G13 - 5-HT1D receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 86.6

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.7
PAE mean: 14.7


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar TM3 A 139 3x53 G.H5 N 370 G.H5.19
Hydrophobic TM3 A 139 3x53 G.H5 N 370 G.H5.19
Van-der-waals TM3 A 139 3x53 G.H5 N 370 G.H5.19
Hydrophobic TM6 I 302 6x36 G.H5 M 375 G.H5.24
Van-der-waals TM6 I 302 6x36 G.H5 M 375 G.H5.24
Hydrophobic ICL2 L 144 34x51 G.S3 V 216 G.S3.01
Polar TM6 K 298 6x32 G.H5 Q 377 G.H5.26
Hydrophobic TM6 K 298 6x32 G.H5 Q 377 G.H5.26
Van-der-waals TM6 K 298 6x32 G.H5 Q 377 G.H5.26
Hydrophobic TM5 R 227 5x68 G.H5 L 371 G.H5.20
Ionic TM5 R 227 5x68 G.H5 D 364 G.H5.13
Polar TM5 R 227 5x68 G.H5 D 364 G.H5.13
Hydrophobic TM5 R 227 5x68 G.H5 D 364 G.H5.13
Van-der-waals TM5 R 227 5x68 G.H5 D 364 G.H5.13
Polar ICL3 A 282 - G.H4 E 328 G.H4.13
Hydrophobic ICL3 Y 235 - G.S6 H 344 G.S6.03
Polar ICL3 G 236 - G.H4 R 331 G.H4.16
Hydrophobic TM5 A 224 5x65 G.H5 L 376 G.H5.25
Hydrophobic TM3 I 140 3x54 G.H5 L 374 G.H5.23
Van-der-waals TM3 I 140 3x54 G.H5 L 374 G.H5.23
Hydrophobic ICL3 Y 235 - G.h4s6 P 341 G.h4s6.20
Van-der-waals ICL3 Y 235 - G.h4s6 P 341 G.h4s6.20
Hydrophobic ICL3 F 239 - G.H4 K 324 G.H4.09
Van-der-waals ICL3 F 239 - G.H4 K 324 G.H4.09
Hydrophobic TM3 A 139 3x53 G.H5 L 374 G.H5.23
Hydrophobic ICL2 L 144 34x51 G.H5 K 363 G.H5.12
Van-der-waals ICL2 L 144 34x51 G.H5 K 363 G.H5.12
Hydrophobic ICL3 L 234 - G.S6 H 345 G.S6.04
Van-der-waals ICL3 L 234 - G.S6 H 345 G.S6.04
Hydrophobic TM6 L 303 6x37 G.H5 L 376 G.H5.25
Polar ICL3 L 234 - G.S6 H 344 G.S6.03
Hydrophobic TM6 A 299 6x33 G.H5 L 376 G.H5.25
Hydrophobic ICL2 K 148 34x55 G.S3 V 216 G.S3.01
Van-der-waals ICL2 K 148 34x55 G.S3 V 216 G.S3.01
Hydrophobic TM5 P 232 5x73 G.H5 D 364 G.H5.13
Van-der-waals TM5 P 232 5x73 G.H5 D 364 G.H5.13
Hydrophobic H8 N 360 8x47 G.H5 M 375 G.H5.24
Van-der-waals H8 N 360 8x47 G.H5 M 375 G.H5.24
Hydrophobic TM7 F 359 7x56 G.H5 M 375 G.H5.24
Van-der-waals TM7 F 359 7x56 G.H5 M 375 G.H5.24
Polar ICL2 K 148 34x55 G.s2s3 N 215 G.s2s3.02
Hydrophobic ICL2 K 148 34x55 G.s2s3 N 215 G.s2s3.02
Van-der-waals ICL2 K 148 34x55 G.s2s3 N 215 G.s2s3.02
Hydrophobic ICL2 L 144 34x51 G.H5 F 359 G.H5.08
Van-der-waals ICL2 L 144 34x51 G.H5 F 359 G.H5.08
Hydrophobic TM3 R 136 3x50 G.H5 L 374 G.H5.23
Van-der-waals TM3 R 136 3x50 G.H5 L 374 G.H5.23
Hydrophobic TM5 I 220 5x61 G.H5 L 376 G.H5.25
Van-der-waals TM5 I 220 5x61 G.H5 L 376 G.H5.25
Hydrophobic TM3 I 140 3x54 G.H5 L 371 G.H5.20
Van-der-waals ICL3 K 237 - G.H4 R 320 G.H4.05
Hydrophobic ICL2 A 143 34x50 G.H5 I 366 G.H5.15
Hydrophobic TM3 I 140 3x54 G.H5 L 376 G.H5.25
Van-der-waals TM3 I 140 3x54 G.H5 L 376 G.H5.25
Polar ICL3 G 236 - G.S6 H 344 G.S6.03
Hydrophobic ICL3 G 236 - G.S6 H 344 G.S6.03
Van-der-waals ICL3 G 236 - G.S6 H 344 G.S6.03
Van-der-waals ICL2 A 143 34x50 G.H5 N 370 G.H5.19
Hydrophobic TM5 A 224 5x65 G.H5 L 371 G.H5.20
Hydrophobic ICL3 L 234 - G.H5 D 364 G.H5.13
Hydrophobic ICL3 L 234 - G.S6 Y 343 G.S6.02
Ionic ICL1 R 67 12x48 G.HN D 3 G.HN.03
Polar ICL1 R 67 12x48 G.HN D 3 G.HN.03
Van-der-waals ICL1 R 67 12x48 G.HN D 3 G.HN.03
Hydrophobic ICL3 A 282 - G.H4 K 324 G.H4.09
Hydrophobic TM3 I 140 3x54 G.H5 L 367 G.H5.16
Van-der-waals TM3 I 140 3x54 G.H5 L 367 G.H5.16
Hydrophobic ICL2 L 144 34x51 G.H5 I 366 G.H5.15
Van-der-waals ICL2 L 144 34x51 G.H5 I 366 G.H5.15
Polar ICL2 K 148 34x55 G.hns1 R 47 G.hns1.03
Hydrophobic ICL2 K 148 34x55 G.hns1 R 47 G.hns1.03
Hydrophobic TM5 R 227 5x68 G.H5 L 367 G.H5.16
Hydrophobic ICL3 L 234 - G.H5 D 361 G.H5.10
Van-der-waals ICL3 L 234 - G.H5 D 361 G.H5.10
Ionic H8 E 361 8x48 G.H5 K 372 G.H5.21
Hydrophobic ICL2 A 143 34x50 G.H5 L 367 G.H5.16
Hydrophobic ICL3 L 234 - G.H5 R 360 G.H5.09
Van-der-waals ICL3 L 234 - G.H5 R 360 G.H5.09
Hydrophobic ICL3 R 238 - G.H4 R 331 G.H4.16
Van-der-waals ICL3 R 238 - G.H4 R 331 G.H4.16