GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 75.4
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.5
iPTM Score: 0.3
PAE mean: 23.3
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Polar | TM3 | K | 142 | 3x50 | G.H5 | I | 378 | G.H5.23 |
Van-der-waals | TM3 | K | 142 | 3x50 | G.H5 | I | 378 | G.H5.23 |
Polar | ICL2 | L | 155 | 34x56 | G.hns1 | R | 55 | G.hns1.02 |
Hydrophobic | ICL2 | L | 155 | 34x56 | G.hns1 | R | 55 | G.hns1.02 |
Van-der-waals | ICL2 | L | 155 | 34x56 | G.hns1 | R | 55 | G.hns1.02 |
Hydrophobic | ECL2 | F | 199 | - | G.HN | T | 7 | G.HN.07 |
Polar | TM7 | E | 298 | 7x38 | G.HN | M | 1 | G.HN.01 |
Hydrophobic | TM7 | E | 298 | 7x38 | G.HN | M | 1 | G.HN.01 |
Van-der-waals | TM7 | E | 298 | 7x38 | G.HN | M | 1 | G.HN.01 |
Polar | ICL3 | R | 241 | - | G.H5 | Q | 372 | G.H5.17 |
Van-der-waals | ICL3 | R | 241 | - | G.H5 | Q | 372 | G.H5.17 |
Hydrophobic | TM5 | T | 204 | 5x33 | G.HN | T | 7 | G.HN.07 |
Van-der-waals | TM5 | T | 204 | 5x33 | G.HN | T | 7 | G.HN.07 |
Hydrophobic | TM5 | L | 237 | 5x65 | G.H5 | M | 379 | G.H5.24 |
Van-der-waals | TM5 | L | 237 | 5x65 | G.H5 | M | 379 | G.H5.24 |
Hydrophobic | ICL2 | P | 151 | 34x52 | G.S1 | L | 57 | G.S1.01 |
Ionic | ICL2 | H | 153 | 34x54 | G.h2s4 | D | 243 | G.h2s4.02 |
Polar | ICL2 | H | 153 | 34x54 | G.h2s4 | D | 243 | G.h2s4.02 |
Hydrophobic | ICL2 | H | 153 | 34x54 | G.h2s4 | D | 243 | G.h2s4.02 |
Van-der-waals | ICL2 | H | 153 | 34x54 | G.h2s4 | D | 243 | G.h2s4.02 |
Hydrophobic | TM5 | L | 240 | 5x68 | G.S3 | I | 221 | G.S3.01 |
Hydrophobic | TM1 | K | 38 | 1x24 | G.HN | V | 4 | G.HN.04 |
Polar | ICL2 | Y | 152 | 34x53 | G.H5 | Q | 381 | G.H5.26 |
Hydrophobic | ICL2 | Y | 152 | 34x53 | G.H5 | Q | 381 | G.H5.26 |
Van-der-waals | ICL2 | Y | 152 | 34x53 | G.H5 | Q | 381 | G.H5.26 |
Polar | C-term | I | 352 | - | G.H2 | Q | 236 | G.H2.05 |
Van-der-waals | C-term | I | 352 | - | G.H2 | Q | 236 | G.H2.05 |
Hydrophobic | TM1 | Y | 53 | 1x39 | G.HN | M | 1 | G.HN.01 |
Hydrophobic | TM7 | F | 302 | 7x42 | G.HN | M | 1 | G.HN.01 |
Van-der-waals | TM7 | F | 302 | 7x42 | G.HN | M | 1 | G.HN.01 |
Hydrophobic | TM5 | L | 237 | 5x65 | G.H5 | L | 375 | G.H5.20 |
Hydrophobic | C-term | M | 362 | - | H.HA | K | 114 | H.HA.28 |
Van-der-waals | C-term | M | 362 | - | H.HA | K | 114 | H.HA.28 |
Hydrophobic | TM3 | I | 146 | 3x54 | G.H5 | L | 375 | G.H5.20 |
Van-der-waals | TM3 | I | 146 | 3x54 | G.H5 | L | 375 | G.H5.20 |
Polar | TM6 | A | 243 | 6x28 | G.H5 | Q | 372 | G.H5.17 |
Hydrophobic | TM6 | A | 243 | 6x28 | G.H5 | Q | 372 | G.H5.17 |
Van-der-waals | TM6 | A | 243 | 6x28 | G.H5 | Q | 372 | G.H5.17 |
