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5-HT2A receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 81.6
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.8
iPTM Score: 0.7
PAE mean: 12.7
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
Gβ,
Gγ,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | ICL3 | R | 310 | - | G.H5 | I | 344 | G.H5.16 |
Van-der-waals | ICL3 | R | 310 | - | G.H5 | I | 344 | G.H5.16 |
Hydrophobic | ICL3 | G | 308 | - | G.H5 | V | 334 | G.H5.06 |
Polar | TM6 | K | 320 | 6x32 | G.H5 | Y | 354 | G.H5.26 |
Hydrophobic | TM6 | K | 320 | 6x32 | G.H5 | Y | 354 | G.H5.26 |
Van-der-waals | TM6 | K | 320 | 6x32 | G.H5 | Y | 354 | G.H5.26 |
Polar | TM6 | S | 314 | 6x26 | G.h4s6 | E | 318 | G.h4s6.12 |
Hydrophobic | TM6 | S | 314 | 6x26 | G.h4s6 | E | 318 | G.h4s6.12 |
Van-der-waals | TM6 | S | 314 | 6x26 | G.h4s6 | E | 318 | G.h4s6.12 |
Polar | ICL3 | T | 311 | - | G.h4s6 | E | 318 | G.h4s6.12 |
Hydrophobic | ICL3 | T | 311 | - | G.h4s6 | E | 318 | G.h4s6.12 |
Van-der-waals | ICL3 | T | 311 | - | G.h4s6 | E | 318 | G.h4s6.12 |
Hydrophobic | ICL3 | Y | 306 | - | G.S6 | M | 323 | G.S6.05 |
Van-der-waals | ICL3 | Y | 306 | - | G.S6 | M | 323 | G.S6.05 |
Hydrophobic | C-term | I | 414 | - | G.H3 | L | 250 | G.H3.08 |
Polar | TM3 | A | 176 | 3x53 | G.H5 | N | 347 | G.H5.19 |
Van-der-waals | TM3 | A | 176 | 3x53 | G.H5 | N | 347 | G.H5.19 |
Polar | TM6 | N | 317 | 6x29 | G.h4s6 | E | 318 | G.h4s6.12 |
Polar | TM2 | T | 109 | 2x39 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | TM2 | T | 109 | 2x39 | G.H5 | C | 351 | G.H5.23 |
Polar | TM2 | N | 107 | 2x37 | G.H5 | G | 350 | G.H5.22 |
Van-der-waals | TM2 | N | 107 | 2x37 | G.H5 | G | 350 | G.H5.22 |
Polar | ICL3 | Y | 306 | - | G.H4 | Y | 297 | G.H4.03 |
Hydrophobic | ICL3 | Y | 306 | - | G.H4 | Y | 297 | G.H4.03 |
Hydrophobic | ICL3 | Y | 306 | - | G.H4 | A | 301 | G.H4.07 |
Van-der-waals | ICL3 | Y | 306 | - | G.H4 | A | 301 | G.H4.07 |
Hydrophobic | C-term | Y | 419 | - | G.s4h3 | E | 237 | G.s4h3.10 |
Van-der-waals | C-term | Y | 419 | - | G.s4h3 | E | 237 | G.s4h3.10 |
Polar | C-term | Y | 419 | - | G.s4h3 | T | 241 | G.s4h3.14 |
Hydrophobic | C-term | Y | 419 | - | G.s4h3 | T | 241 | G.s4h3.14 |
Van-der-waals | C-term | Y | 419 | - | G.s4h3 | T | 241 | G.s4h3.14 |
Polar | C-term | Y | 419 | - | G.s4h3 | D | 238 | G.s4h3.11 |
Hydrophobic | C-term | Y | 419 | - | G.s4h3 | D | 238 | G.s4h3.11 |
Van-der-waals | C-term | Y | 419 | - | G.s4h3 | D | 238 | G.s4h3.11 |
Hydrophobic | C-term | L | 417 | - | G.H3 | E | 246 | G.H3.04 |
Polar | ICL2 | P | 180 | 34x50 | G.H5 | N | 347 | G.H5.19 |
Van-der-waals | ICL2 | P | 180 | 34x50 | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | ICL3 | T | 311 | - | G.S6 | Y | 320 | G.S6.02 |
Hydrophobic | C-term | L | 406 | - | G.H3 | F | 259 | G.H3.17 |
Van-der-waals | C-term | L | 406 | - | G.H3 | F | 259 | G.H3.17 |
Polar | TM6 | Q | 313 | 6x25 | G.H5 | Y | 354 | G.H5.26 |
Polar | TM6 | Q | 313 | 6x25 | G.h4s6 | P | 315 | G.h4s6.09 |
Van-der-waals | TM6 | Q | 313 | 6x25 | G.h4s6 | P | 315 | G.h4s6.09 |
Ionic | ICL3 | R | 310 | - | G.H5 | D | 341 | G.H5.13 |
Polar | ICL3 | R | 310 | - | G.H5 | D | 341 | G.H5.13 |
Hydrophobic | ICL3 | R | 310 | - | G.H5 | D | 341 | G.H5.13 |
Van-der-waals | ICL3 | R | 310 | - | G.H5 | D | 341 | G.H5.13 |
Hydrophobic | C-term | I | 414 | - | G.H3 | S | 253 | G.H3.11 |
Van-der-waals | C-term | I | 414 | - | G.H3 | S | 253 | G.H3.11 |
Hydrophobic | TM3 | I | 177 | 3x54 | G.H5 | L | 348 | G.H5.20 |
