Gz -
5-HT5A receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 79.9
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.5
iPTM Score: 0.3
PAE mean: 25.5
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | ICL3 | F | 268 | - | G.H4 | Q | 307 | G.H4.14 |
Hydrophobic | ICL2 | T | 150 | 34x54 | G.s2s3 | E | 194 | G.s2s3.02 |
Hydrophobic | TM3 | I | 135 | 3x46 | G.H5 | L | 354 | G.H5.25 |
Van-der-waals | TM3 | I | 135 | 3x46 | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | TM4 | L | 151 | 4x35 | G.H5 | I | 352 | G.H5.23 |
Polar | ICL3 | E | 244 | - | G.hgh4 | G | 293 | G.hgh4.07 |
Hydrophobic | ICL3 | E | 244 | - | G.hgh4 | G | 293 | G.hgh4.07 |
Van-der-waals | ICL3 | E | 244 | - | G.hgh4 | G | 293 | G.hgh4.07 |
Polar | ICL2 | H | 146 | 34x50 | G.s2s3 | K | 193 | G.s2s3.01 |
Hydrophobic | ICL2 | H | 146 | 34x50 | G.s2s3 | K | 193 | G.s2s3.01 |
Van-der-waals | ICL2 | H | 146 | 34x50 | G.s2s3 | K | 193 | G.s2s3.01 |
Polar | H8 | N | 342 | 8x47 | G.H5 | C | 355 | G.H5.26 |
Van-der-waals | H8 | N | 342 | 8x47 | G.H5 | C | 355 | G.H5.26 |
Polar | ICL3 | E | 244 | - | G.H4 | E | 299 | G.H4.05 |
Van-der-waals | ICL3 | E | 244 | - | G.H4 | E | 299 | G.H4.05 |
Polar | ICL2 | T | 150 | 34x54 | G.hns1 | R | 32 | G.hns1.03 |
Hydrophobic | ICL2 | T | 150 | 34x54 | G.hns1 | R | 32 | G.hns1.03 |
Van-der-waals | ICL2 | T | 150 | 34x54 | G.hns1 | R | 32 | G.hns1.03 |
Polar | TM2 | H | 76 | 2x40 | G.H5 | Y | 351 | G.H5.22 |
Polar | TM4 | R | 154 | 4x38 | G.H5 | N | 348 | G.H5.19 |
Polar | TM3 | R | 139 | 3x50 | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | TM3 | R | 139 | 3x50 | G.H5 | L | 354 | G.H5.25 |
Van-der-waals | TM3 | R | 139 | 3x50 | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | ICL3 | E | 244 | - | G.hgh4 | Y | 291 | G.hgh4.05 |
Van-der-waals | ICL3 | E | 244 | - | G.hgh4 | Y | 291 | G.hgh4.05 |
Ionic | ICL2 | H | 146 | 34x50 | G.H5 | D | 342 | G.H5.13 |
Polar | ICL2 | H | 146 | 34x50 | G.H5 | D | 342 | G.H5.13 |
Hydrophobic | ICL2 | H | 146 | 34x50 | G.H5 | D | 342 | G.H5.13 |
Van-der-waals | ICL2 | H | 146 | 34x50 | G.H5 | D | 342 | G.H5.13 |
Polar | ICL3 | T | 267 | - | G.H4 | E | 299 | G.H4.05 |
Polar | ICL3 | S | 243 | - | G.H4 | E | 299 | G.H4.05 |
Hydrophobic | ICL3 | S | 243 | - | G.H4 | E | 299 | G.H4.05 |
Van-der-waals | ICL3 | S | 243 | - | G.H4 | E | 299 | G.H4.05 |
