G15 -
5-HT2B receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 81.5
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 11.4
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
Gβ,
Gγ,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Polar | TM2 | T | 89 | 2x39 | G.H5 | E | 370 | G.H5.22 |
Van-der-waals | TM2 | T | 89 | 2x39 | G.H5 | E | 370 | G.H5.22 |
Hydrophobic | C-term | F | 428 | - | G.H3 | L | 264 | G.H3.15 |
Polar | TM6 | A | 322 | 6x33 | G.H5 | L | 373 | G.H5.25 |
Hydrophobic | TM6 | A | 322 | 6x33 | G.H5 | L | 373 | G.H5.25 |
Hydrophobic | C-term | I | 433 | - | G.H2 | K | 213 | G.H2.01 |
Van-der-waals | C-term | I | 433 | - | G.H2 | K | 213 | G.H2.01 |
Polar | C-term | S | 425 | - | G.H2 | K | 217 | G.H2.05 |
Hydrophobic | C-term | S | 425 | - | G.H2 | K | 217 | G.H2.05 |
Van-der-waals | C-term | S | 425 | - | G.H2 | K | 217 | G.H2.05 |
Hydrophobic | C-term | F | 428 | - | G.H3 | L | 257 | G.H3.08 |
Van-der-waals | C-term | F | 428 | - | G.H3 | L | 257 | G.H3.08 |
Hydrophobic | C-term | N | 424 | - | G.H3 | W | 266 | G.H3.17 |
Van-der-waals | C-term | N | 424 | - | G.H3 | W | 266 | G.H3.17 |
Hydrophobic | C-term | L | 461 | - | G.HN | R | 30 | G.HN.45 |
Van-der-waals | C-term | L | 461 | - | G.HN | R | 30 | G.HN.45 |
Hydrophobic | C-term | P | 420 | - | G.H2 | I | 220 | G.H2.08 |
Van-der-waals | C-term | P | 420 | - | G.H2 | I | 220 | G.H2.08 |
Polar | C-term | E | 468 | - | G.HN | R | 3 | G.HN.03 |
Van-der-waals | C-term | E | 468 | - | G.HN | R | 3 | G.HN.03 |
Hydrophobic | C-term | L | 448 | - | G.H1 | R | 63 | G.H1.09 |
Van-der-waals | C-term | L | 448 | - | G.H1 | R | 63 | G.H1.09 |
Hydrophobic | C-term | E | 468 | - | G.HN | W | 7 | G.HN.07 |
Hydrophobic | ICL3 | K | 311 | - | G.H4 | T | 317 | G.H4.16 |
Polar | TM3 | R | 153 | 3x50 | G.H5 | Y | 367 | G.H5.19 |
Hydrophobic | TM3 | R | 153 | 3x50 | G.H5 | Y | 367 | G.H5.19 |
Hydrophobic | ICL3 | L | 259 | - | G.H4 | R | 310 | G.H4.09 |
Van-der-waals | ICL3 | L | 259 | - | G.H4 | R | 310 | G.H4.09 |
Polar | C-term | E | 470 | - | G.HN | R | 3 | G.HN.03 |
Hydrophobic | C-term | E | 470 | - | G.HN | R | 3 | G.HN.03 |
Van-der-waals | C-term | E | 470 | - | G.HN | R | 3 | G.HN.03 |
Hydrophobic | ICL2 | I | 161 | 34x51 | G.S3 | T | 202 | G.S3.01 |
Van-der-waals | ICL2 | I | 161 | 34x51 | G.S3 | T | 202 | G.S3.01 |
Hydrophobic | TM6 | R | 321 | 6x32 | G.H5 | L | 374 | G.H5.26 |
Van-der-waals | TM6 | R | 321 | 6x32 | G.H5 | L | 374 | G.H5.26 |
Hydrophobic | ICL3 | T | 307 | - | G.H4 | T | 317 | G.H4.16 |
Hydrophobic | TM5 | K | 247 | 5x68 | G.H5 | L | 364 | G.H5.16 |
Van-der-waals | TM5 | K | 247 | 5x68 | G.H5 | L | 364 | G.H5.16 |
Hydrophobic | C-term | N | 424 | - | G.H2 | I | 220 | G.H2.08 |
Van-der-waals | C-term | N | 424 | - | G.H2 | I | 220 | G.H2.08 |
