Gq - 5-HT1F receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gq/11

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 86.3

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.8
PAE mean: 12.3


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar TM5 Y 212 5x69 G.H5 V 359 G.H5.26
Hydrophobic TM5 Y 212 5x69 G.H5 V 359 G.H5.26
Van-der-waals TM5 Y 212 5x69 G.H5 V 359 G.H5.26
Polar ICL3 K 222 - G.S6 S 326 G.S6.03
Van-der-waals ICL3 K 222 - G.S6 S 326 G.S6.03
Hydrophobic TM3 I 125 3x54 G.H5 L 358 G.H5.25
Hydrophobic ICL2 A 128 34x50 G.H5 I 348 G.H5.15
Hydrophobic ICL2 A 128 34x50 G.H5 L 349 G.H5.16
Ionic TM2 H 56 2x37 G.H5 E 355 G.H5.22
Polar TM2 H 56 2x37 G.H5 E 355 G.H5.22
Hydrophobic TM2 H 56 2x37 G.H5 E 355 G.H5.22
Van-der-waals TM2 H 56 2x37 G.H5 E 355 G.H5.22
Ionic ICL2 R 135 34x57 G.H5 E 355 G.H5.22
Polar ICL2 R 135 34x57 G.H5 E 355 G.H5.22
Hydrophobic TM5 L 211 5x68 G.H5 L 349 G.H5.16
Van-der-waals TM5 L 211 5x68 G.H5 L 349 G.H5.16
Hydrophobic TM5 L 211 5x68 G.H5 D 346 G.H5.13
Van-der-waals TM5 L 211 5x68 G.H5 D 346 G.H5.13
Polar TM5 R 215 5x72 G.S6 Y 325 G.S6.02
Van-der-waals TM5 R 215 5x72 G.S6 Y 325 G.S6.02
Ionic ICL3 K 276 - G.H4 D 315 G.H4.17
Polar ICL3 K 276 - G.H4 D 315 G.H4.17
Hydrophobic ICL2 V 129 34x51 G.H5 F 341 G.H5.08
Polar ICL2 E 130 34x52 G.s2s3 S 198 G.s2s3.02
Hydrophobic ICL2 E 130 34x52 G.s2s3 S 198 G.s2s3.02
Van-der-waals ICL2 E 130 34x52 G.s2s3 S 198 G.s2s3.02
Hydrophobic TM3 A 124 3x53 G.H5 Y 356 G.H5.23
Van-der-waals TM3 A 124 3x53 G.H5 Y 356 G.H5.23
Hydrophobic ICL2 V 129 34x51 G.S1 L 40 G.S1.02
Polar TM6 A 291 6x33 G.H5 L 358 G.H5.25
Hydrophobic TM6 A 291 6x33 G.H5 L 358 G.H5.25
Van-der-waals TM6 A 291 6x33 G.H5 L 358 G.H5.25
Hydrophobic TM5 A 208 5x65 G.H5 L 353 G.H5.20
Hydrophobic TM6 T 294 6x36 G.H5 L 358 G.H5.25
Hydrophobic TM3 R 121 3x50 G.H5 Y 356 G.H5.23
Van-der-waals TM3 R 121 3x50 G.H5 Y 356 G.H5.23
Hydrophobic ICL2 V 129 34x51 G.H5 K 345 G.H5.12
Van-der-waals ICL2 V 129 34x51 G.H5 K 345 G.H5.12
Hydrophobic TM5 I 204 5x61 G.H5 L 358 G.H5.25
Van-der-waals TM5 I 204 5x61 G.H5 L 358 G.H5.25
Hydrophobic TM3 I 125 3x54 G.H5 L 349 G.H5.16
Van-der-waals TM3 I 125 3x54 G.H5 L 349 G.H5.16
Hydrophobic TM5 L 211 5x68 G.H5 Q 350 G.H5.17
