3-benzyl-5-hydroxy-4-oxo-1,2-dihydroquinazolin-2-yl]-2-methoxyphenyl]methoxy]phenyl]acetamide |
protein protein small-molecule |
Agonist | TSH | peptide | No | No | Duan J, Xu P, Luan X, Ji Y, He X, Song N, Yuan Q, Jin Y, Cheng X, Jiang H, Zheng J, Zhang S, Jiang Y, Xu HE | 10.1038/S41586-022-05173-3 | 2022-08-17 | Yes | |
| AA2AR | A2A | Adenosine | A | Human | X-ray | 8DU3 | 8DU3_refined | 2.5 | A | Inactive | 1 | 72 | - | - | - | - | BRIL | - |
CHEMBL5206530
|
small-molecule | Antagonist | adenosine | small-molecule | No | No | Bolteau R, Duroux R, Laversin A, Vreulz B, Shiriaeva A, Stauch B, Han GW, Cherezov V, Renault N, Barczyk A, Ravez S, Coevoet M, Melnyk P, Liberelle M, Yous S. | 10.1016/j.ejmech.2022.114620 | 2022-08-10 | Yes | |
| AA2AR | A2A | Adenosine | A | Human | Cryo-EM | 7T32 | 7T32_refined | 3.4 | A | Inactive | 1 | 69 | - | - | - | - | BRIL | - |
ZM-241385
|
small-molecule | Antagonist | adenosine | small-molecule | No | No | Zhang K, Wu H, Hoppe N, Manglik A, Cheng Y | 10.1038/S41467-022-32125-2 | 2022-08-10 | Yes | |
| AGRG2 | ADGRG2 | ADGRG | B2 | Mouse | Cryo-EM | 7XKF | - | 2.4 | R | Active | 100 | 26 | Gs | αs | - | 57 | - | Nanobody-35 |
PRASTERONE
|
small-molecule | Agonist | - | - | No | No | Lin H, Xiao P, Bu RQ, Guo S, Yang Z, Yuan D, Zhu ZL, Zhang CX, He QT, Zhang C, Ping YQ, Zhao RJ, Ma CS, Liu CH, Zhang XN, Jiang D, Huang S, Xi YT, Zhang DL, Xue CY, Yang BS, Li JY, Lin HC, Zeng XH, Zhao H, Xu WM, Yi F, Liu Z, Sun JP, Yu X | 10.1038/S41589-022-01084-6 | 2022-08-10 | Yes | |
| AGRG2 | ADGRG2 | ADGRG | B2 | Mouse | Cryo-EM | 7XKE | - | 2.9 | R | Active | 100 | 25 | Gs | αs | Mini-Gs | 60 | - | Nanobody-35 |
PRASTERONE
|
small-molecule | Agonist | - | - | No | No | Lin H, Xiao P, Bu RQ, Guo S, Yang Z, Yuan D, Zhu ZL, Zhang CX, He QT, Zhang C, Ping YQ, Zhao RJ, Ma CS, Liu CH, Zhang XN, Jiang D, Huang S, Xi YT, Zhang DL, Xue CY, Yang BS, Li JY, Lin HC, Zeng XH, Zhao H, Xu WM, Yi F, Liu Z, Sun JP, Yu X | 10.1038/S41589-022-01084-6 | 2022-08-10 | Yes | |
| AGRG2 | ADGRG2 | ADGRG | B2 | Mouse | Cryo-EM | 7XKD | - | 2.4 | R | Active | 100 | 26 | Gs | αs | - | 57 | - | Nanobody-35 |
PRASTERONE
|
small-molecule | Agonist | - | - | No | No | Lin H, Xiao P, Bu RQ, Guo S, Yang Z, Yuan D, Zhu ZL, Zhang CX, He QT, Zhang C, Ping YQ, Zhao RJ, Ma CS, Liu CH, Zhang XN, Jiang D, Huang S, Xi YT, Zhang DL, Xue CY, Yang BS, Li JY, Lin HC, Zeng XH, Zhao H, Xu WM, Yi F, Liu Z, Sun JP, Yu X | 10.1038/S41589-022-01084-6 | 2022-08-10 | Yes | |
| OXYR | OT | Vasopressin and oxytocin | A | Human | Cryo-EM | 7QVM | - | 3.3 | R | Active | 100 | 64 | Gi/o | αo | - | 59 | - | scFv16 |
oxytocin
|
peptide | Agonist | oxytocin, vasopressin | peptide | No | No | Waltenspuhl Y, Ehrenmann J, Vacca S, Thom C, Medalia O, Pluckthun A | 10.1038/S41467-022-31325-0 | 2022-08-10 | Yes | |
| S1PR5 | S1P5 | Lysophospholipid (S1P) | A | Human | X-ray | 7YXA | 7YXA_refined | 2.2 | A | Inactive | 1 | 72 | - | - | - | - | BRIL | - |
4-[6-(2-naphthalen-1-ylethoxy)-2,3,4,5-tetrahydro-1H-3-benzazepin-3-ium-3-yl]butanoic acid
|
small-molecule | Antagonist | dihydrosphingosine 1-phosphate, sphingosylphosphorylcholine, sphingosine 1-phosphate | small-molecule | No | No | Lyapina E, Marin E, Gusach A, Orekhov P, Gerasimov A, Luginina A, Vakhrameev D, Ergasheva M, Kovaleva M, Khusainov G, Khorn P, Shevtsov M, Kovalev K, Bukhdruker S, Okhrimenko I, Popov P, Hu H, Weierstall U, Liu W, Cho Y, Gushchin I, Rogachev A, Bourenkov G, Park S, Park G, Hyun HJ, Park J, Gordeliy V, Borshchevskiy V, Mishin A, Cherezov V | 10.1038/S41467-022-32447-1 | 2022-08-10 | Yes | |
| TSHR | TSH | Glycoprotein hormone | A | Human | Cryo-EM | 7T9M | - | 3.1 | R | Inactive | 26 | 74 | - | - | - | - | - | - |
CS-17 light chain
CS-17 heavy chain |
protein protein |
Inverse agonist | TSH | peptide | No | No | Faust B, Billesbolle CB, Suomivuori CM, Singh I, Zhang K, Hoppe N, Pinto AFM, Diedrich JK, Muftuoglu Y, Szkudlinski MW, Saghatelian A, Dror RO, Cheng Y, Manglik A | 10.1038/S41586-022-05159-1 | 2022-08-10 | Yes | |
| PTH1R | PTH1 | Parathyroid hormone | B1 | Human | Cryo-EM | 7VVL | 7VVL_refined | 2.8 | R | Active | 100 | 58 | Gs | αs | - | 58 | - | Nanobody-35 |
teriparatide
|
peptide | Agonist | PTH, PTHrP, TIP39, PTHrP-(1-36) | peptide | No | No | Kobayashi K, Kawakami K, Kusakizako T, Miyauchi H, Tomita A, Kobayashi K, Shihoya W, Yamashita K, Nishizawa T, Kato HE, Inoue A, Nureki O | 10.1016/J.MOLCEL.2022.07.003 | 2022-08-03 | Yes | |
| PTH1R | PTH1 | Parathyroid hormone | B1 | Human | Cryo-EM | 7VVJ | 7VVJ_refined | 3.2 | R | Active | 100 | 62 | Gs | αs | - | 59 | - | Nanobody-35 |
PTHrP[1-36]
|
peptide | Agonist | PTH, PTHrP, TIP39, PTHrP-(1-36) | peptide | No | No | Kobayashi K, Kawakami K, Kusakizako T, Miyauchi H, Tomita A, Kobayashi K, Shihoya W, Yamashita K, Nishizawa T, Kato HE, Inoue A, Nureki O | 10.1016/J.MOLCEL.2022.07.003 | 2022-08-03 | Yes | |
| PTH1R | PTH1 | Parathyroid hormone | B1 | Human | Cryo-EM | 7VVO | 7VVO_refined | 4.1 | R | Active | 100 | 51 | Gs | αs | - | 58 | - | Nanobody-35 |
Parathyroid hormone
|
peptide | Agonist | PTH, PTHrP, TIP39, PTHrP-(1-36) | peptide | No | No | Kobayashi K, Kawakami K, Kusakizako T, Miyauchi H, Tomita A, Kobayashi K, Shihoya W, Yamashita K, Nishizawa T, Kato HE, Inoue A, Nureki O | 10.1016/J.MOLCEL.2022.07.003 | 2022-08-03 | Yes | |
| PTH1R | PTH1 | Parathyroid hormone | B1 | Human | Cryo-EM | 7VVM | 7VVM_refined | 3.2 | R | Active | 100 | 60 | Gs | αs | - | 58 | - | Nanobody-35 |
Parathyroid hormone
|
peptide | Agonist | PTH, PTHrP, TIP39, PTHrP-(1-36) | peptide | No | No | Kobayashi K, Kawakami K, Kusakizako T, Miyauchi H, Tomita A, Kobayashi K, Shihoya W, Yamashita K, Nishizawa T, Kato HE, Inoue A, Nureki O | 10.1016/J.MOLCEL.2022.07.003 | 2022-08-03 | Yes | |
| PTH1R | PTH1 | Parathyroid hormone | B1 | Human | Cryo-EM | 7VVK | - | 3.3 | R | Active | 100 | 56 | Gs | αs | - | 58 | - | Nanobody-35 |
teriparatide
|
peptide | Agonist | PTH, PTHrP, TIP39, PTHrP-(1-36) | peptide | No | No | Kobayashi K, Kawakami K, Kusakizako T, Miyauchi H, Tomita A, Kobayashi K, Shihoya W, Yamashita K, Nishizawa T, Kato HE, Inoue A, Nureki O | 10.1016/J.MOLCEL.2022.07.003 | 2022-08-03 | Yes | |
| PTH1R | PTH1 | Parathyroid hormone | B1 | Human | Cryo-EM | 7VVN | 7VVN_refined | 3.8 | R | Active | 100 | 51 | Gs | αs | - | 58 | - | Nanobody-35 |
teriparatide
|
peptide | Agonist | PTH, PTHrP, TIP39, PTHrP-(1-36) | peptide | No | No | Kobayashi K, Kawakami K, Kusakizako T, Miyauchi H, Tomita A, Kobayashi K, Shihoya W, Yamashita K, Nishizawa T, Kato HE, Inoue A, Nureki O | 10.1016/J.MOLCEL.2022.07.003 | 2022-08-03 | Yes | |
| SMO | SMO | Frizzled | F | Mouse | Cryo-EM | 8CXO | 8CXO_refined | 3.7 | A | Inactive | 14 | 43 | - | - | - | - | GlgA glycogen synthase | - |
Cholesterol
|
small-molecule | Agonist | - | - | No | No | Zhang K, Wu H, Hoppe N, Manglik A, Cheng Y | 10.1038/S41467-022-32125-2 | 2022-08-03 | Yes | |
| SSR2 | SST2 | Somatostatin | A | Human | X-ray | 7XNA | - | 2.7 | A | Inactive | 8 | 78 | - | - | - | - | - | - |
CYN 154806
|
peptide | Antagonist | CST-17, SRIF-14, cortistatin-14, SRIF-28 | peptide | No | No | Zhao W, Han S, Qiu N, Feng W, Lu M, Zhang W, Wang M, Zhou Q, Chen S, Xu W, Du J, Chu X, Yi C, Dai A, Hu L, Shen MY, Sun Y, Zhang Q, Ma Y, Zhong W, Yang D, Wang MW, Wu B, Zhao Q | 10.1038/S41422-022-00679-X | 2022-08-03 | Yes | |
| SSR2 | SST2 | Somatostatin | A | Human | X-ray | 7XN9 | 7XN9_refined | 2.6 | A | Inactive | 8 | 79 | - | - | - | - | - | - |
L-054,522
|
small-molecule | Agonist | CST-17, SRIF-14, cortistatin-14, SRIF-28 | peptide | No | No | Zhao W, Han S, Qiu N, Feng W, Lu M, Zhang W, Wang M, Zhou Q, Chen S, Xu W, Du J, Chu X, Yi C, Dai A, Hu L, Shen MY, Sun Y, Zhang Q, Ma Y, Zhong W, Yang D, Wang MW, Wu B, Zhao Q | 10.1038/S41422-022-00679-X | 2022-08-03 | Yes | |
| SSR2 | SST2 | Somatostatin | A | Human | Cryo-EM | 7XMR | 7XMR_refined | 3.1 | R | Active | 100 | 77 | Gi/o | αi1 | - | 63 | - | - |
SOMATOSTATIN
|
protein | Agonist | CST-17, SRIF-14, cortistatin-14, SRIF-28 | peptide | No | No | Zhao W, Han S, Qiu N, Feng W, Lu M, Zhang W, Wang M, Zhou Q, Chen S, Xu W, Du J, Chu X, Yi C, Dai A, Hu L, Shen MY, Sun Y, Zhang Q, Ma Y, Zhong W, Yang D, Wang MW, Wu B, Zhao Q | 10.1038/S41422-022-00679-X | 2022-08-03 | Yes | |
| SSR4 | SST4 | Somatostatin | A | Human | Cryo-EM | 7XMT | 7XMT_refined | 2.8 | R | Active | 100 | 68 | Gi/o | αi1 | - | 63 | - | scFv16 |
J-2156
|
small-molecule | Agonist | CST-17, SRIF-14, cortistatin-14, SRIF-28 | peptide | No | No | Zhao W, Han S, Qiu N, Feng W, Lu M, Zhang W, Wang M, Zhou Q, Chen S, Xu W, Du J, Chu X, Yi C, Dai A, Hu L, Shen MY, Sun Y, Zhang Q, Ma Y, Zhong W, Yang D, Wang MW, Wu B, Zhao Q | 10.1038/S41422-022-00679-X | 2022-08-03 | Yes | |
| SSR4 | SST4 | Somatostatin | A | Human | Cryo-EM | 7XMS | - | 2.9 | R | Active | 100 | 71 | Gi/o | αi1 | - | 63 | - | scFv16 |
SOMATOSTATIN
|
protein | Agonist | CST-17, SRIF-14, cortistatin-14, SRIF-28 | peptide | No | No | Zhao W, Han S, Qiu N, Feng W, Lu M, Zhang W, Wang M, Zhou Q, Chen S, Xu W, Du J, Chu X, Yi C, Dai A, Hu L, Shen MY, Sun Y, Zhang Q, Ma Y, Zhong W, Yang D, Wang MW, Wu B, Zhao Q | 10.1038/S41422-022-00679-X | 2022-08-03 | Yes | |
| TSHR | TSH | Glycoprotein hormone | A | Human | Cryo-EM | 7T9I | - | 2.9 | R | Active | 100 | 78 | Gs | αs | Mini-Gs | 56 | - | Nanobody-35 |
Thyrotropin subunit beta
Glycoprotein hormones alpha chain |
protein protein |
Agonist | TSH | peptide | No | No | Faust B, Billesbolle CB, Suomivuori CM, Singh I, Zhang K, Hoppe N, Pinto AFM, Diedrich JK, Muftuoglu Y, Szkudlinski MW, Saghatelian A, Dror RO, Cheng Y, Manglik A | 10.1038/S41586-022-05159-1 | 2022-08-03 | Yes | |
| TSHR | TSH | Glycoprotein hormone | A | Human | Cryo-EM | 7UTZ | - | 2.4 | R | Active | 100 | 79 | Gs | αs | Mini-Gs | 56 | - | Nanobody-35 |
Thyrotropin subunit beta
Glycoprotein hormones alpha chain analog TR1402 |
protein protein |
Agonist | TSH | peptide | No | No | Faust B, Billesbolle CB, Suomivuori CM, Singh I, Zhang K, Hoppe N, Pinto AFM, Diedrich JK, Muftuoglu Y, Szkudlinski MW, Saghatelian A, Dror RO, Cheng Y, Manglik A | 10.1038/S41586-022-05159-1 | 2022-08-03 | Yes | |
| TSHR | TSH | Glycoprotein hormone | A | Human | Cryo-EM | 7T9N | - | 2.9 | R | Active | 100 | 73 | Gs | αs | Mini-Gs | 56 | - | M22 Fab light chain M22 Fab heavy chain Nanobody-35 |
M22 antibody heavy chain
M22 antibody light chain |
protein protein |
Agonist | TSH | peptide | No | No | Faust B, Billesbolle CB, Suomivuori CM, Singh I, Zhang K, Hoppe N, Pinto AFM, Diedrich JK, Muftuoglu Y, Szkudlinski MW, Saghatelian A, Dror RO, Cheng Y, Manglik A | 10.1038/S41586-022-05159-1 | 2022-08-03 | Yes | |
| 5HT4R | 5-HT4 | 5-Hydroxytryptamine | A | Human | Cryo-EM | 7XT8 | - | 3.1 | R | Active | 100 | 76 | Gs | αs | - | 60 | BRIL | Nanobody-35 |
5-hydroxytryptamine
|
small-molecule | Agonist | 5-hydroxytryptamine | small-molecule | No | No | Huang S, Xu P, Shen DD, Simon IA, Mao C, Tan Y, Zhang H, Harpsoe K, Li H, Zhang Y, You C, Yu X, Jiang Y, Zhang Y, Gloriam DE, Xu HE | 10.1016/J.MOLCEL.2022.05.031 | 2022-07-27 | Yes | |
| 5HT4R | 5-HT4 | 5-Hydroxytryptamine | A | Human | Cryo-EM | 7XTA | 7XTA_refined | 3.2 | R | Active | 100 | 73 | Gi/o | αi1 | - | 62 | BRIL | scFv16 |
5-hydroxytryptamine
|
small-molecule | Agonist | 5-hydroxytryptamine | small-molecule | No | No | Huang S, Xu P, Shen DD, Simon IA, Mao C, Tan Y, Zhang H, Harpsoe K, Li H, Zhang Y, You C, Yu X, Jiang Y, Zhang Y, Gloriam DE, Xu HE | 10.1016/J.MOLCEL.2022.05.031 | 2022-07-27 | Yes | |
| 5HT4R | 5-HT4 | 5-Hydroxytryptamine | A | Human | Cryo-EM | 7XT9 | - | 3.2 | R | Active | 100 | 76 | Gs | αs | - | 60 | BRIL | - |
5-hydroxytryptamine
|
small-molecule | Agonist | 5-hydroxytryptamine | small-molecule | No | No | Huang S, Xu P, Shen DD, Simon IA, Mao C, Tan Y, Zhang H, Harpsoe K, Li H, Zhang Y, You C, Yu X, Jiang Y, Zhang Y, Gloriam DE, Xu HE | 10.1016/J.MOLCEL.2022.05.031 | 2022-07-27 | Yes | |
| 5HT6R | 5-HT6 | 5-Hydroxytryptamine | A | Human | Cryo-EM | 7XTB | 7XTB_refined | 3.3 | R | Active | 100 | 63 | Gs | αs | - | 60 | BRIL | Nanobody-35 |
5-hydroxytryptamine
|
small-molecule | Agonist | 5-hydroxytryptamine | small-molecule | No | No | Huang S, Xu P, Shen DD, Simon IA, Mao C, Tan Y, Zhang H, Harpsoe K, Li H, Zhang Y, You C, Yu X, Jiang Y, Zhang Y, Gloriam DE, Xu HE | 10.1016/J.MOLCEL.2022.05.031 | 2022-07-27 | Yes | |
| 5HT7R | 5-HT7 | 5-Hydroxytryptamine | A | Human | Cryo-EM | 7XTC | 7XTC_refined | 3.2 | R | Active | 100 | 57 | Gs | αs | - | 61 | BRIL | Nanobody-35 |
5-CT
|
small-molecule | Agonist | 5-hydroxytryptamine | small-molecule | No | No | Huang S, Xu P, Shen DD, Simon IA, Mao C, Tan Y, Zhang H, Harpsoe K, Li H, Zhang Y, You C, Yu X, Jiang Y, Zhang Y, Gloriam DE, Xu HE | 10.1016/J.MOLCEL.2022.05.031 | 2022-07-27 | Yes | |
| ACKR3 | ACKR3 | Chemokine | A | Human | Cryo-EM | 7SK8 | 7SK8_refined | 3.3 | A | Active | 96 | 85 | - | - | - | - | - | CID25 Fab light chain CID25 Fab heavy chain CID24 Fab light chain CID24 Fab heavy chain |
Stromal cell-derived factor 1
(1R)-4-[7-(3-carboxypropoxy)-6-methylquinolin-8-yl]-1-{[2-(4-hydroxypiperidin-1-yl)-1,3-thiazol-4-yl]methyl}-1,4-diazepan-1-ium |
peptide small-molecule |
Agonist Agonist (partial) |
CXCL11, CXCL12α | peptide | No | No | Yen YC, Schafer CT, Gustavsson M, Eberle SA, Dominik PK, Deneka D, Zhang P, Schall TJ, Kossiakoff AA, Tesmer JJG, Handel TM | 10.1126/SCIADV.ABN8063 | 2022-07-27 | Yes | |
| ACKR3 | ACKR3 | Chemokine | A | Human | Cryo-EM | 7SK4 | 7SK4_refined | 3.3 | A | Active | 96 | 84 | - | - | - | - | - | CID25 Fab light chain CID25 Fab heavy chain CID24 Fab light chain CID24 Fab heavy chain |
Stromal cell-derived factor 1
|
peptide | Agonist | CXCL11, CXCL12α | peptide | No | No | Yen YC, Schafer CT, Gustavsson M, Eberle SA, Dominik PK, Deneka D, Zhang P, Schall TJ, Kossiakoff AA, Tesmer JJG, Handel TM | 10.1126/SCIADV.ABN8063 | 2022-07-27 | Yes | |
| ACKR3 | ACKR3 | Chemokine | A | Human | Cryo-EM | 7SK3 | 7SK3_refined | 3.8 | A | Active | 96 | 84 | - | - | - | - | - | CID25 Fab light chain CID25 Fab heavy chain CID24 Fab light chain CID24 Fab heavy chain |
CXCL12α
|
peptide | Agonist | CXCL11, CXCL12α | peptide | No | No | Yen YC, Schafer CT, Gustavsson M, Eberle SA, Dominik PK, Deneka D, Zhang P, Schall TJ, Kossiakoff AA, Tesmer JJG, Handel TM | 10.1126/SCIADV.ABN8063 | 2022-07-27 | Yes | |
| ACKR3 | ACKR3 | Chemokine | A | Human | Cryo-EM | 7SK5 | 7SK5_refined | 4.0 | A | Active | 96 | 83 | - | - | - | - | - | CID24 Fab heavy chain CID24 Fab light chain anti-Fab Nanobody |
Stromal cell-derived factor 1
|
peptide | Agonist | CXCL11, CXCL12α | peptide | No | No | Yen YC, Schafer CT, Gustavsson M, Eberle SA, Dominik PK, Deneka D, Zhang P, Schall TJ, Kossiakoff AA, Tesmer JJG, Handel TM | 10.1126/SCIADV.ABN8063 | 2022-07-27 | Yes | |
| ACKR3 | ACKR3 | Chemokine | A | Human | Cryo-EM | 7SK9 | 7SK9_refined | 3.7 | A | Active | 96 | 78 | - | - | - | - | - | CID24 Fab heavy chain CID24 Fab light chain |
(1R)-4-[7-(3-carboxypropoxy)-6-methylquinolin-8-yl]-1-{[2-(4-hydroxypiperidin-1-yl)-1,3-thiazol-4-yl]methyl}-1,4-diazepan-1-ium
|
small-molecule | Agonist (partial) | CXCL11, CXCL12α | peptide | No | No | Yen YC, Schafer CT, Gustavsson M, Eberle SA, Dominik PK, Deneka D, Zhang P, Schall TJ, Kossiakoff AA, Tesmer JJG, Handel TM | 10.1126/SCIADV.ABN8063 | 2022-07-27 | Yes | |
| ACKR3 | ACKR3 | Chemokine | A | Human | Cryo-EM | 7SK7 | - | 3.3 | A | Active | 96 | 74 | - | - | - | - | - | CID25 Fab light chain CID25 Fab heavy chain anti-Fab Nanobody |
Stromal cell-derived factor 1
(1R)-4-[7-(3-carboxypropoxy)-6-methylquinolin-8-yl]-1-{[2-(4-hydroxypiperidin-1-yl)-1,3-thiazol-4-yl]methyl}-1,4-diazepan-1-ium |
peptide small-molecule |
Agonist Agonist (partial) |
CXCL11, CXCL12α | peptide | No | No | Yen YC, Schafer CT, Gustavsson M, Eberle SA, Dominik PK, Deneka D, Zhang P, Schall TJ, Kossiakoff AA, Tesmer JJG, Handel TM | 10.1126/SCIADV.ABN8063 | 2022-07-27 | Yes | |
| ACKR3 | ACKR3 | Chemokine | A | Human | Cryo-EM | 7SK6 | 7SK6_refined | 4.0 | A | Active | 96 | 83 | - | - | - | - | - | CID24 Fab light chain CID24 Fab heavy chain |
Stromal cell-derived factor 1
|
peptide | Agonist | CXCL11, CXCL12α | peptide | No | No | Yen YC, Schafer CT, Gustavsson M, Eberle SA, Dominik PK, Deneka D, Zhang P, Schall TJ, Kossiakoff AA, Tesmer JJG, Handel TM | 10.1126/SCIADV.ABN8063 | 2022-07-27 | Yes | |
| ADRB1 | β1 | Adrenoceptors | A | Wild turkey | Cryo-EM | 8DCS | - | 2.5 | R | Active | 100 | 57 | Gs | αs | - | 51 | T4-Lysozyme | Nanobody-35 |
Cyanopindolol
|
small-molecule | Antagonist | - | - | No | No | Su M, Paknejad N, Zhu L, Wang J, Do HN, Miao Y, Liu W, Hite RK, Huang XY | 10.1038/S41467-022-31823-1 | 2022-07-27 | Yes | |
| ADRB1 | β1 | Adrenoceptors | A | Wild turkey | Cryo-EM | 8DCR | - | 2.6 | R | Active | 100 | 57 | Gs | αs | - | 51 | T4-Lysozyme | Nanobody-35 |
Dobutamine
|
small-molecule | Agonist (partial) | - | - | No | No | Su M, Paknejad N, Zhu L, Wang J, Do HN, Miao Y, Liu W, Hite RK, Huang XY | 10.1038/S41467-022-31823-1 | 2022-07-27 | Yes | |
| APJ | apelin | Apelin | A | Human | Cryo-EM | 7W0O | 7W0O_refined | 3.8 | R | Active | 100 | 77 | Gi/o | αi1 | - | 64 | BRIL | scFv16 |
Apelin receptor early endogenous ligand
|
peptide | Agonist | apelin-13, apelin-36, apelin-17, Elabela/Toddler-21, Elabela/Toddler-32, Elabela/Toddler-11, apelin receptor early endogenous ligand, [Pyr1]apelin-13 | peptide | No | No | Yue Y, Liu L, Wu LJ, Wu Y, Wang L, Li F, Liu J, Han GW, Chen B, Lin X, Brouillette RL, Breault E, Longpre JM, Shi S, Lei H, Sarret P, Stevens RC, Hanson MA, Xu F | 10.1038/S41594-022-00797-5 | 2022-07-27 | Yes | |
| APJ | apelin | Apelin | A | Human | Cryo-EM | 7W0P | 7W0P_refined | 3.2 | R | Active | 100 | 77 | Gi/o | αi1 | - | 64 | BRIL | scFv16 |
Apelin receptor early endogenous ligand
|
peptide | Agonist | apelin-13, apelin-36, apelin-17, Elabela/Toddler-21, Elabela/Toddler-32, Elabela/Toddler-11, apelin receptor early endogenous ligand, [Pyr1]apelin-13 | peptide | No | No | Yue Y, Liu L, Wu LJ, Wu Y, Wang L, Li F, Liu J, Han GW, Chen B, Lin X, Brouillette RL, Breault E, Longpre JM, Shi S, Lei H, Sarret P, Stevens RC, Hanson MA, Xu F | 10.1038/S41594-022-00797-5 | 2022-07-27 | Yes | |
| APJ | apelin | Apelin | A | Human | Cryo-EM | 7W0N | - | 4.2 | R | Active | 100 | 78 | Gi/o | αi1 | - | 64 | BRIL | scFv16 |
Apelin receptor early endogenous ligand
|
peptide | Agonist | apelin-13, apelin-36, apelin-17, Elabela/Toddler-21, Elabela/Toddler-32, Elabela/Toddler-11, apelin receptor early endogenous ligand, [Pyr1]apelin-13 | peptide | No | No | Yue Y, Liu L, Wu LJ, Wu Y, Wang L, Li F, Liu J, Han GW, Chen B, Lin X, Brouillette RL, Breault E, Longpre JM, Shi S, Lei H, Sarret P, Stevens RC, Hanson MA, Xu F | 10.1038/S41594-022-00797-5 | 2022-07-27 | Yes | |
| APJ | apelin | Apelin | A | Human | Cryo-EM | 7W0L | 7W0L_refined | 3.6 | R | Active | 100 | 78 | Gi/o | αi1 | - | 64 | BRIL | scFv16 |
(1R,2S)-N-[4-(2,6-dimethoxyphenyl)-5-(6-methylpyridin-2-yl)-1,2,4-triazol-3-yl]-1-(5-methylpyrimidin-2-yl)-1-oxidanyl-propane-2-sulfonamide
|
small-molecule | Agonist | apelin-13, apelin-36, apelin-17, Elabela/Toddler-21, Elabela/Toddler-32, Elabela/Toddler-11, apelin receptor early endogenous ligand, [Pyr1]apelin-13 | peptide | No | No | Yue Y, Liu L, Wu LJ, Wu Y, Wang L, Li F, Liu J, Han GW, Chen B, Lin X, Brouillette RL, Breault E, Longpre JM, Shi S, Lei H, Sarret P, Stevens RC, Hanson MA, Xu F | 10.1038/S41594-022-00797-5 | 2022-07-27 | Yes | |
| APJ | apelin | Apelin | A | Human | Cryo-EM | 7W0M | 7W0M_refined | 3.7 | R | Active | 100 | 76 | Gi/o | αi1 | - | 62 | BRIL | scFv16 |
(1R,2S)-N-[4-(2,6-dimethoxyphenyl)-5-(6-methylpyridin-2-yl)-1,2,4-triazol-3-yl]-1-(5-methylpyrimidin-2-yl)-1-oxidanyl-propane-2-sulfonamide
|
small-molecule | Agonist | apelin-13, apelin-36, apelin-17, Elabela/Toddler-21, Elabela/Toddler-32, Elabela/Toddler-11, apelin receptor early endogenous ligand, [Pyr1]apelin-13 | peptide | No | No | Yue Y, Liu L, Wu LJ, Wu Y, Wang L, Li F, Liu J, Han GW, Chen B, Lin X, Brouillette RL, Breault E, Longpre JM, Shi S, Lei H, Sarret P, Stevens RC, Hanson MA, Xu F | 10.1038/S41594-022-00797-5 | 2022-07-27 | Yes | |
| APJ | apelin | Apelin | A | Human | X-ray | 7SUS | 7SUS_refined | 2.7 | A | Inactive | 8 | 76 | - | - | - | - | Rubredoxin | - |
(1R,2S)-N-[4-(2,6-dimethoxyphenyl)-5-(6-methylpyridin-2-yl)-1,2,4-triazol-3-yl]-1-(5-methylpyrimidin-2-yl)-1-oxidanyl-propane-2-sulfonamide
|
small-molecule | Agonist | apelin-13, apelin-36, apelin-17, Elabela/Toddler-21, Elabela/Toddler-32, Elabela/Toddler-11, apelin receptor early endogenous ligand, [Pyr1]apelin-13 | peptide | No | No | Yue Y, Liu L, Wu LJ, Wu Y, Wang L, Li F, Liu J, Han GW, Chen B, Lin X, Brouillette RL, Breault E, Longpre JM, Shi S, Lei H, Sarret P, Stevens RC, Hanson MA, Xu F | 10.1038/S41594-022-00797-5 | 2022-07-27 | Yes | |
| 5HT5A | 5-HT5A | 5-Hydroxytryptamine | A | Human | Cryo-EM | 7UM5 | 7UM5_refined | 2.7 | A | Active | 100 | 75 | Gi/o | αo | Mini-Go | 60 | - | scFv16 |
5-CT
|
small-molecule | Agonist | 5-hydroxytryptamine | small-molecule | No | No | Zhang S, Chen H, Zhang C, Yang Y, Popov P, Liu J, Krumm BE, Cao C, Kim K, Xiong Y, Katritch V, Shoichet BK, Jin J, Fay JF, Roth BL | 10.1038/S41594-022-00796-6 | 2022-07-20 | Yes | |
| 5HT5A | 5-HT5A | 5-Hydroxytryptamine | A | Human | X-ray | 7UM4 | 7UM4_refined | 2.8 | A | Inactive | 16 | 71 | - | - | - | - | PGS | - |
CHEMBL3654198
|
small-molecule | Antagonist | 5-hydroxytryptamine | small-molecule | No | No | Zhang S, Chen H, Zhang C, Yang Y, Popov P, Liu J, Krumm BE, Cao C, Kim K, Xiong Y, Katritch V, Shoichet BK, Jin J, Fay JF, Roth BL | 10.1038/S41594-022-00796-6 | 2022-07-20 | Yes | |
| 5HT5A | 5-HT5A | 5-Hydroxytryptamine | A | Human | Cryo-EM | 7UM6 | - | 2.8 | A | Active | 100 | 72 | Gi/o | αo | Mini-Go | 60 | - | scFv16 |
lisuride
|
small-molecule | Agonist | 5-hydroxytryptamine | small-molecule | No | No | Zhang S, Chen H, Zhang C, Yang Y, Popov P, Liu J, Krumm BE, Cao C, Kim K, Xiong Y, Katritch V, Shoichet BK, Jin J, Fay JF, Roth BL | 10.1038/S41594-022-00796-6 | 2022-07-20 | Yes | |
| 5HT5A | 5-HT5A | 5-Hydroxytryptamine | A | Human | Cryo-EM | 7UM7 | 7UM7_refined | 2.8 | A | Active | 100 | 72 | Gi/o | αo | Mini-Go | 60 | - | scFv16 |
methylergonovine
|
small-molecule | Agonist | 5-hydroxytryptamine | small-molecule | No | No | Zhang S, Chen H, Zhang C, Yang Y, Popov P, Liu J, Krumm BE, Cao C, Kim K, Xiong Y, Katritch V, Shoichet BK, Jin J, Fay JF, Roth BL | 10.1038/S41594-022-00796-6 | 2022-07-20 | Yes | |
| CCKAR | CCK1 | Cholecystokinin | A | Human | Cryo-EM | 7XOU | - | 3.2 | R | Active | 100 | 67 | Gs | αs | - | 58 | - | Nanobody-35 |
CCK-8
|
peptide | Agonist | CCK-39, gastrin-17, desulfated cholecystokinin-8, CCK-4, CCK-58, CCK-8, CCK-33 | peptide | No | No | Ding Y, Zhang H, Liao YY, Chen LN, Ji SY, Qin J, Mao C, Shen DD, Lin L, Wang H, Zhang Y, Li XM | 10.1038/S41421-022-00420-3 | 2022-07-20 | Yes | |
| CCKAR | CCK1 | Cholecystokinin | A | Human | Cryo-EM | 7XOV | - | 3.0 | R | Active | 100 | 67 | Gs | αs | - | 58 | - | Nanobody-35 |
SR146131
|
small-molecule | Agonist | CCK-39, gastrin-17, desulfated cholecystokinin-8, CCK-4, CCK-58, CCK-8, CCK-33 | peptide | No | No | Ding Y, Zhang H, Liao YY, Chen LN, Ji SY, Qin J, Mao C, Shen DD, Lin L, Wang H, Zhang Y, Li XM | 10.1038/S41421-022-00420-3 | 2022-07-20 | Yes | |
| GASR | CCK2 | Cholecystokinin | A | Human | Cryo-EM | 7XOX | 7XOX_refined | 3.1 | R | Active | 100 | 62 | Gq/11 | αq | - | 61 | - | scFv16 |
CCK-8
|
peptide | Agonist | CCK-39, desulfated gastrin-14, gastrin-71, desulfated gastrin-71, desulfated gastrin-17, gastrin-17, desulfated gastrin-34, desulfated cholecystokinin-8, gastrin-14, CCK-4, CCK-58, gastrin-34, CCK-8, CCK-33 | peptide | No | No | Ding Y, Zhang H, Liao YY, Chen LN, Ji SY, Qin J, Mao C, Shen DD, Lin L, Wang H, Zhang Y, Li XM | 10.1038/S41421-022-00420-3 | 2022-07-20 | Yes | |
| GASR | CCK2 | Cholecystokinin | A | Human | Cryo-EM | 7XOW | 7XOW_refined | 3.1 | R | Active | 100 | 62 | Gq/11 | αq | - | 61 | - | scFv16 |
desulfated gastrin-17
|
peptide | Agonist | CCK-39, desulfated gastrin-14, gastrin-71, desulfated gastrin-71, desulfated gastrin-17, gastrin-17, desulfated gastrin-34, desulfated cholecystokinin-8, gastrin-14, CCK-4, CCK-58, gastrin-34, CCK-8, CCK-33 | peptide | No | No | Ding Y, Zhang H, Liao YY, Chen LN, Ji SY, Qin J, Mao C, Shen DD, Lin L, Wang H, Zhang Y, Li XM | 10.1038/S41421-022-00420-3 | 2022-07-20 | Yes | |
| MRGRD | MRGPRD | A orphans | A | Human | Cryo-EM | 7Y15 | 7Y15_refined | 2.9 | R | Active | 100 | 82 | Gi/o | αi1 | - | 62 | BRIL | scFv16 |
Apo (no ligand)
|
none | Apo (no ligand) | β-alanine | small-molecule | No | No | Suzuki S, Iida M, Hiroaki Y, Tanaka K, Kawamoto A, Kato T, Oshima A | 10.1038/S42003-022-03668-3 | 2022-07-20 | Yes | |
| MRGRD | MRGPRD | A orphans | A | Human | Cryo-EM | 7Y14 | 7Y14_refined | 3.2 | R | Intermediate | 46 | 82 | - | - | - | - | BRIL | - |
β-alanine
|
small-molecule | Agonist | β-alanine | small-molecule | No | No | Suzuki S, Iida M, Hiroaki Y, Tanaka K, Kawamoto A, Kato T, Oshima A | 10.1038/S42003-022-03668-3 | 2022-07-20 | Yes | |
| MRGRD | MRGPRD | A orphans | A | Human | Cryo-EM | 7Y13 | 7Y13_refined | 3.1 | R | Intermediate | 46 | 82 | - | - | - | - | BRIL | - |
Apo (no ligand)
|
none | Apo (no ligand) | β-alanine | small-molecule | No | No | Suzuki S, Iida M, Hiroaki Y, Tanaka K, Kawamoto A, Kato T, Oshima A | 10.1038/S42003-022-03668-3 | 2022-07-20 | Yes | |
| MRGRD | MRGPRD | A orphans | A | Human | Cryo-EM | 7Y12 | - | 3.1 | R | Active | 100 | 82 | Gi/o | αi1 | - | 62 | BRIL | scFv16 |
β-alanine
|
small-molecule | Agonist | β-alanine | small-molecule | No | No | Suzuki S, Iida M, Hiroaki Y, Tanaka K, Kawamoto A, Kato T, Oshima A | 10.1038/S42003-022-03668-3 | 2022-07-20 | Yes | |
| CX3C1 | CX3CR1 | Chemokine | A | Human | Cryo-EM | 7XBW | 7XBW_refined | 2.8 | R | Active | 9 | 81 | Gi/o | αi1 | - | 61 | - | - |
Apo (no ligand)
|
none | Apo (no ligand) | CX3CL1 | peptide | No | No | Lu M, Zhao W, Han S, Lin X, Xu T, Tan Q, Wang M, Yi C, Chu X, Yang W, Zhu Y, Wu B, Zhao Q | 10.1126/SCIADV.ABN8048 | 2022-07-13 | Yes | |
| CX3C1 | CX3CR1 | Chemokine | A | Human | Cryo-EM | 7XBX | - | 3.4 | R | Active | 9 | 81 | Gi/o | αi1 | - | 61 | - | - |
CX3CL1
|
peptide | Agonist | CX3CL1 | peptide | No | No | - | - | 2022-07-13 | Yes | |
| GALR2 | GAL2 | Galanin | A | Human | Cryo-EM | 7XBD | 7XBD_refined | 3.1 | A | Active | 100 | 72 | Gq/11 | αq | - | 60 | - | scFv16 |
Galanin, Human
|
peptide | Agonist | galanin, spexin-1, galanin-like peptide | peptide | No | No | Heo Y, Ishimoto N, Jeon YE, Yun JH, Ohki M, Anraku Y, Sasaki M, Kita S, Fukuhara H, Ikuta T, Kawakami K, Inoue A, Maenaka K, Tame JRH, Lee W, Park SY | 10.1371/JOURNAL.PBIO.3001714 | 2022-07-13 | Yes | |
| SSR2 | SST2 | Somatostatin | A | Human | Cryo-EM | 7WJ5 | 7WJ5_refined | 3.7 | R | Active | 100 | 76 | Gi/o | αi1 | - | 60 | BRIL | scFv16 |
SOMATOSTATIN
|
protein | Agonist | CST-17, SRIF-14, cortistatin-14, SRIF-28 | peptide | No | No | Heo Y, Yoon E, Jeon YE, Yun JH, Ishimoto N, Woo H, Park SY, Song JJ, Lee W | 10.7554/ELIFE.76823 | 2022-07-13 | Yes | |
| 5HT2A | 5-HT2A | 5-Hydroxytryptamine | A | Human | Cryo-EM | 7RAN | - | 3.5 | A | Active | 100 | 57 | Gq/11 | αq | Gi2-mini-Gq chimera | 60 | - | scFv16 |
3-[(3R)-3-methyl-1,2,3,6-tetrahydropyridin-1-ium-5-yl]-1H-pyrrolo[2,3-b]pyridine
|
small-molecule | Agonist | tryptamine, 5-hydroxytryptamine | small-molecule | No | No | Kaplan AL, Confair DN, Kim K, Barros-Alvarez X, Rodriguiz RM, Yang Y, Kweon OS, Che T, McCorvy JD, Kamber DN, Phelan JP, Martins LC, Pogorelov VM, DiBerto JF, Slocum ST, Huang XP, Kumar JM, Robertson MJ, Panova O, Seven AB, Wetsel AQ, Wetsel WC, Irwin JJ, Skiniotis G, Shoichet BK, Roth BL, Ellman JA | 10.1038/S41586-022-05258-Z | 2022-07-06 | Yes | |
| GPBAR | GPBA | Bile acid | A | Human | Cryo-EM | 7XTQ | 7XTQ_refined | 3.2 | R | Active | 100 | 83 | Gs | αs | - | 58 | - | Nanobody-35 |
CHEMBL2181246
|
small-molecule | Agonist | lithocholic acid, deoxycholic acid, cholic acid, chenodeoxycholic acid | small-molecule | No | No | Ma L, Yang F, Wu X, Mao C, Guo L, Miao T, Zang SK, Jiang X, Shen DD, Wei T, Zhou H, Wei Q, Li S, Shu Q, Feng S, Jiang C, Chu B, Du L, Sun JP, Yu X, Zhang Y, Zhang P | 10.1073/PNAS.2117054119 | 2022-07-06 | Yes | |
| DRD1 | D1 | Dopamine | A | Human | Cryo-EM | 7X2C | 7X2C_refined | 3.2 | F | Active | 100 | 63 | Gs | αs | - | 58 | - | Nanobody-35 |
fenoldopam
|
small-molecule | Agonist | noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, dopamine, 5-hydroxytryptamine | small-molecule | No | No | Teng X, Chen S, Nie Y, Xiao P, Yu X, Shao Z, Zheng S | 10.1038/S41467-022-30929-W | 2022-06-29 | Yes | |
| GALR2 | GAL2 | Galanin | A | Human | Cryo-EM | 7XJK | 7XJK_refined | 3.3 | F | Active | 100 | 72 | Gq/11 | αq | - | 58 | - | scFv16 |
Galanin, Human
|
peptide | Agonist | galanin, spexin-1, galanin-like peptide | peptide | No | No | Jiang W, Zheng S | 10.1073/PNAS.2121465119 | 2022-06-29 | Yes | |
| GALR2 | GAL2 | Galanin | A | Human | Cryo-EM | 7XJL | 7XJL_refined | 3.5 | F | Active | 100 | 72 | Gq/11 | αq | - | 58 | - | scFv16 |
Spexin
|
small-molecule | Agonist | galanin, spexin-1, galanin-like peptide | peptide | No | No | Jiang W, Zheng S | 10.1073/PNAS.2121465119 | 2022-06-29 | Yes | |
| GLP1R | GLP-1 | Glucagon | B1 | Human | Cryo-EM | 7X8S | 7X8S_refined | 3.1 | R | Active | 100 | 65 | Gs | αs | - | 60 | - | Nanobody-35 |
WB4-24
|
small-molecule | Agonist | glucagon-like peptide 1-(7-36) amide, glucagon, glucagon-like peptide 1-(7-37) | peptide | No | No | Cong Z, Zhou Q, Li Y, Chen LN, Zhang ZC, Liang A, Liu Q, Wu X, Dai A, Xia T, Wu W, Zhang Y, Yang D, Wang MW | 10.1073/PNAS.2200155119 | 2022-06-29 | Yes | |
| GLP1R | GLP-1 | Glucagon | B1 | Human | Cryo-EM | 7X8R | - | 2.6 | R | Active | 100 | 64 | Gs | αs | - | 59 | - | Nanobody-35 |
CHEMBL2158411
|
small-molecule | Agonist | glucagon-like peptide 1-(7-36) amide, glucagon, glucagon-like peptide 1-(7-37) | peptide | No | No | Cong Z, Zhou Q, Li Y, Chen LN, Zhang ZC, Liang A, Liu Q, Wu X, Dai A, Xia T, Wu W, Zhang Y, Yang D, Wang MW | 10.1073/PNAS.2200155119 | 2022-06-29 | Yes | |
| HRH2 | H2 | Histamine | A | Human | Cryo-EM | 7UL3 | 7UL3_refined | 3.0 | A | Inactive | 8 | 75 | - | - | - | - | - | Nanobody-6M NabFab HC NabFab LC |
famotidine
|
small-molecule | Antagonist | histamine | small-molecule | No | No | Robertson MJ, Papasergi-Scott MM, He F, Seven AB, Meyerowitz JG, Panova O, Peroto MC, Che T, Skiniotis G | 10.1038/S41594-022-00859-8 | 2022-06-29 | Yes | |
| NTR1 | NTS1 | Neurotensin | A | Human | Cryo-EM | 7UL2 | 7UL2_refined | 2.4 | R | Inactive | 8 | 69 | - | - | - | - | - | Nanobody-6 |
meclinertant
|
small-molecule | Inverse agonist | large neurotensin, neurotensin, neuromedin N, large neuromedin N | peptide | No | No | Robertson MJ, Papasergi-Scott MM, He F, Seven AB, Meyerowitz JG, Panova O, Peroto MC, Che T, Skiniotis G | 10.1038/S41594-022-00859-8 | 2022-06-29 | Yes | |
| OPRM | μ | Opioid | A | Mouse | Cryo-EM | 7UL4 | 7UL4_refined | 2.8 | A | Inactive | 8 | 72 | - | - | - | - | - | Megabody-6 |
alvimopan
|
small-molecule | Antagonist | - | - | No | No | Robertson MJ, Papasergi-Scott MM, He F, Seven AB, Meyerowitz JG, Panova O, Peroto MC, Che T, Skiniotis G | 10.1038/S41594-022-00859-8 | 2022-06-29 | Yes | |
| SSR2 | SST2 | Somatostatin | A | Human | Cryo-EM | 7UL5 | 7UL5_refined | 3.1 | A | Inactive | 8 | 77 | - | - | - | - | - | Nanobody-6 |
Apo (no ligand)
|
none | Apo (no ligand) | CST-17, SRIF-14, cortistatin-14, SRIF-28 | peptide | No | No | Robertson MJ, Papasergi-Scott MM, He F, Seven AB, Meyerowitz JG, Panova O, Peroto MC, Che T, Skiniotis G | 10.1038/S41594-022-00859-8 | 2022-06-29 | Yes | |
| CNR1 | CB1 | Cannabinoid | A | Human | X-ray | 7FEE | 7FEE_refined | 2.7 | A | Inactive | 7 | 61 | - | - | - | - | GlgA glycogen synthase | - |
CP55940
6-methyl-3-[(1S)-2-nitro-1-thiophen-2-yl-ethyl]-2-phenyl-1H-indole |
small-molecule small-molecule |
Agonist PAM |
2-arachidonoylglycerol, anandamide | small-molecule | No | No | Yang X, Wang X, Xu Z, Wu C, Zhou Y, Wang Y, Lin G, Li K, Wu M, Xia A, Liu J, Cheng L, Zou J, Yan W, Shao Z, Yang S | 10.1038/S41589-022-01038-Y | 2022-06-15 | Yes | |
| CNR1 | CB1 | Cannabinoid | A | Human | Cryo-EM | 7WV9 | - | 3.4 | R | Active | 100 | 61 | Gi/o | αi2 | - | 63 | - | scFv16 |
CP55940
6-methyl-3-[(1S)-2-nitro-1-thiophen-2-yl-ethyl]-2-phenyl-1H-indole |
small-molecule small-molecule |
Agonist PAM |
2-arachidonoylglycerol, anandamide | small-molecule | No | No | Yang X, Wang X, Xu Z, Wu C, Zhou Y, Wang Y, Lin G, Li K, Wu M, Xia A, Liu J, Cheng L, Zou J, Yan W, Shao Z, Yang S | 10.1038/S41589-022-01038-Y | 2022-06-15 | Yes | |
| DRD1 | D1 | Dopamine | A | Human | Cryo-EM | 7F1O | - | 3.1 | F | Active | 100 | 62 | Gs | αs | - | 60 | - | Nanobody-35 |
dopamine
|
small-molecule | Agonist | noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, dopamine, 5-hydroxytryptamine | small-molecule | No | No | Teng X, Chen S, Wang Q, Chen Z, Wang X, Huang N, Zheng S | 10.1126/SCIADV.ABO4158 | 2022-06-15 | Yes | |
| DRD1 | D1 | Dopamine | A | Human | Cryo-EM | 7X2F | 7X2F_refined | 3.0 | F | Active | 100 | 63 | Gs | αs | - | 58 | - | Nanobody-35 |
dopamine
mevidalen |
small-molecule small-molecule |
Agonist PAM |
noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, dopamine, 5-hydroxytryptamine | small-molecule | No | No | Teng X, Chen S, Nie Y, Xiao P, Yu X, Shao Z, Zheng S | 10.1038/S41467-022-30929-W | 2022-06-15 | Yes | |
| DRD1 | D1 | Dopamine | A | Human | Cryo-EM | 7F24 | - | 4.2 | F | Active | 100 | 62 | Gs | αs | - | 57 | - | - |
dopamine
|
small-molecule | Agonist | noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, dopamine, 5-hydroxytryptamine | small-molecule | No | No | Teng X, Chen S, Wang Q, Chen Z, Wang X, Huang N, Zheng S | 10.1126/SCIADV.ABO4158 | 2022-06-15 | Yes | |
| DRD1 | D1 | Dopamine | A | Human | Cryo-EM | 7F0T | - | 3.1 | F | Active | 100 | 63 | Gs | αs | - | 58 | - | Nanobody-35 |
dopamine
|
small-molecule | Agonist | noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, dopamine, 5-hydroxytryptamine | small-molecule | No | No | Teng X, Chen S, Wang Q, Chen Z, Wang X, Huang N, Zheng S | 10.1126/SCIADV.ABO4158 | 2022-06-15 | Yes | |
| DRD1 | D1 | Dopamine | A | Human | Cryo-EM | 7F23 | - | 3.6 | F | Active | 100 | 62 | Gs | αs | - | 60 | - | Nanobody-35 |
dopamine
|
small-molecule | Agonist | noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, dopamine, 5-hydroxytryptamine | small-molecule | No | No | Teng X, Chen S, Wang Q, Chen Z, Wang X, Huang N, Zheng S | 10.1126/SCIADV.ABO4158 | 2022-06-15 | Yes | |
| DRD1 | D1 | Dopamine | A | Human | Cryo-EM | 7F1Z | - | 3.5 | F | Active | 100 | 62 | Gs | αs | - | 60 | - | - |
dopamine
|
small-molecule | Agonist | noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, dopamine, 5-hydroxytryptamine | small-molecule | No | No | Teng X, Chen S, Wang Q, Chen Z, Wang X, Huang N, Zheng S | 10.1126/SCIADV.ABO4158 | 2022-06-15 | Yes | |
| DRD1 | D1 | Dopamine | A | Human | Cryo-EM | 7X2D | 7X2D_refined | 3.3 | F | Active | 100 | 63 | Gs | αs | - | 58 | - | Nanobody-35 |
tavapadon
|
small-molecule | Agonist | noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, dopamine, 5-hydroxytryptamine | small-molecule | No | No | Teng X, Chen S, Nie Y, Xiao P, Yu X, Shao Z, Zheng S | 10.1038/S41467-022-30929-W | 2022-06-15 | Yes | |
| SMO | SMO | Frizzled | F | Human | X-ray | 7ZI0 | 7ZI0_refined | 3.0 | A | Inactive | 4 | 61 | - | - | - | - | BRIL | - |
3-chloro-N-[trans-4-(methylamino)cyclohexyl]-N-{[3-(pyridin-4-yl)phenyl]methyl}-1-benzothiophene-2-carboxamide
|
small-molecule | Antagonist | - | - | No | No | Kinnebrew M, Woolley RE, Ansell TB, Byrne EFX, Frigui S, Luchetti G, Sircar R, Nachtergaele S, Mydock-McGrane L, Krishnan K, Newstead S, Sansom MSP, Covey DF, Siebold C, Rohatgi R | 10.1126/SCIADV.ABM5563 | 2022-06-15 | Yes | |
| TRFR | TRH1 | Thyrotropin-releasing hormone | A | Human | Cryo-EM | 7WKD | - | 3.0 | R | Active | 100 | 66 | Gq/11 | αq | - | 60 | - | scFv16 |
TRH
|
peptide | Agonist | TRH | peptide | No | No | Xu Y, Cai H, You C, He X, Yuan Q, Jiang H, Cheng X, Jiang Y, Xu HE | 10.1038/S41422-022-00641-X | 2022-06-15 | Yes | |
| GLP1R | GLP-1 | Glucagon | B1 | Human | Cryo-EM | 7S15 | 7S15_refined | 3.8 | R | Active | 92 | 83 | - | - | - | - | - | - |
CHEMBL5191519
|
small-molecule | Agonist | glucagon-like peptide 1-(7-36) amide, glucagon, glucagon-like peptide 1-(7-37) | peptide | No | No | Griffith DA, Edmonds DJ, Fortin JP, Kalgutkar AS, Kuzmiski JB, Loria PM, Saxena AR, Bagley SW, Buckeridge C, Curto JM, Derksen DR, Dias JM, Griffor MC, Han S, Jackson VM, Landis MS, Lettiere D, Limberakis C, Liu Y, Mathiowetz AM, Patel JC, Piotrowski DW, Price DA, Ruggeri RB, Tess DA. | 10.1021/acs.jmedchem.1c01856 | 2022-06-08 | Yes | |
| OX2R | OX2 | Orexin | A | Human | Cryo-EM | 7SR8 | - | 3.3 | R | Active | 100 | 64 | Gq/11 | αq | - | 58 | - | scFv16 |
methyl (2R,3S)-3-[(methanesulfonyl)amino]-2-({[(1s,4S)-4-phenylcyclohexyl]oxy}methyl)piperidine-1-carboxylate
|
small-molecule | Agonist | orexin-B, orexin-A | peptide | No | No | Yin J, Kang Y, McGrath AP, Chapman K, Sjodt M, Kimura E, Okabe A, Koike T, Miyanohana Y, Shimizu Y, Rallabandi R, Lian P, Bai X, Flinspach M, De Brabander JK, Rosenbaum DM | 10.1038/S41467-022-30601-3 | 2022-06-08 | Yes | |
| SSR2 | SST2 | Somatostatin | A | Human | Cryo-EM | 7WIG | 7WIG_refined | 2.7 | R | Active | 100 | 77 | Gi/o | αi1 | - | 64 | - | scFv16 |
~{N}-[(2~{R})-1-[[(1~{R},3~{S})-3-(aminomethyl)cyclohexyl]methylamino]-3-(1~{H}-indol-3-yl)-1-oxidanylidene-propan-2-yl]spiro[indene-1,4'-piperidine]-1'-carboxamide
|
small-molecule | Agonist | CST-17, SRIF-14, cortistatin-14, SRIF-28 | peptide | No | No | Chen LN, Wang WW, Dong YJ, Shen DD, Guo J, Yu X, Qin J, Ji SY, Zhang H, Shen Q, He Q, Yang B, Zhang Y, Li Q, Mao C | 10.1038/S41422-022-00669-Z | 2022-06-01 | Yes | |
| SSR2 | SST2 | Somatostatin | A | Human | Cryo-EM | 7WIC | - | 2.8 | R | Active | 100 | 78 | Gi/o | αi1 | - | 64 | - | scFv16 |
SOMATOSTATIN
|
protein | Agonist | CST-17, SRIF-14, cortistatin-14, SRIF-28 | peptide | No | No | Chen LN, Wang WW, Dong YJ, Shen DD, Guo J, Yu X, Qin J, Ji SY, Zhang H, Shen Q, He Q, Yang B, Zhang Y, Li Q, Mao C | 10.1038/S41422-022-00669-Z | 2022-06-01 | Yes | |
| FPR1 | FPR1 | Formylpeptide | A | Human | Cryo-EM | 7EUO | 7EUO_refined | 2.9 | R | Active | 100 | 84 | Gi/o | αi1 | - | 62 | - | scFv16 |
Peptide Agonist fMLF
|
peptide | Agonist | fMet-Leu-Phe, cathepsin G, spinorphin, annexin I | peptide | No | No | Chen G, Wang X, Liao Q, Ge Y, Jiao H, Chen Q, Liu Y, Lyu W, Zhu L, van Zundert GCP, Robertson MJ, Skiniotis G, Du Y, Hu H, Ye RD | 10.1038/S41467-022-32822-Y | 2022-05-25 | Yes | |
| OX2R | OX2 | Orexin | A | Human | Cryo-EM | 7SQO | - | 3.2 | R | Active | 100 | 61 | Gi/o | αi1 | - | 61 | - | scFv16 |
methyl (2R,3S)-3-[(methanesulfonyl)amino]-2-({[(1s,4S)-4-phenylcyclohexyl]oxy}methyl)piperidine-1-carboxylate
|
small-molecule | Agonist | orexin-B, orexin-A | peptide | No | No | Yin J, Kang Y, McGrath AP, Chapman K, Sjodt M, Kimura E, Okabe A, Koike T, Miyanohana Y, Shimizu Y, Rallabandi R, Lian P, Bai X, Flinspach M, De Brabander JK, Rosenbaum DM | 10.1038/S41467-022-30601-3 | 2022-05-25 | Yes | |
| NPY1R | Y1 | Neuropeptide Y | A | Human | Cryo-EM | 7X9A | 7X9A_refined | 3.2 | R | Active | 100 | 80 | Gi/o | αi1 | - | 61 | - | - |
neuropeptide Y
|
peptide | Agonist | peptide YY, pancreatic polypeptide, neuropeptide Y | peptide | No | No | Tang T, Tan Q, Han S, Diemar A, Lobner K, Wang H, Schuss C, Behr V, Morl K, Wang M, Chu X, Yi C, Keller M, Kofoed J, Reedtz-Runge S, Kaiser A, Beck-Sickinger AG, Zhao Q, Wu B | 10.1126/SCIADV.ABM1232 | 2022-05-18 | Yes | |
| NPY2R | Y2 | Neuropeptide Y | A | Human | Cryo-EM | 7X9B | 7X9B_refined | 3.4 | R | Active | 100 | 79 | Gi/o | αi1 | - | 62 | - | - |
neuropeptide Y
|
peptide | Agonist | PYY-(3-36), peptide YY, neuropeptide Y-(3-36), pancreatic polypeptide, neuropeptide Y | peptide | No | No | Tang T, Tan Q, Han S, Diemar A, Lobner K, Wang H, Schuss C, Behr V, Morl K, Wang M, Chu X, Yi C, Keller M, Kofoed J, Reedtz-Runge S, Kaiser A, Beck-Sickinger AG, Zhao Q, Wu B | 10.1126/SCIADV.ABM1232 | 2022-05-18 | Yes | |
| NPY4R | Y4 | Neuropeptide Y | A | Human | Cryo-EM | 7X9C | 7X9C_refined | 3.0 | R | Active | 100 | 81 | Gi/o | αi1 | - | 61 | - | - |
Pancreatic polypeptide
|
peptide | Agonist | PYY-(3-36), peptide YY, pancreatic polypeptide, neuropeptide Y | peptide | No | No | Tang T, Tan Q, Han S, Diemar A, Lobner K, Wang H, Schuss C, Behr V, Morl K, Wang M, Chu X, Yi C, Keller M, Kofoed J, Reedtz-Runge S, Kaiser A, Beck-Sickinger AG, Zhao Q, Wu B | 10.1126/SCIADV.ABM1232 | 2022-05-18 | Yes | |
| VIPR2 | VPAC2 | VIP and PACAP | B1 | Human | Cryo-EM | 7VQX | - | 2.7 | R | Active | 100 | 82 | Gs | αs | - | 60 | - | Nanobody-35 |
PACAP-27
|
peptide | Agonist | secretin, PACAP-27, VIP, PACAP-38, PHI, GHRH | peptide | No | No | Xu Y, Feng W, Zhou Q, Liang A, Li J, Dai A, Zhao F, Yan J, Chen CW, Li H, Zhao LH, Xia T, Jiang Y, Xu HE, Yang D, Wang MW | 10.1038/S41467-022-30041-Z | 2022-05-18 | Yes | |
| VIPR2 | VPAC2 | VIP and PACAP | B1 | Human | Cryo-EM | 7WBJ | - | 3.4 | R | Active | 100 | 82 | Gs | αs | - | 60 | - | Nanobody-35 |
PACAP-27
|
peptide | Agonist | secretin, PACAP-27, VIP, PACAP-38, PHI, GHRH | peptide | No | No | Xu Y, Feng W, Zhou Q, Liang A, Li J, Dai A, Zhao F, Yan J, Chen CW, Li H, Zhao LH, Xia T, Jiang Y, Xu HE, Yang D, Wang MW | 10.1038/S41467-022-30041-Z | 2022-05-18 | Yes | |
| ACM4 | M4 | Acetylcholine (muscarinic) | A | Human | Cryo-EM | 7V69 | - | 3.4 | R | Active | 100 | 58 | Gi/o | αi1 | - | 62 | - | scFv16 |
Apo (no ligand)
|
none | Apo (no ligand) | acetylcholine | small-molecule | No | No | - | - | 2022-05-11 | Yes | |
| ACM4 | M4 | Acetylcholine (muscarinic) | A | Human | Cryo-EM | 7V6A | - | 3.6 | R | Active | 100 | 58 | Gi/o | αi1 | - | 62 | - | scFv16 |
methyl 4-[4-(3-methyl-2-oxidanylidene-benzimidazol-1-yl)piperidin-1-yl]piperidine-1-carboxylate
|
small-molecule | Allosteric agonist | acetylcholine | small-molecule | No | No | Wang J, Wu M, Chen Z, Wu L, Wang T, Cao D, Wang H, Liu S, Xu Y, Li F, Liu J, Chen N, Zhao S, Cheng J, Wang S, Hua T | 10.1038/S41467-022-30595-Y | 2022-05-11 | Yes | |
| ACM4 | M4 | Acetylcholine (muscarinic) | A | Human | Cryo-EM | 7V68 | - | 3.4 | R | Active | 100 | 58 | Gi/o | αi1 | - | 62 | - | scFv16 |
iperoxo
LY2119620 |
small-molecule small-molecule |
Agonist PAM |
acetylcholine | small-molecule | No | No | Wang J, Wu M, Chen Z, Wu L, Wang T, Cao D, Wang H, Liu S, Xu Y, Li F, Liu J, Chen N, Zhao S, Cheng J, Wang S, Hua T | 10.1038/S41467-022-30595-Y | 2022-05-11 | Yes | |
| AGRD1 | ADGRD1 | ADGRD | B2 | Human | Cryo-EM | 7EPT | - | 3.0 | R | Active | 100 | 31 | Gs | αs | - | 54 | - | Nanobody-35 |
Apo (no ligand)
|
none | Apo (no ligand) | - | - | No | No | Ping YQ, Xiao P, Yang F, Zhao RJ, Guo SC, Yan X, Wu X, Zhang C, Lu Y, Zhao F, Zhou F, Xi YT, Yin W, Liu FZ, He DF, Zhang DL, Zhu ZL, Jiang Y, Du L, Feng SQ, Schoneberg T, Liebscher I, Xu HE, Sun JP | 10.1038/S41586-022-04619-Y | 2022-05-11 | Yes | |
| AGRG5 | ADGRG5 | ADGRG | B2 | Human | Cryo-EM | 7EQ1 | - | 3.3 | R | Active | 100 | 54 | Gs | αs | - | 60 | - | scFv16 |
Apo (no ligand)
|
none | Apo (no ligand) | - | - | No | No | Ping YQ, Xiao P, Yang F, Zhao RJ, Guo SC, Yan X, Wu X, Zhang C, Lu Y, Zhao F, Zhou F, Xi YT, Yin W, Liu FZ, He DF, Zhang DL, Zhu ZL, Jiang Y, Du L, Feng SQ, Schoneberg T, Liebscher I, Xu HE, Sun JP | 10.1038/S41586-022-04619-Y | 2022-05-11 | Yes | |
| ADRB3 | β3 | Adrenoceptors | A | Dog | Cryo-EM | 7XJH | - | 3.3 | R | Active | 100 | 68 | Gs | αs | - | 59 | - | Nanobody-35 |
LEVISOPRENALINE
|
small-molecule | Agonist | - | - | No | No | Nagiri C, Kobayashi K, Tomita A, Kato M, Kobayashi K, Yamashita K, Nishizawa T, Inoue A, Shihoya W, Nureki O | 10.1016/J.MOLCEL.2021.06.024 | 2022-05-04 | Yes | |
| ADRB3 | β3 | Adrenoceptors | A | Dog | Cryo-EM | 7XJI | - | 3.9 | R | Active | 100 | 68 | Gs | αs | - | 59 | - | Nanobody-35 |
3-[3-[2-[[(2~{S})-2-(3-chlorophenyl)-2-oxidanyl-ethyl]amino]ethylamino]phenyl]benzoic acid
|
small-molecule | Agonist | - | - | No | No | Nureki I, Kobayashi K, Tanaka T, Demura K, Inoue A, Shihoya W, Nureki O | 10.1016/J.BBRC.2022.04.065 | 2022-05-04 | Yes | |
| OPRM | μ | Opioid | A | Mouse | Cryo-EM | 7U2L | - | 3.2 | D | Active | 100 | 71 | Gi/o | αi1 | - | 61 | - | scFv16 |
N-(5-carbamimidamidopentyl)-N-[1-(2-phenylethyl)piperidin-4-yl]propanamide
|
small-molecule | Agonist | - | - | No | No | Faouzi A, Wang H, Zaidi SA, DiBerto JF, Che T, Qu Q, Robertson MJ, Madasu MK, El Daibani A, Varga BR, Zhang T, Ruiz C, Liu S, Xu J, Appourchaux K, Slocum ST, Eans SO, Cameron MD, Al-Hasani R, Pan YX, Roth BL, McLaughlin JP, Skiniotis G, Katritch V, Kobilka BK, Majumdar S | 10.1038/S41586-022-05588-Y | 2022-05-04 | Yes | |
| AGRD1 | ADGRD1 | ADGRD | B2 | Human | Cryo-EM | 7WU2 | - | 2.8 | R | Active | 100 | 32 | Gs | αs | Mini-Gs | 53 | - | Nanobody-35 |
Apo (no ligand)
|
none | Apo (no ligand) | - | - | No | No | Qu X, Qiu N, Wang M, Zhang B, Du J, Zhong Z, Xu W, Chu X, Ma L, Yi C, Han S, Shui W, Zhao Q, Wu B | 10.1038/S41586-022-04580-W | 2022-04-27 | Yes | |
| AGRF1 | ADGRF1 | ADGRF | B2 | Human | Cryo-EM | 7WU3 | - | 3.1 | R | Active | 100 | 31 | Gs | αs | Mini-Gs | 54 | - | Nanobody-35 |
Apo (no ligand)
|
none | Apo (no ligand) | - | - | No | No | Qu X, Qiu N, Wang M, Zhang B, Du J, Zhong Z, Xu W, Chu X, Ma L, Yi C, Han S, Shui W, Zhao Q, Wu B | 10.1038/S41586-022-04580-W | 2022-04-27 | Yes | |
| AGRF1 | ADGRF1 | ADGRF | B2 | Human | Cryo-EM | 7WU4 | - | 3.4 | R | Active | 100 | 31 | Gi/o | αi1 | Mini-Gi1 | 58 | - | - |
Apo (no ligand)
|
none | Apo (no ligand) | - | - | No | No | Qu X, Qiu N, Wang M, Zhang B, Du J, Zhong Z, Xu W, Chu X, Ma L, Yi C, Han S, Shui W, Zhao Q, Wu B | 10.1038/S41586-022-04580-W | 2022-04-27 | Yes | |
| AGRF1 | ADGRF1 | ADGRF | B2 | Human | Cryo-EM | 7WU5 | - | 3.0 | R | Active | 100 | 31 | Gi/o | αi1 | Mini-Gi1 | 58 | - | - |
Apo (no ligand)
|
none | Apo (no ligand) | - | - | No | No | Qu X, Qiu N, Wang M, Zhang B, Du J, Zhong Z, Xu W, Chu X, Ma L, Yi C, Han S, Shui W, Zhao Q, Wu B | 10.1038/S41586-022-04580-W | 2022-04-27 | Yes | |
| AGRG1 | ADGRG1 | ADGRG | B2 | Human | Cryo-EM | 7SF8 | - | 2.7 | A | Active | 100 | 37 | G12/13 | α13 | Gi2-mini-G13 chimera | 56 | - | - |
Apo (no ligand)
|
none | Apo (no ligand) | - | - | No | No | Barros-Alvarez X, Nwokonko RM, Vizurraga A, Matzov D, He F, Papasergi-Scott MM, Robertson MJ, Panova O, Yardeni EH, Seven AB, Kwarcinski FE, Su H, Peroto MC, Meyerowitz JG, Shalev-Benami M, Tall GG, Skiniotis G | 10.1038/S41586-022-04575-7 | 2022-04-27 | Yes | |
| AGRG2 | ADGRG2 | ADGRG | B2 | Mouse | Cryo-EM | 7WUQ | - | 2.9 | R | Active | 100 | 28 | Gs | αs | - | 55 | - | Nanobody-35 |
Apo (no ligand)
|
none | Apo (no ligand) | - | - | No | No | Xiao P, Guo S, Wen X, He QT, Lin H, Huang SM, Gou L, Zhang C, Yang Z, Zhong YN, Yang CC, Li Y, Gong Z, Tao XN, Yang ZS, Lu Y, Li SL, He JY, Wang C, Zhang L, Kong L, Sun JP, Yu X | 10.1038/S41586-022-04590-8 | 2022-04-27 | Yes | |
| AGRG2 | ADGRG2 | ADGRG | B2 | Mouse | Cryo-EM | 7WUI | - | 3.1 | R | Active | 100 | 24 | Gs | αs | Mini-Gs | 58 | - | - |
IP15
|
