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5-HT2B receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 83.0
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.8
iPTM Score: 0.7
PAE mean: 12.8
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
Gβ,
Gγ,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Polar | C-term | G | 436 | - | G.H1 | K | 54 | G.H1.09 |
Polar | ICL3 | T | 307 | - | G.H4 | E | 309 | G.H4.16 |
Hydrophobic | ICL3 | T | 307 | - | G.H4 | E | 309 | G.H4.16 |
Van-der-waals | ICL3 | T | 307 | - | G.H4 | E | 309 | G.H4.16 |
Hydrophobic | TM5 | K | 247 | 5x68 | G.H5 | I | 344 | G.H5.16 |
Van-der-waals | TM5 | K | 247 | 5x68 | G.H5 | I | 344 | G.H5.16 |
Polar | ICL3 | K | 311 | - | G.S6 | I | 319 | G.S6.01 |
Hydrophobic | ICL3 | K | 311 | - | G.S6 | I | 319 | G.S6.01 |
Van-der-waals | ICL3 | K | 311 | - | G.S6 | I | 319 | G.S6.01 |
Hydrophobic | TM6 | R | 321 | 6x32 | G.H5 | Y | 354 | G.H5.26 |
Van-der-waals | TM6 | R | 321 | 6x32 | G.H5 | Y | 354 | G.H5.26 |
Hydrophobic | TM6 | T | 315 | 6x26 | G.H5 | D | 341 | G.H5.13 |
Hydrophobic | C-term | F | 428 | - | H.hbhc | T | 117 | H.hbhc.05 |
Polar | TM6 | T | 315 | 6x26 | G.h4s6 | E | 318 | G.h4s6.12 |
Hydrophobic | C-term | F | 417 | - | G.H3 | L | 250 | G.H3.08 |
Van-der-waals | C-term | F | 417 | - | G.H3 | L | 250 | G.H3.08 |
Polar | ICL3 | Q | 257 | - | G.S6 | H | 322 | G.S6.04 |
Hydrophobic | ICL3 | Q | 257 | - | G.S6 | H | 322 | G.S6.04 |
Van-der-waals | ICL3 | Q | 257 | - | G.S6 | H | 322 | G.S6.04 |
Hydrophobic | TM3 | A | 156 | 3x53 | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | ICL3 | K | 311 | - | G.S6 | C | 321 | G.S6.03 |
Polar | TM6 | N | 318 | 6x29 | G.H5 | Y | 354 | G.H5.26 |
Hydrophobic | TM6 | N | 318 | 6x29 | G.H5 | Y | 354 | G.H5.26 |
Van-der-waals | TM6 | N | 318 | 6x29 | G.H5 | Y | 354 | G.H5.26 |
Hydrophobic | TM7 | F | 383 | 7x56 | G.H5 | G | 352 | G.H5.24 |
Van-der-waals | TM7 | F | 383 | 7x56 | G.H5 | G | 352 | G.H5.24 |
Hydrophobic | C-term | P | 420 | - | G.s4h3 | E | 237 | G.s4h3.10 |
Van-der-waals | C-term | P | 420 | - | G.s4h3 | E | 237 | G.s4h3.10 |
Hydrophobic | ICL2 | P | 160 | 34x50 | G.H5 | I | 343 | G.H5.15 |
Hydrophobic | ICL2 | I | 161 | 34x51 | G.S3 | L | 195 | G.S3.01 |
Van-der-waals | ICL2 | I | 161 | 34x51 | G.S3 | L | 195 | G.S3.01 |
Hydrophobic | ICL2 | P | 160 | 34x50 | G.H5 | I | 344 | G.H5.16 |
Van-der-waals | ICL2 | P | 160 | 34x50 | G.H5 | I | 344 | G.H5.16 |
Hydrophobic | ICL2 | I | 161 | 34x51 | G.H5 | F | 336 | G.H5.08 |
Hydrophobic | TM6 | Q | 314 | 6x25 | G.h4s6 | E | 318 | G.h4s6.12 |
Hydrophobic | TM6 | V | 325 | 6x36 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | ICL3 | L | 259 | - | G.S6 | M | 323 | G.S6.05 |
Van-der-waals | ICL3 | L | 259 | - | G.S6 | M | 323 | G.S6.05 |
Polar | TM6 | N | 318 | 6x29 | G.h4s6 | E | 318 | G.h4s6.12 |
Hydrophobic | C-term | I | 415 | - | G.H3 | S | 253 | G.H3.11 |
Polar | TM6 | A | 322 | 6x33 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | TM6 | A | 322 | 6x33 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM6 | A | 322 | 6x33 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | C-term | F | 417 | - | G.H3 | E | 246 | G.H3.04 |
Polar | C-term | S | 425 | - | G.hfs2 | K | 181 | G.hfs2.04 |
Hydrophobic | C-term | S | 425 | - | G.hfs2 | K | 181 | G.hfs2.04 |
Van-der-waals | C-term | S | 425 | - | G.hfs2 | K | 181 | G.hfs2.04 |
Polar | C-term | N | 424 | - | H.HA | Q | 79 | H.HA.17 |
