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5-HT7 receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 75.2
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 13.6
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | ICL2 | L | 188 | 34x51 | G.H5 | T | 340 | G.H5.12 |
Van-der-waals | ICL2 | L | 188 | 34x51 | G.H5 | T | 340 | G.H5.12 |
Hydrophobic | TM3 | I | 184 | 3x54 | G.H5 | L | 348 | G.H5.20 |
Van-der-waals | TM3 | I | 184 | 3x54 | G.H5 | L | 348 | G.H5.20 |
Hydrophobic | ICL2 | L | 188 | 34x51 | G.H5 | F | 336 | G.H5.08 |
Van-der-waals | ICL2 | L | 188 | 34x51 | G.H5 | F | 336 | G.H5.08 |
Polar | TM5 | H | 273 | 5x72 | G.S6 | Y | 320 | G.S6.02 |
Aromatic | TM5 | H | 273 | 5x72 | G.S6 | Y | 320 | G.S6.02 |
Hydrophobic | TM5 | H | 273 | 5x72 | G.S6 | Y | 320 | G.S6.02 |
Van-der-waals | TM5 | H | 273 | 5x72 | G.S6 | Y | 320 | G.S6.02 |
Polar | C-term | F | 430 | - | G.hfs2 | K | 181 | G.hfs2.04 |
Hydrophobic | C-term | F | 430 | - | G.hfs2 | K | 181 | G.hfs2.04 |
Van-der-waals | C-term | F | 430 | - | G.hfs2 | K | 181 | G.hfs2.04 |
Hydrophobic | TM5 | S | 269 | 5x68 | G.H5 | I | 344 | G.H5.16 |
Hydrophobic | C-term | E | 417 | - | G.H3 | F | 259 | G.H3.17 |
Van-der-waals | C-term | E | 417 | - | G.H3 | F | 259 | G.H3.17 |
Hydrophobic | H8 | R | 389 | 8x48 | G.H5 | R | 349 | G.H5.21 |
Hydrophobic | TM5 | F | 275 | 5x74 | G.S6 | Y | 320 | G.S6.02 |
Ionic | TM5 | H | 273 | 5x72 | G.H5 | D | 341 | G.H5.13 |
Polar | TM5 | H | 273 | 5x72 | G.H5 | D | 341 | G.H5.13 |
Hydrophobic | TM5 | H | 273 | 5x72 | G.H5 | D | 341 | G.H5.13 |
Van-der-waals | TM5 | H | 273 | 5x72 | G.H5 | D | 341 | G.H5.13 |
Hydrophobic | C-term | A | 418 | - | G.H3 | F | 259 | G.H3.17 |
Van-der-waals | C-term | A | 418 | - | G.H3 | F | 259 | G.H3.17 |
Hydrophobic | C-term | A | 434 | - | G.S2 | V | 186 | G.S2.02 |
Hydrophobic | ICL2 | P | 187 | 34x50 | G.H5 | I | 344 | G.H5.16 |
Van-der-waals | ICL2 | P | 187 | 34x50 | G.H5 | I | 344 | G.H5.16 |
Polar | ICL3 | K | 310 | - | G.H4 | A | 306 | G.H4.13 |
Van-der-waals | ICL3 | K | 310 | - | G.H4 | A | 306 | G.H4.13 |
Polar | C-term | E | 426 | - | G.H2 | S | 207 | G.H2.02 |
Hydrophobic | C-term | E | 426 | - | G.H2 | S | 207 | G.H2.02 |
Van-der-waals | C-term | E | 426 | - | G.H2 | S | 207 | G.H2.02 |
Hydrophobic | C-term | H | 416 | - | G.H3 | K | 258 | G.H3.16 |
Polar | C-term | E | 429 | - | G.s3h2 | Q | 205 | G.s3h2.03 |
Van-der-waals | C-term | E | 429 | - | G.s3h2 | Q | 205 | G.s3h2.03 |
Hydrophobic | C-term | L | 454 | - | H.HA | Q | 68 | H.HA.06 |
Van-der-waals | C-term | L | 454 | - | H.HA | Q | 68 | H.HA.06 |
Polar | C-term | A | 434 | - | G.hfs2 | T | 183 | G.hfs2.06 |
Polar | TM6 | A | 325 | 6x33 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | TM6 | A | 325 | 6x33 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM6 | A | 325 | 6x33 | G.H5 | L | 353 | G.H5.25 |
Polar | TM5 | A | 270 | 5x69 | G.H5 | Y | 354 | G.H5.26 |
