G15 -
5-HT2C receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 84.7
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.8
iPTM Score: 0.7
PAE mean: 11.0
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
Gβ,
Gγ,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | C-term | V | 458 | - | G.hfs2 | G | 191 | G.hfs2.07 |
Van-der-waals | C-term | V | 458 | - | G.hfs2 | G | 191 | G.hfs2.07 |
Polar | C-term | E | 453 | - | G.h1ha | A | 68 | G.h1ha.02 |
Van-der-waals | C-term | E | 453 | - | G.h1ha | A | 68 | G.h1ha.02 |
Polar | C-term | S | 457 | - | G.S2 | N | 193 | G.S2.02 |
Hydrophobic | C-term | S | 457 | - | G.S2 | N | 193 | G.S2.02 |
Van-der-waals | C-term | S | 457 | - | G.S2 | N | 193 | G.S2.02 |
Polar | C-term | L | 443 | - | G.HN | K | 37 | G.HN.52 |
Hydrophobic | C-term | L | 443 | - | G.HN | K | 37 | G.HN.52 |
Van-der-waals | C-term | L | 443 | - | G.HN | K | 37 | G.HN.52 |
Hydrophobic | C-term | S | 407 | - | G.H2 | R | 216 | G.H2.04 |
Hydrophobic | TM3 | A | 155 | 3x53 | G.H5 | Y | 367 | G.H5.19 |
Van-der-waals | TM3 | A | 155 | 3x53 | G.H5 | Y | 367 | G.H5.19 |
Ionic | C-term | E | 453 | - | G.H1 | R | 63 | G.H1.09 |
Polar | C-term | E | 453 | - | G.H1 | R | 63 | G.H1.09 |
Hydrophobic | C-term | E | 453 | - | G.H1 | R | 63 | G.H1.09 |
Van-der-waals | C-term | E | 453 | - | G.H1 | R | 63 | G.H1.09 |
Hydrophobic | ICL3 | R | 297 | - | G.h4s6 | T | 321 | G.h4s6.03 |
Van-der-waals | ICL3 | R | 297 | - | G.h4s6 | T | 321 | G.h4s6.03 |
Polar | TM5 | Q | 244 | 5x68 | G.H5 | R | 360 | G.H5.12 |
Hydrophobic | TM5 | Q | 244 | 5x68 | G.H5 | R | 360 | G.H5.12 |
Van-der-waals | TM5 | Q | 244 | 5x68 | G.H5 | R | 360 | G.H5.12 |
Polar | TM3 | D | 151 | 3x49 | G.H5 | Y | 367 | G.H5.19 |
Hydrophobic | C-term | Q | 397 | - | G.H3 | P | 265 | G.H3.16 |
Van-der-waals | C-term | Q | 397 | - | G.H3 | P | 265 | G.H3.16 |
Van-der-waals | C-term | I | 455 | - | G.S2 | E | 194 | G.S2.03 |
Hydrophobic | TM3 | I | 156 | 3x54 | G.H5 | L | 368 | G.H5.20 |
Hydrophobic | C-term | L | 406 | - | G.h2s4 | F | 223 | G.h2s4.01 |
Van-der-waals | C-term | L | 406 | - | G.h2s4 | F | 223 | G.h2s4.01 |
Hydrophobic | ICL2 | R | 164 | 34x55 | G.S3 | T | 202 | G.S3.01 |
Van-der-waals | ICL2 | R | 164 | 34x55 | G.S3 | T | 202 | G.S3.01 |
Polar | C-term | L | 406 | - | G.H2 | R | 216 | G.H2.04 |
Hydrophobic | C-term | L | 406 | - | G.H2 | R | 216 | G.H2.04 |
Van-der-waals | C-term | L | 406 | - | G.H2 | R | 216 | G.H2.04 |
Hydrophobic | C-term | L | 441 | - | G.HN | L | 33 | G.HN.48 |
Van-der-waals | C-term | L | 441 | - | G.HN | L | 33 | G.HN.48 |
