G12 - 5-HT5A receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 81.2

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 16.7


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM5 I 223 5x61 G.H5 I 378 G.H5.23
Hydrophobic ICL2 H 146 34x50 G.H5 I 370 G.H5.15
Polar TM5 R 230 5x68 G.H5 K 367 G.H5.12
Van-der-waals TM5 R 230 5x68 G.H5 Q 372 G.H5.17
Hydrophobic ICL2 T 150 34x54 G.hns1 R 55 G.hns1.02
Hydrophobic ICL3 P 241 - G.h4s6 R 342 G.h4s6.11
Van-der-waals ICL3 P 241 - G.h4s6 R 342 G.h4s6.11
Polar TM4 T 153 4x37 G.hns1 R 56 G.hns1.03
Van-der-waals TM4 T 153 4x37 G.hns1 R 56 G.hns1.03
Hydrophobic TM5 R 230 5x68 G.H5 L 375 G.H5.20
Van-der-waals TM5 R 230 5x68 G.H5 L 375 G.H5.20
Hydrophobic TM5 N 237 5x75 G.H5 F 361 G.H5.06
Hydrophobic TM6 M 286 6x36 G.H5 L 380 G.H5.25
Van-der-waals TM6 M 286 6x36 G.H5 L 380 G.H5.25
Van-der-waals TM7 I 337 7x52 G.H5 L 380 G.H5.25
Hydrophobic ICL2 M 147 34x51 G.H5 K 367 G.H5.12
Hydrophobic ICL3 P 241 - G.h4s6 K 344 G.h4s6.19
Hydrophobic TM3 R 139 3x50 G.H5 I 378 G.H5.23
Van-der-waals TM3 R 139 3x50 G.H5 I 378 G.H5.23
Hydrophobic TM5 S 238 5x76 G.S6 H 348 G.S6.03
Polar TM5 N 237 5x75 G.S6 H 348 G.S6.03
Hydrophobic TM5 N 237 5x75 G.S6 H 348 G.S6.03
Van-der-waals TM5 N 237 5x75 G.S6 H 348 G.S6.03
Hydrophobic ICL2 M 147 34x51 G.S1 V 58 G.S1.02
Hydrophobic TM3 I 143 3x54 G.H5 L 371 G.H5.16
Van-der-waals TM3 I 143 3x54 G.H5 L 371 G.H5.16
Polar ICL3 V 239 - G.S6 L 346 G.S6.01
Van-der-waals ICL3 V 239 - G.S6 L 346 G.S6.01
Polar ICL3 V 239 - G.h4s6 R 339 G.h4s6.08
Polar ICL2 T 150 34x54 G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 T 150 34x54 G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 T 150 34x54 G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 M 147 34x51 G.H5 F 363 G.H5.08
Hydrophobic TM5 S 238 5x76 G.S6 L 346 G.S6.01
Van-der-waals TM5 S 238 5x76 G.S6 L 346 G.S6.01
Hydrophobic ICL3 V 239 - G.H4 V 332 G.H4.12
Van-der-waals ICL3 V 239 - G.H4 V 332 G.H4.12
Hydrophobic ICL3 P 241 - G.h4s6 P 345 G.h4s6.20
Polar TM4 L 151 4x35 G.hns1 R 55 G.hns1.02
Hydrophobic TM4 L 151 4x35 G.hns1 R 55 G.hns1.02
Van-der-waals TM4 L 151 4x35 G.hns1 R 55 G.hns1.02
Hydrophobic TM5 S 238 5x76 G.h4s6 P 345 G.h4s6.20
Van-der-waals TM5 N 237 5x75 G.S6 F 347 G.S6.02
Polar TM6 R 282 6x32 G.H5 L 380 G.H5.25
Hydrophobic TM5 A 227 5x65 G.H5 L 375 G.H5.20
