G15 -
5-HT7 receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 75.2
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 12.8
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | ICL2 | L | 188 | 34x51 | G.H5 | V | 359 | G.H5.11 |
Hydrophobic | TM3 | G | 183 | 3x53 | G.H5 | Y | 367 | G.H5.19 |
Polar | TM6 | T | 328 | 6x36 | G.H5 | N | 372 | G.H5.24 |
Hydrophobic | TM5 | F | 275 | 5x74 | G.h4s6 | Y | 320 | G.h4s6.02 |
Hydrophobic | TM6 | K | 324 | 6x32 | G.H5 | L | 373 | G.H5.25 |
Hydrophobic | ICL2 | L | 188 | 34x51 | G.H5 | R | 360 | G.H5.12 |
Hydrophobic | C-term | L | 432 | - | G.H2 | K | 217 | G.H2.05 |
Van-der-waals | C-term | L | 432 | - | G.H2 | K | 217 | G.H2.05 |
Hydrophobic | C-term | F | 430 | - | G.H2 | K | 213 | G.H2.01 |
Hydrophobic | TM3 | I | 184 | 3x54 | G.H5 | L | 364 | G.H5.16 |
Van-der-waals | TM3 | I | 184 | 3x54 | G.H5 | L | 364 | G.H5.16 |
Hydrophobic | TM6 | L | 329 | 6x37 | G.H5 | L | 373 | G.H5.25 |
Hydrophobic | TM3 | I | 184 | 3x54 | G.H5 | L | 368 | G.H5.20 |
Van-der-waals | TM6 | K | 324 | 6x32 | G.h4s6 | R | 335 | G.h4s6.17 |
Ionic | TM5 | K | 272 | 5x71 | G.H5 | D | 361 | G.H5.13 |
Polar | TM5 | K | 272 | 5x71 | G.H5 | D | 361 | G.H5.13 |
Hydrophobic | TM5 | K | 272 | 5x71 | G.H5 | D | 361 | G.H5.13 |
Van-der-waals | TM5 | K | 272 | 5x71 | G.H5 | D | 361 | G.H5.13 |
Polar | TM6 | K | 324 | 6x32 | G.H5 | L | 374 | G.H5.26 |
Hydrophobic | TM6 | K | 324 | 6x32 | G.H5 | L | 374 | G.H5.26 |
Van-der-waals | TM6 | K | 324 | 6x32 | G.H5 | L | 374 | G.H5.26 |
Hydrophobic | ICL2 | P | 187 | 34x50 | G.H5 | R | 360 | G.H5.12 |
Hydrophobic | TM3 | I | 184 | 3x54 | G.H5 | Y | 367 | G.H5.19 |
Van-der-waals | TM3 | I | 184 | 3x54 | G.H5 | Y | 367 | G.H5.19 |
Ionic | C-term | E | 417 | - | G.h3s5 | K | 268 | G.h3s5.01 |
Hydrophobic | C-term | W | 452 | - | H.HA | E | 74 | H.HA.03 |
Van-der-waals | C-term | W | 452 | - | H.HA | E | 74 | H.HA.03 |
Hydrophobic | ICL2 | L | 188 | 34x51 | G.S3 | T | 202 | G.S3.01 |
Hydrophobic | C-term | W | 452 | - | G.h1ha | G | 67 | G.h1ha.01 |
Hydrophobic | TM5 | S | 269 | 5x68 | G.H5 | L | 364 | G.H5.16 |
Hydrophobic | ICL3 | F | 278 | - | G.H4 | D | 314 | G.H4.13 |
Van-der-waals | ICL3 | F | 278 | - | G.H4 | D | 314 | G.H4.13 |
Hydrophobic | TM3 | I | 184 | 3x54 | G.H5 | I | 371 | G.H5.23 |