peptide | Agonist | - | - | No | No | Xiao P, Guo S, Wen X, He QT, Lin H, Huang SM, Gou L, Zhang C, Yang Z, Zhong YN, Yang CC, Li Y, Gong Z, Tao XN, Yang ZS, Lu Y, Li SL, He JY, Wang C, Zhang L, Kong L, Sun JP, Yu X | 10.1038/S41586-022-04590-8 | 2022-04-27 | Yes | |
| AGRG4 | ADGRG4 | ADGRG | B2 | Human | Cryo-EM | 7WUJ | - | 3.3 | E | Active | 100 | 9 | Gs | αs | Mini-Gs | 59 | - | scFv16 Nanobody-35 |
Apo (no ligand)
|
none | Apo (no ligand) | - | - | No | No | Xiao P, Guo S, Wen X, He QT, Lin H, Huang SM, Gou L, Zhang C, Yang Z, Zhong YN, Yang CC, Li Y, Gong Z, Tao XN, Yang ZS, Lu Y, Li SL, He JY, Wang C, Zhang L, Kong L, Sun JP, Yu X | 10.1038/S41586-022-04590-8 | 2022-04-27 | Yes | |
| AGRL3 | ADGRL3 | ADGRL | B2 | Human | Cryo-EM | 7SF7 | - | 2.9 | A | Active | 100 | 19 | G12/13 | α13 | Gi2-mini-G13 chimera | 56 | - | - |
Apo (no ligand)
|
none | Apo (no ligand) | - | - | No | No | Barros-Alvarez X, Nwokonko RM, Vizurraga A, Matzov D, He F, Papasergi-Scott MM, Robertson MJ, Panova O, Yardeni EH, Seven AB, Kwarcinski FE, Su H, Peroto MC, Meyerowitz JG, Shalev-Benami M, Tall GG, Skiniotis G | 10.1038/S41586-022-04575-7 | 2022-04-27 | Yes | |
| GALR1 | GAL1 | Galanin | A | Human | Cryo-EM | 7WQ3 | 7WQ3_refined | 2.7 | R | Active | 100 | 83 | Gi/o | αi1 | - | 64 | - | scFv16 |
galanin
|
peptide | Agonist | galanin, galanin-like peptide | peptide | No | No | Duan J, Shen DD, Zhao T, Guo S, He X, Yin W, Xu P, Ji Y, Chen LN, Liu J, Zhang H, Liu Q, Shi Y, Cheng X, Jiang H, Eric Xu H, Zhang Y, Xie X, Jiang Y | 10.1038/S41467-022-29072-3 | 2022-04-20 | Yes | |
| GALR2 | GAL2 | Galanin | A | Human | Cryo-EM | 7WQ4 | 7WQ4_refined | 2.6 | R | Active | 100 | 73 | Gq/11 | αq | - | 60 | - | Nanobody-35 |
galanin
|
peptide | Agonist | galanin, spexin-1, galanin-like peptide | peptide | No | No | Duan J, Shen DD, Zhao T, Guo S, He X, Yin W, Xu P, Ji Y, Chen LN, Liu J, Zhang H, Liu Q, Shi Y, Cheng X, Jiang H, Eric Xu H, Zhang Y, Xie X, Jiang Y | 10.1038/S41467-022-29072-3 | 2022-04-20 | Yes | |
| NMUR1 | NMU1 | Neuromedin U | A | Human | Cryo-EM | 7W56 | - | 2.9 | R | Active | 100 | 65 | Gq/11 | αq | - | 59 | - | scFv16 |
Neuromedin-S
|
peptide | Agonist | neuromedin U-23, neuromedin S-33, neuromedin U-25, neuromedin S-36 | peptide | No | No | You C, Zhang Y, Xu P, Huang S, Yin W, Eric Xu H, Jiang Y | 10.1038/S41467-022-29683-W | 2022-04-20 | Yes | |
| NMUR1 | NMU1 | Neuromedin U | A | Human | Cryo-EM | 7W53 | - | 3.2 | R | Active | 100 | 62 | Gq/11 | αq | - | 54 | - | scFv16 |
Neuromedin U-25 (human)
|
peptide | Agonist | neuromedin U-23, neuromedin S-33, neuromedin U-25, neuromedin S-36 | peptide | No | No | You C, Zhang Y, Xu P, Huang S, Yin W, Eric Xu H, Jiang Y | 10.1038/S41467-022-29683-W | 2022-04-20 | Yes | |
| NMUR2 | NMU2 | Neuromedin U | A | Human | Cryo-EM | 7W57 | - | 3.2 | R | Active | 100 | 72 | Gq/11 | αq | - | 59 | - | scFv16 |
Neuromedin-S
|
peptide | Agonist | neuromedin U-23, neuromedin S-33, neuromedin U-25, neuromedin S-36 | peptide | No | No | You C, Zhang Y, Xu P, Huang S, Yin W, Eric Xu H, Jiang Y | 10.1038/S41467-022-29683-W | 2022-04-20 | Yes | |
| NMUR2 | NMU2 | Neuromedin U | A | Human | Cryo-EM | 7W55 | - | 2.8 | R | Active | 100 | 73 | Gq/11 | αq | - | 60 | - | scFv16 |
Neuromedin U-25 (human)
|
peptide | Agonist | neuromedin U-23, neuromedin S-33, neuromedin U-25, neuromedin S-36 | peptide | No | No | You C, Zhang Y, Xu P, Huang S, Yin W, Eric Xu H, Jiang Y | 10.1038/S41467-022-29683-W | 2022-04-20 | Yes | |
| OPRM | μ | Opioid | A | Mouse | Cryo-EM | 7SCG | - | 3.0 | D | Active | 100 | 71 | Gi/o | αi1 | - | 61 | - | scFv16 |
(2E)-N-[(2S)-2-(dimethylamino)-3-(4-hydroxyphenyl)propyl]-3-(naphthalen-1-yl)prop-2-enamide
|
small-molecule | Agonist | - | - | No | No | Wang H, Hetzer F, Huang W, Qu Q, Meyerowitz J, Kaindl J, Hubner H, Skiniotis G, Kobilka BK, Gmeiner P | 10.1002/ANIE.202200269 | 2022-04-20 | Yes | |
| OPRM | μ | Opioid | A | Mouse | Cryo-EM | 7SBF | - | 2.9 | R | Active | 100 | 71 | Gi/o | αi1 | - | 61 | BRIL | scFv16 |
N-[(2S)-2-(dimethylamino)-3-(4-hydroxyphenyl)propyl]-N'-[(2S)-1-(thiophen-3-yl)propan-2-yl]urea
|
small-molecule | Agonist | - | - | No | No | Wang H, Hetzer F, Huang W, Qu Q, Meyerowitz J, Kaindl J, Hubner H, Skiniotis G, Kobilka BK, Gmeiner P | 10.1002/ANIE.202200269 | 2022-04-20 | Yes | |
| AA2AR | A2A | Adenosine | A | Human | X-ray | 7EZC | 7EZC_refined | 3.8 | B | Active | 69 | 70 | - | - | - | - | BRIL | - |
UK-432,097
|
small-molecule | Agonist | adenosine | small-molecule | No | No | Cui M, Zhou Q, Xu Y, Weng Y, Yao D, Zhao S, Song G | 10.1107/S2052252522001907 | 2022-04-13 | Yes | |
| ADA2A | α2A | Adrenoceptors | A | Human | Cryo-EM | 7EJ0 | - | 3.2 | R | Active | 100 | 56 | Gi/o | αo | - | 61 | - | scFv16 |
(-)-noradrenaline
|
small-molecule | Agonist | (-)-adrenaline, (-)-noradrenaline | small-molecule | No | No | Xu J, Cao S, Hubner H, Weikert D, Chen G, Lu Q, Yuan D, Gmeiner P, Liu Z, Du Y | 10.1126/SCIADV.ABJ5347 | 2022-04-13 | Yes | |
| ADA2A | α2A | Adrenoceptors | A | Human | Cryo-EM | 7EJA | - | 3.6 | R | Active | 100 | 58 | Gi/o | αo | - | 59 | - | scFv16 |
dexmedetomidine
|
small-molecule | Agonist | (-)-adrenaline, (-)-noradrenaline | small-molecule | No | No | Xu J, Cao S, Hubner H, Weikert D, Chen G, Lu Q, Yuan D, Gmeiner P, Liu Z, Du Y | 10.1126/SCIADV.ABJ5347 | 2022-04-13 | Yes | |
| ADA2A | α2A | Adrenoceptors | A | Human | Cryo-EM | 7EJ8 | - | 3.0 | R | Active | 100 | 57 | Gi/o | αo | - | 61 | - | scFv16 |
brimonidine (UK14304)
|
small-molecule | Agonist | (-)-adrenaline, (-)-noradrenaline | small-molecule | No | No | Xu J, Cao S, Hubner H, Weikert D, Chen G, Lu Q, Yuan D, Gmeiner P, Liu Z, Du Y | 10.1126/SCIADV.ABJ5347 | 2022-04-13 | Yes | |
| ADA2A | α2A | Adrenoceptors | A | Human | Cryo-EM | 7EJK | - | 3.4 | R | Active | 100 | 55 | Gi/o | αo | - | 61 | - | scFv16 |
oxymetazoline
|
small-molecule | Agonist | (-)-adrenaline, (-)-noradrenaline | small-molecule | No | No | Xu J, Cao S, Hubner H, Weikert D, Chen G, Lu Q, Yuan D, Gmeiner P, Liu Z, Du Y | 10.1126/SCIADV.ABJ5347 | 2022-04-13 | Yes | |
| FPR1 | FPR1 | Formylpeptide | A | Human | Cryo-EM | 7WVU | 7WVU_refined | 3.3 | R | Active | 100 | 85 | Gi/o | αi1 | - | 62 | - | - |
FME-LEU-PHE
|
peptide | Agonist | fMet-Leu-Phe, cathepsin G, spinorphin, annexin I | peptide | No | No | Zhu Y, Lin X, Zong X, Han S, Wang M, Su Y, Ma L, Chu X, Yi C, Zhao Q, Wu B | 10.1038/S41467-022-29361-X | 2022-04-13 | Yes | |
| FPR2 | FPR2/ALX | Formylpeptide | A | Human | Cryo-EM | 7WVY | 7WVY_refined | 3.0 | R | Active | 100 | 85 | Gi/o | αi2 | - | 63 | BRIL | - |
Amyloid beta-Peptide (1-42)
|
peptide | Agonist | PrP106-126, aspirin triggered lipoxin A4, annexin I, LL-37, aspirin-triggered resolvin D1, serum amyloid A, resolvin D1, humanin, LXA4 | peptide | No | No | Zhu Y, Lin X, Zong X, Han S, Wang M, Su Y, Ma L, Chu X, Yi C, Zhao Q, Wu B | 10.1038/S41467-022-29361-X | 2022-04-13 | Yes | |
| FPR2 | FPR2/ALX | Formylpeptide | A | Human | Cryo-EM | 7WVW | - | 3.1 | R | Active | 100 | 85 | Gi/o | αi2 | - | 63 | BRIL | - |
FME-TYR-PHE-ILE-ASN-ILE-LEU-THE-LEU
|
peptide | Agonist | PrP106-126, aspirin triggered lipoxin A4, annexin I, LL-37, aspirin-triggered resolvin D1, serum amyloid A, resolvin D1, humanin, LXA4 | peptide | No | No | Zhu Y, Lin X, Zong X, Han S, Wang M, Su Y, Ma L, Chu X, Yi C, Zhao Q, Wu B | 10.1038/S41467-022-29361-X | 2022-04-13 | Yes | |
| FPR2 | FPR2/ALX | Formylpeptide | A | Human | Cryo-EM | 7WVX | - | 2.8 | R | Active | 100 | 85 | Gi/o | αi2 | - | 61 | BRIL | - |
humanin
|
peptide | Agonist | PrP106-126, aspirin triggered lipoxin A4, annexin I, LL-37, aspirin-triggered resolvin D1, serum amyloid A, resolvin D1, humanin, LXA4 | peptide | No | No | Zhu Y, Lin X, Zong X, Han S, Wang M, Su Y, Ma L, Chu X, Yi C, Zhao Q, Wu B | 10.1038/S41467-022-29361-X | 2022-04-13 | Yes | |
| FPR2 | FPR2/ALX | Formylpeptide | A | Human | Cryo-EM | 7WVV | 7WVV_refined | 2.9 | R | Active | 100 | 85 | Gi/o | αi2 | - | 63 | BRIL | - |
synthetic peptide
|
peptide | Agonist | PrP106-126, aspirin triggered lipoxin A4, annexin I, LL-37, aspirin-triggered resolvin D1, serum amyloid A, resolvin D1, humanin, LXA4 | peptide | No | No | Zhu Y, Lin X, Zong X, Han S, Wang M, Su Y, Ma L, Chu X, Yi C, Zhao Q, Wu B | 10.1038/S41467-022-29361-X | 2022-04-13 | Yes | |
| GIPR | GIP | Glucagon | B1 | Human | Cryo-EM | 7RBT | 7RBT_refined | 3.1 | R | Active | 100 | 81 | Gs | αs | - | 56 | - | scFv16 Nanobody-35 |
tirzepatide
2-fluoro-4-[(1R)-6-methoxy-1-methyl-2-{(1S)-1-[4-(propan-2-yl)phenyl]ethyl}-1,2,3,4-tetrahydroisoquinolin-5-yl]-6-[(2-methylpropyl)amino]phenol |
peptide small-molecule |
Agonist PAM |
gastric inhibitory polypeptide | peptide | No | No | Sun B, Willard FS, Feng D, Alsina-Fernandez J, Chen Q, Vieth M, Ho JD, Showalter AD, Stutsman C, Ding L, Suter TM, Dunbar JD, Carpenter JW, Mohammed FA, Aihara E, Brown RA, Bueno AB, Emmerson PJ, Moyers JS, Kobilka TS, Coghlan MP, Kobilka BK, Sloop KW | 10.1073/PNAS.2116506119 | 2022-04-13 | Yes | |
| GIPR | GIP | Glucagon | B1 | Human | Cryo-EM | 7RA3 | - | 3.2 | R | Active | 100 | 80 | Gs | αs | Engineered G alpha | 56 | - | scFv16 Nanobody-35 |
gastric inhibitory polypeptide (human) - Incretin
|
peptide | Agonist | gastric inhibitory polypeptide | peptide | No | No | Sun B, Willard FS, Feng D, Alsina-Fernandez J, Chen Q, Vieth M, Ho JD, Showalter AD, Stutsman C, Ding L, Suter TM, Dunbar JD, Carpenter JW, Mohammed FA, Aihara E, Brown RA, Bueno AB, Emmerson PJ, Moyers JS, Kobilka TS, Coghlan MP, Kobilka BK, Sloop KW | 10.1073/PNAS.2116506119 | 2022-04-13 | Yes | |
| GLP1R | GLP-1 | Glucagon | B1 | Human | Cryo-EM | 7RG9 | 7RG9_refined | 3.2 | R | Active | 100 | 58 | Gs | αs | - | 56 | - | scFv16 Nanobody-35 |
Apo (no ligand)
|
none | Apo (no ligand) | glucagon-like peptide 1-(7-36) amide, glucagon, glucagon-like peptide 1-(7-37) | peptide | No | No | Sun B, Willard FS, Feng D, Alsina-Fernandez J, Chen Q, Vieth M, Ho JD, Showalter AD, Stutsman C, Ding L, Suter TM, Dunbar JD, Carpenter JW, Mohammed FA, Aihara E, Brown RA, Bueno AB, Emmerson PJ, Moyers JS, Kobilka TS, Coghlan MP, Kobilka BK, Sloop KW | 10.1073/PNAS.2116506119 | 2022-04-13 | Yes | |
| GLP1R | GLP-1 | Glucagon | B1 | Human | Cryo-EM | 7RGP | - | 2.9 | R | Active | 100 | 82 | Gs | αs | Engineered G alpha | 55 | - | scFv16 Nanobody-35 |
tirzepatide
|
peptide | Agonist | glucagon-like peptide 1-(7-36) amide, glucagon, glucagon-like peptide 1-(7-37) | peptide | No | No | Sun B, Willard FS, Feng D, Alsina-Fernandez J, Chen Q, Vieth M, Ho JD, Showalter AD, Stutsman C, Ding L, Suter TM, Dunbar JD, Carpenter JW, Mohammed FA, Aihara E, Brown RA, Bueno AB, Emmerson PJ, Moyers JS, Kobilka TS, Coghlan MP, Kobilka BK, Sloop KW | 10.1073/PNAS.2116506119 | 2022-04-13 | Yes | |
| GP183 | GPR183 | A orphans | A | Human | Cryo-EM | 7TUY | 7TUY_refined | 3.0 | R | Active | 56 | 73 | - | - | - | - | BRIL | anti-BRIL Fab heavy chain anti-BRIL Fab light chain anti-Fab Nanobody |
8-[(2E)-3-(4-chlorophenyl)prop-2-enoyl]-3-[(3,4-dichlorophenyl)methyl]-1-oxa-3,8-diazaspiro[4.5]decan-2-one
|
small-molecule | Inverse agonist | 7β, 25-dihydroxycholesterol, 27-hydroxycholesterol, 7β, 27-dihydroxycholesterol, 7α,27-dihydroxycholesterol, 7β-hydroxycholesterol, 25-hydroxycholesterol, 7α,25-dihydroxycholesterol, 7α-hydroxycholesterol | small-molecule | No | No | Chen H, Huang W, Li X | 10.1016/J.STR.2022.04.006 | 2022-04-13 | Yes | |
| GP183 | GPR183 | A orphans | A | Human | Cryo-EM | 7TUZ | 7TUZ_refined | 3.1 | R | Active | 100 | 79 | Gi/o | αi1 | - | 64 | - | scFv16 |
(2S,4aS,4bS,7R,8S,8aS,9R,10aR)-7-[(2R,3R)-7-hydroxy-3,7-dimethyloctan-2-yl]-4a,7,8-trimethyltetradecahydrophenanthrene-2,9-diol
|
small-molecule | Agonist | 7β, 25-dihydroxycholesterol, 27-hydroxycholesterol, 7β, 27-dihydroxycholesterol, 7α,27-dihydroxycholesterol, 7β-hydroxycholesterol, 25-hydroxycholesterol, 7α,25-dihydroxycholesterol, 7α-hydroxycholesterol | small-molecule | No | No | Chen H, Huang W, Li X | 10.1016/J.STR.2022.04.006 | 2022-04-13 | Yes | |
| GPR88 | GPR88 | A orphans | A | Human | Cryo-EM | 7EJX | - | 2.4 | R | Active | 100 | 60 | Gi/o | αi1 | - | 61 | - | scFv16 |
compound 2 [PMID: 24793972]
|
small-molecule | Allosteric agonist | - | - | No | No | Chen G, Xu J, Inoue A, Schmidt MF, Bai C, Lu Q, Gmeiner P, Liu Z, Du Y | 10.1038/S41467-022-30081-5 | 2022-04-13 | Yes | |
| GHRHR | GHRH | Glucagon | B1 | Human | Cryo-EM | 7V9L | - | 2.6 | R | Active | 100 | 61 | Gs | αs | - | 60 | - | Nanobody-35 |
Apo (no ligand)
|
none | Apo (no ligand) | GHRH | peptide | No | No | Cong Z, Zhou F, Zhang C, Zou X, Zhang H, Wang Y, Zhou Q, Cai X, Liu Q, Li J, Shao L, Mao C, Wang X, Wu J, Xia T, Zhao LH, Jiang H, Zhang Y, Xu HE, Cheng X, Yang D, Wang MW | 10.1073/PNAS.2106606118 | 2022-04-06 | Yes | |
| GLP1R | GLP-1 | Glucagon | B1 | Human | Cryo-EM | 7VBH | 7VBH_refined | 3.0 | R | Active | 100 | 83 | Gs | αs | - | 53 | - | Nanobody-35 |
Peptide 20
|
peptide | Agonist | glucagon-like peptide 1-(7-36) amide, glucagon, glucagon-like peptide 1-(7-37) | peptide | No | No | Zhao F, Zhou Q, Cong Z, Hang K, Zou X, Zhang C, Chen Y, Dai A, Liang A, Ming Q, Wang M, Chen LN, Xu P, Chang R, Feng W, Xia T, Zhang Y, Wu B, Yang D, Zhao L, Xu HE, Wang MW | 10.1038/S41467-022-28683-0 | 2022-04-06 | Yes | |
| S1PR2 | S1P2 | Lysophospholipid (S1P) | A | Human | Cryo-EM | 7T6B | 7T6B_refined | 3.2 | R | Active | 100 | 75 | G12/13 | α13 | - | 60 | - | scFv16 |
sphingosine 1-phosphate
|
small-molecule | Agonist | dihydrosphingosine 1-phosphate, sphingosylphosphorylcholine, sphingosine 1-phosphate | small-molecule | No | No | Chen H, Chen K, Huang W, Staudt LM, Cyster JG, Li X | 10.1126/SCIADV.ABN0067 | 2022-04-06 | Yes | |
| CALCR | CT | Calcitonin | B1 | Human | Cryo-EM | 7TYX | - | 2.6 | R | Active | 100 | 77 | Gs | αs | - | 59 | - | Nanobody-35 |
Amylin rat
|
peptide | Agonist | adrenomedullin, calcitonin, β-CGRP, adrenomedullin 2/intermedin, α-CGRP, amylin | peptide | No | No | Cao J, Belousoff MJ, Liang YL, Johnson RM, Josephs TM, Fletcher MM, Christopoulos A, Hay DL, Danev R, Wootten D, Sexton PM | 10.1126/SCIENCE.ABM9609 | 2022-03-30 | Yes | |
| CALCR | CT | Calcitonin | B1 | Human | Cryo-EM | 7TYN | - | 2.6 | R | Active | 100 | 79 | Gs | αs | - | 58 | - | Nanobody-35 |
calcitonin (salmon synthetic)
|
small-molecule | Agonist | adrenomedullin, calcitonin, β-CGRP, adrenomedullin 2/intermedin, α-CGRP, amylin | peptide | No | No | Cao J, Belousoff MJ, Liang YL, Johnson RM, Josephs TM, Fletcher MM, Christopoulos A, Hay DL, Danev R, Wootten D, Sexton PM | 10.1126/SCIENCE.ABM9609 | 2022-03-30 | Yes | |
| CALCR | CT | Calcitonin | B1 | Human | Cryo-EM | 7TYI | - | 3.3 | R | Active | 100 | 77 | Gs | αs | - | 58 | - | Nanobody-35 |
Amylin rat
|
peptide | Agonist | adrenomedullin, calcitonin, β-CGRP, adrenomedullin 2/intermedin, α-CGRP, amylin | peptide | No | No | Cao J, Belousoff MJ, Liang YL, Johnson RM, Josephs TM, Fletcher MM, Christopoulos A, Hay DL, Danev R, Wootten D, Sexton PM | 10.1126/SCIENCE.ABM9609 | 2022-03-30 | Yes | |
| FPR1 | FPR1 | Formylpeptide | A | Human | Cryo-EM | 7T6T | 7T6T_refined | 3.2 | R | Active | 100 | 85 | Gi/o | αi1 | - | 61 | - | - |
synthetic peptide
|
peptide | Agonist | fMet-Leu-Phe, cathepsin G, spinorphin, annexin I | peptide | No | No | Zhuang Y, Wang L, Guo J, Sun D, Wang Y, Liu W, Xu HE, Zhang C | 10.1038/S41467-022-28586-0 | 2022-03-30 | Yes | |
| FPR2 | FPR2/ALX | Formylpeptide | A | Human | Cryo-EM | 7T6V | 7T6V_refined | 3.1 | R | Active | 100 | 85 | Gi/o | αi1 | - | 61 | - | scFv16 |
synthetic peptide
|
peptide | Agonist | PrP106-126, aspirin triggered lipoxin A4, annexin I, LL-37, aspirin-triggered resolvin D1, serum amyloid A, resolvin D1, humanin, LXA4 | peptide | No | No | Zhuang Y, Wang L, Guo J, Sun D, Wang Y, Liu W, Xu HE, Zhang C | 10.1038/S41467-022-28586-0 | 2022-03-30 | Yes | |
| FPR2 | FPR2/ALX | Formylpeptide | A | Human | Cryo-EM | 7T6S | 7T6S_refined | 3.0 | R | Active | 100 | 85 | Gi/o | αi1 | - | 61 | - | scFv16 |
N-(4-chlorophenyl)-N'-[1-methyl-3-oxo-2-phenyl-5-(propan-2-yl)-2,3-dihydro-1H-pyrazol-4-yl]urea
|
small-molecule | Agonist | PrP106-126, aspirin triggered lipoxin A4, annexin I, LL-37, aspirin-triggered resolvin D1, serum amyloid A, resolvin D1, humanin, LXA4 | peptide | No | No | - | - | 2022-03-30 | Yes | |
| FPR2 | FPR2/ALX | Formylpeptide | A | Human | Cryo-EM | 7T6U | - | 2.9 | R | Active | 100 | 85 | Gi/o | αi1 | - | 62 | - | - |
synthetic peptide
|
peptide | Agonist | PrP106-126, aspirin triggered lipoxin A4, annexin I, LL-37, aspirin-triggered resolvin D1, serum amyloid A, resolvin D1, humanin, LXA4 | peptide | No | No | Zhuang Y, Wang L, Guo J, Sun D, Wang Y, Liu W, Xu HE, Zhang C | 10.1038/S41467-022-28586-0 | 2022-03-30 | Yes | |
| CALCR | CT | Calcitonin | B1 | Human | Cryo-EM | 7TYF | - | 2.2 | R | Active | 100 | 77 | Gs | αs | - | 58 | - | Nanobody-35 RAMP1 |
amylin peptide
|
peptide | Agonist | adrenomedullin, calcitonin, β-CGRP, adrenomedullin 2/intermedin, α-CGRP, amylin | peptide | No | No | Cao J, Belousoff MJ, Liang YL, Johnson RM, Josephs TM, Fletcher MM, Christopoulos A, Hay DL, Danev R, Wootten D, Sexton PM | 10.1126/SCIENCE.ABM9609 | 2022-03-23 | Yes | |
| CALCR | CT | Calcitonin | B1 | Human | Cryo-EM | 7TZF | - | 2.4 | R | Active | 100 | 77 | Gs | αs | - | 59 | - | Nanobody-35 RAMP3 |
amylin peptide
|
peptide | Agonist | adrenomedullin, calcitonin, β-CGRP, adrenomedullin 2/intermedin, α-CGRP, amylin | peptide | No | No | Cao J, Belousoff MJ, Liang YL, Johnson RM, Josephs TM, Fletcher MM, Christopoulos A, Hay DL, Danev R, Wootten D, Sexton PM | 10.1126/SCIENCE.ABM9609 | 2022-03-23 | Yes | |
| CALCR | CT | Calcitonin | B1 | Human | Cryo-EM | 7TYH | - | 3.3 | R | Active | 100 | 78 | Gs | αs | - | 58 | - | Nanobody-35 |
Calcitonin human
|
peptide | Agonist | adrenomedullin, calcitonin, β-CGRP, adrenomedullin 2/intermedin, α-CGRP, amylin | peptide | No | No | Cao J, Belousoff MJ, Liang YL, Johnson RM, Josephs TM, Fletcher MM, Christopoulos A, Hay DL, Danev R, Wootten D, Sexton PM | 10.1126/SCIENCE.ABM9609 | 2022-03-23 | Yes | |
| CALCR | CT | Calcitonin | B1 | Human | Cryo-EM | 7TYO | - | 2.7 | R | Active | 100 | 76 | Gs | αs | - | 58 | - | Nanobody-35 |
Calcitonin human
|
peptide | Agonist | adrenomedullin, calcitonin, β-CGRP, adrenomedullin 2/intermedin, α-CGRP, amylin | peptide | No | No | Cao J, Belousoff MJ, Liang YL, Johnson RM, Josephs TM, Fletcher MM, Christopoulos A, Hay DL, Danev R, Wootten D, Sexton PM | 10.1126/SCIENCE.ABM9609 | 2022-03-23 | Yes | |
| CALCR | CT | Calcitonin | B1 | Human | Cryo-EM | 7TYY | - | 3.0 | R | Active | 100 | 78 | Gs | αs | - | 58 | - | Nanobody-35 |
calcitonin (salmon synthetic)
|
small-molecule | Agonist | adrenomedullin, calcitonin, β-CGRP, adrenomedullin 2/intermedin, α-CGRP, amylin | peptide | No | No | Cao J, Belousoff MJ, Liang YL, Johnson RM, Josephs TM, Fletcher MM, Christopoulos A, Hay DL, Danev R, Wootten D, Sexton PM | 10.1126/SCIENCE.ABM9609 | 2022-03-23 | Yes | |
| CALCR | CT | Calcitonin | B1 | Human | Cryo-EM | 7TYL | - | 3.3 | R | Active | 100 | 78 | Gs | αs | - | 58 | - | Nanobody-35 |
Amylin rat
|
peptide | Agonist | adrenomedullin, calcitonin, β-CGRP, adrenomedullin 2/intermedin, α-CGRP, amylin | peptide | No | No | Cao J, Belousoff MJ, Liang YL, Johnson RM, Josephs TM, Fletcher MM, Christopoulos A, Hay DL, Danev R, Wootten D, Sexton PM | 10.1126/SCIENCE.ABM9609 | 2022-03-23 | Yes | |
| CALCR | CT | Calcitonin | B1 | Human | Cryo-EM | 7TYW | - | 3.0 | R | Active | 100 | 78 | Gs | αs | - | 58 | - | Nanobody-35 |
calcitonin (salmon synthetic)
|
small-molecule | Agonist | adrenomedullin, calcitonin, β-CGRP, adrenomedullin 2/intermedin, α-CGRP, amylin | peptide | No | No | Cao J, Belousoff MJ, Liang YL, Johnson RM, Josephs TM, Fletcher MM, Christopoulos A, Hay DL, Danev R, Wootten D, Sexton PM | 10.1126/SCIENCE.ABM9609 | 2022-03-23 | Yes | |
| CCR1 | CCR1 | Chemokine | A | Human | Cryo-EM | 7VL8 | 7VL8_refined | 2.9 | R | Active | 100 | 80 | Gi/o | αi1 | - | 62 | - | scFv16 |
Apo (no ligand)
|
none | Apo (no ligand) | CCL13, CCL23, CCL8, CCL15, CCL7, CCL4, CCL14, CCL5, CCL3, CCL16 | peptide | No | No | Shao Z, Shen Q, Yao B, Mao C, Chen LN, Zhang H, Shen DD, Zhang C, Li W, Du X, Li F, Ma H, Chen ZH, Xu HE, Ying S, Zhang Y, Shen H | 10.1038/S41589-021-00918-Z | 2022-03-23 | Yes | |
| CCR1 | CCR1 | Chemokine | A | Human | Cryo-EM | 7VLA | 7VLA_refined | 2.7 | R | Active | 100 | 85 | Gi/o | αi1 | - | 64 | - | scFv16 |
CCL15(27-92)
|
peptide | Agonist | CCL13, CCL23, CCL8, CCL15, CCL7, CCL4, CCL14, CCL5, CCL3, CCL16 | peptide | No | No | Shao Z, Shen Q, Yao B, Mao C, Chen LN, Zhang H, Shen DD, Zhang C, Li W, Du X, Li F, Ma H, Chen ZH, Xu HE, Ying S, Zhang Y, Shen H | 10.1038/S41589-021-00918-Z | 2022-03-23 | Yes | |
| CCR1 | CCR1 | Chemokine | A | Human | Cryo-EM | 7VL9 | - | 2.6 | R | Active | 100 | 85 | Gi/o | αi1 | - | 62 | - | scFv16 |
CCL15(26-92)
|
peptide | Agonist | CCL13, CCL23, CCL8, CCL15, CCL7, CCL4, CCL14, CCL5, CCL3, CCL16 | peptide | No | No | Shao Z, Shen Q, Yao B, Mao C, Chen LN, Zhang H, Shen DD, Zhang C, Li W, Du X, Li F, Ma H, Chen ZH, Xu HE, Ying S, Zhang Y, Shen H | 10.1038/S41589-021-00918-Z | 2022-03-23 | Yes | |
| GRM3 | mGlu3 | Metabotropic glutamate | C | Human | Cryo-EM | 7WI6 | 7WI6_refined | 3.7 | A | Inactive | - | 82 | - | - | - | - | - | - |
LY341495
|
small-molecule | Antagonist | NAAG, L-glutamic acid | small-molecule | No | No | Fang W, Yang F, Xu C, Ling S, Lin L, Zhou Y, Sun W, Wang X, Liu P, Rondard P, Shi P, Pin JP, Tian C, Liu J | 10.1038/S41422-022-00623-Z | 2022-03-16 | Yes | |
| GRM3 | mGlu3 | Metabotropic glutamate | C | Human | Cryo-EM | 7WI8 | 7WI8_refined | 4.2 | A | Inactive | - | 82 | - | - | - | - | - | - |
LY341495
|
small-molecule | Antagonist | NAAG, L-glutamic acid | small-molecule | No | No | Fang W, Yang F, Xu C, Ling S, Lin L, Zhou Y, Sun W, Wang X, Liu P, Rondard P, Shi P, Pin JP, Tian C, Liu J | 10.1038/S41422-022-00623-Z | 2022-03-16 | Yes | |
| GRM3 | mGlu3 | Metabotropic glutamate | C | Human | Cryo-EM | 7WIH | 7WIH_refined | 3.7 | A | Active | - | 84 | - | - | - | - | - | - |
CHEMBL4081453
|
small-molecule | Agonist | NAAG, L-glutamic acid | small-molecule | No | No | Fang W, Yang F, Xu C, Ling S, Lin L, Zhou Y, Sun W, Wang X, Liu P, Rondard P, Shi P, Pin JP, Tian C, Liu J | 10.1038/S41422-022-00623-Z | 2022-03-16 | Yes | |
| LT4R1 | BLT1 | Leukotriene | A | Human | Cryo-EM | 7VKT | 7VKT_refined | 2.9 | A | Active | 100 | 82 | Gi/o | αi1 | - | 64 | - | scFv16 |
LTB4
|
small-molecule | Agonist | 12R-HETE, 20-hydroxy-LTB4, LTB4 | small-molecule | No | No | Wang N, He X, Zhao J, Jiang H, Cheng X, Xia Y, Eric Xu H, He Y | 10.1038/S41467-022-28820-9 | 2022-03-09 | Yes | |
| OXYR | OT | Vasopressin and oxytocin | A | Human | Cryo-EM | 7RYC | - | 2.9 | O | Active | 100 | 73 | Gq/11 | αq | Gamma subunit fused to alpha subunit | 55 | - | scFv16 |
oxytocin
|
peptide | Agonist | oxytocin, vasopressin | peptide | No | No | Meyerowitz JG, Robertson MJ, Barros-Alvarez X, Panova O, Nwokonko RM, Gao Y, Skiniotis G | 10.1038/S41594-022-00728-4 | 2022-03-09 | Yes | |
| SSR2 | SST2 | Somatostatin | A | Human | Cryo-EM | 7T11 | 7T11_refined | 2.7 | R | Active | 100 | 77 | Gi/o | αi3 | - | 62 | - | scFv16 |
Octreotide
|
peptide | Agonist | CST-17, SRIF-14, cortistatin-14, SRIF-28 | peptide | No | No | Robertson MJ, Meyerowitz JG, Panova O, Borrelli K, Skiniotis G | 10.1038/S41594-022-00727-5 | 2022-03-09 | Yes | |
| SSR2 | SST2 | Somatostatin | A | Human | Cryo-EM | 7T10 | - | 2.5 | R | Active | 100 | 78 | Gi/o | αi3 | - | 62 | - | scFv16 |
SOMATOSTATIN
|
protein | Agonist | CST-17, SRIF-14, cortistatin-14, SRIF-28 | peptide | No | No | Robertson MJ, Meyerowitz JG, Panova O, Borrelli K, Skiniotis G | 10.1038/S41594-022-00727-5 | 2022-03-09 | Yes | |
| AA2AR | A2A | Adenosine | A | Human | X-ray | 7PYR | 7PYR_refined | 2.6 | A | Inactive | 1 | 72 | - | - | - | - | BRIL | - |
Preladenant conjugate PSB-2115
|
small-molecule | Antagonist | adenosine | small-molecule | No | No | Claff T, Klapschinski TA, Tiruttani Subhramanyam UK, Vaassen VJ, Schlegel JG, Vielmuth C, Voss JH, Labahn J, Muller CE | 10.1002/ANIE.202115545 | 2022-03-02 | Yes | |
| AA2AR | A2A | Adenosine | A | Human | X-ray | 7PX4 | 7PX4_refined | 2.3 | A | Inactive | 1 | 72 | - | - | - | - | BRIL | - |
Preladenant conjugate PSB-2113
|
small-molecule | Antagonist | adenosine | small-molecule | No | No | Claff T, Klapschinski TA, Tiruttani Subhramanyam UK, Vaassen VJ, Schlegel JG, Vielmuth C, Voss JH, Labahn J, Muller CE | 10.1002/ANIE.202115545 | 2022-03-02 | Yes | |
| GIPR | GIP | Glucagon | B1 | Human | Cryo-EM | 7FIY | - | 3.4 | R | Active | 100 | 77 | Gs | αs | - | 60 | - | Nanobody-35 |
tirzepatide
|
peptide | Agonist | gastric inhibitory polypeptide | peptide | No | No | Zhao F, Zhou Q, Cong Z, Hang K, Zou X, Zhang C, Chen Y, Dai A, Liang A, Ming Q, Wang M, Chen LN, Xu P, Chang R, Feng W, Xia T, Zhang Y, Wu B, Yang D, Zhao L, Xu HE, Wang MW | 10.1038/S41467-022-28683-0 | 2022-03-02 | Yes | |
| GIPR | GIP | Glucagon | B1 | Human | Cryo-EM | 7VAB | 7VAB_refined | 3.2 | R | Active | 100 | 58 | Gs | αs | Mini-Gs | 60 | - | Nanobody-35 |
tirzepatide
|
peptide | Agonist | gastric inhibitory polypeptide | peptide | No | No | Zhao F, Zhou Q, Cong Z, Hang K, Zou X, Zhang C, Chen Y, Dai A, Liang A, Ming Q, Wang M, Chen LN, Xu P, Chang R, Feng W, Xia T, Zhang Y, Wu B, Yang D, Zhao L, Xu HE, Wang MW | 10.1038/S41467-022-28683-0 | 2022-03-02 | Yes | |
| GLP1R | GLP-1 | Glucagon | B1 | Human | Cryo-EM | 7VBI | - | 3.0 | R | Active | 100 | 83 | Gs | αs | Mini-Gs | 58 | - | - |
tirzepatide
|
peptide | Agonist | glucagon-like peptide 1-(7-36) amide, glucagon, glucagon-like peptide 1-(7-37) | peptide | No | No | Zhao F, Zhou Q, Cong Z, Hang K, Zou X, Zhang C, Chen Y, Dai A, Liang A, Ming Q, Wang M, Chen LN, Xu P, Chang R, Feng W, Xia T, Zhang Y, Wu B, Yang D, Zhao L, Xu HE, Wang MW | 10.1038/S41467-022-28683-0 | 2022-03-02 | Yes | |
| GLP1R | GLP-1 | Glucagon | B1 | Human | Cryo-EM | 7FIM | - | 3.4 | R | Active | 100 | 83 | Gs | αs | - | 57 | - | Nanobody-35 |
tirzepatide
|
peptide | Agonist | glucagon-like peptide 1-(7-36) amide, glucagon, glucagon-like peptide 1-(7-37) | peptide | No | No | Zhao F, Zhou Q, Cong Z, Hang K, Zou X, Zhang C, Chen Y, Dai A, Liang A, Ming Q, Wang M, Chen LN, Xu P, Chang R, Feng W, Xia T, Zhang Y, Wu B, Yang D, Zhao L, Xu HE, Wang MW | 10.1038/S41467-022-28683-0 | 2022-03-02 | Yes | |
| GLR | glucagon | Glucagon | B1 | Human | Cryo-EM | 7V35 | 7V35_refined | 3.4 | R | Active | 100 | 82 | Gs | αs | - | 53 | - | Nanobody-35 |
Peptide-20
|
peptide | Agonist | glucagon | peptide | No | No | Zhao F, Zhou Q, Cong Z, Hang K, Zou X, Zhang C, Chen Y, Dai A, Liang A, Ming Q, Wang M, Chen LN, Xu P, Chang R, Feng W, Xia T, Zhang Y, Wu B, Yang D, Zhao L, Xu HE, Wang MW | 10.1038/S41467-022-28683-0 | 2022-03-02 | Yes | |
| MTR1A | MT1 | Melatonin | A | Human | Cryo-EM | 7VGZ | 7VGZ_refined | 3.3 | B | Active | 100 | 81 | Gi/o | αi1 | - | 62 | - | scFv16 |
ramelteon
|
small-molecule | Agonist | melatonin | small-molecule | No | No | Wang Q, Lu Q, Guo Q, Teng M, Gong Q, Li X, Du Y, Liu Z, Tao Y | 10.1038/S41467-022-28111-3 | 2022-03-02 | Yes | |
| MTR1A | MT1 | Melatonin | A | Human | Cryo-EM | 7VGY | - | 3.1 | A | Active | 100 | 80 | Gi/o | αi1 | - | 62 | - | scFv16 |
2-iodo-melatonin
|
small-molecule | Agonist | melatonin | small-molecule | No | No | Wang Q, Lu Q, Guo Q, Teng M, Gong Q, Li X, Du Y, Liu Z, Tao Y | 10.1038/S41467-022-28111-3 | 2022-03-02 | Yes | |
| MTR1B | MT2 | Melatonin | A | Human | Cryo-EM | 7VH0 | 7VH0_refined | 3.5 | A | Active | 100 | 75 | Gi/o | αi1 | - | 61 | - | scFv16 |
ramelteon
|
small-molecule | Agonist | melatonin | small-molecule | No | No | Wang Q, Lu Q, Guo Q, Teng M, Gong Q, Li X, Du Y, Liu Z, Tao Y | 10.1038/S41467-022-28111-3 | 2022-03-02 | Yes | |
| GIPR | GIP | Glucagon | B1 | Human | Cryo-EM | 7FIN | - | 3.1 | R | Active | 100 | 82 | Gs | αs | - | 59 | - | Nanobody-35 |
Peptide-20
|
peptide | Agonist | gastric inhibitory polypeptide | peptide | No | No | Zhao F, Zhou Q, Cong Z, Hang K, Zou X, Zhang C, Chen Y, Dai A, Liang A, Ming Q, Wang M, Chen LN, Xu P, Chang R, Feng W, Xia T, Zhang Y, Wu B, Yang D, Zhao L, Xu HE, Wang MW | 10.1038/S41467-022-28683-0 | 2022-02-23 | Yes | |
| NPY1R | Y1 | Neuropeptide Y | A | Human | Cryo-EM | 7VGX | 7VGX_refined | 3.2 | R | Active | 100 | 73 | Gi/o | αi1 | - | 63 | - | scFv16 |
neuropeptide Y
|
peptide | Agonist | peptide YY, pancreatic polypeptide, neuropeptide Y | peptide | No | No | Park C, Kim J, Ko SB, Choi YK, Jeong H, Woo H, Kang H, Bang I, Kim SA, Yoon TY, Seok C, Im W, Choi HJ | 10.1038/S41467-022-28510-6 | 2022-02-23 | Yes | |
| AGTR2 | AT2 | Angiotensin | A | Human | X-ray | 7JNI | 7JNI_refined | 3.0 | A | Active | 98 | 82 | - | - | - | - | BRIL | - |
olodanrigan
|
small-molecule | Antagonist | angiotensin III, angiotensin-(1-7), angiotensin II | peptide | No | No | Perryman R, Renziehausen A, Shaye H, Kostagianni AD, Tsiailanis AD, Thorne T, Chatziathanasiadou MV, Sivolapenko GB, El Mubarak MA, Han GW, Zarzycka B, Katritch V, Lebon G, Lo Nigro C, Lattanzio L, Morse SV, Choi JJ, O'Neill K, Kanaki Z, Klinakis A, Crook T, Cherezov V, Tzakos AG, Syed N | 10.1073/PNAS.2116289119 | 2022-02-09 | Yes | |
| LPAR1 | LPA1 | Lysophospholipid (LPA) | A | Human | Cryo-EM | 7TD1 | - | 3.1 | R | Active | 100 | 80 | Gi/o | αi1 | - | 62 | - | - |
lysophosphatidic acid
|
small-molecule | Agonist | 1-O-Oleoyl-D-glycerol 3-phosphoric acid | small-molecule | No | No | Liu S, Paknejad N, Zhu L, Kihara Y, Ray M, Chun J, Liu W, Hite RK, Huang XY | 10.1038/S41467-022-28417-2 | 2022-02-09 | Yes | |
| LPAR1 | LPA1 | Lysophospholipid (LPA) | A | Human | Cryo-EM | 7TD2 | - | 3.1 | R | Active | 100 | 80 | Gi/o | αi1 | - | 62 | - | - |
lysophosphatidic acid
|
small-molecule | Agonist | 1-O-Oleoyl-D-glycerol 3-phosphoric acid | small-molecule | No | No | Liu S, Paknejad N, Zhu L, Kihara Y, Ray M, Chun J, Liu W, Hite RK, Huang XY | 10.1038/S41467-022-28417-2 | 2022-02-09 | Yes | |
| LPAR1 | LPA1 | Lysophospholipid (LPA) | A | Human | Cryo-EM | 7TD0 | - | 2.8 | R | Active | 100 | 80 | Gi/o | αi1 | - | 62 | - | - |
lysophosphatidic acid
|
small-molecule | Agonist | 1-O-Oleoyl-D-glycerol 3-phosphoric acid | small-molecule | No | No | Liu S, Paknejad N, Zhu L, Kihara Y, Ray M, Chun J, Liu W, Hite RK, Huang XY | 10.1038/S41467-022-28417-2 | 2022-02-09 | Yes | |
| S1PR1 | S1P1 | Lysophospholipid (S1P) | A | Human | Cryo-EM | 7TD4 | - | 2.6 | R | Active | 100 | 76 | Gi/o | αi1 | - | 63 | - | - |
siponimod
|
small-molecule | Agonist | dihydrosphingosine 1-phosphate, sphingosylphosphorylcholine, sphingosine 1-phosphate | small-molecule | No | No | Liu S, Paknejad N, Zhu L, Kihara Y, Ray M, Chun J, Liu W, Hite RK, Huang XY | 10.1038/S41467-022-28417-2 | 2022-02-09 | Yes | |
| S1PR1 | S1P1 | Lysophospholipid (S1P) | A | Human | Cryo-EM | 7TD3 | - | 3.0 | R | Active | 100 | 76 | Gi/o | αi1 | - | 63 | - | - |
sphingosine 1-phosphate
|
small-molecule | Agonist | dihydrosphingosine 1-phosphate, sphingosylphosphorylcholine, sphingosine 1-phosphate | small-molecule | No | No | Liu S, Paknejad N, Zhu L, Kihara Y, Ray M, Chun J, Liu W, Hite RK, Huang XY | 10.1038/S41467-022-28417-2 | 2022-02-09 | Yes | |
| 5HT2A | 5-HT2A | 5-Hydroxytryptamine | A | Human | X-ray | 7WC7 | 7WC7_refined | 2.6 | A | Inactive | 1 | 59 | - | - | - | - | BRIL | - |
lisuride
|
small-molecule | Agonist | tryptamine, 5-hydroxytryptamine | small-molecule | No | No | Cao D, Yu J, Wang H, Luo Z, Liu X, He L, Qi J, Fan L, Tang L, Chen Z, Li J, Cheng J, Wang S | 10.1126/SCIENCE.ABL8615 | 2022-01-26 | Yes | |
| 5HT2A | 5-HT2A | 5-Hydroxytryptamine | A | Human | X-ray | 7WC4 | 7WC4_refined | 3.2 | A | Inactive | 1 | 61 | - | - | - | - | BRIL | - |
5-hydroxytryptamine
|
small-molecule | Agonist | tryptamine, 5-hydroxytryptamine | small-molecule | No | No | Cao D, Yu J, Wang H, Luo Z, Liu X, He L, Qi J, Fan L, Tang L, Chen Z, Li J, Cheng J, Wang S | 10.1126/SCIENCE.ABL8615 | 2022-01-26 | Yes | |
| 5HT2A | 5-HT2A | 5-Hydroxytryptamine | A | Human | X-ray | 7WC5 | 7WC5_refined | 3.2 | A | Inactive | 1 | 60 | - | - | - | - | BRIL | - |
psilocin
|
small-molecule | Agonist | tryptamine, 5-hydroxytryptamine | small-molecule | No | No | Cao D, Yu J, Wang H, Luo Z, Liu X, He L, Qi J, Fan L, Tang L, Chen Z, Li J, Cheng J, Wang S | 10.1126/SCIENCE.ABL8615 | 2022-01-26 | Yes | |
| 5HT2A | 5-HT2A | 5-Hydroxytryptamine | A | Human | X-ray | 7WC8 | 7WC8_refined | 2.5 | A | Inactive | 1 | 59 | - | - | - | - | BRIL | - |
LUMATEPERONE
|
small-molecule | Agonist | tryptamine, 5-hydroxytryptamine | small-molecule | No | No | Cao D, Yu J, Wang H, Luo Z, Liu X, He L, Qi J, Fan L, Tang L, Chen Z, Li J, Cheng J, Wang S | 10.1126/SCIENCE.ABL8615 | 2022-01-26 | Yes | |
| 5HT2A | 5-HT2A | 5-Hydroxytryptamine | A | Human | X-ray | 7WC9 | 7WC9_refined | 2.5 | A | Inactive | 1 | 59 | - | - | - | - | BRIL | - |
IHCH-7086
|
small-molecule | Agonist | tryptamine, 5-hydroxytryptamine | small-molecule | No | No | Cao D, Yu J, Wang H, Luo Z, Liu X, He L, Qi J, Fan L, Tang L, Chen Z, Li J, Cheng J, Wang S | 10.1126/SCIENCE.ABL8615 | 2022-01-26 | Yes | |
| 5HT2A | 5-HT2A | 5-Hydroxytryptamine | A | Human | X-ray | 7WC6 | 7WC6_refined | 2.6 | A | Inactive | 1 | 58 | - | - | - | - | BRIL | - |
Lysergide
|
small-molecule | Agonist | tryptamine, 5-hydroxytryptamine | small-molecule | No | No | Cao D, Yu J, Wang H, Luo Z, Liu X, He L, Qi J, Fan L, Tang L, Chen Z, Li J, Cheng J, Wang S | 10.1126/SCIENCE.ABL8615 | 2022-01-26 | Yes | |
| US28 | US28 | Unclassified | A | strain AD169 | Cryo-EM | 7RKF | - | 4.0 | R | Active | 100 | 84 | Gq/11 | α11 | - | 97 | - | scFv16 |
Fractalkine
|
peptide | Agonist | - | - | No | No | Tsutsumi N, Maeda S, Qu Q, Vogele M, Jude KM, Suomivuori CM, Panova O, Waghray D, Kato HE, Velasco A, Dror RO, Skiniotis G, Kobilka BK, Garcia KC | 10.1126/SCIADV.ABL5442 | 2022-01-26 | Yes | |
| US28 | US28 | Unclassified | A | strain AD169 | Cryo-EM | 7RKN | - | 3.6 | R | Active | 100 | 83 | Gi/o | αi1 | - | 61 | - | scFv16 |
Fractalkine
|
peptide | Agonist | - | - | No | No | Tsutsumi N, Maeda S, Qu Q, Vogele M, Jude KM, Suomivuori CM, Panova O, Waghray D, Kato HE, Velasco A, Dror RO, Skiniotis G, Kobilka BK, Garcia KC | 10.1126/SCIADV.ABL5442 | 2022-01-26 | Yes | |
| US28 | US28 | Unclassified | A | strain AD169 | Cryo-EM | 7RKM | - | 3.5 | R | Active | 100 | 83 | Gi/o | αi1 | - | 61 | - | scFv16 |
Fractalkine
|
peptide | Agonist | - | - | No | No | Tsutsumi N, Maeda S, Qu Q, Vogele M, Jude KM, Suomivuori CM, Panova O, Waghray D, Kato HE, Velasco A, Dror RO, Skiniotis G, Kobilka BK, Garcia KC | 10.1126/SCIADV.ABL5442 | 2022-01-26 | Yes | |
| CASR | CaS | Calcium-sensing | C | Human | Cryo-EM | 7SIL | 7SIL_refined | 2.7 | A | Active | - | 72 | - | - | - | - | - | - |
Cyclomethyltryptophan
tecalcet |
small-molecule small-molecule |
Agonist | Mg2+, L-tryptophan, spermine, Ca2+ | small-molecule | No | No | Park J, Zuo H, Frangaj A, Fu Z, Yen LY, Zhang Z, Mosyak L, Slavkovich VN, Liu J, Ray KM, Cao B, Vallese F, Geng Y, Chen S, Grassucci R, Dandey VP, Tan YZ, Eng E, Lee Y, Kloss B, Liu Z, Hendrickson WA, Potter CS, Carragher B, Graziano J, Conigrave AD, Frank J, Clarke OB, Fan QR | 10.1073/PNAS.2115849118 | 2022-01-19 | Yes | |
| CASR | CaS | Calcium-sensing | C | Human | Cryo-EM | 7SIN | 7SIN_refined | 5.9 | A | Inactive | - | 74 | - | - | - | - | - | - |
NPS 2143
|
small-molecule | Antagonist | Mg2+, L-tryptophan, spermine, Ca2+ | small-molecule | No | No | Park J, Zuo H, Frangaj A, Fu Z, Yen LY, Zhang Z, Mosyak L, Slavkovich VN, Liu J, Ray KM, Cao B, Vallese F, Geng Y, Chen S, Grassucci R, Dandey VP, Tan YZ, Eng E, Lee Y, Kloss B, Liu Z, Hendrickson WA, Potter CS, Carragher B, Graziano J, Conigrave AD, Frank J, Clarke OB, Fan QR | 10.1073/PNAS.2115849118 | 2022-01-19 | Yes | |
| CASR | CaS | Calcium-sensing | C | Human | Cryo-EM | 7SIM | 7SIM_refined | 2.7 | A | Active | - | 72 | - | - | - | - | - | - |
Cyclomethyltryptophan
|
small-molecule | Agonist | Mg2+, L-tryptophan, spermine, Ca2+ | small-molecule | No | No | Park J, Zuo H, Frangaj A, Fu Z, Yen LY, Zhang Z, Mosyak L, Slavkovich VN, Liu J, Ray KM, Cao B, Vallese F, Geng Y, Chen S, Grassucci R, Dandey VP, Tan YZ, Eng E, Lee Y, Kloss B, Liu Z, Hendrickson WA, Potter CS, Carragher B, Graziano J, Conigrave AD, Frank J, Clarke OB, Fan QR | 10.1073/PNAS.2115849118 | 2022-01-19 | Yes | |
| GHSR | ghrelin | Ghrelin | A | Human | Cryo-EM | 7W2Z | 7W2Z_refined | 2.8 | R | Active | 100 | 82 | Gi/o | αo | - | 60 | - | scFv16 |
Ghrelin
|
peptide | Agonist | [des-Gln14]ghrelin, ghrelin | peptide | No | No | Qin J, Cai Y, Xu Z, Ming Q, Ji SY, Wu C, Zhang H, Mao C, Shen DD, Hirata K, Ma Y, Yan W, Zhang Y, Shao Z | 10.1038/S41467-022-27975-9 | 2022-01-19 | Yes | |
| GHSR | ghrelin | Ghrelin | A | Human | X-ray | 7F83 | 7F83_refined | 2.9 | A | Inactive | 14 | 78 | - | - | - | - | BRIL | - |
PF-05190457
|
small-molecule | Inverse agonist | [des-Gln14]ghrelin, ghrelin | peptide | No | No | Qin J, Cai Y, Xu Z, Ming Q, Ji SY, Wu C, Zhang H, Mao C, Shen DD, Hirata K, Ma Y, Yan W, Zhang Y, Shao Z | 10.1038/S41467-022-27975-9 | 2022-01-19 | Yes | |
| ADA1B | α1B | Adrenoceptors | A | Human | X-ray | 7B6W | - | 2.9 | A | Inactive | 1 | 51 | - | - | - | - | DARPin D12 | - |
(+)-cyclazosin
|
small-molecule | Inverse agonist | (-)-adrenaline, (-)-noradrenaline | small-molecule | No | No | Deluigi M, Morstein L, Schuster M, Klenk C, Merklinger L, Cridge RR, de Zhang LA, Klipp A, Vacca S, Vaid TM, Mittl PRE, Egloff P, Eberle SA, Zerbe O, Chalmers DK, Scott DJ, Pluckthun A | 10.1038/s41467-021-27911-3 | 2022-01-12 | Yes | |
| GLP1R | GLP-1 | Glucagon | B1 | Human | Cryo-EM | 7LLL | - | 3.7 | R | Active | 100 | 79 | Gs | αs | - | 59 | - | Nanobody-35 |
exendin-4
|
peptide | Agonist | glucagon-like peptide 1-(7-36) amide, glucagon, glucagon-like peptide 1-(7-37) | peptide | No | No | Deganutti G, Liang YL, Zhang X, Khoshouei M, Clydesdale L, Belousoff MJ, Venugopal H, Truong TT, Glukhova A, Keller AN, Gregory KJ, Leach K, Christopoulos A, Danev R, Reynolds CA, Zhao P, Sexton PM, Wootten D | 10.1038/S41467-021-27760-0 | 2022-01-12 | Yes | |
| GLP1R | GLP-1 | Glucagon | B1 | Human | Cryo-EM | 7LLY | 7LLY_refined | 3.3 | R | Active | 100 | 77 | Gs | αs | - | 50 | - | Nanobody-35 |
Pro-glucagon
|
peptide | Agonist | glucagon-like peptide 1-(7-36) amide, glucagon, glucagon-like peptide 1-(7-37) | peptide | No | No | Deganutti G, Liang YL, Zhang X, Khoshouei M, Clydesdale L, Belousoff MJ, Venugopal H, Truong TT, Glukhova A, Keller AN, Gregory KJ, Leach K, Christopoulos A, Danev R, Reynolds CA, Zhao P, Sexton PM, Wootten D | 10.1038/S41467-021-27760-0 | 2022-01-12 | Yes | |
| BKRB2 | B2 | Bradykinin | A | Human | Cryo-EM | 7F6I | 7F6I_refined | 2.8 | A | Active | 100 | 78 | Gq/11 | αq | - | 63 | - | - |
kallidin
|
peptide | Agonist | T-kinin, kallidin, Lys-[Hyp3]-bradykinin, bradykinin, [des-Arg10]kallidin, [Hyp3]bradykinin, [des-Arg9]bradykinin | peptide | No | No | Shen J, Zhang D, Fu Y, Chen A, Yang X, Zhang H | 10.1038/S41467-022-28399-1 | 2022-01-05 | Yes | |
| BKRB2 | B2 | Bradykinin | A | Human | Cryo-EM | 7F6H | 7F6H_refined | 2.9 | A | Active | 100 | 78 | Gq/11 | αq | - | 63 | - | - |
bradykinin
|
peptide | Agonist | T-kinin, kallidin, Lys-[Hyp3]-bradykinin, bradykinin, [des-Arg10]kallidin, [Hyp3]bradykinin, [des-Arg9]bradykinin | peptide | No | No | Shen J, Zhang D, Fu Y, Chen A, Yang X, Zhang H | 10.1038/S41467-022-28399-1 | 2022-01-05 | Yes | |
| GLP1R | GLP-1 | Glucagon | B1 | Human | Cryo-EM | 7S1M | 7S1M_refined | 2.4 | R | Active | 100 | 82 | Gs | αs | - | 59 | - | Nanobody-35 |
exendin-4
|
peptide | Agonist | glucagon-like peptide 1-(7-36) amide, glucagon, glucagon-like peptide 1-(7-37) | peptide | No | No | Cary BP, Deganutti G, Zhao P, Truong TT, Piper SJ, Liu X, Belousoff MJ, Danev R, Sexton PM, Wootten D, Gellman SH | 10.1038/S41589-021-00945-W | 2022-01-05 | Yes | |
| GLP1R | GLP-1 | Glucagon | B1 | Human | Cryo-EM | 7S3I | - | 2.5 | R | Active | 100 | 57 | Gs | αs | - | 59 | - | Nanobody-35 |
exendin-4
|
peptide | Agonist | glucagon-like peptide 1-(7-36) amide, glucagon, glucagon-like peptide 1-(7-37) | peptide | No | No | Cary BP, Deganutti G, Zhao P, Truong TT, Piper SJ, Liu X, Belousoff MJ, Danev R, Sexton PM, Wootten D, Gellman SH | 10.1038/S41589-021-00945-W | 2022-01-05 | Yes | |
| S1PR1 | S1P1 | Lysophospholipid (S1P) | A | Human | Cryo-EM | 7EO4 | 7EO4_refined | 2.9 | A | Active | 100 | 74 | Gi/o | αi1 | - | 43 | - | scFv16 |
siponimod
|
small-molecule | Agonist | dihydrosphingosine 1-phosphate, sphingosylphosphorylcholine, sphingosine 1-phosphate | small-molecule | No | No | Xu Z, Ikuta T, Kawakami K, Kise R, Qian Y, Xia R, Sun MX, Zhang A, Guo C, Cai XH, Huang Z, Inoue A, He Y | 10.1038/S41589-021-00930-3 | 2022-01-05 | Yes | |
| S1PR1 | S1P1 | Lysophospholipid (S1P) | A | Human | Cryo-EM | 7WF7 | 7WF7_refined | 3.4 | A | Active | 100 | 71 | Gi/o | αi1 | - | 40 | - | scFv16 |
sphingosine 1-phosphate
|
small-molecule | Agonist | dihydrosphingosine 1-phosphate, sphingosylphosphorylcholine, sphingosine 1-phosphate | small-molecule | No | No | Xu Z, Ikuta T, Kawakami K, Kise R, Qian Y, Xia R, Sun MX, Zhang A, Guo C, Cai XH, Huang Z, Inoue A, He Y | 10.1038/S41589-021-00930-3 | 2022-01-05 | Yes | |
| S1PR1 | S1P1 | Lysophospholipid (S1P) | A | Human | Cryo-EM | 7EO2 | 7EO2_refined | 2.9 | A | Active | 100 | 73 | Gi/o | αi1 | - | 62 | - | scFv16 |
(S)-FTY720-phosphate
|
small-molecule | Agonist | dihydrosphingosine 1-phosphate, sphingosylphosphorylcholine, sphingosine 1-phosphate | small-molecule | No | No | Xu Z, Ikuta T, Kawakami K, Kise R, Qian Y, Xia R, Sun MX, Zhang A, Guo C, Cai XH, Huang Z, Inoue A, He Y | 10.1038/S41589-021-00930-3 | 2022-01-05 | Yes | |
| CCKAR | CCK1 | Cholecystokinin | A | Human | X-ray | 7F8X | 7F8X_refined | 3.0 | A | Inactive | 1 | 66 | - | - | - | - | T4-Lysozyme | - |
NN9056
|
peptide | Agonist | CCK-39, gastrin-17, desulfated cholecystokinin-8, CCK-4, CCK-58, CCK-8, CCK-33 | peptide | No | No | Zhang X, He C, Wang M, Zhou Q, Yang D, Zhu Y, Feng W, Zhang H, Dai A, Chu X, Wang J, Yang Z, Jiang Y, Sensfuss U, Tan Q, Han S, Reedtz-Runge S, Xu HE, Zhao S, Wang MW, Wu B, Zhao Q | 10.1038/S41589-021-00866-8 | 2021-12-29 | Yes | |
| GP139 | GPR139 | A orphans | A | Human | Cryo-EM | 7VUH | 7VUH_refined | 3.2 | R | Active | 100 | 80 | Gs | αs | - | 61 | - | Nanobody-35 |
JNJ-63533054
|
small-molecule | Agonist | L-tryptophan, L-phenylalanine | small-molecule | No | No | - | - | 2021-12-29 | Yes | |
| GP139 | GPR139 | A orphans | A | Human | Cryo-EM | 7VUI | 7VUI_refined | 3.3 | R | Active | 100 | 79 | Gs | αs | - | 59 | - | Nanobody-35 |
JNJ-63533054
|
small-molecule | Agonist | L-tryptophan, L-phenylalanine | small-molecule | No | No | Zhou Y, Daver H, Trapkov B, Wu L, Wu M, Harpsoe K, Gentry PR, Liu K, Larionova M, Liu J, Chen N, Brauner-Osborne H, Gloriam DE, Hua T, Liu ZJ | 10.1038/S41422-021-00591-W | 2021-12-29 | Yes | |
| GP139 | GPR139 | A orphans | A | Human | Cryo-EM | 7VUG | 7VUG_refined | 3.2 | R | Active | 100 | 80 | Gi/o | αi1 | - | 62 | - | scFv16 |
JNJ-63533054
|
small-molecule | Agonist | L-tryptophan, L-phenylalanine | small-molecule | No | No | Zhou Y, Daver H, Trapkov B, Wu L, Wu M, Harpsoe K, Gentry PR, Liu K, Larionova M, Liu J, Chen N, Brauner-Osborne H, Gloriam DE, Hua T, Liu ZJ | 10.1038/S41422-021-00591-W | 2021-12-29 | Yes | |
| GP139 | GPR139 | A orphans | A | Human | Cryo-EM | 7VUJ | 7VUJ_refined | 3.8 | R | Active | 100 | 79 | Gs | αs | - | 59 | - | Nanobody-35 |
JNJ-63533054
|
small-molecule | Agonist | L-tryptophan, L-phenylalanine | small-molecule | No | No | Zhou Y, Daver H, Trapkov B, Wu L, Wu M, Harpsoe K, Gentry PR, Liu K, Larionova M, Liu J, Chen N, Brauner-Osborne H, Gloriam DE, Hua T, Liu ZJ | 10.1038/S41422-021-00591-W | 2021-12-29 | Yes | |
| 5HT2A | 5-HT2A | 5-Hydroxytryptamine | A | Human | X-ray | 7VOD | 7VOD_refined | 3.3 | A | Inactive | 1 | 58 | - | - | - | - | BRIL | - |
cariprazine
|
small-molecule | Agonist (partial) | tryptamine, 5-hydroxytryptamine | small-molecule | No | No | Chen Z, Fan L, Wang H, Yu J, Lu D, Qi J, Nie F, Luo Z, Liu Z, Cheng J, Wang S | 10.1038/S41593-021-00971-W | 2021-12-22 | Yes | |
| 5HT2A | 5-HT2A | 5-Hydroxytryptamine | A | Human | X-ray | 7VOE | 7VOE_refined | 2.9 | A | Inactive | 1 | 58 | - | - | - | - | BRIL | - |
aripiprazole
|
small-molecule | Agonist (partial) | tryptamine, 5-hydroxytryptamine | small-molecule | No | No | Chen Z, Fan L, Wang H, Yu J, Lu D, Qi J, Nie F, Luo Z, Liu Z, Cheng J, Wang S | 10.1038/S41593-021-00971-W | 2021-12-22 | Yes | |
| GHSR | ghrelin | Ghrelin | A | Human | Cryo-EM | 7NA8 | - | 2.7 | R | Active | 100 | 78 | Gi/o | αi1 | - | 61 | - | Antibody fragment |
ibutamoren
|
small-molecule | Agonist | [des-Gln14]ghrelin, ghrelin | peptide | No | No | Liu H, Sun D, Myasnikov A, Damian M, Baneres JL, Sun J, Zhang C | 10.1038/S41467-021-26735-5 | 2021-12-15 | Yes | |
| GHSR | ghrelin | Ghrelin | A | Human | Cryo-EM | 7NA7 | 7NA7_refined | 2.7 | R | Active | 100 | 80 | Gi/o | αi1 | - | 61 | - | Antibody fragment |
Ghrelin-27
|
peptide | Agonist | [des-Gln14]ghrelin, ghrelin | peptide | No | No | Liu H, Sun D, Myasnikov A, Damian M, Baneres JL, Sun J, Zhang C | 10.1038/S41467-021-26735-5 | 2021-12-15 | Yes | |
| NK1R | NK1 | Tachykinin | A | Human | Cryo-EM | 7P02 | - | 2.9 | R | Active | 100 | 71 | Gs | αs | Gs-Gi1 chimera | 57 | - | scFv16 |
substance P
|
peptide | Agonist | neurokinin A, neuropeptide K, hemokinin 1, neurokinin B, neuropeptide-γ, substance P | peptide | No | No | Thom C, Ehrenmann J, Vacca S, Waltenspuhl Y, Schoppe J, Medalia O, Pluckthun A | 10.1126/SCIADV.ABK2872 | 2021-12-15 | Yes | |
| NK1R | NK1 | Tachykinin | A | Human | Cryo-EM | 7P00 | - | 2.7 | R | Active | 100 | 71 | Gq/11 | αq | Gq-Gs-Gi1 chimera | 59 | - | scFv16 |
substance P
|
peptide | Agonist | neurokinin A, neuropeptide K, hemokinin 1, neurokinin B, neuropeptide-γ, substance P | peptide | No | No | Thom C, Ehrenmann J, Vacca S, Waltenspuhl Y, Schoppe J, Medalia O, Pluckthun A | 10.1126/SCIADV.ABK2872 | 2021-12-15 | Yes | |
| GP158 | GPR158 | C Orphans | C | Human | Cryo-EM | 7EWP | 7EWP_refined | 4.3 | A | Inactive | - | 47 | - | - | - | - | - | - |
Apo (no ligand)
|
none | Apo (no ligand) | - | - | No | No | Jeong E, Kim Y, Jeong J, Cho Y | 10.1038/S41467-021-27147-1 | 2021-12-01 | Yes | |
| GP158 | GPR158 | C Orphans | C | Human | Cryo-EM | 7EWR | 7EWR_refined | 4.7 | A | Inactive | - | 47 | - | - | - | - | - | - |
Apo (no ligand)
|
none | Apo (no ligand) | - | - | No | No | Jeong E, Kim Y, Jeong J, Cho Y | 10.1038/S41467-021-27147-1 | 2021-12-01 | Yes | |
| GP158 | GPR158 | C Orphans | C | Human | Cryo-EM | 7SHE | 7SHE_refined | 3.4 | A | Inactive | - | 45 | - | - | - | - | - | - |
Apo (no ligand)
|
none | Apo (no ligand) | - | - | No | No | Patil DN, Singh S, Laboute T, Strutzenberg TS, Qiu X, Wu D, Novick SJ, Robinson CV, Griffin PR, Hunt JF, Izard T, Singh AK, Martemyanov KA | 10.1126/SCIENCE.ABL4732 | 2021-12-01 | Yes | |
| GP158 | GPR158 | C Orphans | C | Human | Cryo-EM | 7SHF | 7SHF_refined | 3.4 | B | Inactive | - | 23 | - | - | - | - | - | - |
Apo (no ligand)
|
none | Apo (no ligand) | - | - | No | No | Patil DN, Singh S, Laboute T, Strutzenberg TS, Qiu X, Wu D, Novick SJ, Robinson CV, Griffin PR, Hunt JF, Izard T, Singh AK, Martemyanov KA | 10.1126/SCIENCE.ABL4732 | 2021-12-01 | Yes | |
| GP158 | GPR158 | C Orphans | C | Human | Cryo-EM | 7EWL | 7EWL_refined | 3.5 | A | Inactive | - | 41 | - | - | - | - | - | - |
Apo (no ligand)
|