Hydrophobic | TM5 | L | 240 | 5x68 | G.H5 | L | 375 | G.H5.20 |
Van-der-waals | TM5 | L | 240 | 5x68 | G.H5 | L | 375 | G.H5.20 |
Hydrophobic | TM2 | W | 102 | 2x60 | G.HN | M | 1 | G.HN.01 |
Van-der-waals | TM2 | W | 102 | 2x60 | G.HN | M | 1 | G.HN.01 |
Hydrophobic | N-term | L | 35 | - | G.HN | R | 6 | G.HN.06 |
Van-der-waals | N-term | L | 35 | - | G.HN | R | 6 | G.HN.06 |
Hydrophobic | ICL3 | P | 242 | - | G.H5 | L | 375 | G.H5.20 |
Polar | TM5 | T | 204 | 5x33 | G.HN | L | 8 | G.HN.08 |
Hydrophobic | TM5 | T | 204 | 5x33 | G.HN | L | 8 | G.HN.08 |
Van-der-waals | TM5 | T | 204 | 5x33 | G.HN | L | 8 | G.HN.08 |
Polar | C-term | S | 343 | - | G.H3 | K | 284 | G.H3.16 |
Van-der-waals | C-term | S | 343 | - | G.H3 | K | 284 | G.H3.16 |
Hydrophobic | TM3 | I | 146 | 3x54 | G.H5 | M | 379 | G.H5.24 |
Van-der-waals | TM3 | I | 146 | 3x54 | G.H5 | M | 379 | G.H5.24 |
Polar | TM6 | D | 277 | 6x62 | G.HN | T | 7 | G.HN.07 |
Hydrophobic | TM6 | D | 277 | 6x62 | G.HN | T | 7 | G.HN.07 |
Van-der-waals | TM6 | D | 277 | 6x62 | G.HN | T | 7 | G.HN.07 |
Hydrophobic | TM6 | A | 248 | 6x33 | G.H5 | M | 379 | G.H5.24 |
Van-der-waals | TM6 | A | 248 | 6x33 | G.H5 | M | 379 | G.H5.24 |
Polar | C-term | A | 342 | - | G.H3 | K | 284 | G.H3.16 |
Hydrophobic | C-term | A | 342 | - | G.H3 | K | 284 | G.H3.16 |
Van-der-waals | C-term | A | 342 | - | G.H3 | K | 284 | G.H3.16 |
Hydrophobic | TM6 | L | 278 | 6x63 | G.HN | S | 9 | G.HN.09 |
Hydrophobic | ECL2 | H | 196 | 45x51 | G.HN | V | 5 | G.HN.05 |
Polar | H8 | S | 316 | 8x47 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | H8 | S | 316 | 8x47 | G.H5 | L | 380 | G.H5.25 |
Van-der-waals | H8 | S | 316 | 8x47 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | TM5 | I | 205 | 5x34 | G.HN | L | 12 | G.HN.12 |
Hydrophobic | H8 | R | 318 | 8x49 | G.H5 | Q | 381 | G.H5.26 |
Polar | ICL2 | A | 149 | 34x50 | G.S1 | L | 57 | G.S1.01 |
Hydrophobic | TM3 | I | 146 | 3x54 | G.H5 | I | 378 | G.H5.23 |
Van-der-waals | TM3 | I | 146 | 3x54 | G.H5 | I | 378 | G.H5.23 |
Polar | TM6 | Q | 279 | 6x64 | G.HN | S | 9 | G.HN.09 |
Hydrophobic | TM6 | Q | 279 | 6x64 | G.HN | S | 9 | G.HN.09 |
Van-der-waals | TM6 | Q | 279 | 6x64 | G.HN | S | 9 | G.HN.09 |
Hydrophobic | C-term | M | 359 | - | G.s4h3 | M | 262 | G.s4h3.09 |
Van-der-waals | C-term | M | 359 | - | G.s4h3 | M | 262 | G.s4h3.09 |
Hydrophobic | TM7 | D | 291 | 7x31 | G.HN | V | 4 | G.HN.04 |
Van-der-waals | TM7 | D | 291 | 7x31 | G.HN | V | 4 | G.HN.04 |
Polar | TM3 | V | 147 | 3x55 | G.hns1 | R | 56 | G.hns1.03 |
Hydrophobic | TM3 | V | 147 | 3x55 | G.hns1 | R | 56 | G.hns1.03 |