Polar | TM3 | D | 179 | 3x49 | G.H5 | Y | 367 | G.H5.19 |
Polar | H8 | R | 389 | 8x48 | G.H5 | E | 370 | G.H5.22 |
Hydrophobic | TM5 | H | 273 | 5x72 | G.S6 | F | 340 | G.S6.02 |
Van-der-waals | TM5 | H | 273 | 5x72 | G.S6 | F | 340 | G.S6.02 |
Polar | C-term | V | 431 | - | G.H2 | K | 217 | G.H2.05 |
Hydrophobic | C-term | V | 431 | - | G.H2 | K | 217 | G.H2.05 |
Van-der-waals | C-term | V | 431 | - | G.H2 | K | 217 | G.H2.05 |
Hydrophobic | C-term | W | 452 | - | G.h1ha | A | 68 | G.h1ha.02 |
Van-der-waals | C-term | W | 452 | - | G.h1ha | A | 68 | G.h1ha.02 |
Hydrophobic | C-term | L | 454 | - | G.h1ha | G | 67 | G.h1ha.01 |
Hydrophobic | ICL2 | L | 188 | 34x51 | G.S1 | L | 43 | G.S1.02 |
Van-der-waals | ICL2 | L | 188 | 34x51 | G.S1 | L | 43 | G.S1.02 |
Ionic | H8 | R | 389 | 8x48 | G.H5 | D | 369 | G.H5.21 |
Polar | H8 | R | 389 | 8x48 | G.H5 | D | 369 | G.H5.21 |
Hydrophobic | H8 | R | 389 | 8x48 | G.H5 | D | 369 | G.H5.21 |
Van-der-waals | H8 | R | 389 | 8x48 | G.H5 | D | 369 | G.H5.21 |
Hydrophobic | ICL2 | L | 188 | 34x51 | G.H5 | F | 356 | G.H5.08 |
Van-der-waals | ICL2 | L | 188 | 34x51 | G.H5 | F | 356 | G.H5.08 |
Hydrophobic | C-term | A | 418 | - | G.H3 | P | 265 | G.H3.16 |
Van-der-waals | C-term | A | 418 | - | G.H3 | P | 265 | G.H3.16 |
Polar | TM7 | F | 387 | 7x56 | G.H5 | N | 372 | G.H5.24 |
Hydrophobic | TM7 | F | 387 | 7x56 | G.H5 | N | 372 | G.H5.24 |
Van-der-waals | TM7 | F | 387 | 7x56 | G.H5 | N | 372 | G.H5.24 |
Hydrophobic | TM3 | R | 180 | 3x50 | G.H5 | Y | 367 | G.H5.19 |
Van-der-waals | TM3 | R | 180 | 3x50 | G.H5 | Y | 367 | G.H5.19 |
Van-der-waals | TM7 | F | 387 | 7x56 | G.H5 | I | 371 | G.H5.23 |
Polar | TM5 | H | 273 | 5x72 | G.h4s6 | R | 338 | G.h4s6.20 |
Aromatic | TM5 | H | 273 | 5x72 | G.h4s6 | R | 338 | G.h4s6.20 |
Hydrophobic | TM5 | H | 273 | 5x72 | G.h4s6 | R | 338 | G.h4s6.20 |
Van-der-waals | TM5 | H | 273 | 5x72 | G.h4s6 | R | 338 | G.h4s6.20 |
Hydrophobic | ICL2 | P | 187 | 34x50 | G.H5 | L | 364 | G.H5.16 |
Hydrophobic | TM5 | I | 262 | 5x61 | G.H5 | L | 373 | G.H5.25 |
Van-der-waals | TM5 | I | 262 | 5x61 | G.H5 | L | 373 | G.H5.25 |
Hydrophobic | C-term | L | 454 | - | G.S2 | S | 198 | G.S2.07 |
Van-der-waals | C-term | L | 454 | - | G.S2 | S | 198 | G.S2.07 |
Hydrophobic | TM5 | S | 269 | 5x68 | G.H5 | L | 368 | G.H5.20 |
