Gs -
5-HT2A receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 80.1
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 14.9
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
Gβ,
Gγ,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | TM3 | A | 176 | 3x53 | G.H5 | Y | 391 | G.H5.23 |
Van-der-waals | TM3 | A | 176 | 3x53 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | ICL2 | I | 181 | 34x51 | G.S1 | H | 41 | G.S1.02 |
Van-der-waals | ICL2 | I | 181 | 34x51 | G.S1 | H | 41 | G.S1.02 |
Hydrophobic | TM6 | K | 320 | 6x32 | G.H5 | L | 394 | G.H5.26 |
Van-der-waals | TM6 | K | 320 | 6x32 | G.H5 | L | 394 | G.H5.26 |
Hydrophobic | ICL2 | P | 180 | 34x50 | G.H5 | H | 387 | G.H5.19 |
Van-der-waals | ICL2 | P | 180 | 34x50 | G.H5 | H | 387 | G.H5.19 |
Van-der-waals | ICL3 | K | 277 | - | G.hgh4 | P | 321 | G.hgh4.11 |
Hydrophobic | TM5 | L | 261 | 5x65 | G.H5 | L | 388 | G.H5.20 |
Hydrophobic | ICL2 | I | 181 | 34x51 | G.H5 | F | 376 | G.H5.08 |
Hydrophobic | TM3 | R | 173 | 3x50 | G.H5 | L | 393 | G.H5.25 |
Polar | ICL3 | A | 276 | - | G.hgh4 | A | 324 | G.hgh4.14 |
Van-der-waals | ICL3 | A | 276 | - | G.hgh4 | A | 324 | G.hgh4.14 |
Polar | H8 | N | 384 | 8x47 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | H8 | N | 384 | 8x47 | G.H5 | E | 392 | G.H5.24 |
Van-der-waals | H8 | N | 384 | 8x47 | G.H5 | E | 392 | G.H5.24 |
Polar | TM2 | T | 109 | 2x39 | G.H5 | Q | 390 | G.H5.22 |
Van-der-waals | TM2 | T | 109 | 2x39 | G.H5 | Q | 390 | G.H5.22 |
Polar | TM2 | N | 107 | 2x37 | G.H5 | Q | 390 | G.H5.22 |
Hydrophobic | TM2 | N | 107 | 2x37 | G.H5 | Q | 390 | G.H5.22 |
Hydrophobic | ICL3 | L | 278 | - | G.hgh4 | P | 326 | G.hgh4.16 |
Polar | ICL3 | R | 275 | - | G.hgh4 | T | 325 | G.hgh4.15 |
Hydrophobic | ICL3 | R | 275 | - | G.hgh4 | T | 325 | G.hgh4.15 |
Van-der-waals | ICL3 | R | 275 | - | G.hgh4 | T | 325 | G.hgh4.15 |
Polar | TM3 | I | 177 | 3x54 | G.H5 | Q | 384 | G.H5.16 |
Hydrophobic | TM3 | I | 177 | 3x54 | G.H5 | Q | 384 | G.H5.16 |
Van-der-waals | TM3 | I | 177 | 3x54 | G.H5 | Q | 384 | G.H5.16 |
Hydrophobic | TM3 | I | 177 | 3x54 | G.H5 | L | 388 | G.H5.20 |
Van-der-waals | TM3 | I | 177 | 3x54 | G.H5 | L | 388 | G.H5.20 |
Polar | ICL3 | R | 310 | - | G.S6 | C | 359 | G.S6.01 |
Hydrophobic | ICL3 | R | 310 | - | G.S6 | C | 359 | G.S6.01 |
Van-der-waals | ICL3 | R | 310 | - | G.S6 | C | 359 | G.S6.01 |
Polar | ICL3 | L | 278 | - | G.H4 | R | 342 | G.H4.12 |
Polar | ICL3 | R | 310 | - | G.h4s6 | S | 349 | G.h4s6.02 |
Van-der-waals | ICL3 | R | 310 | - | G.h4s6 | S | 349 | G.h4s6.02 |
Hydrophobic | ICL3 | L | 278 | - | G.H4 | Y | 339 | G.H4.08 |