Hydrophobic | TM5 | A | 270 | 5x69 | G.H5 | Y | 354 | G.H5.26 |
Ionic | TM6 | R | 321 | 6x29 | G.h4s6 | E | 318 | G.h4s6.12 |
Polar | TM6 | R | 321 | 6x29 | G.h4s6 | E | 318 | G.h4s6.12 |
Hydrophobic | TM6 | R | 321 | 6x29 | G.h4s6 | E | 318 | G.h4s6.12 |
Van-der-waals | TM6 | R | 321 | 6x29 | G.h4s6 | E | 318 | G.h4s6.12 |
Hydrophobic | C-term | M | 415 | - | G.H3 | F | 259 | G.H3.17 |
Van-der-waals | C-term | M | 415 | - | G.H3 | F | 259 | G.H3.17 |
Hydrophobic | TM6 | T | 328 | 6x36 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM6 | T | 328 | 6x36 | G.H5 | L | 353 | G.H5.25 |
Ionic | ICL1 | K | 110 | 12x48 | G.HN | E | 20 | G.HN.44 |
Polar | ICL1 | K | 110 | 12x48 | G.HN | E | 20 | G.HN.44 |
Hydrophobic | TM5 | I | 262 | 5x61 | G.H5 | L | 348 | G.H5.20 |
Polar | C-term | E | 423 | - | G.H2 | K | 210 | G.H2.05 |
Hydrophobic | C-term | E | 423 | - | G.H2 | K | 210 | G.H2.05 |
Van-der-waals | C-term | E | 423 | - | G.H2 | K | 210 | G.H2.05 |
Hydrophobic | C-term | A | 418 | - | G.H2 | H | 214 | G.H2.09 |
Van-der-waals | C-term | A | 418 | - | G.H2 | H | 214 | G.H2.09 |
Hydrophobic | ICL2 | P | 187 | 34x50 | G.H5 | T | 340 | G.H5.12 |
Polar | C-term | R | 424 | - | G.H2 | K | 210 | G.H2.05 |
Hydrophobic | C-term | R | 424 | - | G.H2 | K | 210 | G.H2.05 |
Van-der-waals | C-term | R | 424 | - | G.H2 | K | 210 | G.H2.05 |
Polar | TM5 | S | 269 | 5x68 | G.H5 | Y | 354 | G.H5.26 |
Hydrophobic | C-term | H | 416 | - | G.H3 | F | 259 | G.H3.17 |
Van-der-waals | C-term | H | 416 | - | G.H3 | F | 259 | G.H3.17 |
Polar | C-term | G | 414 | - | G.h2s4 | E | 217 | G.h2s4.02 |
Hydrophobic | C-term | G | 414 | - | G.h2s4 | E | 217 | G.h2s4.02 |
Van-der-waals | C-term | G | 414 | - | G.h2s4 | E | 217 | G.h2s4.02 |
Polar | TM7 | F | 387 | 7x56 | G.H5 | G | 352 | G.H5.24 |
Hydrophobic | TM7 | F | 387 | 7x56 | G.H5 | G | 352 | G.H5.24 |
Van-der-waals | TM7 | F | 387 | 7x56 | G.H5 | G | 352 | G.H5.24 |
Hydrophobic | ICL3 | F | 278 | - | G.H4 | E | 298 | G.H4.04 |
Hydrophobic | C-term | V | 431 | - | G.H2 | E | 208 | G.H2.03 |
Polar | C-term | W | 452 | - | H.HA | Q | 68 | H.HA.06 |
Van-der-waals | C-term | W | 452 | - | H.HA | Q | 68 | H.HA.06 |
Hydrophobic | TM5 | I | 262 | 5x61 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM5 | I | 262 | 5x61 | G.H5 | L | 353 | G.H5.25 |
Polar | TM6 | T | 328 | 6x36 | G.H5 | G | 352 | G.H5.24 |
Hydrophobic | TM6 | T | 328 | 6x36 | G.H5 | G | 352 | G.H5.24 |
Van-der-waals | TM6 | T | 328 | 6x36 | G.H5 | G | 352 | G.H5.24 |
Hydrophobic | C-term | E | 426 | - | G.H2 | R | 206 | G.H2.01 |
Van-der-waals | C-term | E | 426 | - | G.H2 | R | 206 | G.H2.01 |
Hydrophobic | C-term | W | 452 | - | G.S2 | V | 186 | G.S2.02 |
Van-der-waals | C-term | W | 452 | - | G.S2 | V | 186 | G.S2.02 |
Polar | TM6 | K | 324 | 6x32 | G.H5 | Y | 354 | G.H5.26 |
Hydrophobic | TM6 | K | 324 | 6x32 | G.H5 | Y | 354 | G.H5.26 |
