G11 -
A2A receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 83.5
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 11.6
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
Gβ,
Gγ,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | C-term | L | 363 | - | H.HA | K | 77 | H.HA.09 |
Van-der-waals | C-term | L | 363 | - | H.HA | K | 77 | H.HA.09 |
Polar | C-term | Y | 361 | - | H.hbhc | E | 119 | H.hbhc.01 |
Hydrophobic | C-term | Y | 361 | - | H.hbhc | E | 119 | H.hbhc.01 |
Van-der-waals | C-term | Y | 361 | - | H.hbhc | E | 119 | H.hbhc.01 |
Van-der-waals | C-term | R | 337 | - | G.H3 | Y | 261 | G.H3.15 |
Polar | TM6 | S | 234 | 6x36 | G.H5 | N | 357 | G.H5.24 |
Polar | TM5 | Q | 207 | 5x68 | G.H5 | D | 346 | G.H5.13 |
Hydrophobic | TM5 | Q | 207 | 5x68 | G.H5 | D | 346 | G.H5.13 |
Van-der-waals | TM5 | Q | 207 | 5x68 | G.H5 | D | 346 | G.H5.13 |
Hydrophobic | TM5 | A | 204 | 5x65 | G.H5 | L | 353 | G.H5.20 |
Hydrophobic | TM5 | M | 211 | 5x72 | G.H5 | Q | 350 | G.H5.17 |
Van-der-waals | TM5 | M | 211 | 5x72 | G.H5 | Q | 350 | G.H5.17 |
Polar | C-term | L | 338 | - | G.H3 | Y | 261 | G.H3.15 |
Hydrophobic | C-term | L | 338 | - | G.H3 | Y | 261 | G.H3.15 |
Hydrophobic | TM3 | I | 106 | 3x54 | G.H5 | L | 353 | G.H5.20 |
Polar | C-term | G | 360 | - | H.hbhc | E | 119 | H.hbhc.01 |
Hydrophobic | C-term | G | 360 | - | H.hbhc | E | 119 | H.hbhc.01 |
Van-der-waals | C-term | G | 360 | - | H.hbhc | E | 119 | H.hbhc.01 |
Hydrophobic | C-term | S | 335 | - | G.H2 | R | 214 | G.H2.05 |
Van-der-waals | C-term | S | 335 | - | G.H2 | R | 214 | G.H2.05 |
Polar | TM3 | A | 105 | 3x53 | G.H5 | N | 352 | G.H5.19 |
Van-der-waals | TM3 | A | 105 | 3x53 | G.H5 | N | 352 | G.H5.19 |
Hydrophobic | C-term | V | 334 | - | G.H3 | W | 263 | G.H3.17 |
Van-der-waals | C-term | V | 334 | - | G.H3 | W | 263 | G.H3.17 |
Hydrophobic | TM3 | I | 106 | 3x54 | G.H5 | L | 358 | G.H5.25 |
Polar | C-term | Y | 361 | - | H.HB | D | 117 | H.HB.13 |
Hydrophobic | C-term | Y | 361 | - | H.HB | D | 117 | H.HB.13 |
Van-der-waals | C-term | Y | 361 | - | H.HB | D | 117 | H.HB.13 |
Hydrophobic | TM3 | I | 106 | 3x54 | G.H5 | L | 349 | G.H5.16 |
Hydrophobic | TM5 | Q | 207 | 5x68 | G.H5 | L | 349 | G.H5.16 |
Van-der-waals | TM5 | Q | 207 | 5x68 | G.H5 | L | 349 | G.H5.16 |
Hydrophobic | ICL2 | G | 114 | 34x55 | G.hns1 | R | 38 | G.hns1.03 |
Hydrophobic | ICL2 | L | 110 | 34x51 | G.S1 | L | 40 | G.S1.02 |
Van-der-waals | ICL2 | L | 110 | 34x51 | G.S1 | L | 40 | G.S1.02 |
