Golf -
5-HT2B receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 75.3
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.6
iPTM Score: 0.5
PAE mean: 18.5
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Polar | H8 | N | 384 | 8x47 | G.H5 | E | 379 | G.H5.24 |
Hydrophobic | H8 | N | 384 | 8x47 | G.H5 | E | 379 | G.H5.24 |
Van-der-waals | H8 | N | 384 | 8x47 | G.H5 | E | 379 | G.H5.24 |
Polar | TM3 | D | 152 | 3x49 | G.H5 | Y | 378 | G.H5.23 |
Hydrophobic | TM3 | D | 152 | 3x49 | G.H5 | Y | 378 | G.H5.23 |
Polar | ICL3 | S | 306 | - | G.hgh4 | D | 310 | G.hgh4.13 |
Hydrophobic | ICL3 | S | 306 | - | G.hgh4 | D | 310 | G.hgh4.13 |
Van-der-waals | ICL3 | S | 306 | - | G.hgh4 | D | 310 | G.hgh4.13 |
Polar | TM6 | A | 322 | 6x33 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | TM6 | A | 322 | 6x33 | G.H5 | L | 380 | G.H5.25 |
Van-der-waals | TM6 | A | 322 | 6x33 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | ICL2 | P | 160 | 34x50 | G.H5 | Q | 371 | G.H5.16 |
Van-der-waals | ICL2 | P | 160 | 34x50 | G.H5 | Q | 371 | G.H5.16 |
Hydrophobic | ICL3 | W | 261 | - | G.H4 | L | 333 | G.H4.16 |
Hydrophobic | ICL2 | N | 164 | 34x54 | G.H5 | I | 370 | G.H5.15 |
Hydrophobic | TM3 | A | 156 | 3x53 | G.H5 | H | 374 | G.H5.19 |
Polar | ICL2 | P | 160 | 34x50 | G.H5 | H | 374 | G.H5.19 |
Hydrophobic | ICL2 | P | 160 | 34x50 | G.H5 | H | 374 | G.H5.19 |
Van-der-waals | ICL2 | P | 160 | 34x50 | G.H5 | H | 374 | G.H5.19 |
Polar | ICL3 | T | 260 | - | G.hgh4 | D | 314 | G.hgh4.17 |
Hydrophobic | ICL3 | T | 260 | - | G.hgh4 | D | 314 | G.hgh4.17 |
Van-der-waals | ICL3 | T | 260 | - | G.hgh4 | D | 314 | G.hgh4.17 |
Polar | TM2 | T | 89 | 2x39 | G.H5 | Q | 377 | G.H5.22 |
Hydrophobic | ICL2 | Y | 166 | 34x56 | G.HN | L | 37 | G.HN.52 |
Hydrophobic | ICL2 | P | 160 | 34x50 | G.H5 | I | 370 | G.H5.15 |
Van-der-waals | ICL2 | P | 160 | 34x50 | G.H5 | I | 370 | G.H5.15 |
Polar | ICL2 | N | 167 | 34x57 | G.hns1 | K | 40 | G.hns1.02 |
Van-der-waals | ICL2 | N | 167 | 34x57 | G.hns1 | K | 40 | G.hns1.02 |
Polar | ICL3 | K | 311 | - | G.H5 | R | 372 | G.H5.17 |
Van-der-waals | ICL3 | K | 311 | - | G.H5 | R | 372 | G.H5.17 |
Hydrophobic | ICL2 | I | 161 | 34x51 | G.H5 | I | 370 | G.H5.15 |
Van-der-waals | ICL2 | I | 161 | 34x51 | G.H5 | I | 370 | G.H5.15 |
Polar | ICL3 | K | 311 | - | G.S6 | C | 346 | G.S6.01 |
Hydrophobic | ICL3 | K | 311 | - | G.S6 | C | 346 | G.S6.01 |
Van-der-waals | ICL3 | K | 311 | - | G.S6 | C | 346 | G.S6.01 |
Hydrophobic | TM7 | Y | 380 | 7x53 | G.H5 | E | 379 | G.H5.24 |
Van-der-waals | TM7 | Y | 380 | 7x53 | G.H5 | E | 379 | G.H5.24 |
Hydrophobic | ICL3 | S | 306 | - | G.hgh4 | A | 311 | G.hgh4.14 |
Hydrophobic | TM6 | A | 322 | 6x33 | G.H5 | L | 375 | G.H5.20 |
