Golf -
5-HT7 receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 76.6
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.7
iPTM Score: 0.8
PAE mean: 11.9
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Polar | TM6 | T | 328 | 6x36 | G.H5 | E | 379 | G.H5.24 |
Hydrophobic | TM6 | T | 328 | 6x36 | G.H5 | E | 379 | G.H5.24 |
Van-der-waals | TM6 | T | 328 | 6x36 | G.H5 | E | 379 | G.H5.24 |
Hydrophobic | ICL2 | P | 187 | 34x50 | G.H5 | H | 374 | G.H5.19 |
Hydrophobic | C-term | M | 415 | - | G.H3 | W | 268 | G.H3.17 |
Ionic | TM5 | K | 272 | 5x71 | G.H5 | D | 365 | G.H5.10 |
Polar | TM5 | K | 272 | 5x71 | G.H5 | D | 365 | G.H5.10 |
Van-der-waals | TM5 | K | 272 | 5x71 | G.H5 | D | 365 | G.H5.10 |
Polar | TM5 | H | 273 | 5x72 | G.H5 | R | 372 | G.H5.17 |
Aromatic | TM5 | H | 273 | 5x72 | G.H5 | R | 372 | G.H5.17 |
Hydrophobic | TM5 | H | 273 | 5x72 | G.H5 | R | 372 | G.H5.17 |
Van-der-waals | TM5 | H | 273 | 5x72 | G.H5 | R | 372 | G.H5.17 |
Polar | TM6 | R | 321 | 6x29 | G.h4s6 | Y | 345 | G.h4s6.20 |
Hydrophobic | C-term | L | 421 | - | G.H3 | N | 265 | G.H3.14 |
Van-der-waals | C-term | L | 421 | - | G.H3 | N | 265 | G.H3.14 |
Ionic | H8 | R | 392 | 8x51 | G.H5 | E | 379 | G.H5.24 |
Polar | H8 | R | 392 | 8x51 | G.H5 | E | 379 | G.H5.24 |
Hydrophobic | H8 | R | 392 | 8x51 | G.H5 | E | 379 | G.H5.24 |
Van-der-waals | H8 | R | 392 | 8x51 | G.H5 | E | 379 | G.H5.24 |
Hydrophobic | ICL2 | P | 191 | 34x54 | G.H5 | H | 374 | G.H5.19 |
Hydrophobic | C-term | L | 421 | - | G.H3 | R | 267 | G.H3.16 |
Van-der-waals | C-term | L | 421 | - | G.H3 | R | 267 | G.H3.16 |
Hydrophobic | TM3 | I | 184 | 3x54 | G.H5 | Y | 378 | G.H5.23 |
Hydrophobic | C-term | E | 417 | - | G.H3 | R | 267 | G.H3.16 |
Van-der-waals | C-term | E | 417 | - | G.H3 | R | 267 | G.H3.16 |
Hydrophobic | ICL2 | L | 188 | 34x51 | G.H5 | C | 366 | G.H5.11 |
Hydrophobic | ICL2 | L | 188 | 34x51 | G.S3 | V | 204 | G.S3.01 |
Van-der-waals | ICL2 | L | 188 | 34x51 | G.S3 | V | 204 | G.S3.01 |
Hydrophobic | ICL3 | F | 278 | - | G.H4 | R | 334 | G.H4.17 |
Van-der-waals | ICL3 | F | 278 | - | G.H4 | R | 334 | G.H4.17 |
Hydrophobic | ICL2 | L | 188 | 34x51 | G.H5 | I | 370 | G.H5.15 |
Van-der-waals | ICL2 | L | 188 | 34x51 | G.H5 | I | 370 | G.H5.15 |
Polar | TM6 | A | 325 | 6x33 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | TM6 | A | 325 | 6x33 | G.H5 | L | 380 | G.H5.25 |
Van-der-waals | TM6 | A | 325 | 6x33 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | ICL2 | T | 189 | 34x52 | G.S3 | V | 204 | G.S3.01 |