Van-der-waals | ICL3 | L | 278 | - | G.H4 | Y | 339 | G.H4.08 |
Hydrophobic | ICL3 | L | 278 | - | G.hgh4 | T | 325 | G.hgh4.15 |
Van-der-waals | ICL3 | L | 278 | - | G.hgh4 | T | 325 | G.hgh4.15 |
Hydrophobic | C-term | N | 412 | - | G.H3 | R | 280 | G.H3.16 |
Van-der-waals | C-term | N | 412 | - | G.H3 | R | 280 | G.H3.16 |
Polar | TM7 | F | 383 | 7x56 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | TM7 | F | 383 | 7x56 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | TM6 | A | 321 | 6x33 | G.H5 | L | 388 | G.H5.20 |
Hydrophobic | ICL2 | S | 184 | 34x54 | G.H5 | H | 387 | G.H5.19 |
Polar | ICL3 | G | 304 | - | G.hgh4 | D | 323 | G.hgh4.13 |
Hydrophobic | ICL3 | G | 304 | - | G.hgh4 | D | 323 | G.hgh4.13 |
Van-der-waals | ICL3 | G | 304 | - | G.hgh4 | D | 323 | G.hgh4.13 |
Ionic | ICL3 | R | 275 | - | G.hgh4 | E | 327 | G.hgh4.17 |
Polar | ICL3 | R | 275 | - | G.hgh4 | E | 327 | G.hgh4.17 |
Hydrophobic | ICL2 | I | 181 | 34x51 | G.H5 | I | 383 | G.H5.15 |
Van-der-waals | ICL2 | I | 181 | 34x51 | G.H5 | I | 383 | G.H5.15 |
Hydrophobic | ICL2 | I | 181 | 34x51 | G.H5 | R | 380 | G.H5.12 |
Polar | ICL3 | R | 275 | - | G.hgh4 | A | 324 | G.hgh4.14 |
Hydrophobic | ICL3 | R | 275 | - | G.hgh4 | A | 324 | G.hgh4.14 |
Van-der-waals | ICL3 | R | 275 | - | G.hgh4 | A | 324 | G.hgh4.14 |
Hydrophobic | ICL2 | I | 181 | 34x51 | G.S3 | V | 217 | G.S3.01 |
Van-der-waals | ICL2 | I | 181 | 34x51 | G.S3 | V | 217 | G.S3.01 |
Polar | ICL2 | H | 183 | 34x53 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | ICL2 | H | 183 | 34x53 | G.H5 | Y | 391 | G.H5.23 |
Van-der-waals | ICL2 | H | 183 | 34x53 | G.H5 | Y | 391 | G.H5.23 |
Polar | ICL3 | T | 307 | - | G.hgh4 | D | 323 | G.hgh4.13 |
Van-der-waals | ICL3 | T | 307 | - | G.hgh4 | D | 323 | G.hgh4.13 |
Hydrophobic | ICL2 | S | 184 | 34x54 | G.H5 | I | 383 | G.H5.15 |
Polar | TM3 | R | 173 | 3x50 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | TM3 | R | 173 | 3x50 | G.H5 | Y | 391 | G.H5.23 |
Van-der-waals | TM3 | R | 173 | 3x50 | G.H5 | Y | 391 | G.H5.23 |
Polar | ICL3 | L | 278 | - | G.hgh4 | D | 323 | G.hgh4.13 |
Hydrophobic | ICL3 | L | 278 | - | G.hgh4 | D | 323 | G.hgh4.13 |
Van-der-waals | ICL3 | L | 278 | - | G.hgh4 | D | 323 | G.hgh4.13 |
Hydrophobic | ICL3 | T | 307 | - | G.H4 | L | 346 | G.H4.16 |
Hydrophobic | TM3 | I | 177 | 3x54 | G.H5 | L | 393 | G.H5.25 |
Polar | ICL3 | K | 277 | - | G.hgh4 | A | 324 | G.hgh4.14 |
Hydrophobic | ICL3 | K | 277 | - | G.hgh4 | A | 324 | G.hgh4.14 |
Van-der-waals | ICL3 | K | 277 | - | G.hgh4 | A | 324 | G.hgh4.14 |
