Gi3 - A3 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 88.7

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.8
PAE mean: 11.9


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar TM6 S 231 6x36 G.H5 G 352 G.H5.24
Ionic TM6 R 224 6x29 G.h4s6 E 318 G.h4s6.12
Polar TM6 R 224 6x29 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM3 R 108 3x50 G.H5 L 353 G.H5.25
Polar TM5 N 211 5x72 G.H5 D 341 G.H5.13
Van-der-waals TM5 N 211 5x72 G.H5 D 341 G.H5.13
Hydrophobic TM5 I 200 5x61 G.H5 L 353 G.H5.25
Hydrophobic TM6 A 220 6x25 G.h4s6 D 315 G.h4s6.09
Polar TM3 R 111 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 R 111 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 R 111 3x53 G.H5 N 347 G.H5.19
Polar TM3 R 108 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 108 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 108 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM5 I 204 5x65 G.H5 L 348 G.H5.20
Van-der-waals TM5 I 204 5x65 G.H5 L 348 G.H5.20
Polar TM5 N 211 5x72 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM5 N 211 5x72 G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL2 V 116 34x51 G.S3 L 194 G.S3.01
Van-der-waals ICL2 V 116 34x51 G.S3 L 194 G.S3.01
Hydrophobic H8 I 286 8x47 G.H5 C 351 G.H5.23
Hydrophobic ICL2 V 116 34x51 G.H5 I 343 G.H5.15
Hydrophobic TM6 L 232 6x37 G.H5 L 353 G.H5.25
Van-der-waals TM6 L 232 6x37 G.H5 L 353 G.H5.25
Polar TM6 K 227 6x32 G.H5 Y 354 G.H5.26
Hydrophobic TM6 K 227 6x32 G.H5 Y 354 G.H5.26
Van-der-waals TM6 K 227 6x32 G.H5 Y 354 G.H5.26
Van-der-waals H8 I 286 8x47 G.H5 E 350 G.H5.22
Hydrophobic ICL2 R 117 34x52 G.s2s3 D 193 G.s2s3.02
Hydrophobic ICL2 V 116 34x51 G.s2s3 D 193 G.s2s3.02
Ionic TM5 K 207 5x68 G.H5 D 341 G.H5.13
Polar TM5 K 207 5x68 G.H5 D 341 G.H5.13
Van-der-waals TM5 K 207 5x68 G.H5 D 341 G.H5.13
Polar TM5 N 211 5x72 G.S6 Y 320 G.S6.02
Hydrophobic TM5 N 211 5x72 G.S6 Y 320 G.S6.02
Ionic H8 K 287 8x48 G.h3s5 E 261 G.h3s5.02
Polar H8 K 287 8x48 G.h3s5 E 261 G.h3s5.02
Van-der-waals H8 K 287 8x48 G.h3s5 E 261 G.h3s5.02
Hydrophobic TM7 K 285 7x56 G.H5 G 352 G.H5.24
Polar ICL2 T 115 34x50 G.H5 N 347 G.H5.19
Hydrophobic ICL2 T 115 34x50 G.H5 I 344 G.H5.16
Van-der-waals ICL2 T 115 34x50 G.H5 I 344 G.H5.16
Polar TM6 T 228 6x33 G.H5 L 353 G.H5.25
Polar ICL2 K 119 34x54 G.hns1 K 32 G.hns1.03
Hydrophobic ICL2 K 119 34x54 G.hns1 K 32 G.hns1.03
Van-der-waals ICL2 K 119 34x54 G.hns1 K 32 G.hns1.03
Hydrophobic H8 I 286 8x47 G.H5 G 352 G.H5.24
Hydrophobic TM3 V 112 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 V 112 3x54 G.H5 L 348 G.H5.20
Hydrophobic ICL2 R 120 34x55 G.hns1 K 32 G.hns1.03
Ionic ICL2 R 120 34x55 G.s2s3 D 193 G.s2s3.02
Polar ICL2 R 120 34x55 G.s2s3 D 193 G.s2s3.02
Van-der-waals ICL2 R 120 34x55 G.s2s3 D 193 G.s2s3.02
Hydrophobic TM5 K 207 5x68 G.H5 I 344 G.H5.16
Van-der-waals TM5 K 207 5x68 G.H5 I 344 G.H5.16
Hydrophobic TM6 S 231 6x36 G.H5 L 353 G.H5.25
Polar TM6 R 224 6x29 G.H5 Y 354 G.H5.26
Hydrophobic TM6 R 224 6x29 G.H5 Y 354 G.H5.26
Van-der-waals TM6 R 224 6x29 G.H5 Y 354 G.H5.26
Hydrophobic TM3 R 111 3x53 G.H5 C 351 G.H5.23
Hydrophobic ICL2 T 115 34x50 G.H5 I 343 G.H5.15
Van-der-waals ICL2 T 115 34x50 G.H5 I 343 G.H5.15
Ionic TM6 E 217 6x22 G.h4s6 K 314 G.h4s6.08
Hydrophobic TM6 E 217 6x22 G.h4s6 K 314 G.h4s6.08
Van-der-waals TM6 E 217 6x22 G.h4s6 K 314 G.h4s6.08
Polar ICL2 K 119 34x54 G.hns1 A 31 G.hns1.02
Hydrophobic ICL2 K 119 34x54 G.hns1 A 31 G.hns1.02
Van-der-waals ICL2 K 119 34x54 G.hns1 A 31 G.hns1.02
Ionic TM3 R 111 3x53 G.H5 E 350 G.H5.22
Polar TM3 R 111 3x53 G.H5 E 350 G.H5.22
Van-der-waals TM3 R 111 3x53 G.H5 E 350 G.H5.22