Hydrophobic | TM6 | V | 312 | 6x36 | G.H5 | L | 373 | G.H5.25 |
Van-der-waals | TM6 | V | 312 | 6x36 | G.H5 | L | 373 | G.H5.25 |
Hydrophobic | ICL2 | I | 160 | 34x51 | G.H5 | V | 359 | G.H5.11 |
Hydrophobic | ICL2 | S | 163 | 34x54 | G.H5 | V | 363 | G.H5.15 |
Hydrophobic | C-term | L | 406 | - | G.H3 | T | 260 | G.H3.11 |
Polar | TM7 | T | 369 | 7x54 | G.H5 | N | 372 | G.H5.24 |
Hydrophobic | ICL2 | I | 160 | 34x51 | G.S1 | L | 43 | G.S1.02 |
Hydrophobic | ICL2 | P | 159 | 34x50 | G.H5 | R | 360 | G.H5.12 |
Polar | C-term | P | 444 | - | G.HN | K | 37 | G.HN.52 |
Hydrophobic | C-term | P | 444 | - | G.HN | K | 37 | G.HN.52 |
Van-der-waals | C-term | P | 444 | - | G.HN | K | 37 | G.HN.52 |
Polar | C-term | S | 456 | - | G.S2 | E | 194 | G.S2.03 |
Van-der-waals | C-term | S | 456 | - | G.S2 | E | 194 | G.S2.03 |
Ionic | ICL3 | R | 297 | - | G.h4s6 | D | 325 | G.h4s6.07 |
Polar | ICL3 | R | 297 | - | G.h4s6 | D | 325 | G.h4s6.07 |
Hydrophobic | ICL3 | R | 294 | - | G.H4 | R | 310 | G.H4.09 |
Van-der-waals | ICL3 | R | 294 | - | G.H4 | R | 310 | G.H4.09 |
Hydrophobic | C-term | V | 451 | - | G.S2 | S | 198 | G.S2.07 |
Hydrophobic | TM7 | F | 371 | 7x56 | G.H5 | N | 372 | G.H5.24 |
Van-der-waals | TM7 | F | 371 | 7x56 | G.H5 | N | 372 | G.H5.24 |
Polar | C-term | E | 439 | - | G.HN | M | 1 | G.HN.01 |
Hydrophobic | C-term | E | 439 | - | G.HN | M | 1 | G.HN.01 |
Van-der-waals | C-term | E | 439 | - | G.HN | M | 1 | G.HN.01 |
Polar | TM6 | A | 309 | 6x33 | G.H5 | L | 373 | G.H5.25 |
Hydrophobic | TM6 | A | 309 | 6x33 | G.H5 | L | 373 | G.H5.25 |
Polar | C-term | R | 454 | - | G.S2 | C | 196 | G.S2.05 |
Hydrophobic | C-term | R | 454 | - | G.S2 | C | 196 | G.S2.05 |
Van-der-waals | C-term | R | 454 | - | G.S2 | C | 196 | G.S2.05 |
Hydrophobic | ICL2 | I | 160 | 34x51 | G.H5 | V | 363 | G.H5.15 |
Polar | C-term | E | 439 | - | G.HN | A | 2 | G.HN.02 |
Hydrophobic | C-term | E | 439 | - | G.HN | A | 2 | G.HN.02 |
Van-der-waals | C-term | E | 439 | - | G.HN | A | 2 | G.HN.02 |
Hydrophobic | C-term | L | 441 | - | G.HN | K | 36 | G.HN.51 |
Van-der-waals | C-term | L | 441 | - | G.HN | K | 36 | G.HN.51 |
Polar | TM2 | N | 86 | 2x37 | G.H5 | E | 370 | G.H5.22 |
Hydrophobic | TM2 | N | 86 | 2x37 | G.H5 | E | 370 | G.H5.22 |
Van-der-waals | TM2 | N | 86 | 2x37 | G.H5 | E | 370 | G.H5.22 |
Polar | TM7 | Y | 368 | 7x53 | G.H5 | N | 372 | G.H5.24 |
Van-der-waals | TM7 | Y | 368 | 7x53 | G.H5 | N | 372 | G.H5.24 |
Hydrophobic | C-term | L | 406 | - | G.H3 | I | 261 | G.H3.12 |