none | Apo (no ligand) | - | - | No | No | Jeong E, Kim Y, Jeong J, Cho Y | 10.1038/S41467-021-27147-1 | 2021-12-01 | Yes | |
| MRGX2 | MRGPRX2 | A orphans | A | Human | Cryo-EM | 7VUZ | 7VUZ_refined | 2.9 | R | Active | 100 | 76 | Gi/o | αi1 | - | 62 | - | scFv16 |
PAMP-12
|
peptide | Agonist | PAMP-20 | peptide | No | No | Yang F, Guo L, Li Y, Wang G, Wang J, Zhang C, Fang GX, Chen X, Liu L, Yan X, Liu Q, Qu C, Xu Y, Xiao P, Zhu Z, Li Z, Zhou J, Yu X, Gao N, Sun JP | 10.1038/S41586-021-04077-Y | 2021-12-01 | Yes | |
| MRGX2 | MRGPRX2 | A orphans | A | Human | Cryo-EM | 7VUY | - | 2.8 | R | Active | 100 | 78 | Gi/o | αi1 | - | 64 | - | scFv16 |
PAMP-12
|
peptide | Agonist | PAMP-20 | peptide | No | No | Yang F, Guo L, Li Y, Wang G, Wang J, Zhang C, Fang GX, Chen X, Liu L, Yan X, Liu Q, Qu C, Xu Y, Xiao P, Zhu Z, Li Z, Zhou J, Yu X, Gao N, Sun JP | 10.1038/S41586-021-04077-Y | 2021-12-01 | Yes | |
| MRGX2 | MRGPRX2 | A orphans | A | Human | Cryo-EM | 7VV3 | - | 3.0 | R | Active | 100 | 79 | Gi/o | αi1 | - | 62 | - | scFv16 |
Cortistatin 14
|
peptide | Agonist | PAMP-20 | peptide | No | No | Yang F, Guo L, Li Y, Wang G, Wang J, Zhang C, Fang GX, Chen X, Liu L, Yan X, Liu Q, Qu C, Xu Y, Xiao P, Zhu Z, Li Z, Zhou J, Yu X, Gao N, Sun JP | 10.1038/S41586-021-04077-Y | 2021-12-01 | Yes | |
| MRGX2 | MRGPRX2 | A orphans | A | Human | Cryo-EM | 7VDL | - | 3.2 | R | Active | 100 | 78 | Gi/o | αi1 | - | 61 | - | scFv16 |
Cortistatin 14
|
peptide | Agonist | PAMP-20 | peptide | No | No | Yang F, Guo L, Li Y, Wang G, Wang J, Zhang C, Fang GX, Chen X, Liu L, Yan X, Liu Q, Qu C, Xu Y, Xiao P, Zhu Z, Li Z, Zhou J, Yu X, Gao N, Sun JP | 10.1038/S41586-021-04077-Y | 2021-12-01 | Yes | |
| MRGX2 | MRGPRX2 | A orphans | A | Human | Cryo-EM | 7VV5 | 7VV5_refined | 2.8 | R | Active | 100 | 81 | Gi/o | αi1 | - | 64 | - | scFv16 |
compound 48/80
|
small-molecule | Agonist | PAMP-20 | peptide | No | No | Yang F, Guo L, Li Y, Wang G, Wang J, Zhang C, Fang GX, Chen X, Liu L, Yan X, Liu Q, Qu C, Xu Y, Xiao P, Zhu Z, Li Z, Zhou J, Yu X, Gao N, Sun JP | 10.1038/S41586-021-04077-Y | 2021-12-01 | Yes | |
| MRGX2 | MRGPRX2 | A orphans | A | Human | Cryo-EM | 7VV4 | 7VV4_refined | 3.0 | R | Active | 98 | 80 | - | - | - | - | - | - |
Cortistatin 14
|
peptide | Agonist | PAMP-20 | peptide | No | No | Yang F, Guo L, Li Y, Wang G, Wang J, Zhang C, Fang GX, Chen X, Liu L, Yan X, Liu Q, Qu C, Xu Y, Xiao P, Zhu Z, Li Z, Zhou J, Yu X, Gao N, Sun JP | 10.1038/S41586-021-04077-Y | 2021-12-01 | Yes | |
| MRGX2 | MRGPRX2 | A orphans | A | Human | Cryo-EM | 7VDM | 7VDM_refined | 3.0 | R | Active | 100 | 77 | Gi/o | αi1 | - | 61 | - | scFv16 |
substance P
|
peptide | Agonist | PAMP-20 | peptide | No | No | Yang F, Guo L, Li Y, Wang G, Wang J, Zhang C, Fang GX, Chen X, Liu L, Yan X, Liu Q, Qu C, Xu Y, Xiao P, Zhu Z, Li Z, Zhou J, Yu X, Gao N, Sun JP | 10.1038/S41586-021-04077-Y | 2021-12-01 | Yes | |
| MRGX2 | MRGPRX2 | A orphans | A | Human | Cryo-EM | 7VDH | - | 2.9 | R | Active | 100 | 81 | Gi/o | αi1 | - | 62 | - | scFv16 |
compound 48/80
|
small-molecule | Agonist | PAMP-20 | peptide | No | No | Yang F, Guo L, Li Y, Wang G, Wang J, Zhang C, Fang GX, Chen X, Liu L, Yan X, Liu Q, Qu C, Xu Y, Xiao P, Zhu Z, Li Z, Zhou J, Yu X, Gao N, Sun JP | 10.1038/S41586-021-04077-Y | 2021-12-01 | Yes | |
| MRGX2 | MRGPRX2 | A orphans | A | Human | Cryo-EM | 7VV6 | 7VV6_refined | 3.3 | R | Active | 98 | 82 | - | - | - | - | - | - |
compound 48/80
|
small-molecule | Agonist | PAMP-20 | peptide | No | No | Yang F, Guo L, Li Y, Wang G, Wang J, Zhang C, Fang GX, Chen X, Liu L, Yan X, Liu Q, Qu C, Xu Y, Xiao P, Zhu Z, Li Z, Zhou J, Yu X, Gao N, Sun JP | 10.1038/S41586-021-04077-Y | 2021-12-01 | Yes | |
| MRGX2 | MRGPRX2 | A orphans | A | Human | Cryo-EM | 7VV0 | 7VV0_refined | 3.5 | R | Active | 98 | 80 | - | - | - | - | - | - |
PAMP-12
|
peptide | Agonist | PAMP-20 | peptide | No | No | Yang F, Guo L, Li Y, Wang G, Wang J, Zhang C, Fang GX, Chen X, Liu L, Yan X, Liu Q, Qu C, Xu Y, Xiao P, Zhu Z, Li Z, Zhou J, Yu X, Gao N, Sun JP | 10.1038/S41586-021-04077-Y | 2021-12-01 | Yes | |
| CNR1 | CB1 | Cannabinoid | A | Human | X-ray | 7V3Z | 7V3Z_refined | 3.3 | A | Active | 91 | 60 | - | - | - | - | Flavodoxin | - |
CP55940
|
small-molecule | Agonist | 2-arachidonoylglycerol, anandamide | small-molecule | No | No | Wang X, Liu D, Shen L, Li F, Li Y, Yang L, Xu T, Tao H, Yao D, Wu L, Hirata K, Bohn LM, Makriyannis A, Liu X, Hua T, Liu ZJ, Wang J | 10.1021/JACS.1C06847 | 2021-11-24 | Yes | |
| ADRB1 | β1 | Adrenoceptors | A | Wild turkey | Cryo-EM | 7S0G | - | 3.9 | R | Active | 100 | 57 | Gs | αs | Gi1-Gs chimera | 56 | - | - |
LEVISOPRENALINE
|
small-molecule | Agonist | - | - | No | No | Alegre KO, Paknejad N, Su M, Lou JS, Huang J, Jordan KD, Eng ET, Meyerson JR, Hite RK, Huang XY | 10.1038/S41594-021-00679-2 | 2021-11-17 | Yes | |
| ADRB1 | β1 | Adrenoceptors | A | Wild turkey | Cryo-EM | 7S0F | - | 3.0 | R | Active | 100 | 56 | Gi/o | αi1 | - | 63 | - | - |
LEVISOPRENALINE
|
small-molecule | Agonist | - | - | No | No | Alegre KO, Paknejad N, Su M, Lou JS, Huang J, Jordan KD, Eng ET, Meyerson JR, Hite RK, Huang XY | 10.1038/S41594-021-00679-2 | 2021-11-17 | Yes | |
| MC4R | MC4 | Melanocortin | A | Human | Cryo-EM | 7PIU | - | 2.6 | R | Active | 100 | 78 | Gs | αs | - | 48 | - | Nanobody-35 |
setmelanotide
|
peptide | Agonist | γ-MSH, α-MSH, β-MSH, ACTH, agouti-related protein | peptide | No | No | Heyder NA, Kleinau G, Speck D, Schmidt A, Paisdzior S, Szczepek M, Bauer B, Koch A, Gallandi M, Kwiatkowski D, Burger J, Mielke T, Beck-Sickinger AG, Hildebrand PW, Spahn CMT, Hilger D, Schacherl M, Biebermann H, Hilal T, Kuhnen P, Kobilka BK, Scheerer P | 10.1038/S41422-021-00569-8 | 2021-11-17 | Yes | |
| MC4R | MC4 | Melanocortin | A | Human | Cryo-EM | 7PIV | 7PIV_refined | 2.9 | R | Active | 100 | 78 | Gs | αs | - | 46 | - | Nanobody-35 |
afamelanotide
|
peptide | Agonist | γ-MSH, α-MSH, β-MSH, ACTH, agouti-related protein | peptide | No | No | Heyder NA, Kleinau G, Speck D, Schmidt A, Paisdzior S, Szczepek M, Bauer B, Koch A, Gallandi M, Kwiatkowski D, Burger J, Mielke T, Beck-Sickinger AG, Hildebrand PW, Spahn CMT, Hilger D, Schacherl M, Biebermann H, Hilal T, Kuhnen P, Kobilka BK, Scheerer P | 10.1038/S41422-021-00569-8 | 2021-11-17 | Yes | |
| MRGX2 | MRGPRX2 | A orphans | A | Human | Cryo-EM | 7S8O | - | 2.6 | R | Active | 100 | 78 | Gi/o | αi1 | - | 62 | BRIL | scFv16 |
(R)-ZINC-3573
|
small-molecule | Agonist | PAMP-20 | peptide | No | No | Cao C, Kang HJ, Singh I, Chen H, Zhang C, Ye W, Hayes BW, Liu J, Gumpper RH, Bender BJ, Slocum ST, Krumm BE, Lansu K, McCorvy JD, Kroeze WK, English JG, DiBerto JF, Olsen RHJ, Huang XP, Zhang S, Liu Y, Kim K, Karpiak J, Jan LY, Abraham SN, Jin J, Shoichet BK, Fay JF, Roth BL | 10.1038/S41586-021-04126-6 | 2021-11-17 | Yes | |
| MRGX2 | MRGPRX2 | A orphans | A | Human | Cryo-EM | 7S8N | 7S8N_refined | 2.9 | R | Active | 100 | 76 | Gq/11 | αq | Gq-Gs chimera | 57 | - | scFv16 |
(R)-ZINC-3573
|
small-molecule | Agonist | PAMP-20 | peptide | No | No | Cao C, Kang HJ, Singh I, Chen H, Zhang C, Ye W, Hayes BW, Liu J, Gumpper RH, Bender BJ, Slocum ST, Krumm BE, Lansu K, McCorvy JD, Kroeze WK, English JG, DiBerto JF, Olsen RHJ, Huang XP, Zhang S, Liu Y, Kim K, Karpiak J, Jan LY, Abraham SN, Jin J, Shoichet BK, Fay JF, Roth BL | 10.1038/S41586-021-04126-6 | 2021-11-17 | Yes | |
| MRGX2 | MRGPRX2 | A orphans | A | Human | Cryo-EM | 7S8L | - | 2.5 | R | Active | 100 | 76 | Gq/11 | αq | Gq-Gs chimera | 57 | - | scFv16 |
Cortistatin 14
|
peptide | Agonist | PAMP-20 | peptide | No | No | Cao C, Kang HJ, Singh I, Chen H, Zhang C, Ye W, Hayes BW, Liu J, Gumpper RH, Bender BJ, Slocum ST, Krumm BE, Lansu K, McCorvy JD, Kroeze WK, English JG, DiBerto JF, Olsen RHJ, Huang XP, Zhang S, Liu Y, Kim K, Karpiak J, Jan LY, Abraham SN, Jin J, Shoichet BK, Fay JF, Roth BL | 10.1038/S41586-021-04126-6 | 2021-11-17 | Yes | |
| MRGX2 | MRGPRX2 | A orphans | A | Human | Cryo-EM | 7S8M | - | 2.5 | R | Active | 100 | 77 | Gi/o | αi1 | - | 62 | BRIL | scFv16 |
Cortistatin 14
|
peptide | Agonist | PAMP-20 | peptide | No | No | Cao C, Kang HJ, Singh I, Chen H, Zhang C, Ye W, Hayes BW, Liu J, Gumpper RH, Bender BJ, Slocum ST, Krumm BE, Lansu K, McCorvy JD, Kroeze WK, English JG, DiBerto JF, Olsen RHJ, Huang XP, Zhang S, Liu Y, Kim K, Karpiak J, Jan LY, Abraham SN, Jin J, Shoichet BK, Fay JF, Roth BL | 10.1038/S41586-021-04126-6 | 2021-11-17 | Yes | |
| MRGX4 | MRGPRX4 | A orphans | A | Human | Cryo-EM | 7S8P | 7S8P_refined | 2.6 | R | Active | 100 | 77 | Gq/11 | αq | Gq-Gs chimera | 57 | BRIL | scFv16 |
N-[(1r,3R,5S,7R)-3,5-dimethyltricyclo[3.3.1.1~3,7~]decane-1-carbonyl]-D-phenylalanine
|
small-molecule | Agonist | - | - | No | No | Cao C, Kang HJ, Singh I, Chen H, Zhang C, Ye W, Hayes BW, Liu J, Gumpper RH, Bender BJ, Slocum ST, Krumm BE, Lansu K, McCorvy JD, Kroeze WK, English JG, DiBerto JF, Olsen RHJ, Huang XP, Zhang S, Liu Y, Kim K, Karpiak J, Jan LY, Abraham SN, Jin J, Shoichet BK, Fay JF, Roth BL | 10.1038/S41586-021-04126-6 | 2021-11-17 | Yes | |
| MC4R | MC4 | Melanocortin | A | Human | Cryo-EM | 7F58 | 7F58_refined | 3.1 | R | Active | 100 | 82 | Gs | αs | - | 58 | - | Nanobody-35 |
THIQ
|
small-molecule | Agonist | γ-MSH, α-MSH, β-MSH, ACTH, agouti-related protein | peptide | No | No | Zhang H, Chen LN, Yang D, Mao C, Shen Q, Feng W, Shen DD, Dai A, Xie S, Zhou Y, Qin J, Sun JP, Scharf DH, Hou T, Zhou T, Wang MW, Zhang Y | 10.1038/S41422-021-00552-3 | 2021-11-03 | Yes | |
| MC4R | MC4 | Melanocortin | A | Human | Cryo-EM | 7F54 | - | 3.0 | R | Active | 100 | 82 | Gs | αs | - | 58 | - | Nanobody-35 |
afamelanotide
|
peptide | Agonist | γ-MSH, α-MSH, β-MSH, ACTH, agouti-related protein | peptide | No | No | - | - | 2021-11-03 | Yes | |
| MC4R | MC4 | Melanocortin | A | Human | Cryo-EM | 7F53 | - | 3.0 | R | Active | 100 | 82 | Gs | αs | - | 58 | - | Nanobody-35 |
α-MSH
|
peptide | Agonist | γ-MSH, α-MSH, β-MSH, ACTH, agouti-related protein | peptide | No | No | - | - | 2021-11-03 | Yes | |
| MC4R | MC4 | Melanocortin | A | Human | Cryo-EM | 7F55 | - | 3.1 | R | Active | 100 | 82 | Gs | αs | - | 58 | - | Nanobody-35 |
bremelanotide
|
peptide | Agonist | γ-MSH, α-MSH, β-MSH, ACTH, agouti-related protein | peptide | No | No | - | - | 2021-11-03 | Yes | |
| NK1R | NK1 | Tachykinin | A | Human | Cryo-EM | 7RMG | - | 3.0 | R | Active | 100 | 71 | Gq/11 | αq | Gs-Gq chimera | 52 | - | Nanobody-35 |
substance P
|
peptide | Agonist | neurokinin A, neuropeptide K, hemokinin 1, neurokinin B, neuropeptide-γ, substance P | peptide | No | No | Harris JA, Faust B, Gondin AB, Damgen MA, Suomivuori CM, Veldhuis NA, Cheng Y, Dror RO, Thal DM, Manglik A | 10.1038/S41589-021-00890-8 | 2021-11-03 | Yes | |
| NK1R | NK1 | Tachykinin | A | Human | Cryo-EM | 7RMI | - | 3.2 | R | Active | 100 | 70 | Gs | αs | Gs-Gq chimera | 49 | - | Nanobody-35 |
substance P
|
peptide | Agonist | neurokinin A, neuropeptide K, hemokinin 1, neurokinin B, neuropeptide-γ, substance P | peptide | No | No | Harris JA, Faust B, Gondin AB, Damgen MA, Suomivuori CM, Veldhuis NA, Cheng Y, Dror RO, Thal DM, Manglik A | 10.1038/S41589-021-00890-8 | 2021-11-03 | Yes | |
| NK1R | NK1 | Tachykinin | A | Human | Cryo-EM | 7RMH | 7RMH_refined | 3.1 | R | Active | 100 | 70 | Gs | αs | - | 55 | - | Nanobody-35 |
substance P
|
peptide | Agonist | neurokinin A, neuropeptide K, hemokinin 1, neurokinin B, neuropeptide-γ, substance P | peptide | No | No | Harris JA, Faust B, Gondin AB, Damgen MA, Suomivuori CM, Veldhuis NA, Cheng Y, Dror RO, Thal DM, Manglik A | 10.1038/S41589-021-00890-8 | 2021-11-03 | Yes | |
| GHRHR | GHRH | Glucagon | B1 | Human | Cryo-EM | 7V9M | 7V9M_refined | 3.3 | R | Active | 100 | 63 | Gs | αs | - | 57 | - | Nanobody-35 |
Somatoliberin
|
peptide | Agonist | GHRH | peptide | No | No | Cong Z, Zhou F, Zhang C, Zou X, Zhang H, Wang Y, Zhou Q, Cai X, Liu Q, Li J, Shao L, Mao C, Wang X, Wu J, Xia T, Zhao LH, Jiang H, Zhang Y, Xu HE, Cheng X, Yang D, Wang MW | 10.1073/PNAS.2106606118 | 2021-10-20 | Yes | |
| BKRB1 | B1 | Bradykinin | A | Human | Cryo-EM | 7EIB | - | 3.0 | A | Active | 100 | 84 | Gq/11 | αq | Gq-Gi1 chimera | 61 | - | - |
[des-Arg10]kallidin
|
peptide | Agonist | T-kinin, kallidin, Lys-[Hyp3]-bradykinin, bradykinin, [des-Arg10]kallidin, [Hyp3]bradykinin, [des-Arg9]bradykinin | peptide | No | No | Yin YL, Ye C, Zhou F, Wang J, Yang D, Yin W, Wang MW, Xu HE, Jiang Y | 10.1038/S41594-021-00645-Y | 2021-10-13 | Yes | |
| BKRB2 | B2 | Bradykinin | A | Human | Cryo-EM | 7F2O | - | 2.9 | R | Active | 100 | 73 | Gq/11 | αq | Gq-Gi1 chimera | 60 | - | scFv16 |
bradykinin
|
peptide | Agonist | T-kinin, kallidin, Lys-[Hyp3]-bradykinin, bradykinin, [des-Arg10]kallidin, [Hyp3]bradykinin, [des-Arg9]bradykinin | peptide | No | No | Yin YL, Ye C, Zhou F, Wang J, Yang D, Yin W, Wang MW, Xu HE, Jiang Y | 10.1038/S41594-021-00645-Y | 2021-10-13 | Yes | |
| CCKAR | CCK1 | Cholecystokinin | A | Human | X-ray | 7F8U | 7F8U_refined | 2.8 | A | Inactive | 1 | 65 | - | - | - | - | T4-Lysozyme | - |
lintitript
|
small-molecule | Antagonist | CCK-39, gastrin-17, desulfated cholecystokinin-8, CCK-4, CCK-58, CCK-8, CCK-33 | peptide | No | No | Zhang X, He C, Wang M, Zhou Q, Yang D, Zhu Y, Feng W, Zhang H, Dai A, Chu X, Wang J, Yang Z, Jiang Y, Sensfuss U, Tan Q, Han S, Reedtz-Runge S, Xu HE, Zhao S, Wang MW, Wu B, Zhao Q | 10.1038/S41589-021-00866-8 | 2021-10-13 | Yes | |
| CCKAR | CCK1 | Cholecystokinin | A | Human | X-ray | 7F8Y | 7F8Y_refined | 2.5 | A | Inactive | 1 | 65 | - | - | - | - | T4-Lysozyme | - |
DEVAZEPIDE
|
small-molecule | Antagonist | CCK-39, gastrin-17, desulfated cholecystokinin-8, CCK-4, CCK-58, CCK-8, CCK-33 | peptide | No | No | Zhang X, He C, Wang M, Zhou Q, Yang D, Zhu Y, Feng W, Zhang H, Dai A, Chu X, Wang J, Yang Z, Jiang Y, Sensfuss U, Tan Q, Han S, Reedtz-Runge S, Xu HE, Zhao S, Wang MW, Wu B, Zhao Q | 10.1038/S41589-021-00866-8 | 2021-10-13 | Yes | |
| GASR | CCK2 | Cholecystokinin | A | Human | Cryo-EM | 7F8W | 7F8W_refined | 3.1 | R | Active | 100 | 62 | Gq/11 | αq | Gq-Gi1 chimera | 62 | - | scFv16 |
desulfated gastrin-17
|
peptide | Agonist | CCK-39, desulfated gastrin-14, gastrin-71, desulfated gastrin-71, desulfated gastrin-17, gastrin-17, desulfated gastrin-34, desulfated cholecystokinin-8, gastrin-14, CCK-4, CCK-58, gastrin-34, CCK-8, CCK-33 | peptide | No | No | Zhang X, He C, Wang M, Zhou Q, Yang D, Zhu Y, Feng W, Zhang H, Dai A, Chu X, Wang J, Yang Z, Jiang Y, Sensfuss U, Tan Q, Han S, Reedtz-Runge S, Xu HE, Zhao S, Wang MW, Wu B, Zhao Q | 10.1038/S41589-021-00866-8 | 2021-10-13 | Yes | |
| GASR | CCK2 | Cholecystokinin | A | Human | Cryo-EM | 7F8V | - | 3.3 | R | Active | 100 | 62 | Gi/o | αi2 | - | 61 | - | - |
desulfated gastrin-17
|
peptide | Agonist | CCK-39, desulfated gastrin-14, gastrin-71, desulfated gastrin-71, desulfated gastrin-17, gastrin-17, desulfated gastrin-34, desulfated cholecystokinin-8, gastrin-14, CCK-4, CCK-58, gastrin-34, CCK-8, CCK-33 | peptide | No | No | Zhang X, He C, Wang M, Zhou Q, Yang D, Zhu Y, Feng W, Zhang H, Dai A, Chu X, Wang J, Yang Z, Jiang Y, Sensfuss U, Tan Q, Han S, Reedtz-Runge S, Xu HE, Zhao S, Wang MW, Wu B, Zhao Q | 10.1038/S41589-021-00866-8 | 2021-10-13 | Yes | |
| ACM1 | M1 | Acetylcholine (muscarinic) | A | Human | X-ray | 6ZG9 | 6ZG9_refined | 2.5 | A | Inactive | 3 | 62 | - | - | - | - | T4-Lysozyme | - |
7-fluoro-5-methyl-3-[1-(oxan-4-yl)piperidin-4-yl]-1H-benzimidazol-2-one
|
small-molecule | Agonist | acetylcholine | small-molecule | No | No | Brown AJH, Bradley SJ, Marshall FH, Brown GA, Bennett KA, Brown J, Cansfield JE, Cross DM, de Graaf C, Hudson BD, Dwomoh L, Dias JM, Errey JC, Hurrell E, Liptrot J, Mattedi G, Molloy C, Nathan PJ, Okrasa K, Osborne G, Patel JC, Pickworth M, Robertson N, Shahabi S, Bundgaard C, Phillips K, Broad LM, Goonawardena AV, Morairty SR, Browning M, Perini F, Dawson GR, Deakin JFW, Smith RT, Sexton PM, Warneck J, Vinson M, Tasker T, Tehan BG, Teobald B, Christopoulos A, Langmead CJ, Jazayeri A, Cooke RM, Rucktooa P, Congreve MS, Weir M, Tobin AB | 10.1016/J.CELL.2021.11.001 | 2021-10-06 | Yes | |
| ACM1 | M1 | Acetylcholine (muscarinic) | A | Human | X-ray | 6ZFZ | 6ZFZ_refined | 2.2 | A | Inactive | 3 | 62 | - | - | - | - | T4-Lysozyme | - |
CHEMBL3354065
|
small-molecule | Agonist | acetylcholine | small-molecule | No | No | Brown AJH, Bradley SJ, Marshall FH, Brown GA, Bennett KA, Brown J, Cansfield JE, Cross DM, de Graaf C, Hudson BD, Dwomoh L, Dias JM, Errey JC, Hurrell E, Liptrot J, Mattedi G, Molloy C, Nathan PJ, Okrasa K, Osborne G, Patel JC, Pickworth M, Robertson N, Shahabi S, Bundgaard C, Phillips K, Broad LM, Goonawardena AV, Morairty SR, Browning M, Perini F, Dawson GR, Deakin JFW, Smith RT, Sexton PM, Warneck J, Vinson M, Tasker T, Tehan BG, Teobald B, Christopoulos A, Langmead CJ, Jazayeri A, Cooke RM, Rucktooa P, Congreve MS, Weir M, Tobin AB | 10.1016/J.CELL.2021.11.001 | 2021-10-06 | Yes | |
| ACM1 | M1 | Acetylcholine (muscarinic) | A | Human | X-ray | 6ZG4 | 6ZG4_refined | 2.3 | A | Inactive | 3 | 62 | - | - | - | - | T4-Lysozyme | - |
HTL-9936
|
small-molecule | Agonist | acetylcholine | small-molecule | No | No | - | - | 2021-10-06 | Yes | |
| GLP1R | GLP-1 | Glucagon | B1 | Human | Cryo-EM | 7RTB | 7RTB_refined | 2.1 | R | Active | 100 | 83 | Gs | αs | - | 60 | - | Nanobody-35 |
Peptide-19
|
peptide | Agonist | glucagon-like peptide 1-(7-36) amide, glucagon, glucagon-like peptide 1-(7-37) | peptide | No | No | Johnson RM, Zhang X, Piper SJ, Nettleton TJ, Vandekolk TH, Langmead CJ, Danev R, Sexton PM, Wootten D | 10.1016/J.BBRC.2021.09.016 | 2021-10-06 | Yes | |
| LSHR | LH | Glycoprotein hormone | A | Human | Cryo-EM | 7FIJ | 7FIJ_refined | 3.8 | R | Inactive | 8 | 80 | - | - | - | - | - | - |
Apo (no ligand)
|
none | Apo (no ligand) | LH, hCG | peptide | No | No | Duan J, Xu P, Cheng X, Mao C, Croll T, He X, Shi J, Luan X, Yin W, You E, Liu Q, Zhang S, Jiang H, Zhang Y, Jiang Y, Xu HE | 10.1038/S41586-021-03924-2 | 2021-09-29 | Yes | |
| LSHR | LH | Glycoprotein hormone | A | Human | Cryo-EM | 7FII | - | 4.3 | R | Active | 100 | 82 | Gs | αs | - | 91 | - | - |
Glycoprotein alpha
Choriogonadotropin beta |
protein protein |
Agonist | LH, hCG | peptide | No | No | Duan J, Xu P, Cheng X, Mao C, Croll T, He X, Shi J, Luan X, Yin W, You E, Liu Q, Zhang S, Jiang H, Zhang Y, Jiang Y, Xu HE | 10.1038/S41586-021-03924-2 | 2021-09-29 | Yes | |
| LSHR | LH | Glycoprotein hormone | A | Human | Cryo-EM | 7FIH | - | 3.2 | R | Active | 100 | 79 | Gs | αs | - | 60 | - | - |
Glycoprotein alpha
Choriogonadotropin beta 5-Amino-N-(1,1-dimethylethyl)-2-(methylthio)-4-[3-[[2-(4-morpholinyl)acetyl]amino]phenyl]thieno[2,3-d]pyrimidine-6-carboxamide |
protein protein small-molecule |
Agonist | LH, hCG | peptide | No | No | Duan J, Xu P, Cheng X, Mao C, Croll T, He X, Shi J, Luan X, Yin W, You E, Liu Q, Zhang S, Jiang H, Zhang Y, Jiang Y, Xu HE | 10.1038/S41586-021-03924-2 | 2021-09-29 | Yes | |
| LSHR | LH | Glycoprotein hormone | A | Human | Cryo-EM | 7FIG | - | 3.9 | R | Active | 100 | 79 | Gs | αs | - | 91 | - | Nanobody-35 |
Glycoprotein alpha
Choriogonadotropin beta |
protein protein |
Agonist | LH, hCG | peptide | No | No | Duan J, Xu P, Cheng X, Mao C, Croll T, He X, Shi J, Luan X, Yin W, You E, Liu Q, Zhang S, Jiang H, Zhang Y, Jiang Y, Xu HE | 10.1038/S41586-021-03924-2 | 2021-09-29 | Yes | |
| S1PR1 | S1P1 | Lysophospholipid (S1P) | A | Human | Cryo-EM | 7EVY | - | 3.0 | D | Active | 100 | 71 | Gi/o | αi1 | - | 64 | - | scFv16 |
siponimod
|
small-molecule | Agonist | dihydrosphingosine 1-phosphate, sphingosylphosphorylcholine, sphingosine 1-phosphate | small-molecule | No | No | Yuan Y, Jia G, Wu C, Wang W, Cheng L, Li Q, Li Z, Luo K, Yang S, Yan W, Su Z, Shao Z | 10.1038/S41422-021-00566-X | 2021-09-29 | Yes | |
| S1PR1 | S1P1 | Lysophospholipid (S1P) | A | Human | Cryo-EM | 7EW0 | 7EW0_refined | 3.4 | D | Active | 100 | 71 | Gi/o | αi1 | - | 64 | - | scFv16 |
ozanimod
|
small-molecule | Agonist | dihydrosphingosine 1-phosphate, sphingosylphosphorylcholine, sphingosine 1-phosphate | small-molecule | No | No | Yuan Y, Jia G, Wu C, Wang W, Cheng L, Li Q, Li Z, Luo K, Yang S, Yan W, Su Z, Shao Z | 10.1038/S41422-021-00566-X | 2021-09-29 | Yes | |
| S1PR1 | S1P1 | Lysophospholipid (S1P) | A | Human | Cryo-EM | 7EVZ | - | 3.1 | D | Active | 100 | 71 | Gi/o | αi1 | - | 64 | - | scFv16 |
cenerimod
|
small-molecule | Agonist | dihydrosphingosine 1-phosphate, sphingosylphosphorylcholine, sphingosine 1-phosphate | small-molecule | No | No | Yuan Y, Jia G, Wu C, Wang W, Cheng L, Li Q, Li Z, Luo K, Yang S, Yan W, Su Z, Shao Z | 10.1038/S41422-021-00566-X | 2021-09-29 | Yes | |
| S1PR1 | S1P1 | Lysophospholipid (S1P) | A | Human | Cryo-EM | 7EW7 | - | 3.3 | D | Active | 100 | 75 | Gi/o | αi1 | - | 64 | - | scFv16 |
SEW2871
|
small-molecule | Agonist | dihydrosphingosine 1-phosphate, sphingosylphosphorylcholine, sphingosine 1-phosphate | small-molecule | No | No | Yuan Y, Jia G, Wu C, Wang W, Cheng L, Li Q, Li Z, Luo K, Yang S, Yan W, Su Z, Shao Z | 10.1038/S41422-021-00566-X | 2021-09-29 | Yes | |
| S1PR3 | S1P3 | Lysophospholipid (S1P) | A | Human | Cryo-EM | 7EW3 | - | 3.1 | R | Active | 100 | 77 | Gi/o | αi1 | - | 64 | - | scFv16 |
Sphingosine 1-phosphate
|
lipid | Agonist | dihydrosphingosine 1-phosphate, sphingosylphosphorylcholine, sphingosine 1-phosphate | small-molecule | No | No | Zhao C, Cheng L, Wang W, Wang H, Luo Y, Feng Y, Wang X, Fu H, Cai Y, Yang S, Fu P, Yan W, Shao Z | 10.1038/S41422-021-00567-W | 2021-09-29 | Yes | |
| S1PR3 | S1P3 | Lysophospholipid (S1P) | A | Human | Cryo-EM | 7EW4 | 7EW4_refined | 3.2 | R | Active | 100 | 76 | Gi/o | αi1 | - | 64 | - | scFv16 |
CYM-5541
|
small-molecule | Agonist | dihydrosphingosine 1-phosphate, sphingosylphosphorylcholine, sphingosine 1-phosphate | small-molecule | No | No | Zhao C, Cheng L, Wang W, Wang H, Luo Y, Feng Y, Wang X, Fu H, Cai Y, Yang S, Fu P, Yan W, Shao Z | 10.1038/S41422-021-00567-W | 2021-09-29 | Yes | |
| S1PR3 | S1P3 | Lysophospholipid (S1P) | A | Human | Cryo-EM | 7EW2 | - | 3.1 | R | Active | 100 | 77 | Gi/o | αi1 | - | 64 | - | scFv16 |
(S)-FTY720-phosphate
|
small-molecule | Agonist | dihydrosphingosine 1-phosphate, sphingosylphosphorylcholine, sphingosine 1-phosphate | small-molecule | No | No | Zhao C, Cheng L, Wang W, Wang H, Luo Y, Feng Y, Wang X, Fu H, Cai Y, Yang S, Fu P, Yan W, Shao Z | 10.1038/S41422-021-00567-W | 2021-09-29 | Yes | |
| S1PR5 | S1P5 | Lysophospholipid (S1P) | A | Human | Cryo-EM | 7EW1 | 7EW1_refined | 3.4 | A | Active | 100 | 68 | Gi/o | αi1 | - | 64 | - | scFv16 |
siponimod
|
small-molecule | Agonist | dihydrosphingosine 1-phosphate, sphingosylphosphorylcholine, sphingosine 1-phosphate | small-molecule | No | No | Yuan Y, Jia G, Wu C, Wang W, Cheng L, Li Q, Li Z, Luo K, Yang S, Yan W, Su Z, Shao Z | 10.1038/S41422-021-00566-X | 2021-09-29 | Yes | |
| CASR | CaS | Calcium-sensing | C | Human | Cryo-EM | 7E6U | 7E6U_refined | 6.0 | A | Inactive | - | 72 | - | - | - | - | - | Nanobody-2D11 |
Apo (no ligand)
|
none | Apo (no ligand) | Mg2+, L-tryptophan, spermine, Ca2+ | small-molecule | No | No | Chen X, Wang L, Cui Q, Ding Z, Han L, Kou Y, Zhang W, Wang H, Jia X, Dai M, Shi Z, Li Y, Li X, Geng Y | 10.7554/ELIFE.68578 | 2021-09-22 | Yes | |
| CASR | CaS | Calcium-sensing | C | Human | Cryo-EM | 7E6T | 7E6T_refined | 3.0 | A | Active | - | 74 | - | - | - | - | - | - |
Calcium
Cyclomethyltryptophan |
small-molecule small-molecule |
Agonist PAM |
Mg2+, L-tryptophan, spermine, Ca2+ | small-molecule | No | No | Chen X, Wang L, Cui Q, Ding Z, Han L, Kou Y, Zhang W, Wang H, Jia X, Dai M, Shi Z, Li Y, Li X, Geng Y | 10.7554/ELIFE.68578 | 2021-09-22 | Yes | |
| GRM1 | mGlu1 | Metabotropic glutamate | C | Human | Cryo-EM | 7DGE | 7DGE_refined | 3.7 | A | Intermediate | - | 66 | - | - | - | - | - | Nanobody-43 |
quisqualate
|
small-molecule | Agonist | L-glutamic acid | small-molecule | No | No | Zhang J, Qu L, Wu L, Tang X, Luo F, Xu W, Xu Y, Liu ZJ, Hua T | 10.1007/S13238-020-00808-5 | 2021-09-22 | Yes | |
| GRM1 | mGlu1 | Metabotropic glutamate | C | Human | Cryo-EM | 7DGD | 7DGD_refined | 4.0 | A | Inactive | - | 66 | - | - | - | - | - | - |
Apo (no ligand)
|
none | Apo (no ligand) | L-glutamic acid | small-molecule | No | No | Zhang J, Qu L, Wu L, Tang X, Luo F, Xu W, Xu Y, Liu ZJ, Hua T | 10.1007/S13238-020-00808-5 | 2021-09-22 | Yes | |
| AA1R | A1 | Adenosine | A | Human | Cryo-EM | 7LD4 | 7LD4_refined | 3.3 | R | Active | 100 | 88 | Gi/o | αi2 | - | 59 | - | - |
adenosine
|
small-molecule | Agonist | adenosine | small-molecule | No | No | Draper-Joyce CJ, Bhola R, Wang J, Bhattarai A, Nguyen ATN, Cowie-Kent I, O'Sullivan K, Chia LY, Venugopal H, Valant C, Thal DM, Wootten D, Panel N, Carlsson J, Christie MJ, White PJ, Scammells P, May LT, Sexton PM, Danev R, Miao Y, Glukhova A, Imlach WL, Christopoulos A | 10.1038/S41586-021-03897-2 | 2021-09-08 | Yes | |
| AA1R | A1 | Adenosine | A | Human | Cryo-EM | 7LD3 | - | 3.2 | R | Active | 100 | 88 | Gi/o | αi2 | - | 59 | - | - |
{2-Amino-4-[3,5-bis(trifluoromethyl)phenyl]thiophen-3-yl}(4-chlorophenyl)methanone
adenosine |
small-molecule small-molecule |
Ago-PAM Agonist |
adenosine | small-molecule | No | No | Draper-Joyce CJ, Bhola R, Wang J, Bhattarai A, Nguyen ATN, Cowie-Kent I, O'Sullivan K, Chia LY, Venugopal H, Valant C, Thal DM, Wootten D, Panel N, Carlsson J, Christie MJ, White PJ, Scammells P, May LT, Sexton PM, Danev R, Miao Y, Glukhova A, Imlach WL, Christopoulos A | 10.1038/S41586-021-03897-2 | 2021-09-08 | Yes | |
| AA2AR | A2A | Adenosine | A | Human | MicroED | 7RM5 | 7RM5_refined | 2.8 | A | Inactive | 1 | 72 | - | - | - | - | BRIL | - |
ZM-241385
|
small-molecule | Antagonist | adenosine | small-molecule | No | No | Martynowycz MW, Shiriaeva A, Ge X, Hattne J, Nannenga BL, Cherezov V, Gonen T | 10.1073/PNAS.2106041118 | 2021-09-08 | Yes | |
| GRM5 | mGlu5 | Metabotropic glutamate | C | Human | X-ray | 7P2L | 7P2L_refined | 2.5 | A | Inactive | - | 21 | - | - | - | - | T4-Lysozyme | - |
alloswitch-1
|
small-molecule | NAM | L-glutamic acid | small-molecule | No | No | Nasrallah C, Cannone G, Briot J, Rottier K, Berizzi AE, Huang CY, Quast RB, Hoh F, Baneres JL, Malhaire F, Berto L, Dumazer A, Font-Ingles J, Gomez-Santacana X, Catena J, Kniazeff J, Goudet C, Llebaria A, Pin JP, Vinothkumar KR, Lebon G | 10.1016/J.CELREP.2021.109648 | 2021-09-08 | Yes | |
| GRM5 | mGlu5 | Metabotropic glutamate | C | Human | Cryo-EM | 7FD8 | 7FD8_refined | 3.8 | A | Active | - | 63 | - | - | - | - | - | - |
quisqualate
|
small-molecule | Agonist | L-glutamic acid | small-molecule | No | No | Nasrallah C, Cannone G, Briot J, Rottier K, Berizzi AE, Huang CY, Quast RB, Hoh F, Baneres JL, Malhaire F, Berto L, Dumazer A, Font-Ingles J, Gomez-Santacana X, Catena J, Kniazeff J, Goudet C, Llebaria A, Pin JP, Vinothkumar KR, Lebon G | 10.1016/J.CELREP.2021.109648 | 2021-09-08 | Yes | |
| GRM5 | mGlu5 | Metabotropic glutamate | C | Human | Cryo-EM | 7FD9 | 7FD9_refined | 4.0 | A | Inactive | - | 63 | - | - | - | - | - | - |
LY341495
|
small-molecule | Antagonist | L-glutamic acid | small-molecule | No | No | Nasrallah C, Cannone G, Briot J, Rottier K, Berizzi AE, Huang CY, Quast RB, Hoh F, Baneres JL, Malhaire F, Berto L, Dumazer A, Font-Ingles J, Gomez-Santacana X, Catena J, Kniazeff J, Goudet C, Llebaria A, Pin JP, Vinothkumar KR, Lebon G | 10.1016/J.CELREP.2021.109648 | 2021-09-08 | Yes | |
| MSHR | MC1 | Melanocortin | A | Human | Cryo-EM | 7F4H | - | 2.7 | R | Active | 100 | 84 | Gs | αs | - | 59 | - | Nanobody-35 scFv16 |
CHEMBL407070
|
protein | Agonist | γ-MSH, ACTH, β-MSH, α-MSH | peptide | No | No | Ma S, Chen Y, Dai A, Yin W, Guo J, Yang D, Zhou F, Jiang Y, Wang MW, Xu HE | 10.1038/S41422-021-00557-Y | 2021-09-08 | Yes | |
| MSHR | MC1 | Melanocortin | A | Human | Cryo-EM | 7F4F | - | 2.9 | R | Active | 100 | 85 | Gs | αs | - | 59 | - | scFv16 |
CHEMBL407070
|
protein | Agonist | γ-MSH, ACTH, β-MSH, α-MSH | peptide | No | No | Ma S, Chen Y, Dai A, Yin W, Guo J, Yang D, Zhou F, Jiang Y, Wang MW, Xu HE | 10.1038/S41422-021-00557-Y | 2021-09-08 | Yes | |
| MSHR | MC1 | Melanocortin | A | Human | Cryo-EM | 7F4I | 7F4I_refined | 3.1 | R | Active | 100 | 84 | Gs | αs | - | 59 | - | Nanobody-35 |
bremelanotide
|
peptide | Agonist | γ-MSH, ACTH, β-MSH, α-MSH | peptide | No | No | Ma S, Chen Y, Dai A, Yin W, Guo J, Yang D, Zhou F, Jiang Y, Wang MW, Xu HE | 10.1038/S41422-021-00557-Y | 2021-09-08 | Yes | |
| MSHR | MC1 | Melanocortin | A | Human | Cryo-EM | 7F4D | - | 3.0 | R | Active | 100 | 83 | Gs | αs | - | 59 | - | Nanobody-35 |
INTERMEDINE
|
protein | Agonist | γ-MSH, ACTH, β-MSH, α-MSH | peptide | No | No | Ma S, Chen Y, Dai A, Yin W, Guo J, Yang D, Zhou F, Jiang Y, Wang MW, Xu HE | 10.1038/S41422-021-00557-Y | 2021-09-08 | Yes | |
| CCKAR | CCK1 | Cholecystokinin | A | Human | Cryo-EM | 7EZK | - | 3.1 | D | Active | 100 | 69 | Gs | αs | - | 58 | - | - |
CCK-8
|
peptide | Agonist | CCK-39, gastrin-17, desulfated cholecystokinin-8, CCK-4, CCK-58, CCK-8, CCK-33 | peptide | No | No | Liu Q, Yang D, Zhuang Y, Croll TI, Cai X, Dai A, He X, Duan J, Yin W, Ye C, Zhou F, Wu B, Zhao Q, Xu HE, Wang MW, Jiang Y | 10.1038/S41589-021-00841-3 | 2021-08-25 | Yes | |
| CCKAR | CCK1 | Cholecystokinin | A | Human | Cryo-EM | 7EZH | - | 3.2 | D | Active | 100 | 69 | Gi/o | αi1 | - | 61 | - | scFv16 |
CCK-8
|
peptide | Agonist | CCK-39, gastrin-17, desulfated cholecystokinin-8, CCK-4, CCK-58, CCK-8, CCK-33 | peptide | No | No | Liu Q, Yang D, Zhuang Y, Croll TI, Cai X, Dai A, He X, Duan J, Yin W, Ye C, Zhou F, Wu B, Zhao Q, Xu HE, Wang MW, Jiang Y | 10.1038/S41589-021-00841-3 | 2021-08-25 | Yes | |
| CCKAR | CCK1 | Cholecystokinin | A | Human | Cryo-EM | 7EZM | - | 2.9 | D | Active | 100 | 71 | Gq/11 | αq | - | 63 | - | scFv16 |
CCK-8
|
peptide | Agonist | CCK-39, gastrin-17, desulfated cholecystokinin-8, CCK-4, CCK-58, CCK-8, CCK-33 | peptide | No | No | Liu Q, Yang D, Zhuang Y, Croll TI, Cai X, Dai A, He X, Duan J, Yin W, Ye C, Zhou F, Wu B, Zhao Q, Xu HE, Wang MW, Jiang Y | 10.1038/S41589-021-00841-3 | 2021-08-25 | Yes | |
| PD2R2 | DP2 | Prostanoid | A | Human | X-ray | 7M8W | 7M8W_refined | 2.6 | A | Inactive | 21 | 83 | - | - | - | - | T4-Lysozyme | - |
15(R)-15-methyl-PGD2
|
small-molecule | Antagonist | PGD3, PGF2α, PGI2, PGJ2, PGE2, thromboxane A2, PGD2 | small-molecule | No | No | Liu H, Deepak RNVK, Shiriaeva A, Gati C, Batyuk A, Hu H, Weierstall U, Liu W, Wang L, Cherezov V, Fan H, Zhang C | 10.1073/PNAS.2102813118 | 2021-08-25 | Yes | |
| GHSR | ghrelin | Ghrelin | A | Human | Cryo-EM | 7F9Y | - | 2.9 | R | Active | 100 | 78 | Gq/11 | αq | Engineered G alpha | 59 | - | Nanobody-35 |
ghrelin
|
peptide | Agonist | [des-Gln14]ghrelin, ghrelin | peptide | No | No | Wang Y, Guo S, Zhuang Y, Yun Y, Xu P, He X, Guo J, Yin W, Xu HE, Xie X, Jiang Y | 10.1038/S41467-021-25364-2 | 2021-08-18 | Yes | |
| GHSR | ghrelin | Ghrelin | A | Human | Cryo-EM | 7F9Z | 7F9Z_refined | 3.2 | R | Active | 100 | 77 | Gq/11 | αq | Engineered G alpha | 59 | - | Nanobody-35 scFv16 |
GHRP-6
|
peptide | Agonist | [des-Gln14]ghrelin, ghrelin | peptide | No | No | Wang Y, Guo S, Zhuang Y, Yun Y, Xu P, He X, Guo J, Yin W, Xu HE, Xie X, Jiang Y | 10.1038/S41467-021-25364-2 | 2021-08-18 | Yes | |
| MTR1A | MT1 | Melatonin | A | Human | Cryo-EM | 7DB6 | 7DB6_refined | 3.3 | D | Active | 100 | 79 | Gi/o | αi1 | - | 62 | - | scFv16 |
ramelteon
|
small-molecule | Agonist | melatonin | small-molecule | No | No | Okamoto HH, Miyauchi H, Inoue A, Raimondi F, Tsujimoto H, Kusakizako T, Shihoya W, Yamashita K, Suno R, Nomura N, Kobayashi T, Iwata S, Nishizawa T, Nureki O | 10.1038/S41594-021-00634-1 | 2021-08-18 | Yes | |
| PTH2R | PTH2 | Parathyroid hormone | B1 | Human | Cryo-EM | 7F16 | - | 2.8 | R | Active | 100 | 68 | Gs | αs | - | 58 | - | Nanobody-35 |
TIP39
|
peptide | Agonist | PTHrP-(1-34) (human), PTH, TIP39, PTHrP, PTHrP-(1-36) | peptide | No | No | Wang X, Cheng X, Zhao L, Wang Y, Ye C, Zou X, Dai A, Cong Z, Chen J, Zhou Q, Xia T, Jiang H, Xu HE, Yang D, Wang MW | 10.1073/PNAS.2101279118 | 2021-08-18 | Yes | |
| GLP1R | GLP-1 | Glucagon | B1 | Human | Cryo-EM | 7DUR | - | 3.3 | R | Active | 100 | 80 | Gs | αs | - | 60 | - | Nanobody-35 |
N-Tert-butyl-6,7-dichloroquinoxalin-2-amine
|
small-molecule | Ago-PAM | glucagon-like peptide 1-(7-36) amide, glucagon, glucagon-like peptide 1-(7-37) | peptide | No | No | Cong Z, Chen LN, Ma H, Zhou Q, Zou X, Ye C, Dai A, Liu Q, Huang W, Sun X, Wang X, Xu P, Zhao L, Xia T, Zhong W, Yang D, Eric Xu H, Zhang Y, Wang MW | 10.1038/S41467-021-24058-Z | 2021-08-11 | Yes | |
| GLP1R | GLP-1 | Glucagon | B1 | Human | Cryo-EM | 7EVM | - | 2.5 | R | Active | 100 | 61 | Gs | αs | - | 60 | - | Nanobody-35 |
N-Tert-butyl-6,7-dichloroquinoxalin-2-amine
|
small-molecule | Ago-PAM | glucagon-like peptide 1-(7-36) amide, glucagon, glucagon-like peptide 1-(7-37) | peptide | No | No | Cong Z, Chen LN, Ma H, Zhou Q, Zou X, Ye C, Dai A, Liu Q, Huang W, Sun X, Wang X, Xu P, Zhao L, Xia T, Zhong W, Yang D, Eric Xu H, Zhang Y, Wang MW | 10.1038/S41467-021-24058-Z | 2021-08-11 | Yes | |
| 5HT1F | 5-HT1F | 5-Hydroxytryptamine | A | Human | Cryo-EM | 7EXD | 7EXD_refined | 3.4 | R | Active | 100 | 74 | Gi/o | αi1 | - | 62 | BRIL | scFv16 |
lasmiditan
|
small-molecule | Agonist | 5-hydroxytryptamine | small-molecule | No | No | Huang S, Xu P, Tan Y, You C, Zhang Y, Jiang Y, Xu HE | 10.1038/S41422-021-00527-4 | 2021-08-04 | Yes | |
| ADRB3 | β3 | Adrenoceptors | A | Dog | Cryo-EM | 7DH5 | - | 3.2 | R | Active | 100 | 68 | Gs | αs | - | 59 | - | Nanobody-35 |
mirabegron
|
small-molecule | Agonist | - | - | No | No | Nagiri C, Kobayashi K, Tomita A, Kato M, Kobayashi K, Yamashita K, Nishizawa T, Inoue A, Shihoya W, Nureki O | 10.1016/J.MOLCEL.2021.06.024 | 2021-08-04 | Yes | |
| FZD7 | FZD7 | Frizzled | F | Human | Cryo-EM | 7EVW | - | 3.2 | R | Active | 100 | 59 | Gs | αs | - | 59 | - | Nanobody-35 |
Apo (no ligand)
|
none | Apo (no ligand) | - | - | No | No | Xu L, Chen B, Schihada H, Wright SC, Turku A, Wu Y, Han GW, Kowalski-Jahn M, Kozielewicz P, Bowin CF, Zhang X, Li C, Bouvier M, Schulte G, Xu F | 10.1038/S41422-021-00525-6 | 2021-08-04 | Yes | |
| GIPR | GIP | Glucagon | B1 | Human | Cryo-EM | 7DTY | - | 3.0 | R | Active | 100 | 79 | Gs | αs | - | 59 | - | Nanobody-35 |
GIP
|
small-molecule | Agonist | gastric inhibitory polypeptide | peptide | No | No | Zhao F, Zhang C, Zhou Q, Hang K, Zou X, Chen Y, Wu F, Rao Q, Dai A, Yin W, Shen DD, Zhang Y, Xia T, Stevens RC, Xu HE, Yang D, Zhao L, Wang MW | 10.7554/ELIFE.68719 | 2021-08-04 | Yes | |
| GLP1R | GLP-1 | Glucagon | B1 | Human | Cryo-EM | 7KI0 | - | 2.5 | R | Active | 100 | 83 | Gs | αs | - | 53 | - | Nanobody-35 |
semaglutide
|
peptide | Agonist | glucagon-like peptide 1-(7-36) amide, glucagon, glucagon-like peptide 1-(7-37) | peptide | No | No | Zhang X, Belousoff MJ, Liang YL, Danev R, Sexton PM, Wootten D | 10.1016/J.CELREP.2021.109374 | 2021-08-04 | Yes | |
| GLP1R | GLP-1 | Glucagon | B1 | Human | Cryo-EM | 7KI1 | - | 2.5 | R | Active | 100 | 83 | Gs | αs | - | 89 | - | Nanobody-35 |
taspoglutide
|
peptide | Agonist | glucagon-like peptide 1-(7-36) amide, glucagon, glucagon-like peptide 1-(7-37) | peptide | No | No | Zhang X, Belousoff MJ, Liang YL, Danev R, Sexton PM, Wootten D | 10.1016/J.CELREP.2021.109374 | 2021-08-04 | Yes | |
| V2R | V2 | Vasopressin and oxytocin | A | Human | Cryo-EM | 7DW9 | - | 2.6 | R | Active | 100 | 75 | Gs | αs | - | 60 | - | Nanobody-35 scFv16 |
vasopressin
|
peptide | Agonist | oxytocin, vasopressin | peptide | No | No | Zhou F, Ye C, Ma X, Yin W, Croll TI, Zhou Q, He X, Zhang X, Yang D, Wang P, Xu HE, Wang MW, Jiang Y | 10.1038/S41422-021-00480-2 | 2021-07-21 | Yes | |
| CCR5 | CCR5 | Chemokine | A | Human | Cryo-EM | 7F1S | 7F1S_refined | 2.8 | R | Active | 100 | 78 | Gi/o | αi1 | - | 61 | - | - |
Apo (no ligand)
|
none | Apo (no ligand) | CCL13, CCL11, CCL8, CCL2, CCL7, CCL4, CCL5, CCL14, CCL3, CCL16 | peptide | No | No | Zhang H, Chen K, Tan Q, Shao Q, Han S, Zhang C, Yi C, Chu X, Zhu Y, Xu Y, Zhao Q, Wu B | 10.1038/S41467-021-24438-5 | 2021-07-14 | Yes | |
| CCR5 | CCR5 | Chemokine | A | Human | X-ray | 7F1T | - | 2.6 | A | Inactive | 9 | 86 | - | - | - | - | Rubredoxin | - |
CCL3
|
peptide | Agonist | CCL13, CCL11, CCL8, CCL2, CCL7, CCL4, CCL5, CCL14, CCL3, CCL16 | peptide | No | No | - | - | 2021-07-14 | Yes | |
| CCR5 | CCR5 | Chemokine | A | Human | Cryo-EM | 7F1R | - | 3.0 | R | Active | 100 | 79 | Gi/o | αi1 | - | 61 | - | - |
CCL5
|
peptide | Agonist | CCL13, CCL11, CCL8, CCL2, CCL7, CCL4, CCL5, CCL14, CCL3, CCL16 | peptide | No | No | - | - | 2021-07-14 | Yes | |
| CCR5 | CCR5 | Chemokine | A | Human | Cryo-EM | 7F1Q | - | 2.9 | R | Active | 100 | 85 | Gi/o | αi1 | - | 61 | - | - |
CCL3
|
peptide | Agonist | CCL13, CCL11, CCL8, CCL2, CCL7, CCL4, CCL5, CCL14, CCL3, CCL16 | peptide | No | No | - | - | 2021-07-14 | Yes | |
| GLP1R | GLP-1 | Glucagon | B1 | Human | Cryo-EM | 7DUQ | - | 2.5 | R | Active | 100 | 83 | Gs | αs | - | 61 | - | Nanobody-35 |
N-Tert-butyl-6,7-dichloroquinoxalin-2-amine
CHEMBL410972 |
small-molecule protein |
Ago-PAM Agonist |
glucagon-like peptide 1-(7-36) amide, glucagon, glucagon-like peptide 1-(7-37) | peptide | No | No | Cong Z, Chen LN, Ma H, Zhou Q, Zou X, Ye C, Dai A, Liu Q, Huang W, Sun X, Wang X, Xu P, Zhao L, Xia T, Zhong W, Yang D, Eric Xu H, Zhang Y, Wang MW | 10.1038/S41467-021-24058-Z | 2021-07-14 | Yes | |
| GLP1R | GLP-1 | Glucagon | B1 | Human | Cryo-EM | 7E14 | - | 2.9 | R | Active | 100 | 81 | Gs | αs | - | 49 | - | Nanobody-35 |
N-Tert-butyl-6,7-dichloroquinoxalin-2-amine
orforglipron |
small-molecule small-molecule |
Ago-PAM Agonist |
glucagon-like peptide 1-(7-36) amide, glucagon, glucagon-like peptide 1-(7-37) | peptide | No | No | Cong Z, Chen LN, Ma H, Zhou Q, Zou X, Ye C, Dai A, Liu Q, Huang W, Sun X, Wang X, Xu P, Zhao L, Xia T, Zhong W, Yang D, Eric Xu H, Zhang Y, Wang MW | 10.1038/S41467-021-24058-Z | 2021-07-07 | Yes | |
| GRM2 | mGlu2 | Metabotropic glutamate | C | Human | Cryo-EM | 7MTQ | - | 3.7 | B | Inactive | - | 85 | - | - | - | - | - | - |
LY341495
|
small-molecule | Antagonist | L-glutamic acid | small-molecule | No | No | Seven AB, Barros-Alvarez X, de Lapeyriere M, Papasergi-Scott MM, Robertson MJ, Zhang C, Nwokonko RM, Gao Y, Meyerowitz JG, Rocher JP, Schelshorn D, Kobilka BK, Mathiesen JM, Skiniotis G | 10.1038/S41586-021-03680-3 | 2021-07-07 | Yes | |
| GRM2 | mGlu2 | Metabotropic glutamate | C | Human | Cryo-EM | 7MTS | - | 3.2 | A | Active | - | 90 | Gi/o | αi1 | - | 58 | - | - |
2-methoxy-6-propyl-N-(2-{4-[(1H-tetrazol-5-yl)methoxy]phenyl}ethyl)thieno[2,3-d]pyrimidin-4-amine
L-glutamic acid |
small-molecule small-molecule |
Ago-PAM Agonist |
L-glutamic acid | small-molecule | No | No | Seven AB, Barros-Alvarez X, de Lapeyriere M, Papasergi-Scott MM, Robertson MJ, Zhang C, Nwokonko RM, Gao Y, Meyerowitz JG, Rocher JP, Schelshorn D, Kobilka BK, Mathiesen JM, Skiniotis G | 10.1038/S41586-021-03680-3 | 2021-07-07 | Yes | |
| GRM2 | mGlu2 | Metabotropic glutamate | C | Human | Cryo-EM | 7MTR | 7MTR_refined | 3.3 | A | Active | - | 88 | - | - | - | - | - | - |
2-methoxy-6-propyl-N-(2-{4-[(1H-tetrazol-5-yl)methoxy]phenyl}ethyl)thieno[2,3-d]pyrimidin-4-amine
L-glutamic acid |
small-molecule small-molecule |
Ago-PAM Agonist |
L-glutamic acid | small-molecule | No | No | Seven AB, Barros-Alvarez X, de Lapeyriere M, Papasergi-Scott MM, Robertson MJ, Zhang C, Nwokonko RM, Gao Y, Meyerowitz JG, Rocher JP, Schelshorn D, Kobilka BK, Mathiesen JM, Skiniotis G | 10.1038/S41586-021-03680-3 | 2021-07-07 | Yes | |
| OPSD | Rhodopsin | Opsins | A | Bovine | Cryo-EM | 7MT9 | 7MT9_refined | 7.0 | R | Active | 97 | 93 | - | - | - | - | - | GRK1 |
Retinal (all-trans)
|
small-molecule | Agonist | - | - | No | No | Chen Q, Plasencia M, Li Z, Mukherjee S, Patra D, Chen CL, Klose T, Yao XQ, Kossiakoff AA, Chang L, Andrews PC, Tesmer JJG | 10.1038/S41586-021-03721-X | 2021-07-07 | Yes | |
| OPSD | Rhodopsin | Opsins | A | Bovine | Cryo-EM | 7MT8 | 7MT8_refined | 5.8 | R | Active | 97 | 93 | - | - | - | - | - | GRK1 |
Retinal (all-trans)
|
small-molecule | Agonist | - | - | No | No | Chen Q, Plasencia M, Li Z, Mukherjee S, Patra D, Chen CL, Klose T, Yao XQ, Kossiakoff AA, Chang L, Andrews PC, Tesmer JJG | 10.1038/S41586-021-03721-X | 2021-07-07 | Yes | |
| OPSD | Rhodopsin | Opsins | A | Bovine | Cryo-EM | 7MTB | 7MTB_refined | 4.0 | R | Active | 97 | 93 | - | - | - | - | - | Fab light chain Fab heavy chain GRK1 |
Retinal (all-trans)
|
small-molecule | Agonist | - | - | No | No | Chen Q, Plasencia M, Li Z, Mukherjee S, Patra D, Chen CL, Klose T, Yao XQ, Kossiakoff AA, Chang L, Andrews PC, Tesmer JJG | 10.1038/S41586-021-03721-X | 2021-07-07 | Yes | |
| OPSD | Rhodopsin | Opsins | A | Bovine | Cryo-EM | 7MTA | 7MTA_refined | 4.1 | R | Active | 97 | 93 | - | - | - | - | - | Fab heavy chain Fab light chain GRK1 |
Retinal (all-trans)
|
small-molecule | Agonist | - | - | No | No | Chen Q, Plasencia M, Li Z, Mukherjee S, Patra D, Chen CL, Klose T, Yao XQ, Kossiakoff AA, Chang L, Andrews PC, Tesmer JJG | 10.1038/S41586-021-03721-X | 2021-07-07 | Yes | |
| Q3KSP2 | BILF1 | Unclassified | A | strain GD1 | Cryo-EM | 7JHJ | - | 3.2 | R | Active | 100 | 89 | Gi/o | αi1 | - | 62 | - | scFv16 |
Apo (no ligand)
|
none | Apo (no ligand) | - | - | No | No | Tsutsumi N, Qu Q, Mavri M, Baggesen MS, Maeda S, Waghray D, Berg C, Kobilka BK, Rosenkilde MM, Skiniotis G, Garcia KC | 10.1016/J.IMMUNI.2021.06.001 | 2021-07-07 | Yes | |
| CASR | CaS | Calcium-sensing | C | Human | Cryo-EM | 7M3G | 7M3G_refined | 2.5 | A | Active | - | 76 | - | - | - | - | - | - |
Calcium
evocalcet L-tryptophan |
small-molecule small-molecule small-molecule |
Agonist PAM PAM |
Mg2+, L-tryptophan, spermine, Ca2+ | small-molecule | No | No | Gao Y, Robertson MJ, Rahman SN, Seven AB, Zhang C, Meyerowitz JG, Panova O, Hannan FM, Thakker RV, Brauner-Osborne H, Mathiesen JM, Skiniotis G | 10.1038/S41586-021-03691-0 | 2021-06-30 | Yes | |
| CASR | CaS | Calcium-sensing | C | Human | Cryo-EM | 7M3J | 7M3J_refined | 4.1 | A | Inactive | - | 72 | - | - | - | - | - | - |
NPS 2143
|
small-molecule | NAM | Mg2+, L-tryptophan, spermine, Ca2+ | small-molecule | No | No | Gao Y, Robertson MJ, Rahman SN, Seven AB, Zhang C, Meyerowitz JG, Panova O, Hannan FM, Thakker RV, Brauner-Osborne H, Mathiesen JM, Skiniotis G | 10.1038/S41586-021-03691-0 | 2021-06-30 | Yes | |
| CASR | CaS | Calcium-sensing | C | Human | Cryo-EM | 7M3E | 7M3E_refined | 3.2 | B | Inactive | - | 75 | - | - | - | - | - | - |
Calcium
NPS 2143 L-tryptophan |
small-molecule small-molecule small-molecule |
Agonist NAM PAM |
Mg2+, L-tryptophan, spermine, Ca2+ | small-molecule | No | No | Gao Y, Robertson MJ, Rahman SN, Seven AB, Zhang C, Meyerowitz JG, Panova O, Hannan FM, Thakker RV, Brauner-Osborne H, Mathiesen JM, Skiniotis G | 10.1038/S41586-021-03691-0 | 2021-06-30 | Yes | |
| CASR | CaS | Calcium-sensing | C | Human | Cryo-EM | 7M3F | 7M3F_refined | 2.8 | B | Active | - | 75 | - | - | - | - | - | - |
Calcium
cinacalcet L-tryptophan |
small-molecule small-molecule small-molecule |
Agonist PAM PAM |
Mg2+, L-tryptophan, spermine, Ca2+ | small-molecule | No | No | Gao Y, Robertson MJ, Rahman SN, Seven AB, Zhang C, Meyerowitz JG, Panova O, Hannan FM, Thakker RV, Brauner-Osborne H, Mathiesen JM, Skiniotis G | 10.1038/S41586-021-03691-0 | 2021-06-30 | Yes | |
| CCR5 | CCR5 | Chemokine | A | Human | Cryo-EM | 7O7F | 7O7F_refined | 3.2 | C | Active | 100 | 85 | Gi/o | αi1 | - | 62 | - | Fab heavy chain Fab light chain |
CCL5
|
peptide | Agonist | CCL13, CCL11, CCL8, CCL2, CCL7, CCL4, CCL5, CCL14, CCL3, CCL16 | peptide | No | No | Isaikina P, Tsai CJ, Dietz N, Pamula F, Grahl A, Goldie KN, Guixa-Gonzalez R, Branco C, Paolini-Bertrand M, Calo N, Cerini F, Schertler GFX, Hartley O, Stahlberg H, Maier T, Deupi X, Grzesiek S | 10.1126/SCIADV.ABG8685 | 2021-06-30 | Yes | |
| GRM2 | mGlu2 | Metabotropic glutamate | C | Human | Cryo-EM | 7EPB | 7EPB_refined | 3.1 | B | Active | - | 89 | - | - | - | - | - | Anti-RON nanobody |
eglumegad
|
small-molecule | Agonist | L-glutamic acid | small-molecule | No | No | Du J, Wang D, Fan H, Xu C, Tai L, Lin S, Han S, Tan Q, Wang X, Xu T, Zhang H, Chu X, Yi C, Liu P, Wang X, Zhou Y, Pin JP, Rondard P, Liu H, Liu J, Sun F, Wu B, Zhao Q | 10.1038/S41586-021-03641-W | 2021-06-23 | Yes | |
| GRM2 | mGlu2 | Metabotropic glutamate | C | Human | X-ray | 7EPE | 7EPE_refined | 2.5 | A | Inactive | - | 28 | - | - | - | - | Flavodoxin | - |
CHEMBL3894759
|
small-molecule | NAM | L-glutamic acid | small-molecule | No | No | Du J, Wang D, Fan H, Xu C, Tai L, Lin S, Han S, Tan Q, Wang X, Xu T, Zhang H, Chu X, Yi C, Liu P, Wang X, Zhou Y, Pin JP, Rondard P, Liu H, Liu J, Sun F, Wu B, Zhao Q | 10.1038/S41586-021-03641-W | 2021-06-23 | Yes | |
| GRM2 | mGlu2 | Metabotropic glutamate | C | Human | Cryo-EM | 7EPD | 7EPD_refined | 3.9 | A | Inactive | - | 89 | - | - | - | - | - | - |
Apo (no ligand)
|
none | Apo (no ligand) | L-glutamic acid | small-molecule | No | No | Du J, Wang D, Fan H, Xu C, Tai L, Lin S, Han S, Tan Q, Wang X, Xu T, Zhang H, Chu X, Yi C, Liu P, Wang X, Zhou Y, Pin JP, Rondard P, Liu H, Liu J, Sun F, Wu B, Zhao Q | 10.1038/S41586-021-03641-W | 2021-06-23 | Yes | |
| GRM2 | mGlu2 | Metabotropic glutamate | C | Human | Cryo-EM | 7EPA | 7EPA_refined | 3.6 | A | Intermediate | - | 90 | - | - | - | - | - | - |
Apo (no ligand)
|
none | Apo (no ligand) | L-glutamic acid | small-molecule | No | No | Du J, Wang D, Fan H, Xu C, Tai L, Lin S, Han S, Tan Q, Wang X, Xu T, Zhang H, Chu X, Yi C, Liu P, Wang X, Zhou Y, Pin JP, Rondard P, Liu H, Liu J, Sun F, Wu B, Zhao Q | 10.1038/S41586-021-03641-W | 2021-06-23 | Yes | |
| GRM2 | mGlu2 | Metabotropic glutamate | C | Human | X-ray | 7EPF | 7EPF_refined | 2.7 | A | Inactive | - | 28 | - | - | - | - | Flavodoxin | - |
(8~{R})-4-[2,4-Bis(fluoranyl)phenyl]-8-methyl-7-[(2-methylpyrazol-3-yl)methyl]-6,8-dihydro-5~{H}-1,7-naphthyridine-2-carboxamide
|
small-molecule | NAM | L-glutamic acid | small-molecule | No | No | Du J, Wang D, Fan H, Xu C, Tai L, Lin S, Han S, Tan Q, Wang X, Xu T, Zhang H, Chu X, Yi C, Liu P, Wang X, Zhou Y, Pin JP, Rondard P, Liu H, Liu J, Sun F, Wu B, Zhao Q | 10.1038/S41586-021-03641-W | 2021-06-23 | Yes | |
| GRM2 | mGlu2 | Metabotropic glutamate | C | Human | Cryo-EM | 7E9G | - | 3.5 | R | Intermediate | - | 88 | Gi/o | αi1 | - | 63 | - | scFv16 |
eglumegad
JNJ-40411813 |
small-molecule small-molecule |
Agonist PAM |
L-glutamic acid | small-molecule | No | No | Lin S, Han S, Cai X, Tan Q, Zhou K, Wang D, Wang X, Du J, Yi C, Chu X, Dai A, Zhou Y, Chen Y, Zhou Y, Liu H, Liu J, Yang D, Wang MW, Zhao Q, Wu B | 10.1038/S41586-021-03495-2 | 2021-06-23 | Yes | |
| GRM4 | mGlu4 | Metabotropic glutamate | C | Human | Cryo-EM | 7E9H | - | 4.0 | R | Intermediate | - | 84 | Gi/o | αi3 | - | 63 | - | scFv16 |
L-serine-O-phosphate
|
small-molecule | Agonist | L-serine-O-phosphate, L-glutamic acid | small-molecule | No | No | Lin S, Han S, Cai X, Tan Q, Zhou K, Wang D, Wang X, Du J, Yi C, Chu X, Dai A, Zhou Y, Chen Y, Zhou Y, Liu H, Liu J, Yang D, Wang MW, Zhao Q, Wu B | 10.1038/S41586-021-03495-2 | 2021-06-23 | Yes | |
| GRM7 | mGlu7 | Metabotropic glutamate | C | Human | Cryo-EM | 7EPC | 7EPC_refined | 4.0 | B | Inactive | - | 85 | - | - | - | - | - | - |
Apo (no ligand)
|