Van-der-waals | ICL2 | R | 185 | 34x55 | G.S3 | H | 196 | G.S3.02 |
Polar | TM6 | A | 321 | 6x33 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | TM6 | A | 321 | 6x33 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM6 | A | 321 | 6x33 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | TM6 | Q | 313 | 6x25 | G.h4s6 | E | 318 | G.h4s6.12 |
Van-der-waals | TM6 | Q | 313 | 6x25 | G.h4s6 | E | 318 | G.h4s6.12 |
Hydrophobic | ICL2 | I | 181 | 34x51 | G.H5 | I | 343 | G.H5.15 |
Hydrophobic | C-term | L | 410 | - | G.H2 | K | 210 | G.H2.05 |
Hydrophobic | ICL2 | P | 180 | 34x50 | G.H5 | I | 344 | G.H5.16 |
Van-der-waals | ICL2 | P | 180 | 34x50 | G.H5 | I | 344 | G.H5.16 |
Polar | TM6 | S | 314 | 6x26 | G.H5 | D | 341 | G.H5.13 |
Hydrophobic | TM6 | S | 314 | 6x26 | G.H5 | D | 341 | G.H5.13 |
Van-der-waals | TM6 | S | 314 | 6x26 | G.H5 | D | 341 | G.H5.13 |
Polar | ICL2 | R | 185 | 34x55 | G.s2s3 | N | 194 | G.s2s3.02 |
Van-der-waals | ICL2 | R | 185 | 34x55 | G.s2s3 | N | 194 | G.s2s3.02 |
Polar | C-term | L | 406 | - | G.H3 | K | 258 | G.H3.16 |
Hydrophobic | C-term | L | 406 | - | G.H3 | K | 258 | G.H3.16 |
Van-der-waals | C-term | L | 406 | - | G.H3 | K | 258 | G.H3.16 |
Hydrophobic | ICL2 | I | 181 | 34x51 | G.S3 | L | 195 | G.S3.01 |
Van-der-waals | ICL2 | I | 181 | 34x51 | G.S3 | L | 195 | G.S3.01 |
Hydrophobic | ICL3 | T | 307 | - | G.S6 | H | 322 | G.S6.04 |
Hydrophobic | TM3 | R | 173 | 3x50 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM3 | R | 173 | 3x50 | G.H5 | L | 353 | G.H5.25 |
Polar | TM3 | R | 173 | 3x50 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | TM3 | R | 173 | 3x50 | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | TM3 | R | 173 | 3x50 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | ICL2 | P | 180 | 34x50 | G.H5 | I | 343 | G.H5.15 |
Polar | ICL2 | R | 185 | 34x55 | G.hns1 | K | 32 | G.hns1.03 |
Hydrophobic | ICL2 | R | 185 | 34x55 | G.hns1 | K | 32 | G.hns1.03 |
Van-der-waals | ICL2 | R | 185 | 34x55 | G.hns1 | K | 32 | G.hns1.03 |
Hydrophobic | TM6 | L | 325 | 6x37 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | TM6 | V | 324 | 6x36 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | ICL2 | S | 184 | 34x54 | G.H5 | I | 343 | G.H5.15 |
Hydrophobic | TM6 | A | 321 | 6x33 | G.H5 | L | 348 | G.H5.20 |
Hydrophobic | ICL2 | R | 185 | 34x55 | G.S3 | L | 195 | G.S3.01 |
Van-der-waals | ICL2 | R | 185 | 34x55 | G.S3 | L | 195 | G.S3.01 |
Hydrophobic | TM3 | I | 177 | 3x54 | G.H5 | L | 353 | G.H5.25 |
Polar | TM6 | N | 317 | 6x29 | G.H5 | Y | 354 | G.H5.26 |
Hydrophobic | TM6 | N | 317 | 6x29 | G.H5 | Y | 354 | G.H5.26 |
Van-der-waals | TM6 | N | 317 | 6x29 | G.H5 | Y | 354 | G.H5.26 |
Hydrophobic | ICL3 | T | 311 | - | G.S6 | I | 319 | G.S6.01 |
Hydrophobic | C-term | I | 409 | - | G.H3 | K | 258 | G.H3.16 |
Polar | ICL3 | Y | 306 | - | G.S6 | H | 322 | G.S6.04 |
Hydrophobic | ICL3 | Y | 306 | - | G.S6 | H | 322 | G.S6.04 |
Van-der-waals | ICL3 | Y | 306 | - | G.S6 | H | 322 | G.S6.04 |
Hydrophobic | C-term | L | 417 | - | G.H3 | L | 250 | G.H3.08 |
Hydrophobic | C-term | Y | 419 | - | G.s4h3 | L | 235 | G.s4h3.08 |
Van-der-waals | C-term | Y | 419 | - | G.s4h3 | L | 235 | G.s4h3.08 |
Hydrophobic | TM3 | A | 176 | 3x53 | G.H5 | C | 351 | G.H5.23 |
Polar | TM4 | T | 190 | 4x40 | G.HN | K | 24 | G.HN.48 |
Van-der-waals | TM4 | T | 190 | 4x40 | G.HN | K | 24 | G.HN.48 |
Hydrophobic | C-term | T | 413 | - | G.H2 | K | 210 | G.H2.05 |
Van-der-waals | C-term | T | 413 | - | G.H2 | K | 210 | G.H2.05 |