G12 -
5-HT2C receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 83.6
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.8
iPTM Score: 0.7
PAE mean: 12.7
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
Gβ,
Gγ,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Polar | TM3 | R | 152 | 3x50 | G.H5 | I | 378 | G.H5.23 |
Hydrophobic | TM3 | R | 152 | 3x50 | G.H5 | I | 378 | G.H5.23 |
Hydrophobic | ICL2 | P | 159 | 34x50 | G.H5 | K | 367 | G.H5.12 |
Van-der-waals | ICL2 | P | 159 | 34x50 | G.H5 | K | 367 | G.H5.12 |
Hydrophobic | TM6 | E | 306 | 6x30 | G.H5 | L | 375 | G.H5.20 |
Van-der-waals | TM6 | E | 306 | 6x30 | G.H5 | L | 375 | G.H5.20 |
Hydrophobic | TM5 | L | 241 | 5x65 | G.H5 | L | 375 | G.H5.20 |
Hydrophobic | C-term | N | 414 | - | G.H3 | K | 284 | G.H3.16 |
Hydrophobic | ICL2 | F | 165 | 34x56 | G.hns1 | R | 56 | G.hns1.03 |
Van-der-waals | ICL2 | F | 165 | 34x56 | G.hns1 | R | 56 | G.hns1.03 |
Polar | TM6 | A | 302 | 6x26 | G.H5 | Q | 372 | G.H5.17 |
Hydrophobic | TM6 | A | 302 | 6x26 | G.H5 | Q | 372 | G.H5.17 |
Hydrophobic | ICL2 | I | 160 | 34x51 | G.H5 | I | 370 | G.H5.15 |
Hydrophobic | C-term | N | 412 | - | G.H3 | K | 284 | G.H3.16 |
Hydrophobic | TM6 | K | 308 | 6x32 | G.H5 | M | 379 | G.H5.24 |
Van-der-waals | TM6 | K | 308 | 6x32 | G.H5 | M | 379 | G.H5.24 |
Polar | TM6 | E | 306 | 6x30 | G.H5 | Q | 372 | G.H5.17 |
Van-der-waals | TM6 | E | 306 | 6x30 | G.H5 | Q | 372 | G.H5.17 |
Hydrophobic | ICL3 | H | 252 | - | G.S6 | H | 348 | G.S6.03 |
Hydrophobic | ICL2 | P | 159 | 34x50 | G.H5 | I | 370 | G.H5.15 |
Van-der-waals | ICL2 | P | 159 | 34x50 | G.H5 | I | 370 | G.H5.15 |
Hydrophobic | TM3 | I | 156 | 3x54 | G.H5 | I | 378 | G.H5.23 |
Hydrophobic | ICL2 | E | 161 | 34x52 | G.S3 | I | 221 | G.S3.01 |
Polar | ICL2 | R | 164 | 34x55 | G.h2s4 | T | 246 | G.h2s4.05 |
Van-der-waals | ICL2 | R | 164 | 34x55 | G.h2s4 | T | 246 | G.h2s4.05 |
Hydrophobic | ICL2 | R | 164 | 34x55 | G.S1 | V | 58 | G.S1.02 |
Hydrophobic | TM6 | Q | 301 | 6x25 | G.h4s6 | S | 343 | G.h4s6.12 |
Van-der-waals | TM6 | Q | 301 | 6x25 | G.h4s6 | S | 343 | G.h4s6.12 |
Hydrophobic | ICL2 | I | 160 | 34x51 | G.H5 | K | 367 | G.H5.12 |
Hydrophobic | ICL2 | S | 163 | 34x54 | G.H5 | I | 370 | G.H5.15 |
Hydrophobic | ICL2 | I | 160 | 34x51 | G.S1 | V | 58 | G.S1.02 |
Hydrophobic | H8 | K | 373 | 8x48 | G.H5 | Q | 381 | G.H5.26 |
Van-der-waals | H8 | K | 373 | 8x48 | G.H5 | Q | 381 | G.H5.26 |
Hydrophobic | TM6 | A | 309 | 6x33 | G.H5 | M | 379 | G.H5.24 |
Van-der-waals | TM6 | A | 309 | 6x33 | G.H5 | M | 379 | G.H5.24 |
Polar | ICL2 | N | 166 | 34x57 | G.hns1 | R | 55 | G.hns1.02 |
Hydrophobic | ICL2 | N | 166 | 34x57 | G.hns1 | R | 55 | G.hns1.02 |
Van-der-waals | ICL2 | N | 166 | 34x57 | G.hns1 | R | 55 | G.hns1.02 |
Polar | C-term | R | 409 | - | G.h4s6 | R | 340 | G.h4s6.09 |
Polar | ICL3 | G | 298 | - | G.h4s6 | R | 342 | G.h4s6.11 |
Van-der-waals | ICL3 | G | 298 | - | G.h4s6 | R | 342 | G.h4s6.11 |
Polar | TM6 | N | 305 | 6x29 | G.H5 | Q | 372 | G.H5.17 |
Van-der-waals | TM6 | N | 305 | 6x29 | G.H5 | Q | 372 | G.H5.17 |
Hydrophobic | TM7 | F | 371 | 7x56 | G.H5 | M | 379 | G.H5.24 |
Van-der-waals | TM7 | F | 371 | 7x56 | G.H5 | M | 379 | G.H5.24 |
Hydrophobic | ICL2 | I | 160 | 34x51 | G.H5 | F | 363 | G.H5.08 |
Hydrophobic | C-term | E | 410 | - | G.h4s6 | R | 340 | G.h4s6.09 |
Hydrophobic | TM2 | L | 92 | 2x43 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | H8 | N | 372 | 8x47 | G.H5 | Q | 381 | G.H5.26 |