Van-der-waals | ICL2 | T | 189 | 34x52 | G.S3 | V | 204 | G.S3.01 |
Hydrophobic | TM3 | I | 184 | 3x54 | G.H5 | L | 375 | G.H5.20 |
Polar | C-term | L | 419 | - | G.H3 | R | 267 | G.H3.16 |
Hydrophobic | C-term | L | 419 | - | G.H3 | R | 267 | G.H3.16 |
Van-der-waals | C-term | L | 419 | - | G.H3 | R | 267 | G.H3.16 |
Hydrophobic | C-term | L | 421 | - | G.h3s5 | R | 270 | G.h3s5.01 |
Van-der-waals | C-term | L | 421 | - | G.h3s5 | R | 270 | G.h3s5.01 |
Ionic | TM5 | K | 272 | 5x71 | G.H5 | D | 368 | G.H5.13 |
Polar | TM5 | K | 272 | 5x71 | G.H5 | D | 368 | G.H5.13 |
Hydrophobic | TM5 | K | 272 | 5x71 | G.H5 | D | 368 | G.H5.13 |
Van-der-waals | TM5 | K | 272 | 5x71 | G.H5 | D | 368 | G.H5.13 |
Polar | TM5 | S | 269 | 5x68 | G.H5 | R | 372 | G.H5.17 |
Hydrophobic | TM5 | S | 269 | 5x68 | G.H5 | R | 372 | G.H5.17 |
Van-der-waals | TM5 | S | 269 | 5x68 | G.H5 | R | 372 | G.H5.17 |
Ionic | H8 | R | 389 | 8x48 | G.H5 | E | 379 | G.H5.24 |
Polar | H8 | R | 389 | 8x48 | G.H5 | E | 379 | G.H5.24 |
Hydrophobic | H8 | R | 389 | 8x48 | G.H5 | E | 379 | G.H5.24 |
Van-der-waals | H8 | R | 389 | 8x48 | G.H5 | E | 379 | G.H5.24 |
Polar | TM3 | I | 184 | 3x54 | G.H5 | Q | 371 | G.H5.16 |
Hydrophobic | TM3 | I | 184 | 3x54 | G.H5 | Q | 371 | G.H5.16 |
Van-der-waals | TM3 | I | 184 | 3x54 | G.H5 | Q | 371 | G.H5.16 |
Hydrophobic | TM5 | A | 270 | 5x69 | G.H5 | L | 381 | G.H5.26 |
Hydrophobic | TM6 | L | 329 | 6x37 | G.H5 | L | 380 | G.H5.25 |
Van-der-waals | TM6 | L | 329 | 6x37 | G.H5 | L | 380 | G.H5.25 |
Aromatic | TM3 | R | 180 | 3x50 | G.H5 | Y | 378 | G.H5.23 |
Hydrophobic | TM3 | R | 180 | 3x50 | G.H5 | Y | 378 | G.H5.23 |
Hydrophobic | ICL2 | L | 188 | 34x51 | G.H5 | R | 367 | G.H5.12 |
Hydrophobic | C-term | M | 415 | - | G.h2s4 | N | 226 | G.h2s4.02 |
Hydrophobic | ICL2 | L | 188 | 34x51 | G.S1 | H | 43 | G.S1.02 |
Van-der-waals | ICL2 | L | 188 | 34x51 | G.S1 | H | 43 | G.S1.02 |
Hydrophobic | ICL2 | P | 187 | 34x50 | G.H5 | Q | 371 | G.H5.16 |
Hydrophobic | TM5 | A | 266 | 5x65 | G.H5 | L | 375 | G.H5.20 |
Polar | TM5 | H | 273 | 5x72 | G.S6 | Y | 347 | G.S6.02 |
Aromatic | TM5 | H | 273 | 5x72 | G.S6 | Y | 347 | G.S6.02 |
Hydrophobic | TM5 | H | 273 | 5x72 | G.S6 | Y | 347 | G.S6.02 |
Van-der-waals | TM5 | H | 273 | 5x72 | G.S6 | Y | 347 | G.S6.02 |
Hydrophobic | TM5 | I | 262 | 5x61 | G.H5 | L | 380 | G.H5.25 |
Van-der-waals | TM5 | I | 262 | 5x61 | G.H5 | L | 380 | G.H5.25 |