Van-der-waals | TM3 | V | 147 | 3x55 | G.hns1 | R | 56 | G.hns1.03 |
Hydrophobic | TM5 | L | 240 | 5x68 | G.H5 | L | 371 | G.H5.16 |
Van-der-waals | TM5 | L | 240 | 5x68 | G.H5 | L | 371 | G.H5.16 |
Ionic | TM3 | D | 141 | 3x49 | G.hns1 | R | 55 | G.hns1.02 |
Polar | TM3 | D | 141 | 3x49 | G.hns1 | R | 55 | G.hns1.02 |
Hydrophobic | TM2 | V | 81 | 2x39 | G.H5 | Q | 381 | G.H5.26 |
Polar | ICL2 | H | 153 | 34x54 | G.h2s4 | G | 244 | G.h2s4.03 |
Hydrophobic | ICL2 | H | 153 | 34x54 | G.h2s4 | G | 244 | G.h2s4.03 |
Van-der-waals | ICL2 | H | 153 | 34x54 | G.h2s4 | G | 244 | G.h2s4.03 |
Polar | TM3 | Y | 124 | 3x32 | G.HN | M | 1 | G.HN.01 |
Hydrophobic | TM3 | Y | 124 | 3x32 | G.HN | M | 1 | G.HN.01 |
Van-der-waals | TM3 | Y | 124 | 3x32 | G.HN | M | 1 | G.HN.01 |
Polar | H8 | S | 316 | 8x47 | G.H5 | Q | 381 | G.H5.26 |
Hydrophobic | H8 | S | 316 | 8x47 | G.H5 | Q | 381 | G.H5.26 |
Van-der-waals | H8 | S | 316 | 8x47 | G.H5 | Q | 381 | G.H5.26 |
Polar | H8 | H | 317 | 8x48 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | H8 | H | 317 | 8x48 | G.H5 | L | 380 | G.H5.25 |
Van-der-waals | H8 | H | 317 | 8x48 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | ICL2 | A | 149 | 34x50 | G.hns1 | R | 56 | G.hns1.03 |
Van-der-waals | ICL2 | A | 149 | 34x50 | G.hns1 | R | 56 | G.hns1.03 |
Van-der-waals | ICL2 | Q | 150 | 34x51 | G.HN | R | 52 | G.HN.52 |
Ionic | TM2 | R | 79 | 2x37 | G.H5 | D | 377 | G.H5.22 |
Polar | H8 | R | 318 | 8x49 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | C-term | L | 365 | - | H.HA | K | 114 | H.HA.28 |
Polar | TM5 | R | 211 | 5x40 | G.HN | S | 2 | G.HN.02 |
Hydrophobic | ICL2 | P | 151 | 34x52 | G.hns1 | V | 54 | G.hns1.01 |
Van-der-waals | ICL2 | P | 151 | 34x52 | G.hns1 | V | 54 | G.hns1.01 |
Polar | TM5 | K | 207 | 5x36 | G.HN | T | 7 | G.HN.07 |
Hydrophobic | TM5 | K | 207 | 5x36 | G.HN | T | 7 | G.HN.07 |
Van-der-waals | TM5 | K | 207 | 5x36 | G.HN | T | 7 | G.HN.07 |
Polar | TM3 | K | 142 | 3x50 | G.H5 | Q | 381 | G.H5.26 |
Van-der-waals | TM3 | K | 142 | 3x50 | G.H5 | Q | 381 | G.H5.26 |
Polar | TM2 | R | 79 | 2x37 | G.H5 | Q | 381 | G.H5.26 |
Hydrophobic | TM2 | R | 79 | 2x37 | G.H5 | Q | 381 | G.H5.26 |
Van-der-waals | TM2 | R | 79 | 2x37 | G.H5 | Q | 381 | G.H5.26 |
Polar | TM3 | H | 148 | 3x56 | G.hns1 | R | 56 | G.hns1.03 |
Hydrophobic | TM3 | H | 148 | 3x56 | G.hns1 | R | 56 | G.hns1.03 |
Van-der-waals | TM3 | H | 148 | 3x56 | G.hns1 | R | 56 | G.hns1.03 |
Polar | TM3 | H | 148 | 3x56 | G.HN | R | 52 | G.HN.52 |
Aromatic | TM3 | H | 148 | 3x56 | G.HN | R | 52 | G.HN.52 |
Hydrophobic | TM3 | H | 148 | 3x56 | G.HN | R | 52 | G.HN.52 |