Polar | C-term | N | 469 | - | G.HN | R | 3 | G.HN.03 |
Hydrophobic | C-term | N | 469 | - | G.HN | R | 3 | G.HN.03 |
Van-der-waals | C-term | N | 469 | - | G.HN | R | 3 | G.HN.03 |
Hydrophobic | C-term | Y | 442 | - | G.hfs2 | M | 187 | G.hfs2.03 |
Hydrophobic | C-term | N | 469 | - | G.HN | W | 7 | G.HN.07 |
Van-der-waals | C-term | N | 469 | - | G.HN | W | 7 | G.HN.07 |
Hydrophobic | C-term | M | 421 | - | G.H2 | I | 220 | G.H2.08 |
Hydrophobic | ICL2 | Q | 165 | 34x55 | G.S1 | L | 43 | G.S1.02 |
Hydrophobic | TM3 | I | 157 | 3x54 | G.H5 | L | 364 | G.H5.16 |
Hydrophobic | ICL2 | I | 161 | 34x51 | G.S1 | L | 43 | G.S1.02 |
Hydrophobic | ICL2 | I | 161 | 34x51 | G.H5 | R | 360 | G.H5.12 |
Polar | TM6 | T | 315 | 6x26 | G.h4s6 | R | 338 | G.h4s6.20 |
Hydrophobic | TM6 | T | 315 | 6x26 | G.h4s6 | R | 338 | G.h4s6.20 |
Van-der-waals | TM6 | T | 315 | 6x26 | G.h4s6 | R | 338 | G.h4s6.20 |
Hydrophobic | ICL2 | P | 160 | 34x50 | G.H5 | V | 363 | G.H5.15 |
Van-der-waals | ICL2 | P | 160 | 34x50 | G.H5 | V | 363 | G.H5.15 |
Hydrophobic | ICL3 | W | 261 | - | G.H4 | D | 314 | G.H4.13 |
Van-der-waals | ICL3 | W | 261 | - | G.H4 | D | 314 | G.H4.13 |
Polar | TM2 | Y | 87 | 2x37 | G.H5 | E | 370 | G.H5.22 |
Hydrophobic | TM2 | Y | 87 | 2x37 | G.H5 | E | 370 | G.H5.22 |
Van-der-waals | TM2 | Y | 87 | 2x37 | G.H5 | E | 370 | G.H5.22 |
Hydrophobic | ICL3 | I | 308 | - | G.H4 | L | 313 | G.H4.12 |
Van-der-waals | ICL3 | I | 308 | - | G.H4 | L | 313 | G.H4.12 |
Hydrophobic | ICL2 | P | 160 | 34x50 | G.H5 | R | 360 | G.H5.12 |
Van-der-waals | ICL2 | P | 160 | 34x50 | G.H5 | R | 360 | G.H5.12 |
Hydrophobic | ICL2 | I | 161 | 34x51 | G.H5 | V | 363 | G.H5.15 |
Polar | ICL3 | T | 307 | - | G.H4 | D | 314 | G.H4.13 |
Van-der-waals | ICL3 | T | 307 | - | G.H4 | D | 314 | G.H4.13 |
Hydrophobic | C-term | F | 428 | - | G.H2 | R | 216 | G.H2.04 |
Van-der-waals | C-term | F | 428 | - | G.H2 | R | 216 | G.H2.04 |
Hydrophobic | TM3 | I | 157 | 3x54 | G.H5 | L | 368 | G.H5.20 |
Polar | TM7 | Y | 380 | 7x53 | G.H5 | N | 372 | G.H5.24 |
Van-der-waals | TM7 | Y | 380 | 7x53 | G.H5 | N | 372 | G.H5.24 |
Polar | H8 | N | 384 | 8x47 | G.H5 | N | 372 | G.H5.24 |
Hydrophobic | H8 | N | 384 | 8x47 | G.H5 | N | 372 | G.H5.24 |
Van-der-waals | H8 | N | 384 | 8x47 | G.H5 | N | 372 | G.H5.24 |
Hydrophobic | C-term | F | 427 | - | G.H3 | T | 260 | G.H3.11 |
Van-der-waals | C-term | F | 427 | - | G.H3 | T | 260 | G.H3.11 |
Polar | C-term | N | 435 | - | G.H2 | S | 214 | G.H2.02 |
Hydrophobic | C-term | N | 435 | - | G.H2 | S | 214 | G.H2.02 |
Van-der-waals | C-term | N | 435 | - | G.H2 | S | 214 | G.H2.02 |
Hydrophobic | ICL3 | T | 307 | - | G.h4s6 | T | 321 | G.h4s6.03 |
Hydrophobic | C-term | F | 428 | - | G.H2 | K | 217 | G.H2.05 |