Polar | ICL3 | A | 245 | - | G.H4 | E | 299 | G.H4.05 |
Hydrophobic | ICL3 | A | 245 | - | G.H4 | E | 299 | G.H4.05 |
Van-der-waals | ICL3 | A | 245 | - | G.H4 | E | 299 | G.H4.05 |
Polar | ICL3 | Q | 269 | - | G.H4 | R | 306 | G.H4.13 |
Van-der-waals | ICL3 | Q | 269 | - | G.H4 | R | 306 | G.H4.13 |
Hydrophobic | ICL3 | A | 245 | - | G.H4 | Y | 303 | G.H4.10 |
Van-der-waals | ICL3 | A | 245 | - | G.H4 | Y | 303 | G.H4.10 |
Hydrophobic | ICL2 | M | 147 | 34x51 | G.s2s3 | K | 193 | G.s2s3.01 |
Van-der-waals | ICL2 | M | 147 | 34x51 | G.s2s3 | K | 193 | G.s2s3.01 |
Hydrophobic | TM3 | S | 142 | 3x53 | G.H5 | L | 349 | G.H5.20 |
Van-der-waals | TM3 | S | 142 | 3x53 | G.H5 | L | 349 | G.H5.20 |
Hydrophobic | H8 | N | 342 | 8x47 | G.H5 | G | 353 | G.H5.24 |
Polar | ICL3 | S | 243 | - | G.hgh4 | Q | 294 | G.hgh4.08 |
Hydrophobic | ICL3 | S | 243 | - | G.hgh4 | Q | 294 | G.hgh4.08 |
Van-der-waals | ICL3 | S | 243 | - | G.hgh4 | Q | 294 | G.hgh4.08 |
Polar | ICL3 | A | 245 | - | G.hgh4 | Y | 291 | G.hgh4.05 |
Hydrophobic | ICL3 | A | 245 | - | G.hgh4 | Y | 291 | G.hgh4.05 |
Van-der-waals | ICL3 | A | 245 | - | G.hgh4 | Y | 291 | G.hgh4.05 |
Polar | ICL3 | T | 267 | - | G.hgh4 | K | 292 | G.hgh4.06 |
Hydrophobic | ICL3 | S | 240 | - | G.H4 | E | 298 | G.H4.04 |
Van-der-waals | ICL3 | S | 240 | - | G.H4 | E | 298 | G.H4.04 |
Hydrophobic | ICL2 | E | 148 | 34x52 | G.s2s3 | E | 194 | G.s2s3.02 |
Van-der-waals | ICL2 | E | 148 | 34x52 | G.s2s3 | E | 194 | G.s2s3.02 |
Polar | ICL3 | E | 244 | - | G.H4 | N | 295 | G.H4.01 |
Hydrophobic | ICL3 | E | 244 | - | G.H4 | N | 295 | G.H4.01 |
Van-der-waals | ICL3 | E | 244 | - | G.H4 | N | 295 | G.H4.01 |
Polar | H8 | K | 343 | 8x48 | G.h4s6 | E | 316 | G.h4s6.09 |
Van-der-waals | H8 | K | 343 | 8x48 | G.h4s6 | E | 316 | G.h4s6.09 |
Hydrophobic | ICL3 | P | 241 | - | G.H4 | E | 298 | G.H4.04 |
Van-der-waals | ICL3 | P | 241 | - | G.H4 | E | 298 | G.H4.04 |
Hydrophobic | ICL2 | M | 147 | 34x51 | G.H5 | T | 341 | G.H5.12 |
Van-der-waals | ICL2 | M | 147 | 34x51 | G.H5 | T | 341 | G.H5.12 |
Polar | ICL3 | I | 242 | - | G.H4 | T | 296 | G.H4.02 |
Hydrophobic | ICL3 | I | 242 | - | G.H4 | T | 296 | G.H4.02 |
Van-der-waals | ICL3 | I | 242 | - | G.H4 | T | 296 | G.H4.02 |
Hydrophobic | ICL3 | S | 243 | - | G.hgh4 | G | 293 | G.hgh4.07 |
