Gt1 -
5-HT7 receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 75.7
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 14.2
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | C-term | V | 471 | - | G.S2 | E | 182 | G.S2.03 |
Hydrophobic | C-term | A | 422 | - | G.h4s6 | R | 309 | G.h4s6.04 |
Van-der-waals | C-term | A | 422 | - | G.h4s6 | R | 309 | G.h4s6.04 |
Polar | TM5 | S | 269 | 5x68 | G.H5 | D | 337 | G.H5.13 |
Hydrophobic | TM5 | S | 269 | 5x68 | G.H5 | D | 337 | G.H5.13 |
Van-der-waals | TM5 | S | 269 | 5x68 | G.H5 | D | 337 | G.H5.13 |
Hydrophobic | ICL2 | L | 188 | 34x51 | G.H5 | T | 336 | G.H5.12 |
Hydrophobic | C-term | L | 454 | - | G.H3 | R | 253 | G.H3.16 |
Van-der-waals | C-term | L | 454 | - | G.H3 | R | 253 | G.H3.16 |
Hydrophobic | C-term | L | 421 | - | G.h4s6 | V | 312 | G.h4s6.10 |
Ionic | TM5 | K | 272 | 5x71 | G.H5 | D | 337 | G.H5.13 |
Polar | C-term | E | 472 | - | G.S2 | I | 180 | G.S2.01 |
Polar | TM5 | H | 273 | 5x72 | G.S6 | Y | 316 | G.S6.02 |
Hydrophobic | TM5 | H | 273 | 5x72 | G.S6 | Y | 316 | G.S6.02 |
Van-der-waals | TM5 | H | 273 | 5x72 | G.S6 | Y | 316 | G.S6.02 |
Aromatic | TM5 | H | 273 | 5x72 | G.H5 | K | 341 | G.H5.17 |
Hydrophobic | TM5 | H | 273 | 5x72 | G.H5 | K | 341 | G.H5.17 |
Van-der-waals | TM5 | H | 273 | 5x72 | G.H5 | K | 341 | G.H5.17 |
Hydrophobic | TM6 | K | 324 | 6x32 | G.H5 | L | 349 | G.H5.25 |
Polar | TM6 | T | 328 | 6x36 | G.H5 | G | 348 | G.H5.24 |
Hydrophobic | TM6 | T | 328 | 6x36 | G.H5 | G | 348 | G.H5.24 |
Van-der-waals | TM6 | T | 328 | 6x36 | G.H5 | G | 348 | G.H5.24 |
Hydrophobic | C-term | A | 418 | - | G.h3s5 | T | 257 | G.h3s5.02 |
Van-der-waals | C-term | A | 418 | - | G.h3s5 | T | 257 | G.h3s5.02 |
Hydrophobic | C-term | R | 446 | - | G.s4h3 | V | 236 | G.s4h3.14 |
Van-der-waals | C-term | R | 446 | - | G.s4h3 | V | 236 | G.s4h3.14 |
Polar | TM6 | R | 321 | 6x29 | G.h4s6 | D | 311 | G.h4s6.09 |
Van-der-waals | TM6 | R | 321 | 6x29 | G.h4s6 | D | 311 | G.h4s6.09 |
Hydrophobic | TM4 | N | 195 | 4x38 | G.HN | E | 24 | G.HN.52 |
Van-der-waals | TM4 | N | 195 | 4x38 | G.HN | E | 24 | G.HN.52 |
Hydrophobic | TM5 | S | 269 | 5x68 | G.H5 | I | 340 | G.H5.16 |
Hydrophobic | ICL2 | P | 187 | 34x50 | G.H5 | I | 340 | G.H5.16 |
Van-der-waals | ICL2 | P | 187 | 34x50 | G.H5 | I | 340 | G.H5.16 |
Hydrophobic | ICL2 | L | 188 | 34x51 | G.S3 | L | 190 | G.S3.01 |
Polar | TM3 | G | 183 | 3x53 | G.H5 | N | 343 | G.H5.19 |
Hydrophobic | TM3 | G | 183 | 3x53 | G.H5 | N | 343 | G.H5.19 |
Van-der-waals | TM3 | G | 183 | 3x53 | G.H5 | N | 343 | G.H5.19 |
Polar | C-term | W | 452 | - | G.H2 | K | 205 | G.H2.05 |
Hydrophobic | C-term | W | 452 | - | G.H2 | K | 205 | G.H2.05 |
Van-der-waals | C-term | W | 452 | - | G.H2 | K | 205 | G.H2.05 |
Hydrophobic | C-term | A | 418 | - | G.h3s5 | A | 256 | G.h3s5.01 |
Ionic | C-term | H | 478 | - | G.h1ha | D | 55 | G.h1ha.02 |
Polar | C-term | H | 478 | - | G.h1ha | D | 55 | G.h1ha.02 |