Hydrophobic ICL2 M 147 34x51 G.S3 I 221 G.S3.01
Van-der-waals ICL2 M 147 34x51 G.S3 I 221 G.S3.01
Hydrophobic ICL2 M 147 34x51 G.S3 F 223 G.S3.03
Hydrophobic ICL2 M 147 34x51 G.H5 V 366 G.H5.11
Hydrophobic TM7 F 341 7x56 G.H5 L 380 G.H5.25
Van-der-waals TM7 F 341 7x56 G.H5 L 380 G.H5.25
Hydrophobic TM6 A 283 6x33 G.H5 M 379 G.H5.24
Van-der-waals TM6 A 283 6x33 G.H5 M 379 G.H5.24
Hydrophobic ICL2 M 147 34x51 G.H5 I 370 G.H5.15
Hydrophobic H8 N 342 8x47 G.H5 L 380 G.H5.25
Van-der-waals H8 N 342 8x47 G.H5 L 380 G.H5.25
Hydrophobic TM5 S 238 5x76 G.S6 F 347 G.S6.02
Hydrophobic ICL3 V 239 - G.H4 D 336 G.H4.16
Van-der-waals ICL3 V 239 - G.H4 D 336 G.H4.16
Polar TM3 S 142 3x53 G.H5 N 374 G.H5.19
Hydrophobic TM3 S 142 3x53 G.H5 N 374 G.H5.19
Van-der-waals TM3 S 142 3x53 G.H5 N 374 G.H5.19
Hydrophobic TM5 K 235 5x73 G.S6 F 347 G.S6.02
Hydrophobic TM6 R 282 6x32 G.H5 Q 381 G.H5.26
Van-der-waals TM6 R 282 6x32 G.H5 Q 381 G.H5.26
Polar ICL2 H 146 34x50 G.H5 K 367 G.H5.12
Hydrophobic ICL2 H 146 34x50 G.H5 K 367 G.H5.12
Van-der-waals ICL2 H 146 34x50 G.H5 K 367 G.H5.12
Hydrophobic TM3 I 143 3x54 G.H5 L 375 G.H5.20
Van-der-waals TM3 I 143 3x54 G.H5 L 375 G.H5.20
Ionic TM5 R 230 5x68 G.H5 D 368 G.H5.13
Polar TM5 R 230 5x68 G.H5 D 368 G.H5.13
Hydrophobic TM5 R 230 5x68 G.H5 D 368 G.H5.13
Van-der-waals TM5 R 230 5x68 G.H5 D 368 G.H5.13
Ionic TM5 K 235 5x73 G.H5 D 368 G.H5.13
Polar TM5 K 235 5x73 G.H5 D 368 G.H5.13
Hydrophobic TM5 K 235 5x73 G.H5 D 368 G.H5.13
Van-der-waals TM5 K 235 5x73 G.H5 D 368 G.H5.13
Polar TM5 N 237 5x75 G.S6 H 349 G.S6.04
Hydrophobic TM3 I 143 3x54 G.H5 I 378 G.H5.23
Van-der-waals TM3 I 143 3x54 G.H5 I 378 G.H5.23
Polar ICL3 V 239 - G.S6 H 348 G.S6.03
Hydrophobic ICL3 V 239 - G.S6 H 348 G.S6.03
Van-der-waals ICL3 V 239 - G.S6 H 348 G.S6.03
Ionic ICL3 E 244 - G.H4 R 337 G.H4.17
Polar ICL3 E 244 - G.H4 R 337 G.H4.17
Van-der-waals ICL3 E 244 - G.H4 R 337 G.H4.17
Polar ICL3 I 242 - G.h4s6 R 342 G.h4s6.11
Van-der-waals ICL3 I 242 - G.h4s6 R 342 G.h4s6.11
Hydrophobic H8 K 343 8x48 G.H5 Q 381 G.H5.26
Van-der-waals H8 K 343 8x48 G.H5 Q 381 G.H5.26
Hydrophobic ICL2 H 146 34x50 G.H5 L 371 G.H5.16
Van-der-waals ICL2 H 146 34x50 G.H5 L 371 G.H5.16
Polar TM5 R 230 5x68 G.H5 L 371 G.H5.16
Hydrophobic TM5 R 230 5x68 G.H5 L 371 G.H5.16
Van-der-waals TM5 R 230 5x68 G.H5 L 371 G.H5.16