Van-der-waals | TM6 | K | 324 | 6x32 | G.H5 | Y | 354 | G.H5.26 |
Polar | TM3 | G | 183 | 3x53 | G.H5 | N | 347 | G.H5.19 |
Van-der-waals | TM3 | G | 183 | 3x53 | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | ICL2 | P | 187 | 34x50 | G.H5 | I | 343 | G.H5.15 |
Van-der-waals | ICL2 | P | 187 | 34x50 | G.H5 | I | 343 | G.H5.15 |
Hydrophobic | C-term | G | 414 | - | G.H3 | F | 259 | G.H3.17 |
Van-der-waals | C-term | G | 414 | - | G.H3 | F | 259 | G.H3.17 |
Hydrophobic | ICL2 | L | 188 | 34x51 | G.S3 | L | 195 | G.S3.01 |
Van-der-waals | ICL2 | L | 188 | 34x51 | G.S3 | L | 195 | G.S3.01 |
Hydrophobic | C-term | L | 432 | - | G.hfs2 | K | 181 | G.hfs2.04 |
Van-der-waals | C-term | L | 432 | - | G.hfs2 | K | 181 | G.hfs2.04 |
Polar | TM6 | R | 321 | 6x29 | G.H5 | Y | 354 | G.H5.26 |
Hydrophobic | TM6 | R | 321 | 6x29 | G.H5 | Y | 354 | G.H5.26 |
Van-der-waals | TM6 | R | 321 | 6x29 | G.H5 | Y | 354 | G.H5.26 |
Ionic | H8 | R | 389 | 8x48 | G.h3s5 | D | 262 | G.h3s5.02 |
Polar | H8 | R | 389 | 8x48 | G.h3s5 | D | 262 | G.h3s5.02 |
Hydrophobic | H8 | R | 389 | 8x48 | G.h3s5 | D | 262 | G.h3s5.02 |
Van-der-waals | H8 | R | 389 | 8x48 | G.h3s5 | D | 262 | G.h3s5.02 |
Polar | TM6 | R | 321 | 6x29 | G.h4s6 | P | 315 | G.h4s6.09 |
Polar | ICL3 | K | 310 | - | G.H4 | S | 310 | G.H4.17 |
Hydrophobic | ICL3 | K | 310 | - | G.H4 | S | 310 | G.H4.17 |
Van-der-waals | ICL3 | K | 310 | - | G.H4 | S | 310 | G.H4.17 |
Ionic | C-term | E | 429 | - | G.hfs2 | K | 181 | G.hfs2.04 |
Polar | C-term | E | 429 | - | G.hfs2 | K | 181 | G.hfs2.04 |
Van-der-waals | C-term | E | 429 | - | G.hfs2 | K | 181 | G.hfs2.04 |
Hydrophobic | C-term | A | 413 | - | G.H3 | F | 259 | G.H3.17 |
Van-der-waals | C-term | A | 413 | - | G.H3 | F | 259 | G.H3.17 |
Polar | C-term | A | 422 | - | G.H2 | K | 210 | G.H2.05 |
Hydrophobic | C-term | A | 422 | - | G.H2 | K | 210 | G.H2.05 |
Van-der-waals | C-term | A | 422 | - | G.H2 | K | 210 | G.H2.05 |
Hydrophobic | TM3 | I | 184 | 3x54 | G.H5 | I | 344 | G.H5.16 |
Hydrophobic | ICL2 | L | 188 | 34x51 | G.H5 | I | 343 | G.H5.15 |
Van-der-waals | ICL2 | L | 188 | 34x51 | G.H5 | I | 343 | G.H5.15 |
Hydrophobic | TM5 | F | 275 | 5x74 | G.S6 | I | 319 | G.S6.01 |
Van-der-waals | TM5 | F | 275 | 5x74 | G.S6 | I | 319 | G.S6.01 |
Hydrophobic | C-term | M | 415 | - | G.H2 | H | 214 | G.H2.09 |
Van-der-waals | C-term | M | 415 | - | G.H2 | H | 214 | G.H2.09 |
Ionic | C-term | E | 417 | - | G.H3 | K | 258 | G.H3.16 |
Polar | C-term | E | 417 | - | G.H3 | K | 258 | G.H3.16 |
Hydrophobic | C-term | E | 417 | - | G.H3 | K | 258 | G.H3.16 |
Van-der-waals | C-term | E | 417 | - | G.H3 | K | 258 | G.H3.16 |
Hydrophobic | TM3 | I | 184 | 3x54 | G.H5 | N | 347 | G.H5.19 |
Ionic | TM5 | H | 273 | 5x72 | G.h4s6 | E | 318 | G.h4s6.12 |
Polar | TM5 | H | 273 | 5x72 | G.h4s6 | E | 318 | G.h4s6.12 |
Hydrophobic | TM5 | H | 273 | 5x72 | G.h4s6 | E | 318 | G.h4s6.12 |