Van-der-waals | ICL3 | S | 243 | - | G.hgh4 | G | 293 | G.hgh4.07 |
Aromatic | ICL3 | F | 268 | - | G.H4 | Y | 303 | G.H4.10 |
Hydrophobic | ICL3 | F | 268 | - | G.H4 | Y | 303 | G.H4.10 |
Van-der-waals | ICL3 | F | 268 | - | G.H4 | Y | 303 | G.H4.10 |
Hydrophobic | ICL2 | M | 147 | 34x51 | G.S2 | F | 192 | G.S2.08 |
Van-der-waals | ICL2 | M | 147 | 34x51 | G.S2 | F | 192 | G.S2.08 |
Polar | TM4 | R | 152 | 4x36 | G.HN | Q | 28 | G.HN.52 |
Hydrophobic | TM4 | R | 152 | 4x36 | G.HN | Q | 28 | G.HN.52 |
Van-der-waals | TM4 | R | 152 | 4x36 | G.HN | Q | 28 | G.HN.52 |
Hydrophobic | TM2 | P | 75 | 2x39 | G.H5 | L | 354 | G.H5.25 |
Van-der-waals | TM2 | P | 75 | 2x39 | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | TM4 | L | 151 | 4x35 | G.hns1 | R | 31 | G.hns1.02 |
Van-der-waals | TM4 | L | 151 | 4x35 | G.hns1 | R | 31 | G.hns1.02 |
Hydrophobic | ICL2 | M | 147 | 34x51 | G.s2s3 | E | 194 | G.s2s3.02 |
Hydrophobic | ICL2 | M | 147 | 34x51 | G.S3 | L | 195 | G.S3.01 |
Van-der-waals | ICL2 | M | 147 | 34x51 | G.S3 | L | 195 | G.S3.01 |
Polar | ICL3 | I | 242 | - | G.H4 | E | 299 | G.H4.05 |
Hydrophobic | ICL3 | I | 242 | - | G.H4 | E | 299 | G.H4.05 |
Van-der-waals | ICL3 | I | 242 | - | G.H4 | E | 299 | G.H4.05 |
Hydrophobic | H8 | Y | 345 | 8x50 | G.H5 | G | 353 | G.H5.24 |
Hydrophobic | TM2 | V | 74 | 2x38 | G.H5 | I | 352 | G.H5.23 |
Van-der-waals | TM2 | V | 74 | 2x38 | G.H5 | I | 352 | G.H5.23 |
Polar | H8 | N | 342 | 8x47 | G.H5 | K | 350 | G.H5.21 |
Van-der-waals | H8 | N | 342 | 8x47 | G.H5 | K | 350 | G.H5.21 |
Hydrophobic | TM4 | R | 152 | 4x36 | G.hns1 | R | 32 | G.hns1.03 |
Van-der-waals | TM4 | R | 152 | 4x36 | G.hns1 | R | 32 | G.hns1.03 |
Hydrophobic | ICL2 | M | 147 | 34x51 | G.H5 | I | 345 | G.H5.16 |
Van-der-waals | ICL2 | M | 147 | 34x51 | G.H5 | I | 345 | G.H5.16 |
Polar | TM4 | T | 153 | 4x37 | G.hns1 | R | 32 | G.hns1.03 |
Van-der-waals | TM4 | T | 153 | 4x37 | G.hns1 | R | 32 | G.hns1.03 |
Hydrophobic | TM3 | D | 138 | 3x49 | G.H5 | L | 354 | G.H5.25 |
Van-der-waals | TM3 | D | 138 | 3x49 | G.H5 | L | 354 | G.H5.25 |
Ionic | TM5 | R | 230 | 5x68 | G.H5 | D | 342 | G.H5.13 |
Polar | TM5 | R | 230 | 5x68 | G.H5 | D | 342 | G.H5.13 |
Hydrophobic | TM5 | R | 230 | 5x68 | G.H5 | D | 342 | G.H5.13 |
Van-der-waals | TM5 | R | 230 | 5x68 | G.H5 | D | 342 | G.H5.13 |