Hydrophobic | TM3 | A | 156 | 3x53 | G.H5 | Y | 378 | G.H5.23 |
Van-der-waals | TM3 | A | 156 | 3x53 | G.H5 | Y | 378 | G.H5.23 |
Hydrophobic | ICL3 | L | 259 | - | G.H5 | R | 361 | G.H5.06 |
Van-der-waals | ICL3 | L | 259 | - | G.H5 | R | 361 | G.H5.06 |
Van-der-waals | TM4 | S | 168 | 4x38 | G.hns1 | K | 40 | G.hns1.02 |
Hydrophobic | TM6 | V | 325 | 6x36 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | ICL2 | A | 163 | 34x53 | G.H5 | H | 374 | G.H5.19 |
Polar | TM5 | K | 247 | 5x68 | G.H5 | Q | 371 | G.H5.16 |
Hydrophobic | TM5 | K | 247 | 5x68 | G.H5 | Q | 371 | G.H5.16 |
Van-der-waals | TM5 | K | 247 | 5x68 | G.H5 | Q | 371 | G.H5.16 |
Hydrophobic | ICL3 | K | 311 | - | G.S6 | P | 348 | G.S6.03 |
Hydrophobic | TM3 | I | 157 | 3x54 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | TM6 | N | 318 | 6x29 | G.H5 | L | 381 | G.H5.26 |
Van-der-waals | TM6 | N | 318 | 6x29 | G.H5 | L | 381 | G.H5.26 |
Hydrophobic | ICL2 | P | 160 | 34x50 | G.H5 | R | 367 | G.H5.12 |
Hydrophobic | ICL3 | W | 261 | - | G.S6 | H | 349 | G.S6.04 |
Hydrophobic | TM5 | L | 244 | 5x65 | G.H5 | L | 375 | G.H5.20 |
Aromatic | ICL3 | W | 261 | - | G.S6 | F | 350 | G.S6.05 |
Hydrophobic | ICL3 | W | 261 | - | G.S6 | F | 350 | G.S6.05 |
Van-der-waals | ICL3 | W | 261 | - | G.S6 | F | 350 | G.S6.05 |
Hydrophobic | ICL2 | I | 161 | 34x51 | G.S1 | H | 43 | G.S1.02 |
Van-der-waals | ICL2 | I | 161 | 34x51 | G.S1 | H | 43 | G.S1.02 |
Van-der-waals | ICL3 | R | 258 | - | G.hgh4 | D | 314 | G.hgh4.17 |
Hydrophobic | C-term | L | 465 | - | G.H3 | R | 267 | G.H3.16 |
Van-der-waals | C-term | L | 465 | - | G.H3 | R | 267 | G.H3.16 |
Polar | ICL2 | N | 164 | 34x54 | G.H5 | H | 374 | G.H5.19 |
Hydrophobic | ICL2 | N | 164 | 34x54 | G.H5 | H | 374 | G.H5.19 |
Van-der-waals | ICL2 | N | 164 | 34x54 | G.H5 | H | 374 | G.H5.19 |
Polar | ICL3 | T | 260 | - | G.H4 | K | 325 | G.H4.07 |
Hydrophobic | ICL2 | I | 161 | 34x51 | G.H5 | F | 363 | G.H5.08 |
Hydrophobic | ICL3 | T | 307 | - | G.H4 | L | 333 | G.H4.16 |
Van-der-waals | ICL3 | T | 307 | - | G.H4 | L | 333 | G.H4.16 |
Polar | TM3 | R | 153 | 3x50 | G.H5 | Y | 378 | G.H5.23 |
Hydrophobic | TM3 | R | 153 | 3x50 | G.H5 | Y | 378 | G.H5.23 |
Van-der-waals | TM3 | R | 153 | 3x50 | G.H5 | Y | 378 | G.H5.23 |
Hydrophobic | ICL3 | W | 261 | - | G.S6 | P | 348 | G.S6.03 |
Van-der-waals | ICL3 | W | 261 | - | G.S6 | P | 348 | G.S6.03 |
Polar | ICL3 | T | 260 | - | G.hgh4 | T | 312 | G.hgh4.15 |
Hydrophobic | ICL3 | T | 260 | - | G.hgh4 | T | 312 | G.hgh4.15 |
Van-der-waals | ICL3 | T | 260 | - | G.hgh4 | T | 312 | G.hgh4.15 |
Hydrophobic | H8 | F | 387 | 8x50 | G.H5 | E | 379 | G.H5.24 |
Van-der-waals | H8 | F | 387 | 8x50 | G.H5 | E | 379 | G.H5.24 |