Hydrophobic | ICL3 | K | 277 | - | G.hgh4 | E | 322 | G.hgh4.12 |
Van-der-waals | ICL3 | K | 277 | - | G.hgh4 | E | 322 | G.hgh4.12 |
Polar | ICL3 | L | 278 | - | G.hgh4 | P | 321 | G.hgh4.11 |
Hydrophobic | ICL3 | L | 278 | - | G.hgh4 | P | 321 | G.hgh4.11 |
Van-der-waals | ICL3 | L | 278 | - | G.hgh4 | P | 321 | G.hgh4.11 |
Hydrophobic | ICL3 | L | 278 | - | G.hgh4 | E | 322 | G.hgh4.12 |
Ionic | TM5 | E | 264 | 5x68 | G.H5 | R | 380 | G.H5.12 |
Polar | TM5 | E | 264 | 5x68 | G.H5 | R | 380 | G.H5.12 |
Van-der-waals | TM5 | E | 264 | 5x68 | G.H5 | R | 380 | G.H5.12 |
Polar | TM2 | T | 109 | 2x39 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | TM2 | T | 109 | 2x39 | G.H5 | Y | 391 | G.H5.23 |
Van-der-waals | TM2 | T | 109 | 2x39 | G.H5 | Y | 391 | G.H5.23 |
Polar | ICL2 | R | 185 | 34x55 | G.s2s3 | K | 216 | G.s2s3.02 |
Van-der-waals | ICL2 | R | 185 | 34x55 | G.s2s3 | K | 216 | G.s2s3.02 |
Polar | ICL2 | N | 187 | 34x57 | G.hns1 | R | 38 | G.hns1.02 |
Polar | TM6 | A | 321 | 6x33 | G.H5 | L | 393 | G.H5.25 |
Hydrophobic | TM6 | A | 321 | 6x33 | G.H5 | L | 393 | G.H5.25 |
Van-der-waals | TM6 | A | 321 | 6x33 | G.H5 | L | 393 | G.H5.25 |
Hydrophobic | H8 | Y | 387 | 8x50 | G.H5 | E | 392 | G.H5.24 |
Van-der-waals | H8 | Y | 387 | 8x50 | G.H5 | E | 392 | G.H5.24 |
Aromatic | ICL3 | R | 310 | - | G.S6 | Y | 360 | G.S6.02 |
Polar | ICL3 | S | 305 | - | G.hgh4 | D | 323 | G.hgh4.13 |
Hydrophobic | ICL3 | S | 305 | - | G.hgh4 | D | 323 | G.hgh4.13 |
Van-der-waals | ICL3 | S | 305 | - | G.hgh4 | D | 323 | G.hgh4.13 |
Polar | ICL3 | L | 278 | - | G.hgh4 | A | 324 | G.hgh4.14 |
Hydrophobic | ICL3 | L | 278 | - | G.hgh4 | A | 324 | G.hgh4.14 |
Van-der-waals | ICL3 | L | 278 | - | G.hgh4 | A | 324 | G.hgh4.14 |
Polar | ICL3 | K | 277 | - | G.hgh4 | D | 323 | G.hgh4.13 |
Hydrophobic | ICL3 | K | 277 | - | G.hgh4 | D | 323 | G.hgh4.13 |
Van-der-waals | ICL3 | K | 277 | - | G.hgh4 | D | 323 | G.hgh4.13 |
Hydrophobic | ICL2 | P | 180 | 34x50 | G.H5 | R | 380 | G.H5.12 |
Polar | ICL3 | T | 307 | - | G.H4 | R | 342 | G.H4.12 |
Hydrophobic | ICL3 | T | 307 | - | G.H4 | R | 342 | G.H4.12 |
Van-der-waals | ICL3 | T | 307 | - | G.H4 | R | 342 | G.H4.12 |
Polar | TM5 | E | 264 | 5x68 | G.H5 | Q | 384 | G.H5.16 |
Hydrophobic | TM5 | E | 264 | 5x68 | G.H5 | Q | 384 | G.H5.16 |
Van-der-waals | TM5 | E | 264 | 5x68 | G.H5 | Q | 384 | G.H5.16 |
Hydrophobic | TM6 | V | 324 | 6x36 | G.H5 | L | 393 | G.H5.25 |
Polar | ICL3 | G | 304 | - | G.hgh4 | A | 324 | G.hgh4.14 |
Hydrophobic | ICL3 | G | 304 | - | G.hgh4 | A | 324 | G.hgh4.14 |
Van-der-waals | ICL3 | G | 304 | - | G.hgh4 | A | 324 | G.hgh4.14 |