Hydrophobic | ICL3 | F | 278 | - | G.H4 | T | 317 | G.H4.16 |
Van-der-waals | ICL3 | F | 278 | - | G.H4 | T | 317 | G.H4.16 |
Hydrophobic | ICL2 | V | 192 | 34x55 | G.hns1 | G | 41 | G.hns1.03 |
Van-der-waals | ICL2 | V | 192 | 34x55 | G.hns1 | G | 41 | G.hns1.03 |
Hydrophobic | C-term | L | 454 | - | G.H1 | H | 66 | G.H1.12 |
Van-der-waals | C-term | L | 454 | - | G.H1 | H | 66 | G.H1.12 |
Hydrophobic | ICL2 | P | 187 | 34x50 | G.H5 | V | 363 | G.H5.15 |
Van-der-waals | ICL2 | P | 187 | 34x50 | G.H5 | V | 363 | G.H5.15 |
Polar | TM5 | S | 269 | 5x68 | G.h4s6 | R | 338 | G.h4s6.20 |
Van-der-waals | TM5 | S | 269 | 5x68 | G.h4s6 | R | 338 | G.h4s6.20 |
Hydrophobic | C-term | M | 415 | - | G.h2s4 | E | 224 | G.h2s4.02 |
Van-der-waals | C-term | M | 415 | - | G.h2s4 | E | 224 | G.h2s4.02 |
Hydrophobic | C-term | W | 452 | - | G.H1 | R | 63 | G.H1.09 |
Van-der-waals | C-term | W | 452 | - | G.H1 | R | 63 | G.H1.09 |
Polar | TM6 | K | 324 | 6x32 | G.H5 | N | 372 | G.H5.24 |
Hydrophobic | TM6 | K | 324 | 6x32 | G.H5 | N | 372 | G.H5.24 |
Van-der-waals | TM6 | K | 324 | 6x32 | G.H5 | N | 372 | G.H5.24 |
Hydrophobic | TM6 | A | 325 | 6x33 | G.H5 | L | 373 | G.H5.25 |
Hydrophobic | C-term | A | 418 | - | G.H3 | W | 266 | G.H3.17 |
Van-der-waals | C-term | A | 418 | - | G.H3 | W | 266 | G.H3.17 |
Hydrophobic | ICL2 | L | 188 | 34x51 | G.H5 | V | 363 | G.H5.15 |
Hydrophobic | C-term | L | 432 | - | G.H2 | R | 216 | G.H2.04 |
Ionic | TM5 | H | 273 | 5x72 | G.H5 | D | 361 | G.H5.13 |
Polar | TM5 | H | 273 | 5x72 | G.H5 | D | 361 | G.H5.13 |
Hydrophobic | TM5 | H | 273 | 5x72 | G.H5 | D | 361 | G.H5.13 |
Van-der-waals | TM5 | H | 273 | 5x72 | G.H5 | D | 361 | G.H5.13 |
Hydrophobic | TM6 | T | 328 | 6x36 | G.H5 | L | 373 | G.H5.25 |
Van-der-waals | H8 | R | 389 | 8x48 | G.h4s6 | R | 335 | G.h4s6.17 |
Hydrophobic | ICL3 | F | 278 | - | G.H4 | L | 313 | G.H4.12 |
Van-der-waals | ICL3 | F | 278 | - | G.H4 | L | 313 | G.H4.12 |
Hydrophobic | TM5 | A | 266 | 5x65 | G.H5 | L | 368 | G.H5.20 |
Hydrophobic | TM5 | K | 272 | 5x71 | G.H5 | K | 357 | G.H5.09 |
Van-der-waals | TM5 | K | 272 | 5x71 | G.H5 | K | 357 | G.H5.09 |
Hydrophobic | ICL3 | F | 278 | - | G.H4 | R | 310 | G.H4.09 |
Van-der-waals | ICL3 | F | 278 | - | G.H4 | R | 310 | G.H4.09 |
Hydrophobic | TM3 | I | 184 | 3x54 | G.H5 | L | 373 | G.H5.25 |