none | Apo (no ligand) | L-serine-O-phosphate, L-glutamic acid | small-molecule | No | No | Du J, Wang D, Fan H, Xu C, Tai L, Lin S, Han S, Tan Q, Wang X, Xu T, Zhang H, Chu X, Yi C, Liu P, Wang X, Zhou Y, Pin JP, Rondard P, Liu H, Liu J, Sun F, Wu B, Zhao Q | 10.1038/S41586-021-03641-W | 2021-06-23 | Yes | |
| CASR | CaS | Calcium-sensing | C | Human | Cryo-EM | 7DD6 | - | 3.2 | B | Active | - | 73 | - | - | - | - | - | - |
Calcium
L-tryptophan |
small-molecule small-molecule |
Agonist PAM |
Mg2+, L-tryptophan, spermine, Ca2+ | small-molecule | No | No | Wen T, Wang Z, Chen X, Ren Y, Lu X, Xing Y, Lu J, Chang S, Zhang X, Shen Y, Yang X | 10.1126/SCIADV.ABG1483 | 2021-06-16 | Yes | |
| CASR | CaS | Calcium-sensing | C | Human | Cryo-EM | 7DD7 | - | 3.2 | B | Active | - | 73 | - | - | - | - | - | - |
Calcium
evocalcet L-tryptophan |
small-molecule small-molecule small-molecule |
Agonist PAM PAM |
Mg2+, L-tryptophan, spermine, Ca2+ | small-molecule | No | No | Wen T, Wang Z, Chen X, Ren Y, Lu X, Xing Y, Lu J, Chang S, Zhang X, Shen Y, Yang X | 10.1126/SCIADV.ABG1483 | 2021-06-16 | Yes | |
| CASR | CaS | Calcium-sensing | C | Human | Cryo-EM | 7DD5 | - | 3.2 | A | Inactive | - | 74 | - | - | - | - | - | - |
Calcium
NPS 2143 L-tryptophan |
small-molecule small-molecule small-molecule |
Agonist NAM PAM |
Mg2+, L-tryptophan, spermine, Ca2+ | small-molecule | No | No | Wen T, Wang Z, Chen X, Ren Y, Lu X, Xing Y, Lu J, Chang S, Zhang X, Shen Y, Yang X | 10.1126/SCIADV.ABG1483 | 2021-06-16 | Yes | |
| S1PR3 | S1P3 | Lysophospholipid (S1P) | A | Human | X-ray | 7C4S | 7C4S_refined | 3.2 | A | Active | 59 | 75 | - | - | - | - | - | Fab light chain Fab heavy chain |
sphingosine 1-phosphate
|
small-molecule | Agonist | dihydrosphingosine 1-phosphate, sphingosylphosphorylcholine, sphingosine 1-phosphate | small-molecule | No | No | Maeda S, Shiimura Y, Asada H, Hirata K, Luo F, Nango E, Tanaka N, Toyomoto M, Inoue A, Aoki J, Iwata S, Hagiwara M | 10.1126/SCIADV.ABF5325 | 2021-06-09 | Yes | |
| V2R | V2 | Vasopressin and oxytocin | A | Human | Cryo-EM | 7BB6 | - | 4.2 | A | Active | 100 | 73 | Gs | αs | - | 54 | - | Nanobody-35 |
vasopressin
|
peptide | Agonist | oxytocin, vasopressin | peptide | No | No | Bous J, Orcel H, Floquet N, Leyrat C, Lai-Kee-Him J, Gaibelet G, Ancelin A, Saint-Paul J, Trapani S, Louet M, Sounier R, Demene H, Granier S, Bron P, Mouillac B | 10.1126/SCIADV.ABG5628 | 2021-06-02 | Yes | |
| V2R | V2 | Vasopressin and oxytocin | A | Human | Cryo-EM | 7BB7 | - | 4.4 | A | Active | 100 | 72 | Gs | αs | - | 55 | - | Nanobody-35 |
vasopressin
|
peptide | Agonist | oxytocin, vasopressin | peptide | No | No | Bous J, Orcel H, Floquet N, Leyrat C, Lai-Kee-Him J, Gaibelet G, Ancelin A, Saint-Paul J, Trapani S, Louet M, Sounier R, Demene H, Granier S, Bron P, Mouillac B | 10.1126/SCIADV.ABG5628 | 2021-06-02 | Yes | |
| CCKAR | CCK1 | Cholecystokinin | A | Human | Cryo-EM | 7MBY | - | 2.4 | R | Active | 100 | 66 | Gq/11 | αq | Gq-Gs-Gi1 chimera | 55 | - | - |
CHEMBL216166
|
protein | Agonist | CCK-39, gastrin-17, desulfated cholecystokinin-8, CCK-4, CCK-58, CCK-8, CCK-33 | peptide | No | No | Mobbs JI, Belousoff MJ, Harikumar KG, Piper SJ, Xu X, Furness SGB, Venugopal H, Christopoulos A, Danev R, Wootten D, Thal DM, Miller LJ, Sexton PM | 10.1371/JOURNAL.PBIO.3001295 | 2021-05-26 | Yes | |
| CCKAR | CCK1 | Cholecystokinin | A | Human | Cryo-EM | 7MBX | - | 2.0 | R | Active | 100 | 68 | Gs | αs | - | 61 | - | Nanobody-35 |
CHEMBL216166
|
protein | Agonist | CCK-39, gastrin-17, desulfated cholecystokinin-8, CCK-4, CCK-58, CCK-8, CCK-33 | peptide | No | No | Mobbs JI, Belousoff MJ, Harikumar KG, Piper SJ, Xu X, Furness SGB, Venugopal H, Christopoulos A, Danev R, Wootten D, Thal DM, Miller LJ, Sexton PM | 10.1371/JOURNAL.PBIO.3001295 | 2021-05-26 | Yes | |
| V2R | V2 | Vasopressin and oxytocin | A | Human | Cryo-EM | 7KH0 | - | 2.8 | R | Active | 100 | 74 | Gs | αs | - | 58 | - | scFv16 Nanobody-35 |
vasopressin
|
peptide | Agonist | oxytocin, vasopressin | peptide | No | No | Wang L, Xu J, Cao S, Sun D, Liu H, Lu Q, Liu Z, Du Y, Zhang C | 10.1038/S41422-021-00483-Z | 2021-05-26 | Yes | |
| GABR2 | GABAB2 | GABAB | C | Human | Cryo-EM | 7EB2 | - | 3.5 | D | Active | - | 72 | Gi/o | αi1 | - | 99 | - | scFv16 |
(-)-baclofen
BHFF |
small-molecule small-molecule |
Agonist PAM |
- | - | No | No | Shen C, Mao C, Xu C, Jin N, Zhang H, Shen DD, Shen Q, Wang X, Hou T, Chen Z, Rondard P, Pin JP, Zhang Y, Liu J | 10.1038/S41586-021-03507-1 | 2021-05-05 | Yes | |
| PE2R2 | EP2 | Prostanoid | A | Human | Cryo-EM | 7CX3 | - | 2.8 | R | Active | 100 | 74 | Gs | αs | - | 58 | - | Nanobody-35 |
taprenepag
|
small-molecule | Agonist | PGE1, PGF2α, PGI2, PGE2, thromboxane A2, PGD2 | small-molecule | No | No | Qu C, Mao C, Xiao P, Shen Q, Zhong YN, Yang F, Shen DD, Tao X, Zhang H, Yan X, Zhao RJ, He J, Guan Y, Zhang C, Hou G, Zhang PJ, Hou G, Li Z, Yu X, Chai RJ, Guan YF, Sun JP, Zhang Y | 10.1126/SCIADV.ABF1268 | 2021-05-05 | Yes | |
| PE2R2 | EP2 | Prostanoid | A | Human | Cryo-EM | 7CX2 | - | 2.8 | R | Active | 100 | 74 | Gs | αs | - | 58 | - | Nanobody-35 |
PGE2
|
small-molecule | Agonist | PGE1, PGF2α, PGI2, PGE2, thromboxane A2, PGD2 | small-molecule | No | No | Qu C, Mao C, Xiao P, Shen Q, Zhong YN, Yang F, Shen DD, Tao X, Zhang H, Yan X, Zhao RJ, He J, Guan Y, Zhang C, Hou G, Zhang PJ, Hou G, Li Z, Yu X, Chai RJ, Guan YF, Sun JP, Zhang Y | 10.1126/SCIADV.ABF1268 | 2021-05-05 | Yes | |
| PE2R2 | EP2 | Prostanoid | A | Human | Cryo-EM | 7CX4 | 7CX4_refined | 2.9 | R | Active | 100 | 74 | Gs | αs | - | 58 | - | Nanobody-35 |
evatanepag
|
small-molecule | Agonist | PGE1, PGF2α, PGI2, PGE2, thromboxane A2, PGD2 | small-molecule | No | No | Qu C, Mao C, Xiao P, Shen Q, Zhong YN, Yang F, Shen DD, Tao X, Zhang H, Yan X, Zhao RJ, He J, Guan Y, Zhang C, Hou G, Zhang PJ, Hou G, Li Z, Yu X, Chai RJ, Guan YF, Sun JP, Zhang Y | 10.1126/SCIADV.ABF1268 | 2021-05-05 | Yes | |
| MC4R | MC4 | Melanocortin | A | Human | Cryo-EM | 7AUE | 7AUE_refined | 3.0 | R | Active | 100 | 79 | Gs | αs | - | 59 | - | scFv16 |
setmelanotide
|
peptide | Agonist | γ-MSH, α-MSH, β-MSH, ACTH, agouti-related protein | peptide | No | No | Israeli H, Degtjarik O, Fierro F, Chunilal V, Gill AK, Roth NJ, Botta J, Prabahar V, Peleg Y, Chan LF, Ben-Zvi D, McCormick PJ, Niv MY, Shalev-Benami M | 10.1126/SCIENCE.ABF7958 | 2021-04-28 | Yes | |
| 5HT1D | 5-HT1D | 5-Hydroxytryptamine | A | Human | Cryo-EM | 7E32 | - | 2.9 | R | Active | 100 | 76 | Gi/o | αi1 | - | 62 | - | scFv16 |
5-hydroxytryptamine
|
small-molecule | Agonist | 5-HT-moduline, 5-hydroxytryptamine | small-molecule | No | No | Xu P, Huang S, Zhang H, Mao C, Zhou XE, Cheng X, Simon IA, Shen DD, Yen HY, Robinson CV, Harpsoe K, Svensson B, Guo J, Jiang H, Gloriam DE, Melcher K, Jiang Y, Zhang Y, Xu HE | 10.1038/S41586-021-03376-8 | 2021-04-21 | Yes | |
| 5HT1A | 5-HT1A | 5-Hydroxytryptamine | A | Human | Cryo-EM | 7E2Z | - | 3.1 | R | Active | 100 | 66 | Gi/o | αi1 | - | 62 | - | - |
aripiprazole
|
small-molecule | Agonist (partial) | 5-hydroxytryptamine | small-molecule | No | No | Xu P, Huang S, Zhang H, Mao C, Zhou XE, Cheng X, Simon IA, Shen DD, Yen HY, Robinson CV, Harpsoe K, Svensson B, Guo J, Jiang H, Gloriam DE, Melcher K, Jiang Y, Zhang Y, Xu HE | 10.1038/S41586-021-03376-8 | 2021-04-14 | Yes | |
| 5HT1A | 5-HT1A | 5-Hydroxytryptamine | A | Human | Cryo-EM | 7E2Y | - | 3.0 | R | Active | 100 | 65 | Gi/o | αi1 | - | 62 | - | - |
5-hydroxytryptamine
|
small-molecule | Agonist | 5-hydroxytryptamine | small-molecule | No | No | Xu P, Huang S, Zhang H, Mao C, Zhou XE, Cheng X, Simon IA, Shen DD, Yen HY, Robinson CV, Harpsoe K, Svensson B, Guo J, Jiang H, Gloriam DE, Melcher K, Jiang Y, Zhang Y, Xu HE | 10.1038/S41586-021-03376-8 | 2021-04-14 | Yes | |
| 5HT1A | 5-HT1A | 5-Hydroxytryptamine | A | Human | Cryo-EM | 7E2X | - | 3.0 | R | Active | 100 | 66 | Gi/o | αi1 | - | 62 | - | - |
Apo (no ligand)
|
none | Apo (no ligand) | 5-hydroxytryptamine | small-molecule | No | No | Xu P, Huang S, Zhang H, Mao C, Zhou XE, Cheng X, Simon IA, Shen DD, Yen HY, Robinson CV, Harpsoe K, Svensson B, Guo J, Jiang H, Gloriam DE, Melcher K, Jiang Y, Zhang Y, Xu HE | 10.1038/S41586-021-03376-8 | 2021-04-14 | Yes | |
| 5HT1E | 5-HT1E | 5-Hydroxytryptamine | A | Human | Cryo-EM | 7E33 | 7E33_refined | 2.9 | R | Active | 100 | 70 | Gi/o | αi1 | - | 61 | - | scFv16 |
BRL-54443
|
small-molecule | Agonist | tryptamine, 5-hydroxytryptamine | small-molecule | No | No | Xu P, Huang S, Zhang H, Mao C, Zhou XE, Cheng X, Simon IA, Shen DD, Yen HY, Robinson CV, Harpsoe K, Svensson B, Guo J, Jiang H, Gloriam DE, Melcher K, Jiang Y, Zhang Y, Xu HE | 10.1038/S41586-021-03376-8 | 2021-04-14 | Yes | |
| DRD1 | D1 | Dopamine | A | Human | X-ray | 7JOZ | 7JOZ_refined | 3.8 | R | Active | 100 | 64 | Gs | αs | - | 86 | - | Nanobody-35 |
CHEMBL4453318
|
small-molecule | Agonist | noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, dopamine, 5-hydroxytryptamine | small-molecule | No | No | Sun B, Feng D, Chu ML, Fish I, Lovera S, Sands ZA, Kelm S, Valade A, Wood M, Ceska T, Kobilka TS, Lebon F, Kobilka BK | 10.1038/S41467-021-23519-9 | 2021-04-14 | Yes | |
| AA2AR | A2A | Adenosine | A | Human | X-ray | 7ARO | 7ARO_refined | 3.1 | A | Inactive | 1 | 72 | - | - | - | - | BRIL | - |
CHEMBL124345
|
small-molecule | Agonist (partial) | adenosine | small-molecule | No | No | Amelia T, van Veldhoven JPD, Falsini M, Liu R, Heitman LH, van Westen GJP, Segala E, Verdon G, Cheng RKY, Cooke RM, van der Es D, IJzerman AP. | 10.1021/acs.jmedchem.0c01856 | 2021-04-07 | Yes | |
| HRH1 | H1 | Histamine | A | Human | Cryo-EM | 7DFL | - | 3.3 | R | Active | 100 | 56 | Gq/11 | αq | - | 63 | - | scFv16 |
histamine
|
small-molecule | Agonist | histamine | small-molecule | No | No | Xia R, Wang N, Xu Z, Lu Y, Song J, Zhang A, Guo C, He Y | 10.1038/S41467-021-22427-2 | 2021-03-31 | Yes | |
| CASR | CaS | Calcium-sensing | C | Human | Cryo-EM | 7DTW | 7DTW_refined | 4.5 | A | Inactive | - | 72 | - | - | - | - | - | - |
Apo (no ligand)
|
none | Apo (no ligand) | Mg2+, L-tryptophan, spermine, Ca2+ | small-molecule | No | No | Ling S, Shi P, Liu S, Meng X, Zhou Y, Sun W, Chang S, Zhang X, Zhang L, Shi C, Sun D, Liu L, Tian C | 10.1038/S41422-021-00474-0 | 2021-03-10 | Yes | |
| CASR | CaS | Calcium-sensing | C | Human | Cryo-EM | 7DTT | 7DTT_refined | 3.8 | A | Active | - | 72 | - | - | - | - | - | - |
Calcium
|
small-molecule | Agonist | Mg2+, L-tryptophan, spermine, Ca2+ | small-molecule | No | No | Ling S, Shi P, Liu S, Meng X, Zhou Y, Sun W, Chang S, Zhang X, Zhang L, Shi C, Sun D, Liu L, Tian C | 10.1038/S41422-021-00474-0 | 2021-03-10 | Yes | |
| CASR | CaS | Calcium-sensing | C | Human | Cryo-EM | 7DTV | 7DTV_refined | 3.5 | A | Active | - | 72 | - | - | - | - | - | - |
Calcium
L-tryptophan |
small-molecule small-molecule |
Agonist PAM |
Mg2+, L-tryptophan, spermine, Ca2+ | small-molecule | No | No | Ling S, Shi P, Liu S, Meng X, Zhou Y, Sun W, Chang S, Zhang X, Zhang L, Shi C, Sun D, Liu L, Tian C | 10.1038/S41422-021-00474-0 | 2021-03-10 | Yes | |
| CASR | CaS | Calcium-sensing | C | Human | Cryo-EM | 7DTU | 7DTU_refined | 4.4 | A | Intermediate | - | 72 | - | - | - | - | - | - |
L-tryptophan
|
small-molecule | PAM | Mg2+, L-tryptophan, spermine, Ca2+ | small-molecule | No | No | Ling S, Shi P, Liu S, Meng X, Zhou Y, Sun W, Chang S, Zhang X, Zhang L, Shi C, Sun D, Liu L, Tian C | 10.1038/S41422-021-00474-0 | 2021-03-10 | Yes | |
| DRD3 | D3 | Dopamine | A | Human | Cryo-EM | 7CMV | - | 2.7 | R | Active | 100 | 68 | Gi/o | αi1 | - | 64 | BRIL | scFv16 |
CHEMBL70565
|
small-molecule | Agonist | dopamine | small-molecule | No | No | Xu P, Huang S, Mao C, Krumm BE, Zhou XE, Tan Y, Huang XP, Liu Y, Shen DD, Jiang Y, Yu X, Jiang H, Melcher K, Roth BL, Cheng X, Zhang Y, Xu HE | 10.1016/J.MOLCEL.2021.01.003 | 2021-03-10 | Yes | |
| DRD3 | D3 | Dopamine | A | Human | Cryo-EM | 7CMU | - | 3.0 | R | Active | 100 | 68 | Gi/o | αi1 | - | 64 | BRIL | scFv16 |
pramipexole
|
small-molecule | Agonist | dopamine | small-molecule | No | No | Xu P, Huang S, Mao C, Krumm BE, Zhou XE, Tan Y, Huang XP, Liu Y, Shen DD, Jiang Y, Yu X, Jiang H, Melcher K, Roth BL, Cheng X, Zhang Y, Xu HE | 10.1016/J.MOLCEL.2021.01.003 | 2021-03-10 | Yes | |
| DRD1 | D1 | Dopamine | A | Human | Cryo-EM | 7LJC | - | 3.0 | R | Active | 100 | 63 | Gs | αs | Engineered G alpha | 60 | - | Nanobody-35 |
CHEMBL1160787
mevidalen |
small-molecule small-molecule |
Agonist PAM |
noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, dopamine, 5-hydroxytryptamine | small-molecule | No | No | Zhuang Y, Krumm B, Zhang H, Zhou XE, Wang Y, Huang XP, Liu Y, Cheng X, Jiang Y, Jiang H, Zhang C, Yi W, Roth BL, Zhang Y, Xu HE | 10.1038/S41422-021-00482-0 | 2021-03-03 | Yes | |
| DRD1 | D1 | Dopamine | A | Human | Cryo-EM | 7CKY | - | 3.2 | R | Active | 100 | 62 | Gs | αs | - | 60 | - | Nanobody-35 |
CHEMBL3697578
|
small-molecule | Agonist | noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, dopamine, 5-hydroxytryptamine | small-molecule | No | No | Xiao P, Yan W, Gou L, Zhong YN, Kong L, Wu C, Wen X, Yuan Y, Cao S, Qu C, Yang X, Yang CC, Xia A, Hu Z, Zhang Q, He YH, Zhang DL, Zhang C, Hou GH, Liu H, Zhu L, Fu P, Yang S, Rosenbaum DM, Sun JP, Du Y, Zhang L, Yu X, Shao Z | 10.1016/J.CELL.2021.01.028 | 2021-03-03 | Yes | |
| DRD1 | D1 | Dopamine | A | Human | Cryo-EM | 7CKZ | - | 3.1 | R | Active | 100 | 62 | Gs | αs | - | 60 | - | Nanobody-35 |
dopamine
mevidalen |
small-molecule small-molecule |
Agonist PAM |
noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, dopamine, 5-hydroxytryptamine | small-molecule | No | No | Xiao P, Yan W, Gou L, Zhong YN, Kong L, Wu C, Wen X, Yuan Y, Cao S, Qu C, Yang X, Yang CC, Xia A, Hu Z, Zhang Q, He YH, Zhang DL, Zhang C, Hou GH, Liu H, Zhu L, Fu P, Yang S, Rosenbaum DM, Sun JP, Du Y, Zhang L, Yu X, Shao Z | 10.1016/J.CELL.2021.01.028 | 2021-03-03 | Yes | |
| DRD1 | D1 | Dopamine | A | Human | Cryo-EM | 7CKX | - | 3.5 | R | Active | 100 | 61 | Gs | αs | - | 60 | - | Nanobody-35 |
A77636
|
small-molecule | Agonist | noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, dopamine, 5-hydroxytryptamine | small-molecule | No | No | Xiao P, Yan W, Gou L, Zhong YN, Kong L, Wu C, Wen X, Yuan Y, Cao S, Qu C, Yang X, Yang CC, Xia A, Hu Z, Zhang Q, He YH, Zhang DL, Zhang C, Hou GH, Liu H, Zhu L, Fu P, Yang S, Rosenbaum DM, Sun JP, Du Y, Zhang L, Yu X, Shao Z | 10.1016/J.CELL.2021.01.028 | 2021-03-03 | Yes | |
| DRD1 | D1 | Dopamine | A | Human | Cryo-EM | 7CKW | 7CKW_refined | 3.2 | R | Active | 100 | 61 | Gs | αs | - | 60 | - | Nanobody-35 |
fenoldopam
|
small-molecule | Agonist | noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, dopamine, 5-hydroxytryptamine | small-molecule | No | No | Xiao P, Yan W, Gou L, Zhong YN, Kong L, Wu C, Wen X, Yuan Y, Cao S, Qu C, Yang X, Yang CC, Xia A, Hu Z, Zhang Q, He YH, Zhang DL, Zhang C, Hou GH, Liu H, Zhu L, Fu P, Yang S, Rosenbaum DM, Sun JP, Du Y, Zhang L, Yu X, Shao Z | 10.1016/J.CELL.2021.01.028 | 2021-03-03 | Yes | |
| DRD1 | D1 | Dopamine | A | Human | Cryo-EM | 7LJD | - | 3.2 | R | Active | 100 | 64 | Gs | αs | Engineered G alpha | 60 | - | Nanobody-35 |
dopamine
mevidalen |
small-molecule small-molecule |
Agonist PAM |
noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, dopamine, 5-hydroxytryptamine | small-molecule | No | No | - | - | 2021-03-03 | Yes | |
| DRD1 | D1 | Dopamine | A | Human | Cryo-EM | 7CRH | 7CRH_refined | 3.3 | R | Active | 100 | 61 | Gs | αs | - | 60 | - | Nanobody-35 |
CHEMBL1416789
|
small-molecule | Agonist | noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, dopamine, 5-hydroxytryptamine | small-molecule | No | No | Xiao P, Yan W, Gou L, Zhong YN, Kong L, Wu C, Wen X, Yuan Y, Cao S, Qu C, Yang X, Yang CC, Xia A, Hu Z, Zhang Q, He YH, Zhang DL, Zhang C, Hou GH, Liu H, Zhu L, Fu P, Yang S, Rosenbaum DM, Sun JP, Du Y, Zhang L, Yu X, Shao Z | 10.1016/J.CELL.2021.01.028 | 2021-03-03 | Yes | |
| CALRL | calcitonin-like | Calcitonin | B1 | Human | Cryo-EM | 7KNU | 7KNU_refined | 3.5 | R | Inactive | 9 | 74 | - | - | - | - | - | RAMP1 |
Calcitonin gene-related peptide 1
|
peptide | Agonist | - | - | No | No | Josephs TM, Belousoff MJ, Liang YL, Piper SJ, Cao J, Garama DJ, Leach K, Gregory KJ, Christopoulos A, Hay DL, Danev R, Wootten D, Sexton PM | 10.1126/SCIENCE.ABF7258 | 2021-02-24 | Yes | |
| CALRL | calcitonin-like | Calcitonin | B1 | Human | Cryo-EM | 7KNT | 7KNT_refined | 3.2 | R | Inactive | 9 | 74 | - | - | - | - | - | RAMP1 |
Apo (no ligand)
|
none | Apo (no ligand) | - | - | No | No | Josephs TM, Belousoff MJ, Liang YL, Piper SJ, Cao J, Garama DJ, Leach K, Gregory KJ, Christopoulos A, Hay DL, Danev R, Wootten D, Sexton PM | 10.1126/SCIENCE.ABF7258 | 2021-02-24 | Yes | |
| DRD1 | D1 | Dopamine | A | Human | Cryo-EM | 7JVP | - | 2.9 | R | Active | 100 | 63 | Gs | αs | - | 60 | - | Nanobody-35 |
39YLC3L0ZU
|
small-molecule | Agonist | noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, dopamine, 5-hydroxytryptamine | small-molecule | No | No | Zhuang Y, Xu P, Mao C, Wang L, Krumm B, Zhou XE, Huang S, Liu H, Cheng X, Huang XP, Shen DD, Xu T, Liu YF, Wang Y, Guo J, Jiang Y, Jiang H, Melcher K, Roth BL, Zhang Y, Zhang C, Xu HE | 10.1016/J.CELL.2021.01.027 | 2021-02-24 | Yes | |
| DRD1 | D1 | Dopamine | A | Human | Cryo-EM | 7JV5 | - | 3.0 | R | Active | 100 | 63 | Gs | αs | - | 60 | - | Nanobody-35 |
CHEMBL1160787
|
small-molecule | Agonist | noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, dopamine, 5-hydroxytryptamine | small-molecule | No | No | Zhuang Y, Xu P, Mao C, Wang L, Krumm B, Zhou XE, Huang S, Liu H, Cheng X, Huang XP, Shen DD, Xu T, Liu YF, Wang Y, Guo J, Jiang Y, Jiang H, Melcher K, Roth BL, Zhang Y, Zhang C, Xu HE | 10.1016/J.CELL.2021.01.027 | 2021-02-24 | Yes | |
| DRD1 | D1 | Dopamine | A | Human | Cryo-EM | 7JVQ | 7JVQ_refined | 3.0 | R | Active | 100 | 64 | Gs | αs | Engineered G alpha | 60 | - | Nanobody-35 |
apomorphine
|
small-molecule | Agonist | noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, dopamine, 5-hydroxytryptamine | small-molecule | No | No | Zhuang Y, Xu P, Mao C, Wang L, Krumm B, Zhou XE, Huang S, Liu H, Cheng X, Huang XP, Shen DD, Xu T, Liu YF, Wang Y, Guo J, Jiang Y, Jiang H, Melcher K, Roth BL, Zhang Y, Zhang C, Xu HE | 10.1016/J.CELL.2021.01.027 | 2021-02-24 | Yes | |
| DRD2 | D2 | Dopamine | A | Human | Cryo-EM | 7JVR | - | 2.8 | R | Active | 100 | 61 | Gi/o | αi1 | - | 63 | - | scFv16 |
bromocriptine
|
small-molecule | Agonist | dopamine | small-molecule | No | No | Zhuang Y, Xu P, Mao C, Wang L, Krumm B, Zhou XE, Huang S, Liu H, Cheng X, Huang XP, Shen DD, Xu T, Liu YF, Wang Y, Guo J, Jiang Y, Jiang H, Melcher K, Roth BL, Zhang Y, Zhang C, Xu HE | 10.1016/J.CELL.2021.01.027 | 2021-02-24 | Yes | |
| LT4R1 | BLT1 | Leukotriene | A | Human | X-ray | 7K15 | 7K15_refined | 2.9 | A | Inactive | 9 | 85 | - | - | - | - | Flavodoxin | - |
N-(tert-butylsulfonyl)-4-fluoro-2-{(3S,4R)-4-hydroxy-3-[(pyridin-2-yl)methyl]-3,4-dihydro-2H-1-benzopyran-7-yl}benzamide
|
small-molecule | Antagonist | 12R-HETE, 20-hydroxy-LTB4, LTB4 | small-molecule | No | No | Michaelian N, Sadybekov A, Besserer-Offroy E, Han GW, Krishnamurthy H, Zamlynny BA, Fradera X, Siliphaivanh P, Presland J, Spencer KB, Soisson SM, Popov P, Sarret P, Katritch V, Cherezov V | 10.1038/S41467-021-23149-1 | 2021-02-17 | Yes | |
| NTR1 | NTS1 | Neurotensin | A | Rat | X-ray | 6Z4V | - | 2.6 | A | Intermediate | 16 | 79 | - | - | - | - | DARPin D12 | - |
JMV431
|
peptide | Agonist | neurotensin, neuromedin N | peptide | No | No | Deluigi M, Klipp A, Klenk C, Merklinger L, Eberle SA, Morstein L, Heine P, Mittl PRE, Ernst P, Kamenecka TM, He Y, Vacca S, Egloff P, Honegger A, Pluckthun A | 10.1126/sciadv.abe5504 | 2021-02-10 | Yes | |
| NTR1 | NTS1 | Neurotensin | A | Rat | X-ray | 6YVR | - | 2.5 | B | Inactive | 2 | 83 | - | - | - | - | DARPin D12 | - |
JMV431
|
peptide | Agonist | neurotensin, neuromedin N | peptide | No | No | Deluigi M, Klipp A, Klenk C, Merklinger L, Eberle SA, Morstein L, Heine P, Mittl PRE, Ernst P, Kamenecka TM, He Y, Vacca S, Egloff P, Honegger A, Pluckthun A | 10.1126/sciadv.abe5504 | 2021-02-10 | Yes | |
| NTR1 | NTS1 | Neurotensin | A | Rat | X-ray | 6Z4Q | - | 2.9 | A | Inactive | 30 | 75 | - | - | - | - | DARPin D12 | - |
SR142948A
|
small-molecule | Inverse agonist | neurotensin, neuromedin N | peptide | No | No | Deluigi M, Klipp A, Klenk C, Merklinger L, Eberle SA, Morstein L, Heine P, Mittl PRE, Ernst P, Kamenecka TM, He Y, Vacca S, Egloff P, Honegger A, Pluckthun A | 10.1126/sciadv.abe5504 | 2021-02-10 | Yes | |
| NTR1 | NTS1 | Neurotensin | A | Rat | X-ray | 6ZIN | - | 2.6 | A | Inactive | 30 | 76 | - | - | - | - | DARPin D12 | - |
meclinertant
|
small-molecule | Inverse agonist | neurotensin, neuromedin N | peptide | No | No | Deluigi M, Klipp A, Klenk C, Merklinger L, Eberle SA, Morstein L, Heine P, Mittl PRE, Ernst P, Kamenecka TM, He Y, Vacca S, Egloff P, Honegger A, Pluckthun A | 10.1126/sciadv.abe5504 | 2021-02-10 | Yes | |
| NTR1 | NTS1 | Neurotensin | A | Rat | X-ray | 6Z66 | 6Z66_refined | 3.2 | A | Intermediate | 16 | 80 | - | - | - | - | DARPin D12 | - |
Apo (no ligand)
|
none | Apo (no ligand) | neurotensin, neuromedin N | peptide | No | No | Deluigi M, Klipp A, Klenk C, Merklinger L, Eberle SA, Morstein L, Heine P, Mittl PRE, Ernst P, Kamenecka TM, He Y, Vacca S, Egloff P, Honegger A, Pluckthun A | 10.1126/sciadv.abe5504 | 2021-02-10 | Yes | |
| NTR1 | NTS1 | Neurotensin | A | Rat | X-ray | 6Z4S | - | 2.7 | A | Inactive | 2 | 77 | - | - | - | - | DARPin D12 | - |
meclinertant
|
small-molecule | Inverse agonist | neurotensin, neuromedin N | peptide | No | No | Deluigi M, Klipp A, Klenk C, Merklinger L, Eberle SA, Morstein L, Heine P, Mittl PRE, Ernst P, Kamenecka TM, He Y, Vacca S, Egloff P, Honegger A, Pluckthun A | 10.1126/sciadv.abe5504 | 2021-02-10 | Yes | |
| NTR1 | NTS1 | Neurotensin | A | Rat | X-ray | 6Z8N | 6Z8N_refined | 2.8 | A | Intermediate | 16 | 80 | - | - | - | - | DARPin D12 | - |
(2~{S})-4-methyl-2-[(1-quinolin-8-ylsulfonylindol-3-yl)carbonylamino]pentanoic acid
|
small-molecule | Agonist | neurotensin, neuromedin N | peptide | No | No | Deluigi M, Klipp A, Klenk C, Merklinger L, Eberle SA, Morstein L, Heine P, Mittl PRE, Ernst P, Kamenecka TM, He Y, Vacca S, Egloff P, Honegger A, Pluckthun A | 10.1126/sciadv.abe5504 | 2021-02-10 | Yes | |
| NTR1 | NTS1 | Neurotensin | A | Rat | X-ray | 6ZA8 | 6ZA8_refined | 2.7 | A | Intermediate | 16 | 78 | - | - | - | - | DARPin D12 | - |
CHEMBL508044
|
small-molecule | Agonist (partial) | neurotensin, neuromedin N | peptide | No | No | Deluigi M, Klipp A, Klenk C, Merklinger L, Eberle SA, Morstein L, Heine P, Mittl PRE, Ernst P, Kamenecka TM, He Y, Vacca S, Egloff P, Honegger A, Pluckthun A | 10.1126/sciadv.abe5504 | 2021-02-10 | Yes | |
| OX2R | OX2 | Orexin | A | Human | Cryo-EM | 7L1U | - | 3.2 | R | Active | 100 | 63 | Gs | αs | Engineered G alpha | 58 | - | scFv16 |
Orexin-A
|
peptide | Agonist | orexin-B, orexin-A | peptide | No | No | Hong C, Byrne NJ, Zamlynny B, Tummala S, Xiao L, Shipman JM, Partridge AT, Minnick C, Breslin MJ, Rudd MT, Stachel SJ, Rada VL, Kern JC, Armacost KA, Hollingsworth SA, O'Brien JA, Hall DL, McDonald TP, Strickland C, Brooun A, Soisson SM, Hollenstein K | 10.1038/S41467-021-21087-6 | 2021-02-10 | Yes | |
| OX2R | OX2 | Orexin | A | Human | Cryo-EM | 7L1V | - | 3.0 | R | Active | 100 | 64 | Gs | αs | Engineered G alpha | 58 | - | scFv16 Nanobody-51 |
compound 1 [PMID: 33547286]
|
small-molecule | Agonist | orexin-B, orexin-A | peptide | No | No | Hong C, Byrne NJ, Zamlynny B, Tummala S, Xiao L, Shipman JM, Partridge AT, Minnick C, Breslin MJ, Rudd MT, Stachel SJ, Rada VL, Kern JC, Armacost KA, Hollingsworth SA, O'Brien JA, Hall DL, McDonald TP, Strickland C, Brooun A, Soisson SM, Hollenstein K | 10.1038/S41467-021-21087-6 | 2021-02-10 | Yes | |
| AGRG3 | ADGRG3 | ADGRG | B2 | Human | Cryo-EM | 7D77 | - | 2.9 | R | Active | 100 | 48 | Gi/o | αo | - | 61 | - | scFv16 |
HYDROCORTISONE
|
small-molecule | Agonist | - | - | No | No | Ping YQ, Mao C, Xiao P, Zhao RJ, Jiang Y, Yang Z, An WT, Shen DD, Yang F, Zhang H, Qu C, Shen Q, Tian C, Li ZJ, Li S, Wang GY, Tao X, Wen X, Zhong YN, Yang J, Yi F, Yu X, Xu HE, Zhang Y, Sun JP | 10.1038/S41586-020-03083-W | 2021-02-03 | Yes | |
| AGRG3 | ADGRG3 | ADGRG | B2 | Human | Cryo-EM | 7D76 | - | 3.1 | R | Active | 100 | 48 | Gi/o | αo | - | 61 | - | - |
Beclomethasone
|
small-molecule | Agonist | - | - | No | No | Ping YQ, Mao C, Xiao P, Zhao RJ, Jiang Y, Yang Z, An WT, Shen DD, Yang F, Zhang H, Qu C, Shen Q, Tian C, Li ZJ, Li S, Wang GY, Tao X, Wen X, Zhong YN, Yang J, Yi F, Yu X, Xu HE, Zhang Y, Sun JP | 10.1038/S41586-020-03083-W | 2021-02-03 | Yes | |
| NPY2R | Y2 | Neuropeptide Y | A | Human | X-ray | 7DDZ | 7DDZ_refined | 2.8 | A | Inactive | 1 | 76 | - | - | - | - | Flavodoxin | - |
CHEMBL1823578
|
small-molecule | Antagonist | PYY-(3-36), peptide YY, neuropeptide Y-(3-36), pancreatic polypeptide, neuropeptide Y | peptide | No | No | Tang T, Hartig C, Chen Q, Zhao W, Kaiser A, Zhang X, Zhang H, Qu H, Yi C, Ma L, Han S, Zhao Q, Beck-Sickinger AG, Wu B | 10.1038/S41467-021-21030-9 | 2021-01-27 | Yes | |
| GLP1R | GLP-1 | Glucagon | B1 | Human | Cryo-EM | 7LCI | 7LCI_refined | 2.9 | R | Active | 100 | 85 | Gs | αs | - | 62 | - | - |
danuglipron
|
small-molecule | Agonist | glucagon-like peptide 1-(7-36) amide, glucagon, glucagon-like peptide 1-(7-37) | peptide | No | No | - | - | 2021-01-20 | Yes | |
| GLP1R | GLP-1 | Glucagon | B1 | Human | Cryo-EM | 7LCJ | 7LCJ_refined | 2.8 | R | Active | 99 | 84 | - | - | - | - | - | - |
danuglipron
|
small-molecule | Agonist | glucagon-like peptide 1-(7-36) amide, glucagon, glucagon-like peptide 1-(7-37) | peptide | No | No | - | - | 2021-01-20 | Yes | |
| GLP1R | GLP-1 | Glucagon | B1 | Human | Cryo-EM | 7LCK | 7LCK_refined | 3.2 | R | Active | 99 | 84 | - | - | - | - | - | - |
danuglipron
|
small-molecule | Agonist | glucagon-like peptide 1-(7-36) amide, glucagon, glucagon-like peptide 1-(7-37) | peptide | No | No | Zhang X, Johnson RM, Drulyte I, Yu L, Kotecha A, Danev R, Wootten D, Sexton PM, Belousoff MJ | 10.1016/J.STR.2021.04.008 | 2021-01-20 | Yes | |
| NTR1 | NTS1 | Neurotensin | A | Rat | Cryo-EM | 7L0Q | - | 4.3 | C | Active | 100 | 73 | Gi/o | αi1 | - | 95 | - | - |
neurotensin
|
peptide | Agonist | neurotensin, neuromedin N | peptide | No | No | Zhang M, Gui M, Wang ZF, Gorgulla C, Yu JJ, Wu H, Sun ZJ, Klenk C, Merklinger L, Morstein L, Hagn F, Pluckthun A, Brown A, Nasr ML, Wagner G | 10.1038/S41594-020-00554-6 | 2021-01-06 | Yes | |
| NTR1 | NTS1 | Neurotensin | A | Rat | Cryo-EM | 7L0R | - | 4.2 | C | Active | 100 | 73 | Gi/o | αi1 | Non-canonical conformation | 63 | - | - |
neurotensin
|
peptide | Agonist | neurotensin, neuromedin N | peptide | No | No | Zhang M, Gui M, Wang ZF, Gorgulla C, Yu JJ, Wu H, Sun ZJ, Klenk C, Merklinger L, Morstein L, Hagn F, Pluckthun A, Brown A, Nasr ML, Wagner G | 10.1038/S41594-020-00554-6 | 2021-01-06 | Yes | |
| NTR1 | NTS1 | Neurotensin | A | Rat | Cryo-EM | 7L0S | - | 4.5 | C | Active | 100 | 73 | Gi/o | αi1 | Non-canonical conformation | 95 | - | - |
neurotensin
|
peptide | Agonist | neurotensin, neuromedin N | peptide | No | No | Zhang M, Gui M, Wang ZF, Gorgulla C, Yu JJ, Wu H, Sun ZJ, Klenk C, Merklinger L, Morstein L, Hagn F, Pluckthun A, Brown A, Nasr ML, Wagner G | 10.1038/S41594-020-00554-6 | 2021-01-06 | Yes | |
| NTR1 | NTS1 | Neurotensin | A | Rat | Cryo-EM | 7L0P | - | 4.1 | C | Active | 100 | 73 | Gi/o | αi1 | - | 63 | - | - |
neurotensin
|
peptide | Agonist | neurotensin, neuromedin N | peptide | No | No | Zhang M, Gui M, Wang ZF, Gorgulla C, Yu JJ, Wu H, Sun ZJ, Klenk C, Merklinger L, Morstein L, Hagn F, Pluckthun A, Brown A, Nasr ML, Wagner G | 10.1038/S41594-020-00554-6 | 2021-01-06 | Yes | |
| DRD2 | D2 | Dopamine | A | Human | X-ray | 7DFP | 7DFP_refined | 3.1 | A | Inactive | 1 | 57 | - | - | - | - | BRIL | Fab heavy chain Fab light chain |
spiperone
|
small-molecule | Antagonist | dopamine | small-molecule | No | No | Im D, Inoue A, Fujiwara T, Nakane T, Yamanaka Y, Uemura T, Mori C, Shiimura Y, Kimura KT, Asada H, Nomura N, Tanaka T, Yamashita A, Nango E, Tono K, Kadji FMN, Aoki J, Iwata S, Shimamura T | 10.1038/S41467-020-20221-0 | 2020-12-30 | Yes | |
| ADRB2 | β2 | Adrenoceptors | A | Human | Cryo-EM | 7DHR | 7DHR_refined | 3.8 | R | Active | 100 | 69 | Gs | αs | - | 49 | - | Nanobody-35 |
LEVISOPRENALINE
|
small-molecule | Agonist | Zn2+, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline | small-molecule | No | No | - | - | 2020-12-16 | Yes | |
| ADRB2 | β2 | Adrenoceptors | A | Human | Cryo-EM | 7DHI | - | 3.3 | R | Active | 100 | 70 | Gs | αs | - | 55 | - | Nanobody-35 |
levosalbutamol
|
small-molecule | Agonist | Zn2+, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline | small-molecule | No | No | Yang F, Ling S, Zhou Y, Zhang Y, Lv P, Liu S, Fang W, Sun W, Hu LA, Zhang L, Shi P, Tian C | 10.1093/NSR/NWAA284 | 2020-12-16 | Yes | |
| GLP2R | GLP-2 | Glucagon | B1 | Human | Cryo-EM | 7D68 | - | 3.0 | R | Active | 100 | 53 | Gs | αs | - | 57 | - | Nanobody-35 |
glucagon
|
peptide | Agonist | glucagon-like peptide 2-(3-33), glucagon-like peptide 2 | peptide | No | No | Sun W, Chen LN, Zhou Q, Zhao LH, Yang D, Zhang H, Cong Z, Shen DD, Zhao F, Zhou F, Cai X, Chen Y, Zhou Y, Gadgaard S, van der Velden WJC, Zhao S, Jiang Y, Rosenkilde MM, Xu HE, Zhang Y, Wang MW | 10.1038/S41422-020-00442-0 | 2020-12-16 | Yes | |
| STE2 | STE2 | STE2 | D1 | strain ATCC 204508 / S288c | Cryo-EM | 7AD3 | - | 3.5 | A | Active | - | 69 | GPa1 family | αPa1 | Two alpha subunits bound to STE2 dimer | 46 | - | - |
Alpha-factor mating pheromone
|
peptide | Agonist | - | - | No | No | Velazhahan V, Ma N, Pandy-Szekeres G, Kooistra AJ, Lee Y, Gloriam DE, Vaidehi N, Tate CG | 10.1038/S41586-020-2994-1 | 2020-12-09 | Yes | |
| ADRB1 | β1 | Adrenoceptors | A | Human | X-ray | 7BU6 | 7BU6_refined | 2.7 | A | Active | 99 | 58 | - | - | - | - | T4-Lysozyme | Camelid antibody fragment Nb6B9 |
Noradrenaline
|
small-molecule | Agonist | (-)-adrenaline, (-)-noradrenaline, noradrenaline, L-NOREPINEPHRINE | small-molecule | No | No | Xu X, Kaindl J, Clark MJ, Hubner H, Hirata K, Sunahara RK, Gmeiner P, Kobilka BK, Liu X | 10.1038/S41422-020-00424-2 | 2020-12-02 | Yes | |
| ADRB1 | β1 | Adrenoceptors | A | Human | X-ray | 7BTS | 7BTS_refined | 3.1 | A | Active | 99 | 58 | - | - | - | - | T4-Lysozyme | Camelid antibody fragment Nb6B9 |
(-)-adrenaline
|
small-molecule | Agonist | (-)-adrenaline, (-)-noradrenaline, noradrenaline, L-NOREPINEPHRINE | small-molecule | No | No | Xu X, Kaindl J, Clark MJ, Hubner H, Hirata K, Sunahara RK, Gmeiner P, Kobilka BK, Liu X | 10.1038/S41422-020-00424-2 | 2020-12-02 | Yes | |
| ADRB1 | β1 | Adrenoceptors | A | Human | X-ray | 7BU7 | 7BU7_refined | 2.6 | A | Active | 99 | 58 | - | - | - | - | T4-Lysozyme | Camelid antibody fragment Nb6B9 |
CHEMBL1615159
|
small-molecule | Agonist | (-)-adrenaline, (-)-noradrenaline, noradrenaline, L-NOREPINEPHRINE | small-molecule | No | No | Xu X, Kaindl J, Clark MJ, Hubner H, Hirata K, Sunahara RK, Gmeiner P, Kobilka BK, Liu X | 10.1038/S41422-020-00424-2 | 2020-12-02 | Yes | |
| ADRB1 | β1 | Adrenoceptors | A | Human | X-ray | 7BVQ | 7BVQ_refined | 2.5 | A | Inactive | 0 | 60 | - | - | - | - | T4-Lysozyme | - |
Carazolol
|
small-molecule | Inverse agonist | (-)-adrenaline, (-)-noradrenaline, noradrenaline, L-NOREPINEPHRINE | small-molecule | No | No | Xu X, Kaindl J, Clark MJ, Hubner H, Hirata K, Sunahara RK, Gmeiner P, Kobilka BK, Liu X | 10.1038/S41422-020-00424-2 | 2020-12-02 | Yes | |
| AA2AR | A2A | Adenosine | A | Human | X-ray | 6LPK | 6LPK_refined | 1.8 | A | Inactive | 1 | 72 | - | - | - | - | BRIL | - |
ZM-241385
|
small-molecule | Antagonist | adenosine | small-molecule | No | No | - | - | 2020-11-25 | Yes | |
| AA2AR | A2A | Adenosine | A | Human | X-ray | 6LPL | 6LPL_refined | 2.0 | A | Inactive | 1 | 72 | - | - | - | - | BRIL | - |
ZM-241385
|
small-molecule | Antagonist | adenosine | small-molecule | No | No | Ihara K, Hato M, Nakane T, Yamashita K, Kimura-Someya T, Hosaka T, Ishizuka-Katsura Y, Tanaka R, Tanaka T, Sugahara M, Hirata K, Yamamoto M, Nureki O, Tono K, Nango E, Iwata S, Shirouzu M | 10.1038/S41598-020-76277-X | 2020-11-25 | Yes | |
| AA2AR | A2A | Adenosine | A | Human | X-ray | 6LPJ | 6LPJ_refined | 1.8 | A | Inactive | 1 | 72 | - | - | - | - | BRIL | - |
ZM-241385
|
small-molecule | Antagonist | adenosine | small-molecule | No | No | Ihara K, Hato M, Nakane T, Yamashita K, Kimura-Someya T, Hosaka T, Ishizuka-Katsura Y, Tanaka R, Tanaka T, Sugahara M, Hirata K, Yamamoto M, Nureki O, Tono K, Nango E, Iwata S, Shirouzu M | 10.1038/S41598-020-76277-X | 2020-11-25 | Yes | |
| AA2AR | A2A | Adenosine | A | Human | X-ray | 6WQA | 6WQA_refined | 2.0 | A | Inactive | 1 | 72 | - | - | - | - | BRIL | - |
ZM-241385
|
small-molecule | Antagonist | adenosine | small-molecule | No | No | Lee MY, Geiger J, Ishchenko A, Han GW, Barty A, White TA, Gati C, Batyuk A, Hunter MS, Aquila A, Boutet S, Weierstall U, Cherezov V, Liu W | 10.1107/S2052252520012701 | 2020-11-18 | Yes | |
| GHRHR | GHRH | Glucagon | B1 | Human | Cryo-EM | 7CZ5 | 7CZ5_refined | 2.6 | R | Active | 100 | 64 | Gs | αs | - | 58 | - | Nanobody-35 |
Somatoliberin
|
peptide | Agonist | GHRH | peptide | No | No | Zhou F, Zhang H, Cong Z, Zhao LH, Zhou Q, Mao C, Cheng X, Shen DD, Cai X, Ma C, Wang Y, Dai A, Zhou Y, Sun W, Zhao F, Zhao S, Jiang H, Jiang Y, Yang D, Eric Xu H, Zhang Y, Wang MW | 10.1038/S41467-020-18945-0 | 2020-11-18 | Yes | |
| GLP1R | GLP-1 | Glucagon | B1 | Human | Cryo-EM | 6XOX | - | 3.1 | R | Active | 100 | 82 | Gs | αs | - | 56 | - | scFv16 Nanobody-35 |
orforglipron
|
small-molecule | Agonist | glucagon-like peptide 1-(7-36) amide, glucagon, glucagon-like peptide 1-(7-37) | peptide | No | No | Kawai T, Sun B, Yoshino H, Feng D, Suzuki Y, Fukazawa M, Nagao S, Wainscott DB, Showalter AD, Droz BA, Kobilka TS, Coghlan MP, Willard FS, Kawabe Y, Kobilka BK, Sloop KW | 10.1073/PNAS.2014879117 | 2020-11-18 | Yes | |
| PE2R4 | EP4 | Prostanoid | A | Human | Cryo-EM | 7D7M | 7D7M_refined | 3.3 | A | Active | 100 | 58 | Gs | αs | - | 58 | - | Nanobody-35 |
PGE2
|
small-molecule | Agonist | PGE1, PGF2α, PGI2, PGE2, thromboxane A2, PGD2 | small-molecule | No | No | Nojima S, Fujita Y, Kimura KT, Nomura N, Suno R, Morimoto K, Yamamoto M, Noda T, Iwata S, Shigematsu H, Kobayashi T | 10.1016/J.STR.2020.11.007 | 2020-11-18 | Yes | |
| GABR2 | GABAB2 | GABAB | C | Human | Cryo-EM | 7CUM | - | 3.5 | B | Inactive | - | 72 | - | - | - | - | - | - |
CGP 54626A
Unknown ligand |
small-molecule none |
NAM | - | - | No | No | Kim Y, Jeong E, Jeong JH, Kim Y, Cho Y | 10.1016/J.JMB.2020.09.023 | 2020-11-11 | Yes | |
| GABR2 | GABAB2 | GABAB | C | Human | Cryo-EM | 7CA5 | - | 7.6 | B | Inactive | - | 70 | - | - | - | - | - | - |
Apo (no ligand)
|
none | Apo (no ligand) | - | - | No | No | Kim Y, Jeong E, Jeong JH, Kim Y, Cho Y | 10.1016/J.JMB.2020.09.023 | 2020-11-11 | Yes | |
| GABR2 | GABAB2 | GABAB | C | Human | Cryo-EM | 7CA3 | - | 4.5 | B | Active | - | 72 | - | - | - | - | - | - |
BHFF
|
small-molecule | PAM | - | - | No | No | Kim Y, Jeong E, Jeong JH, Kim Y, Cho Y | 10.1016/J.JMB.2020.09.023 | 2020-11-11 | Yes | |
| SCTR | secretin | Glucagon | B1 | Human | Cryo-EM | 7D3S | 7D3S_refined | 2.9 | R | Active | 100 | 60 | Gs | αs | - | 58 | - | Nanobody-35 |
SECRETIN
|
protein | Agonist | secretin, VIP | peptide | No | No | Fukuhara S, Kobayashi K, Kusakizako T, Iida W, Kato M, Shihoya W, Nureki O | 10.1016/J.BBRC.2020.08.042 | 2020-11-04 | Yes | |
| GNRHR | GnRH1 | Gonadotrophin-releasing hormone | A | Human | X-ray | 7BR3 | 7BR3_refined | 2.8 | A | Inactive | 16 | 84 | - | - | - | - | GlgA glycogen synthase | - |
elagolix
|
small-molecule | Antagonist | GnRH I, GnRH II | peptide | No | No | Yan W, Cheng L, Wang W, Wu C, Yang X, Du X, Ma L, Qi S, Wei Y, Lu Z, Yang S, Shao Z | 10.1038/S41467-020-19109-W | 2020-10-07 | Yes | |
| SMO | SMO | Frizzled | F | Human | Cryo-EM | 6XBK | - | 3.2 | R | Active | 100 | 59 | Gi/o | αi1 | - | 61 | - | scFv16 |
Cholesterol
|
small-molecule | Agonist | - | - | No | No | Qi X, Friedberg L, De Bose-Boyd R, Long T, Li X | 10.1038/S41589-020-0646-2 | 2020-09-30 | Yes | |
| SMO | SMO | Frizzled | F | Human | Cryo-EM | 6XBM | - | 3.2 | R | Active | 100 | 42 | Gi/o | αi1 | - | 61 | - | scFv16 |
24,25-Epoxy-cholesterol
24,25-Epoxy-cholesterol |
small-molecule small-molecule |
Agonist PAM |
- | - | No | No | Qi X, Friedberg L, De Bose-Boyd R, Long T, Li X | 10.1038/S41589-020-0646-2 | 2020-09-30 | Yes | |
| SMO | SMO | Frizzled | F | Human | Cryo-EM | 6XBJ | - | 3.9 | R | Active | 100 | 59 | Gi/o | αi1 | - | 61 | - | scFv16 |
Cholesterol
|
small-molecule | Agonist | - | - | No | No | - | - | 2020-09-30 | Yes | |
| SMO | SMO | Frizzled | F | Human | Cryo-EM | 6XBL | - | 3.9 | R | Active | 100 | 59 | Gi/o | αi1 | - | 61 | - | scFv16 |
Cholesterol
SAG1.3 |
small-molecule small-molecule |
Agonist PAM |
- | - | No | No | Qi X, Friedberg L, De Bose-Boyd R, Long T, Li X | 10.1038/S41589-020-0646-2 | 2020-09-30 | Yes | |
| 5HT2A | 5-HT2A | 5-Hydroxytryptamine | A | Human | X-ray | 6WGT | 6WGT_refined | 3.4 | B | Inactive | 1 | 59 | - | - | - | - | BRIL | - |
Lysergide
|
small-molecule | Agonist | tryptamine, 5-hydroxytryptamine | small-molecule | No | No | Kim K, Che T, Panova O, DiBerto JF, Lyu J, Krumm BE, Wacker D, Robertson MJ, Seven AB, Nichols DE, Shoichet BK, Skiniotis G, Roth BL | 10.1016/J.CELL.2020.08.024 | 2020-09-23 | Yes | |
| 5HT2A | 5-HT2A | 5-Hydroxytryptamine | A | Human | X-ray | 6WH4 | 6WH4_refined | 3.4 | C | Inactive | 1 | 59 | - | - | - | - | BRIL | - |
CHEMBL428892
|
small-molecule | Inverse agonist | tryptamine, 5-hydroxytryptamine | small-molecule | No | No | Kim K, Che T, Panova O, DiBerto JF, Lyu J, Krumm BE, Wacker D, Robertson MJ, Seven AB, Nichols DE, Shoichet BK, Skiniotis G, Roth BL | 10.1016/J.CELL.2020.08.024 | 2020-09-23 | Yes | |
| 5HT2A | 5-HT2A | 5-Hydroxytryptamine | A | Human | Cryo-EM | 6WHA | - | 3.4 | A | Active | 100 | 52 | Gq/11 | αq | Gq-Gi2-Gs chimera | 57 | BRIL | scFv16 |
CHEMBL5184791
|
small-molecule | Agonist | tryptamine, 5-hydroxytryptamine | small-molecule | No | No | Kim K, Che T, Panova O, DiBerto JF, Lyu J, Krumm BE, Wacker D, Robertson MJ, Seven AB, Nichols DE, Shoichet BK, Skiniotis G, Roth BL | 10.1016/J.CELL.2020.08.024 | 2020-09-23 | Yes | |
| AA2AR | A2A | Adenosine | A | Human | X-ray | 6ZDR | 6ZDR_refined | 1.9 | A | Inactive | 1 | 72 | - | - | - | - | BRIL | - |
CHEMBL2030687
|
small-molecule | Antagonist | adenosine | small-molecule | No | No | Jespers W, Verdon G, Azuaje J, Majellaro M, Keranen H, Garcia-Mera X, Congreve M, Deflorian F, de Graaf C, Zhukov A, Dore AS, Mason JS, Aqvist J, Cooke RM, Sotelo E, Gutierrez-de-Teran H | 10.1002/ANIE.202003788 | 2020-09-16 | Yes | |
| AA2AR | A2A | Adenosine | A | Human | X-ray | 6ZDV | 6ZDV_refined | 2.1 | A | Inactive | 1 | 72 | - | - | - | - | BRIL | - |
2-Methyl-3-(4-methylthiazol-2-yl)-4-oxo-6-propyl-4H-chromen-7-yl acetate
|
small-molecule | Antagonist | adenosine | small-molecule | No | No | Jespers W, Verdon G, Azuaje J, Majellaro M, Keranen H, Garcia-Mera X, Congreve M, Deflorian F, de Graaf C, Zhukov A, Dore AS, Mason JS, Aqvist J, Cooke RM, Sotelo E, Gutierrez-de-Teran H | 10.1002/ANIE.202003788 | 2020-09-16 | Yes | |
| SUCR1 | succinate | Succinate | A | Rat | X-ray | 6Z10 | 6Z10_refined | 2.3 | A | Active | 56 | 90 | - | - | - | - | - | Nanobody-6 |
CHEMBL4751488
|
small-molecule | Antagonist | - | - | No | No | Velcicky J,Wilcken R,Cotesta S,Janser P,Schlapbach A,Wagner T,Piechon P,Villard F,Bouhelal R,Piller F,Harlfinger S,Stringer R,Fehlmann D,Kaupmann K,Littlewood-Evans A,Haffke M,Gommermann N | 10.1021/acs.jmedchem.0c01020 | 2020-09-16 | Yes | |
| GLP1R | GLP-1 | Glucagon | B1 | Human | Cryo-EM | 6X1A | - | 2.5 | R | Active | 100 | 84 | Gs | αs | - | 89 | - | Nanobody-35 |
danuglipron
|
small-molecule | Agonist | glucagon-like peptide 1-(7-36) amide, glucagon, glucagon-like peptide 1-(7-37) | peptide | No | No | Zhang X, Belousoff MJ, Zhao P, Kooistra AJ, Truong TT, Ang SY, Underwood CR, Egebjerg T, Senel P, Stewart GD, Liang YL, Glukhova A, Venugopal H, Christopoulos A, Furness SGB, Miller LJ, Reedtz-Runge S, Langmead CJ, Gloriam DE, Danev R, Sexton PM, Wootten D | 10.1016/J.MOLCEL.2020.09.020 | 2020-09-09 | Yes | |
| GLP1R | GLP-1 | Glucagon | B1 | Human | Cryo-EM | 6X18 | - | 2.1 | R | Active | 100 | 83 | Gs | αs | - | 90 | - | Nanobody-35 |
CHEMBL410972
|
protein | Agonist | glucagon-like peptide 1-(7-36) amide, glucagon, glucagon-like peptide 1-(7-37) | peptide | No | No | Zhang X, Belousoff MJ, Zhao P, Kooistra AJ, Truong TT, Ang SY, Underwood CR, Egebjerg T, Senel P, Stewart GD, Liang YL, Glukhova A, Venugopal H, Christopoulos A, Furness SGB, Miller LJ, Reedtz-Runge S, Langmead CJ, Gloriam DE, Danev R, Sexton PM, Wootten D | 10.1016/J.MOLCEL.2020.09.020 | 2020-09-09 | Yes | |
| GLP1R | GLP-1 | Glucagon | B1 | Human | Cryo-EM | 6X19 | - | 2.1 | R | Active | 100 | 84 | Gs | αs | - | 89 | - | Nanobody-35 |
CHU-128
|
small-molecule | Agonist | glucagon-like peptide 1-(7-36) amide, glucagon, glucagon-like peptide 1-(7-37) | peptide | No | No | Zhang X, Belousoff MJ, Zhao P, Kooistra AJ, Truong TT, Ang SY, Underwood CR, Egebjerg T, Senel P, Stewart GD, Liang YL, Glukhova A, Venugopal H, Christopoulos A, Furness SGB, Miller LJ, Reedtz-Runge S, Langmead CJ, Gloriam DE, Danev R, Sexton PM, Wootten D | 10.1016/J.MOLCEL.2020.09.020 | 2020-09-09 | Yes | |
| GPBAR | GPBA | Bile acid | A | Human | Cryo-EM | 7CFM | - | 3.0 | R | Active | 100 | 83 | Gs | αs | - | 58 | - | Nanobody-35 |
CHEMBL2331646
|
small-molecule | Agonist | lithocholic acid, deoxycholic acid, cholic acid, chenodeoxycholic acid | small-molecule | No | No | Yang F, Mao C, Guo L, Lin J, Ming Q, Xiao P, Wu X, Shen Q, Guo S, Shen DD, Lu R, Zhang L, Huang S, Ping Y, Zhang C, Ma C, Zhang K, Liang X, Shen Y, Nan F, Yi F, Luca VC, Zhou J, Jiang C, Sun JP, Xie X, Yu X, Zhang Y | 10.1038/S41586-020-2569-1 | 2020-09-09 | Yes | |
| GPBAR | GPBA | Bile acid | A | Human | Cryo-EM | 7CFN | 7CFN_refined | 3.0 | R | Active | 100 | 83 | Gs | αs | - | 59 | - | Nanobody-35 |
INT-777
INT-777 |
small-molecule small-molecule |
Agonist PAM |
lithocholic acid, deoxycholic acid, cholic acid, chenodeoxycholic acid | small-molecule | No | No | Yang F, Mao C, Guo L, Lin J, Ming Q, Xiao P, Wu X, Shen Q, Guo S, Shen DD, Lu R, Zhang L, Huang S, Ping Y, Zhang C, Ma C, Zhang K, Liang X, Shen Y, Nan F, Yi F, Luca VC, Zhou J, Jiang C, Sun JP, Xie X, Yu X, Zhang Y | 10.1038/S41586-020-2569-1 | 2020-09-09 | Yes | |
| ADRB1 | β1 | Adrenoceptors | A | Wild turkey | Cryo-EM | 7JJO | - | 2.6 | R | Active | 100 | 58 | Gs | αs | - | 51 | - | Nanobody-35 |
LEVISOPRENALINE
|
small-molecule | Agonist | - | - | No | No | Su M, Zhu L, Zhang Y, Paknejad N, Dey R, Huang J, Lee MY, Williams D, Jordan KD, Eng ET, Ernst OP, Meyerson JR, Hite RK, Walz T, Liu W, Huang XY | 10.1016/J.MOLCEL.2020.08.001 | 2020-09-02 | Yes | |
| CXCR2 | CXCR2 | Chemokine | A | Human | X-ray | 6LFL | 6LFL_refined | 3.2 | A | Inactive | 5 | 76 | - | - | - | - | GlgA glycogen synthase | - |
4-[[3,4-Dioxo-2-[[(1R)-1-(4-propan-2-ylfuran-2-yl)propyl]amino]cyclobuten-1-yl]amino]-3-hydroxy-N,N-dimethylpyridine-2-carboxamide
|
small-molecule | Allosteric antagonist | CXCL3, CXCL6, CXCL7, CXCL1, CXCL8, CXCL2, CXCL5 | peptide | No | No | Liu K, Wu L, Yuan S, Wu M, Xu Y, Sun Q, Li S, Zhao S, Hua T, Liu ZJ | 10.1038/S41586-020-2492-5 | 2020-09-02 | Yes | |
| CXCR2 | CXCR2 | Chemokine | A | Human | Cryo-EM | 6LFO | 6LFO_refined | 3.4 | R | Active | 100 | 85 | Gi/o | αi1 | - | 65 | - | scFv16 |
Interleukin-8
|
protein | Agonist | CXCL3, CXCL6, CXCL7, CXCL1, CXCL8, CXCL2, CXCL5 | peptide | No | No | Liu K, Wu L, Yuan S, Wu M, Xu Y, Sun Q, Li S, Zhao S, Hua T, Liu ZJ | 10.1038/S41586-020-2492-5 | 2020-09-02 | Yes | |
| CXCR2 | CXCR2 | Chemokine | A | Human | Cryo-EM | 6LFM | 6LFM_refined | 3.5 | R | Active | 100 | 85 | Gi/o | αi1 | - | 65 | - | scFv16 |
Interleukin-8
|
protein | Agonist | CXCL3, CXCL6, CXCL7, CXCL1, CXCL8, CXCL2, CXCL5 | peptide | No | No | Liu K, Wu L, Yuan S, Wu M, Xu Y, Sun Q, Li S, Zhao S, Hua T, Liu ZJ | 10.1038/S41586-020-2492-5 | 2020-09-02 | Yes | |
| GPBAR | GPBA | Bile acid | A | Human | Cryo-EM | 7BW0 | 7BW0_refined | 3.9 | R | Active | 100 | 85 | Gs | αs | - | 57 | BRIL | Nanobody-35 | - | - | - | lithocholic acid, deoxycholic acid, cholic acid, chenodeoxycholic acid | small-molecule | No | No | Chen G, Wang X, Ge Y, Ma L, Chen Q, Liu H, Du Y, Ye RD, Hu H, Ren R | 10.1038/S41392-020-00262-Z | 2020-09-02 | Yes | |
| VIPR1 | VPAC1 | VIP and PACAP | B1 | Human | Cryo-EM | 6VN7 | 6VN7_refined | 3.2 | R | Active | 100 | 58 | Gs | αs | - | 61 | - | Nanobody-35 |
[Ac-His1]PACAP-27
|
peptide | Agonist | secretin, PHM, PACAP-27, VIP, PACAP-38, PHI, GHRH | peptide | No | No | Duan J, Shen DD, Zhou XE, Bi P, Liu QF, Tan YX, Zhuang YW, Zhang HB, Xu PY, Huang SJ, Ma SS, He XH, Melcher K, Zhang Y, Xu HE, Jiang Y | 10.1038/S41467-020-17933-8 | 2020-09-02 | Yes | |
| GLP1R | GLP-1 | Glucagon | B1 | Human | Cryo-EM | 7C2E | - | 4.2 | R | Active | 100 | 82 | Gs | αs | - | 49 | - | Nanobody-35 |
2-[[4-[6-[(4-cyano-2-fluoranyl-phenyl)methoxy]pyridin-2-yl]-3,6-dihydro-2~{H}-pyridin-1-yl]methyl]-3-[[(2~{S})-oxetan-2-yl]methyl]imidazo[4,5-b]pyridine-5-carboxylic acid
|
small-molecule | Agonist | glucagon-like peptide 1-(7-36) amide, glucagon, glucagon-like peptide 1-(7-37) | peptide | No | No | Ma H, Huang W, Wang X, Zhao L, Jiang Y, Liu F, Guo W, Sun X, Zhong W, Yuan D, Xu HE | 10.1038/S41422-020-0384-8 | 2020-08-26 | Yes | |
| FZD5 | FZD5 | Frizzled | F | Human | Cryo-EM | 6WW2 | 6WW2_refined | 3.7 | R | Inactive | 19 | 55 | - | - | - | - | BRIL | anti-BRIL Fab heavy chain anti-BRIL Fab light chain anti-Fab Nanobody |
Apo (no ligand)
|
none | Apo (no ligand) | - | - | No | No | Tsutsumi N, Mukherjee S, Waghray D, Janda CY, Jude KM, Miao Y, Burg JS, Aduri NG, Kossiakoff AA, Gati C, Garcia KC | 10.7554/ELIFE.58464 | 2020-08-19 | Yes | |
| GHSR | ghrelin | Ghrelin | A | Human | X-ray | 6KO5 | 6KO5_refined | 3.3 | A | Inactive | 1 | 80 | - | - | - | - | BRIL | Fab7881 heavy chain Fab7881 light chain |
CHEMBL1956994
|
small-molecule | Antagonist | [des-Gln14]ghrelin, ghrelin | peptide | No | No | Shiimura Y, Horita S, Hamamoto A, Asada H, Hirata K, Tanaka M, Mori K, Uemura T, Kobayashi T, Iwata S, Kojima M | 10.1038/S41467-020-17554-1 | 2020-08-12 | Yes | |
| GLR | glucagon | Glucagon | B1 | Human | Cryo-EM | 6WPW | 6WPW_refined | 3.1 | R | Active | 100 | 83 | Gs | αs | - | 56 | - | Nanobody-35 |
Glucagon derivative ZP3780
|
peptide | Agonist | glucagon | peptide | No | No | Hilger D, Kumar KK, Hu H, Pedersen MF, O'Brien ES, Giehm L, Jennings C, Eskici G, Inoue A, Lerch M, Mathiesen JM, Skiniotis G, Kobilka BK | 10.1126/SCIENCE.ABA3373 | 2020-08-12 | Yes | |
| SCTR | secretin | Glucagon | B1 | Human | Cryo-EM | 6WI9 | 6WI9_refined | 4.3 | R | Active | 100 | 84 | Gs | αs | - | 49 | - | Nanobody-35 |
SECRETIN
|
protein | Agonist | secretin, VIP | peptide | No | No | Dong M, Deganutti G, Piper SJ, Liang YL, Khoshouei M, Belousoff MJ, Harikumar KG, Reynolds CA, Glukhova A, Furness SGB, Christopoulos A, Danev R, Wootten D, Sexton PM, Miller LJ | 10.1038/S41467-020-17791-4 | 2020-08-12 | Yes | |
| SCTR | secretin | Glucagon | B1 | Human | Cryo-EM | 6WZG | 6WZG_refined | 2.3 | R | Active | 100 | 86 | Gs | αs | - | 61 | - | Nanobody-35 |
SECRETIN
|