Polar | H8 | R | 389 | 8x48 | G.H5 | K | 376 | G.H5.21 |
Hydrophobic | H8 | R | 389 | 8x48 | G.H5 | K | 376 | G.H5.21 |
Van-der-waals | H8 | R | 389 | 8x48 | G.H5 | K | 376 | G.H5.21 |
Polar | H8 | R | 389 | 8x48 | G.H5 | Q | 377 | G.H5.22 |
Polar | C-term | K | 420 | - | G.H3 | R | 267 | G.H3.16 |
Hydrophobic | C-term | K | 420 | - | G.H3 | R | 267 | G.H3.16 |
Van-der-waals | C-term | K | 420 | - | G.H3 | R | 267 | G.H3.16 |
Polar | TM5 | A | 270 | 5x69 | G.H5 | R | 372 | G.H5.17 |
Van-der-waals | TM5 | A | 270 | 5x69 | G.H5 | R | 372 | G.H5.17 |
Hydrophobic | C-term | A | 422 | - | G.H3 | R | 267 | G.H3.16 |
Van-der-waals | C-term | A | 422 | - | G.H3 | R | 267 | G.H3.16 |
Polar | TM7 | F | 387 | 7x56 | G.H5 | E | 379 | G.H5.24 |
Hydrophobic | TM7 | F | 387 | 7x56 | G.H5 | E | 379 | G.H5.24 |
Hydrophobic | TM3 | I | 184 | 3x54 | G.H5 | H | 374 | G.H5.19 |
Polar | TM5 | S | 269 | 5x68 | G.H5 | D | 368 | G.H5.13 |
Van-der-waals | TM5 | S | 269 | 5x68 | G.H5 | D | 368 | G.H5.13 |
Hydrophobic | TM5 | F | 275 | 5x74 | G.S6 | P | 348 | G.S6.03 |
Van-der-waals | TM5 | F | 275 | 5x74 | G.S6 | P | 348 | G.S6.03 |
Hydrophobic | ICL2 | V | 192 | 34x55 | G.hns1 | A | 41 | G.hns1.03 |
Van-der-waals | ICL2 | V | 192 | 34x55 | G.hns1 | A | 41 | G.hns1.03 |
Polar | TM3 | G | 183 | 3x53 | G.H5 | H | 374 | G.H5.19 |
Hydrophobic | TM3 | G | 183 | 3x53 | G.H5 | H | 374 | G.H5.19 |
Hydrophobic | ICL3 | F | 278 | - | G.H4 | D | 330 | G.H4.13 |
Van-der-waals | ICL3 | F | 278 | - | G.H4 | D | 330 | G.H4.13 |
Hydrophobic | TM6 | K | 324 | 6x32 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | C-term | L | 419 | - | G.H3 | W | 268 | G.H3.17 |
Van-der-waals | C-term | L | 419 | - | G.H3 | W | 268 | G.H3.17 |
Hydrophobic | TM5 | P | 276 | 5x75 | G.hgh4 | D | 310 | G.hgh4.13 |
Van-der-waals | TM5 | P | 276 | 5x75 | G.hgh4 | D | 310 | G.hgh4.13 |
Ionic | C-term | E | 417 | - | G.h4s6 | K | 343 | G.h4s6.12 |
Polar | C-term | E | 417 | - | G.h4s6 | K | 343 | G.h4s6.12 |
Hydrophobic | C-term | E | 417 | - | G.h4s6 | K | 343 | G.h4s6.12 |
Van-der-waals | C-term | E | 417 | - | G.h4s6 | K | 343 | G.h4s6.12 |
Aromatic | TM5 | H | 273 | 5x72 | G.h4s6 | Y | 345 | G.h4s6.20 |
Hydrophobic | TM5 | H | 273 | 5x72 | G.h4s6 | Y | 345 | G.h4s6.20 |
Van-der-waals | TM5 | H | 273 | 5x72 | G.h4s6 | Y | 345 | G.h4s6.20 |
Hydrophobic | ICL2 | P | 187 | 34x50 | G.H5 | R | 367 | G.H5.12 |
Van-der-waals | ICL2 | P | 187 | 34x50 | G.H5 | R | 367 | G.H5.12 |