Polar | C-term | S | 320 | - | G.h3s5 | Q | 265 | G.h3s5.01 |
Van-der-waals | C-term | S | 320 | - | G.h3s5 | Q | 265 | G.h3s5.01 |
Hydrophobic | ICL3 | L | 216 | - | G.H4 | V | 314 | G.H4.16 |
Van-der-waals | ICL3 | L | 216 | - | G.H4 | V | 314 | G.H4.16 |
Van-der-waals | ICL2 | N | 113 | 34x54 | G.hns1 | R | 37 | G.hns1.02 |
Polar | C-term | Y | 361 | - | H.hbhc | K | 120 | H.hbhc.02 |
Hydrophobic | C-term | Y | 361 | - | H.hbhc | K | 120 | H.hbhc.02 |
Van-der-waals | C-term | Y | 361 | - | H.hbhc | K | 120 | H.hbhc.02 |
Hydrophobic | C-term | L | 338 | - | G.h2s4 | F | 220 | G.h2s4.01 |
Hydrophobic | TM5 | Q | 207 | 5x68 | G.H5 | Q | 350 | G.H5.17 |
Van-der-waals | TM5 | Q | 207 | 5x68 | G.H5 | Q | 350 | G.H5.17 |
Hydrophobic | ICL2 | R | 111 | 34x52 | G.S3 | I | 199 | G.S3.01 |
Hydrophobic | TM5 | I | 200 | 5x61 | G.H5 | L | 358 | G.H5.25 |
Van-der-waals | TM5 | I | 200 | 5x61 | G.H5 | L | 358 | G.H5.25 |
Polar | ICL2 | R | 111 | 34x52 | G.s2s3 | E | 197 | G.s2s3.01 |
Hydrophobic | ICL2 | R | 111 | 34x52 | G.s2s3 | E | 197 | G.s2s3.01 |
Van-der-waals | ICL2 | R | 111 | 34x52 | G.s2s3 | E | 197 | G.s2s3.01 |
Hydrophobic | ICL2 | P | 109 | 34x50 | G.H5 | K | 345 | G.H5.12 |
Hydrophobic | ICL2 | L | 110 | 34x51 | G.H5 | I | 348 | G.H5.15 |
Van-der-waals | ICL2 | L | 110 | 34x51 | G.H5 | I | 348 | G.H5.15 |
Hydrophobic | C-term | L | 324 | - | G.H3 | W | 263 | G.H3.17 |
Hydrophobic | TM6 | S | 234 | 6x36 | G.H5 | L | 358 | G.H5.25 |
Hydrophobic | TM6 | A | 231 | 6x33 | G.H5 | L | 358 | G.H5.25 |
Van-der-waals | TM6 | A | 231 | 6x33 | G.H5 | L | 358 | G.H5.25 |
Hydrophobic | TM3 | A | 105 | 3x53 | G.H5 | Y | 356 | G.H5.23 |
Van-der-waals | TM3 | A | 105 | 3x53 | G.H5 | Y | 356 | G.H5.23 |
Polar | C-term | N | 339 | - | G.H2 | R | 210 | G.H2.01 |
Hydrophobic | C-term | N | 339 | - | G.H2 | R | 210 | G.H2.01 |
Van-der-waals | C-term | N | 339 | - | G.H2 | R | 210 | G.H2.01 |
Hydrophobic | C-term | R | 337 | - | G.H3 | T | 257 | G.H3.11 |
Polar | TM6 | E | 219 | 6x21 | G.h4s6 | S | 320 | G.h4s6.11 |
Hydrophobic | TM6 | E | 219 | 6x21 | G.h4s6 | S | 320 | G.h4s6.11 |
Van-der-waals | TM6 | E | 219 | 6x21 | G.h4s6 | S | 320 | G.h4s6.11 |
Hydrophobic | ICL2 | L | 110 | 34x51 | G.H5 | V | 344 | G.H5.11 |
Polar | C-term | V | 334 | - | G.H3 | Y | 261 | G.H3.15 |
Hydrophobic | C-term | V | 334 | - | G.H3 | Y | 261 | G.H3.15 |
Van-der-waals | C-term | V | 334 | - | G.H3 | Y | 261 | G.H3.15 |