protein | Agonist | secretin, VIP | peptide | No | No | Dong M, Deganutti G, Piper SJ, Liang YL, Khoshouei M, Belousoff MJ, Harikumar KG, Reynolds CA, Glukhova A, Furness SGB, Christopoulos A, Danev R, Wootten D, Sexton PM, Miller LJ | 10.1038/S41467-020-17791-4 | 2020-08-12 | Yes | |
| ADRB2 | β2 | Adrenoceptors | A | Human | Cryo-EM | 7BZ2 | 7BZ2_refined | 3.8 | R | Active | 100 | 69 | Gs | αs | - | 50 | - | Nanobody-35 |
ARFORMOTEROL
|
small-molecule | Agonist | Zn2+, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline | small-molecule | No | No | Zhang Y, Yang F, Ling S, Lv P, Zhou Y, Fang W, Sun W, Zhang L, Shi P, Tian C | 10.1038/S41421-020-0176-9 | 2020-08-05 | Yes | |
| OXYR | OT | Vasopressin and oxytocin | A | Human | X-ray | 6TPK | 6TPK_refined | 3.2 | A | Inactive | 16 | 68 | - | - | - | - | GlgA glycogen synthase | - |
retosiban
|
small-molecule | Antagonist | oxytocin, vasopressin | peptide | No | No | Waltenspuhl Y, Schoppe J, Ehrenmann J, Kummer L, Pluckthun A | 10.1126/SCIADV.ABB5419 | 2020-08-05 | Yes | |
| 5HT1B | 5-HT1B | 5-Hydroxytryptamine | A | Human | X-ray | 7C61 | 7C61_refined | 3.0 | A | Inactive | 16 | 68 | - | - | - | - | BRIL | IgG heavy chain IgG light chain |
ergotamine
|
small-molecule | Antagonist | 5-HT-moduline, tryptamine, 5-hydroxytryptamine | small-molecule | No | No | Miyagi H, Asada H, Suzuki M, Takahashi Y, Yasunaga M, Suno C, Iwata S, Saito JI | 10.1038/S41598-020-68355-X | 2020-07-29 | Yes | |
| AGTR2 | AT2 | Angiotensin | A | Human | X-ray | 7C6A | 7C6A_refined | 3.4 | A | Active | 98 | 77 | - | - | - | - | BRIL | IgG heavy chain IgG light chain |
CHEMBL404594
|
protein | Agonist | angiotensin III, angiotensin-(1-7), angiotensin II | peptide | No | No | Miyagi H, Asada H, Suzuki M, Takahashi Y, Yasunaga M, Suno C, Iwata S, Saito JI | 10.1038/S41598-020-68355-X | 2020-07-29 | Yes | |
| GLP1R | GLP-1 | Glucagon | B1 | Human | Cryo-EM | 6VCB | - | 3.3 | R | Active | 100 | 82 | Gs | αs | - | 57 | - | Nanobody-35 |
glucagon-like peptide 1-(7-37)
CHEMBL5197819 |
peptide small-molecule |
Agonist PAM |
glucagon-like peptide 1-(7-36) amide, glucagon, glucagon-like peptide 1-(7-37) | peptide | No | No | Bueno AB, Sun B, Willard FS, Feng D, Ho JD, Wainscott DB, Showalter AD, Vieth M, Chen Q, Stutsman C, Chau B, Ficorilli J, Agejas FJ, Cumming GR, Jimenez A, Rojo I, Kobilka TS, Kobilka BK, Sloop KW | 10.1038/S41589-020-0589-7 | 2020-07-22 | Yes | |
| AA2AR | A2A | Adenosine | A | Human | X-ray | 6S0Q | 6S0Q_refined | 2.7 | A | Inactive | 1 | 72 | - | - | - | - | BRIL | - |
ZM-241385
|
small-molecule | Antagonist | adenosine | small-molecule | No | No | Nass K, Cheng R, Vera L, Mozzanica A, Redford S, Ozerov D, Basu S, James D, Knopp G, Cirelli C, Martiel I, Casadei C, Weinert T, Nogly P, Skopintsev P, Usov I, Leonarski F, Geng T, Rappas M, Dore AS, Cooke R, Nasrollahi Shirazi S, Dworkowski F, Sharpe M, Olieric N, Bacellar C, Bohinc R, Steinmetz MO, Schertler G, Abela R, Patthey L, Schmitt B, Hennig M, Standfuss J, Wang M, Milne CJ | 10.1107/S2052252520011379 | 2020-07-15 | Yes | |
| AA2AR | A2A | Adenosine | A | Human | X-ray | 6S0L | 6S0L_refined | 2.7 | A | Inactive | 1 | 72 | - | - | - | - | BRIL | - |
ZM-241385
|
small-molecule | Antagonist | adenosine | small-molecule | No | No | Nass K, Cheng R, Vera L, Mozzanica A, Redford S, Ozerov D, Basu S, James D, Knopp G, Cirelli C, Martiel I, Casadei C, Weinert T, Nogly P, Skopintsev P, Usov I, Leonarski F, Geng T, Rappas M, Dore AS, Cooke R, Nasrollahi Shirazi S, Dworkowski F, Sharpe M, Olieric N, Bacellar C, Bohinc R, Steinmetz MO, Schertler G, Abela R, Patthey L, Schmitt B, Hennig M, Standfuss J, Wang M, Milne CJ | 10.1107/S2052252520011379 | 2020-07-15 | Yes | |
| OX1R | OX1 | Orexin | A | Human | X-ray | 6V9S | 6V9S_refined | 3.5 | A | Inactive | 1 | 72 | - | - | - | - | GlgA glycogen synthase | - |
JH112
|
small-molecule | Antagonist | orexin-B, orexin-A | peptide | No | No | Hellmann J, Drabek M, Yin J, Gunera J, Proll T, Kraus F, Langmead CJ, Hubner H, Weikert D, Kolb P, Rosenbaum DM, Gmeiner P | 10.1073/PNAS.2002704117 | 2020-07-15 | Yes | |
| ACM1 | M1 | Acetylcholine (muscarinic) | A | Human | X-ray | 6WJC | - | 2.6 | A | Inactive | 3 | 62 | - | - | - | - | T4-Lysozyme | - |
HYOSCYAMINE
muscarinic toxin 7 |
small-molecule peptide |
Antagonist NAM |
acetylcholine | small-molecule | No | No | Maeda S, Xu J, N Kadji FM, Clark MJ, Zhao J, Tsutsumi N, Aoki J, Sunahara RK, Inoue A, Garcia KC, Kobilka BK | 10.1126/SCIENCE.AAX2517 | 2020-07-08 | Yes | |
| GABR1 | GABAB1 | GABAB | C | Human | Cryo-EM | 6W2Y | - | 3.2 | B | Inactive | - | 69 | - | - | - | - | - | - |
CGP55845
1-Stearoyl-2-oleoyl-sn-glycero-3-phosphoethanolamine |
small-molecule small-molecule |
Inverse agonist NAM |
GABA | small-molecule | No | No | Papasergi-Scott MM, Robertson MJ, Seven AB, Panova O, Mathiesen JM, Skiniotis G | 10.1038/S41586-020-2469-4 | 2020-07-01 | Yes | |
| GABR2 | GABAB2 | GABAB | C | Human | Cryo-EM | 6W2X | - | 3.6 | B | Inactive | - | 71 | - | - | - | - | - | - |
CGP55845
1-Stearoyl-2-oleoyl-sn-glycero-3-phosphoethanolamine |
small-molecule small-molecule |
Inverse agonist NAM |
- | - | No | No | - | - | 2020-07-01 | Yes | |
| GABR2 | GABAB2 | GABAB | C | Human | Cryo-EM | 7C7Q | - | 3.0 | B | Active | - | 71 | - | - | - | - | - | - |
(-)-baclofen
BHFF |
small-molecule small-molecule |
Agonist PAM |
- | - | No | No | - | - | 2020-07-01 | Yes | |
| GABR2 | GABAB2 | GABAB | C | Human | Cryo-EM | 6WIV | - | 3.3 | B | Inactive | - | 71 | - | - | - | - | - | - |
[(2R)-3-[(Z)-icos-11-enoyl]oxy-2-[(Z)-octadec-9-enoyl]oxypropyl] 2-(trimethylazaniumyl)ethylphosphate
(2R)-3-{[(S)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-{[(9Z)-octadec-9-enoyl]oxy}propyl(5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate |
small-molecule small-molecule |
NAM | - | - | No | No | Park J, Fu Z, Frangaj A, Liu J, Mosyak L, Shen T, Slavkovich VN, Ray KM, Taura J, Cao B, Geng Y, Zuo H, Kou Y, Grassucci R, Chen S, Liu Z, Lin X, Williams JP, Rice WJ, Eng ET, Huang RK, Soni RK, Kloss B, Yu Z, Javitch JA, Hendrickson WA, Slesinger PA, Quick M, Graziano J, Yu H, Fiehn O, Clarke OB, Frank J, Fan QR | 10.1038/S41586-020-2452-0 | 2020-07-01 | Yes | |
| GABR2 | GABAB2 | GABAB | C | Human | Cryo-EM | 7C7S | - | 2.9 | B | Inactive | - | 71 | - | - | - | - | - | - |
CGP 54626A
|
small-molecule | Antagonist | - | - | No | No | Mao C, Shen C, Li C, Shen DD, Xu C, Zhang S, Zhou R, Shen Q, Chen LN, Jiang Z, Liu J, Zhang Y | 10.1038/S41422-020-0350-5 | 2020-07-01 | Yes | |
| OPSD | Rhodopsin | Opsins | A | Bovine | X-ray | 6PH7 | 6PH7_refined | 2.9 | A | Active | 100 | 94 | Gi/o | αt2 | Only H5 | 3 | - | - |
Nerol
|
small-molecule | unknown | - | - | No | No | - | - | 2020-07-01 | Yes | |
| OPSD | Rhodopsin | Opsins | A | Bovine | X-ray | 6PGS | 6PGS_refined | 2.9 | A | Active | 100 | 94 | Gi/o | αt2 | Only H5 | 3 | - | - |
Geraniol
|
small-molecule | unknown | - | - | No | No | - | - | 2020-07-01 | Yes | |
| CCR6 | CCR6 | Chemokine | A | Human | Cryo-EM | 6WWZ | 6WWZ_refined | 3.3 | R | Active | 100 | 83 | Gi/o | αo | - | 59 | - | scFv16 |
CCL20
|
peptide | Agonist | CCL20, beta-defensin 4A | peptide | No | No | Wasilko DJ, Johnson ZL, Ammirati M, Che Y, Griffor MC, Han S, Wu H | 10.1038/S41467-020-16820-6 | 2020-06-24 | Yes | |
| OPSD | Rhodopsin | Opsins | A | Bovine | X-ray | 6PEL | 6PEL_refined | 3.2 | A | Active | 100 | 93 | Gi/o | αt1 | Only H5 | 3 | - | - |
Citronellol
|
small-molecule | unknown | - | - | No | No | - | - | 2020-06-24 | Yes | |
| ADRB1 | β1 | Adrenoceptors | A | Wild turkey | Cryo-EM | 6TKO | 6TKO_refined | 3.3 | A | Active | 100 | 58 | Beta | Beta-arrestin-1 | - | 82 | - | Fab30 heavy chain Fab30 light chain |
ARFORMOTEROL
|
small-molecule | Agonist | - | - | No | No | Lee Y, Warne T, Nehme R, Pandey S, Dwivedi-Agnihotri H, Chaturvedi M, Edwards PC, Garcia-Nafria J, Leslie AGW, Shukla AK, Tate CG | 10.1038/S41586-020-2419-1 | 2020-06-17 | Yes | |
| DRD2 | D2 | Dopamine | A | Human | Cryo-EM | 6VMS | - | 3.8 | R | Active | 100 | 63 | Gi/o | αi1 | - | 64 | T4-Lysozyme | scFv16 |
bromocriptine
|
small-molecule | Agonist | dopamine | small-molecule | No | No | Yin J, Chen KM, Clark MJ, Hijazi M, Kumari P, Bai XC, Sunahara RK, Barth P, Rosenbaum DM | 10.1038/S41586-020-2379-5 | 2020-06-17 | Yes | |
| GABR2 | GABAB2 | GABAB | C | Human | Cryo-EM | 6UOA | - | 6.3 | B | Intermediate | - | 71 | - | - | - | - | - | - |
Apo (no ligand)
|
none | Apo (no ligand) | - | - | No | No | Shaye H, Ishchenko A, Lam JH, Han GW, Xue L, Rondard P, Pin JP, Katritch V, Gati C, Cherezov V | 10.1038/S41586-020-2408-4 | 2020-06-10 | Yes | |
| GABR2 | GABAB2 | GABAB | C | Human | Cryo-EM | 6VJM | - | 4.0 | B | Inactive | - | 73 | - | - | - | - | - | - |
Apo (no ligand)
|
none | Apo (no ligand) | - | - | No | No | Shaye H, Ishchenko A, Lam JH, Han GW, Xue L, Rondard P, Pin JP, Katritch V, Gati C, Cherezov V | 10.1038/S41586-020-2408-4 | 2020-06-10 | Yes | |
| GABR2 | GABAB2 | GABAB | C | Human | Cryo-EM | 6UO8 | - | 3.6 | B | Active | - | 74 | - | - | - | - | - | - |
CHEMBL112710
GS39783 |
small-molecule small-molecule |
Agonist PAM |
- | - | No | No | Shaye H, Ishchenko A, Lam JH, Han GW, Xue L, Rondard P, Pin JP, Katritch V, Gati C, Cherezov V | 10.1038/S41586-020-2408-4 | 2020-06-10 | Yes | |
| GABR2 | GABAB2 | GABAB | C | Human | Cryo-EM | 6UO9 | - | 4.8 | B | Intermediate | - | 73 | - | - | - | - | - | - |
CHEMBL112710
|
small-molecule | Agonist | - | - | No | No | Shaye H, Ishchenko A, Lam JH, Han GW, Xue L, Rondard P, Pin JP, Katritch V, Gati C, Cherezov V | 10.1038/S41586-020-2408-4 | 2020-06-10 | Yes | |
| GLR | glucagon | Glucagon | B1 | Human | Cryo-EM | 6WHC | 6WHC_refined | 3.4 | R | Active | 100 | 78 | Gs | αs | - | 56 | - | Nanobody-35 |
Dual-agonist peptide P15
|
peptide | Agonist | glucagon | peptide | No | No | Chang R, Zhang X, Qiao A, Dai A, Belousoff MJ, Tan Q, Shao L, Zhong L, Lin G, Liang YL, Ma L, Han S, Yang D, Danev R, Wang MW, Wootten D, Wu B, Sexton PM | 10.1074/JBC.RA120.013793 | 2020-05-27 | Yes | |
| MC4R | MC4 | Melanocortin | A | Human | X-ray | 6W25 | - | 2.8 | A | Intermediate | 41 | 79 | - | - | - | - | GlgA glycogen synthase | - |
SHU9119
Calcium |
peptide small-molecule |
Antagonist Cofactor |
γ-MSH, α-MSH, β-MSH, ACTH, agouti-related protein | peptide | No | No | Yu J, Gimenez LE, Hernandez CC, Wu Y, Wein AH, Han GW, McClary K, Mittal SR, Burdsall K, Stauch B, Wu L, Stevens SN, Peisley A, Williams SY, Chen V, Millhauser GL, Zhao S, Cone RD, Stevens RC | 10.1126/SCIENCE.AAZ8995 | 2020-04-29 | Yes | |
| ADA2B | α2B | Adrenoceptors | A | Human | Cryo-EM | 6K41 | - | 2.9 | R | Active | 100 | 54 | Gi/o | αo | - | 60 | T4-Lysozyme | scFv |
dexmedetomidine
|
small-molecule | Agonist | (-)-adrenaline, (-)-noradrenaline | small-molecule | No | No | Yuan D, Liu Z, Kaindl J, Maeda S, Zhao J, Sun X, Xu J, Gmeiner P, Wang HW, Kobilka BK | 10.1038/S41589-020-0492-2 | 2020-04-15 | Yes | |
| ADA2B | α2B | Adrenoceptors | A | Human | Cryo-EM | 6K42 | - | 4.1 | R | Active | 100 | 60 | Gi/o | αi1 | - | 62 | T4-Lysozyme | scFv |
dexmedetomidine
|
small-molecule | Agonist | (-)-adrenaline, (-)-noradrenaline | small-molecule | No | No | - | - | 2020-04-15 | Yes | |
| CALRL | calcitonin-like | Calcitonin | B1 | Human | Cryo-EM | 6UUS | 6UUS_refined | 2.4 | R | Active | 100 | 74 | Gs | αs | - | 48 | - | Nanobody-35 RAMP3 |
Adrenomedullin
|
peptide | Agonist | - | - | No | No | Liang YL, Belousoff MJ, Fletcher MM, Zhang X, Khoshouei M, Deganutti G, Koole C, Furness SGB, Miller LJ, Hay DL, Christopoulos A, Reynolds CA, Danev R, Wootten D, Sexton PM | 10.1021/ACSPTSCI.9B00080 | 2020-04-01 | Yes | |
| CALRL | calcitonin-like | Calcitonin | B1 | Human | Cryo-EM | 6UVA | - | 2.3 | R | Active | 100 | 75 | Gs | αs | - | 48 | - | Nanobody-35 RAMP3 |
adrenomedullin 2/intermedin
|
peptide | Agonist | - | - | No | No | Liang YL, Belousoff MJ, Fletcher MM, Zhang X, Khoshouei M, Deganutti G, Koole C, Furness SGB, Miller LJ, Hay DL, Christopoulos A, Reynolds CA, Danev R, Wootten D, Sexton PM | 10.1021/ACSPTSCI.9B00080 | 2020-04-01 | Yes | |
| GLR | glucagon | Glucagon | B1 | Human | Cryo-EM | 6LML | 6LML_refined | 3.9 | R | Active | 100 | 83 | Gi/o | αi1 | - | 63 | - | scFv16 |
glucagon
|
peptide | Agonist | glucagon | peptide | No | No | Qiao A, Han S, Li X, Li Z, Zhao P, Dai A, Chang R, Tai L, Tan Q, Chu X, Ma L, Thorsen TS, Reedtz-Runge S, Yang D, Wang MW, Sexton PM, Wootten D, Sun F, Zhao Q, Wu B | 10.1126/SCIENCE.AAZ5346 | 2020-04-01 | Yes | |
| GLR | glucagon | Glucagon | B1 | Human | Cryo-EM | 6LMK | 6LMK_refined | 3.7 | R | Active | 100 | 83 | Gs | αs | - | 59 | - | Nanobody-35 |
glucagon
|
peptide | Agonist | glucagon | peptide | No | No | Qiao A, Han S, Li X, Li Z, Zhao P, Dai A, Chang R, Tai L, Tan Q, Chu X, Ma L, Thorsen TS, Reedtz-Runge S, Yang D, Wang MW, Sexton PM, Wootten D, Sun F, Zhao Q, Wu B | 10.1126/SCIENCE.AAZ5346 | 2020-04-01 | Yes | |
| ADRB2 | β2 | Adrenoceptors | A | Human | X-ray | 6OBA | 6OBA_refined | 3.1 | A | Inactive | 0 | 68 | - | - | - | - | T4-Lysozyme | - |
CHEMBL1160734
AS408 |
small-molecule small-molecule |
Antagonist NAM |
Zn2+, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline | small-molecule | No | No | Liu X, Kaindl J, Korczynska M, Stossel A, Dengler D, Stanek M, Hubner H, Clark MJ, Mahoney J, Matt RA, Xu X, Hirata K, Shoichet BK, Sunahara RK, Kobilka BK, Gmeiner P | 10.1038/S41589-020-0549-2 | 2020-03-25 | Yes | |
| CALRL | calcitonin-like | Calcitonin | B1 | Human | Cryo-EM | 6UUN | 6UUN_refined | 3.0 | R | Active | 100 | 77 | Gs | αs | - | 48 | - | Nanobody-35 RAMP2 |
Adrenomedullin
|
peptide | Agonist | - | - | No | No | Liang YL, Belousoff MJ, Fletcher MM, Zhang X, Khoshouei M, Deganutti G, Koole C, Furness SGB, Miller LJ, Hay DL, Christopoulos A, Reynolds CA, Danev R, Wootten D, Sexton PM | 10.1021/ACSPTSCI.9B00080 | 2020-03-25 | Yes | |
| FPR2 | FPR2/ALX | Formylpeptide | A | Human | X-ray | 6LW5 | 6LW5_refined | 2.8 | A | Active | 100 | 91 | - | - | - | - | BRIL | - |
CHEMBL552527
|
protein | Agonist | PrP106-126, aspirin triggered lipoxin A4, annexin I, LL-37, aspirin-triggered resolvin D1, serum amyloid A, resolvin D1, humanin, LXA4 | peptide | No | No | Chen T, Xiong M, Zong X, Ge Y, Zhang H, Wang M, Won Han G, Yi C, Ma L, Ye RD, Xu Y, Zhao Q, Wu B | 10.1038/S41467-020-15009-1 | 2020-03-25 | Yes | |
| GLP1R | GLP-1 | Glucagon | B1 | Human | X-ray | 6LN2 | 6LN2_refined | 3.2 | A | Inactive | 0 | 83 | - | - | - | - | - | Fab7F38 light chain Fab7F38 heavy chain |
PF-06372222
|
small-molecule | NAM | glucagon-like peptide 1-(7-36) amide, glucagon, glucagon-like peptide 1-(7-37) | peptide | No | No | Wu F, Yang L, Hang K, Laursen M, Wu L, Han GW, Ren Q, Roed NK, Lin G, Hanson MA, Jiang H, Wang MW, Reedtz-Runge S, Song G, Stevens RC | 10.1038/S41467-020-14934-5 | 2020-03-18 | Yes | |
| OPRK | κ | Opioid | A | Human | X-ray | 6VI4 | 6VI4_refined | 3.3 | B | Inactive | 8 | 73 | - | - | - | - | - | Nanobody-6 |
JDTic
|
small-molecule | Antagonist | dynorphin B, dynorphin A-(1-13), dynorphin A-(1-8), β-endorphin, β-neoendorphin, α-neoendorphin, [Met]enkephalin, dynorphin A, [Leu]enkephalin, big dynorphin | peptide | No | No | Che T, English J, Krumm BE, Kim K, Pardon E, Olsen RHJ, Wang S, Zhang S, Diberto JF, Sciaky N, Carroll FI, Steyaert J, Wacker D, Roth BL | 10.1038/S41467-020-14889-7 | 2020-03-18 | Yes | |
| ACM4 | M4 | Acetylcholine (muscarinic) | A | Human | X-ray | 6KP6 | 6KP6_refined | 3.0 | A | Inactive | 3 | 59 | - | - | - | - | GlgA glycogen synthase | - |
Apo (no ligand)
|
none | Apo (no ligand) | acetylcholine | small-molecule | No | No | Wang J, Wu M, Wu L, Xu Y, Li F, Wu Y, Popov P, Wang L, Bai F, Zhao S, Liu ZJ, Hua T | 10.1107/S2052252520000597 | 2020-03-11 | Yes | |
| PACR | PAC1 | VIP and PACAP | B1 | Human | Cryo-EM | 6M1H | - | 3.6 | A | Active | 100 | 73 | Gs | αs | - | 55 | - | Nanobody-35 |
maxadilan
|
peptide | Agonist | PHM, PACAP-27, VIP, PHV, PACAP-38, PHI | peptide | No | No | Wang J, Song X, Zhang D, Chen X, Li X, Sun Y, Li C, Song Y, Ding Y, Ren R, Harrington EH, Hu LA, Zhong W, Xu C, Huang X, Wang HW, Ma Y | 10.1038/S41422-020-0280-2 | 2020-03-11 | Yes | |
| PACR | PAC1 | VIP and PACAP | B1 | Human | Cryo-EM | 6M1I | - | 3.5 | A | Active | 100 | 75 | Gs | αs | - | 57 | - | Nanobody-35 |
[Ac-His1]PACAP-27
|
peptide | Agonist | PHM, PACAP-27, VIP, PHV, PACAP-38, PHI | peptide | No | No | Wang J, Song X, Zhang D, Chen X, Li X, Sun Y, Li C, Song Y, Ding Y, Ren R, Harrington EH, Hu LA, Zhong W, Xu C, Huang X, Wang HW, Ma Y | 10.1038/S41422-020-0280-2 | 2020-03-11 | Yes | |
| PACR | PAC1 | VIP and PACAP | B1 | Human | Cryo-EM | 6LPB | 6LPB_refined | 3.9 | R | Active | 100 | 71 | Gs | αs | - | 57 | - | Nanobody-35 |
[Ac-His1]PACAP-27
|
peptide | Agonist | PHM, PACAP-27, VIP, PHV, PACAP-38, PHI | peptide | No | No | Kobayashi K, Shihoya W, Nishizawa T, Kadji FMN, Aoki J, Inoue A, Nureki O | 10.1038/S41594-020-0386-8 | 2020-03-11 | Yes | |
| DRD2 | D2 | Dopamine | A | Human | X-ray | 6LUQ | 6LUQ_refined | 3.1 | A | Inactive | 1 | 59 | - | - | - | - | T4-Lysozyme | - |
haloperidol
|
small-molecule | Antagonist | dopamine | small-molecule | No | No | Fan L, Tan L, Chen Z, Qi J, Nie F, Luo Z, Cheng J, Wang S | 10.1038/S41467-020-14884-Y | 2020-03-04 | Yes | |
| ACM2 | M2 | Acetylcholine (muscarinic) | A | Human | Cryo-EM | 6U1N | 6U1N_refined | 4.0 | R | Active | 100 | 57 | Beta | Beta-arrestin-1 | - | 86 | - | Fab30 light chain Fab30 heavy chain |
LY2119620
|
small-molecule | Agonist | acetylcholine | small-molecule | No | No | Staus DP, Hu H, Robertson MJ, Kleinhenz ALW, Wingler LM, Capel WD, Latorraca NR, Lefkowitz RJ, Skiniotis G | 10.1038/S41586-020-1954-0 | 2020-02-26 | Yes | |
| FPR2 | FPR2/ALX | Formylpeptide | A | Human | Cryo-EM | 6OMM | 6OMM_refined | 3.2 | R | Active | 100 | 85 | Gi/o | αi1 | - | 61 | - | - |
CHEMBL552527
|
protein | Agonist | PrP106-126, aspirin triggered lipoxin A4, annexin I, LL-37, aspirin-triggered resolvin D1, serum amyloid A, resolvin D1, humanin, LXA4 | peptide | No | No | Zhuang Y, Liu H, Edward Zhou X, Kumar Verma R, de Waal PW, Jang W, Xu TH, Wang L, Meng X, Zhao G, Kang Y, Melcher K, Fan H, Lambert NA, Eric Xu H, Zhang C | 10.1038/S41467-020-14728-9 | 2020-02-26 | Yes | |
| GPR52 | GPR52 | A orphans | A | Human | X-ray | 6LI1 | 6LI1_refined | 2.9 | A | Inactive | 36 | 81 | - | - | - | - | Flavodoxin | - |
Apo (no ligand)
|
none | Apo (no ligand) | - | - | No | No | Lin X, Li M, Wang N, Wu Y, Luo Z, Guo S, Han GW, Li S, Yue Y, Wei X, Xie X, Chen Y, Zhao S, Wu J, Lei M, Xu F | 10.1038/S41586-020-2019-0 | 2020-02-26 | Yes | |
| GPR52 | GPR52 | A orphans | A | Human | Cryo-EM | 6LI3 | - | 3.3 | R | Active | 100 | 79 | Gs | αs | Mini-Gs | 61 | - | Nanobody-35 |
Apo (no ligand)
|
none | Apo (no ligand) | - | - | No | No | Lin X, Li M, Wang N, Wu Y, Luo Z, Guo S, Han GW, Li S, Yue Y, Wei X, Xie X, Chen Y, Zhao S, Wu J, Lei M, Xu F | 10.1038/S41586-020-2019-0 | 2020-02-26 | Yes | |
| GPR52 | GPR52 | A orphans | A | Human | X-ray | 6LI0 | 6LI0_refined | 2.2 | A | Inactive | 36 | 81 | - | - | - | - | Flavodoxin | - |
derivative 17 [Nakahata et al., 2018]
|
small-molecule | Agonist | - | - | No | No | Lin X, Li M, Wang N, Wu Y, Luo Z, Guo S, Han GW, Li S, Yue Y, Wei X, Xie X, Chen Y, Zhao S, Wu J, Lei M, Xu F | 10.1038/S41586-020-2019-0 | 2020-02-26 | Yes | |
| GPR52 | GPR52 | A orphans | A | Human | X-ray | 6LI2 | 6LI2_refined | 2.8 | A | Inactive | 36 | 80 | - | - | - | - | Rubredoxin | - |
Apo (no ligand)
|
none | Apo (no ligand) | - | - | No | No | Lin X, Li M, Wang N, Wu Y, Luo Z, Guo S, Han GW, Li S, Yue Y, Wei X, Xie X, Chen Y, Zhao S, Wu J, Lei M, Xu F | 10.1038/S41586-020-2019-0 | 2020-02-26 | Yes | |
| NTR1 | NTS1 | Neurotensin | A | Human | Cryo-EM | 6UP7 | 6UP7_refined | 4.2 | R | Active | 100 | 77 | Beta | Beta-arrestin-1 | - | 83 | - | - |
JMV431
|
peptide | Agonist | large neurotensin, neurotensin, neuromedin N, large neuromedin N | peptide | No | No | Huang W, Masureel M, Qu Q, Janetzko J, Inoue A, Kato HE, Robertson MJ, Nguyen KC, Glenn JS, Skiniotis G, Kobilka BK | 10.1038/S41586-020-1953-1 | 2020-02-26 | Yes | |
| AGTR1 | AT1 | Angiotensin | A | Human | X-ray | 6OS1 | - | 2.8 | A | Active | 93 | 85 | - | - | - | - | BRIL | Nanobody-Nb.AT110i1_le |
TRV023
|
peptide | Agonist | angiotensin III, angiotensin IV, angiotensin A, angiotensin II | peptide | No | No | Wingler LM, Skiba MA, McMahon C, Staus DP, Kleinhenz ALW, Suomivuori CM, Latorraca NR, Dror RO, Lefkowitz RJ, Kruse AC | 10.1126/SCIENCE.AAY9813 | 2020-02-19 | Yes | |
| AGTR1 | AT1 | Angiotensin | A | Human | X-ray | 6OS2 | - | 2.7 | A | Active | 93 | 85 | - | - | - | - | BRIL | Nanobody-Nb.AT110i1_le |
TRV026
|
peptide | Agonist | angiotensin III, angiotensin IV, angiotensin A, angiotensin II | peptide | No | No | Wingler LM, Skiba MA, McMahon C, Staus DP, Kleinhenz ALW, Suomivuori CM, Latorraca NR, Dror RO, Lefkowitz RJ, Kruse AC | 10.1126/SCIENCE.AAY9813 | 2020-02-19 | Yes | |
| AGTR1 | AT1 | Angiotensin | A | Human | X-ray | 6OS0 | 6OS0_refined | 2.9 | A | Active | 93 | 85 | - | - | - | - | BRIL | Nanobody-Nb.AT110i1 |
angiotensin II
|
peptide | Agonist | angiotensin III, angiotensin IV, angiotensin A, angiotensin II | peptide | No | No | Wingler LM, Skiba MA, McMahon C, Staus DP, Kleinhenz ALW, Suomivuori CM, Latorraca NR, Dror RO, Lefkowitz RJ, Kruse AC | 10.1126/SCIENCE.AAY9813 | 2020-02-19 | Yes | |
| CNR1 | CB1 | Cannabinoid | A | Human | Cryo-EM | 6KPG | 6KPG_refined | 3.0 | R | Active | 100 | 60 | Gi/o | αi1 | - | 64 | - | scFv16 |
AM841
|
small-molecule | Agonist | 2-arachidonoylglycerol, anandamide | small-molecule | No | No | - | - | 2020-02-12 | Yes | |
| CNR2 | CB2 | Cannabinoid | A | Human | X-ray | 6KPC | 6KPC_refined | 3.2 | A | Inactive | 4 | 79 | - | - | - | - | T4-Lysozyme | - |
AM12033
|
small-molecule | Agonist | 2-arachidonoylglycerol, anandamide | small-molecule | No | No | Hua T, Li X, Wu L, Iliopoulos-Tsoutsouvas C, Wang Y, Wu M, Shen L, Brust CA, Nikas SP, Song F, Song X, Yuan S, Sun Q, Wu Y, Jiang S, Grim TW, Benchama O, Stahl EL, Zvonok N, Zhao S, Bohn LM, Makriyannis A, Liu ZJ | 10.1016/J.CELL.2020.01.008 | 2020-02-12 | Yes | |
| CNR2 | CB2 | Cannabinoid | A | Human | Cryo-EM | 6KPF | 6KPF_refined | 2.9 | R | Active | 100 | 81 | Gi/o | αi1 | - | 62 | - | scFv16 |
AM12033
|
small-molecule | Agonist | 2-arachidonoylglycerol, anandamide | small-molecule | No | No | - | - | 2020-02-12 | Yes | |
| CNR2 | CB2 | Cannabinoid | A | Human | Cryo-EM | 6PT0 | 6PT0_refined | 3.2 | R | Active | 100 | 83 | Gi/o | αi1 | - | 100 | - | scFv16 |
WIN55212-2
|
small-molecule | Agonist | 2-arachidonoylglycerol, anandamide | small-molecule | No | No | Xing C, Zhuang Y, Xu TH, Feng Z, Zhou XE, Chen M, Wang L, Meng X, Xue Y, Wang J, Liu H, McGuire TF, Zhao G, Melcher K, Zhang C, Xu HE, Xie XQ | 10.1016/J.CELL.2020.01.007 | 2020-02-12 | Yes | |
| CRFR1 | CRF1 | Corticotropin-releasing factor | B1 | Human | Cryo-EM | 6PB0 | - | 3.0 | R | Active | 100 | 68 | Gs | αs | Gs-Gi1 chimera | 58 | - | Nanobody-35 |
Urocortin
|
peptide | Agonist | urocortin 1, urocortin 2, corticotrophin-releasing hormone | peptide | No | No | Ma S, Shen Q, Zhao LH, Mao C, Zhou XE, Shen DD, de Waal PW, Bi P, Li C, Jiang Y, Wang MW, Sexton PM, Wootten D, Melcher K, Zhang Y, Xu HE | 10.1016/J.MOLCEL.2020.01.013 | 2020-02-12 | Yes | |
| CRFR2 | CRF2 | Corticotropin-releasing factor | B1 | Human | Cryo-EM | 6PB1 | 6PB1_refined | 2.8 | P | Active | 100 | 68 | Gs | αs | - | 58 | - | Nanobody-35 |
Urocortin
|
peptide | Agonist | urocortin 1, urocortin 3, urocortin 2, corticotrophin-releasing hormone | peptide | No | No | Ma S, Shen Q, Zhao LH, Mao C, Zhou XE, Shen DD, de Waal PW, Bi P, Li C, Jiang Y, Wang MW, Sexton PM, Wootten D, Melcher K, Zhang Y, Xu HE | 10.1016/J.MOLCEL.2020.01.013 | 2020-02-12 | Yes | |
| EDNRB | ETB | Endothelin | A | Human | X-ray | 6LRY | 6LRY_refined | 3.0 | A | Inactive | 16 | 70 | - | - | - | - | T4-Lysozyme | - |
sarafotoxin S6b
|
peptide | Agonist | endothelin-2, endothelin-3, endothelin-1 | peptide | No | No | Izume T, Miyauchi H, Shihoya W, Nureki O | 10.1016/J.BBRC.2019.12.091 | 2020-02-12 | Yes | |
| OPSD | Rhodopsin | Opsins | A | Bovine | X-ray | 6NWE | 6NWE_refined | 2.7 | A | Active | 100 | 94 | Gi/o | αt1 | Only H5 | 3 | - | - |
B-Octylglucoside
|
small-molecule | unknown | - | - | No | No | - | - | 2020-02-12 | Yes | |
| CRFR1 | CRF1 | Corticotropin-releasing factor | B1 | Human | Cryo-EM | 6P9X | - | 2.9 | R | Active | 100 | 65 | Gs | αs | - | 49 | - | Nanobody-35 |
Corticoliberin
|
peptide | Agonist | urocortin 1, urocortin 2, corticotrophin-releasing hormone | peptide | No | No | Liang YL, Belousoff MJ, Zhao P, Koole C, Fletcher MM, Truong TT, Julita V, Christopoulos G, Xu HE, Zhang Y, Khoshouei M, Christopoulos A, Danev R, Sexton PM, Wootten D | 10.1016/J.MOLCEL.2020.01.012 | 2020-02-05 | Yes | |
| PACR | PAC1 | VIP and PACAP | B1 | Human | Cryo-EM | 6P9Y | - | 3.0 | R | Active | 100 | 55 | Gs | αs | - | 49 | - | Nanobody-35 |
[Ac-His1]PACAP-27
|
peptide | Agonist | PHM, PACAP-27, VIP, PHV, PACAP-38, PHI | peptide | No | No | Liang YL, Belousoff MJ, Zhao P, Koole C, Fletcher MM, Truong TT, Julita V, Christopoulos G, Xu HE, Zhang Y, Khoshouei M, Christopoulos A, Danev R, Sexton PM, Wootten D | 10.1016/J.MOLCEL.2020.01.012 | 2020-02-05 | Yes | |
| APJ | apelin | Apelin | A | Human | X-ray | 6KNM | 6KNM_refined | 3.2 | B | Inactive | 8 | 78 | - | - | - | - | Rubredoxin | - |
Single domain antibody JN241
|
protein | Agonist | apelin-13, apelin-36, apelin-17, Elabela/Toddler-21, Elabela/Toddler-32, Elabela/Toddler-11, apelin receptor early endogenous ligand, [Pyr1]apelin-13 | peptide | No | No | Ma Y, Ding Y, Song X, Ma X, Li X, Zhang N, Song Y, Sun Y, Shen Y, Zhong W, Hu LA, Ma Y, Zhang MY | 10.1126/SCIADV.AAX7379 | 2020-01-29 | Yes | |
| AGTR2 | AT2 | Angiotensin | A | Human | X-ray | 6JOD | 6JOD_refined | 3.2 | A | Active | 100 | 84 | - | - | - | - | BRIL | Heavy chain of 4A03Fab Light chain of 4A03Fab |
angiotensin II
|
peptide | Agonist | angiotensin III, angiotensin-(1-7), angiotensin II | peptide | No | No | Asada H, Inoue A, Ngako Kadji FM, Hirata K, Shiimura Y, Im D, Shimamura T, Nomura N, Iwanari H, Hamakubo T, Kusano-Arai O, Hisano H, Uemura T, Suno C, Aoki J, Iwata S | 10.1016/J.STR.2019.12.003 | 2020-01-15 | Yes | |
| OX1R | OX1 | Orexin | A | Human | X-ray | 6TOS | 6TOS_refined | 2.1 | B | Inactive | 1 | 72 | - | - | - | - | - | - |
CHEMBL2413522
|
small-molecule | Antagonist | orexin-B, orexin-A | peptide | No | No | Rappas M, Ali AAE, Bennett KA, Brown JD, Bucknell SJ, Congreve M, Cooke RM, Cseke G, de Graaf C, Doré AS, Errey JC, Jazayeri A, Marshall FH, Mason JS, Mould R, Patel JC, Tehan BG, Weir M, Christopher JA. | 10.1021/acs.jmedchem.9b01787 | 2020-01-15 | Yes | |
| OX1R | OX1 | Orexin | A | Human | X-ray | 6TOT | 6TOT_refined | 2.2 | B | Inactive | 1 | 71 | - | - | - | - | - | - |
lemborexant
|
small-molecule | Antagonist | orexin-B, orexin-A | peptide | No | No | Rappas M, Ali AAE, Bennett KA, Brown JD, Bucknell SJ, Congreve M, Cooke RM, Cseke G, de Graaf C, Doré AS, Errey JC, Jazayeri A, Marshall FH, Mason JS, Mould R, Patel JC, Tehan BG, Weir M, Christopher JA. | 10.1021/acs.jmedchem.9b01787 | 2020-01-15 | Yes | |
| GLP1R | GLP-1 | Glucagon | B1 | Human | Cryo-EM | 6ORV | 6ORV_refined | 3.0 | E | Active | 100 | 61 | Gs | αs | - | 49 | - | Nanobody-35 |
CHEMBL3950796
|
small-molecule | Agonist | glucagon-like peptide 1-(7-36) amide, glucagon, glucagon-like peptide 1-(7-37) | peptide | No | No | Zhao P, Liang YL, Belousoff MJ, Deganutti G, Fletcher MM, Willard FS, Bell MG, Christe ME, Sloop KW, Inoue A, Truong TT, Clydesdale L, Furness SGB, Christopoulos A, Wang MW, Miller LJ, Reynolds CA, Danev R, Sexton PM, Wootten D | 10.1038/s41586-019-1902-z | 2020-01-08 | Yes | |
| OX1R | OX1 | Orexin | A | Human | X-ray | 6TQ7 | 6TQ7_refined | 2.7 | A | Inactive | 1 | 71 | - | - | - | - | - | - |
SB-334867
|
small-molecule | Antagonist | orexin-B, orexin-A | peptide | No | No | Rappas M, Ali AAE, Bennett KA, Brown JD, Bucknell SJ, Congreve M, Cooke RM, Cseke G, de Graaf C, Doré AS, Errey JC, Jazayeri A, Marshall FH, Mason JS, Mould R, Patel JC, Tehan BG, Weir M, Christopher JA. | 10.1021/acs.jmedchem.9b01787 | 2020-01-01 | Yes | |
| OX1R | OX1 | Orexin | A | Human | X-ray | 6TP4 | - | 3.0 | A | Inactive | 1 | 70 | - | - | - | - | - | - |
ACT-462206
|
small-molecule | Antagonist | orexin-B, orexin-A | peptide | No | No | Rappas M, Ali AAE, Bennett KA, Brown JD, Bucknell SJ, Congreve M, Cooke RM, Cseke G, de Graaf C, Doré AS, Errey JC, Jazayeri A, Marshall FH, Mason JS, Mould R, Patel JC, Tehan BG, Weir M, Christopher JA. | 10.1021/acs.jmedchem.9b01787 | 2020-01-01 | Yes | |
| OX1R | OX1 | Orexin | A | Human | X-ray | 6TOD | - | 2.1 | A | Inactive | 1 | 71 | - | - | - | - | - | - |
EMPA
|
small-molecule | Antagonist | orexin-B, orexin-A | peptide | No | No | Rappas M, Ali AAE, Bennett KA, Brown JD, Bucknell SJ, Congreve M, Cooke RM, Cseke G, de Graaf C, Doré AS, Errey JC, Jazayeri A, Marshall FH, Mason JS, Mould R, Patel JC, Tehan BG, Weir M, Christopher JA. | 10.1021/acs.jmedchem.9b01787 | 2020-01-01 | Yes | |
| OX1R | OX1 | Orexin | A | Human | X-ray | 6TQ6 | 6TQ6_refined | 2.6 | B | Inactive | 1 | 71 | - | - | - | - | - | - |
CHEMBL4592653
|
small-molecule | Antagonist | orexin-B, orexin-A | peptide | No | No | Rappas M, Ali AAE, Bennett KA, Brown JD, Bucknell SJ, Congreve M, Cooke RM, Cseke G, de Graaf C, Doré AS, Errey JC, Jazayeri A, Marshall FH, Mason JS, Mould R, Patel JC, Tehan BG, Weir M, Christopher JA. | 10.1021/acs.jmedchem.9b01787 | 2020-01-01 | Yes | |
| OX1R | OX1 | Orexin | A | Human | X-ray | 6TQ9 | 6TQ9_refined | 2.7 | B | Inactive | 1 | 71 | - | - | - | - | - | - |
SB-408124
|
small-molecule | Antagonist | orexin-B, orexin-A | peptide | No | No | Rappas M, Ali AAE, Bennett KA, Brown JD, Bucknell SJ, Congreve M, Cooke RM, Cseke G, de Graaf C, Doré AS, Errey JC, Jazayeri A, Marshall FH, Mason JS, Mould R, Patel JC, Tehan BG, Weir M, Christopher JA. | 10.1021/acs.jmedchem.9b01787 | 2020-01-01 | Yes | |
| OX1R | OX1 | Orexin | A | Human | X-ray | 6TP6 | 6TP6_refined | 2.3 | B | Inactive | 1 | 71 | - | - | - | - | - | - |
filorexant
|
small-molecule | Antagonist | orexin-B, orexin-A | peptide | No | No | Rappas M, Ali AAE, Bennett KA, Brown JD, Bucknell SJ, Congreve M, Cooke RM, Cseke G, de Graaf C, Doré AS, Errey JC, Jazayeri A, Marshall FH, Mason JS, Mould R, Patel JC, Tehan BG, Weir M, Christopher JA. | 10.1021/acs.jmedchem.9b01787 | 2020-01-01 | Yes | |
| OX1R | OX1 | Orexin | A | Human | X-ray | 6TQ4 | 6TQ4_refined | 2.3 | B | Inactive | 1 | 70 | - | - | - | - | - | - |
CHEMBL4590386
|
small-molecule | Antagonist | orexin-B, orexin-A | peptide | No | No | Rappas M, Ali AAE, Bennett KA, Brown JD, Bucknell SJ, Congreve M, Cooke RM, Cseke G, de Graaf C, Doré AS, Errey JC, Jazayeri A, Marshall FH, Mason JS, Mould R, Patel JC, Tehan BG, Weir M, Christopher JA. | 10.1021/acs.jmedchem.9b01787 | 2020-01-01 | Yes | |
| OX1R | OX1 | Orexin | A | Human | X-ray | 6TO7 | - | 2.3 | A | Inactive | 1 | 71 | - | - | - | - | - | - |
suvorexant
|
small-molecule | Antagonist | orexin-B, orexin-A | peptide | No | No | Rappas M, Ali AAE, Bennett KA, Brown JD, Bucknell SJ, Congreve M, Cooke RM, Cseke G, de Graaf C, Doré AS, Errey JC, Jazayeri A, Marshall FH, Mason JS, Mould R, Patel JC, Tehan BG, Weir M, Christopher JA. | 10.1021/acs.jmedchem.9b01787 | 2020-01-01 | Yes | |
| OX1R | OX1 | Orexin | A | Human | X-ray | 6TP3 | 6TP3_refined | 3.0 | A | Inactive | 1 | 74 | - | - | - | - | - | - |
daridorexant
|
small-molecule | Antagonist | orexin-B, orexin-A | peptide | No | No | Rappas M, Ali AAE, Bennett KA, Brown JD, Bucknell SJ, Congreve M, Cooke RM, Cseke G, de Graaf C, Doré AS, Errey JC, Jazayeri A, Marshall FH, Mason JS, Mould R, Patel JC, Tehan BG, Weir M, Christopher JA. | 10.1021/acs.jmedchem.9b01787 | 2020-01-01 | Yes | |
| OX2R | OX2 | Orexin | A | Human | X-ray | 6TPG | 6TPG_refined | 2.7 | A | Inactive | 1 | 69 | - | - | - | - | GlgA glycogen synthase | - |
EMPA
|
small-molecule | Antagonist | orexin-B, orexin-A | peptide | No | No | Rappas M, Ali AAE, Bennett KA, Brown JD, Bucknell SJ, Congreve M, Cooke RM, Cseke G, de Graaf C, Doré AS, Errey JC, Jazayeri A, Marshall FH, Mason JS, Mould R, Patel JC, Tehan BG, Weir M, Christopher JA. | 10.1021/acs.jmedchem.9b01787 | 2020-01-01 | Yes | |
| OX2R | OX2 | Orexin | A | Human | X-ray | 6TPN | 6TPN_refined | 2.6 | A | Inactive | 1 | 71 | - | - | - | - | GlgA glycogen synthase | - |
HTL6641
|
small-molecule | Antagonist | orexin-B, orexin-A | peptide | No | No | Rappas M, Ali AAE, Bennett KA, Brown JD, Bucknell SJ, Congreve M, Cooke RM, Cseke G, de Graaf C, Doré AS, Errey JC, Jazayeri A, Marshall FH, Mason JS, Mould R, Patel JC, Tehan BG, Weir M, Christopher JA. | 10.1021/acs.jmedchem.9b01787 | 2020-01-01 | Yes | |
| OX2R | OX2 | Orexin | A | Human | X-ray | 6TPJ | 6TPJ_refined | 2.7 | A | Inactive | 1 | 68 | - | - | - | - | GlgA glycogen synthase | - |
suvorexant
|
small-molecule | Antagonist | orexin-B, orexin-A | peptide | No | No | Rappas M, Ali AAE, Bennett KA, Brown JD, Bucknell SJ, Congreve M, Cooke RM, Cseke G, de Graaf C, Doré AS, Errey JC, Jazayeri A, Marshall FH, Mason JS, Mould R, Patel JC, Tehan BG, Weir M, Christopher JA. | 10.1021/acs.jmedchem.9b01787 | 2020-01-01 | Yes | |
| ACM5 | M5 | Acetylcholine (muscarinic) | A | Human | X-ray | 6OL9 | 6OL9_refined | 2.5 | A | Inactive | 3 | 53 | - | - | - | - | T4-Lysozyme | - |
tiotropium
|
small-molecule | Inverse agonist | acetylcholine | small-molecule | No | No | Vuckovic Z, Gentry PR, Berizzi AE, Hirata K, Varghese S, Thompson G, van der Westhuizen ET, Burger WAC, Rahmani R, Valant C, Langmead CJ, Lindsley CW, Baell JB, Tobin AB, Sexton PM, Christopoulos A, Thal DM | 10.1073/PNAS.1914446116 | 2019-12-11 | Yes | |
| CLTR2 | CysLT2 | Leukotriene | A | Human | X-ray | 6RZ7 | 6RZ7_refined | 2.4 | A | Active | 56 | 79 | - | - | - | - | BRIL | - |
ONO-2570366
|
small-molecule | Antagonist | LTC4, LTE4, LTD4 | small-molecule | No | No | Gusach A, Luginina A, Marin E, Brouillette RL, Besserer-Offroy E, Longpre JM, Ishchenko A, Popov P, Patel N, Fujimoto T, Maruyama T, Stauch B, Ergasheva M, Romanovskaia D, Stepko A, Kovalev K, Shevtsov M, Gordeliy V, Han GW, Katritch V, Borshchevskiy V, Sarret P, Mishin A, Cherezov V | 10.1038/S41467-019-13348-2 | 2019-12-11 | Yes | |
| CLTR2 | CysLT2 | Leukotriene | A | Human | X-ray | 6RZ6 | 6RZ6_refined | 2.4 | A | Active | 56 | 82 | - | - | - | - | BRIL | - |
ONO-2570366
|
small-molecule | Antagonist | LTC4, LTE4, LTD4 | small-molecule | No | No | Gusach A, Luginina A, Marin E, Brouillette RL, Besserer-Offroy E, Longpre JM, Ishchenko A, Popov P, Patel N, Fujimoto T, Maruyama T, Stauch B, Ergasheva M, Romanovskaia D, Stepko A, Kovalev K, Shevtsov M, Gordeliy V, Han GW, Katritch V, Borshchevskiy V, Sarret P, Mishin A, Cherezov V | 10.1038/S41467-019-13348-2 | 2019-12-11 | Yes | |
| CLTR2 | CysLT2 | Leukotriene | A | Human | X-ray | 6RZ8 | 6RZ8_refined | 2.7 | A | Active | 56 | 78 | - | - | - | - | BRIL | - |
ONO-2080365
|
small-molecule | Antagonist | LTC4, LTE4, LTD4 | small-molecule | No | No | Gusach A, Luginina A, Marin E, Brouillette RL, Besserer-Offroy E, Longpre JM, Ishchenko A, Popov P, Patel N, Fujimoto T, Maruyama T, Stauch B, Ergasheva M, Romanovskaia D, Stepko A, Kovalev K, Shevtsov M, Gordeliy V, Han GW, Katritch V, Borshchevskiy V, Sarret P, Mishin A, Cherezov V | 10.1038/S41467-019-13348-2 | 2019-12-11 | Yes | |
| CLTR2 | CysLT2 | Leukotriene | A | Human | X-ray | 6RZ9 | 6RZ9_refined | 2.7 | A | Active | 56 | 81 | - | - | - | - | BRIL | - |
ONO-2770372
|
small-molecule | Antagonist | LTC4, LTE4, LTD4 | small-molecule | No | No | Gusach A, Luginina A, Marin E, Brouillette RL, Besserer-Offroy E, Longpre JM, Ishchenko A, Popov P, Patel N, Fujimoto T, Maruyama T, Stauch B, Ergasheva M, Romanovskaia D, Stepko A, Kovalev K, Shevtsov M, Gordeliy V, Han GW, Katritch V, Borshchevskiy V, Sarret P, Mishin A, Cherezov V | 10.1038/S41467-019-13348-2 | 2019-12-11 | Yes | |
| OPRD | δ | Opioid | A | Human | X-ray | 6PT2 | 6PT2_refined | 2.8 | A | Active | 69 | 78 | - | - | - | - | BRIL | - |
KGCHM07
|
peptide | Agonist | dynorphin B, dynorphin A-(1-13), dynorphin A-(1-8), β-endorphin, α-neoendorphin, [Met]enkephalin, dynorphin A, [Leu]enkephalin, endomorphin-1 | peptide | No | No | Claff T, Yu J, Blais V, Patel N, Martin C, Wu L, Han GW, Holleran BJ, Van der Poorten O, White KL, Hanson MA, Sarret P, Gendron L, Cherezov V, Katritch V, Ballet S, Liu ZJ, Muller CE, Stevens RC | 10.1126/SCIADV.AAX9115 | 2019-12-11 | Yes | |
| OPRD | δ | Opioid | A | Human | X-ray | 6PT3 | 6PT3_refined | 3.3 | A | Active | 69 | 78 | - | - | - | - | BRIL | - |
DPI-287
|
small-molecule | Agonist | dynorphin B, dynorphin A-(1-13), dynorphin A-(1-8), β-endorphin, α-neoendorphin, [Met]enkephalin, dynorphin A, [Leu]enkephalin, endomorphin-1 | peptide | No | No | Claff T, Yu J, Blais V, Patel N, Martin C, Wu L, Han GW, Holleran BJ, Van der Poorten O, White KL, Hanson MA, Sarret P, Gendron L, Cherezov V, Katritch V, Ballet S, Liu ZJ, Muller CE, Stevens RC | 10.1126/SCIADV.AAX9115 | 2019-12-11 | Yes | |
| ADA2A | α2A | Adrenoceptors | A | Human | X-ray | 6KUX | 6KUX_refined | 2.7 | A | Inactive | 1 | 57 | - | - | - | - | BRIL | - |
RS79948
|
small-molecule | Antagonist | (-)-adrenaline, (-)-noradrenaline | small-molecule | No | No | - | - | 2019-12-04 | Yes | |
| ADA2A | α2A | Adrenoceptors | A | Human | X-ray | 6KUY | 6KUY_refined | 3.2 | A | Inactive | 1 | 56 | - | - | - | - | BRIL | - |
(2~{S})-4-fluoranyl-2-(1~{H}-imidazol-5-yl)-1-propan-2-yl-2,3-dihydroindole
|
small-molecule | Agonist (partial) | (-)-adrenaline, (-)-noradrenaline | small-molecule | No | No | - | - | 2019-12-04 | Yes | |
| ADA2C | α2C | Adrenoceptors | A | Human | X-ray | 6KUW | 6KUW_refined | 2.8 | A | Inactive | 1 | 60 | - | - | - | - | GlgA glycogen synthase | - |
(8Ar,12aS,13aR)-12-ethylsulfonyl-3-methoxy-5,6,8,8a,9,10,11,12a,13,13a-decahydroisoquinolino[2,1-g][1,6]naphthyridine
|
small-molecule | Antagonist | (-)-adrenaline, (-)-noradrenaline | small-molecule | No | No | - | - | 2019-12-04 | Yes | |
| DRD4 | D4 | Dopamine | A | Mouse | X-ray | 6IQL | 6IQL_refined | 3.5 | A | Inactive | 16 | 65 | - | - | - | - | BRIL | - |
L745870
|
small-molecule | Antagonist | - | - | No | No | Zhou Y, Cao C, He L, Wang X, Zhang XC | 10.7554/ELIFE.48822 | 2019-12-04 | Yes | |
| NTR1 | NTS1 | Neurotensin | A | Human | Cryo-EM | 6PWC | 6PWC_refined | 4.9 | R | Active | 100 | 77 | Beta | Beta-arrestin-1 | - | 84 | - | Fab30 heavy chain Fab30 light chain |
CHEMBL48981
|
protein | Agonist | large neurotensin, neurotensin, neuromedin N, large neuromedin N | peptide | No | No | Yin W, Li Z, Jin M, Yin YL, de Waal PW, Pal K, Yin Y, Gao X, He Y, Gao J, Wang X, Zhang Y, Zhou H, Melcher K, Jiang Y, Cong Y, Edward Zhou X, Yu X, Eric Xu H | 10.1038/S41422-019-0256-2 | 2019-12-04 | Yes | |
| ADRB2 | β2 | Adrenoceptors | A | Human | Cryo-EM | 6NI3 | 6NI3_refined | 3.8 | R | Active | 100 | 69 | Gs | αs | - | 59 | - | Nanobody-35 |
CHEMBL1615159
|
small-molecule | Agonist | Zn2+, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline | small-molecule | No | No | Nguyen AH, Thomsen ARB, Cahill TJ 3rd, Huang R, Huang LY, Marcink T, Clarke OB, Heissel S, Masoudi A, Ben-Hail D, Samaan F, Dandey VP, Tan YZ, Hong C, Mahoney JP, Triest S, Little J 4th, Chen X, Sunahara R, Steyaert J, Molina H, Yu Z, des Georges A, Lefkowitz RJ | 10.1038/S41594-019-0330-Y | 2019-11-20 | Yes | |
| AA2AR | A2A | Adenosine | A | Human | X-ray | 6PS7 | 6PS7_refined | 1.9 | A | Inactive | 1 | 72 | - | - | - | - | BRIL | - |
ZM-241385
|
small-molecule | Antagonist | adenosine | small-molecule | No | No | Ishchenko A, Stauch B, Han GW, Batyuk A, Shiriaeva A, Li C, Zatsepin N, Weierstall U, Liu W, Nango E, Nakane T, Tanaka R, Tono K, Joti Y, Iwata S, Moraes I, Gati C, Cherezov V | 10.1107/S2052252519013137 | 2019-11-13 | Yes | |
| ADRB2 | β2 | Adrenoceptors | A | Human | X-ray | 6PS5 | 6PS5_refined | 2.9 | A | Inactive | 0 | 68 | - | - | - | - | T4-Lysozyme | - |
(-)-propranolol
|
small-molecule | Antagonist | Zn2+, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline | small-molecule | No | No | Ishchenko A, Stauch B, Han GW, Batyuk A, Shiriaeva A, Li C, Zatsepin N, Weierstall U, Liu W, Nango E, Nakane T, Tanaka R, Tono K, Joti Y, Iwata S, Moraes I, Gati C, Cherezov V | 10.1107/S2052252519013137 | 2019-11-13 | Yes | |
| ADRB2 | β2 | Adrenoceptors | A | Human | X-ray | 6PS2 | 6PS2_refined | 2.4 | A | Inactive | 0 | 68 | - | - | - | - | T4-Lysozyme | - |
CHEMBL1160734
|
small-molecule | Antagonist | Zn2+, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline | small-molecule | No | No | Ishchenko A, Stauch B, Han GW, Batyuk A, Shiriaeva A, Li C, Zatsepin N, Weierstall U, Liu W, Nango E, Nakane T, Tanaka R, Tono K, Joti Y, Iwata S, Moraes I, Gati C, Cherezov V | 10.1107/S2052252519013137 | 2019-11-13 | Yes | |
| ADRB2 | β2 | Adrenoceptors | A | Human | X-ray | 6PS4 | 6PS4_refined | 2.6 | A | Inactive | 0 | 68 | - | - | - | - | T4-Lysozyme | - |
ICI 118551
|
small-molecule | Antagonist | Zn2+, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline | small-molecule | No | No | Ishchenko A, Stauch B, Han GW, Batyuk A, Shiriaeva A, Li C, Zatsepin N, Weierstall U, Liu W, Nango E, Nakane T, Tanaka R, Tono K, Joti Y, Iwata S, Moraes I, Gati C, Cherezov V | 10.1107/S2052252519013137 | 2019-11-13 | Yes | |
| ADRB2 | β2 | Adrenoceptors | A | Human | X-ray | 6PS0 | 6PS0_refined | 3.4 | A | Inactive | 0 | 68 | - | - | - | - | T4-Lysozyme | - |
carazolol
|
small-molecule | Antagonist | Zn2+, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline | small-molecule | No | No | Ishchenko A, Stauch B, Han GW, Batyuk A, Shiriaeva A, Li C, Zatsepin N, Weierstall U, Liu W, Nango E, Nakane T, Tanaka R, Tono K, Joti Y, Iwata S, Moraes I, Gati C, Cherezov V | 10.1107/S2052252519013137 | 2019-11-13 | Yes | |
| ADRB2 | β2 | Adrenoceptors | A | Human | X-ray | 6PRZ | 6PRZ_refined | 2.8 | A | Inactive | 0 | 68 | - | - | - | - | T4-Lysozyme | - |
CHEMBL1160734
|
small-molecule | Antagonist | Zn2+, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline | small-molecule | No | No | Ishchenko A, Stauch B, Han GW, Batyuk A, Shiriaeva A, Li C, Zatsepin N, Weierstall U, Liu W, Nango E, Nakane T, Tanaka R, Tono K, Joti Y, Iwata S, Moraes I, Gati C, Cherezov V | 10.1107/S2052252519013137 | 2019-11-13 | Yes | |
| ADRB2 | β2 | Adrenoceptors | A | Human | X-ray | 6PS3 | 6PS3_refined | 2.5 | A | Inactive | 0 | 68 | - | - | - | - | T4-Lysozyme | - |
CHEMBL3799125
|
small-molecule | Antagonist | Zn2+, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline | small-molecule | No | No | Ishchenko A, Stauch B, Han GW, Batyuk A, Shiriaeva A, Li C, Zatsepin N, Weierstall U, Liu W, Nango E, Nakane T, Tanaka R, Tono K, Joti Y, Iwata S, Moraes I, Gati C, Cherezov V | 10.1107/S2052252519013137 | 2019-11-13 | Yes | |
| ADRB2 | β2 | Adrenoceptors | A | Human | X-ray | 6PS6 | 6PS6_refined | 2.7 | A | Inactive | 0 | 68 | - | - | - | - | T4-Lysozyme | - |
timolol
|
small-molecule | Antagonist | Zn2+, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline | small-molecule | No | No | Ishchenko A, Stauch B, Han GW, Batyuk A, Shiriaeva A, Li C, Zatsepin N, Weierstall U, Liu W, Nango E, Nakane T, Tanaka R, Tono K, Joti Y, Iwata S, Moraes I, Gati C, Cherezov V | 10.1107/S2052252519013137 | 2019-11-13 | Yes | |
| ADRB2 | β2 | Adrenoceptors | A | Human | X-ray | 6PS1 | 6PS1_refined | 3.2 | A | Inactive | 0 | 68 | - | - | - | - | T4-Lysozyme | - |
timolol
|
small-molecule | Antagonist | Zn2+, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline | small-molecule | No | No | Ishchenko A, Stauch B, Han GW, Batyuk A, Shiriaeva A, Li C, Zatsepin N, Weierstall U, Liu W, Nango E, Nakane T, Tanaka R, Tono K, Joti Y, Iwata S, Moraes I, Gati C, Cherezov V | 10.1107/S2052252519013137 | 2019-11-13 | Yes | |
| GLP1R | GLP-1 | Glucagon | B1 | Human | X-ray | 6KK1 | 6KK1_refined | 2.8 | B | Inactive | 0 | 57 | - | - | - | - | T4-Lysozyme | - |
PF-06372222
|
small-molecule | NAM | glucagon-like peptide 1-(7-36) amide, glucagon, glucagon-like peptide 1-(7-37) | peptide | No | No | - | - | 2019-11-13 | Yes | |
| GLP1R | GLP-1 | Glucagon | B1 | Human | X-ray | 6KJV | 6KJV_refined | 2.8 | B | Inactive | 0 | 57 | - | - | - | - | T4-Lysozyme | - |
PF-06372222
|
small-molecule | NAM | glucagon-like peptide 1-(7-36) amide, glucagon, glucagon-like peptide 1-(7-37) | peptide | No | No | Xu Y, Wang Y, Wang Y, Liu K, Peng Y, Yao D, Tao H, Liu H, Song G | 10.1107/S2052252519013496 | 2019-11-13 | Yes | |
| GLP1R | GLP-1 | Glucagon | B1 | Human | X-ray | 6KK7 | 6KK7_refined | 3.1 | B | Inactive | 0 | 56 | - | - | - | - | T4-Lysozyme | - |
PF-06372222
|
small-molecule | NAM | glucagon-like peptide 1-(7-36) amide, glucagon, glucagon-like peptide 1-(7-37) | peptide | No | No | Xu Y, Wang Y, Wang Y, Liu K, Peng Y, Yao D, Tao H, Liu H, Song G | 10.1107/S2052252519013496 | 2019-11-13 | Yes | |
| MTR1A | MT1 | Melatonin | A | Human | X-ray | 6PS8 | 6PS8_refined | 3.3 | A | Inactive | 1 | 83 | - | - | - | - | GlgA glycogen synthase | - |
CHEMBL15060
|
small-molecule | Agonist | melatonin | small-molecule | No | No | Ishchenko A, Stauch B, Han GW, Batyuk A, Shiriaeva A, Li C, Zatsepin N, Weierstall U, Liu W, Nango E, Nakane T, Tanaka R, Tono K, Joti Y, Iwata S, Moraes I, Gati C, Cherezov V | 10.1107/S2052252519013137 | 2019-11-13 | Yes | |
| AA2AR | A2A | Adenosine | A | Human | X-ray | 6JZH | 6JZH_refined | 2.3 | A | Inactive | 1 | 72 | - | - | - | - | BRIL | - |
ZM-241385
|
small-molecule | Antagonist | adenosine | small-molecule | No | No | Shimazu Y, Tono K, Tanaka T, Yamanaka Y, Nakane T, Mori C, Terakado Kimura K, Fujiwara T, Sugahara M, Tanaka R, Doak RB, Shimamura T, Iwata S, Nango E, Yabashi M | 10.1107/S1600576719012846 | 2019-10-30 | Yes | |
| CLTR1 | CysLT1 | Leukotriene | A | Human | X-ray | 6RZ4 | 6RZ4_refined | 2.7 | A | Active | 56 | 85 | - | - | - | - | BRIL | - |
pranlukast
|
small-molecule | Antagonist | LTC4, LTE4, LTD4 | small-molecule | No | No | Luginina A, Gusach A, Marin E, Mishin A, Brouillette R, Popov P, Shiriaeva A, Besserer-Offroy E, Longpre JM, Lyapina E, Ishchenko A, Patel N, Polovinkin V, Safronova N, Bogorodskiy A, Edelweiss E, Hu H, Weierstall U, Liu W, Batyuk A, Gordeliy V, Han GW, Sarret P, Katritch V, Borshchevskiy V, Cherezov V | 10.1126/SCIADV.AAX2518 | 2019-10-30 | Yes | |
| CLTR1 | CysLT1 | Leukotriene | A | Human | X-ray | 6RZ5 | 6RZ5_refined | 2.5 | B | Active | 56 | 84 | - | - | - | - | BRIL | - |
zafirlukast
|
small-molecule | Antagonist | LTC4, LTE4, LTD4 | small-molecule | No | No | Luginina A, Gusach A, Marin E, Mishin A, Brouillette R, Popov P, Shiriaeva A, Besserer-Offroy E, Longpre JM, Lyapina E, Ishchenko A, Patel N, Polovinkin V, Safronova N, Bogorodskiy A, Edelweiss E, Hu H, Weierstall U, Liu W, Batyuk A, Gordeliy V, Han GW, Sarret P, Katritch V, Borshchevskiy V, Cherezov V | 10.1126/SCIADV.AAX2518 | 2019-10-30 | Yes | |
| CNR1 | CB1 | Cannabinoid | A | Human | X-ray | 6KQI | 6KQI_refined | 3.3 | A | Inactive | 7 | 60 | - | - | - | - | GlgA glycogen synthase | - |
CP55940
Org27569 |
small-molecule small-molecule |
Agonist NAM |
2-arachidonoylglycerol, anandamide | small-molecule | No | No | Shao Z, Yan W, Chapman K, Ramesh K, Ferrell AJ, Yin J, Wang X, Xu Q, Rosenbaum DM | 10.1038/S41589-019-0387-2 | 2019-10-23 | Yes | |