Van-der-waals | C-term | S | 456 | - | G.S2 | N | 193 | G.S2.02 |
Hydrophobic | H8 | K | 373 | 8x48 | G.h4s6 | R | 335 | G.h4s6.17 |
Hydrophobic | ICL2 | R | 164 | 34x55 | G.S1 | E | 42 | G.S1.01 |
Van-der-waals | ICL2 | R | 164 | 34x55 | G.S1 | E | 42 | G.S1.01 |
Hydrophobic | ICL2 | I | 160 | 34x51 | G.H5 | R | 360 | G.H5.12 |
Polar | TM6 | K | 308 | 6x32 | G.H5 | L | 374 | G.H5.26 |
Hydrophobic | TM6 | K | 308 | 6x32 | G.H5 | L | 374 | G.H5.26 |
Van-der-waals | TM6 | K | 308 | 6x32 | G.H5 | L | 374 | G.H5.26 |
Hydrophobic | C-term | L | 406 | - | G.H2 | W | 219 | G.H2.07 |
Hydrophobic | TM6 | A | 302 | 6x26 | G.h4s6 | R | 338 | G.h4s6.20 |
Van-der-waals | TM6 | A | 302 | 6x26 | G.h4s6 | R | 338 | G.h4s6.20 |
Polar | TM3 | R | 152 | 3x50 | G.H5 | I | 371 | G.H5.23 |
Hydrophobic | TM3 | R | 152 | 3x50 | G.H5 | I | 371 | G.H5.23 |
Hydrophobic | C-term | E | 453 | - | G.S2 | F | 197 | G.S2.06 |
Polar | C-term | V | 458 | - | G.S2 | N | 193 | G.S2.02 |
Hydrophobic | ICL2 | P | 159 | 34x50 | G.H5 | V | 363 | G.H5.15 |
Van-der-waals | ICL2 | P | 159 | 34x50 | G.H5 | V | 363 | G.H5.15 |
Hydrophobic | ICL2 | I | 160 | 34x51 | G.S3 | T | 202 | G.S3.01 |
Van-der-waals | ICL2 | I | 160 | 34x51 | G.S3 | T | 202 | G.S3.01 |
Hydrophobic | C-term | I | 455 | - | G.S2 | Y | 195 | G.S2.04 |
Van-der-waals | C-term | I | 455 | - | G.S2 | Y | 195 | G.S2.04 |
Hydrophobic | TM3 | I | 156 | 3x54 | G.H5 | L | 364 | G.H5.16 |
Hydrophobic | TM6 | N | 305 | 6x29 | G.H5 | L | 374 | G.H5.26 |
Van-der-waals | TM6 | N | 305 | 6x29 | G.H5 | L | 374 | G.H5.26 |
Hydrophobic | ICL2 | I | 160 | 34x51 | G.H5 | F | 356 | G.H5.08 |
Van-der-waals | ICL2 | I | 160 | 34x51 | G.H5 | F | 356 | G.H5.08 |
Polar | ICL3 | G | 298 | - | G.S6 | L | 339 | G.S6.01 |
Hydrophobic | ICL3 | G | 298 | - | G.S6 | L | 339 | G.S6.01 |
Van-der-waals | ICL3 | G | 298 | - | G.S6 | L | 339 | G.S6.01 |
Hydrophobic | C-term | A | 405 | - | G.H3 | T | 260 | G.H3.11 |
Hydrophobic | C-term | L | 406 | - | G.H3 | L | 257 | G.H3.08 |
Hydrophobic | C-term | A | 402 | - | G.H2 | I | 220 | G.H2.08 |
Hydrophobic | TM2 | T | 88 | 2x39 | G.H5 | I | 371 | G.H5.23 |
Polar | C-term | Q | 397 | - | G.H3 | W | 266 | G.H3.17 |
Hydrophobic | C-term | Q | 397 | - | G.H3 | W | 266 | G.H3.17 |
Van-der-waals | C-term | Q | 397 | - | G.H3 | W | 266 | G.H3.17 |
Hydrophobic | ICL2 | R | 164 | 34x55 | G.S1 | L | 43 | G.S1.02 |
Van-der-waals | ICL2 | R | 164 | 34x55 | G.S1 | L | 43 | G.S1.02 |
Hydrophobic | C-term | A | 402 | - | G.H3 | W | 266 | G.H3.17 |