Hydrophobic | C-term | M | 421 | - | G.H2 | H | 221 | G.H2.09 |
Hydrophobic | C-term | L | 448 | - | H.HA | E | 74 | H.HA.03 |
Van-der-waals | C-term | L | 448 | - | H.HA | E | 74 | H.HA.03 |
Hydrophobic | C-term | L | 461 | - | G.HN | E | 27 | G.HN.42 |
Van-der-waals | C-term | L | 461 | - | G.HN | E | 27 | G.HN.42 |
Polar | ICL2 | Q | 162 | 34x52 | G.S3 | T | 202 | G.S3.01 |
Hydrophobic | TM6 | L | 326 | 6x37 | G.H5 | L | 373 | G.H5.25 |
Hydrophobic | ICL2 | P | 160 | 34x50 | G.H5 | L | 364 | G.H5.16 |
Hydrophobic | ICL3 | L | 259 | - | G.H4 | E | 306 | G.H4.05 |
Van-der-waals | ICL3 | L | 259 | - | G.H4 | E | 306 | G.H4.05 |
Hydrophobic | TM3 | A | 156 | 3x53 | G.H5 | Y | 367 | G.H5.19 |
Van-der-waals | TM3 | A | 156 | 3x53 | G.H5 | Y | 367 | G.H5.19 |
Hydrophobic | C-term | I | 433 | - | G.s4h3 | E | 248 | G.s4h3.14 |
Polar | C-term | T | 474 | - | G.HN | R | 8 | G.HN.08 |
Polar | TM3 | D | 152 | 3x49 | G.H5 | Y | 367 | G.H5.19 |
Hydrophobic | C-term | K | 429 | - | G.H2 | K | 217 | G.H2.05 |
Van-der-waals | C-term | K | 429 | - | G.H2 | K | 217 | G.H2.05 |
Hydrophobic | TM6 | V | 325 | 6x36 | G.H5 | L | 373 | G.H5.25 |
Van-der-waals | TM6 | V | 325 | 6x36 | G.H5 | L | 373 | G.H5.25 |
Polar | ICL2 | Q | 165 | 34x55 | G.hns1 | G | 41 | G.hns1.03 |
Hydrophobic | ICL2 | Q | 165 | 34x55 | G.hns1 | G | 41 | G.hns1.03 |
Van-der-waals | ICL2 | Q | 165 | 34x55 | G.hns1 | G | 41 | G.hns1.03 |
Polar | TM3 | R | 153 | 3x50 | G.H5 | I | 371 | G.H5.23 |
Hydrophobic | TM3 | R | 153 | 3x50 | G.H5 | I | 371 | G.H5.23 |
Hydrophobic | TM2 | T | 89 | 2x39 | G.H5 | Y | 367 | G.H5.19 |
Hydrophobic | C-term | Y | 442 | - | G.hfs2 | P | 188 | G.hfs2.04 |
Hydrophobic | TM6 | N | 318 | 6x29 | G.H5 | L | 374 | G.H5.26 |
Van-der-waals | TM6 | N | 318 | 6x29 | G.H5 | L | 374 | G.H5.26 |
Hydrophobic | ICL2 | N | 164 | 34x54 | G.H5 | V | 363 | G.H5.15 |
Hydrophobic | C-term | I | 433 | - | G.s4h3 | N | 245 | G.s4h3.11 |
Hydrophobic | TM7 | F | 383 | 7x56 | G.H5 | N | 372 | G.H5.24 |
Hydrophobic | C-term | I | 433 | - | G.s4h3 | E | 244 | G.s4h3.10 |
Aromatic | C-term | F | 428 | - | G.H2 | W | 219 | G.H2.07 |
Hydrophobic | C-term | F | 428 | - | G.H2 | W | 219 | G.H2.07 |
Van-der-waals | C-term | F | 428 | - | G.H2 | W | 219 | G.H2.07 |
Polar | ICL3 | K | 311 | - | G.S6 | L | 339 | G.S6.01 |
Hydrophobic | ICL3 | K | 311 | - | G.S6 | L | 339 | G.S6.01 |
Van-der-waals | ICL3 | K | 311 | - | G.S6 | L | 339 | G.S6.01 |
Hydrophobic | ICL2 | I | 161 | 34x51 | G.H5 | F | 356 | G.H5.08 |
Van-der-waals | ICL2 | I | 161 | 34x51 | G.H5 | F | 356 | G.H5.08 |
Hydrophobic | C-term | Y | 442 | - | H.hbhc | Y | 122 | H.hbhc.01 |
Van-der-waals | C-term | Y | 442 | - | H.hbhc | Y | 122 | H.hbhc.01 |
Hydrophobic | C-term | F | 428 | - | G.h2s4 | F | 223 | G.h2s4.01 |