| CCR7 | CCR7 | Chemokine | A | Human | X-ray | 6QZH | 6QZH_refined | 2.1 | A | Inactive | 5 | 71 | - | - | - | - | Sialidase NanA | - |
CHEMBL5433301
|
small-molecule | Allosteric antagonist | CCL21, CCL19 | peptide | No | No | Jaeger K, Bruenle S, Weinert T, Guba W, Muehle J, Miyazaki T, Weber M, Furrer A, Haenggi N, Tetaz T, Huang CY, Mattle D, Vonach JM, Gast A, Kuglstatter A, Rudolph MG, Nogly P, Benz J, Dawson RJP, Standfuss J | 10.1016/J.CELL.2019.07.028 | 2019-09-04 | Yes | |
| OPSD | Rhodopsin | Opsins | A | Bovine | Cryo-EM | 6OFJ | 6OFJ_refined | 4.5 | A | Inactive | 24 | 93 | - | - | - | - | - | - |
Apo (no ligand)
|
none | Apo (no ligand) | - | - | No | No | Zhao DY, Poge M, Morizumi T, Gulati S, Van Eps N, Zhang J, Miszta P, Filipek S, Mahamid J, Plitzko JM, Baumeister W, Ernst OP, Palczewski K | 10.1074/JBC.RA119.010089 | 2019-08-21 | Yes | |
| SUCR1 | succinate | Succinate | A | Rat | X-ray | 6IBB | 6IBB_refined | 2.1 | A | Active | 56 | 93 | - | - | - | - | - | Nanobody-6 |
Apo (no ligand)
|
none | Apo (no ligand) | - | - | No | No | Haffke M, Fehlmann D, Rummel G, Boivineau J, Duckely M, Gommermann N, Cotesta S, Sirockin F, Freuler F, Littlewood-Evans A, Kaupmann K, Jaakola VP | 10.1038/S41586-019-1663-8 | 2019-08-14 | Yes | |
| SUCR1 | succinate | Succinate | A | Rat | X-ray | 6RNK | 6RNK_refined | 1.9 | A | Active | 56 | 90 | - | - | - | - | - | Nanobody-6 |
NF-56-EJ40
|
small-molecule | Antagonist | - | - | No | No | Haffke M, Fehlmann D, Rummel G, Boivineau J, Duckely M, Gommermann N, Cotesta S, Sirockin F, Freuler F, Littlewood-Evans A, Kaupmann K, Jaakola VP | 10.1038/S41586-019-1663-8 | 2019-08-14 | Yes | |
| OPSD | Rhodopsin | Opsins | A | Bovine | Cryo-EM | 6OY9 | - | 3.9 | R | Active | 100 | 94 | Gi/o | αt1 | - | 64 | - | - |
Retinal (all-trans)
|
small-molecule | Agonist | - | - | No | No | Gao Y, Hu H, Ramachandran S, Erickson JW, Cerione RA, Skiniotis G | 10.1016/J.MOLCEL.2019.06.007 | 2019-07-24 | Yes | |
| OPSD | Rhodopsin | Opsins | A | Bovine | Cryo-EM | 6OYA | - | 3.3 | R | Active | 100 | 94 | Gi/o | αt1 | - | 59 | - | Camelid antibody VHH fragment |
Retinal (all-trans)
|
small-molecule | Agonist | - | - | No | No | Gao Y, Hu H, Ramachandran S, Erickson JW, Cerione RA, Skiniotis G | 10.1016/J.MOLCEL.2019.06.007 | 2019-07-24 | Yes | |
| EDNRB | ETB | Endothelin | A | Human | X-ray | 6K1Q | 6K1Q_refined | 2.7 | A | Inactive | 3 | 68 | - | - | - | - | T4-Lysozyme | - |
IRL 2500
|
peptide | Inverse agonist | endothelin-2, endothelin-3, endothelin-1 | peptide | No | No | Nagiri C, Shihoya W, Inoue A, Kadji FMN, Aoki J, Nureki O | 10.1038/S42003-019-0482-7 | 2019-07-17 | Yes | |
| NTR1 | NTS1 | Neurotensin | A | Human | Cryo-EM | 6OS9 | 6OS9_refined | 3.0 | R | Active | 100 | 73 | Gi/o | αi1 | - | 62 | - | scFv16 |
JMV449
|
peptide | Agonist | large neurotensin, neurotensin, neuromedin N, large neuromedin N | peptide | No | No | Kato HE, Zhang Y, Hu H, Suomivuori CM, Kadji FMN, Aoki J, Krishna Kumar K, Fonseca R, Hilger D, Huang W, Latorraca NR, Inoue A, Dror RO, Kobilka BK, Skiniotis G | 10.1038/S41586-019-1337-6 | 2019-07-10 | Yes | |
| NTR1 | NTS1 | Neurotensin | A | Human | Cryo-EM | 6OSA | - | 3.0 | R | Active | 100 | 77 | Gi/o | αi1 | Non-canonical conformation | 62 | - | - |
JMV449
|
peptide | Agonist | large neurotensin, neurotensin, neuromedin N, large neuromedin N | peptide | No | No | Kato HE, Zhang Y, Hu H, Suomivuori CM, Kadji FMN, Aoki J, Krishna Kumar K, Fonseca R, Hilger D, Huang W, Latorraca NR, Inoue A, Dror RO, Kobilka BK, Skiniotis G | 10.1038/S41586-019-1337-6 | 2019-07-10 | Yes | |
| OPSD | Rhodopsin | Opsins | A | Bovine | Cryo-EM | 6QNO | - | 4.4 | R | Active | 100 | 96 | Gi/o | αi1 | - | 60 | - | Fab antibody fragment light chain Fab antibody fragment heavy chain |
Retinal (all-trans)
|
small-molecule | Agonist | - | - | No | No | Tsai CJ, Marino J, Adaixo R, Pamula F, Muehle J, Maeda S, Flock T, Taylor NM, Mohammed I, Matile H, Dawson RJ, Deupi X, Stahlberg H, Schertler G | 10.7554/ELIFE.46041 | 2019-07-10 | Yes | |
| B1B1U5 | Rhodopsin | Opsins | A | Hasarius adansoni | X-ray | 6I9K | - | 2.2 | A | Inactive | 9 | 83 | - | - | - | - | - | - |
Retinal (11-cis)
|
small-molecule | Inverse agonist | - | - | No | No | Varma N, Mutt E, Muhle J, Panneels V, Terakita A, Deupi X, Nogly P, Schertler GFX, Lesca E | 10.1073/PNAS.1902192116 | 2019-07-03 | Yes | |
| SMO | SMO | Frizzled | F | Mouse | X-ray | 6O3C | 6O3C_refined | 2.8 | A | Active | 73 | 61 | - | - | - | - | - | Nanobody-Smo8 |
SAG21k
|
small-molecule | Agonist | - | - | No | No | Deshpande I, Liang J, Hedeen D, Roberts KJ, Zhang Y, Ha B, Latorraca NR, Faust B, Dror RO, Beachy PA, Myers BR, Manglik A | 10.1038/S41586-019-1355-4 | 2019-07-03 | Yes | |
| AA2AR | A2A | Adenosine | A | Human | X-ray | 6GT3 | 6GT3_refined | 2.0 | A | Inactive | 1 | 72 | - | - | - | - | BRIL | - |
imaradenant
|
small-molecule | Antagonist | adenosine | small-molecule | No | No | - | - | 2019-06-26 | Yes | |
| ADRB2 | β2 | Adrenoceptors | A | Human | X-ray | 6N48 | 6N48_refined | 3.2 | A | Active | 99 | 70 | - | - | - | - | T4-Lysozyme | Camelid Antibody Fragment |
CHEMBL1615159
2-[[(3R)-4-(4-Tert-butylphenyl)-3-[[2-(4-methoxyphenyl)sulfanyl-5-[methyl(propan-2-yl)sulfamoyl]benzoyl]amino]butanoyl]amino]acetic acid |
small-molecule small-molecule |
Agonist PAM |
Zn2+, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline | small-molecule | No | No | Liu X, Masoudi A, Kahsai AW, Huang LY, Pani B, Staus DP, Shim PJ, Hirata K, Simhal RK, Schwalb AM, Rambarat PK, Ahn S, Lefkowitz RJ, Kobilka B | 10.1126/SCIENCE.AAW8981 | 2019-06-26 | Yes | |
| SMO | SMO | Frizzled | F | Human | Cryo-EM | 6OT0 | - | 3.9 | R | Active | 100 | 46 | Gi/o | αi1 | - | 100 | - | Fab light chain Fab heavy chain |
24,25-Epoxy-cholesterol
|
small-molecule | Agonist | - | - | No | No | Qi X, Liu H, Thompson B, McDonald J, Zhang C, Li X | 10.1038/S41586-019-1286-0 | 2019-06-12 | Yes | |
| ADRB2 | β2 | Adrenoceptors | A | Human | X-ray | 6E67 | 6E67_refined | 3.7 | B | Active | 100 | 72 | Gs | αs | Fused partial Gs | 44 | T4-Lysozyme | - |
CHEMBL1615159
|
small-molecule | Agonist | Zn2+, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline | small-molecule | No | No | Liu X, Xu X, Hilger D, Aschauer P, Tiemann JKS, Du Y, Liu H, Hirata K, Sun X, Guixa-Gonzalez R, Mathiesen JM, Hildebrand PW, Kobilka BK | 10.1016/J.CELL.2019.04.021 | 2019-06-05 | Yes | |
| ACM1 | M1 | Acetylcholine (muscarinic) | A | Human | Cryo-EM | 6OIJ | 6OIJ_refined | 3.3 | R | Active | 100 | 64 | Gq/11 | α11 | - | 63 | - | Antibody fragment |
iperoxo
|
small-molecule | Agonist | acetylcholine | small-molecule | No | No | Maeda S, Qu Q, Robertson MJ, Skiniotis G, Kobilka BK | 10.1126/SCIENCE.AAW5188 | 2019-05-08 | Yes | |
| ACM2 | M2 | Acetylcholine (muscarinic) | A | Human | Cryo-EM | 6OIK | 6OIK_refined | 3.6 | R | Active | 100 | 60 | Gi/o | αo | - | 61 | - | - |
LY2119620
iperoxo |
small-molecule small-molecule |
Ago-PAM Agonist |
acetylcholine | small-molecule | No | No | Maeda S, Qu Q, Robertson MJ, Skiniotis G, Kobilka BK | 10.1126/SCIENCE.AAW5188 | 2019-05-08 | Yes | |
| AA2AR | A2A | Adenosine | A | Human | X-ray | 6MH8 | 6MH8_refined | 4.2 | A | Inactive | 1 | 72 | - | - | - | - | BRIL | - |
ZM-241385
|
small-molecule | Antagonist | adenosine | small-molecule | No | No | Martin-Garcia JM, Zhu L, Mendez D, Lee MY, Chun E, Li C, Hu H, Subramanian G, Kissick D, Ogata C, Henning R, Ishchenko A, Dobson Z, Zhang S, Weierstall U, Spence JCH, Fromme P, Zatsepin NA, Fischetti RF, Cherezov V, Liu W | 10.1107/S205225251900263X | 2019-04-24 | Yes | |
| MTR1A | MT1 | Melatonin | A | Human | X-ray | 6ME5 | 6ME5_refined | 3.2 | A | Inactive | 1 | 83 | - | - | - | - | GlgA glycogen synthase | - |
agomelatine
|
small-molecule | Agonist | melatonin | small-molecule | No | No | Stauch B, Johansson LC, McCorvy JD, Patel N, Han GW, Huang XP, Gati C, Batyuk A, Slocum ST, Ishchenko A, Brehm W, White TA, Michaelian N, Madsen C, Zhu L, Grant TD, Grandner JM, Shiriaeva A, Olsen RHJ, Tribo AR, Yous S, Stevens RC, Weierstall U, Katritch V, Roth BL, Liu W, Cherezov V | 10.1038/S41586-019-1141-3 | 2019-04-24 | Yes | |
| MTR1A | MT1 | Melatonin | A | Human | X-ray | 6ME2 | 6ME2_refined | 2.8 | A | Inactive | 1 | 83 | - | - | - | - | GlgA glycogen synthase | - |
ramelteon
|
small-molecule | Agonist | melatonin | small-molecule | No | No | Stauch B, Johansson LC, McCorvy JD, Patel N, Han GW, Huang XP, Gati C, Batyuk A, Slocum ST, Ishchenko A, Brehm W, White TA, Michaelian N, Madsen C, Zhu L, Grant TD, Grandner JM, Shiriaeva A, Olsen RHJ, Tribo AR, Yous S, Stevens RC, Weierstall U, Katritch V, Roth BL, Liu W, Cherezov V | 10.1038/S41586-019-1141-3 | 2019-04-24 | Yes | |
| MTR1A | MT1 | Melatonin | A | Human | X-ray | 6ME3 | 6ME3_refined | 2.9 | A | Inactive | 1 | 82 | - | - | - | - | GlgA glycogen synthase | - |
CHEMBL15060
|
small-molecule | Agonist | melatonin | small-molecule | No | No | Stauch B, Johansson LC, McCorvy JD, Patel N, Han GW, Huang XP, Gati C, Batyuk A, Slocum ST, Ishchenko A, Brehm W, White TA, Michaelian N, Madsen C, Zhu L, Grant TD, Grandner JM, Shiriaeva A, Olsen RHJ, Tribo AR, Yous S, Stevens RC, Weierstall U, Katritch V, Roth BL, Liu W, Cherezov V | 10.1038/S41586-019-1141-3 | 2019-04-24 | Yes | |
| MTR1A | MT1 | Melatonin | A | Human | X-ray | 6ME4 | 6ME4_refined | 3.2 | A | Inactive | 1 | 83 | - | - | - | - | GlgA glycogen synthase | - |
2-iodo-melatonin
|
small-molecule | Agonist | melatonin | small-molecule | No | No | Stauch B, Johansson LC, McCorvy JD, Patel N, Han GW, Huang XP, Gati C, Batyuk A, Slocum ST, Ishchenko A, Brehm W, White TA, Michaelian N, Madsen C, Zhu L, Grant TD, Grandner JM, Shiriaeva A, Olsen RHJ, Tribo AR, Yous S, Stevens RC, Weierstall U, Katritch V, Roth BL, Liu W, Cherezov V | 10.1038/S41586-019-1141-3 | 2019-04-24 | Yes | |
| MTR1B | MT2 | Melatonin | A | Human | X-ray | 6ME9 | 6ME9_refined | 3.3 | B | Inactive | 1 | 79 | - | - | - | - | Rubredoxin | - |
ramelteon
|
small-molecule | Agonist | melatonin | small-molecule | No | No | Johansson LC, Stauch B, McCorvy JD, Han GW, Patel N, Huang XP, Batyuk A, Gati C, Slocum ST, Li C, Grandner JM, Hao S, Olsen RHJ, Tribo AR, Zaare S, Zhu L, Zatsepin NA, Weierstall U, Yous S, Stevens RC, Liu W, Roth BL, Katritch V, Cherezov V | 10.1038/S41586-019-1144-0 | 2019-04-24 | Yes | |
| MTR1B | MT2 | Melatonin | A | Human | X-ray | 6ME8 | 6ME8_refined | 3.1 | B | Inactive | 1 | 78 | - | - | - | - | Rubredoxin | - |
CHEMBL15060
|
small-molecule | Agonist | melatonin | small-molecule | No | No | Johansson LC, Stauch B, McCorvy JD, Han GW, Patel N, Huang XP, Batyuk A, Gati C, Slocum ST, Li C, Grandner JM, Hao S, Olsen RHJ, Tribo AR, Zaare S, Zhu L, Zatsepin NA, Weierstall U, Yous S, Stevens RC, Liu W, Roth BL, Katritch V, Cherezov V | 10.1038/S41586-019-1144-0 | 2019-04-24 | Yes | |
| MTR1B | MT2 | Melatonin | A | Human | X-ray | 6ME7 | 6ME7_refined | 3.2 | A | Inactive | 1 | 79 | - | - | - | - | Rubredoxin | - |
CHEMBL15060
|
small-molecule | Agonist | melatonin | small-molecule | No | No | - | - | 2019-04-24 | Yes | |
| MTR1B | MT2 | Melatonin | A | Human | X-ray | 6ME6 | 6ME6_refined | 2.8 | B | Inactive | 1 | 78 | - | - | - | - | Rubredoxin | - |
CHEMBL15060
|
small-molecule | Agonist | melatonin | small-molecule | No | No | Johansson LC, Stauch B, McCorvy JD, Han GW, Patel N, Huang XP, Batyuk A, Gati C, Slocum ST, Li C, Grandner JM, Hao S, Olsen RHJ, Tribo AR, Zaare S, Zhu L, Zatsepin NA, Weierstall U, Yous S, Stevens RC, Liu W, Roth BL, Katritch V, Cherezov V | 10.1038/S41586-019-1144-0 | 2019-04-24 | Yes | |
| PTH1R | PTH1 | Parathyroid hormone | B1 | Human | Cryo-EM | 6NBH | - | 3.5 | R | Active | 100 | 64 | Gs | αs | - | 57 | - | Nanobody-35 |
Long-acting parathyroid hormone analog
|
peptide | Agonist | PTH, PTHrP, TIP39, PTHrP-(1-36) | peptide | No | No | Zhao LH, Ma S, Sutkeviciute I, Shen DD, Zhou XE, de Waal PW, Li CY, Kang Y, Clark LJ, Jean-Alphonse FG, White AD, Yang D, Dai A, Cai X, Chen J, Li C, Jiang Y, Watanabe T, Gardella TJ, Melcher K, Wang MW, Vilardaga JP, Xu HE, Zhang Y | 10.1126/SCIENCE.AAV7942 | 2019-04-17 | Yes | |
| PTH1R | PTH1 | Parathyroid hormone | B1 | Human | Cryo-EM | 6NBF | - | 3.0 | R | Active | 100 | 62 | Gs | αs | - | 58 | - | Nanobody-35 |
Long-acting parathyroid hormone analog
|
peptide | Agonist | PTH, PTHrP, TIP39, PTHrP-(1-36) | peptide | No | No | Zhao LH, Ma S, Sutkeviciute I, Shen DD, Zhou XE, de Waal PW, Li CY, Kang Y, Clark LJ, Jean-Alphonse FG, White AD, Yang D, Dai A, Cai X, Chen J, Li C, Jiang Y, Watanabe T, Gardella TJ, Melcher K, Wang MW, Vilardaga JP, Xu HE, Zhang Y | 10.1126/SCIENCE.AAV7942 | 2019-04-17 | Yes | |
| PTH1R | PTH1 | Parathyroid hormone | B1 | Human | Cryo-EM | 6NBI | - | 4.0 | R | Active | 100 | 62 | Gs | αs | - | 56 | - | Nanobody-35 |
Long-acting parathyroid hormone analog
|
peptide | Agonist | PTH, PTHrP, TIP39, PTHrP-(1-36) | peptide | No | No | Zhao LH, Ma S, Sutkeviciute I, Shen DD, Zhou XE, de Waal PW, Li CY, Kang Y, Clark LJ, Jean-Alphonse FG, White AD, Yang D, Dai A, Cai X, Chen J, Li C, Jiang Y, Watanabe T, Gardella TJ, Melcher K, Wang MW, Vilardaga JP, Xu HE, Zhang Y | 10.1126/SCIENCE.AAV7942 | 2019-04-17 | Yes | |
| NK1R | NK1 | Tachykinin | A | Human | X-ray | 6J21 | 6J21_refined | 3.2 | A | Inactive | 1 | 71 | - | - | - | - | T4-Lysozyme | - |
aprepitant
|
small-molecule | Antagonist | neurokinin A, neuropeptide K, hemokinin 1, neurokinin B, neuropeptide-γ, substance P | peptide | No | No | Chen S, Lu M, Liu D, Yang L, Yi C, Ma L, Zhang H, Liu Q, Frimurer TM, Wang MW, Schwartz TW, Stevens RC, Wu B, Wuthrich K, Zhao Q | 10.1038/S41467-019-08568-5 | 2019-03-06 | Yes | |
| NK1R | NK1 | Tachykinin | A | Human | X-ray | 6J20 | 6J20_refined | 2.7 | A | Inactive | 1 | 71 | - | - | - | - | T4-Lysozyme | - |
aprepitant
|
small-molecule | Antagonist | neurokinin A, neuropeptide K, hemokinin 1, neurokinin B, neuropeptide-γ, substance P | peptide | No | No | Chen S, Lu M, Liu D, Yang L, Yi C, Ma L, Zhang H, Liu Q, Frimurer TM, Wang MW, Schwartz TW, Stevens RC, Wu B, Wuthrich K, Zhao Q | 10.1038/S41467-019-08568-5 | 2019-03-06 | Yes | |
| 5HT2A | 5-HT2A | 5-Hydroxytryptamine | A | Human | X-ray | 6A94 | 6A94_refined | 2.9 | A | Inactive | 1 | 60 | - | - | - | - | BRIL | - |
zotepine
|
small-molecule | Antagonist | tryptamine, 5-hydroxytryptamine | small-molecule | No | No | Kimura KT, Asada H, Inoue A, Kadji FMN, Im D, Mori C, Arakawa T, Hirata K, Nomura Y, Nomura N, Aoki J, Iwata S, Shimamura T | 10.1038/S41594-018-0180-Z | 2019-02-13 | Yes | |
| 5HT2A | 5-HT2A | 5-Hydroxytryptamine | A | Human | X-ray | 6A93 | 6A93_refined | 3.0 | A | Inactive | 1 | 60 | - | - | - | - | BRIL | - |
risperidone
|
small-molecule | Antagonist | tryptamine, 5-hydroxytryptamine | small-molecule | No | No | Kimura KT, Asada H, Inoue A, Kadji FMN, Im D, Mori C, Arakawa T, Hirata K, Nomura Y, Nomura N, Aoki J, Iwata S, Shimamura T | 10.1038/S41594-018-0180-Z | 2019-02-13 | Yes | |
| AGTR1 | AT1 | Angiotensin | A | Human | X-ray | 6DO1 | 6DO1_refined | 2.9 | A | Active | 93 | 85 | - | - | - | - | BRIL | Nanobody-Nb.AT110i1 |
CHEMBL404594
|
protein | Agonist | angiotensin III, angiotensin IV, angiotensin A, angiotensin II | peptide | No | No | Wingler LM, McMahon C, Staus DP, Lefkowitz RJ, Kruse AC | 10.1016/J.CELL.2018.12.006 | 2019-01-30 | Yes | |
| CNR1 | CB1 | Cannabinoid | A | Human | Cryo-EM | 6N4B | 6N4B_refined | 3.0 | R | Active | 100 | 58 | Gi/o | αi1 | - | 62 | - | scFv16 |
MDMB-Fubinaca
|
small-molecule | Agonist | 2-arachidonoylglycerol, anandamide | small-molecule | No | No | Krishna Kumar K, Shalev-Benami M, Robertson MJ, Hu H, Banister SD, Hollingsworth SA, Latorraca NR, Kato HE, Hilger D, Maeda S, Weis WI, Farrens DL, Dror RO, Malhotra SV, Kobilka BK, Skiniotis G | 10.1016/J.CELL.2018.11.040 | 2019-01-30 | Yes | |
| CNR2 | CB2 | Cannabinoid | A | Human | X-ray | 5ZTY | 5ZTY_refined | 2.8 | A | Inactive | 4 | 80 | - | - | - | - | T4-Lysozyme | - |
AM10257
|
small-molecule | Antagonist | 2-arachidonoylglycerol, anandamide | small-molecule | No | No | Li X, Hua T, Vemuri K, Ho JH, Wu Y, Wu L, Popov P, Benchama O, Zvonok N, Locke K, Qu L, Han GW, Iyer MR, Cinar R, Coffey NJ, Wang J, Wu M, Katritch V, Zhao S, Kunos G, Bohn LM, Makriyannis A, Stevens RC, Liu ZJ | 10.1016/J.CELL.2018.12.011 | 2019-01-30 | Yes | |
| CALCR | CT | Calcitonin | B1 | Human | Cryo-EM | 6NIY | - | 3.3 | R | Active | 100 | 55 | Gs | αs | - | 43 | - | - |
calcitonin (salmon synthetic)
|
small-molecule | Agonist | adrenomedullin, calcitonin, β-CGRP, adrenomedullin 2/intermedin, α-CGRP, amylin | peptide | No | No | Dal Maso E, Glukhova A, Zhu Y, Garcia-Nafria J, Tate CG, Atanasio S, Reynolds CA, Ramirez-Aportela E, Carazo JM, Hick CA, Furness SGB, Hay DL, Liang YL, Miller LJ, Christopoulos A, Wang MW, Wootten D, Sexton PM | 10.1021/ACSPTSCI.8B00056 | 2019-01-23 | Yes | |
| GRM5 | mGlu5 | Metabotropic glutamate | C | Human | Cryo-EM | 6N52 | 6N52_refined | 4.0 | A | Inactive | - | 64 | - | - | - | - | - | Nanobody-43 |
Apo (no ligand)
|
none | Apo (no ligand) | L-glutamic acid | small-molecule | No | No | Koehl A, Hu H, Feng D, Sun B, Zhang Y, Robertson MJ, Chu M, Kobilka TS, Laeremans T, Steyaert J, Tarrasch J, Dutta S, Fonseca R, Weis WI, Mathiesen JM, Skiniotis G, Kobilka BK | 10.1038/S41586-019-0881-4 | 2019-01-23 | Yes | |
| GRM5 | mGlu5 | Metabotropic glutamate | C | Human | Cryo-EM | 6N51 | 6N51_refined | 4.0 | B | Intermediate | - | 65 | - | - | - | - | - | Nanobody-43 |
quisqualate
|
small-molecule | Agonist | L-glutamic acid | small-molecule | No | No | Koehl A, Hu H, Feng D, Sun B, Zhang Y, Robertson MJ, Chu M, Kobilka TS, Laeremans T, Steyaert J, Tarrasch J, Dutta S, Fonseca R, Weis WI, Mathiesen JM, Skiniotis G, Kobilka BK | 10.1038/S41586-019-0881-4 | 2019-01-23 | Yes | |
| NK1R | NK1 | Tachykinin | A | Human | X-ray | 6HLO | 6HLO_refined | 2.4 | A | Inactive | 1 | 70 | - | - | - | - | GlgA glycogen synthase | - |
aprepitant
|
small-molecule | Antagonist | neurokinin A, neuropeptide K, hemokinin 1, neurokinin B, neuropeptide-γ, substance P | peptide | No | No | Schoppe J, Ehrenmann J, Klenk C, Rucktooa P, Schutz M, Dore AS, Pluckthun A | 10.1038/S41467-018-07939-8 | 2019-01-16 | Yes | |
| NK1R | NK1 | Tachykinin | A | Human | X-ray | 6HLL | 6HLL_refined | 3.3 | A | Inactive | 1 | 67 | - | - | - | - | GlgA glycogen synthase | - |
CP 99994
|
small-molecule | Antagonist | neurokinin A, neuropeptide K, hemokinin 1, neurokinin B, neuropeptide-γ, substance P | peptide | No | No | Schoppe J, Ehrenmann J, Klenk C, Rucktooa P, Schutz M, Dore AS, Pluckthun A | 10.1038/S41467-018-07939-8 | 2019-01-16 | Yes | |
| NK1R | NK1 | Tachykinin | A | Human | X-ray | 6HLP | 6HLP_refined | 2.2 | A | Inactive | 1 | 71 | - | - | - | - | GlgA glycogen synthase | - |
netupitant
|
small-molecule | Antagonist | neurokinin A, neuropeptide K, hemokinin 1, neurokinin B, neuropeptide-γ, substance P | peptide | No | No | Schoppe J, Ehrenmann J, Klenk C, Rucktooa P, Schutz M, Dore AS, Pluckthun A | 10.1038/S41467-018-07939-8 | 2019-01-16 | Yes | |
| ADRB1 | β1 | Adrenoceptors | A | Wild turkey | X-ray | 6IBL | 6IBL_refined | 2.7 | A | Active | 99 | 60 | - | - | - | - | Thioredoxin 1 | Camelid antibody fragment Nb80 |
ARFORMOTEROL
|
small-molecule | Agonist | - | - | No | No | Lee Y, Warne T, Nehme R, Pandey S, Dwivedi-Agnihotri H, Chaturvedi M, Edwards PC, Garcia-Nafria J, Leslie AGW, Shukla AK, Tate CG | 10.1038/S41586-020-2419-1 | 2019-01-09 | Yes | |
| CCR2 | CCR2 | Chemokine | A | Human | X-ray | 6GPS | 6GPS_refined | 3.3 | A | Inactive | 9 | 74 | - | - | - | - | Rubredoxin | - |
MK-0812
|
small-molecule | Antagonist | CCL13, CCL11, CCL26, CCL8, CCL2, CCL7, CCL24, CCL16 | peptide | No | No | Apel AK, Cheng RKY, Tautermann CS, Brauchle M, Huang CY, Pautsch A, Hennig M, Nar H, Schnapp G | 10.1016/J.STR.2018.10.027 | 2019-01-02 | Yes | |
| CCR2 | CCR2 | Chemokine | A | Human | X-ray | 6GPX | 6GPX_refined | 2.7 | B | Inactive | 9 | 70 | - | - | - | - | Rubredoxin | - |
MK-0812
|
small-molecule | Antagonist | CCL13, CCL11, CCL26, CCL8, CCL2, CCL7, CCL24, CCL16 | peptide | No | No | Apel AK, Cheng RKY, Tautermann CS, Brauchle M, Huang CY, Pautsch A, Hennig M, Nar H, Schnapp G | 10.1016/J.STR.2018.10.027 | 2019-01-02 | Yes | |
| TA2R | TP | Prostanoid | A | Human | X-ray | 6IIV | 6IIV_refined | 3.0 | A | Inactive | 33 | 87 | - | - | - | - | Rubredoxin | - |
daltroban
|
small-molecule | Antagonist | PGF2α, PGH2, PGI2, PGE2, thromboxane A2, PGD2 | small-molecule | No | No | Fan H, Chen S, Yuan X, Han S, Zhang H, Xia W, Xu Y, Zhao Q, Wu B | 10.1038/S41589-018-0170-9 | 2018-12-19 | Yes | |
| TA2R | TP | Prostanoid | A | Human | X-ray | 6IIU | 6IIU_refined | 2.5 | A | Inactive | 33 | 87 | - | - | - | - | Rubredoxin | - |
ramatroban
|
small-molecule | Antagonist | PGF2α, PGH2, PGI2, PGE2, thromboxane A2, PGD2 | small-molecule | No | No | Fan H, Chen S, Yuan X, Han S, Zhang H, Xia W, Xu Y, Zhao Q, Wu B | 10.1038/S41589-018-0170-9 | 2018-12-19 | Yes | |
| CCR5 | CCR5 | Chemokine | A | Human | Cryo-EM | 6MEO | 6MEO_refined | 3.9 | B | Inactive | 9 | 89 | - | - | - | - | - | T-cell surface glycoprotein CD4 |
Envelope glycoprotein gp160
|
protein | Antagonist | CCL13, CCL11, CCL8, CCL2, CCL7, CCL4, CCL5, CCL14, CCL3, CCL16 | peptide | No | No | Shaik MM, Peng H, Lu J, Rits-Volloch S, Xu C, Liao M, Chen B | 10.1038/S41586-018-0804-9 | 2018-12-12 | Yes | |
| CCR5 | CCR5 | Chemokine | A | Human | Cryo-EM | 6MET | 6MET_refined | 4.5 | B | Inactive | 9 | 89 | - | - | - | - | - | T-cell surface glycoprotein CD4 |
Envelope glycoprotein gp160
|
protein | Antagonist | CCL13, CCL11, CCL8, CCL2, CCL7, CCL4, CCL5, CCL14, CCL3, CCL16 | peptide | No | No | Shaik MM, Peng H, Lu J, Rits-Volloch S, Xu C, Liao M, Chen B | 10.1038/S41586-018-0804-9 | 2018-12-12 | Yes | |
| NK1R | NK1 | Tachykinin | A | Human | X-ray | 6E59 | 6E59_refined | 3.4 | A | Inactive | 1 | 70 | - | - | - | - | GlgA glycogen synthase | - |
L760735
|
small-molecule | Antagonist | neurokinin A, neuropeptide K, hemokinin 1, neurokinin B, neuropeptide-γ, substance P | peptide | No | No | Yin J, Chapman K, Clark LD, Shao Z, Borek D, Xu Q, Wang J, Rosenbaum DM | 10.1073/PNAS.1812717115 | 2018-12-12 | Yes | |
| PE2R3 | EP3 | Prostanoid | A | Human | X-ray | 6AK3 | 6AK3_refined | 2.9 | B | Active | 88 | 69 | - | - | - | - | BRIL | - |
PGE2
|
small-molecule | Agonist | PGE1, PGF2α, PGI2, PGE2, thromboxane A2, PGD2 | small-molecule | No | No | Morimoto K, Suno R, Hotta Y, Yamashita K, Hirata K, Yamamoto M, Narumiya S, Iwata S, Kobayashi T | 10.1038/S41589-018-0171-8 | 2018-12-05 | Yes | |
| PE2R3 | EP3 | Prostanoid | A | Human | X-ray | 6M9T | 6M9T_refined | 2.5 | A | Active | 88 | 70 | - | - | - | - | T4-Lysozyme | - |
Misoprostol-FA
|
small-molecule | Agonist | PGE1, PGF2α, PGI2, PGE2, thromboxane A2, PGD2 | small-molecule | No | No | Audet M, White KL, Breton B, Zarzycka B, Han GW, Lu Y, Gati C, Batyuk A, Popov P, Velasquez J, Manahan D, Hu H, Weierstall U, Liu W, Shui W, Katritch V, Cherezov V, Hanson MA, Stevens RC | 10.1038/S41589-018-0160-Y | 2018-12-05 | Yes | |
| PE2R4 | EP4 | Prostanoid | A | Human | X-ray | 5YHL | 5YHL_refined | 4.2 | A | Inactive | 12 | 57 | - | - | - | - | - | Fab |
ONO-AE3-208-Br
|
small-molecule | Antagonist | PGE1, PGF2α, PGI2, PGE2, thromboxane A2, PGD2 | small-molecule | No | No | Toyoda Y, Morimoto K, Suno R, Horita S, Yamashita K, Hirata K, Sekiguchi Y, Yasuda S, Shiroishi M, Shimizu T, Urushibata Y, Kajiwara Y, Inazumi T, Hotta Y, Asada H, Nakane T, Shiimura Y, Nakagita T, Tsuge K, Yoshida S, Kuribara T, Hosoya T, Sugimoto Y, Nomura N, Sato M, Hirokawa T, Kinoshita M, Murata T, Takayama K, Yamamoto M, Narumiya S, Iwata S, Kobayashi T | 10.1038/S41589-018-0131-3 | 2018-12-05 | Yes | |
| PE2R4 | EP4 | Prostanoid | A | Human | X-ray | 5YWY | 5YWY_refined | 3.2 | A | Inactive | 12 | 57 | - | - | - | - | - | Fab |
ONO-AE3-208
|
small-molecule | Antagonist | PGE1, PGF2α, PGI2, PGE2, thromboxane A2, PGD2 | small-molecule | No | No | Toyoda Y, Morimoto K, Suno R, Horita S, Yamashita K, Hirata K, Sekiguchi Y, Yasuda S, Shiroishi M, Shimizu T, Urushibata Y, Kajiwara Y, Inazumi T, Hotta Y, Asada H, Nakane T, Shiimura Y, Nakagita T, Tsuge K, Yoshida S, Kuribara T, Hosoya T, Sugimoto Y, Nomura N, Sato M, Hirokawa T, Kinoshita M, Murata T, Takayama K, Yamamoto M, Narumiya S, Iwata S, Kobayashi T | 10.1038/S41589-018-0131-3 | 2018-12-05 | Yes | |
| ACM3 | M3 | Acetylcholine (muscarinic) | A | Rat | X-ray | 5ZHP | 5ZHP_refined | 3.1 | B | Inactive | 3 | 47 | - | - | - | - | T4-Lysozyme | - |
(1R,2R,4S,5S,7s)-7-({[4-fluoro-2-(thiophen-2-yl)phenyl]carbamoyl}oxy)-9,9-dimethyl-3-oxa-9-azatricyclo[3.3.1.0~2,4~]nonan-9-ium
|
small-molecule | Antagonist | acetylcholine | small-molecule | No | No | Liu H, Hofmann J, Fish I, Schaake B, Eitel K, Bartuschat A, Kaindl J, Rampp H, Banerjee A, Hubner H, Clark MJ, Vincent SG, Fisher JT, Heinrich MR, Hirata K, Liu X, Sunahara RK, Shoichet BK, Kobilka BK, Gmeiner P | 10.1073/PNAS.1813988115 | 2018-11-28 | Yes | |
| ACM2 | M2 | Acetylcholine (muscarinic) | A | Human | X-ray | 5ZK3 | 5ZK3_refined | 2.6 | A | Inactive | 3 | 59 | - | - | - | - | BRIL | - |
CHEMBL558910
|
small-molecule | Antagonist | acetylcholine | small-molecule | No | No | Suno R, Lee S, Maeda S, Yasuda S, Yamashita K, Hirata K, Horita S, Tawaramoto MS, Tsujimoto H, Murata T, Kinoshita M, Yamamoto M, Kobilka BK, Vaidehi N, Iwata S, Kobayashi T | 10.1038/S41589-018-0152-Y | 2018-11-21 | Yes | |
| ACM2 | M2 | Acetylcholine (muscarinic) | A | Human | X-ray | 5ZKC | 5ZKC_refined | 2.3 | A | Inactive | 3 | 60 | - | - | - | - | BRIL | - |
N-methyl scopolamine
|
small-molecule | Antagonist | acetylcholine | small-molecule | No | No | Suno R, Lee S, Maeda S, Yasuda S, Yamashita K, Hirata K, Horita S, Tawaramoto MS, Tsujimoto H, Murata T, Kinoshita M, Yamamoto M, Kobilka BK, Vaidehi N, Iwata S, Kobayashi T | 10.1038/S41589-018-0152-Y | 2018-11-21 | Yes | |
| ACM2 | M2 | Acetylcholine (muscarinic) | A | Human | X-ray | 5ZKB | 5ZKB_refined | 3.0 | A | Inactive | 3 | 60 | - | - | - | - | BRIL | - |
AF-DX 384
|
small-molecule | Antagonist | acetylcholine | small-molecule | No | No | Suno R, Lee S, Maeda S, Yasuda S, Yamashita K, Hirata K, Horita S, Tawaramoto MS, Tsujimoto H, Murata T, Kinoshita M, Yamamoto M, Kobilka BK, Vaidehi N, Iwata S, Kobayashi T | 10.1038/S41589-018-0152-Y | 2018-11-21 | Yes | |
| ACM2 | M2 | Acetylcholine (muscarinic) | A | Human | X-ray | 5ZK8 | 5ZK8_refined | 3.0 | A | Inactive | 3 | 59 | - | - | - | - | BRIL | - |
N-methyl scopolamine
|
small-molecule | Antagonist | acetylcholine | small-molecule | No | No | Suno R, Lee S, Maeda S, Yasuda S, Yamashita K, Hirata K, Horita S, Tawaramoto MS, Tsujimoto H, Murata T, Kinoshita M, Yamamoto M, Kobilka BK, Vaidehi N, Iwata S, Kobayashi T | 10.1038/S41589-018-0152-Y | 2018-11-21 | Yes | |
| ACM2 | M2 | Acetylcholine (muscarinic) | A | Human | X-ray | 5YC8 | 5YC8_refined | 2.5 | A | Inactive | 3 | 60 | - | - | - | - | BRIL | - |
N-methyl scopolamine
|
small-molecule | Antagonist | acetylcholine | small-molecule | No | No | Suno R, Lee S, Maeda S, Yasuda S, Yamashita K, Hirata K, Horita S, Tawaramoto MS, Tsujimoto H, Murata T, Kinoshita M, Yamamoto M, Kobilka BK, Vaidehi N, Iwata S, Kobayashi T | 10.1038/S41589-018-0152-Y | 2018-11-21 | Yes | |
| EDNRB | ETB | Endothelin | A | Human | X-ray | 6IGK | 6IGK_refined | 2.0 | A | Inactive | 3 | 70 | - | - | - | - | T4-Lysozyme | - |
endothelin-3
|
peptide | Agonist | endothelin-2, endothelin-3, endothelin-1 | peptide | No | No | Shihoya W, Izume T, Inoue A, Yamashita K, Kadji FMN, Hirata K, Aoki J, Nishizawa T, Nureki O | 10.1038/S41467-018-07094-0 | 2018-11-21 | Yes | |
| EDNRB | ETB | Endothelin | A | Human | X-ray | 6IGL | - | 2.7 | A | Inactive | 3 | 70 | - | - | - | - | T4-Lysozyme | - |
sovateltide
|
peptide | Agonist (partial) | endothelin-2, endothelin-3, endothelin-1 | peptide | No | No | Shihoya W, Izume T, Inoue A, Yamashita K, Kadji FMN, Hirata K, Aoki J, Nishizawa T, Nureki O | 10.1038/S41467-018-07094-0 | 2018-11-21 | Yes | |
| PTH1R | PTH1 | Parathyroid hormone | B1 | Human | X-ray | 6FJ3 | - | 2.5 | A | Inactive | 0 | 62 | - | - | - | - | GlgA glycogen synthase | - |
ePTH
|
peptide | Agonist (partial) | PTH, PTHrP, TIP39, PTHrP-(1-36) | peptide | No | No | Ehrenmann J, Schoppe J, Klenk C, Rappas M, Kummer L, Dore AS, Pluckthun A | 10.1038/S41594-018-0151-4 | 2018-11-21 | Yes | |
| ADRB2 | β2 | Adrenoceptors | A | Human | X-ray | 6MXT | 6MXT_refined | 3.0 | A | Active | 99 | 69 | - | - | - | - | T4-Lysozyme | Nanobody-71 |
salmeterol
|
small-molecule | Agonist | Zn2+, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline | small-molecule | No | No | Masureel M, Zou Y, Picard LP, van der Westhuizen E, Mahoney JP, Rodrigues JPGLM, Mildorf TJ, Dror RO, Shaw DE, Bouvier M, Pardon E, Steyaert J, Sunahara RK, Weis WI, Zhang C, Kobilka BK | 10.1038/s41589-018-0145-x | 2018-11-14 | Yes | |
| CCR5 | CCR5 | Chemokine | A | Human | X-ray | 6AKY | 6AKY_refined | 2.8 | A | Inactive | 9 | 81 | - | - | - | - | Rubredoxin | - |
CCR5 antagonist 34
|
small-molecule | Antagonist | CCL13, CCL11, CCL8, CCL2, CCL7, CCL4, CCL5, CCL14, CCL3, CCL16 | peptide | No | No | Peng P, Chen H, Zhu Y, Wang Z, Li J, Luo RH, Wang J, Chen L, Yang LM, Jiang H, Xie X, Wu B, Zheng YT, Liu H. | 10.1021/acs.jmedchem.8b01077 | 2018-10-24 | Yes | |
| CCR5 | CCR5 | Chemokine | A | Human | X-ray | 6AKX | 6AKX_refined | 2.8 | B | Inactive | 9 | 82 | - | - | - | - | Rubredoxin | - |
CHEMBL4238063
|
small-molecule | Antagonist | CCL13, CCL11, CCL8, CCL2, CCL7, CCL4, CCL5, CCL14, CCL3, CCL16 | peptide | No | No | Peng P, Chen H, Zhu Y, Wang Z, Li J, Luo RH, Wang J, Chen L, Yang LM, Jiang H, Xie X, Wu B, Zheng YT, Liu H. | 10.1021/acs.jmedchem.8b01077 | 2018-10-24 | Yes | |
| ADRB1 | β1 | Adrenoceptors | A | Wild turkey | X-ray | 6H7N | 6H7N_refined | 2.5 | A | Active | 99 | 60 | - | - | - | - | Thioredoxin 1 | Camelid antibody fragment Nb6B9 |
(S)-Xamoterol
|
small-molecule | Agonist | - | - | No | No | Hu S, Oppong A, Mogo E, Collins C, Occhini G, Barford A, Korhonen A | 10.1101/436212 | 2018-10-17 | Yes | |
| ADRB1 | β1 | Adrenoceptors | A | Wild turkey | X-ray | 6H7L | 6H7L_refined | 2.7 | A | Active | 99 | 60 | - | - | - | - | Thioredoxin 1 | Camelid antibody fragment Nb6B9 |
Dobutamine
|
small-molecule | Agonist | - | - | No | No | Warne T, Edwards PC, Dore AS, Leslie AGW, Tate CG | 10.1126/SCIENCE.AAU5595 | 2018-10-17 | Yes | |
| ADRB1 | β1 | Adrenoceptors | A | Wild turkey | X-ray | 6H7O | 6H7O_refined | 2.8 | A | Active | 99 | 60 | - | - | - | - | Thioredoxin 1 | Camelid antibody fragment Nb6B9 |
(S)-Cyanopindolol
|
small-molecule | Agonist | - | - | No | No | Warne T, Edwards PC, Dore AS, Leslie AGW, Tate CG | 10.1126/SCIENCE.AAU5595 | 2018-10-17 | Yes | |
| ADRB1 | β1 | Adrenoceptors | A | Wild turkey | X-ray | 6H7M | 6H7M_refined | 2.8 | A | Active | 99 | 60 | - | - | - | - | Thioredoxin 1 | Camelid antibody fragment Nb6B9 |
levosalbutamol
|
small-molecule | Agonist | - | - | No | No | Warne T, Edwards PC, Dore AS, Leslie AGW, Tate CG | 10.1126/SCIENCE.AAU5595 | 2018-10-17 | Yes | |
| ADRB1 | β1 | Adrenoceptors | A | Wild turkey | X-ray | 6H7J | 6H7J_refined | 2.8 | A | Active | 99 | 60 | - | - | - | - | Thioredoxin 1 | Camelid antibody fragment Nb80 |
LEVISOPRENALINE
|
small-molecule | Agonist | - | - | No | No | Warne T, Edwards PC, Dore AS, Leslie AGW, Tate CG | 10.1126/SCIENCE.AAU5595 | 2018-10-17 | Yes | |
| OPSD | Rhodopsin | Opsins | A | Bovine | X-ray | 6FUF | 6FUF_refined | 3.1 | A | Active | 100 | 91 | Gi/o | αo | Mini-Go | 51 | - | - |
Retinal (all-trans)
|
small-molecule | Agonist | - | - | No | No | Tsai CJ, Pamula F, Nehme R, Muhle J, Weinert T, Flock T, Nogly P, Edwards PC, Carpenter B, Gruhl T, Ma P, Deupi X, Standfuss J, Tate CG, Schertler GFX | 10.1126/SCIADV.AAT7052 | 2018-10-03 | Yes | |
| PD2R2 | DP2 | Prostanoid | A | Human | X-ray | 6D27 | 6D27_refined | 2.7 | A | Inactive | 21 | 81 | - | - | - | - | T4-Lysozyme | - |
CHEMBL179036
|
small-molecule | Antagonist | PGD3, PGF2α, PGI2, PGJ2, PGE2, thromboxane A2, PGD2 | small-molecule | No | No | Wang L, Yao D, Deepak RNVK, Liu H, Xiao Q, Fan H, Gong W, Wei Z, Zhang C | 10.1016/J.MOLCEL.2018.08.009 | 2018-10-03 | Yes | |
| PD2R2 | DP2 | Prostanoid | A | Human | X-ray | 6D26 | 6D26_refined | 2.8 | A | Inactive | 21 | 82 | - | - | - | - | T4-Lysozyme | - |
fevipiprant
|
small-molecule | Antagonist | PGD3, PGF2α, PGI2, PGJ2, PGE2, thromboxane A2, PGD2 | small-molecule | No | No | Wang L, Yao D, Deepak RNVK, Liu H, Xiao Q, Fan H, Gong W, Wei Z, Zhang C | 10.1016/J.MOLCEL.2018.08.009 | 2018-10-03 | Yes | |
| CALRL | calcitonin-like | Calcitonin | B1 | Human | Cryo-EM | 6E3Y | 6E3Y_refined | 3.3 | R | Active | 100 | 75 | Gs | αs | - | 48 | - | Nanobody-35 RAMP1 |
Calcitonin gene-related peptide 1
|
peptide | Agonist | - | - | No | No | Liang YL, Khoshouei M, Deganutti G, Glukhova A, Koole C, Peat TS, Radjainia M, Plitzko JM, Baumeister W, Miller LJ, Hay DL, Christopoulos A, Reynolds CA, Wootten D, Sexton PM | 10.1038/S41586-018-0535-Y | 2018-09-19 | Yes | |
| 5HT2B | 5-HT2B | 5-Hydroxytryptamine | A | Human | X-ray | 6DRZ | 6DRZ_refined | 3.1 | A | Intermediate | 55 | 61 | - | - | - | - | BRIL | - |
methysergide
|
small-molecule | Antagonist | 5-hydroxytryptamine | small-molecule | No | No | McCorvy JD, Wacker D, Wang S, Agegnehu B, Liu J, Lansu K, Tribo AR, Olsen RHJ, Che T, Jin J, Roth BL | 10.1038/s41594-018-0116-7 | 2018-08-29 | Yes | |
| 5HT2B | 5-HT2B | 5-Hydroxytryptamine | A | Human | X-ray | 6DRY | 6DRY_refined | 2.9 | A | Intermediate | 55 | 60 | - | - | - | - | BRIL | - |
methylergonovine
|
small-molecule | Agonist | 5-hydroxytryptamine | small-molecule | No | No | McCorvy JD, Wacker D, Wang S, Agegnehu B, Liu J, Lansu K, Tribo AR, Olsen RHJ, Che T, Jin J, Roth BL | 10.1038/s41594-018-0116-7 | 2018-08-29 | Yes | |
| 5HT2B | 5-HT2B | 5-Hydroxytryptamine | A | Human | X-ray | 6DS0 | 6DS0_refined | 3.2 | A | Intermediate | 55 | 59 | - | - | - | - | BRIL | - |
LY266097
|
small-molecule | Antagonist | 5-hydroxytryptamine | small-molecule | No | No | McCorvy JD, Wacker D, Wang S, Agegnehu B, Liu J, Lansu K, Tribo AR, Olsen RHJ, Che T, Jin J, Roth BL | 10.1038/s41594-018-0116-7 | 2018-08-29 | Yes | |
| 5HT2B | 5-HT2B | 5-Hydroxytryptamine | A | Human | X-ray | 6DRX | 6DRX_refined | 3.1 | A | Intermediate | 55 | 59 | - | - | - | - | BRIL | - |
lisuride
|
small-molecule | Antagonist | 5-hydroxytryptamine | small-molecule | No | No | McCorvy JD, Wacker D, Wang S, Agegnehu B, Liu J, Lansu K, Tribo AR, Olsen RHJ, Che T, Jin J, Roth BL | 10.1038/s41594-018-0116-7 | 2018-08-29 | Yes | |
| FZD4 | FZD4 | Frizzled | F | Human | X-ray | 6BD4 | 6BD4_refined | 2.4 | A | Inactive | 19 | 61 | - | - | - | - | Rubredoxin | - |
Apo (no ligand)
|
none | Apo (no ligand) | - | - | No | No | Yang S, Wu Y, Xu TH, de Waal PW, He Y, Pu M, Chen Y, DeBruine ZJ, Zhang B, Zaidi SA, Popov P, Guo Y, Han GW, Lu Y, Suino-Powell K, Dong S, Harikumar KG, Miller LJ, Katritch V, Xu HE, Shui W, Stevens RC, Melcher K, Zhao S, Xu F | 10.1038/S41586-018-0447-X | 2018-08-22 | Yes | |
| AGTR2 | AT2 | Angiotensin | A | Human | X-ray | 5XJM | 5XJM_refined | 3.2 | A | Active | 100 | 78 | - | - | - | - | BRIL | Fab |
CHEMBL404594
|
protein | Agonist | angiotensin III, angiotensin-(1-7), angiotensin II | peptide | No | No | Asada H, Horita S, Hirata K, Shiroishi M, Shiimura Y, Iwanari H, Hamakubo T, Shimamura T, Nomura N, Kusano-Arai O, Uemura T, Suno C, Kobayashi T, Iwata S | 10.1038/S41594-018-0079-8 | 2018-07-11 | Yes | |
| 5HT1B | 5-HT1B | 5-Hydroxytryptamine | A | Human | Cryo-EM | 6G79 | - | 3.8 | S | Active | 100 | 67 | Gi/o | αo | - | 59 | - | - |
donitriptan
|
small-molecule | Agonist | 5-HT-moduline, tryptamine, 5-hydroxytryptamine | small-molecule | No | No | Garcia-Nafria J, Nehme R, Edwards PC, Tate CG | 10.1038/S41586-018-0241-9 | 2018-06-20 | Yes | |
| AA1R | A1 | Adenosine | A | Human | Cryo-EM | 6D9H | 6D9H_refined | 3.6 | R | Active | 100 | 88 | Gi/o | αi2 | - | 59 | - | - |
adenosine
|
small-molecule | Agonist | adenosine | small-molecule | No | No | Draper-Joyce CJ, Khoshouei M, Thal DM, Liang YL, Nguyen ATN, Furness SGB, Venugopal H, Baltos JA, Plitzko JM, Danev R, Baumeister W, May LT, Wootten D, Sexton PM, Glukhova A, Christopoulos A | 10.1038/S41586-018-0236-6 | 2018-06-20 | Yes | |
| OPSD | Rhodopsin | Opsins | A | Human | Cryo-EM | 6CMO | 6CMO_refined | 4.5 | R | Active | 76 | 92 | Gi/o | αi1 | - | 100 | BRIL | Fab |
Apo (no ligand)
|
none | Apo (no ligand) | - | - | No | No | Kang Y, Kuybeda O, de Waal PW, Mukherjee S, Van Eps N, Dutka P, Zhou XE, Bartesaghi A, Erramilli S, Morizumi T, Gu X, Yin Y, Liu P, Jiang Y, Meng X, Zhao G, Melcher K, Ernst OP, Kossiakoff AA, Subramaniam S, Xu HE | 10.1038/S41586-018-0215-Y | 2018-06-20 | Yes | |
| PTAFR | PAF | Platelet-activating factor | A | Human | X-ray | 5ZKQ | 5ZKQ_refined | 2.9 | B | Active | 56 | 83 | - | - | - | - | T4-Lysozyme | - |
ABT-491
|
small-molecule | Inverse agonist | PAF | small-molecule | No | No | - | - | 2018-06-20 | Yes | |
| PTAFR | PAF | Platelet-activating factor | A | Human | X-ray | 5ZKP | 5ZKP_refined | 2.8 | A | Other | - | 85 | - | - | - | - | Flavodoxin | - |
foropafant
|
small-molecule | Antagonist | PAF | small-molecule | No | No | Cao C, Tan Q, Xu C, He L, Yang L, Zhou Y, Zhou Y, Qiao A, Lu M, Yi C, Han GW, Wang X, Li X, Yang H, Rao Z, Jiang H, Zhao Y, Liu J, Stevens RC, Zhao Q, Zhang XC, Wu B | 10.1038/S41594-018-0068-Y | 2018-06-20 | Yes | |
| OPRM | μ | Opioid | A | Mouse | Cryo-EM | 6DDF | - | 3.5 | R | Active | 100 | 71 | Gi/o | αi1 | - | 61 | - | - |
DAMGO
|
peptide | Agonist | - | - | No | No | Koehl A, Hu H, Maeda S, Zhang Y, Qu Q, Paggi JM, Latorraca NR, Hilger D, Dawson R, Matile H, Schertler GFX, Granier S, Weis WI, Dror RO, Manglik A, Skiniotis G, Kobilka BK | 10.1038/S41586-018-0219-7 | 2018-06-13 | Yes | |
| OPRM | μ | Opioid | A | Mouse | Cryo-EM | 6DDE | - | 3.5 | R | Active | 100 | 71 | Gi/o | αi1 | - | 61 | - | Antibody |
DAMGO
|
peptide | Agonist | - | - | No | No | Koehl A, Hu H, Maeda S, Zhang Y, Qu Q, Paggi JM, Latorraca NR, Hilger D, Dawson R, Matile H, Schertler GFX, Granier S, Weis WI, Dror RO, Manglik A, Skiniotis G, Kobilka BK | 10.1038/S41586-018-0219-7 | 2018-06-13 | Yes | |
| Q80KM9 | US28 | Unclassified | A | strain AD169 | X-ray | 5WB1 | 5WB1_refined | 3.5 | A | Active | 100 | 82 | - | - | - | - | - | Nanobody |
Apo (no ligand)
|
none | Apo (no ligand) | - | - | No | No | Miles TF, Spiess K, Jude KM, Tsutsumi N, Burg JS, Ingram JR, Waghray D, Hjorto GM, Larsen O, Ploegh HL, Rosenkilde MM, Garcia KC | 10.7554/ELIFE.35850 | 2018-06-13 | Yes | |
| Q80KM9 | US28 | Unclassified | A | strain AD169 | X-ray | 5WB2 | 5WB2_refined | 3.5 | A | Active | 100 | 82 | - | - | - | - | - | Nanobody |
CX3CL1
|
peptide | Agonist | - | - | No | No | Miles TF, Spiess K, Jude KM, Tsutsumi N, Burg JS, Ingram JR, Waghray D, Hjorto GM, Larsen O, Ploegh HL, Rosenkilde MM, Garcia KC | 10.7554/ELIFE.35850 | 2018-06-13 | Yes | |
| C5AR1 | C5a1 | Complement peptide | A | Human | X-ray | 6C1R | 6C1R_refined | 2.2 | B | Inactive | 6 | 83 | - | - | - | - | BRIL | - |
PMX53
avacopan |
peptide small-molecule |
Antagonist NAM |
C5a, ribosomal protein S19, C5a des-Arg, C3a | peptide | No | No | Liu H, Kim HR, Deepak RNVK, Wang L, Chung KY, Fan H, Wei Z, Zhang C | 10.1038/S41594-018-0067-Z | 2018-05-30 | Yes | |
| C5AR1 | C5a1 | Complement peptide | A | Human | X-ray | 6C1Q | 6C1Q_refined | 2.9 | B | Inactive | 6 | 82 | - | - | - | - | BRIL | - |
PMX53
NDT9513727 |
peptide small-molecule |
Antagonist NAM |
C5a, ribosomal protein S19, C5a des-Arg, C3a | peptide | No | No | Liu H, Kim HR, Deepak RNVK, Wang L, Chung KY, Fan H, Wei Z, Zhang C | 10.1038/S41594-018-0067-Z | 2018-05-30 | Yes | |
| Q98SW5 | SMO | Frizzled | F | African clawed frog | X-ray | 6D32 | 6D32_refined | 3.8 | A | Active | 65 | 58 | - | - | - | - | BRIL | - |
cyclopamine
|
small-molecule | Agonist (partial) | - | - | No | No | Huang P, Zheng S, Wierbowski BM, Kim Y, Nedelcu D, Aravena L, Liu J, Kruse AC, Salic A | 10.1016/J.CELL.2018.04.029 | 2018-05-23 | Yes | |
| Q98SW5 | SMO | Frizzled | F | African clawed frog | X-ray | 6D35 | 6D35_refined | 3.9 | A | Active | 65 | 58 | - | - | - | - | BRIL | - |
Cholesterol
|
small-molecule | Agonist | - | - | No | No | Huang P, Zheng S, Wierbowski BM, Kim Y, Nedelcu D, Aravena L, Liu J, Kruse AC, Salic A | 10.1016/J.CELL.2018.04.029 | 2018-05-23 | Yes | |
| AA2AR | A2A | Adenosine | A | Human | Cryo-EM | 6GDG | 6GDG_refined | 4.1 | A | Active | 100 | 64 | Gs | αs | - | 57 | TrxA | Nanobody-35 |
NECA
|
small-molecule | Agonist | adenosine | small-molecule | No | No | Garcia-Nafria J, Lee Y, Bai X, Carpenter B, Tate CG | 10.7554/ELIFE.35946 | 2018-05-16 | Yes | |
| FFAR1 | FFA1 | Free fatty acid | A | Human | X-ray | 5KW2 | 5KW2_refined | 2.8 | A | Active | 56 | 82 | - | - | - | - | T4-Lysozyme | - |
(3~{S})-3-cyclopropyl-3-[2-[1-[2-[2,2-dimethylpropyl-(6-methylpyridin-2-yl)carbamoyl]-5-methoxy-phenyl]piperidin-4-yl]-1-benzofuran-6-yl]propanoic acid
|
small-molecule | Allosteric agonist | myristic acid, oleic acid, docosahexaenoic acid, α-linolenic acid | small-molecule | No | No | Ho JD, Chau B, Rodgers L, Lu F, Wilbur KL, Otto KA, Chen Y, Song M, Riley JP, Yang HC, Reynolds NA, Kahl SD, Lewis AP, Groshong C, Madsen RE, Conners K, Lineswala JP, Gheyi T, Saflor MD, Lee MR, Benach J, Baker KA, Montrose-Rafizadeh C, Genin MJ, Miller AR, Hamdouchi C | 10.1038/S41467-017-01240-W | 2018-05-02 | Yes | |
| NPY1R | Y1 | Neuropeptide Y | A | Human | X-ray | 5ZBH | 5ZBH_refined | 3.0 | A | Inactive | 1 | 78 | - | - | - | - | T4-Lysozyme | - |
CHEMBL2046866
|
small-molecule | Antagonist | peptide YY, pancreatic polypeptide, neuropeptide Y | peptide | No | No | Yang Z, Han S, Keller M, Kaiser A, Bender BJ, Bosse M, Burkert K, Kogler LM, Wifling D, Bernhardt G, Plank N, Littmann T, Schmidt P, Yi C, Li B, Ye S, Zhang R, Xu B, Larhammar D, Stevens RC, Huster D, Meiler J, Zhao Q, Beck-Sickinger AG, Buschauer A, Wu B | 10.1038/S41586-018-0046-X | 2018-04-25 | Yes | |
| NPY1R | Y1 | Neuropeptide Y | A | Human | X-ray | 5ZBQ | 5ZBQ_refined | 2.7 | A | Inactive | 1 | 80 | - | - | - | - | T4-Lysozyme | - |
CHEMBL3747822
|
small-molecule | Antagonist | peptide YY, pancreatic polypeptide, neuropeptide Y | peptide | No | No | Yang Z, Han S, Keller M, Kaiser A, Bender BJ, Bosse M, Burkert K, Kogler LM, Wifling D, Bernhardt G, Plank N, Littmann T, Schmidt P, Yi C, Li B, Ye S, Zhang R, Xu B, Larhammar D, Stevens RC, Huster D, Meiler J, Zhao Q, Beck-Sickinger AG, Buschauer A, Wu B | 10.1038/S41586-018-0046-X | 2018-04-25 | Yes | |
| OPSD | Rhodopsin | Opsins | A | Bovine | X-ray | 6FKD | 6FKD_refined | 2.5 | A | Active | 98 | 94 | - | - | - | - | - | - |
5-chloro-2-(2-oxo-2-spiro[1,3-benzodioxole-2,4'-piperidine]-1'-ylethyl)-3H-pyridin-6-one
|
small-molecule | Agonist | - | - | No | No | Mattle D, Kuhn B, Aebi J, Bedoucha M, Kekilli D, Grozinger N, Alker A, Rudolph MG, Schmid G, Schertler GFX, Hennig M, Standfuss J, Dawson RJP | 10.1073/PNAS.1718084115 | 2018-04-04 | Yes | |
| OPSD | Rhodopsin | Opsins | A | Bovine | X-ray | 6FK7 | 6FK7_refined | 2.6 | A | Active | 98 | 94 | - | - | - | - | - | - |
(2~{S})-2-(4-chlorophenyl)-3-methyl-1-spiro[1,3-benzodioxole-2,4'-piperidine]-1'-yl-butan-1-one
|
small-molecule | Agonist | - | - | No | No | - | - | 2018-04-04 | Yes | |
| OPSD | Rhodopsin | Opsins | A | Bovine | X-ray | 6FK8 | 6FK8_refined | 2.9 | A | Active | 98 | 94 | - | - | - | - | - | - |
(2~{R},3~{S})-3-azanyl-2-(4-chlorophenyl)-1-spiro[1,3-benzodioxole-2,4'-piperidine]-1'-yl-butan-1-one
|
small-molecule | Agonist | - | - | No | No | Mattle D, Kuhn B, Aebi J, Bedoucha M, Kekilli D, Grozinger N, Alker A, Rudolph MG, Schmid G, Schertler GFX, Hennig M, Standfuss J, Dawson RJP | 10.1073/PNAS.1718084115 | 2018-04-04 | Yes | |
| OPSD | Rhodopsin | Opsins | A | Bovine | X-ray | 6FKC | 6FKC_refined | 2.5 | A | Active | 98 | 94 | - | - | - | - | - | - |
3-[1'-[(2~{S})-2-(4-chlorophenyl)-3-methyl-butanoyl]spiro[1,3-benzodioxole-2,4'-piperidine]-5-yl]propanoic acid
|
small-molecule | Agonist | - | - | No | No | Mattle D, Kuhn B, Aebi J, Bedoucha M, Kekilli D, Grozinger N, Alker A, Rudolph MG, Schmid G, Schertler GFX, Hennig M, Standfuss J, Dawson RJP | 10.1073/PNAS.1718084115 | 2018-04-04 | Yes | |
| OPSD | Rhodopsin | Opsins | A | Bovine | X-ray | 6FKA | 6FKA_refined | 2.7 | A | Active | 98 | 94 | - | - | - | - | - | - |
(2~{S})-2-(3,4-dichlorophenyl)-3-methyl-1-spiro[1,3-benzodioxole-2,4'-piperidine]-1'-yl-butan-1-one
|
small-molecule | Agonist | - | - | No | No | Mattle D, Kuhn B, Aebi J, Bedoucha M, Kekilli D, Grozinger N, Alker A, Rudolph MG, Schmid G, Schertler GFX, Hennig M, Standfuss J, Dawson RJP | 10.1073/PNAS.1718084115 | 2018-04-04 | Yes | |
| OPSD | Rhodopsin | Opsins | A | Bovine | X-ray | 6FKB | 6FKB_refined | 3.0 | A | Active | 98 | 94 | - | - | - | - | - | - |
2-(4-Chlorophenyl)-1-spiro[1,3-benzodioxole-2,4'-piperidine]-1'-yl-ethanone
|
small-molecule | Agonist | - | - | No | No | Mattle D, Kuhn B, Aebi J, Bedoucha M, Kekilli D, Grozinger N, Alker A, Rudolph MG, Schmid G, Schertler GFX, Hennig M, Standfuss J, Dawson RJP | 10.1073/PNAS.1718084115 | 2018-04-04 | Yes | |
| OPSD | Rhodopsin | Opsins | A | Bovine | X-ray | 6FK9 | 6FK9_refined | 2.6 | A | Active | 98 | 94 | - | - | - | - | - | - |
(2~{S})-3-methyl-2-phenyl-1-spiro[1,3-benzodioxole-2,4'-piperidine]-1'-yl-butan-1-one
|
small-molecule | Agonist | - | - | No | No | Mattle D, Kuhn B, Aebi J, Bedoucha M, Kekilli D, Grozinger N, Alker A, Rudolph MG, Schmid G, Schertler GFX, Hennig M, Standfuss J, Dawson RJP | 10.1073/PNAS.1718084115 | 2018-04-04 | Yes | |
| OPSD | Rhodopsin | Opsins | A | Bovine | X-ray | 6FK6 | 6FK6_refined | 2.4 | A | Active | 98 | 94 | - | - | - | - | - | - |
COMPOUND SUMMARY
|
small-molecule | Agonist | - | - | No | No | Mattle D, Kuhn B, Aebi J, Bedoucha M, Kekilli D, Grozinger N, Alker A, Rudolph MG, Schmid G, Schertler GFX, Hennig M, Standfuss J, Dawson RJP | 10.1073/PNAS.1718084115 | 2018-04-04 | Yes | |
| DRD2 | D2 | Dopamine | A | Human | X-ray | 6CM4 | 6CM4_refined | 2.9 | A | Inactive | 1 | 59 | - | - | - | - | T4-Lysozyme | - |
risperidone
|
small-molecule | Inverse agonist | dopamine | small-molecule | No | No | Wang S, Che T, Levit A, Shoichet BK, Wacker D, Roth BL | 10.1038/NATURE25758 | 2018-03-14 | Yes | |
| GRM5 | mGlu5 | Metabotropic glutamate | C | Human | X-ray | 6FFH | 6FFH_refined | 2.7 | A | Inactive | - | 21 | - | - | - | - | T4-Lysozyme | - |
fenobam
|
small-molecule | NAM | L-glutamic acid | small-molecule | No | No | Christopher JA, Orgovan Z, Congreve M, Dore AS, Errey JC, Marshall FH, Mason JS, Okrasa K, Rucktooa P, Serrano-Vega MJ, Ferenczy GG, Keseru GM | 10.1021/ACS.JMEDCHEM.7B01722 | 2018-03-07 | Yes | |
| GRM5 | mGlu5 | Metabotropic glutamate | C | Human | X-ray | 6FFI | 6FFI_refined | 2.2 | A | Inactive | - | 20 | - | - | - | - | T4-Lysozyme | - |
methoxy-MPEP
|
small-molecule | NAM | L-glutamic acid | small-molecule | No | No | - | - | 2018-03-07 | Yes | |
| AA2AR | A2A | Adenosine | A | Human | X-ray | 5WF5 | 5WF5_refined | 2.6 | A | Active | 69 | 69 | - | - | - | - | T4-Lysozyme | - |
UK-432,097
|
small-molecule | Agonist | adenosine | small-molecule | No | No | White KL, Eddy MT, Gao ZG, Han GW, Lian T, Deary A, Patel N, Jacobson KA, Katritch V, Stevens RC | 10.1016/J.STR.2017.12.013 | 2018-02-21 | Yes | |