Hydrophobic | C-term | H | 478 | - | G.h1ha | D | 55 | G.h1ha.02 |
Van-der-waals | C-term | H | 478 | - | G.h1ha | D | 55 | G.h1ha.02 |
Hydrophobic | TM5 | F | 275 | 5x74 | G.H4 | L | 304 | G.H4.16 |
Van-der-waals | TM5 | F | 275 | 5x74 | G.H4 | L | 304 | G.H4.16 |
Ionic | ICL1 | K | 110 | 12x48 | G.HN | E | 16 | G.HN.44 |
Polar | ICL1 | K | 110 | 12x48 | G.HN | E | 16 | G.HN.44 |
Van-der-waals | ICL1 | K | 110 | 12x48 | G.HN | E | 16 | G.HN.44 |
Hydrophobic | TM5 | A | 266 | 5x65 | G.H5 | L | 344 | G.H5.20 |
Polar | C-term | K | 474 | - | G.S2 | E | 182 | G.S2.03 |
Ionic | C-term | R | 446 | - | G.s4h3 | D | 233 | G.s4h3.11 |
Hydrophobic | TM5 | F | 275 | 5x74 | G.S6 | I | 315 | G.S6.01 |
Van-der-waals | TM5 | F | 275 | 5x74 | G.S6 | I | 315 | G.S6.01 |
Hydrophobic | ICL2 | L | 188 | 34x51 | G.H5 | F | 332 | G.H5.08 |
Van-der-waals | ICL2 | L | 188 | 34x51 | G.H5 | F | 332 | G.H5.08 |
Polar | ICL2 | V | 192 | 34x55 | G.hns1 | R | 28 | G.hns1.03 |
Hydrophobic | ICL2 | V | 192 | 34x55 | G.hns1 | R | 28 | G.hns1.03 |
Van-der-waals | ICL2 | V | 192 | 34x55 | G.hns1 | R | 28 | G.hns1.03 |
Hydrophobic | TM5 | I | 262 | 5x61 | G.H5 | L | 349 | G.H5.25 |
Van-der-waals | TM5 | I | 262 | 5x61 | G.H5 | L | 349 | G.H5.25 |
Ionic | TM6 | R | 321 | 6x29 | G.h4s6 | E | 314 | G.h4s6.12 |
Polar | TM6 | R | 321 | 6x29 | G.h4s6 | E | 314 | G.h4s6.12 |
Hydrophobic | TM6 | R | 321 | 6x29 | G.h4s6 | E | 314 | G.h4s6.12 |
Van-der-waals | TM6 | R | 321 | 6x29 | G.h4s6 | E | 314 | G.h4s6.12 |
Hydrophobic | C-term | L | 454 | - | G.H3 | Y | 254 | G.H3.17 |
Hydrophobic | TM6 | L | 329 | 6x37 | G.H5 | L | 349 | G.H5.25 |
Polar | TM3 | R | 180 | 3x50 | G.H5 | C | 347 | G.H5.23 |
Hydrophobic | TM3 | R | 180 | 3x50 | G.H5 | C | 347 | G.H5.23 |
Van-der-waals | TM3 | R | 180 | 3x50 | G.H5 | C | 347 | G.H5.23 |
Polar | C-term | A | 418 | - | G.h4s6 | R | 309 | G.h4s6.04 |
Van-der-waals | C-term | A | 418 | - | G.h4s6 | R | 309 | G.h4s6.04 |
Hydrophobic | ICL2 | P | 187 | 34x50 | G.H5 | I | 339 | G.H5.15 |
Van-der-waals | ICL2 | P | 187 | 34x50 | G.H5 | I | 339 | G.H5.15 |
Ionic | C-term | R | 446 | - | G.s4h3 | E | 235 | G.s4h3.13 |
Polar | C-term | R | 446 | - | G.s4h3 | E | 235 | G.s4h3.13 |
Hydrophobic | C-term | R | 446 | - | G.s4h3 | E | 235 | G.s4h3.13 |
Van-der-waals | C-term | R | 446 | - | G.s4h3 | E | 235 | G.s4h3.13 |
Polar | TM7 | F | 387 | 7x56 | G.H5 | G | 348 | G.H5.24 |
Hydrophobic | TM7 | F | 387 | 7x56 | G.H5 | G | 348 | G.H5.24 |
Van-der-waals | TM7 | F | 387 | 7x56 | G.H5 | G | 348 | G.H5.24 |
Hydrophobic | TM3 | I | 184 | 3x54 | G.H5 | L | 344 | G.H5.20 |
Van-der-waals | TM3 | I | 184 | 3x54 | G.H5 | L | 344 | G.H5.20 |
Polar | TM6 | K | 324 | 6x32 | G.H5 | F | 350 | G.H5.26 |
Hydrophobic | TM6 | K | 324 | 6x32 | G.H5 | F | 350 | G.H5.26 |
Van-der-waals | TM6 | K | 324 | 6x32 | G.H5 | F | 350 | G.H5.26 |
Hydrophobic | TM3 | I | 184 | 3x54 | G.H5 | L | 349 | G.H5.25 |