Hydrophobic | ICL2 | H | 182 | 34x52 | G.S3 | V | 217 | G.S3.01 |
Polar | C-term | T | 413 | - | G.H3 | R | 280 | G.H3.16 |
Hydrophobic | C-term | T | 413 | - | G.H3 | R | 280 | G.H3.16 |
Van-der-waals | C-term | T | 413 | - | G.H3 | R | 280 | G.H3.16 |
Polar | TM6 | S | 314 | 6x26 | G.H5 | R | 385 | G.H5.17 |
Hydrophobic | TM6 | S | 314 | 6x26 | G.H5 | R | 385 | G.H5.17 |
Van-der-waals | TM6 | S | 314 | 6x26 | G.H5 | R | 385 | G.H5.17 |
Hydrophobic | ICL3 | L | 278 | - | G.hgh4 | T | 320 | G.hgh4.10 |
Van-der-waals | ICL3 | L | 278 | - | G.hgh4 | T | 320 | G.hgh4.10 |
Polar | TM3 | A | 176 | 3x53 | G.H5 | H | 387 | G.H5.19 |
Hydrophobic | TM3 | A | 176 | 3x53 | G.H5 | H | 387 | G.H5.19 |
Van-der-waals | TM3 | A | 176 | 3x53 | G.H5 | H | 387 | G.H5.19 |
Hydrophobic | ICL2 | P | 180 | 34x50 | G.H5 | I | 383 | G.H5.15 |
Hydrophobic | ICL3 | T | 307 | - | G.S6 | P | 361 | G.S6.03 |
Polar | ICL3 | Y | 306 | - | G.hgh4 | D | 323 | G.hgh4.13 |
Hydrophobic | ICL3 | Y | 306 | - | G.hgh4 | D | 323 | G.hgh4.13 |
Van-der-waals | ICL3 | Y | 306 | - | G.hgh4 | D | 323 | G.hgh4.13 |
Hydrophobic | TM6 | L | 325 | 6x37 | G.H5 | L | 393 | G.H5.25 |
Hydrophobic | TM7 | T | 381 | 7x54 | G.H5 | E | 392 | G.H5.24 |
Polar | TM6 | N | 317 | 6x29 | G.h4s6 | Y | 358 | G.h4s6.20 |
Hydrophobic | ICL2 | R | 185 | 34x55 | G.hns1 | A | 39 | G.hns1.03 |
Van-der-waals | ICL2 | R | 185 | 34x55 | G.hns1 | A | 39 | G.hns1.03 |
Hydrophobic | ICL3 | A | 276 | - | G.hgh4 | D | 323 | G.hgh4.13 |
Van-der-waals | ICL3 | A | 276 | - | G.hgh4 | D | 323 | G.hgh4.13 |
Polar | C-term | N | 412 | - | G.h3s5 | R | 283 | G.h3s5.01 |
Hydrophobic | C-term | N | 412 | - | G.h3s5 | R | 283 | G.h3s5.01 |
Van-der-waals | C-term | N | 412 | - | G.h3s5 | R | 283 | G.h3s5.01 |
Hydrophobic | ICL2 | P | 180 | 34x50 | G.H5 | Q | 384 | G.H5.16 |
Aromatic | ICL2 | H | 183 | 34x53 | G.H5 | H | 387 | G.H5.19 |
Hydrophobic | ICL2 | H | 183 | 34x53 | G.H5 | H | 387 | G.H5.19 |
Van-der-waals | ICL2 | H | 183 | 34x53 | G.H5 | H | 387 | G.H5.19 |
Hydrophobic | ICL3 | L | 278 | - | G.H4 | T | 335 | G.H4.04 |
Van-der-waals | ICL3 | L | 278 | - | G.H4 | T | 335 | G.H4.04 |
Polar | TM3 | D | 172 | 3x49 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | TM3 | D | 172 | 3x49 | G.H5 | Y | 391 | G.H5.23 |
Van-der-waals | TM3 | D | 172 | 3x49 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | TM6 | N | 317 | 6x29 | G.H5 | L | 394 | G.H5.26 |
Van-der-waals | TM6 | N | 317 | 6x29 | G.H5 | L | 394 | G.H5.26 |
Hydrophobic | ICL3 | R | 310 | - | G.H4 | L | 346 | G.H4.16 |
Van-der-waals | ICL3 | R | 310 | - | G.H4 | L | 346 | G.H4.16 |