Hydrophobic | TM2 | H | 76 | 2x40 | G.H5 | G | 353 | G.H5.24 |
Polar | H8 | N | 344 | 8x49 | G.H5 | Y | 351 | G.H5.22 |
Hydrophobic | H8 | N | 344 | 8x49 | G.H5 | Y | 351 | G.H5.22 |
Van-der-waals | H8 | N | 344 | 8x49 | G.H5 | Y | 351 | G.H5.22 |
Hydrophobic | ICL3 | V | 239 | - | G.H4 | E | 298 | G.H4.04 |
Van-der-waals | ICL3 | V | 239 | - | G.H4 | E | 298 | G.H4.04 |
Hydrophobic | ICL2 | H | 146 | 34x50 | G.H5 | I | 345 | G.H5.16 |
Hydrophobic | TM4 | R | 154 | 4x38 | G.H5 | L | 349 | G.H5.20 |
Van-der-waals | TM4 | R | 154 | 4x38 | G.H5 | L | 349 | G.H5.20 |
Hydrophobic | ICL3 | P | 241 | - | G.H4 | E | 299 | G.H4.05 |
Van-der-waals | ICL3 | P | 241 | - | G.H4 | E | 299 | G.H4.05 |
Hydrophobic | ICL3 | F | 268 | - | G.H4 | V | 302 | G.H4.08 |
Polar | ICL3 | E | 244 | - | G.hgh4 | K | 292 | G.hgh4.06 |
Hydrophobic | ICL3 | E | 244 | - | G.hgh4 | K | 292 | G.hgh4.06 |
Van-der-waals | ICL3 | E | 244 | - | G.hgh4 | K | 292 | G.hgh4.06 |
Polar | TM2 | P | 75 | 2x39 | G.H5 | I | 352 | G.H5.23 |
Hydrophobic | TM2 | P | 75 | 2x39 | G.H5 | I | 352 | G.H5.23 |
Van-der-waals | TM2 | P | 75 | 2x39 | G.H5 | I | 352 | G.H5.23 |
Polar | ICL3 | F | 268 | - | G.H4 | R | 306 | G.H4.13 |
Hydrophobic | ICL3 | F | 268 | - | G.H4 | R | 306 | G.H4.13 |
Van-der-waals | ICL3 | F | 268 | - | G.H4 | R | 306 | G.H4.13 |
Polar | TM2 | H | 76 | 2x40 | G.H5 | I | 352 | G.H5.23 |
Hydrophobic | TM2 | H | 76 | 2x40 | G.H5 | I | 352 | G.H5.23 |
Van-der-waals | TM2 | H | 76 | 2x40 | G.H5 | I | 352 | G.H5.23 |
Ionic | TM6 | K | 279 | 6x29 | G.h4s6 | E | 319 | G.h4s6.12 |
Polar | TM6 | K | 279 | 6x29 | G.h4s6 | E | 319 | G.h4s6.12 |
Van-der-waals | TM6 | K | 279 | 6x29 | G.h4s6 | E | 319 | G.h4s6.12 |
Hydrophobic | ICL3 | A | 245 | - | G.H4 | A | 300 | G.H4.06 |
Van-der-waals | ICL3 | A | 245 | - | G.H4 | A | 300 | G.H4.06 |
Polar | ICL3 | E | 244 | - | G.hgh4 | Q | 294 | G.hgh4.08 |
Hydrophobic | ICL3 | E | 244 | - | G.hgh4 | Q | 294 | G.hgh4.08 |
Van-der-waals | ICL3 | E | 244 | - | G.hgh4 | Q | 294 | G.hgh4.08 |
Hydrophobic | ICL3 | I | 242 | - | G.H4 | E | 298 | G.H4.04 |
Van-der-waals | ICL3 | I | 242 | - | G.H4 | E | 298 | G.H4.04 |
Hydrophobic | TM2 | R | 73 | 2x37 | G.H5 | I | 352 | G.H5.23 |
Van-der-waals | TM2 | R | 73 | 2x37 | G.H5 | I | 352 | G.H5.23 |
Hydrophobic | ICL2 | T | 150 | 34x54 | G.S3 | L | 195 | G.S3.01 |