Van-der-waals | TM3 | H | 148 | 3x56 | G.HN | R | 52 | G.HN.52 |
Hydrophobic | TM3 | H | 148 | 3x56 | G.hns1 | R | 55 | G.hns1.02 |
Van-der-waals | TM3 | H | 148 | 3x56 | G.hns1 | R | 55 | G.hns1.02 |
Hydrophobic | ICL2 | L | 155 | 34x56 | G.HN | R | 51 | G.HN.51 |
Van-der-waals | ICL2 | L | 155 | 34x56 | G.HN | R | 51 | G.HN.51 |
Polar | H8 | R | 318 | 8x49 | G.h3s5 | N | 288 | G.h3s5.02 |
Hydrophobic | H8 | R | 318 | 8x49 | G.h3s5 | N | 288 | G.h3s5.02 |
Van-der-waals | H8 | R | 318 | 8x49 | G.h3s5 | N | 288 | G.h3s5.02 |
Polar | TM6 | D | 277 | 6x62 | G.HN | S | 9 | G.HN.09 |
Van-der-waals | TM6 | D | 277 | 6x62 | G.HN | S | 9 | G.HN.09 |
Polar | TM3 | E | 145 | 3x53 | G.H5 | Q | 381 | G.H5.26 |
Hydrophobic | TM3 | E | 145 | 3x53 | G.H5 | I | 378 | G.H5.23 |
Van-der-waals | TM3 | E | 145 | 3x53 | G.H5 | I | 378 | G.H5.23 |
Hydrophobic | ICL3 | P | 242 | - | G.H5 | Q | 372 | G.H5.17 |
Van-der-waals | ICL3 | P | 242 | - | G.H5 | Q | 372 | G.H5.17 |
Polar | TM6 | A | 243 | 6x28 | G.H5 | K | 376 | G.H5.21 |
Hydrophobic | TM6 | A | 243 | 6x28 | G.H5 | K | 376 | G.H5.21 |
Van-der-waals | TM6 | A | 243 | 6x28 | G.H5 | K | 376 | G.H5.21 |
Polar | TM5 | K | 207 | 5x36 | G.HN | V | 5 | G.HN.05 |
Hydrophobic | TM5 | K | 207 | 5x36 | G.HN | V | 5 | G.HN.05 |
Van-der-waals | TM5 | K | 207 | 5x36 | G.HN | V | 5 | G.HN.05 |
Ionic | H8 | R | 318 | 8x49 | G.H5 | D | 377 | G.H5.22 |
Polar | H8 | R | 318 | 8x49 | G.H5 | D | 377 | G.H5.22 |
Hydrophobic | H8 | R | 318 | 8x49 | G.H5 | D | 377 | G.H5.22 |
Van-der-waals | H8 | R | 318 | 8x49 | G.H5 | D | 377 | G.H5.22 |
Hydrophobic | ICL2 | A | 149 | 34x50 | G.hns1 | R | 55 | G.hns1.02 |
Van-der-waals | ICL2 | A | 149 | 34x50 | G.hns1 | R | 55 | G.hns1.02 |
Hydrophobic | ICL2 | R | 156 | 34x57 | G.hns1 | R | 55 | G.hns1.02 |
Van-der-waals | ICL2 | R | 156 | 34x57 | G.hns1 | R | 55 | G.hns1.02 |
Polar | ICL2 | Q | 150 | 34x51 | G.hns1 | R | 55 | G.hns1.02 |
Hydrophobic | ICL2 | Q | 150 | 34x51 | G.hns1 | R | 55 | G.hns1.02 |
Van-der-waals | ICL2 | Q | 150 | 34x51 | G.hns1 | R | 55 | G.hns1.02 |
Hydrophobic | ECL2 | H | 196 | 45x51 | G.HN | G | 3 | G.HN.03 |
Hydrophobic | ECL2 | A | 197 | 45x52 | G.HN | V | 5 | G.HN.05 |
Van-der-waals | ECL2 | A | 197 | 45x52 | G.HN | V | 5 | G.HN.05 |
Polar | ICL2 | P | 151 | 34x52 | G.hns1 | R | 55 | G.hns1.02 |
Hydrophobic | ICL2 | P | 151 | 34x52 | G.hns1 | R | 55 | G.hns1.02 |
Van-der-waals | ICL2 | P | 151 | 34x52 | G.hns1 | R | 55 | G.hns1.02 |
Polar | ICL2 | Q | 150 | 34x51 | G.HN | R | 51 | G.HN.51 |
Van-der-waals | ICL2 | Q | 150 | 34x51 | G.HN | R | 51 | G.HN.51 |