Polar | ICL3 | T | 307 | - | G.H4 | R | 329 | G.H4.12 |
Van-der-waals | ICL3 | T | 307 | - | G.H4 | R | 329 | G.H4.12 |
Polar | TM7 | T | 381 | 7x54 | G.H5 | E | 379 | G.H5.24 |
Hydrophobic | TM7 | T | 381 | 7x54 | G.H5 | E | 379 | G.H5.24 |
Van-der-waals | TM7 | T | 381 | 7x54 | G.H5 | E | 379 | G.H5.24 |
Hydrophobic | ICL3 | L | 259 | - | G.S6 | F | 350 | G.S6.05 |
Van-der-waals | ICL3 | L | 259 | - | G.S6 | F | 350 | G.S6.05 |
Hydrophobic | ICL2 | I | 161 | 34x51 | G.S3 | V | 204 | G.S3.01 |
Van-der-waals | ICL2 | I | 161 | 34x51 | G.S3 | V | 204 | G.S3.01 |
Polar | ICL3 | S | 306 | - | G.H4 | R | 329 | G.H4.12 |
Hydrophobic | ICL3 | S | 306 | - | G.H4 | R | 329 | G.H4.12 |
Van-der-waals | ICL3 | S | 306 | - | G.H4 | R | 329 | G.H4.12 |
Hydrophobic | ICL3 | S | 306 | - | G.H4 | F | 326 | G.H4.08 |
Aromatic | ICL3 | K | 311 | - | G.S6 | Y | 347 | G.S6.02 |
Hydrophobic | ICL3 | K | 311 | - | G.S6 | Y | 347 | G.S6.02 |
Van-der-waals | ICL3 | K | 311 | - | G.S6 | Y | 347 | G.S6.02 |
Hydrophobic | ICL3 | L | 262 | - | G.hgh4 | T | 312 | G.hgh4.15 |
Van-der-waals | ICL3 | L | 262 | - | G.hgh4 | T | 312 | G.hgh4.15 |
Hydrophobic | ICL3 | L | 259 | - | G.H5 | E | 357 | G.H5.02 |
Van-der-waals | ICL3 | L | 259 | - | G.H5 | E | 357 | G.H5.02 |
Hydrophobic | ICL2 | Q | 165 | 34x55 | G.hns1 | K | 40 | G.hns1.02 |
Van-der-waals | ICL2 | Q | 165 | 34x55 | G.hns1 | K | 40 | G.hns1.02 |
Polar | ICL2 | Q | 165 | 34x55 | G.hns1 | A | 41 | G.hns1.03 |
Hydrophobic | ICL2 | Q | 165 | 34x55 | G.hns1 | A | 41 | G.hns1.03 |
Van-der-waals | ICL2 | Q | 165 | 34x55 | G.hns1 | A | 41 | G.hns1.03 |
Aromatic | ICL3 | W | 261 | - | G.H4 | R | 329 | G.H4.12 |
Hydrophobic | ICL3 | W | 261 | - | G.H4 | R | 329 | G.H4.12 |
Van-der-waals | ICL3 | W | 261 | - | G.H4 | R | 329 | G.H4.12 |
Hydrophobic | TM2 | Y | 87 | 2x37 | G.H5 | Q | 377 | G.H5.22 |
Hydrophobic | TM3 | I | 157 | 3x54 | G.H5 | L | 375 | G.H5.20 |
Polar | TM6 | T | 315 | 6x26 | G.H5 | D | 368 | G.H5.13 |
Van-der-waals | TM6 | T | 315 | 6x26 | G.H5 | D | 368 | G.H5.13 |
Van-der-waals | TM6 | R | 321 | 6x32 | G.H5 | L | 381 | G.H5.26 |
Polar | TM6 | T | 315 | 6x26 | G.H5 | R | 372 | G.H5.17 |
Van-der-waals | TM6 | T | 315 | 6x26 | G.H5 | R | 372 | G.H5.17 |
Hydrophobic | C-term | L | 465 | - | G.H2 | I | 222 | G.H2.08 |
Hydrophobic | TM3 | R | 153 | 3x50 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | TM2 | T | 89 | 2x39 | G.H5 | Y | 378 | G.H5.23 |
Van-der-waals | TM2 | T | 89 | 2x39 | G.H5 | Y | 378 | G.H5.23 |
Hydrophobic | C-term | L | 465 | - | G.H3 | W | 268 | G.H3.17 |
Hydrophobic | ICL3 | T | 260 | - | G.hgh4 | P | 313 | G.hgh4.16 |
Van-der-waals | ICL3 | T | 260 | - | G.hgh4 | P | 313 | G.hgh4.16 |