Polar | TM6 | A | 325 | 6x33 | G.H5 | L | 349 | G.H5.25 |
Hydrophobic | TM6 | A | 325 | 6x33 | G.H5 | L | 349 | G.H5.25 |
Van-der-waals | TM6 | A | 325 | 6x33 | G.H5 | L | 349 | G.H5.25 |
Hydrophobic | C-term | W | 452 | - | G.H2 | I | 208 | G.H2.08 |
Van-der-waals | C-term | W | 452 | - | G.H2 | I | 208 | G.H2.08 |
Hydrophobic | ICL2 | L | 188 | 34x51 | G.H5 | I | 339 | G.H5.15 |
Van-der-waals | ICL2 | L | 188 | 34x51 | G.H5 | I | 339 | G.H5.15 |
Hydrophobic | ICL2 | P | 187 | 34x50 | G.H5 | T | 336 | G.H5.12 |
Hydrophobic | TM6 | R | 321 | 6x29 | G.H5 | F | 350 | G.H5.26 |
Van-der-waals | TM6 | R | 321 | 6x29 | G.H5 | F | 350 | G.H5.26 |
Hydrophobic | TM6 | T | 328 | 6x36 | G.H5 | L | 349 | G.H5.25 |
Van-der-waals | TM6 | T | 328 | 6x36 | G.H5 | L | 349 | G.H5.25 |
Van-der-waals | C-term | V | 451 | - | G.H3 | S | 248 | G.H3.11 |
Hydrophobic | C-term | M | 476 | - | G.H1 | K | 50 | G.H1.09 |
Van-der-waals | C-term | M | 476 | - | G.H1 | K | 50 | G.H1.09 |
Hydrophobic | TM3 | I | 184 | 3x54 | G.H5 | C | 347 | G.H5.23 |
Ionic | TM5 | H | 273 | 5x72 | G.H5 | D | 337 | G.H5.13 |
Polar | TM5 | H | 273 | 5x72 | G.H5 | D | 337 | G.H5.13 |
Hydrophobic | TM5 | H | 273 | 5x72 | G.H5 | D | 337 | G.H5.13 |
Van-der-waals | TM5 | H | 273 | 5x72 | G.H5 | D | 337 | G.H5.13 |
Hydrophobic | ICL3 | F | 278 | - | G.H4 | N | 297 | G.H4.08 |
Van-der-waals | ICL3 | F | 278 | - | G.H4 | N | 297 | G.H4.08 |
Ionic | ICL3 | R | 280 | - | G.hgh4 | D | 287 | G.hgh4.06 |
Polar | ICL3 | R | 280 | - | G.hgh4 | D | 287 | G.hgh4.06 |
Hydrophobic | C-term | M | 476 | - | G.h1ha | Q | 54 | G.h1ha.01 |
Van-der-waals | C-term | M | 476 | - | G.h1ha | Q | 54 | G.h1ha.01 |
Hydrophobic | C-term | M | 415 | - | G.H3 | Y | 254 | G.H3.17 |
Ionic | ICL3 | K | 310 | - | G.H4 | E | 305 | G.H4.17 |
Polar | ICL3 | K | 310 | - | G.H4 | E | 305 | G.H4.17 |
Hydrophobic | ICL3 | K | 310 | - | G.H4 | E | 305 | G.H4.17 |
Van-der-waals | ICL3 | K | 310 | - | G.H4 | E | 305 | G.H4.17 |
Hydrophobic | ICL2 | T | 189 | 34x52 | G.s2s3 | D | 189 | G.s2s3.02 |
Van-der-waals | ICL2 | T | 189 | 34x52 | G.s2s3 | D | 189 | G.s2s3.02 |
Hydrophobic | TM6 | K | 324 | 6x32 | G.H5 | G | 348 | G.H5.24 |
Van-der-waals | TM6 | K | 324 | 6x32 | G.H5 | G | 348 | G.H5.24 |
Hydrophobic | C-term | V | 439 | - | G.hgh4 | P | 284 | G.hgh4.03 |
Polar | C-term | E | 472 | - | G.S2 | E | 182 | G.S2.03 |
Ionic | C-term | K | 474 | - | H.HA | E | 61 | H.HA.03 |
Polar | C-term | K | 474 | - | H.HA | E | 61 | H.HA.03 |
Ionic | TM5 | H | 273 | 5x72 | G.h4s6 | E | 314 | G.h4s6.12 |
Polar | TM5 | H | 273 | 5x72 | G.h4s6 | E | 314 | G.h4s6.12 |
Hydrophobic | TM5 | H | 273 | 5x72 | G.h4s6 | E | 314 | G.h4s6.12 |
Van-der-waals | TM5 | H | 273 | 5x72 | G.h4s6 | E | 314 | G.h4s6.12 |
Hydrophobic | TM3 | I | 184 | 3x54 | G.H5 | N | 343 | G.H5.19 |
Polar | C-term | W | 452 | - | G.H2 | R | 204 | G.H2.04 |
Van-der-waals | C-term | W | 452 | - | G.H2 | R | 204 | G.H2.04 |