| AA2AR | A2A | Adenosine | A | Human | X-ray | 5WF6 | 5WF6_refined | 2.9 | A | Active | 69 | 68 | - | - | - | - | T4-Lysozyme | - |
UK-432,097
|
small-molecule | Agonist | adenosine | small-molecule | No | No | White KL, Eddy MT, Gao ZG, Han GW, Lian T, Deary A, Patel N, Jacobson KA, Katritch V, Stevens RC | 10.1016/J.STR.2017.12.013 | 2018-02-21 | Yes | |
| GLP1R | GLP-1 | Glucagon | B1 | Human | Cryo-EM | 6B3J | - | 3.3 | R | Active | 100 | 82 | Gs | αs | - | 49 | - | - |
Exendin-P5
|
peptide | Agonist | glucagon-like peptide 1-(7-36) amide, glucagon, glucagon-like peptide 1-(7-37) | peptide | No | No | Liang YL, Khoshouei M, Glukhova A, Furness SGB, Zhao P, Clydesdale L, Koole C, Truong TT, Thal DM, Lei S, Radjainia M, Danev R, Baumeister W, Wang MW, Miller LJ, Christopoulos A, Sexton PM, Wootten D | 10.1038/NATURE25773 | 2018-02-21 | Yes | |
| 5HT2C | 5-HT2C | 5-Hydroxytryptamine | A | Human | X-ray | 6BQG | 6BQG_refined | 3.0 | A | Active | 86 | 62 | - | - | - | - | BRIL | - |
ergotamine
|
small-molecule | Agonist | 5-hydroxytryptamine | small-molecule | No | No | Peng Y, McCorvy JD, Harpsoe K, Lansu K, Yuan S, Popov P, Qu L, Pu M, Che T, Nikolajsen LF, Huang XP, Wu Y, Shen L, Bjorn-Yoshimoto WE, Ding K, Wacker D, Han GW, Cheng J, Katritch V, Jensen AA, Hanson MA, Zhao S, Gloriam DE, Roth BL, Stevens RC, Liu ZJ | 10.1016/j.cell.2018.01.001 | 2018-02-14 | Yes | |
| 5HT2C | 5-HT2C | 5-Hydroxytryptamine | A | Human | X-ray | 6BQH | 6BQH_refined | 2.7 | A | Inactive | 1 | 63 | - | - | - | - | BRIL | - |
ritanserin
|
small-molecule | Inverse agonist | 5-hydroxytryptamine | small-molecule | No | No | Peng Y, McCorvy JD, Harpsoe K, Lansu K, Yuan S, Popov P, Qu L, Pu M, Che T, Nikolajsen LF, Huang XP, Wu Y, Shen L, Bjorn-Yoshimoto WE, Ding K, Wacker D, Han GW, Cheng J, Katritch V, Jensen AA, Hanson MA, Zhao S, Gloriam DE, Roth BL, Stevens RC, Liu ZJ | 10.1016/j.cell.2018.01.001 | 2018-02-14 | Yes | |
| 5HT1B | 5-HT1B | 5-Hydroxytryptamine | A | Human | X-ray | 5V54 | 5V54_refined | 3.9 | A | Inactive | 16 | 71 | - | - | - | - | BRIL | - |
CHEMBL428892
|
small-molecule | Antagonist | 5-HT-moduline, tryptamine, 5-hydroxytryptamine | small-molecule | No | No | - | - | 2018-02-07 | Yes | |
| AA2AR | A2A | Adenosine | A | Human | X-ray | 5OLH | 5OLH_refined | 2.6 | A | Inactive | 1 | 72 | - | - | - | - | BRIL | - |
vipadenant
|
small-molecule | Antagonist | adenosine | small-molecule | No | No | Rucktooa P, Cheng RKY, Segala E, Geng T, Errey JC, Brown GA, Cooke RM, Marshall FH, Dore AS | 10.1038/S41598-017-18570-W | 2018-01-17 | Yes | |
| AA2AR | A2A | Adenosine | A | Human | X-ray | 5OM1 | 5OM1_refined | 2.1 | A | Inactive | 1 | 72 | - | - | - | - | BRIL | - |
CHEMBL2024114
|
small-molecule | Antagonist | adenosine | small-molecule | No | No | Rucktooa P, Cheng RKY, Segala E, Geng T, Errey JC, Brown GA, Cooke RM, Marshall FH, Dore AS | 10.1038/S41598-017-18570-W | 2018-01-17 | Yes | |
| AA2AR | A2A | Adenosine | A | Human | X-ray | 5OLV | 5OLV_refined | 2.0 | A | Inactive | 1 | 72 | - | - | - | - | BRIL | - |
CHEMBL1671936
|
small-molecule | Antagonist | adenosine | small-molecule | No | No | Rucktooa P, Cheng RKY, Segala E, Geng T, Errey JC, Brown GA, Cooke RM, Marshall FH, Dore AS | 10.1038/S41598-017-18570-W | 2018-01-17 | Yes | |
| AA2AR | A2A | Adenosine | A | Human | X-ray | 5OM4 | 5OM4_refined | 2.0 | A | Inactive | 1 | 72 | - | - | - | - | BRIL | - |
CHEMBL2024114
|
small-molecule | Antagonist | adenosine | small-molecule | No | No | Rucktooa P, Cheng RKY, Segala E, Geng T, Errey JC, Brown GA, Cooke RM, Marshall FH, Dore AS | 10.1038/S41598-017-18570-W | 2018-01-17 | Yes | |
| AA2AR | A2A | Adenosine | A | Human | X-ray | 5OLO | 5OLO_refined | 3.1 | A | Inactive | 1 | 72 | - | - | - | - | BRIL | - |
tozadenant
|
small-molecule | Antagonist | adenosine | small-molecule | No | No | Rucktooa P, Cheng RKY, Segala E, Geng T, Errey JC, Brown GA, Cooke RM, Marshall FH, Dore AS | 10.1038/S41598-017-18570-W | 2018-01-17 | Yes | |
| AA2AR | A2A | Adenosine | A | Human | X-ray | 5OLG | 5OLG_refined | 1.9 | A | Inactive | 1 | 72 | - | - | - | - | BRIL | - |
ZM-241385
|
small-molecule | Antagonist | adenosine | small-molecule | No | No | Rucktooa P, Cheng RKY, Segala E, Geng T, Errey JC, Brown GA, Cooke RM, Marshall FH, Dore AS | 10.1038/S41598-017-18570-W | 2018-01-17 | Yes | |
| AA2AR | A2A | Adenosine | A | Human | X-ray | 5OLZ | 5OLZ_refined | 1.9 | A | Inactive | 1 | 72 | - | - | - | - | BRIL | - |
CHEMBL2024114
|
small-molecule | Antagonist | adenosine | small-molecule | No | No | Rucktooa P, Cheng RKY, Segala E, Geng T, Errey JC, Brown GA, Cooke RM, Marshall FH, Dore AS | 10.1038/S41598-017-18570-W | 2018-01-17 | Yes | |
| GLR | glucagon | Glucagon | B1 | Human | X-ray | 5YQZ | 5YQZ_refined | 3.0 | R | Inactive | 2 | 83 | - | - | - | - | T4-Lysozyme | - |
NNC1702
|
peptide | Agonist (partial) | glucagon | peptide | No | No | Zhang H, Qiao A, Yang L, Van Eps N, Frederiksen KS, Yang D, Dai A, Cai X, Zhang H, Yi C, Cao C, He L, Yang H, Lau J, Ernst OP, Hanson MA, Stevens RC, Wang MW, Reedtz-Runge S, Jiang H, Zhao Q, Wu B | 10.1038/NATURE25153 | 2018-01-17 | Yes | |
| OPRK | κ | Opioid | A | Human | X-ray | 6B73 | 6B73_refined | 3.1 | A | Active | 100 | 73 | - | - | - | - | BRIL | Nanobody |
CHEMBL5431513
|
small-molecule | Agonist | dynorphin B, dynorphin A-(1-13), dynorphin A-(1-8), β-endorphin, β-neoendorphin, α-neoendorphin, [Met]enkephalin, dynorphin A, [Leu]enkephalin, big dynorphin | peptide | No | No | Che T, Majumdar S, Zaidi SA, Ondachi P, McCorvy JD, Wang S, Mosier PD, Uprety R, Vardy E, Krumm BE, Han GW, Lee MY, Pardon E, Steyaert J, Huang XP, Strachan RT, Tribo AR, Pasternak GW, Carroll FI, Stevens RC, Cherezov V, Katritch V, Wacker D, Roth BL | 10.1016/J.CELL.2017.12.011 | 2018-01-17 | Yes | |
| AA2AR | A2A | Adenosine | A | Human | X-ray | 6AQF | 6AQF_refined | 2.5 | A | Inactive | 1 | 72 | - | - | - | - | BRIL | - |
ZM-241385
|
small-molecule | Antagonist | adenosine | small-molecule | No | No | Eddy MT, Lee MY, Gao ZG, White KL, Didenko T, Horst R, Audet M, Stanczak P, McClary KM, Han GW, Jacobson KA, Stevens RC, Wuthrich K | 10.1016/J.CELL.2017.12.004 | 2018-01-10 | Yes | |
| C5AR1 | C5a1 | Complement peptide | A | Human | X-ray | 5O9H | 5O9H_refined | 2.7 | A | Inactive | 6 | 84 | - | - | - | - | - | - |
NDT9513727
|
small-molecule | Antagonist | C5a, ribosomal protein S19, C5a des-Arg, C3a | peptide | No | No | Robertson N, Rappas M, Dore AS, Brown J, Bottegoni G, Koglin M, Cansfield J, Jazayeri A, Cooke RM, Marshall FH | 10.1038/NATURE25025 | 2018-01-10 | Yes | |
| Q9WTK1 | BLT1 | Leukotriene | A | Guinea pig | X-ray | 5X33 | 5X33_refined | 3.7 | A | Inactive | 9 | 78 | - | - | - | - | T4-Lysozyme | - |
BIIL 260
|
small-molecule | Antagonist | - | - | No | No | Hori T, Okuno T, Hirata K, Yamashita K, Kawano Y, Yamamoto M, Hato M, Nakamura M, Shimizu T, Yokomizo T, Miyano M, Yokoyama S | 10.1038/NCHEMBIO.2547 | 2018-01-03 | Yes | |
| AA2AR | A2A | Adenosine | A | Human | X-ray | 5VRA | 5VRA_refined | 2.4 | A | Inactive | 1 | 72 | - | - | - | - | BRIL | - |
ZM-241385
|
small-molecule | Antagonist | adenosine | small-molecule | No | No | Broecker J, Morizumi T, Ou WL, Klingel V, Kuo A, Kissick DJ, Ishchenko A, Lee MY, Xu S, Makarov O, Cherezov V, Ogata CM, Ernst OP | 10.1038/NPROT.2017.135 | 2017-12-13 | Yes | |
| OPSD | Rhodopsin | Opsins | A | Bovine | X-ray | 5WKT | 5WKT_refined | 3.2 | A | Active | 100 | 94 | Gi/o | αt1 | Only H5 | 3 | - | - |
B-Octylglucoside
|
small-molecule | unknown | - | - | No | No | Broecker J, Morizumi T, Ou WL, Klingel V, Kuo A, Kissick DJ, Ishchenko A, Lee MY, Xu S, Makarov O, Cherezov V, Ogata CM, Ernst OP | 10.1038/NPROT.2017.135 | 2017-12-13 | Yes | |
| OX2R | OX2 | Orexin | A | Human | X-ray | 5WS3 | 5WS3_refined | 2.3 | A | Inactive | 1 | 70 | - | - | - | - | Glycogen synthase | - |
EMPA
|
small-molecule | Antagonist | orexin-B, orexin-A | peptide | No | No | Suno R, Kimura KT, Nakane T, Yamashita K, Wang J, Fujiwara T, Yamanaka Y, Im D, Horita S, Tsujimoto H, Tawaramoto MS, Hirokawa T, Nango E, Tono K, Kameshima T, Hatsui T, Joti Y, Yabashi M, Shimamoto K, Yamamoto M, Rosenbaum DM, Iwata S, Shimamura T, Kobayashi T | 10.1016/J.STR.2017.11.005 | 2017-12-13 | Yes | |
| OX2R | OX2 | Orexin | A | Human | X-ray | 5WQC | 5WQC_refined | 2.0 | A | Inactive | 1 | 68 | - | - | - | - | Glycogen synthase | - |
EMPA
|
small-molecule | Antagonist | orexin-B, orexin-A | peptide | No | No | Suno R, Kimura KT, Nakane T, Yamashita K, Wang J, Fujiwara T, Yamanaka Y, Im D, Horita S, Tsujimoto H, Tawaramoto MS, Hirokawa T, Nango E, Tono K, Kameshima T, Hatsui T, Joti Y, Yabashi M, Shimamoto K, Yamamoto M, Rosenbaum DM, Iwata S, Shimamura T, Kobayashi T | 10.1016/J.STR.2017.11.005 | 2017-11-29 | Yes | |
| DRD4 | D4 | Dopamine | A | Human | X-ray | 5WIV | - | 2.1 | A | Inactive | 1 | 65 | - | - | - | - | BRIL | - |
[3H]NEMONAPRIDE
|
small-molecule | Antagonist | dopamine | small-molecule | No | No | Wang S, Wacker D, Levit A, Che T, Betz RM, McCorvy JD, Venkatakrishnan AJ, Huang XP, Dror RO, Shoichet BK, Roth BL | 10.1126/SCIENCE.AAN5468 | 2017-10-18 | Yes | |
| DRD4 | D4 | Dopamine | A | Human | X-ray | 5WIU | - | 2.0 | A | Inactive | 1 | 64 | - | - | - | - | BRIL | - |
[3H]NEMONAPRIDE
|
small-molecule | Antagonist | dopamine | small-molecule | No | No | Wang S, Wacker D, Levit A, Che T, Betz RM, McCorvy JD, Venkatakrishnan AJ, Huang XP, Dror RO, Shoichet BK, Roth BL | 10.1126/SCIENCE.AAN5468 | 2017-10-18 | Yes | |
| AA2AR | A2A | Adenosine | A | Human | X-ray | 5NM2 | 5NM2_refined | 2.0 | A | Inactive | 1 | 72 | - | - | - | - | BRIL | - |
ZM-241385
|
small-molecule | Antagonist | adenosine | small-molecule | No | No | Weinert T, Olieric N, Cheng R, Brunle S, James D, Ozerov D, Gashi D, Vera L, Marsh M, Jaeger K, Dworkowski F, Panepucci E, Basu S, Skopintsev P, Dore AS, Geng T, Cooke RM, Liang M, Prota AE, Panneels V, Nogly P, Ermler U, Schertler G, Hennig M, Steinmetz MO, Wang M, Standfuss J | 10.1038/S41467-017-00630-4 | 2017-09-27 | Yes | |
| AA2AR | A2A | Adenosine | A | Human | X-ray | 5NM4 | - | 1.7 | A | Inactive | 1 | 73 | - | - | - | - | BRIL | - |
ZM-241385
|
small-molecule | Antagonist | adenosine | small-molecule | No | No | Weinert T, Olieric N, Cheng R, Brunle S, James D, Ozerov D, Gashi D, Vera L, Marsh M, Jaeger K, Dworkowski F, Panepucci E, Basu S, Skopintsev P, Dore AS, Geng T, Cooke RM, Liang M, Prota AE, Panneels V, Nogly P, Ermler U, Schertler G, Hennig M, Steinmetz MO, Wang M, Standfuss J | 10.1038/S41467-017-00630-4 | 2017-09-27 | Yes | |
| AA2AR | A2A | Adenosine | A | Human | X-ray | 5NLX | - | 2.1 | A | Inactive | 1 | 73 | - | - | - | - | BRIL | - |
ZM-241385
|
small-molecule | Antagonist | adenosine | small-molecule | No | No | Weinert T, Olieric N, Cheng R, Brunle S, James D, Ozerov D, Gashi D, Vera L, Marsh M, Jaeger K, Dworkowski F, Panepucci E, Basu S, Skopintsev P, Dore AS, Geng T, Cooke RM, Liang M, Prota AE, Panneels V, Nogly P, Ermler U, Schertler G, Hennig M, Steinmetz MO, Wang M, Standfuss J | 10.1038/S41467-017-00630-4 | 2017-09-27 | Yes | |
| ADRB2 | β2 | Adrenoceptors | A | Human | X-ray | 5X7D | 5X7D_refined | 2.7 | A | Inactive | 0 | 68 | - | - | - | - | T4-Lysozyme | - |
4-carbamoyl-N-[(2R)-2-cyclohexyl-2-phenylacetyl]-L-phenylalanyl-3-bromo-N-methyl-L-phenylalaninamide
Carazolol |
small-molecule small-molecule |
Allosteric antagonist Antagonist |
Zn2+, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline | small-molecule | No | No | Liu X, Ahn S, Kahsai AW, Meng KC, Latorraca NR, Pani B, Venkatakrishnan AJ, Masoudi A, Weis WI, Dror RO, Chen X, Lefkowitz RJ, Kobilka BK | 10.1038/NATURE23652 | 2017-08-16 | Yes | |
| EDNRB | ETB | Endothelin | A | Human | X-ray | 5XPR | 5XPR_refined | 3.6 | A | Inactive | 3 | 69 | - | - | - | - | T4-Lysozyme | - |
bosentan
|
small-molecule | Antagonist | endothelin-2, endothelin-3, endothelin-1 | peptide | No | No | Shihoya W, Nishizawa T, Yamashita K, Inoue A, Hirata K, Kadji FMN, Okuta A, Tani K, Aoki J, Fujiyoshi Y, Doi T, Nureki O | 10.1038/NSMB.3450 | 2017-08-16 | Yes | |
| EDNRB | ETB | Endothelin | A | Human | X-ray | 5X93 | 5X93_refined | 2.2 | A | Inactive | 3 | 71 | - | - | - | - | T4-Lysozyme | - |
K-8794
|
small-molecule | Antagonist | endothelin-2, endothelin-3, endothelin-1 | peptide | No | No | Shihoya W, Nishizawa T, Yamashita K, Inoue A, Hirata K, Kadji FMN, Okuta A, Tani K, Aoki J, Fujiyoshi Y, Doi T, Nureki O | 10.1038/NSMB.3450 | 2017-08-16 | Yes | |
| Q08BG4 | LPA6 | Lysophospholipid (LPA) | A | Zebrafish | X-ray | 5XSZ | 5XSZ_refined | 3.2 | A | Active | 56 | 78 | - | - | - | - | T4-Lysozyme | - |
Apo (no ligand)
|
none | Apo (no ligand) | - | - | No | No | Taniguchi R, Inoue A, Sayama M, Uwamizu A, Yamashita K, Hirata K, Yoshida M, Tanaka Y, Kato HE, Nakada-Nakura Y, Otani Y, Nishizawa T, Doi T, Ohwada T, Ishitani R, Aoki J, Nureki O | 10.1038/NATURE23448 | 2017-08-16 | Yes | |
| OPSD | Rhodopsin | Opsins | A | Human | X-ray | 5W0P | 5W0P_refined | 3.0 | D | Active | 100 | 93 | Visual | S-arrestin | - | 90 | T4-Lysozyme | - |
Apo (no ligand)
|
none | Apo (no ligand) | - | - | No | No | Zhou XE, He Y, de Waal PW, Gao X, Kang Y, Van Eps N, Yin Y, Pal K, Goswami D, White TA, Barty A, Latorraca NR, Chapman HN, Hubbell WL, Dror RO, Stevens RC, Cherezov V, Gurevich VV, Griffin PR, Ernst OP, Melcher K, Xu HE | 10.1016/J.CELL.2017.07.002 | 2017-08-09 | Yes | |
| 5HT2B | 5-HT2B | 5-Hydroxytryptamine | A | Human | X-ray | 5TUD | 5TUD_refined | 3.0 | D | Active | 86 | 58 | - | - | - | - | BRIL | Antibody |
ergotamine
|
small-molecule | Agonist | 5-hydroxytryptamine | small-molecule | No | No | Ishchenko A, Wacker D, Kapoor M, Zhang A, Han GW, Basu S, Patel N, Messerschmidt M, Weierstall U, Liu W, Katritch V, Roth BL, Stevens RC, Cherezov V | 10.1073/PNAS.1700891114 | 2017-07-26 | Yes | |
| AA1R | A1 | Adenosine | A | Human | X-ray | 5N2S | 5N2S_refined | 3.3 | A | Inactive | 1 | 86 | - | - | - | - | BRIL | - |
PSB36
|
small-molecule | Agonist | adenosine | small-molecule | No | No | Cheng RKY, Segala E, Robertson N, Deflorian F, Dore AS, Errey JC, Fiez-Vandal C, Marshall FH, Cooke RM | 10.1016/j.str.2017.06.012 | 2017-07-26 | Yes | |
| AA2AR | A2A | Adenosine | A | Human | X-ray | 5MZP | 5MZP_refined | 2.1 | A | Inactive | 1 | 71 | - | - | - | - | BRIL | - |
caffeine
|
small-molecule | Antagonist | adenosine | small-molecule | No | No | Cheng RKY, Segala E, Robertson N, Deflorian F, Dore AS, Errey JC, Fiez-Vandal C, Marshall FH, Cooke RM | 10.1016/j.str.2017.06.012 | 2017-07-26 | Yes | |
| AA2AR | A2A | Adenosine | A | Human | X-ray | 5MZJ | 5MZJ_refined | 2.0 | A | Inactive | 1 | 71 | - | - | - | - | BRIL | - |
theophylline
|
small-molecule | Antagonist | adenosine | small-molecule | No | No | Cheng RKY, Segala E, Robertson N, Deflorian F, Dore AS, Errey JC, Fiez-Vandal C, Marshall FH, Cooke RM | 10.1016/j.str.2017.06.012 | 2017-07-26 | Yes | |
| AA2AR | A2A | Adenosine | A | Human | X-ray | 5N2R | 5N2R_refined | 2.8 | A | Inactive | 1 | 71 | - | - | - | - | BRIL | - |
PSB36
|
small-molecule | Antagonist | adenosine | small-molecule | No | No | Cheng RKY, Segala E, Robertson N, Deflorian F, Dore AS, Errey JC, Fiez-Vandal C, Marshall FH, Cooke RM | 10.1016/j.str.2017.06.012 | 2017-07-26 | Yes | |
| CNR1 | CB1 | Cannabinoid | A | Human | X-ray | 5XRA | 5XRA_refined | 2.8 | A | Active | 91 | 60 | - | - | - | - | Flavodoxin | - |
AM11542
|
small-molecule | Agonist | 2-arachidonoylglycerol, anandamide | small-molecule | No | No | - | - | 2017-07-12 | Yes | |
| CNR1 | CB1 | Cannabinoid | A | Human | X-ray | 5XR8 | 5XR8_refined | 3.0 | A | Active | 91 | 60 | - | - | - | - | Flavodoxin | - |
AM841
|
small-molecule | Agonist | 2-arachidonoylglycerol, anandamide | small-molecule | No | No | Hua T, Vemuri K, Nikas SP, Laprairie RB, Wu Y, Qu L, Pu M, Korde A, Jiang S, Ho JH, Han GW, Ding K, Li X, Liu H, Hanson MA, Zhao S, Bohn LM, Makriyannis A, Stevens RC, Liu ZJ | 10.1038/NATURE23272 | 2017-07-12 | Yes | |
| CCR5 | CCR5 | Chemokine | A | Human | X-ray | 5UIW | - | 2.2 | A | Inactive | 9 | 85 | - | - | - | - | Rubredoxin | - |
5P7-CCL5
|
protein | Antagonist | CCL13, CCL11, CCL8, CCL2, CCL7, CCL4, CCL5, CCL14, CCL3, CCL16 | peptide | No | No | Zheng Y, Han GW, Abagyan R, Wu B, Stevens RC, Cherezov V, Kufareva I, Handel TM | 10.1016/J.IMMUNI.2017.05.002 | 2017-06-28 | Yes | |
| GLP1R | GLP-1 | Glucagon | B1 | Human | X-ray | 5NX2 | - | 3.7 | A | Intermediate | 56 | 84 | - | - | - | - | - | - |
Truncated protein agonist
|
peptide | Agonist | glucagon-like peptide 1-(7-36) amide, glucagon, glucagon-like peptide 1-(7-37) | peptide | No | No | Jazayeri A, Rappas M, Brown AJH, Kean J, Errey JC, Robertson NJ, Fiez-Vandal C, Andrews SP, Congreve M, Bortolato A, Mason JS, Baig AH, Teobald I, Dore AS, Weir M, Cooke RM, Marshall FH | 10.1038/NATURE22800 | 2017-06-14 | Yes | |
| FFAR1 | FFA1 | Free fatty acid | A | Human | X-ray | 5TZR | 5TZR_refined | 2.2 | A | Active | 56 | 91 | - | - | - | - | T4-Lysozyme | - |
MK-8666
|
small-molecule | Allosteric agonist | myristic acid, oleic acid, docosahexaenoic acid, α-linolenic acid | small-molecule | No | No | Lu J, Byrne N, Wang J, Bricogne G, Brown FK, Chobanian HR, Colletti SL, Di Salvo J, Thomas-Fowlkes B, Guo Y, Hall DL, Hadix J, Hastings NB, Hermes JD, Ho T, Howard AD, Josien H, Kornienko M, Lumb KJ, Miller MW, Patel SB, Pio B, Plummer CW, Sherborne BS, Sheth P, Souza S, Tummala S, Vonrhein C, Webb M, Allen SJ, Johnston JM, Weinglass AB, Sharma S, Soisson SM | 10.1038/NSMB.3417 | 2017-06-07 | Yes | |
| FFAR1 | FFA1 | Free fatty acid | A | Human | X-ray | 5TZY | 5TZY_refined | 3.2 | A | Active | 56 | 91 | - | - | - | - | T4-Lysozyme | - |
MK-8666
(2S,3R)-3-Cyclopropyl-3-[(2R)-2-[1-[(1S)-1-[5-fluoro-2-(trifluoromethoxy)phenyl]ethyl]piperidin-4-yl]-3,4-dihydro-2H-chromen-7-yl]-2-methylpropanoic acid |
small-molecule small-molecule |
Agonist PAM |
myristic acid, oleic acid, docosahexaenoic acid, α-linolenic acid | small-molecule | No | No | Lu J, Byrne N, Wang J, Bricogne G, Brown FK, Chobanian HR, Colletti SL, Di Salvo J, Thomas-Fowlkes B, Guo Y, Hall DL, Hadix J, Hastings NB, Hermes JD, Ho T, Howard AD, Josien H, Kornienko M, Lumb KJ, Miller MW, Patel SB, Pio B, Plummer CW, Sherborne BS, Sheth P, Souza S, Tummala S, Vonrhein C, Webb M, Allen SJ, Johnston JM, Weinglass AB, Sharma S, Soisson SM | 10.1038/NSMB.3417 | 2017-06-07 | Yes | |
| AA2AR | A2A | Adenosine | A | Human | X-ray | 5JTB | 5JTB_refined | 2.8 | A | Inactive | 1 | 72 | - | - | - | - | BRIL | - |
ZM-241385
|
small-molecule | Antagonist | adenosine | small-molecule | No | No | Melnikov I, Polovinkin V, Kovalev K, Gushchin I, Shevtsov M, Shevchenko V, Mishin A, Alekseev A, Rodriguez-Valera F, Borshchevskiy V, Cherezov V, Leonard GA, Gordeliy V, Popov A | 10.1126/SCIADV.1602952 | 2017-05-31 | Yes | |
| APJ | apelin | Apelin | A | Human | X-ray | 5VBL | - | 2.6 | B | Inactive | 8 | 79 | - | - | - | - | Rubredoxin | - |
AMG3054
|
peptide | Agonist | apelin-13, apelin-36, apelin-17, Elabela/Toddler-21, Elabela/Toddler-32, Elabela/Toddler-11, apelin receptor early endogenous ligand, [Pyr1]apelin-13 | peptide | No | No | Ma Y, Yue Y, Ma Y, Zhang Q, Zhou Q, Song Y, Shen Y, Li X, Ma X, Li C, Hanson MA, Han GW, Sickmier EA, Swaminath G, Zhao S, Stevens RC, Hu LA, Zhong W, Zhang M, Xu F | 10.1016/J.STR.2017.04.008 | 2017-05-31 | Yes | |
| AA2AR | A2A | Adenosine | A | Human | X-ray | 5UVI | 5UVI_refined | 3.2 | A | Inactive | 1 | 72 | - | - | - | - | BRIL | - |
ZM-241385
|
small-molecule | Antagonist | adenosine | small-molecule | No | No | Martin-Garcia JM, Conrad CE, Nelson G, Stander N, Zatsepin NA, Zook J, Zhu L, Geiger J, Chun E, Kissick D, Hilgart MC, Ogata C, Ishchenko A, Nagaratnam N, Roy-Chowdhury S, Coe J, Subramanian G, Schaffer A, James D, Ketwala G, Venugopalan N, Xu S, Corcoran S, Ferguson D, Weierstall U, Spence JCH, Cherezov V, Fromme P, Fischetti RF, Liu W | 10.1107/S205225251700570X | 2017-05-24 | Yes | |
| G1SGD4 | GLP-1 | Glucagon | B1 | Rabbit | Cryo-EM | 5VAI | - | 4.1 | R | Active | 100 | 84 | Gs | αs | - | 59 | - | - |
CHEMBL410972
|
protein | Agonist | - | - | No | No | Zhang Y, Sun B, Feng D, Hu H, Chu M, Qu Q, Tarrasch JT, Li S, Sun Kobilka T, Kobilka BK, Skiniotis G | 10.1038/NATURE22394 | 2017-05-24 | Yes | |
| GLP1R | GLP-1 | Glucagon | B1 | Human | X-ray | 5VEW | 5VEW_refined | 2.7 | A | Inactive | 0 | 57 | - | - | - | - | T4-Lysozyme | - |
PF-06372222
|
small-molecule | NAM | glucagon-like peptide 1-(7-36) amide, glucagon, glucagon-like peptide 1-(7-37) | peptide | No | No | Song G, Yang D, Wang Y, de Graaf C, Zhou Q, Jiang S, Liu K, Cai X, Dai A, Lin G, Liu D, Wu F, Wu Y, Zhao S, Ye L, Han GW, Lau J, Wu B, Hanson MA, Liu ZJ, Wang MW, Stevens RC | 10.1038/NATURE22378 | 2017-05-24 | Yes | |
| GLR | glucagon | Glucagon | B1 | Human | X-ray | 5XF1 | 5XF1_refined | 3.2 | B | Inactive | 0 | 81 | - | - | - | - | T4-Lysozyme | Antibody |
NNC0640
|
small-molecule | NAM | glucagon | peptide | No | No | - | - | 2017-05-24 | Yes | |
| GLR | glucagon | Glucagon | B1 | Human | X-ray | 5XEZ | 5XEZ_refined | 3.0 | B | Inactive | 0 | 82 | - | - | - | - | T4-Lysozyme | Antibody |
NNC0640
|
small-molecule | NAM | glucagon | peptide | No | No | Zhang H, Qiao A, Yang D, Yang L, Dai A, de Graaf C, Reedtz-Runge S, Dharmarajan V, Zhang H, Han GW, Grant TD, Sierra RG, Weierstall U, Nelson G, Liu W, Wu Y, Ma L, Cai X, Lin G, Wu X, Geng Z, Dong Y, Song G, Griffin PR, Lau J, Cherezov V, Yang H, Hanson MA, Stevens RC, Zhao Q, Jiang H, Wang MW, Wu B | 10.1038/NATURE22363 | 2017-05-24 | Yes | |
| SMO | SMO | Frizzled | F | Human | X-ray | 5V57 | 5V57_refined | 3.0 | A | Inactive | 0 | 62 | - | - | - | - | Flavodoxin | - |
N-methyl-N-[1-[4-(2-methylpyrazol-3-yl)phthalazin-1-yl]piperidin-4-yl]-4-nitro-2-(trifluoromethyl)benzamide
|
small-molecule | Antagonist | - | - | No | No | Zhang X, Zhao F, Wu Y, Yang J, Han GW, Zhao S, Ishchenko A, Ye L, Lin X, Ding K, Dharmarajan V, Griffin PR, Gati C, Nelson G, Hunter MS, Hanson MA, Cherezov V, Stevens RC, Tan W, Tao H, Xu F | 10.1038/NCOMMS15383 | 2017-05-24 | Yes | |
| SMO | SMO | Frizzled | F | Human | X-ray | 5V56 | 5V56_refined | 2.9 | B | Inactive | 0 | 61 | - | - | - | - | Flavodoxin | - |
N-methyl-N-[1-[4-(2-methylpyrazol-3-yl)phthalazin-1-yl]piperidin-4-yl]-4-nitro-2-(trifluoromethyl)benzamide
|
small-molecule | Antagonist | - | - | No | No | Zhang X, Zhao F, Wu Y, Yang J, Han GW, Zhao S, Ishchenko A, Ye L, Lin X, Ding K, Dharmarajan V, Griffin PR, Gati C, Nelson G, Hunter MS, Hanson MA, Cherezov V, Stevens RC, Tan W, Tao H, Xu F | 10.1038/NCOMMS15383 | 2017-05-24 | Yes | |
| GLP1R | GLP-1 | Glucagon | B1 | Human | X-ray | 5VEX | 5VEX_refined | 3.0 | B | Inactive | 0 | 57 | - | - | - | - | T4-Lysozyme | - |
NNC0640
|
small-molecule | NAM | glucagon-like peptide 1-(7-36) amide, glucagon, glucagon-like peptide 1-(7-37) | peptide | No | No | Song G, Yang D, Wang Y, de Graaf C, Zhou Q, Jiang S, Liu K, Cai X, Dai A, Lin G, Liu D, Wu F, Wu Y, Zhao S, Ye L, Han GW, Lau J, Wu B, Hanson MA, Liu ZJ, Wang MW, Stevens RC | 10.1038/NATURE22378 | 2017-05-17 | Yes | |
| CALCR | CT | Calcitonin | B1 | Human | Cryo-EM | 5UZ7 | - | 4.1 | R | Active | 100 | 56 | Gs | αs | - | 47 | - | - |
calcitonin (salmon synthetic)
|
small-molecule | Agonist | adrenomedullin, calcitonin, β-CGRP, adrenomedullin 2/intermedin, α-CGRP, amylin | peptide | No | No | Liang YL, Khoshouei M, Radjainia M, Zhang Y, Glukhova A, Tarrasch J, Thal DM, Furness SGB, Christopoulos G, Coudrat T, Danev R, Baumeister W, Miller LJ, Christopoulos A, Kobilka BK, Wootten D, Skiniotis G, Sexton PM | 10.1038/NATURE22327 | 2017-05-03 | Yes | |
| PAR2 | PAR2 | Proteinase-activated | A | Human | X-ray | 5NDZ | 5NDZ_refined | 3.6 | A | Active | 56 | 74 | - | - | - | - | BRIL | - |
AZ3451
|
small-molecule | Allosteric antagonist | - | - | No | No | - | - | 2017-05-03 | Yes | |
| PAR2 | PAR2 | Proteinase-activated | A | Human | X-ray | 5NDD | 5NDD_refined | 2.8 | A | Active | 56 | 74 | - | - | - | - | BRIL | - |
AZ8838
|
small-molecule | Antagonist | - | - | No | No | Cheng RKY, Fiez-Vandal C, Schlenker O, Edman K, Aggeler B, Brown DG, Brown GA, Cooke RM, Dumelin CE, Dore AS, Geschwindner S, Grebner C, Hermansson NO, Jazayeri A, Johansson P, Leong L, Prihandoko R, Rappas M, Soutter H, Snijder A, Sundstrom L, Tehan B, Thornton P, Troast D, Wiggin G, Zhukov A, Marshall FH, Dekker N | 10.1038/NATURE22309 | 2017-05-03 | Yes | |
| PAR2 | PAR2 | Proteinase-activated | A | Human | X-ray | 5NJ6 | 5NJ6_refined | 4.0 | A | Active | 56 | 74 | - | - | - | - | BRIL | Fab3949 |
Apo (no ligand)
|
none | Apo (no ligand) | - | - | No | No | Cheng RKY, Fiez-Vandal C, Schlenker O, Edman K, Aggeler B, Brown DG, Brown GA, Cooke RM, Dumelin CE, Dore AS, Geschwindner S, Grebner C, Hermansson NO, Jazayeri A, Johansson P, Leong L, Prihandoko R, Rappas M, Soutter H, Snijder A, Sundstrom L, Tehan B, Thornton P, Troast D, Wiggin G, Zhukov A, Marshall FH, Dekker N | 10.1038/NATURE22309 | 2017-05-03 | Yes | |
| AGTR2 | AT2 | Angiotensin | A | Human | X-ray | 5UNH | 5UNH_refined | 2.9 | B | Active | 98 | 75 | - | - | - | - | BRIL | - |
compound 2 [PMID: 28379944]
|
small-molecule | Antagonist | angiotensin III, angiotensin-(1-7), angiotensin II | peptide | No | No | Zhang H, Han GW, Batyuk A, Ishchenko A, White KL, Patel N, Sadybekov A, Zamlynny B, Rudd MT, Hollenstein K, Tolstikova A, White TA, Hunter MS, Weierstall U, Liu W, Babaoglu K, Moore EL, Katz RD, Shipman JM, Garcia-Calvo M, Sharma S, Sheth P, Soisson SM, Stevens RC, Katritch V, Cherezov V | 10.1038/NATURE22035 | 2017-04-05 | Yes | |
| AGTR2 | AT2 | Angiotensin | A | Human | X-ray | 5UNG | 5UNG_refined | 2.8 | B | Active | 98 | 83 | - | - | - | - | BRIL | - |
compound 1 [PMID: 28379944]
|
small-molecule | Antagonist | angiotensin III, angiotensin-(1-7), angiotensin II | peptide | No | No | Zhang H, Han GW, Batyuk A, Ishchenko A, White KL, Patel N, Sadybekov A, Zamlynny B, Rudd MT, Hollenstein K, Tolstikova A, White TA, Hunter MS, Weierstall U, Liu W, Babaoglu K, Moore EL, Katz RD, Shipman JM, Garcia-Calvo M, Sharma S, Sheth P, Soisson SM, Stevens RC, Katritch V, Cherezov V | 10.1038/NATURE22035 | 2017-04-05 | Yes | |
| AGTR2 | AT2 | Angiotensin | A | Human | X-ray | 5UNF | 5UNF_refined | 2.8 | A | Active | 98 | 79 | - | - | - | - | BRIL | - |
compound 1 [PMID: 28379944]
|
small-molecule | Antagonist | angiotensin III, angiotensin-(1-7), angiotensin II | peptide | No | No | Zhang H, Han GW, Batyuk A, Ishchenko A, White KL, Patel N, Sadybekov A, Zamlynny B, Rudd MT, Hollenstein K, Tolstikova A, White TA, Hunter MS, Weierstall U, Liu W, Babaoglu K, Moore EL, Katz RD, Shipman JM, Garcia-Calvo M, Sharma S, Sheth P, Soisson SM, Stevens RC, Katritch V, Cherezov V | 10.1038/NATURE22035 | 2017-04-05 | Yes | |
| OPSD | Rhodopsin | Opsins | A | Bovine | X-ray | 5TE5 | 5TE5_refined | 4.0 | A | Inactive | 24 | 100 | - | - | - | - | - | - |
10,20-Methanoretinal
|
small-molecule | Agonist | - | - | No | No | Gulati S, Jastrzebska B, Banerjee S, Placeres AL, Miszta P, Gao S, Gunderson K, Tochtrop GP, Filipek S, Katayama K, Kiser PD, Mogi M, Stewart PL, Palczewski K | 10.1073/PNAS.1617446114 | 2017-03-15 | Yes | |
| OPSD | Rhodopsin | Opsins | A | Bovine | X-ray | 5TE3 | 5TE3_refined | 2.7 | A | Active | 98 | 94 | - | - | - | - | - | - |
B-Octylglucoside
|
small-molecule | unknown | - | - | No | No | Gulati S, Jastrzebska B, Banerjee S, Placeres AL, Miszta P, Gao S, Gunderson K, Tochtrop GP, Filipek S, Katayama K, Kiser PD, Mogi M, Stewart PL, Palczewski K | 10.1073/PNAS.1617446114 | 2017-03-15 | Yes | |
| AA1R | A1 | Adenosine | A | Human | X-ray | 5UEN | 5UEN_refined | 3.2 | B | Inactive | 1 | 91 | - | - | - | - | BRIL | - |
DU172
|
small-molecule | Antagonist | adenosine | small-molecule | No | No | Glukhova A, Thal DM, Nguyen AT, Vecchio EA, Jorg M, Scammells PJ, May LT, Sexton PM, Christopoulos A | 10.1016/j.cell.2017.01.042 | 2017-03-01 | Yes | |
| AA2AR | A2A | Adenosine | A | Human | X-ray | 5UIG | 5UIG_refined | 3.5 | A | Inactive | 18 | 70 | - | - | - | - | BRIL | - |
5-Amino-N-[(2-Methoxyphenyl)methyl]-2-(3-Methylphenyl)-2h-1,2,3-Triazole-4-Carboximidamide
|
small-molecule | Antagonist | adenosine | small-molecule | No | No | Sun B, Bachhawat P, Chu ML, Wood M, Ceska T, Sands ZA, Mercier J, Lebon F, Kobilka TS, Kobilka BK | 10.1073/PNAS.1621423114 | 2017-02-08 | Yes | |
| 5HT2B | 5-HT2B | 5-Hydroxytryptamine | A | Human | X-ray | 5TVN | 5TVN_refined | 2.9 | A | Intermediate | 55 | 61 | - | - | - | - | BRIL | - |
Lysergide
|
small-molecule | Agonist | 5-hydroxytryptamine | small-molecule | No | No | Wacker D, Wang S, McCorvy JD, Betz RM, Venkatakrishnan AJ, Levit A, Lansu K, Schools ZL, Che T, Nichols DE, Shoichet BK, Dror RO, Roth BL | 10.1016/J.CELL.2016.12.033 | 2017-02-01 | Yes | |
| NTR1 | NTS1 | Neurotensin | A | Rat | X-ray | 5T04 | 5T04_refined | 3.3 | A | Active | 83 | 69 | - | - | - | - | T4-Lysozyme | - |
neurotensin
|
peptide | Agonist | neurotensin, neuromedin N | peptide | No | No | Krumm BE, Lee S, Bhattacharya S, Botos I, White CF, Du H, Vaidehi N, Grisshammer R | 10.1038/SREP38564 | 2016-12-21 | Yes | |
| CCR2 | CCR2 | Chemokine | A | Human | X-ray | 5T1A | 5T1A_refined | 2.8 | A | Inactive | 9 | 76 | - | - | - | - | T4-Lysozyme | - |
CCR2-RA-[R]
BMS-681 |
small-molecule small-molecule |
Allosteric antagonist Antagonist |
CCL13, CCL11, CCL26, CCL8, CCL2, CCL7, CCL24, CCL16 | peptide | No | No | Zheng Y, Qin L, Zacarias NV, de Vries H, Han GW, Gustavsson M, Dabros M, Zhao C, Cherney RJ, Carter P, Stamos D, Abagyan R, Cherezov V, Stevens RC, IJzerman AP, Heitman LH, Tebben A, Kufareva I, Handel TM | 10.1038/NATURE20605 | 2016-12-14 | Yes | |
| CCR9 | CCR9 | Chemokine | A | Human | X-ray | 5LWE | - | 2.8 | B | Inactive | 47 | 67 | - | - | - | - | - | - |
vercirnon
|
small-molecule | Allosteric antagonist | CCL25 | peptide | No | No | Oswald C, Rappas M, Kean J, Dore AS, Errey JC, Bennett K, Deflorian F, Christopher JA, Jazayeri A, Mason JS, Congreve M, Cooke RM, Marshall FH | 10.1038/NATURE20606 | 2016-12-07 | Yes | |
| CNR1 | CB1 | Cannabinoid | A | Human | X-ray | 5U09 | 5U09_refined | 2.6 | A | Inactive | 7 | 60 | - | - | - | - | Glycogen synthase | - |
taranabant
|
small-molecule | Inverse agonist | 2-arachidonoylglycerol, anandamide | small-molecule | No | No | Shao Z, Yin J, Chapman K, Grzemska M, Clark L, Wang J, Rosenbaum DM | 10.1038/NATURE20613 | 2016-12-07 | Yes | |
| CNR1 | CB1 | Cannabinoid | A | Human | X-ray | 5TGZ | 5TGZ_refined | 2.8 | A | Inactive | 7 | 61 | - | - | - | - | Flavodoxin | - |
AM6538
|
small-molecule | Antagonist | 2-arachidonoylglycerol, anandamide | small-molecule | No | No | Hua T, Vemuri K, Pu M, Qu L, Han GW, Wu Y, Zhao S, Shui W, Li S, Korde A, Laprairie RB, Stahl EL, Ho JH, Zvonok N, Zhou H, Kufareva I, Wu B, Zhao Q, Hanson MA, Bohn LM, Makriyannis A, Stevens RC, Liu ZJ | 10.1016/J.CELL.2016.10.004 | 2016-11-02 | Yes | |
| AA2AR | A2A | Adenosine | A | Human | X-ray | 5K2A | 5K2A_refined | 2.5 | A | Inactive | 1 | 72 | - | - | - | - | BRIL | - |
ZM-241385
|
small-molecule | Antagonist | adenosine | small-molecule | No | No | Batyuk A, Galli L, Ishchenko A, Han GW, Gati C, Popov PA, Lee MY, Stauch B, White TA, Barty A, Aquila A, Hunter MS, Liang M, Boutet S, Pu M, Liu ZJ, Nelson G, James D, Li C, Zhao Y, Spence JC, Liu W, Fromme P, Katritch V, Weierstall U, Stevens RC, Cherezov V | 10.1126/SCIADV.1600292 | 2016-09-21 | Yes | |
| AA2AR | A2A | Adenosine | A | Human | X-ray | 5K2D | 5K2D_refined | 1.9 | A | Inactive | 1 | 72 | - | - | - | - | BRIL | - |
ZM-241385
|
small-molecule | Antagonist | adenosine | small-molecule | No | No | Batyuk A, Galli L, Ishchenko A, Han GW, Gati C, Popov PA, Lee MY, Stauch B, White TA, Barty A, Aquila A, Hunter MS, Liang M, Boutet S, Pu M, Liu ZJ, Nelson G, James D, Li C, Zhao Y, Spence JC, Liu W, Fromme P, Katritch V, Weierstall U, Stevens RC, Cherezov V | 10.1126/SCIADV.1600292 | 2016-09-21 | Yes | |
| AA2AR | A2A | Adenosine | A | Human | X-ray | 5K2B | 5K2B_refined | 2.5 | A | Inactive | 1 | 72 | - | - | - | - | BRIL | - |
ZM-241385
|
small-molecule | Antagonist | adenosine | small-molecule | No | No | Batyuk A, Galli L, Ishchenko A, Han GW, Gati C, Popov PA, Lee MY, Stauch B, White TA, Barty A, Aquila A, Hunter MS, Liang M, Boutet S, Pu M, Liu ZJ, Nelson G, James D, Li C, Zhao Y, Spence JC, Liu W, Fromme P, Katritch V, Weierstall U, Stevens RC, Cherezov V | 10.1126/SCIADV.1600292 | 2016-09-21 | Yes | |
| AA2AR | A2A | Adenosine | A | Human | X-ray | 5K2C | 5K2C_refined | 1.9 | A | Inactive | 1 | 72 | - | - | - | - | BRIL | - |
ZM-241385
|
small-molecule | Antagonist | adenosine | small-molecule | No | No | Batyuk A, Galli L, Ishchenko A, Han GW, Gati C, Popov PA, Lee MY, Stauch B, White TA, Barty A, Aquila A, Hunter MS, Liang M, Boutet S, Pu M, Liu ZJ, Nelson G, James D, Li C, Zhao Y, Spence JC, Liu W, Fromme P, Katritch V, Weierstall U, Stevens RC, Cherezov V | 10.1126/SCIADV.1600292 | 2016-09-21 | Yes | |
| EDNRB | ETB | Endothelin | A | Human | X-ray | 5GLI | 5GLI_refined | 2.5 | A | Inactive | 3 | 71 | - | - | - | - | T4-Lysozyme | - |
Apo (no ligand)
|
none | Apo (no ligand) | endothelin-2, endothelin-3, endothelin-1 | peptide | No | No | Shihoya W, Nishizawa T, Okuta A, Tani K, Dohmae N, Fujiyoshi Y, Nureki O, Doi T | 10.1038/nature19319 | 2016-09-07 | Yes | |
| EDNRB | ETB | Endothelin | A | Human | X-ray | 5GLH | 5GLH_refined | 2.8 | A | Inactive | 16 | 66 | - | - | - | - | T4-Lysozyme | - |
ENDOTHELIN
|
protein | Agonist | endothelin-2, endothelin-3, endothelin-1 | peptide | No | No | Shihoya W, Nishizawa T, Okuta A, Tani K, Dohmae N, Fujiyoshi Y, Nureki O, Doi T | 10.1038/nature19319 | 2016-09-07 | Yes | |
| ADRB2 | β2 | Adrenoceptors | A | Human | X-ray | 5D6L | 5D6L_refined | 3.2 | A | Inactive | 0 | 68 | - | - | - | - | T4-Lysozyme | - |
Carazolol
|
small-molecule | Inverse agonist | Zn2+, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline | small-molecule | No | No | Ma P, Weichert D, Aleksandrov LA, Jensen TJ, Riordan JR, Liu X, Kobilka BK, Caffrey M | 10.1038/NPROT.2017.057 | 2016-08-17 | Yes | |
| OPSD | Rhodopsin | Opsins | A | Bovine | X-ray | 5EN0 | 5EN0_refined | 2.8 | A | Active | 100 | 94 | Gi/o | αgust | Only H5 | 3 | - | - |
Retinal (all-trans)
|
small-molecule | Agonist | - | - | No | No | Singhal A, Guo Y, Matkovic M, Schertler G, Deupi X, Yan EC, Standfuss J | 10.15252/EMBR.201642671 | 2016-08-10 | Yes | |
| OPSD | Rhodopsin | Opsins | A | Bovine | X-ray | 5DYS | 5DYS_refined | 2.3 | A | Active | 98 | 94 | - | - | - | - | - | - |
Retinal (all-trans)
|
small-molecule | Agonist | - | - | No | No | - | - | 2016-08-10 | Yes | |
| AA2AR | A2A | Adenosine | A | Human | X-ray | 5G53 | 5G53_refined | 3.4 | A | Active | 100 | 68 | Gs | αs | Engineered G protein | 50 | - | - |
NECA
|
small-molecule | Agonist | adenosine | small-molecule | No | No | Carpenter B, Nehme R, Warne T, Leslie AG, Tate CG | 10.1038/NATURE18966 | 2016-08-03 | Yes | |
| SMO | SMO | Frizzled | F | Human | X-ray | 5L7I | 5L7I_refined | 3.3 | B | Inactive | 4 | 59 | - | - | - | - | BRIL | - |
vismodegib
|
small-molecule | Antagonist | - | - | No | No | Byrne EFX, Sircar R, Miller PS, Hedger G, Luchetti G, Nachtergaele S, Tully MD, Mydock-McGrane L, Covey DF, Rambo RP, Sansom MSP, Newstead S, Rohatgi R, Siebold C | 10.1038/NATURE18934 | 2016-07-20 | Yes | |
| SMO | SMO | Frizzled | F | Human | X-ray | 5L7D | 5L7D_refined | 3.2 | B | Inactive | 4 | 59 | - | - | - | - | BRIL | - |
Apo (no ligand)
|
none | Apo (no ligand) | - | - | No | No | Byrne EFX, Sircar R, Miller PS, Hedger G, Luchetti G, Nachtergaele S, Tully MD, Mydock-McGrane L, Covey DF, Rambo RP, Sansom MSP, Newstead S, Rohatgi R, Siebold C | 10.1038/NATURE18934 | 2016-07-20 | Yes | |
| ADRB2 | β2 | Adrenoceptors | A | Human | X-ray | 5JQH | 5JQH_refined | 3.2 | A | Inactive | 0 | 70 | - | - | - | - | T4-Lysozyme | Nanobody |
Carazolol
|
small-molecule | Inverse agonist | Zn2+, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline | small-molecule | No | No | Staus DP, Strachan RT, Manglik A, Pani B, Kahsai AW, Kim TH, Wingler LM, Ahn S, Chatterjee A, Masoudi A, Kruse AC, Pardon E, Steyaert J, Weis WI, Prosser RS, Kobilka BK, Costa T, Lefkowitz RJ | 10.1038/NATURE18636 | 2016-07-13 | Yes | |
| AA2AR | A2A | Adenosine | A | Human | X-ray | 5IU7 | 5IU7_refined | 1.9 | A | Inactive | 1 | 72 | - | - | - | - | BRIL | - |
2-(Furan-2-yl)-5-N-[2-(4-phenylpiperidin-1-yl)ethyl]-1H-[1,2,4]triazolo[1,5-a][1,3,5]triazin-8-ium-5,7-diamine
|
small-molecule | Antagonist | adenosine | small-molecule | No | No | Segala E, Guo D, Cheng RK, Bortolato A, Deflorian F, Doré AS, Errey JC, Heitman LH, IJzerman AP, Marshall FH, Cooke RM. | 10.1021/acs.jmedchem.6b00653 | 2016-06-29 | Yes | |
| AA2AR | A2A | Adenosine | A | Human | X-ray | 5IUA | 5IUA_refined | 2.2 | A | Inactive | 1 | 72 | - | - | - | - | BRIL | - |
2-(Furan-2-yl)-5-N-[3-(4-phenylpiperazin-1-yl)propyl]-1H-[1,2,4]triazolo[1,5-a][1,3,5]triazin-8-ium-5,7-diamine
|
small-molecule | Antagonist | adenosine | small-molecule | No | No | Segala E, Guo D, Cheng RK, Bortolato A, Deflorian F, Doré AS, Errey JC, Heitman LH, IJzerman AP, Marshall FH, Cooke RM. | 10.1021/acs.jmedchem.6b00653 | 2016-06-29 | Yes | |
| AA2AR | A2A | Adenosine | A | Human | X-ray | 5IUB | 5IUB_refined | 2.1 | A | Inactive | 1 | 71 | - | - | - | - | BRIL | - |
CHEMBL184061
|
small-molecule | Antagonist | adenosine | small-molecule | No | No | Segala E, Guo D, Cheng RK, Bortolato A, Deflorian F, Doré AS, Errey JC, Heitman LH, IJzerman AP, Marshall FH, Cooke RM. | 10.1021/acs.jmedchem.6b00653 | 2016-06-29 | Yes | |
| AA2AR | A2A | Adenosine | A | Human | X-ray | 5IU8 | 5IU8_refined | 2.0 | A | Inactive | 1 | 71 | - | - | - | - | BRIL | - |
CHEMBL3934661
|
small-molecule | Antagonist | adenosine | small-molecule | No | No | Segala E, Guo D, Cheng RK, Bortolato A, Deflorian F, Doré AS, Errey JC, Heitman LH, IJzerman AP, Marshall FH, Cooke RM. | 10.1021/acs.jmedchem.6b00653 | 2016-06-29 | Yes | |
| AA2AR | A2A | Adenosine | A | Human | X-ray | 5IU4 | 5IU4_refined | 1.7 | A | Inactive | 1 | 71 | - | - | - | - | BRIL | - |
ZM-241385
|
small-molecule | Antagonist | adenosine | small-molecule | No | No | Segala E, Guo D, Cheng RK, Bortolato A, Deflorian F, Doré AS, Errey JC, Heitman LH, IJzerman AP, Marshall FH, Cooke RM. | 10.1021/acs.jmedchem.6b00653 | 2016-06-29 | Yes | |
| CRFR1 | CRF1 | Corticotropin-releasing factor | B1 | Human | X-ray | 4Z9G | - | 3.2 | A | Inactive | 16 | 63 | - | - | - | - | T4-Lysozyme | - |
CP 376,395
|
small-molecule | Antagonist | urocortin 1, urocortin 2, corticotrophin-releasing hormone | peptide | No | No | Dore AS, Bortolato A, Hollenstein K, Cheng RKY, Read RJ, Marshall FH | 10.2174/1874467210666170110114727 | 2016-06-29 | Yes | |
| GLR | glucagon | Glucagon | B1 | Human | X-ray | 5EE7 | 5EE7_refined | 2.5 | A | Inactive | 0 | 54 | - | - | - | - | T4-Lysozyme | - |
Octaethylene glycol monoethyl ether
MK-0893 |
small-molecule small-molecule |
Antagonist NAM |
glucagon | peptide | No | No | Jazayeri A, Dore AS, Lamb D, Krishnamurthy H, Southall SM, Baig AH, Bortolato A, Koglin M, Robertson NJ, Errey JC, Andrews SP, Teobald I, Brown AJ, Cooke RM, Weir M, Marshall FH | 10.1038/NATURE17414 | 2016-04-20 | Yes | |
| OPSD | Rhodopsin | Opsins | A | Human | X-ray | 5DGY | 5DGY_refined | 7.7 | A | Active | 100 | 94 | Visual | S-arrestin | - | 86 | T4-Lysozyme | - |
Apo (no ligand)
|
none | Apo (no ligand) | - | - | No | No | Zhou XE, Gao X, Barty A, Kang Y, He Y, Liu W, Ishchenko A, White TA, Yefanov O, Han GW, Xu Q, de Waal PW, Suino-Powell KM, Boutet S, Williams GJ, Wang M, Li D, Caffrey M, Chapman HN, Spence JC, Fromme P, Weierstall U, Stevens RC, Cherezov V, Melcher K, Xu HE | 10.1038/SDATA.2016.21 | 2016-03-23 | Yes | |
| ACM4 | M4 | Acetylcholine (muscarinic) | A | Human | X-ray | 5DSG | 5DSG_refined | 2.6 | B | Inactive | 3 | 60 | - | - | - | - | T4-Lysozyme | - |
tiotropium
|
small-molecule | Antagonist | acetylcholine | small-molecule | No | No | Thal DM, Sun B, Feng D, Nawaratne V, Leach K, Felder CC, Bures MG, Evans DA, Weis WI, Bachhawat P, Kobilka TS, Sexton PM, Kobilka BK, Christopoulos A | 10.1038/NATURE17188 | 2016-03-16 | Yes | |
| ACM1 | M1 | Acetylcholine (muscarinic) | A | Human | X-ray | 5CXV | 5CXV_refined | 2.7 | A | Inactive | 3 | 62 | - | - | - | - | T4-Lysozyme | - |
0HK
|
small-molecule | Antagonist | acetylcholine | small-molecule | No | No | Thal DM, Sun B, Feng D, Nawaratne V, Leach K, Felder CC, Bures MG, Evans DA, Weis WI, Bachhawat P, Kobilka TS, Sexton PM, Kobilka BK, Christopoulos A | 10.1038/NATURE17188 | 2016-03-09 | Yes | |
| OX1R | OX1 | Orexin | A | Human | X-ray | 4ZJ8 | 4ZJ8_refined | 2.8 | A | Inactive | 1 | 72 | - | - | - | - | GlgA glycogen synthase | - |
suvorexant
|
small-molecule | Antagonist | orexin-B, orexin-A | peptide | No | No | Yin J, Babaoglu K, Brautigam CA, Clark L, Shao Z, Scheuermann TH, Harrell CM, Gotter AL, Roecker AJ, Winrow CJ, Renger JJ, Coleman PJ, Rosenbaum DM | 10.1038/NSMB.3183 | 2016-03-09 | Yes | |
| OX1R | OX1 | Orexin | A | Human | X-ray | 4ZJC | 4ZJC_refined | 2.8 | A | Inactive | 1 | 72 | - | - | - | - | GlgA glycogen synthase | - |
SB-674042
|
small-molecule | Antagonist | orexin-B, orexin-A | peptide | No | No | - | - | 2016-03-09 | Yes | |
| ADRB2 | β2 | Adrenoceptors | A | Human | X-ray | 5D5A | 5D5A_refined | 2.5 | A | Inactive | 0 | 68 | - | - | - | - | T4-Lysozyme | - |
Carazolol
|
small-molecule | Inverse agonist | Zn2+, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline | small-molecule | No | No | Huang CY, Olieric V, Ma P, Howe N, Vogeley L, Liu X, Warshamanage R, Weinert T, Panepucci E, Kobilka B, Diederichs K, Wang M, Caffrey M | 10.1107/S2059798315021683 | 2016-01-13 | Yes | |
| ADRB2 | β2 | Adrenoceptors | A | Human | X-ray | 5D5B | 5D5B_refined | 3.8 | A | Inactive | 0 | 68 | - | - | - | - | T4-Lysozyme | - |
Carazolol
|
small-molecule | Inverse agonist | Zn2+, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline | small-molecule | No | No | - | - | 2016-01-13 | Yes | |
| ADRB1 | β1 | Adrenoceptors | A | Wild turkey | X-ray | 5F8U | 5F8U_refined | 3.4 | A | Inactive | 0 | 57 | - | - | - | - | - | - |
(S)-Cyanopindolol
|
small-molecule | Antagonist | - | - | No | No | Leslie AG, Warne T, Tate CG | 10.1038/NSMB.3130 | 2015-12-23 | Yes | |
| OPSD | Rhodopsin | Opsins | A | Bovine | X-ray | 4X1H | 4X1H_refined | 2.3 | A | Active | 100 | 94 | Gi/o | αt1 | Only H5 | 3 | - | - |
B-Nonylglucoside
|
small-molecule | unknown | - | - | No | No | Blankenship E, Vahedi-Faridi A, Lodowski DT | 10.1016/J.STR.2015.09.015 | 2015-11-04 | Yes | |
| OPRX | NOP | Opioid | A | Human | X-ray | 5DHH | 5DHH_refined | 3.0 | A | Inactive | 8 | 76 | - | - | - | - | BRIL | - |
SB 612111
|
small-molecule | Antagonist | nociceptin/orphanin FQ | peptide | No | No | Miller RL, Thompson AA, Trapella C, Guerrini R, Malfacini D, Patel N, Han GW, Cherezov V, Calo G, Katritch V, Stevens RC | 10.1016/J.STR.2015.07.024 | 2015-10-21 | Yes | |
| OPRX | NOP | Opioid | A | Human | X-ray | 5DHG | 5DHG_refined | 3.0 | A | Inactive | 8 | 76 | - | - | - | - | BRIL | - |
CHEMBL1783826
|
small-molecule | Antagonist | nociceptin/orphanin FQ | peptide | No | No | Miller RL, Thompson AA, Trapella C, Guerrini R, Malfacini D, Patel N, Han GW, Cherezov V, Calo G, Katritch V, Stevens RC | 10.1016/J.STR.2015.07.024 | 2015-10-21 | Yes | |
| AGTR1 | AT1 | Angiotensin | A | Human | X-ray | 4ZUD | 4ZUD_refined | 2.8 | A | Inactive | 8 | 75 | - | - | - | - | BRIL | - |
OLMESARTAN
|
small-molecule | Inverse agonist | angiotensin III, angiotensin IV, angiotensin A, angiotensin II | peptide | No | No | Zhang H, Unal H, Desnoyer R, Han GW, Patel N, Katritch V, Karnik SS, Cherezov V, Stevens RC | 10.1074/JBC.M115.689000 | 2015-10-07 | Yes | |
| ADRB1 | β1 | Adrenoceptors | A | Wild turkey | X-ray | 5A8E | 5A8E_refined | 2.4 | A | Inactive | 0 | 59 | - | - | - | - | - | - |
7-methylcyanopindolol
|
small-molecule | Inverse agonist | - | - | No | No | Sato T, Baker J, Warne T, Brown GA, Leslie AG, Congreve M, Tate CG | 10.1124/MOL.115.101030 | 2015-09-30 | Yes | |
| GRM5 | mGlu5 | Metabotropic glutamate | C | Human | X-ray | 5CGC | 5CGC_refined | 3.1 | A | Inactive | - | 20 | - | - | - | - | T4-Lysozyme | - |
CHEMBL3603915
|
small-molecule | NAM | L-glutamic acid | small-molecule | No | No | Christopher JA, Aves SJ, Bennett KA, Doré AS, Errey JC, Jazayeri A, Marshall FH, Okrasa K, Serrano-Vega MJ, Tehan BG, Wiggin GR, Congreve M. | 10.1021/acs.jmedchem.5b00892 | 2015-08-12 | Yes | |
| GRM5 | mGlu5 | Metabotropic glutamate | C | Human | X-ray | 5CGD | 5CGD_refined | 2.6 | A | Inactive | - | 20 | - | - | - | - | T4-Lysozyme | - |
CHEMBL3603923
|
small-molecule | NAM | L-glutamic acid | small-molecule | No | No | Christopher JA, Aves SJ, Bennett KA, Doré AS, Errey JC, Jazayeri A, Marshall FH, Okrasa K, Serrano-Vega MJ, Tehan BG, Wiggin GR, Congreve M. | 10.1021/acs.jmedchem.5b00892 | 2015-08-12 | Yes | |
| OPRM | μ | Opioid | A | Mouse | X-ray | 5C1M | 5C1M_refined | 2.1 | A | Active | 100 | 74 | - | - | - | - | - | Antibody |
BU72
|
small-molecule | Agonist | - | - | No | No | Huang W, Manglik A, Venkatakrishnan AJ, Laeremans T, Feinberg EN, Sanborn AL, Kato HE, Livingston KE, Thorsen TS, Kling RC, Granier S, Gmeiner P, Husbands SM, Traynor JR, Weis WI, Steyaert J, Dror RO, Kobilka BK | 10.1038/NATURE14886 | 2015-08-05 | Yes | |
| NTR1 | NTS1 | Neurotensin | A | Rat | X-ray | 4XEE | 4XEE_refined | 2.9 | A | Active | 83 | 71 | - | - | - | - | T4-Lysozyme | - |
neurotensin
|
peptide | Agonist | neurotensin, neuromedin N | peptide | No | No | Krumm BE, White JF, Shah P, Grisshammer R | 10.1038/NCOMMS8895 | 2015-07-29 | Yes | |
| NTR1 | NTS1 | Neurotensin | A | Rat | X-ray | 4XES | 4XES_refined | 2.6 | A | Active | 83 | 72 | - | - | - | - | T4-Lysozyme | - |
neurotensin
|
peptide | Agonist | neurotensin, neuromedin N | peptide | No | No | Krumm BE, White JF, Shah P, Grisshammer R | 10.1038/NCOMMS8895 | 2015-07-29 | Yes | |
| OPSD | Rhodopsin | Opsins | A | Human | X-ray | 4ZWJ | 4ZWJ_refined | 3.3 | A | Active | 100 | 94 | Visual | S-arrestin | - | 86 | T4-Lysozyme | - |
Apo (no ligand)
|
none | Apo (no ligand) | - | - | No | No | Kang Y, Zhou XE, Gao X, He Y, Liu W, Ishchenko A, Barty A, White TA, Yefanov O, Han GW, Xu Q, de Waal PW, Ke J, Tan MH, Zhang C, Moeller A, West GM, Pascal BD, Van Eps N, Caro LN, Vishnivetskiy SA, Lee RJ, Suino-Powell KM, Gu X, Pal K, Ma J, Zhi X, Boutet S, Williams GJ, Messerschmidt M, Gati C, Zatsepin NA, Wang D, James D, Basu S, Roy-Chowdhury S, Conrad CE, Coe J, Liu H, Lisova S, Kupitz C, Grotjohann I, Fromme R, Jiang Y, Tan M, Yang H, Li J, Wang M, Zheng Z, Li D, Howe N, Zhao Y, Standfuss J, Diederichs K, Dong Y, Potter CS, Carragher B, Caffrey M, Jiang H, Chapman HN, Spence JC, Fromme P, Weierstall U, Ernst OP, Katritch V, Gurevich VV, Griffin PR, Hubbell WL, Stevens RC, Cherezov V, Melcher K, Xu HE | 10.1038/NATURE14656 | 2015-07-29 | Yes | |
| OPSD | Rhodopsin | Opsins | A | Japanese flying squid | X-ray | 4WW3 | 4WW3_refined | 2.8 | A | Inactive | 9 | 78 | - | - | - | - | - | - |
Retinal (all-trans)
|
small-molecule | Agonist | - | - | No | No | Murakami M, Kouyama T | 10.1371/JOURNAL.PONE.0126970 | 2015-06-17 | Yes | |
| LPAR1 | LPA1 | Lysophospholipid (LPA) | A | Human | X-ray | 4Z36 | 4Z36_refined | 2.9 | A | Inactive | 1 | 79 | - | - | - | - | BRIL | - |
ONO-3080573
|