Hydrophobic | C-term | N | 424 | - | H.HA | Q | 79 | H.HA.17 |
Van-der-waals | C-term | N | 424 | - | H.HA | Q | 79 | H.HA.17 |
Polar | C-term | M | 421 | - | G.H2 | R | 206 | G.H2.01 |
Hydrophobic | C-term | M | 421 | - | G.H2 | R | 206 | G.H2.01 |
Van-der-waals | C-term | M | 421 | - | G.H2 | R | 206 | G.H2.01 |
Hydrophobic | TM3 | I | 157 | 3x54 | G.H5 | L | 348 | G.H5.20 |
Polar | ICL2 | P | 160 | 34x50 | G.H5 | N | 347 | G.H5.19 |
Van-der-waals | ICL2 | P | 160 | 34x50 | G.H5 | N | 347 | G.H5.19 |
Ionic | TM5 | K | 254 | 5x75 | G.H5 | D | 337 | G.H5.09 |
Polar | TM5 | K | 254 | 5x75 | G.H5 | D | 337 | G.H5.09 |
Van-der-waals | TM5 | K | 254 | 5x75 | G.H5 | D | 337 | G.H5.09 |
Ionic | ICL3 | K | 311 | - | G.H4 | E | 309 | G.H4.16 |
Polar | ICL3 | K | 311 | - | G.H4 | E | 309 | G.H4.16 |
Van-der-waals | ICL3 | K | 311 | - | G.H4 | E | 309 | G.H4.16 |
Hydrophobic | C-term | R | 418 | - | G.s4h3 | E | 237 | G.s4h3.10 |
Van-der-waals | C-term | R | 418 | - | G.s4h3 | E | 237 | G.s4h3.10 |
Polar | C-term | N | 419 | - | G.H2 | R | 206 | G.H2.01 |
Hydrophobic | C-term | N | 419 | - | G.H2 | R | 206 | G.H2.01 |
Van-der-waals | C-term | N | 419 | - | G.H2 | R | 206 | G.H2.01 |
Hydrophobic | ICL3 | K | 311 | - | G.S6 | Y | 320 | G.S6.02 |
Van-der-waals | ICL3 | K | 311 | - | G.S6 | Y | 320 | G.S6.02 |
Hydrophobic | TM3 | I | 157 | 3x54 | G.H5 | L | 353 | G.H5.25 |
Polar | TM2 | Y | 87 | 2x37 | G.H5 | G | 350 | G.H5.22 |
Hydrophobic | ICL2 | I | 161 | 34x51 | G.H5 | T | 340 | G.H5.12 |
Hydrophobic | TM3 | R | 153 | 3x50 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM3 | R | 153 | 3x50 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | C-term | I | 433 | - | H.HA | Q | 68 | H.HA.06 |
Van-der-waals | C-term | I | 433 | - | H.HA | Q | 68 | H.HA.06 |
Hydrophobic | C-term | F | 427 | - | H.hbhc | M | 114 | H.hbhc.02 |
Van-der-waals | C-term | F | 427 | - | H.hbhc | M | 114 | H.hbhc.02 |
Hydrophobic | ICL3 | S | 306 | - | G.H4 | Q | 305 | G.H4.12 |
Polar | ICL2 | Q | 165 | 34x55 | G.s2s3 | N | 194 | G.s2s3.02 |
Van-der-waals | ICL3 | T | 260 | - | G.H4 | A | 302 | G.H4.08 |
Hydrophobic | TM6 | A | 322 | 6x33 | G.H5 | L | 348 | G.H5.20 |
Hydrophobic | ICL3 | L | 259 | - | G.H4 | E | 298 | G.H4.04 |
Van-der-waals | ICL3 | L | 259 | - | G.H4 | E | 298 | G.H4.04 |
Hydrophobic | ICL2 | P | 160 | 34x50 | G.H5 | T | 340 | G.H5.12 |
Polar | TM3 | A | 156 | 3x53 | G.H5 | N | 347 | G.H5.19 |
Polar | ICL3 | T | 260 | - | G.H4 | E | 298 | G.H4.04 |
Hydrophobic | ICL3 | T | 260 | - | G.H4 | E | 298 | G.H4.04 |
Hydrophobic | TM6 | L | 326 | 6x37 | G.H5 | L | 353 | G.H5.25 |
Polar | TM3 | R | 153 | 3x50 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | TM3 | R | 153 | 3x50 | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | TM3 | R | 153 | 3x50 | G.H5 | C | 351 | G.H5.23 |
Polar | C-term | M | 421 | - | G.hfs2 | K | 181 | G.hfs2.04 |
Hydrophobic | ICL2 | Q | 165 | 34x55 | G.hns1 | K | 32 | G.hns1.03 |
Hydrophobic | ICL3 | L | 259 | - | G.H4 | A | 301 | G.H4.07 |
Hydrophobic | C-term | I | 437 | - | G.S2 | V | 186 | G.S2.02 |
Hydrophobic | C-term | M | 421 | - | G.hfs2 | R | 179 | G.hfs2.02 |
Van-der-waals | C-term | M | 421 | - | G.hfs2 | R | 179 | G.hfs2.02 |
Aromatic | C-term | F | 417 | - | G.H2 | R | 209 | G.H2.04 |
Hydrophobic | C-term | F | 417 | - | G.H2 | R | 209 | G.H2.04 |
Van-der-waals | C-term | F | 417 | - | G.H2 | R | 209 | G.H2.04 |
Hydrophobic | C-term | Y | 416 | - | G.H2 | E | 208 | G.H2.03 |