Hydrophobic | C-term | L | 324 | - | G.H3 | P | 262 | G.H3.16 |
Van-der-waals | C-term | L | 324 | - | G.H3 | P | 262 | G.H3.16 |
Hydrophobic | C-term | V | 334 | - | G.h2s4 | F | 220 | G.h2s4.01 |
Polar | C-term | L | 338 | - | G.H2 | R | 213 | G.H2.04 |
Hydrophobic | C-term | L | 338 | - | G.H2 | R | 213 | G.H2.04 |
Van-der-waals | C-term | L | 338 | - | G.H2 | R | 213 | G.H2.04 |
Hydrophobic | TM3 | I | 106 | 3x54 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | C-term | L | 338 | - | G.H3 | I | 258 | G.H3.12 |
Hydrophobic | C-term | L | 338 | - | G.H3 | L | 254 | G.H3.08 |
Van-der-waals | C-term | L | 338 | - | G.H3 | L | 254 | G.H3.08 |
Hydrophobic | C-term | V | 334 | - | G.H2 | I | 217 | G.H2.08 |
Hydrophobic | C-term | G | 331 | - | G.H2 | I | 217 | G.H2.08 |
Van-der-waals | C-term | G | 331 | - | G.H2 | I | 217 | G.H2.08 |
Hydrophobic | TM6 | L | 235 | 6x37 | G.H5 | L | 358 | G.H5.25 |
Van-der-waals | TM6 | L | 235 | 6x37 | G.H5 | L | 358 | G.H5.25 |
Hydrophobic | TM5 | M | 211 | 5x72 | G.h4s6 | I | 323 | G.h4s6.20 |
Van-der-waals | TM5 | M | 211 | 5x72 | G.h4s6 | I | 323 | G.h4s6.20 |
Hydrophobic | TM5 | L | 208 | 5x69 | G.H5 | V | 359 | G.H5.26 |
Hydrophobic | TM5 | Q | 207 | 5x68 | G.H5 | L | 353 | G.H5.20 |
Van-der-waals | TM5 | Q | 207 | 5x68 | G.H5 | L | 353 | G.H5.20 |
Hydrophobic | ICL2 | L | 110 | 34x51 | G.S3 | I | 199 | G.S3.01 |
Van-der-waals | ICL2 | L | 110 | 34x51 | G.S3 | I | 199 | G.S3.01 |
Polar | TM7 | R | 291 | 7x56 | G.H5 | N | 357 | G.H5.24 |
Hydrophobic | TM7 | R | 291 | 7x56 | G.H5 | N | 357 | G.H5.24 |
Van-der-waals | TM7 | R | 291 | 7x56 | G.H5 | N | 357 | G.H5.24 |
Polar | TM6 | H | 230 | 6x32 | G.H5 | N | 357 | G.H5.24 |
Hydrophobic | ICL2 | R | 111 | 34x52 | G.s2s3 | N | 198 | G.s2s3.02 |
Hydrophobic | C-term | L | 338 | - | G.H3 | T | 257 | G.H3.11 |
Polar | TM3 | R | 102 | 3x50 | G.H5 | Y | 356 | G.H5.23 |
Aromatic | TM3 | R | 102 | 3x50 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | TM3 | R | 102 | 3x50 | G.H5 | Y | 356 | G.H5.23 |
Van-der-waals | TM3 | R | 102 | 3x50 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | ICL2 | L | 110 | 34x51 | G.H5 | K | 345 | G.H5.12 |
Hydrophobic | ICL2 | P | 109 | 34x50 | G.H5 | I | 348 | G.H5.15 |
Van-der-waals | ICL2 | P | 109 | 34x50 | G.H5 | I | 348 | G.H5.15 |
Hydrophobic | C-term | L | 338 | - | G.H2 | W | 216 | G.H2.07 |
Hydrophobic | ICL2 | L | 110 | 34x51 | G.H5 | F | 341 | G.H5.08 |
Van-der-waals | ICL2 | L | 110 | 34x51 | G.H5 | F | 341 | G.H5.08 |