small-molecule | Antagonist | 1-O-Oleoyl-D-glycerol 3-phosphoric acid | small-molecule | No | No | Chrencik JE, Roth CB, Terakado M, Kurata H, Omi R, Kihara Y, Warshaviak D, Nakade S, Asmar-Rovira G, Mileni M, Mizuno H, Griffith MT, Rodgers C, Han GW, Velasquez J, Chun J, Stevens RC, Hanson MA | 10.1016/J.CELL.2015.06.002 | 2015-06-03 | Yes | |
| LPAR1 | LPA1 | Lysophospholipid (LPA) | A | Human | X-ray | 4Z34 | 4Z34_refined | 3.0 | A | Inactive | 1 | 80 | - | - | - | - | BRIL | - |
ONO-9780307
|
small-molecule | Antagonist | 1-O-Oleoyl-D-glycerol 3-phosphoric acid | small-molecule | No | No | Chrencik JE, Roth CB, Terakado M, Kurata H, Omi R, Kihara Y, Warshaviak D, Nakade S, Asmar-Rovira G, Mileni M, Mizuno H, Griffith MT, Rodgers C, Han GW, Velasquez J, Chun J, Stevens RC, Hanson MA | 10.1016/J.CELL.2015.06.002 | 2015-06-03 | Yes | |
| LPAR1 | LPA1 | Lysophospholipid (LPA) | A | Human | X-ray | 4Z35 | 4Z35_refined | 2.9 | A | Inactive | 1 | 80 | - | - | - | - | BRIL | - |
ONO-9910539
|
small-molecule | Antagonist | 1-O-Oleoyl-D-glycerol 3-phosphoric acid | small-molecule | No | No | Chrencik JE, Roth CB, Terakado M, Kurata H, Omi R, Kihara Y, Warshaviak D, Nakade S, Asmar-Rovira G, Mileni M, Mizuno H, Griffith MT, Rodgers C, Han GW, Velasquez J, Chun J, Stevens RC, Hanson MA | 10.1016/J.CELL.2015.06.002 | 2015-06-03 | Yes | |
| AGTR1 | AT1 | Angiotensin | A | Human | X-ray | 4YAY | 4YAY_refined | 2.9 | A | Inactive | 8 | 79 | - | - | - | - | BRIL | - |
ZD-7155
|
small-molecule | Antagonist | angiotensin III, angiotensin IV, angiotensin A, angiotensin II | peptide | No | No | Zhang H, Unal H, Gati C, Han GW, Liu W, Zatsepin NA, James D, Wang D, Nelson G, Weierstall U, Sawaya MR, Xu Q, Messerschmidt M, Williams GJ, Boutet S, Yefanov OM, White TA, Wang C, Ishchenko A, Tirupula KC, Desnoyer R, Coe J, Conrad CE, Fromme P, Stevens RC, Katritch V, Karnik SS, Cherezov V | 10.1016/J.CELL.2015.04.011 | 2015-04-22 | Yes | |
| AA2AR | A2A | Adenosine | A | Human | X-ray | 4UHR | 4UHR_refined | 2.6 | A | Active | 69 | 75 | - | - | - | - | - | - |
CGS 21680
|
small-molecule | Agonist | adenosine | small-molecule | No | No | Lebon G, Edwards PC, Leslie AG, Tate CG | 10.1124/mol.114.097360 | 2015-04-08 | Yes | |
| AA2AR | A2A | Adenosine | A | Human | X-ray | 4UG2 | 4UG2_refined | 2.6 | A | Active | 69 | 71 | - | - | - | - | - | - |
CGS 21680
|
small-molecule | Agonist | adenosine | small-molecule | No | No | Lebon G, Edwards PC, Leslie AG, Tate CG | 10.1124/mol.114.097360 | 2015-04-08 | Yes | |
| P2RY1 | P2Y1 | P2Y | A | Human | X-ray | 4XNV | - | 2.2 | A | Active | 56 | 78 | - | - | - | - | Rubredoxin | - |
BMS compound 16 [PMID:23368907]
|
small-molecule | NAM | ADP, ATP | small-molecule | No | No | Zhang D, Gao ZG, Zhang K, Kiselev E, Crane S, Wang J, Paoletta S, Yi C, Ma L, Zhang W, Han GW, Liu H, Cherezov V, Katritch V, Jiang H, Stevens RC, Jacobson KA, Zhao Q, Wu B | 10.1038/NATURE14287 | 2015-04-01 | Yes | |
| P2RY1 | P2Y1 | P2Y | A | Human | X-ray | 4XNW | 4XNW_refined | 2.7 | A | Active | 56 | 78 | - | - | - | - | Rubredoxin | - |
MRS2500
|
small-molecule | Antagonist | ADP, ATP | small-molecule | No | No | Zhang D, Gao ZG, Zhang K, Kiselev E, Crane S, Wang J, Paoletta S, Yi C, Ma L, Zhang W, Han GW, Liu H, Cherezov V, Katritch V, Jiang H, Stevens RC, Jacobson KA, Zhao Q, Wu B | 10.1038/NATURE14287 | 2015-04-01 | Yes | |
| US28 | US28 | Unclassified | A | strain AD169 | X-ray | 4XT3 | 4XT3_refined | 3.8 | A | Active | 100 | 81 | - | - | - | - | - | - |
CX3CL1
|
peptide | Agonist (partial) | - | - | No | No | - | - | 2015-03-04 | Yes | |
| US28 | US28 | Unclassified | A | strain AD169 | X-ray | 4XT1 | - | 2.9 | A | Active | 100 | 82 | - | - | - | - | - | Nanobody |
CX3CL1
|
peptide | Agonist (partial) | - | - | No | No | Burg JS, Ingram JR, Venkatakrishnan AJ, Jude KM, Dukkipati A, Feinberg EN, Angelini A, Waghray D, Dror RO, Ploegh HL, Garcia KC | 10.1126/SCIENCE.AAA5026 | 2015-03-04 | Yes | |
| CXCR4 | CXCR4 | Chemokine | A | Human | X-ray | 4RWS | 4RWS_refined | 3.1 | A | Inactive | 8 | 78 | - | - | - | - | T4-Lysozyme | - |
vMIP-II
|
peptide | Antagonist | CXCL12, CXCL12β, CXCL12α, CXCL12φ, CXCL12γ, CXCL12δ, CXCL12ε | peptide | No | No | Qin L, Kufareva I, Holden LG, Wang C, Zheng Y, Zhao C, Fenalti G, Wu H, Han GW, Cherezov V, Abagyan R, Stevens RC, Handel TM | 10.1126/SCIENCE.1261064 | 2015-02-11 | Yes | |
| OPRD | δ | Opioid | A | Human | X-ray | 4RWD | 4RWD_refined | 2.7 | A | Inactive | 8 | 79 | - | - | - | - | BRIL | - |
DIPP-NH2
|
peptide | Antagonist | dynorphin B, dynorphin A-(1-13), dynorphin A-(1-8), β-endorphin, α-neoendorphin, [Met]enkephalin, dynorphin A, [Leu]enkephalin, endomorphin-1 | peptide | No | No | Fenalti G, Zatsepin NA, Betti C, Giguere P, Han GW, Ishchenko A, Liu W, Guillemyn K, Zhang H, James D, Wang D, Weierstall U, Spence JC, Boutet S, Messerschmidt M, Williams GJ, Gati C, Yefanov OM, White TA, Oberthuer D, Metz M, Yoon CH, Barty A, Chapman HN, Basu S, Coe J, Conrad CE, Fromme R, Fromme P, Tourwe D, Schiller PW, Roth BL, Ballet S, Katritch V, Stevens RC, Cherezov V | 10.1038/NSMB.2965 | 2015-01-14 | Yes | |
| OPRD | δ | Opioid | A | Human | X-ray | 4RWA | 4RWA_refined | 3.3 | A | Inactive | 8 | 77 | - | - | - | - | BRIL | - |
DIPP-NH2
|
peptide | Antagonist | dynorphin B, dynorphin A-(1-13), dynorphin A-(1-8), β-endorphin, α-neoendorphin, [Met]enkephalin, dynorphin A, [Leu]enkephalin, endomorphin-1 | peptide | No | No | Fenalti G, Zatsepin NA, Betti C, Giguere P, Han GW, Ishchenko A, Liu W, Guillemyn K, Zhang H, James D, Wang D, Weierstall U, Spence JC, Boutet S, Messerschmidt M, Williams GJ, Gati C, Yefanov OM, White TA, Oberthuer D, Metz M, Yoon CH, Barty A, Chapman HN, Basu S, Coe J, Conrad CE, Fromme R, Fromme P, Tourwe D, Schiller PW, Roth BL, Ballet S, Katritch V, Stevens RC, Cherezov V | 10.1038/NSMB.2965 | 2015-01-14 | Yes | |
| OX2R | OX2 | Orexin | A | Human | X-ray | 4S0V | 4S0V_refined | 2.5 | A | Inactive | 1 | 64 | - | - | - | - | Glycogen synthase | - |
suvorexant
|
small-molecule | Antagonist | orexin-B, orexin-A | peptide | No | No | Yin J, Mobarec JC, Kolb P, Rosenbaum DM | 10.1038/NATURE14035 | 2015-01-14 | Yes | |
| ACM3 | M3 | Acetylcholine (muscarinic) | A | Rat | X-ray | 4U16 | 4U16_refined | 3.7 | B | Inactive | 3 | 47 | - | - | - | - | T4-Lysozyme | - |
N-methyl scopolamine
|
small-molecule | Antagonist | acetylcholine | small-molecule | No | No | Thorsen TS, Matt R, Weis WI, Kobilka BK | 10.1016/J.STR.2014.08.022 | 2014-11-26 | Yes | |
| ACM3 | M3 | Acetylcholine (muscarinic) | A | Rat | X-ray | 4U14 | 4U14_refined | 3.6 | A | Inactive | 3 | 47 | - | - | - | - | T4-Lysozyme | - |
tiotropium
|
small-molecule | Antagonist | acetylcholine | small-molecule | No | No | Thorsen TS, Matt R, Weis WI, Kobilka BK | 10.1016/J.STR.2014.08.022 | 2014-11-26 | Yes | |
| ACM3 | M3 | Acetylcholine (muscarinic) | A | Rat | X-ray | 4U15 | 4U15_refined | 2.8 | B | Inactive | 3 | 47 | - | - | - | - | T4-Lysozyme | - |
tiotropium
|
small-molecule | Antagonist | acetylcholine | small-molecule | No | No | Thorsen TS, Matt R, Weis WI, Kobilka BK | 10.1016/J.STR.2014.08.022 | 2014-11-26 | Yes | |
| OPSD | Rhodopsin | Opsins | A | Bovine | X-ray | 4PXF | 4PXF_refined | 2.8 | A | Active | 100 | 93 | Visual | S-arrestin | Fragment | 2 | - | - |
B-Octylglucoside
|
small-molecule | unknown | - | - | No | No | Szczepek M, Beyriere F, Hofmann KP, Elgeti M, Kazmin R, Rose A, Bartl FJ, von Stetten D, Heck M, Sommer ME, Hildebrand PW, Scheerer P | 10.1038/NCOMMS5801 | 2014-09-17 | Yes | |
| ADRB2 | β2 | Adrenoceptors | A | Human | X-ray | 4QKX | 4QKX_refined | 3.3 | A | Active | 99 | 69 | - | - | - | - | T4-Lysozyme | Nanobody |
Q27453560
|
small-molecule | Agonist | Zn2+, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline | small-molecule | No | No | Weichert D, Kruse AC, Manglik A, Hiller C, Zhang C, Hubner H, Kobilka BK, Gmeiner P | 10.1073/PNAS.1410415111 | 2014-07-23 | Yes | |
| SMO | SMO | Frizzled | F | Human | X-ray | 4QIN | 4QIN_refined | 2.6 | A | Inactive | 10 | 43 | - | - | - | - | BRIL | - |
SAG1.5
|
small-molecule | Agonist | - | - | No | No | Wang C, Wu H, Evron T, Vardy E, Han GW, Huang XP, Hufeisen SJ, Mangano TJ, Urban DJ, Katritch V, Cherezov V, Caron MG, Roth BL, Stevens RC | 10.1038/NCOMMS5355 | 2014-07-23 | Yes | |
| SMO | SMO | Frizzled | F | Human | X-ray | 4QIM | 4QIM_refined | 2.6 | A | Inactive | 7 | 45 | - | - | - | - | BRIL | - |
ANTA XV
|
small-molecule | Antagonist | - | - | No | No | Wang C, Wu H, Evron T, Vardy E, Han GW, Huang XP, Hufeisen SJ, Mangano TJ, Urban DJ, Katritch V, Cherezov V, Caron MG, Roth BL, Stevens RC | 10.1038/NCOMMS5355 | 2014-07-23 | Yes | |
| FFAR1 | FFA1 | Free fatty acid | A | Human | X-ray | 4PHU | 4PHU_refined | 2.3 | A | Active | 56 | 90 | - | - | - | - | T4-Lysozyme | - |
fasiglifam
|
small-molecule | Allosteric agonist | myristic acid, oleic acid, docosahexaenoic acid, α-linolenic acid | small-molecule | No | No | Srivastava A, Yano J, Hirozane Y, Kefala G, Gruswitz F, Snell G, Lane W, Ivetac A, Aertgeerts K, Nguyen J, Jennings A, Okada K | 10.1038/NATURE13494 | 2014-07-16 | Yes | |
| GRM5 | mGlu5 | Metabotropic glutamate | C | Human | X-ray | 4OO9 | 4OO9_refined | 2.6 | A | Inactive | - | 20 | - | - | - | - | T4-Lysozyme | - |
MAVOGLURANT
|
small-molecule | NAM | L-glutamic acid | small-molecule | No | No | Dore AS, Okrasa K, Patel JC, Serrano-Vega M, Bennett K, Cooke RM, Errey JC, Jazayeri A, Khan S, Tehan B, Weir M, Wiggin GR, Marshall FH | 10.1038/NATURE13396 | 2014-07-02 | Yes | |
| P2Y12 | P2Y12 | P2Y | A | Human | X-ray | 4PXZ | 4PXZ_refined | 2.5 | A | Active | 56 | 84 | - | - | - | - | BRIL | - |
2MeSADP
|
small-molecule | Agonist | ADP, ATP | small-molecule | No | No | Zhang J, Zhang K, Gao ZG, Paoletta S, Zhang D, Han GW, Li T, Ma L, Zhang W, Muller CE, Yang H, Jiang H, Cherezov V, Katritch V, Jacobson KA, Stevens RC, Wu B, Zhao Q | 10.1038/NATURE13288 | 2014-04-30 | Yes | |
| P2Y12 | P2Y12 | P2Y | A | Human | X-ray | 4PY0 | 4PY0_refined | 3.1 | A | Active | 56 | 83 | - | - | - | - | BRIL | - |
2MeSATP
|
small-molecule | Agonist (partial) | ADP, ATP | small-molecule | No | No | - | - | 2014-04-30 | Yes | |
| ADRB1 | β1 | Adrenoceptors | A | Wild turkey | X-ray | 4BVN | 4BVN_refined | 2.1 | A | Inactive | 0 | 60 | - | - | - | - | - | - |
(S)-Cyanopindolol
|
small-molecule | Antagonist | - | - | No | No | Miller-Gallacher JL, Nehme R, Warne T, Edwards PC, Schertler GF, Leslie AG, Tate CG | 10.1371/JOURNAL.PONE.0092727 | 2014-04-02 | Yes | |
| P2Y12 | P2Y12 | P2Y | A | Human | X-ray | 4NTJ | 4NTJ_refined | 2.6 | A | Active | 56 | 78 | - | - | - | - | BRIL | - |
AZD1283
|
small-molecule | Antagonist | ADP, ATP | small-molecule | No | No | Zhang K, Zhang J, Gao ZG, Zhang D, Zhu L, Han GW, Moss SM, Paoletta S, Kiselev E, Lu W, Fenalti G, Zhang W, Muller CE, Yang H, Jiang H, Cherezov V, Katritch V, Jacobson KA, Stevens RC, Wu B, Zhao Q | 10.1038/NATURE13083 | 2014-03-26 | Yes | |
| GRM1 | mGlu1 | Metabotropic glutamate | C | Human | X-ray | 4OR2 | 4OR2_refined | 2.8 | B | Inactive | - | 22 | - | - | - | - | BRIL | - |
FITM
|
small-molecule | NAM | L-glutamic acid | small-molecule | No | No | Wu H, Wang C, Gregory KJ, Han GW, Cho HP, Xia Y, Niswender CM, Katritch V, Meiler J, Cherezov V, Conn PJ, Stevens RC | 10.1126/science.1249489 | 2014-03-19 | Yes | |
| SMO | SMO | Frizzled | F | Human | X-ray | 4O9R | 4O9R_refined | 3.2 | A | Inactive | 10 | 42 | - | - | - | - | BRIL | - |
cyclopamine
|
small-molecule | Antagonist | - | - | No | No | Weierstall U, James D, Wang C, White TA, Wang D, Liu W, Spence JC, Bruce Doak R, Nelson G, Fromme P, Fromme R, Grotjohann I, Kupitz C, Zatsepin NA, Liu H, Basu S, Wacker D, Han GW, Katritch V, Boutet S, Messerschmidt M, Williams GJ, Koglin JE, Marvin Seibert M, Klinker M, Gati C, Shoeman RL, Barty A, Chapman HN, Kirian RA, Beyerlein KR, Stevens RC, Li D, Shah ST, Howe N, Caffrey M, Cherezov V | 10.1038/NCOMMS4309 | 2014-03-05 | Yes | |
| NTR1 | NTS1 | Neurotensin | A | Rat | X-ray | 4BWB | - | 3.6 | A | Inactive | 2 | 72 | - | - | - | - | - | - |
neurotensin
|
peptide | Agonist | neurotensin, neuromedin N | peptide | No | No | Egloff P, Hillenbrand M, Klenk C, Batyuk A, Heine P, Balada S, Schlinkmann KM, Scott DJ, Schutz M, Pluckthun A | 10.1073/PNAS.1317903111 | 2014-01-29 | Yes | |
| NTR1 | NTS1 | Neurotensin | A | Rat | X-ray | 3ZEV | 3ZEV_refined | 3.0 | A | Inactive | 2 | 72 | - | - | - | - | - | - |
neurotensin
|
peptide | Agonist | neurotensin, neuromedin N | peptide | No | No | Egloff P, Hillenbrand M, Klenk C, Batyuk A, Heine P, Balada S, Schlinkmann KM, Scott DJ, Schutz M, Pluckthun A | 10.1073/PNAS.1317903111 | 2014-01-29 | Yes | |
| NTR1 | NTS1 | Neurotensin | A | Rat | X-ray | 4BUO | 4BUO_refined | 2.8 | A | Inactive | 2 | 72 | - | - | - | - | - | - |
neurotensin
|
peptide | Agonist | neurotensin, neuromedin N | peptide | No | No | Egloff P, Hillenbrand M, Klenk C, Batyuk A, Heine P, Balada S, Schlinkmann KM, Scott DJ, Schutz M, Pluckthun A | 10.1073/PNAS.1317903111 | 2014-01-29 | Yes | |
| NTR1 | NTS1 | Neurotensin | A | Rat | X-ray | 4BV0 | 4BV0_refined | 3.1 | A | Inactive | 2 | 70 | - | - | - | - | - | - |
neurotensin
|
peptide | Agonist | neurotensin, neuromedin N | peptide | No | No | Egloff P, Hillenbrand M, Klenk C, Batyuk A, Heine P, Balada S, Schlinkmann KM, Scott DJ, Schutz M, Pluckthun A | 10.1073/PNAS.1317903111 | 2014-01-29 | Yes | |
| SMO | SMO | Frizzled | F | Human | X-ray | 4N4W | 4N4W_refined | 2.8 | A | Inactive | 2 | 44 | - | - | - | - | BRIL | - |
SANT-1
|
small-molecule | Antagonist | - | - | No | No | Wang C, Wu H, Evron T, Vardy E, Han GW, Huang XP, Hufeisen SJ, Mangano TJ, Urban DJ, Katritch V, Cherezov V, Caron MG, Roth BL, Stevens RC | 10.1038/NCOMMS5355 | 2014-01-22 | Yes | |
| OPRD | δ | Opioid | A | Human | X-ray | 4N6H | 4N6H_refined | 1.8 | A | Inactive | 8 | 81 | - | - | - | - | BRIL | - |
naltrindole
|
small-molecule | Antagonist | dynorphin B, dynorphin A-(1-13), dynorphin A-(1-8), β-endorphin, α-neoendorphin, [Met]enkephalin, dynorphin A, [Leu]enkephalin, endomorphin-1 | peptide | No | No | Fenalti G, Giguere PM, Katritch V, Huang XP, Thompson AA, Cherezov V, Roth BL, Stevens RC | 10.1038/NATURE12944 | 2013-12-25 | Yes | |
| 5HT2B | 5-HT2B | 5-Hydroxytryptamine | A | Human | X-ray | 4NC3 | 4NC3_refined | 2.8 | A | Intermediate | 55 | 60 | - | - | - | - | BRIL | - |
ergotamine
|
small-molecule | Agonist | 5-hydroxytryptamine | small-molecule | No | No | Liu W, Wacker D, Gati C, Han GW, James D, Wang D, Nelson G, Weierstall U, Katritch V, Barty A, Zatsepin NA, Li D, Messerschmidt M, Boutet S, Williams GJ, Koglin JE, Seibert MM, Wang C, Shah ST, Basu S, Fromme R, Kupitz C, Rendek KN, Grotjohann I, Fromme P, Kirian RA, Beyerlein KR, White TA, Chapman HN, Caffrey M, Spence JC, Stevens RC, Cherezov V | 10.1126/SCIENCE.1244142 | 2013-12-18 | Yes | |
| ACM2 | M2 | Acetylcholine (muscarinic) | A | Human | X-ray | 4MQS | 4MQS_refined | 3.5 | A | Active | 99 | 59 | - | - | - | - | - | Nanobody |
iperoxo
|
small-molecule | Agonist | acetylcholine | small-molecule | No | No | Kruse AC, Ring AM, Manglik A, Hu J, Hu K, Eitel K, Hubner H, Pardon E, Valant C, Sexton PM, Christopoulos A, Felder CC, Gmeiner P, Steyaert J, Weis WI, Garcia KC, Wess J, Kobilka BK | 10.1038/NATURE12735 | 2013-11-27 | Yes | |
| ACM2 | M2 | Acetylcholine (muscarinic) | A | Human | X-ray | 4MQT | 4MQT_refined | 3.7 | A | Active | 99 | 59 | - | - | - | - | - | Nanobody |
iperoxo
LY2119620 |
small-molecule small-molecule |
Agonist PAM |
acetylcholine | small-molecule | No | No | - | - | 2013-11-27 | Yes | |
| OPSD | Rhodopsin | Opsins | A | Bovine | X-ray | 4J4Q | 4J4Q_refined | 2.7 | A | Active | 100 | 94 | Gi/o | αt1 | Only H5 | 3 | - | - |
B-Octylglucoside
|
small-molecule | unknown | - | - | No | No | Park JH, Morizumi T, Li Y, Hong JE, Pai EF, Hofmann KP, Choe HW, Ernst OP | 10.1002/ANIE.201302374 | 2013-10-30 | Yes | |
| ADRB2 | β2 | Adrenoceptors | A | Human | X-ray | 4LDE | 4LDE_refined | 2.8 | A | Active | 99 | 69 | - | - | - | - | T4-Lysozyme | Nanobody |
CHEMBL1615159
|
small-molecule | Agonist | Zn2+, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline | small-molecule | No | No | Ring AM, Manglik A, Kruse AC, Enos MD, Weis WI, Garcia KC, Kobilka BK | 10.1038/NATURE12572 | 2013-09-25 | Yes | |
| ADRB2 | β2 | Adrenoceptors | A | Human | X-ray | 4LDO | 4LDO_refined | 3.2 | A | Active | 99 | 69 | - | - | - | - | T4-Lysozyme | Nanobody |
(-)-adrenaline
|
small-molecule | Agonist | Zn2+, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline | small-molecule | No | No | Ring AM, Manglik A, Kruse AC, Enos MD, Weis WI, Garcia KC, Kobilka BK | 10.1038/NATURE12572 | 2013-09-25 | Yes | |
| ADRB2 | β2 | Adrenoceptors | A | Human | X-ray | 4LDL | 4LDL_refined | 3.1 | A | Active | 99 | 69 | - | - | - | - | T4-Lysozyme | Nanobody |
hydroxybenzylisoproterenol
|
small-molecule | Agonist | Zn2+, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline | small-molecule | No | No | Ring AM, Manglik A, Kruse AC, Enos MD, Weis WI, Garcia KC, Kobilka BK | 10.1038/NATURE12572 | 2013-09-25 | Yes | |
| CCR5 | CCR5 | Chemokine | A | Human | X-ray | 4MBS | 4MBS_refined | 2.7 | A | Inactive | 9 | 83 | - | - | - | - | Rubredoxin | - |
maraviroc
|
small-molecule | Antagonist | CCL13, CCL11, CCL8, CCL2, CCL7, CCL4, CCL5, CCL14, CCL3, CCL16 | peptide | No | No | Tan Q, Zhu Y, Li J, Chen Z, Han GW, Kufareva I, Li T, Ma L, Fenalti G, Li J, Zhang W, Xie X, Yang H, Jiang H, Cherezov V, Liu H, Stevens RC, Zhao Q, Wu B | 10.1126/SCIENCE.1241475 | 2013-09-11 | Yes | |
| GLR | glucagon | Glucagon | B1 | Human | X-ray | 4L6R | 4L6R_refined | 3.3 | A | Inactive | 6 | 61 | - | - | - | - | BRIL | - |
Glucagon model
|
peptide | Agonist | glucagon | peptide | No | No | Siu FY, He M, de Graaf C, Han GW, Yang D, Zhang Z, Zhou C, Xu Q, Wacker D, Joseph JS, Liu W, Lau J, Cherezov V, Katritch V, Wang MW, Stevens RC | 10.1038/nature12393 | 2013-07-24 | Yes | |
| CRFR1 | CRF1 | Corticotropin-releasing factor | B1 | Human | X-ray | 4K5Y | - | 3.0 | C | Inactive | 16 | 60 | - | - | - | - | T4-Lysozyme | - |
CP 376,395
|
small-molecule | Antagonist | urocortin 1, urocortin 2, corticotrophin-releasing hormone | peptide | No | No | Hollenstein K, Kean J, Bortolato A, Cheng RK, Dore AS, Jazayeri A, Cooke RM, Weir M, Marshall FH | 10.1038/NATURE12357 | 2013-07-17 | Yes | |
| OPSD | Rhodopsin | Opsins | A | Bovine | X-ray | 4BEY | 4BEY_refined | 2.9 | A | Active | 100 | 94 | Gi/o | αt1 | Only H5 | 3 | - | - |
Apo (no ligand)
|
none | Apo (no ligand) | - | - | No | No | Singhal A, Ostermaier MK, Vishnivetskiy SA, Panneels V, Homan KT, Tesmer JJ, Veprintsev D, Deupi X, Gurevich VV, Schertler GF, Standfuss J | 10.1038/EMBOR.2013.44 | 2013-05-08 | Yes | |
| OPSD | Rhodopsin | Opsins | A | Bovine | X-ray | 4BEZ | 4BEZ_refined | 3.3 | A | Active | 98 | 94 | - | - | - | - | - | - |
Apo (no ligand)
|
none | Apo (no ligand) | - | - | No | No | Singhal A, Ostermaier MK, Vishnivetskiy SA, Panneels V, Homan KT, Tesmer JJ, Veprintsev D, Deupi X, Gurevich VV, Schertler GF, Standfuss J | 10.1038/EMBOR.2013.44 | 2013-04-24 | Yes | |
| SMO | SMO | Frizzled | F | Human | X-ray | 4JKV | 4JKV_refined | 2.5 | A | Inactive | 0 | 44 | - | - | - | - | BRIL | - |
taladegib
|
small-molecule | Antagonist | - | - | No | No | Wang C, Wu H, Katritch V, Han GW, Huang XP, Liu W, Siu FY, Roth BL, Cherezov V, Stevens RC | 10.1038/NATURE12167 | 2013-04-24 | Yes | |
| ADRB1 | β1 | Adrenoceptors | A | Wild turkey | X-ray | 3ZPQ | 3ZPQ_refined | 2.8 | B | Inactive | 0 | 62 | - | - | - | - | - | - |
CHEMBL200234
|
small-molecule | Antagonist | - | - | No | No | Christopher JA, Brown J, Doré AS, Errey JC, Koglin M, Marshall FH, Myszka DG, Rich RL, Tate CG, Tehan B, Warne T, Congreve M. | 10.1021/jm400140q | 2013-04-03 | Yes | |
| ADRB1 | β1 | Adrenoceptors | A | Wild turkey | X-ray | 3ZPR | 3ZPR_refined | 2.7 | B | Inactive | 0 | 61 | - | - | - | - | - | - |
CHEMBL1559535
|
small-molecule | Antagonist | - | - | No | No | Christopher JA, Brown J, Doré AS, Errey JC, Koglin M, Marshall FH, Myszka DG, Rich RL, Tate CG, Tehan B, Warne T, Congreve M. | 10.1021/jm400140q | 2013-04-03 | Yes | |
| 5HT1B | 5-HT1B | 5-Hydroxytryptamine | A | Human | X-ray | 4IAQ | 4IAQ_refined | 2.8 | A | Inactive | 16 | 70 | - | - | - | - | BRIL | - |
dihydroergotamine
|
small-molecule | Agonist | 5-HT-moduline, tryptamine, 5-hydroxytryptamine | small-molecule | No | No | Wang C, Jiang Y, Ma J, Wu H, Wacker D, Katritch V, Han GW, Liu W, Huang XP, Vardy E, McCorvy JD, Gao X, Zhou XE, Melcher K, Zhang C, Bai F, Yang H, Yang L, Jiang H, Roth BL, Cherezov V, Stevens RC, Xu HE | 10.1126/SCIENCE.1232807 | 2013-03-13 | Yes | |
| 5HT1B | 5-HT1B | 5-Hydroxytryptamine | A | Human | X-ray | 4IAR | 4IAR_refined | 2.7 | A | Inactive | 16 | 70 | - | - | - | - | BRIL | - |
ergotamine
|
small-molecule | Agonist | 5-HT-moduline, tryptamine, 5-hydroxytryptamine | small-molecule | No | No | Wang C, Jiang Y, Ma J, Wu H, Wacker D, Katritch V, Han GW, Liu W, Huang XP, Vardy E, McCorvy JD, Gao X, Zhou XE, Melcher K, Zhang C, Bai F, Yang H, Yang L, Jiang H, Roth BL, Cherezov V, Stevens RC, Xu HE | 10.1126/SCIENCE.1232807 | 2013-03-13 | Yes | |
| 5HT2B | 5-HT2B | 5-Hydroxytryptamine | A | Human | X-ray | 4IB4 | 4IB4_refined | 2.7 | A | Intermediate | 55 | 59 | - | - | - | - | BRIL | - |
ergotamine
|
small-molecule | Agonist | 5-hydroxytryptamine | small-molecule | No | No | Wacker D, Wang C, Katritch V, Han GW, Huang XP, Vardy E, McCorvy JD, Jiang Y, Chu M, Siu FY, Liu W, Xu HE, Cherezov V, Roth BL, Stevens RC | 10.1126/science.1232808 | 2013-03-13 | Yes | |
| ADRB1 | β1 | Adrenoceptors | A | Wild turkey | X-ray | 4GPO | 4GPO_refined | 3.5 | B | Inactive | 0 | 58 | - | - | - | - | - | - |
Apo (no ligand)
|
none | Apo (no ligand) | - | - | No | No | Huang J, Chen S, Zhang JJ, Huang XY | 10.1038/NSMB.2504 | 2013-02-27 | Yes | |
| PAR1 | PAR1 | Proteinase-activated | A | Human | X-ray | 3VW7 | 3VW7_refined | 2.2 | A | Active | 56 | 66 | - | - | - | - | T4-Lysozyme | - |
vorapaxar
|
small-molecule | Antagonist | thrombin | peptide | No | No | Zhang C, Srinivasan Y, Arlow DH, Fung JJ, Palmer D, Zheng Y, Green HF, Pandey A, Dror RO, Shaw DE, Weis WI, Coughlin SR, Kobilka BK | 10.1038/NATURE11701 | 2012-12-12 | Yes | |
| ADRB2 | β2 | Adrenoceptors | A | Human | X-ray | 4GBR | 4GBR_refined | 4.0 | A | Inactive | 0 | 69 | - | - | - | - | T4-Lysozyme | - |
Carazolol
|
small-molecule | Inverse agonist | Zn2+, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline | small-molecule | No | No | Zou Y, Weis WI, Kobilka BK | 10.1371/JOURNAL.PONE.0046039 | 2012-10-24 | Yes | |
| NTR1 | NTS1 | Neurotensin | A | Rat | X-ray | 4GRV | 4GRV_refined | 2.8 | A | Active | 83 | 69 | - | - | - | - | T4-Lysozyme | - |
JMV431
|
peptide | Agonist | neurotensin, neuromedin N | peptide | No | No | White JF, Noinaj N, Shibata Y, Love J, Kloss B, Xu F, Gvozdenovic-Jeremic J, Shah P, Shiloach J, Tate CG, Grisshammer R | 10.1038/NATURE11558 | 2012-10-17 | Yes | |
| AA2AR | A2A | Adenosine | A | Human | X-ray | 4EIY | 4EIY_refined | 1.8 | A | Inactive | 1 | 72 | - | - | - | - | BRIL | - |
ZM-241385
|
small-molecule | Antagonist | adenosine | small-molecule | No | No | Liu W, Chun E, Thompson AA, Chubukov P, Xu F, Katritch V, Han GW, Roth CB, Heitman LH, IJzerman AP, Cherezov V, Stevens RC | 10.1126/SCIENCE.1219218 | 2012-07-25 | Yes | |
| ADRB1 | β1 | Adrenoceptors | A | Wild turkey | X-ray | 4AMI | 4AMI_refined | 3.2 | A | Inactive | 0 | 58 | - | - | - | - | - | - |
Bucindolol
|
small-molecule | Agonist | - | - | No | No | - | - | 2012-05-23 | Yes | |
| ADRB1 | β1 | Adrenoceptors | A | Wild turkey | X-ray | 4AMJ | 4AMJ_refined | 2.3 | B | Inactive | 0 | 62 | - | - | - | - | - | - |
CHEMBL3799125
|
small-molecule | Inverse agonist | - | - | No | No | Warne T, Edwards PC, Leslie AG, Tate CG | 10.1016/J.STR.2012.03.014 | 2012-05-23 | Yes | |
| OPRD | δ | Opioid | A | Mouse | X-ray | 4EJ4 | 4EJ4_refined | 3.4 | A | Inactive | 8 | 76 | - | - | - | - | T4-Lysozyme | - |
naltrindole
|
small-molecule | Antagonist | α-neoendorphin, [Met]enkephalin, [Leu]enkephalin | peptide | No | No | Granier S, Manglik A, Kruse AC, Kobilka TS, Thian FS, Weis WI, Kobilka BK | 10.1038/NATURE11111 | 2012-05-16 | Yes | |
| OPRX | NOP | Opioid | A | Human | X-ray | 4EA3 | 4EA3_refined | 3.0 | A | Inactive | 8 | 75 | - | - | - | - | BRIL | - |
compound 24 [PMID: 16451050]
|
small-molecule | Antagonist | nociceptin/orphanin FQ | peptide | No | No | Thompson AA, Liu W, Chun E, Katritch V, Wu H, Vardy E, Huang XP, Trapella C, Guerrini R, Calo G, Roth BL, Cherezov V, Stevens RC | 10.1038/NATURE11085 | 2012-04-25 | Yes | |
| AA2AR | A2A | Adenosine | A | Human | X-ray | 3UZC | 3UZC_refined | 3.3 | A | Inactive | 1 | 71 | - | - | - | - | - | - |
CHEMBL2024114
|
small-molecule | Antagonist | adenosine | small-molecule | No | No | Congreve M, Andrews SP, Doré AS, Hollenstein K, Hurrell E, Langmead CJ, Mason JS, Ng IW, Tehan B, Zhukov A, Weir M, Marshall FH. | 10.1021/jm201376w | 2012-03-21 | Yes | |
| AA2AR | A2A | Adenosine | A | Human | X-ray | 3UZA | 3UZA_refined | 3.3 | A | Inactive | 1 | 71 | - | - | - | - | - | - |
compound 4g [PMID: 22220592]
|
small-molecule | Antagonist | adenosine | small-molecule | No | No | Congreve M, Andrews SP, Doré AS, Hollenstein K, Hurrell E, Langmead CJ, Mason JS, Ng IW, Tehan B, Zhukov A, Weir M, Marshall FH. | 10.1021/jm201376w | 2012-03-21 | Yes | |
| OPRK | κ | Opioid | A | Human | X-ray | 4DJH | 4DJH_refined | 2.9 | A | Inactive | 8 | 76 | - | - | - | - | T4-Lysozyme | - |
JDTic
|
small-molecule | Antagonist | dynorphin B, dynorphin A-(1-13), dynorphin A-(1-8), β-endorphin, β-neoendorphin, α-neoendorphin, [Met]enkephalin, dynorphin A, [Leu]enkephalin, big dynorphin | peptide | No | No | Wu H, Wacker D, Mileni M, Katritch V, Han GW, Vardy E, Liu W, Thompson AA, Huang XP, Carroll FI, Mascarella SW, Westkaemper RB, Mosier PD, Roth BL, Cherezov V, Stevens RC | 10.1038/NATURE10939 | 2012-03-21 | Yes | |
| OPRM | μ | Opioid | A | Mouse | X-ray | 4DKL | 4DKL_refined | 2.8 | A | Inactive | 8 | 71 | - | - | - | - | T4-Lysozyme | - |
Methyl 4-[[(4R,4aS,7R,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-dihydroxy-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]amino]-4-oxobutanoate
|
small-molecule | Antagonist | - | - | No | No | Manglik A, Kruse AC, Kobilka TS, Thian FS, Mathiesen JM, Sunahara RK, Pardo L, Weis WI, Kobilka BK, Granier S | 10.1038/NATURE10954 | 2012-03-21 | Yes | |
| ACM3 | M3 | Acetylcholine (muscarinic) | A | Rat | X-ray | 4DAJ | - | 3.4 | A | Inactive | 3 | 46 | - | - | - | - | T4-Lysozyme | - |
tiotropium
|
small-molecule | Antagonist | acetylcholine | small-molecule | No | No | Kruse AC, Hu J, Pan AC, Arlow DH, Rosenbaum DM, Rosemond E, Green HF, Liu T, Chae PS, Dror RO, Shaw DE, Weis WI, Wess J, Kobilka BK | 10.1038/NATURE10867 | 2012-02-22 | Yes | |
| S1PR1 | S1P1 | Lysophospholipid (S1P) | A | Human | X-ray | 3V2W | 3V2W_refined | 3.4 | A | Inactive | 1 | 68 | - | - | - | - | T4-Lysozyme | - |
W146
|
small-molecule | Antagonist | dihydrosphingosine 1-phosphate, sphingosylphosphorylcholine, sphingosine 1-phosphate | small-molecule | No | No | Hanson MA, Roth CB, Jo E, Griffith MT, Scott FL, Reinhart G, Desale H, Clemons B, Cahalan SM, Schuerer SC, Sanna MG, Han GW, Kuhn P, Rosen H, Stevens RC | 10.1126/SCIENCE.1215904 | 2012-02-15 | Yes | |
| S1PR1 | S1P1 | Lysophospholipid (S1P) | A | Human | X-ray | 3V2Y | 3V2Y_refined | 2.8 | A | Inactive | 1 | 76 | - | - | - | - | T4-Lysozyme | - |
W146
|
small-molecule | Antagonist | dihydrosphingosine 1-phosphate, sphingosylphosphorylcholine, sphingosine 1-phosphate | small-molecule | No | No | - | - | 2012-02-15 | Yes | |
| AA2AR | A2A | Adenosine | A | Human | X-ray | 3VGA | - | 3.1 | A | Inactive | 1 | 72 | - | - | - | - | - | - |
ZM-241385
|
small-molecule | Antagonist | adenosine | small-molecule | No | No | Hino T, Arakawa T, Iwanari H, Yurugi-Kobayashi T, Ikeda-Suno C, Nakada-Nakura Y, Kusano-Arai O, Weyand S, Shimamura T, Nomura N, Cameron AD, Kobayashi T, Hamakubo T, Iwata S, Murata T | 10.1038/NATURE10750 | 2012-02-01 | Yes | |
| AA2AR | A2A | Adenosine | A | Human | X-ray | 3VG9 | 3VG9_refined | 2.7 | A | Inactive | 1 | 72 | - | - | - | - | - | Antibody fab fragment light chain Antibody fab fragment heavy chain |
ZM-241385
|
small-molecule | Antagonist | adenosine | small-molecule | No | No | Hino T, Arakawa T, Iwanari H, Yurugi-Kobayashi T, Ikeda-Suno C, Nakada-Nakura Y, Kusano-Arai O, Weyand S, Shimamura T, Nomura N, Cameron AD, Kobayashi T, Hamakubo T, Iwata S, Murata T | 10.1038/NATURE10750 | 2012-02-01 | Yes | |
| ACM2 | M2 | Acetylcholine (muscarinic) | A | Human | X-ray | 3UON | 3UON_refined | 3.0 | A | Inactive | 3 | 60 | - | - | - | - | T4-Lysozyme | - |
CHEMBL558910
|
small-molecule | Antagonist | acetylcholine | small-molecule | No | No | Haga K, Kruse AC, Asada H, Yurugi-Kobayashi T, Shiroishi M, Zhang C, Weis WI, Okada T, Kobilka BK, Haga T, Kobayashi T | 10.1038/NATURE10753 | 2012-02-01 | Yes | |
| OPSD | Rhodopsin | Opsins | A | Bovine | X-ray | 4A4M | 4A4M_refined | 3.3 | A | Active | 100 | 94 | Gi/o | αt1 | Only H5 | 3 | - | - |
Retinal (all-trans)
|
small-molecule | Agonist | - | - | No | No | Deupi X, Edwards P, Singhal A, Nickle B, Oprian D, Schertler G, Standfuss J | 10.1073/PNAS.1114089108 | 2012-01-25 | Yes | |
| AA2AR | A2A | Adenosine | A | Human | X-ray | 3PWH | 3PWH_refined | 3.3 | A | Inactive | 1 | 71 | - | - | - | - | - | - |
ZM-241385
|
small-molecule | Antagonist | adenosine | small-molecule | No | No | Dore AS, Robertson N, Errey JC, Ng I, Hollenstein K, Tehan B, Hurrell E, Bennett K, Congreve M, Magnani F, Tate CG, Weir M, Marshall FH | 10.1016/J.STR.2011.06.014 | 2011-09-07 | Yes | |
| AA2AR | A2A | Adenosine | A | Human | X-ray | 3REY | 3REY_refined | 3.3 | A | Inactive | 1 | 71 | - | - | - | - | - | - |
xanthine amine congener
|
small-molecule | Antagonist | adenosine | small-molecule | No | No | Dore AS, Robertson N, Errey JC, Ng I, Hollenstein K, Tehan B, Hurrell E, Bennett K, Congreve M, Magnani F, Tate CG, Weir M, Marshall FH | 10.1016/J.STR.2011.06.014 | 2011-09-07 | Yes | |
| AA2AR | A2A | Adenosine | A | Human | X-ray | 3RFM | 3RFM_refined | 3.6 | A | Inactive | 1 | 71 | - | - | - | - | - | - |
caffeine
|
small-molecule | Antagonist | adenosine | small-molecule | No | No | Dore AS, Robertson N, Errey JC, Ng I, Hollenstein K, Tehan B, Hurrell E, Bennett K, Congreve M, Magnani F, Tate CG, Weir M, Marshall FH | 10.1016/J.STR.2011.06.014 | 2011-09-07 | Yes | |
| OPSD | Rhodopsin | Opsins | A | Japanese flying squid | X-ray | 3AYM | - | 2.8 | B | Inactive | 9 | 77 | - | - | - | - | - | - |
Retinal (all-trans)
|
small-molecule | Agonist | - | - | No | No | Murakami M, Kouyama T | 10.1016/J.JMB.2011.08.044 | 2011-08-17 | Yes | |
| OPSD | Rhodopsin | Opsins | A | Japanese flying squid | X-ray | 3AYN | - | 2.7 | B | Inactive | 9 | 77 | - | - | - | - | - | - |
Retinal (9-cis)
|
small-molecule | Inverse agonist | - | - | No | No | Murakami M, Kouyama T | 10.1016/J.JMB.2011.08.044 | 2011-08-17 | Yes | |
| ADRB2 | β2 | Adrenoceptors | A | Human | X-ray | 3SN6 | - | 3.2 | R | Active | 100 | 69 | Gs | αs | - | 89 | T4-Lysozyme | Antibody |
CHEMBL1615159
|
small-molecule | Agonist | Zn2+, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline | small-molecule | No | No | Rasmussen SG, DeVree BT, Zou Y, Kruse AC, Chung KY, Kobilka TS, Thian FS, Chae PS, Pardon E, Calinski D, Mathiesen JM, Shah ST, Lyons JA, Caffrey M, Gellman SH, Steyaert J, Skiniotis G, Weis WI, Sunahara RK, Kobilka BK | 10.1038/NATURE10361 | 2011-07-20 | Yes | |
| HRH1 | H1 | Histamine | A | Human | X-ray | 3RZE | 3RZE_refined | 3.1 | A | Inactive | 3 | 55 | - | - | - | - | T4-Lysozyme | - |
doxepin
|
small-molecule | Antagonist | histamine | small-molecule | No | No | Shimamura T, Shiroishi M, Weyand S, Tsujimoto H, Winter G, Katritch V, Abagyan R, Cherezov V, Liu W, Han GW, Kobayashi T, Stevens RC, Iwata S | 10.1038/NATURE10236 | 2011-06-15 | Yes | |
| ADRB1 | β1 | Adrenoceptors | A | Wild turkey | X-ray | 2YCY | - | 3.2 | A | Inactive | 0 | 60 | - | - | - | - | - | - |
(S)-Cyanopindolol
|
small-molecule | Antagonist | - | - | No | No | Moukhametzianov R, Warne T, Edwards PC, Serrano-Vega MJ, Leslie AG, Tate CG, Schertler GF | 10.1073/PNAS.1100185108 | 2011-06-08 | Yes | |
| ADRB1 | β1 | Adrenoceptors | A | Wild turkey | X-ray | 2YCW | 2YCW_refined | 3.0 | A | Inactive | 0 | 61 | - | - | - | - | - | - |
Carazolol
|
small-molecule | Antagonist | - | - | No | No | Moukhametzianov R, Warne T, Edwards PC, Serrano-Vega MJ, Leslie AG, Tate CG, Schertler GF | 10.1073/PNAS.1100185108 | 2011-06-01 | Yes | |
| ADRB1 | β1 | Adrenoceptors | A | Wild turkey | X-ray | 2YCX | - | 3.3 | A | Inactive | 0 | 59 | - | - | - | - | - | - |
(S)-Cyanopindolol
|
small-molecule | Antagonist | - | - | No | No | - | - | 2011-06-01 | Yes | |
| ADRB1 | β1 | Adrenoceptors | A | Wild turkey | X-ray | 2YCZ | 2YCZ_refined | 3.7 | B | Inactive | 0 | 60 | - | - | - | - | - | - |
Iodocyanopindolol
|
small-molecule | Antagonist | - | - | No | No | Moukhametzianov R, Warne T, Edwards PC, Serrano-Vega MJ, Leslie AG, Tate CG, Schertler GF | 10.1073/PNAS.1100185108 | 2011-06-01 | Yes | |
| AA2AR | A2A | Adenosine | A | Human | X-ray | 2YDV | 2YDV_refined | 2.6 | A | Active | 69 | 75 | - | - | - | - | - | - |
NECA
|
small-molecule | Agonist | adenosine | small-molecule | No | No | Lebon G, Warne T, Edwards PC, Bennett K, Langmead CJ, Leslie AG, Tate CG | 10.1038/NATURE10136 | 2011-05-18 | Yes | |
| AA2AR | A2A | Adenosine | A | Human | X-ray | 2YDO | 2YDO_refined | 3.0 | A | Active | 69 | 73 | - | - | - | - | - | - |
adenosine
|
small-molecule | Agonist | adenosine | small-molecule | No | No | - | - | 2011-05-18 | Yes | |
| ADRB1 | β1 | Adrenoceptors | A | Wild turkey | X-ray | 2Y01 | - | 2.6 | A | Inactive | 0 | 59 | - | - | - | - | - | - |
Dobutamine
|
small-molecule | Agonist (partial) | - | - | No | No | Warne T, Moukhametzianov R, Baker JG, Nehme R, Edwards PC, Leslie AG, Schertler GF, Tate CG | 10.1038/NATURE09746 | 2011-03-30 | Yes | |
| OPSD | Rhodopsin | Opsins | A | Bovine | X-ray | 2X72 | 2X72_refined | 3.0 | A | Active | 100 | 94 | Gi/o | αt1 | Only H5 | 3 | - | - |
Retinal (all-trans)
|
small-molecule | Agonist | - | - | No | No | Standfuss J, Edwards PC, D'Antona A, Fransen M, Xie G, Oprian DD, Schertler GF | 10.1038/NATURE09795 | 2011-03-16 | Yes | |
| AA2AR | A2A | Adenosine | A | Human | X-ray | 3QAK | 3QAK_refined | 2.7 | A | Active | 69 | 69 | - | - | - | - | T4-Lysozyme | - |
UK-432,097
|
small-molecule | Agonist | adenosine | small-molecule | No | No | Xu F, Wu H, Katritch V, Han GW, Jacobson KA, Gao ZG, Cherezov V, Stevens RC | 10.1126/SCIENCE.1202793 | 2011-03-09 | Yes | |
| OPSD | Rhodopsin | Opsins | A | Bovine | X-ray | 3PQR | 3PQR_refined | 2.9 | A | Active | 100 | 94 | Gi/o | αt1 | Only H5 | 3 | - | - |
Retinal (all-trans)
|
small-molecule | Agonist | - | - | No | No | Choe HW, Kim YJ, Park JH, Morizumi T, Pai EF, Krauss N, Hofmann KP, Scheerer P, Ernst OP | 10.1038/NATURE09789 | 2011-03-09 | Yes | |
| OPSD | Rhodopsin | Opsins | A | Bovine | X-ray | 3PXO | - | 3.0 | A | Active | 98 | 94 | - | - | - | - | - | - |
Retinal (all-trans)
|
small-molecule | Agonist | - | - | No | No | Choe HW, Kim YJ, Park JH, Morizumi T, Pai EF, Krauss N, Hofmann KP, Scheerer P, Ernst OP | 10.1038/NATURE09789 | 2011-03-09 | Yes | |
| ADRB2 | β2 | Adrenoceptors | A | Human | X-ray | 3P0G | 3P0G_refined | 3.5 | A | Active | 99 | 69 | - | - | - | - | T4-Lysozyme | Nanobody |
CHEMBL1615159
|
small-molecule | Agonist | Zn2+, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline | small-molecule | No | No | Rasmussen SG, Choi HJ, Fung JJ, Pardon E, Casarosa P, Chae PS, Devree BT, Rosenbaum DM, Thian FS, Kobilka TS, Schnapp A, Konetzki I, Sunahara RK, Gellman SH, Pautsch A, Steyaert J, Weis WI, Kobilka BK | 10.1038/NATURE09648 | 2011-01-19 | Yes | |
| OPSD | Rhodopsin | Opsins | A | Bovine | X-ray | 3OAX | - | 2.6 | A | Inactive | 24 | 100 | - | - | - | - | - | - |
Retinal (11-cis)
|
small-molecule | Inverse agonist | - | - | No | No | Makino CL, Riley CK, Looney J, Crouch RK, Okada T | 10.1016/J.BPJ.2010.08.003 | 2011-01-19 | Yes | |
| ADRB1 | β1 | Adrenoceptors | A | Wild turkey | X-ray | 2Y00 | 2Y00_refined | 2.5 | B | Inactive | 0 | 62 | - | - | - | - | - | - |
Dobutamine
|
small-molecule | Agonist (partial) | - | - | No | No | Warne T, Moukhametzianov R, Baker JG, Nehme R, Edwards PC, Leslie AG, Schertler GF, Tate CG | 10.1038/NATURE09746 | 2011-01-12 | Yes | |
| ADRB1 | β1 | Adrenoceptors | A | Wild turkey | X-ray | 2Y02 | 2Y02_refined | 2.6 | B | Inactive | 0 | 62 | - | - | - | - | - | - |
CARMOTEROL
|
small-molecule | Agonist | - | - | No | No | - | - | 2011-01-12 | Yes | |
| ADRB1 | β1 | Adrenoceptors | A | Wild turkey | X-ray | 2Y03 | 2Y03_refined | 2.9 | B | Inactive | 0 | 62 | - | - | - | - | - | - |
LEVISOPRENALINE
|
small-molecule | Agonist | - | - | No | No | Warne T, Moukhametzianov R, Baker JG, Nehme R, Edwards PC, Leslie AG, Schertler GF, Tate CG | 10.1038/NATURE09746 | 2011-01-12 | Yes | |
| ADRB1 | β1 | Adrenoceptors | A | Wild turkey | X-ray | 2Y04 | 2Y04_refined | 3.1 | B | Inactive | 0 | 62 | - | - | - | - | - | - |
levosalbutamol
|
small-molecule | Agonist (partial) | - | - | No | No | Warne T, Moukhametzianov R, Baker JG, Nehme R, Edwards PC, Leslie AG, Schertler GF, Tate CG | 10.1038/NATURE09746 | 2011-01-12 | Yes | |
| ADRB2 | β2 | Adrenoceptors | A | Human | X-ray | 3PDS | 3PDS_refined | 3.5 | A | Inactive | 0 | 68 | - | - | - | - | T4-Lysozyme | - |
FAUC50
|
small-molecule | Agonist | Zn2+, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline | small-molecule | No | No | Rosenbaum DM, Zhang C, Lyons JA, Holl R, Aragao D, Arlow DH, Rasmussen SG, Choi HJ, Devree BT, Sunahara RK, Chae PS, Gellman SH, Dror RO, Shaw DE, Weis WI, Caffrey M, Gmeiner P, Kobilka BK | 10.1038/NATURE09665 | 2011-01-12 | Yes | |
| DRD3 | D3 | Dopamine | A | Human | X-ray | 3PBL | 3PBL_refined | 2.9 | A | Inactive | 1 | 68 | - | - | - | - | T4-Lysozyme | - |
eticlopride
|
small-molecule | Antagonist | dopamine | small-molecule | No | No | Chien EY, Liu W, Zhao Q, Katritch V, Han GW, Hanson MA, Shi L, Newman AH, Javitch JA, Cherezov V, Stevens RC | 10.1126/SCIENCE.1197410 | 2010-11-03 | Yes | |
| CXCR4 | CXCR4 | Chemokine | A | Human | X-ray | 3OE6 | 3OE6_refined | 3.2 | A | Inactive | 8 | 77 | - | - | - | - | T4-Lysozyme | - |
isothiourea-1t
|
small-molecule | Antagonist | CXCL12, CXCL12β, CXCL12α, CXCL12φ, CXCL12γ, CXCL12δ, CXCL12ε | peptide | No | No | - | 10.1126/SCIENCE.1194396 | 2010-10-27 | Yes | |
| CXCR4 | CXCR4 | Chemokine | A | Human | X-ray | 3OE0 | - | 2.9 | A | Inactive | 8 | 78 | - | - | - | - | T4-Lysozyme | - |
CVX15
|
peptide | Antagonist | CXCL12, CXCL12β, CXCL12α, CXCL12φ, CXCL12γ, CXCL12δ, CXCL12ε | peptide | No | No | - | - | 2010-10-27 | Yes | |
| CXCR4 | CXCR4 | Chemokine | A | Human | X-ray | 3ODU | 3ODU_refined | 2.5 | A | Inactive | 8 | 83 | - | - | - | - | T4-Lysozyme | - |
isothiourea-1t
|
small-molecule | Antagonist | CXCL12, CXCL12β, CXCL12α, CXCL12φ, CXCL12γ, CXCL12δ, CXCL12ε | peptide | No | No | - | - | 2010-10-27 | Yes | |
| CXCR4 | CXCR4 | Chemokine | A | Human | X-ray | 3OE8 | 3OE8_refined | 3.1 | A | Inactive | 8 | 76 | - | - | - | - | T4-Lysozyme | - |
isothiourea-1t
|
small-molecule | Antagonist | CXCL12, CXCL12β, CXCL12α, CXCL12φ, CXCL12γ, CXCL12δ, CXCL12ε | peptide | No | No | - | - | 2010-10-27 | Yes | |
| CXCR4 | CXCR4 | Chemokine | A | Human | X-ray | 3OE9 | 3OE9_refined | 3.1 | A | Inactive | 8 | 74 | - | - | - | - | T4-Lysozyme | - |
isothiourea-1t
|
small-molecule | Antagonist | CXCL12, CXCL12β, CXCL12α, CXCL12φ, CXCL12γ, CXCL12δ, CXCL12ε | peptide | No | No | - | 10.1126/SCIENCE.1194396 | 2010-10-27 | Yes | |
| ADRB2 | β2 | Adrenoceptors | A | Human | X-ray | 3NY8 | 3NY8_refined | 2.8 | A | Inactive | 0 | 67 | - | - | - | - | T4-Lysozyme | - |
ICI 118551
|
small-molecule | Inverse agonist | Zn2+, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline | small-molecule | No | No | - | 10.1021/JA105108Q | 2010-08-11 | Yes | |
| ADRB2 | β2 | Adrenoceptors | A | Human | X-ray | 3NYA | 3NYA_refined | 3.2 | A | Inactive | 0 | 67 | - | - | - | - | T4-Lysozyme | - |
CHEMBL1160734
|
small-molecule | Antagonist | Zn2+, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline | small-molecule | No | No | - | 10.1021/JA105108Q | 2010-08-11 | Yes | |
| ADRB2 | β2 | Adrenoceptors | A | Human | X-ray | 3NY9 | 3NY9_refined | 2.8 | A | Inactive | 0 | 67 | - | - | - | - | T4-Lysozyme | - |
CHEMBL1233771
|
small-molecule | Inverse agonist | Zn2+, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline | small-molecule | No | No | - | - | 2010-08-11 | Yes | |
| ADRB2 | β2 | Adrenoceptors | A | Human | X-ray | 3KJ6 | - | 3.4 | A | Inactive | 1 | 54 | - | - | - | - | - | Antibody |
Carazolol
|
small-molecule | Inverse agonist | Zn2+, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline | small-molecule | No | No | - | 10.1038/NATURE08650 | 2010-02-16 | Yes | |
| AA2AR | A2A | Adenosine | A | Human | X-ray | 3EML | - | 2.6 | A | Inactive | 1 | 70 | - | - | - | - | T4-Lysozyme | - |
ZM-241385
|
small-molecule | Antagonist | adenosine | small-molecule | No | No | - | 10.1126/SCIENCE.1164772 | 2008-10-14 | Yes | |
| OPSD | Rhodopsin | Opsins | A | Bovine | X-ray | 3DQB | 3DQB_refined | 3.2 | A | Active | 100 | 94 | Gi/o | αt1 | Only H5 | 3 | - | - |
Apo (no ligand)
|
none | Apo (no ligand) | - | - | No | No | - | 10.1038/NATURE07330 | 2008-09-23 | Yes | |
| OPSD | Rhodopsin | Opsins | A | Bovine | X-ray | 3C9L | 3C9L_refined | 2.7 | A | Inactive | 24 | 94 | - | - | - | - | - | - |
Retinal (11-cis)
|
small-molecule | Inverse agonist | - | - | No | No | - | 10.1107/S0907444908017162 | 2008-08-05 | Yes | |
| OPSD | Rhodopsin | Opsins | A | Bovine | X-ray | 3C9M | - | 3.4 | A | Inactive | 24 | 94 | - | - | - | - | - | - |
Retinal (11-cis)
|
small-molecule | Inverse agonist | - | - | No | No | - | 10.1107/S0907444908017162 | 2008-08-05 | Yes | |
| ADRB1 | β1 | Adrenoceptors | A | Wild turkey | X-ray | 2VT4 | - | 2.7 | B | Inactive | 0 | 57 | - | - | - | - | - | - |
(S)-Cyanopindolol
|
small-molecule | Antagonist | - | - | No | No | - | 10.1038/NATURE07101 | 2008-06-24 | Yes | |
| OPSD | Rhodopsin | Opsins | A | Bovine | X-ray | 3CAP | - | 2.9 | A | Active | 98 | 94 | - | - | - | - | - | - |
Apo (no ligand)
|
none | Apo (no ligand) | - | - | No | No | - | 10.1038/NATURE07063 | 2008-06-24 | Yes | |
| ADRB2 | β2 | Adrenoceptors | A | Human | X-ray | 3D4S | 3D4S_refined | 2.8 | A | Inactive | 0 | 67 | - | - | - | - | T4-Lysozyme | - |
timolol
|
small-molecule | Inverse agonist | Zn2+, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline | small-molecule | No | No | - | 10.1016/J.STR.2008.05.001 | 2008-06-17 | Yes | |
| OPSD | Rhodopsin | Opsins | A | Japanese flying squid | X-ray | 2Z73 | 2Z73_refined | 2.5 | A | Inactive | 9 | 78 | - | - | - | - | - | - |
Retinal (11-cis)
|
small-molecule | Inverse agonist | - | - | No | No | - | 10.1038/NATURE06925 | 2008-05-13 | Yes | |
| OPSD | Rhodopsin | Opsins | A | Japanese flying squid | X-ray | 2ZIY | - | 3.7 | A | Inactive | 9 | 83 | - | - | - | - | - | - |
Retinal (11-cis)
|
small-molecule | Inverse agonist | - | - | No | No | - | 10.1074/JBC.C800040200 | 2008-05-06 | Yes | |
| ADRB2 | β2 | Adrenoceptors | A | Human | X-ray | 2R4R | 2R4R_refined | 3.4 | A | Inactive | 1 | 52 | - | - | - | - | - | Antibody |
Carazolol
|
small-molecule | Inverse agonist | Zn2+, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline | small-molecule | No | No | - | - | 2007-11-06 | Yes | |
| ADRB2 | β2 | Adrenoceptors | A | Human | X-ray | 2R4S | 2R4S_refined | 3.4 | A | Inactive | 1 | 52 | - | - | - | - | - | Antibody |
Carazolol
|
small-molecule | Inverse agonist | Zn2+, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline | small-molecule | No | No | - | 10.1038/NATURE06325 | 2007-11-06 | Yes | |
| ADRB2 | β2 | Adrenoceptors | A | Human | X-ray | 2RH1 | - | 2.4 | A | Inactive | 0 | 68 | - | - | - | - | T4-Lysozyme | - |
Carazolol
|
small-molecule | Inverse agonist | Zn2+, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline | small-molecule | No | No | - | 10.1126/SCIENCE.1150577 | 2007-10-30 | Yes | |
| OPSD | Rhodopsin | Opsins | A | Bovine | X-ray | 2PED | - | 3.0 | B | Inactive | 24 | 100 | - | - | - | - | - | - |
Retinal (9-cis)
|
small-molecule | Inverse agonist | - | - | No | No | - | 10.1529/BIOPHYSJ.107.108225 | 2007-10-30 | Yes | |
| OPSD | Rhodopsin | Opsins | A | Bovine | X-ray | 2J4Y | - | 3.4 | B | Inactive | 24 | 94 | - | - | - | - | - | - |
Retinal (11-cis)
|
small-molecule | Inverse agonist | - | - | No | No | - | 10.1016/J.JMB.2007.03.007 | 2007-09-25 | Yes | |
| OPSD | Rhodopsin | Opsins | A | Bovine | X-ray | 2I35 | - | 3.8 | A | Inactive | 24 | 94 | - | - | - | - | - | - |
Retinal (11-cis)
|
small-molecule | Inverse agonist | - | - | No | No | - | - | 2006-10-17 | Yes | |
| OPSD | Rhodopsin | Opsins | A | Bovine | X-ray | 2I37 | 2I37_refined | 4.2 | A | Inactive | 24 | 91 | - | - | - | - | - | - |
Apo (no ligand)
|
none | Apo (no ligand) | - | - | No | No | - | 10.1073/PNAS.0608022103 | 2006-10-17 | Yes | |
| OPSD | Rhodopsin | Opsins | A | Bovine | X-ray | 2I36 | - | 4.1 | A | Inactive | 24 | 94 | - | - | - | - | - | - |
Apo (no ligand)
|
none | Apo (no ligand) | - | - | No | No | - | - | 2006-10-17 | Yes | |
| OPSD | Rhodopsin | Opsins | A | Bovine | X-ray | 2G87 | 2G87_refined | 2.6 | A | Inactive | 24 | 100 | - | - | - | - | - | - |
Retinal (all-trans)
|
small-molecule | Agonist | - | - | No | No | Nakamichi H, Okada T | 10.1002/ANIE.200600595 | 2006-09-02 | Yes | |
| OPSD | Rhodopsin | Opsins | A | Bovine | X-ray | 2HPY | - | 2.8 | B | Inactive | 24 | 100 | - | - | - | - | - | - |
Retinal (all-trans)
|
small-molecule | Agonist | - | - | No | No | Nakamichi H, Okada T | 10.1073/PNAS.0601765103 | 2006-08-22 | Yes | |
| OPSD | Rhodopsin | Opsins | A | Bovine | X-ray | 1U19 | 1U19_refined | 2.2 | A | Inactive | 24 | 100 | - | - | - | - | - | - |
Retinal (11-cis)
|
small-molecule | Inverse agonist | - | - | No | No | Okada T, Sugihara M, Bondar AN, Elstner M, Entel P, Buss V | 10.1016/J.JMB.2004.07.044 | 2004-10-12 | Yes | |
| OPSD | Rhodopsin | Opsins | A | Bovine | X-ray | 1GZM | 1GZM_refined | 2.7 | A | Inactive | 24 | 94 | - | - | - | - | - | - |
Retinal (11-cis)
|
small-molecule | Inverse agonist | - | - | No | No | - | 10.1016/J.JMB.2004.08.090 | 2003-11-20 | Yes | |
| OPSD | Rhodopsin | Opsins | A | Bovine | X-ray | 1L9H | - | 2.6 | A | Inactive | 24 | 98 | - | - | - | - | - | - |
Retinal (11-cis)
|
small-molecule | Inverse agonist | - | - | No | No | - | 10.1073/PNAS.082666399 | 2002-05-15 | Yes | |
| OPSD | Rhodopsin | Opsins | A | Bovine | X-ray | 1HZX | - | 2.8 | A | Inactive | 24 | 98 | - | - | - | - | - | - |
Retinal (11-cis)
|
small-molecule | Inverse agonist | - | - | No | No | - | 10.1021/BI0155091 | 2001-07-04 | Yes | |
| OPSD | Rhodopsin | Opsins | A | Bovine | X-ray | 1F88 | 1F88_refined | 2.8 | A | Inactive | 24 | 97 | - | - | - | - | - | - |
Retinal (11-cis)
|
small-molecule | Inverse agonist | - | - | No | No | Palczewski K, Kumasaka T, Hori T, Behnke CA, Motoshima H, Fox BA, Le Trong I, Teller DC, Okada T, Stenkamp RE, Yamamoto M, Miyano M | 10.1126/SCIENCE.289.5480.739 | 2000-08-04 | Yes | |
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