Van-der-waals | C-term | A | 402 | - | G.H3 | W | 266 | G.H3.17 |
Polar | TM2 | T | 88 | 2x39 | G.H5 | E | 370 | G.H5.22 |
Van-der-waals | TM2 | T | 88 | 2x39 | G.H5 | E | 370 | G.H5.22 |
Hydrophobic | C-term | S | 407 | - | G.H2 | K | 213 | G.H2.01 |
Hydrophobic | C-term | P | 399 | - | G.H2 | I | 220 | G.H2.08 |
Van-der-waals | C-term | P | 399 | - | G.H2 | I | 220 | G.H2.08 |
Hydrophobic | TM5 | Q | 244 | 5x68 | G.H5 | L | 364 | G.H5.16 |
Van-der-waals | TM5 | Q | 244 | 5x68 | G.H5 | L | 364 | G.H5.16 |
Polar | TM3 | R | 152 | 3x50 | G.H5 | Y | 367 | G.H5.19 |
Hydrophobic | TM3 | R | 152 | 3x50 | G.H5 | Y | 367 | G.H5.19 |
Van-der-waals | TM3 | R | 152 | 3x50 | G.H5 | Y | 367 | G.H5.19 |
Hydrophobic | C-term | P | 399 | - | G.H3 | W | 266 | G.H3.17 |
Hydrophobic | C-term | L | 406 | - | G.H3 | L | 264 | G.H3.15 |
Van-der-waals | TM6 | N | 305 | 6x29 | G.h4s6 | R | 338 | G.h4s6.20 |
Hydrophobic | C-term | S | 407 | - | G.H2 | K | 217 | G.H2.05 |
Polar | TM5 | Q | 244 | 5x68 | G.H5 | D | 361 | G.H5.13 |
Van-der-waals | TM5 | Q | 244 | 5x68 | G.H5 | D | 361 | G.H5.13 |
Hydrophobic | ICL2 | P | 159 | 34x50 | G.H5 | L | 364 | G.H5.16 |
Polar | ICL2 | R | 164 | 34x55 | G.S3 | N | 203 | G.S3.02 |
Van-der-waals | ICL2 | R | 164 | 34x55 | G.S3 | N | 203 | G.S3.02 |
Polar | ICL2 | R | 164 | 34x55 | G.hns1 | G | 41 | G.hns1.03 |
Hydrophobic | ICL2 | R | 164 | 34x55 | G.hns1 | G | 41 | G.hns1.03 |
Van-der-waals | ICL2 | R | 164 | 34x55 | G.hns1 | G | 41 | G.hns1.03 |
Polar | H8 | K | 373 | 8x48 | G.h4s6 | K | 331 | G.h4s6.13 |
Hydrophobic | TM2 | T | 88 | 2x39 | G.H5 | Y | 367 | G.H5.19 |
Hydrophobic | C-term | A | 402 | - | G.H3 | L | 264 | G.H3.15 |
Van-der-waals | C-term | A | 402 | - | G.H3 | L | 264 | G.H3.15 |
Hydrophobic | TM6 | A | 309 | 6x33 | G.H5 | L | 368 | G.H5.20 |
Hydrophobic | TM6 | L | 313 | 6x37 | G.H5 | L | 373 | G.H5.25 |
Polar | H8 | N | 372 | 8x47 | G.H5 | N | 372 | G.H5.24 |
Hydrophobic | H8 | N | 372 | 8x47 | G.H5 | N | 372 | G.H5.24 |
Van-der-waals | H8 | N | 372 | 8x47 | G.H5 | N | 372 | G.H5.24 |
Polar | C-term | V | 458 | - | G.S2 | I | 192 | G.S2.01 |
Van-der-waals | C-term | V | 458 | - | G.S2 | I | 192 | G.S2.01 |
Aromatic | ICL2 | H | 162 | 34x53 | G.H5 | Y | 367 | G.H5.19 |
Hydrophobic | ICL2 | H | 162 | 34x53 | G.H5 | Y | 367 | G.H5.19 |
Van-der-waals | ICL2 | H | 162 | 34x53 | G.H5 | Y | 367 | G.H5.19 |
Hydrophobic | C-term | A | 403 | - | G.H2 | K | 217 | G.H2.05 |
Hydrophobic | TM5 | L | 248 | 5x72 | G.H5 | K | 357 | G.H5.09 |
Van-der-waals | TM5 | L | 248 | 5x72 | G.H5 | K | 357 | G.H5.09 |