Van-der-waals TM5 L 211 5x68 G.H5 Q 350 G.H5.17
Polar ICL2 R 133 34x55 G.s2s3 S 198 G.s2s3.02
Hydrophobic ICL2 V 129 34x51 G.H5 I 348 G.H5.15
Polar ICL1 H 55 12x51 G.hns1 R 37 G.hns1.02
Polar TM3 A 124 3x53 G.H5 N 352 G.H5.19
Hydrophobic TM3 A 124 3x53 G.H5 N 352 G.H5.19
Van-der-waals TM3 A 124 3x53 G.H5 N 352 G.H5.19
Polar TM5 R 219 5x76 G.h4s6 S 320 G.h4s6.11
Hydrophobic TM3 I 125 3x54 G.H5 Y 356 G.H5.23
Polar TM6 T 294 6x36 G.H5 N 357 G.H5.24
Hydrophobic TM6 T 294 6x36 G.H5 N 357 G.H5.24
Van-der-waals TM6 T 294 6x36 G.H5 N 357 G.H5.24
Hydrophobic TM3 I 125 3x54 G.H5 L 353 G.H5.20
Ionic TM5 R 215 5x72 G.H5 D 346 G.H5.13
Polar TM5 R 215 5x72 G.H5 D 346 G.H5.13
Hydrophobic TM5 R 215 5x72 G.H5 D 346 G.H5.13
Van-der-waals TM5 R 215 5x72 G.H5 D 346 G.H5.13
Polar TM7 F 350 7x56 G.H5 N 357 G.H5.24
Hydrophobic TM7 F 350 7x56 G.H5 N 357 G.H5.24
Van-der-waals TM7 F 350 7x56 G.H5 N 357 G.H5.24
Hydrophobic TM6 L 295 6x37 G.H5 L 358 G.H5.25
Van-der-waals TM6 L 295 6x37 G.H5 L 358 G.H5.25
Hydrophobic ICL2 V 129 34x51 G.S3 V 199 G.S3.01
Van-der-waals ICL2 V 129 34x51 G.S3 V 199 G.S3.01
Hydrophobic TM5 L 211 5x68 G.H5 L 353 G.H5.20
Van-der-waals TM5 L 211 5x68 G.H5 L 353 G.H5.20
Polar TM6 K 290 6x32 G.H5 V 359 G.H5.26
Hydrophobic TM6 K 290 6x32 G.H5 V 359 G.H5.26
Van-der-waals TM6 K 290 6x32 G.H5 V 359 G.H5.26
Hydrophobic TM2 A 58 2x39 G.H5 E 355 G.H5.22
Van-der-waals TM2 A 58 2x39 G.H5 E 355 G.H5.22
Hydrophobic TM6 K 290 6x32 G.H5 N 357 G.H5.24
Ionic TM6 R 287 6x29 G.h4s6 D 321 G.h4s6.12
Polar TM6 R 287 6x29 G.h4s6 D 321 G.h4s6.12
Van-der-waals TM6 R 287 6x29 G.h4s6 D 321 G.h4s6.12
Hydrophobic ICL2 R 133 34x55 G.hns1 R 38 G.hns1.03
Hydrophobic TM6 R 287 6x29 G.H5 V 359 G.H5.26
Van-der-waals TM6 R 287 6x29 G.H5 V 359 G.H5.26
Polar TM5 R 215 5x72 G.H5 Q 350 G.H5.17
Hydrophobic TM5 R 215 5x72 G.H5 Q 350 G.H5.17
Van-der-waals TM5 R 215 5x72 G.H5 Q 350 G.H5.17
Hydrophobic TM5 R 215 5x72 G.h4s6 I 323 G.h4s6.20
Van-der-waals TM5 R 215 5x72 G.h4s6 I 323 G.h4s6.20
Polar ICL2 R 135 34x57 G.H5 Y 356 G.H5.23
Hydrophobic ICL2 R 135 34x57 G.H5 Y 356 G.H5.23
Van-der-waals ICL2 R 135 34x57 G.H5 Y 356 G.H5.23
Polar TM5 Y 212 5x69 G.H5 L 358 G.H5.25
Van-der-waals TM5 Y 212 5x69 G.H5 L 358 G.H5.25