Hydrophobic | TM5 | S | 269 | 5x68 | G.H5 | L | 375 | G.H5.20 |
Ionic | TM6 | K | 324 | 6x32 | G.H5 | E | 379 | G.H5.24 |
Polar | TM6 | K | 324 | 6x32 | G.H5 | E | 379 | G.H5.24 |
Hydrophobic | TM6 | K | 324 | 6x32 | G.H5 | E | 379 | G.H5.24 |
Van-der-waals | TM6 | K | 324 | 6x32 | G.H5 | E | 379 | G.H5.24 |
Hydrophobic | ICL2 | L | 188 | 34x51 | G.H5 | F | 363 | G.H5.08 |
Van-der-waals | ICL2 | L | 188 | 34x51 | G.H5 | F | 363 | G.H5.08 |
Hydrophobic | TM5 | F | 275 | 5x74 | G.H4 | L | 333 | G.H4.16 |
Van-der-waals | TM5 | F | 275 | 5x74 | G.H4 | L | 333 | G.H4.16 |
Hydrophobic | TM3 | I | 184 | 3x54 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | TM6 | R | 321 | 6x29 | G.H5 | L | 381 | G.H5.26 |
Hydrophobic | ICL3 | F | 278 | - | G.H4 | L | 333 | G.H4.16 |
Van-der-waals | ICL3 | F | 278 | - | G.H4 | L | 333 | G.H4.16 |
Polar | H8 | R | 389 | 8x48 | G.H5 | L | 381 | G.H5.26 |
Hydrophobic | TM5 | S | 269 | 5x68 | G.H5 | Q | 371 | G.H5.16 |
Polar | ICL3 | R | 280 | - | G.h4s6 | G | 340 | G.h4s6.09 |
Hydrophobic | ICL3 | R | 280 | - | G.h4s6 | G | 340 | G.h4s6.09 |
Van-der-waals | ICL3 | R | 280 | - | G.h4s6 | G | 340 | G.h4s6.09 |
Polar | C-term | A | 418 | - | G.H3 | W | 268 | G.H3.17 |
Hydrophobic | C-term | A | 418 | - | G.H3 | W | 268 | G.H3.17 |
Van-der-waals | C-term | A | 418 | - | G.H3 | W | 268 | G.H3.17 |
Polar | TM6 | K | 324 | 6x32 | G.H5 | L | 381 | G.H5.26 |
Hydrophobic | TM6 | K | 324 | 6x32 | G.H5 | L | 381 | G.H5.26 |
Van-der-waals | TM6 | K | 324 | 6x32 | G.H5 | L | 381 | G.H5.26 |
Hydrophobic | TM6 | T | 328 | 6x36 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | TM7 | F | 387 | 7x56 | G.H5 | Y | 378 | G.H5.23 |
Van-der-waals | TM7 | F | 387 | 7x56 | G.H5 | Y | 378 | G.H5.23 |
Ionic | TM5 | H | 273 | 5x72 | G.H5 | D | 368 | G.H5.13 |
Polar | TM5 | H | 273 | 5x72 | G.H5 | D | 368 | G.H5.13 |
Van-der-waals | TM5 | H | 273 | 5x72 | G.H5 | D | 368 | G.H5.13 |
Hydrophobic | ICL2 | P | 187 | 34x50 | G.H5 | I | 370 | G.H5.15 |
Van-der-waals | ICL2 | P | 187 | 34x50 | G.H5 | I | 370 | G.H5.15 |
Polar | C-term | A | 418 | - | G.H3 | R | 267 | G.H3.16 |
Hydrophobic | C-term | A | 418 | - | G.H3 | R | 267 | G.H3.16 |
Van-der-waals | C-term | A | 418 | - | G.H3 | R | 267 | G.H3.16 |
Hydrophobic | TM5 | K | 272 | 5x71 | G.S6 | Y | 347 | G.S6.02 |
Van-der-waals | TM5 | K | 272 | 5x71 | G.S6 | Y | 347 | G.S6.02 |
Hydrophobic | ICL3 | F | 278 | - | G.h4s6 | T | 337 | G.h4s6.03 |