Van-der-waals | H8 | N | 372 | 8x47 | G.H5 | Q | 381 | G.H5.26 |
Hydrophobic | TM6 | A | 309 | 6x33 | G.H5 | L | 375 | G.H5.20 |
Hydrophobic | TM7 | F | 371 | 7x56 | G.H5 | L | 380 | G.H5.25 |
Van-der-waals | TM7 | F | 371 | 7x56 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | ICL3 | G | 298 | - | G.h4s6 | S | 343 | G.h4s6.12 |
Polar | TM5 | Q | 244 | 5x68 | G.H5 | D | 368 | G.H5.13 |
Hydrophobic | TM5 | Q | 244 | 5x68 | G.H5 | D | 368 | G.H5.13 |
Van-der-waals | TM5 | Q | 244 | 5x68 | G.H5 | D | 368 | G.H5.13 |
Hydrophobic | TM7 | Y | 368 | 7x53 | G.H5 | L | 380 | G.H5.25 |
Van-der-waals | TM7 | Y | 368 | 7x53 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | TM6 | K | 308 | 6x32 | G.H5 | Q | 381 | G.H5.26 |
Van-der-waals | TM6 | K | 308 | 6x32 | G.H5 | Q | 381 | G.H5.26 |
Polar | ICL2 | R | 164 | 34x55 | G.hns1 | R | 55 | G.hns1.02 |
Hydrophobic | ICL2 | R | 164 | 34x55 | G.hns1 | R | 55 | G.hns1.02 |
Van-der-waals | ICL2 | R | 164 | 34x55 | G.hns1 | R | 55 | G.hns1.02 |
Polar | C-term | V | 413 | - | G.H3 | K | 284 | G.H3.16 |
Hydrophobic | C-term | V | 413 | - | G.H3 | K | 284 | G.H3.16 |
Van-der-waals | C-term | V | 413 | - | G.H3 | K | 284 | G.H3.16 |
Hydrophobic | TM4 | S | 167 | 4x38 | G.hns1 | R | 55 | G.hns1.02 |
Hydrophobic | ICL2 | I | 160 | 34x51 | G.H5 | V | 366 | G.H5.11 |
Polar | ICL3 | G | 298 | - | G.h4s6 | P | 345 | G.h4s6.20 |
Hydrophobic | ICL3 | G | 298 | - | G.h4s6 | P | 345 | G.h4s6.20 |
Hydrophobic | TM3 | A | 155 | 3x53 | G.H5 | I | 378 | G.H5.23 |
Hydrophobic | ICL2 | I | 160 | 34x51 | G.S3 | I | 221 | G.S3.01 |
Polar | ICL2 | P | 159 | 34x50 | G.H5 | N | 374 | G.H5.19 |
Hydrophobic | TM6 | L | 313 | 6x37 | G.H5 | I | 378 | G.H5.23 |
Polar | H8 | N | 372 | 8x47 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | H8 | N | 372 | 8x47 | G.H5 | L | 380 | G.H5.25 |
Van-der-waals | H8 | N | 372 | 8x47 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | ICL2 | R | 164 | 34x55 | G.hns1 | R | 56 | G.hns1.03 |
Van-der-waals | ICL2 | R | 164 | 34x55 | G.hns1 | R | 56 | G.hns1.03 |
Hydrophobic | C-term | L | 411 | - | G.H2 | Q | 236 | G.H2.05 |
Hydrophobic | ICL3 | T | 299 | - | G.h4s6 | P | 345 | G.h4s6.20 |
Hydrophobic | TM3 | I | 156 | 3x54 | G.H5 | L | 375 | G.H5.20 |
Polar | ICL2 | R | 164 | 34x55 | G.S1 | L | 57 | G.S1.01 |
Hydrophobic | ICL2 | R | 164 | 34x55 | G.S1 | L | 57 | G.S1.01 |
Van-der-waals | ICL2 | R | 164 | 34x55 | G.S1 | L | 57 | G.S1.01 |
Hydrophobic | TM6 | N | 305 | 6x29 | G.H5 | M | 379 | G.H5.24 |
Van-der-waals | TM6 | N | 305 | 6x29 | G.H5 | M | 379 | G.H5.24 |
Hydrophobic | H8 | Y | 375 | 8x50 | G.H5 | L | 380 | G.H5.25 |
Polar | TM3 | A | 155 | 3x53 | G.H5 | N | 374 | G.H5.19 |
Van-der-waals | TM3 | A | 155 | 3x53 | G.H5 | N | 374 | G.H5.19 |
Hydrophobic | C-term | I | 415 | - | G.H3 | K | 284 | G.H3.16 |
Van-der-waals | C-term | I | 415 | - | G.H3 | K | 284 | G.H3.16 |
Hydrophobic | TM3 | I | 156 | 3x54 | G.H5 | L | 371 | G.H5.16 |
Polar | TM3 | R | 157 | 3x55 | G.H5 | K | 367 | G.H5.12 |
Ionic | C-term | H | 418 | - | G.h2s4 | D | 243 | G.h2s4.02 |
Polar | C-term | H | 418 | - | G.h2s4 | D | 243 | G.h2s4.02 |
Hydrophobic | C-term | H | 418 | - | G.h2s4 | D | 243 | G.h2s4.02 |
Hydrophobic | TM5 | Q | 244 | 5x68 | G.H5 | L | 371 | G.H5.16 |
Hydrophobic | ICL2 | P | 159 | 34x50 | G.H5 | L | 371 | G.H5.16 |
Hydrophobic | ICL3 | G | 298 | - | G.h4s6 | K | 344 | G.h4s6.19 |
Van-der-waals | ICL3 | G | 298 | - | G.h4s6 | K | 344 | G.h4s6.19 |