Van-der-waals | TM5 | H | 273 | 5x72 | G.h4s6 | E | 318 | G.h4s6.12 |
Ionic | ICL3 | R | 280 | - | G.H4 | D | 299 | G.H4.05 |
Polar | ICL3 | R | 280 | - | G.H4 | D | 299 | G.H4.05 |
Van-der-waals | ICL3 | R | 280 | - | G.H4 | D | 299 | G.H4.05 |
Hydrophobic | TM5 | A | 266 | 5x65 | G.H5 | L | 348 | G.H5.20 |
Hydrophobic | C-term | V | 431 | - | G.hfs2 | T | 183 | G.hfs2.06 |
Van-der-waals | C-term | V | 431 | - | G.hfs2 | T | 183 | G.hfs2.06 |
Hydrophobic | C-term | A | 418 | - | G.H2 | I | 213 | G.H2.08 |
Van-der-waals | C-term | A | 418 | - | G.H2 | I | 213 | G.H2.08 |
Polar | TM5 | S | 269 | 5x68 | G.H5 | D | 341 | G.H5.13 |
Hydrophobic | TM5 | S | 269 | 5x68 | G.H5 | D | 341 | G.H5.13 |
Van-der-waals | TM5 | S | 269 | 5x68 | G.H5 | D | 341 | G.H5.13 |
Hydrophobic | ICL3 | R | 280 | - | G.H4 | Y | 303 | G.H4.10 |
Van-der-waals | ICL3 | R | 280 | - | G.H4 | Y | 303 | G.H4.10 |
Polar | C-term | L | 432 | - | G.hfs2 | T | 183 | G.hfs2.06 |
Hydrophobic | C-term | L | 432 | - | G.hfs2 | T | 183 | G.hfs2.06 |
Van-der-waals | C-term | L | 432 | - | G.hfs2 | T | 183 | G.hfs2.06 |
Hydrophobic | ICL3 | F | 278 | - | G.H4 | A | 302 | G.H4.08 |
Van-der-waals | ICL3 | F | 278 | - | G.H4 | A | 302 | G.H4.08 |
Polar | ICL2 | V | 192 | 34x55 | G.hns1 | K | 32 | G.hns1.03 |
Hydrophobic | ICL2 | V | 192 | 34x55 | G.hns1 | K | 32 | G.hns1.03 |
Van-der-waals | ICL2 | V | 192 | 34x55 | G.hns1 | K | 32 | G.hns1.03 |
Ionic | C-term | E | 426 | - | G.H2 | K | 210 | G.H2.05 |
Polar | C-term | E | 426 | - | G.H2 | K | 210 | G.H2.05 |
Hydrophobic | C-term | E | 426 | - | G.H2 | K | 210 | G.H2.05 |
Van-der-waals | C-term | E | 426 | - | G.H2 | K | 210 | G.H2.05 |
Hydrophobic | TM5 | F | 275 | 5x74 | G.S6 | C | 321 | G.S6.03 |
Hydrophobic | C-term | L | 432 | - | G.hfs2 | V | 180 | G.hfs2.03 |
Polar | TM3 | R | 180 | 3x50 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | TM3 | R | 180 | 3x50 | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | TM3 | R | 180 | 3x50 | G.H5 | C | 351 | G.H5.23 |
Ionic | ICL3 | K | 314 | - | G.H4 | E | 309 | G.H4.16 |
Polar | ICL3 | K | 314 | - | G.H4 | E | 309 | G.H4.16 |
Hydrophobic | ICL3 | K | 314 | - | G.H4 | E | 309 | G.H4.16 |
Van-der-waals | ICL3 | K | 314 | - | G.H4 | E | 309 | G.H4.16 |
Polar | ICL3 | R | 280 | - | G.hgh4 | Y | 291 | G.hgh4.05 |
Hydrophobic | ICL3 | R | 280 | - | G.hgh4 | Y | 291 | G.hgh4.05 |
Van-der-waals | ICL3 | R | 280 | - | G.hgh4 | Y | 291 | G.hgh4.05 |
Hydrophobic | TM6 | L | 329 | 6x37 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM6 | L | 329 | 6x37 | G.H5 | L | 353 | G.H5.25 |
Ionic | TM5 | K | 272 | 5x71 | G.H5 | D | 341 | G.H5.13 |
Polar | TM5 | K | 272 | 5x71 | G.H5 | D | 341 | G.H5.13 |
Hydrophobic | TM5 | K | 272 | 5x71 | G.H5 | D | 341 | G.H5.13 |
Van-der-waals | TM5 | K | 272 | 5x71 | G.H5 | D | 341 | G.H5.13 |
Van-der-waals | H8 | R | 389 | 8x48 | G.h4s6 | N | 316 | G.h4s6.10 |