GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 80.0
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.7
iPTM Score: 0.5
PAE mean: 15.8
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | TM3 | K | 142 | 3x50 | G.H5 | Y | 378 | G.H5.23 |
Van-der-waals | TM3 | K | 142 | 3x50 | G.H5 | Y | 378 | G.H5.23 |
Hydrophobic | ICL2 | P | 151 | 34x52 | G.H5 | H | 374 | G.H5.19 |
Polar | ICL2 | Y | 152 | 34x53 | G.H5 | Q | 377 | G.H5.22 |
Hydrophobic | ICL2 | Y | 152 | 34x53 | G.H5 | Q | 377 | G.H5.22 |
Van-der-waals | ICL2 | Y | 152 | 34x53 | G.H5 | Q | 377 | G.H5.22 |
Hydrophobic | ICL2 | Y | 152 | 34x53 | G.H5 | Y | 378 | G.H5.23 |
Hydrophobic | ICL2 | Q | 150 | 34x51 | G.S1 | H | 43 | G.S1.02 |
Hydrophobic | ICL2 | A | 149 | 34x50 | G.H5 | Q | 371 | G.H5.16 |
Polar | ICL2 | R | 154 | 34x55 | G.hns1 | Y | 39 | G.hns1.01 |
Hydrophobic | ICL2 | R | 154 | 34x55 | G.hns1 | Y | 39 | G.hns1.01 |
Van-der-waals | ICL2 | R | 154 | 34x55 | G.hns1 | Y | 39 | G.hns1.01 |
Polar | TM3 | V | 147 | 3x55 | G.H5 | Q | 371 | G.H5.16 |
Van-der-waals | TM3 | V | 147 | 3x55 | G.H5 | Q | 371 | G.H5.16 |
Hydrophobic | ICL2 | H | 153 | 34x54 | G.h3s5 | I | 272 | G.h3s5.03 |
Van-der-waals | ICL2 | H | 153 | 34x54 | G.h3s5 | I | 272 | G.h3s5.03 |
Polar | ICL2 | L | 155 | 34x56 | G.hns1 | K | 40 | G.hns1.02 |
Polar | ICL2 | A | 149 | 34x50 | G.S1 | H | 43 | G.S1.02 |
Hydrophobic | ICL2 | A | 149 | 34x50 | G.S1 | H | 43 | G.S1.02 |
Van-der-waals | ICL2 | A | 149 | 34x50 | G.S1 | H | 43 | G.S1.02 |
Polar | H8 | S | 316 | 8x47 | G.H5 | E | 379 | G.H5.24 |
Hydrophobic | H8 | S | 316 | 8x47 | G.H5 | E | 379 | G.H5.24 |
Van-der-waals | H8 | S | 316 | 8x47 | G.H5 | E | 379 | G.H5.24 |
Polar | TM2 | R | 79 | 2x37 | G.H5 | Q | 377 | G.H5.22 |
Hydrophobic | TM2 | R | 79 | 2x37 | G.H5 | Q | 377 | G.H5.22 |
Van-der-waals | TM2 | R | 79 | 2x37 | G.H5 | Q | 377 | G.H5.22 |
Polar | TM3 | I | 146 | 3x54 | G.H5 | Q | 371 | G.H5.16 |
Van-der-waals | TM3 | I | 146 | 3x54 | G.H5 | Q | 371 | G.H5.16 |
Hydrophobic | TM3 | I | 146 | 3x54 | G.H5 | Y | 378 | G.H5.23 |
Hydrophobic | TM6 | A | 243 | 6x28 | G.H5 | L | 381 | G.H5.26 |
Van-der-waals | TM6 | A | 243 | 6x28 | G.H5 | L | 381 | G.H5.26 |
Hydrophobic | TM6 | Q | 245 | 6x30 | G.H5 | L | 381 | G.H5.26 |
Hydrophobic | ICL2 | H | 153 | 34x54 | G.h2s4 | T | 229 | G.h2s4.05 |
Polar | TM3 | E | 145 | 3x53 | G.H5 | Y | 378 | G.H5.23 |
Hydrophobic | TM3 | E | 145 | 3x53 | G.H5 | Y | 378 | G.H5.23 |
Van-der-waals | TM3 | E | 145 | 3x53 | G.H5 | Y | 378 | G.H5.23 |
Polar | ICL2 | P | 151 | 34x52 | G.S1 | H | 43 | G.S1.02 |
Hydrophobic | ICL2 | P | 151 | 34x52 | G.S1 | H | 43 | G.S1.02 |
Van-der-waals | ICL2 | P | 151 | 34x52 | G.S1 | H | 43 | G.S1.02 |
Hydrophobic | TM5 | V | 236 | 5x64 | G.H5 | Q | 371 | G.H5.16 |
Van-der-waals | TM5 | V | 236 | 5x64 | G.H5 | Q | 371 | G.H5.16 |
Polar | ICL2 | Q | 150 | 34x51 | G.H5 | H | 374 | G.H5.19 |
Hydrophobic | ICL2 | Q | 150 | 34x51 | G.H5 | H | 374 | G.H5.19 |
Van-der-waals | ICL2 | Q | 150 | 34x51 | G.H5 | H | 374 | G.H5.19 |
Hydrophobic | TM5 | I | 233 | 5x61 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | ICL3 | P | 242 | - | G.H5 | L | 381 | G.H5.26 |
Van-der-waals | ICL3 | P | 242 | - | G.H5 | L | 381 | G.H5.26 |
Hydrophobic | ICL2 | P | 151 | 34x52 | G.hns1 | K | 40 | G.hns1.02 |
Van-der-waals | ICL2 | P | 151 | 34x52 | G.hns1 | K | 40 | G.hns1.02 |
Hydrophobic | TM5 | L | 237 | 5x65 | G.H5 | L | 375 | G.H5.20 |
Van-der-waals | TM5 | L | 237 | 5x65 | G.H5 | L | 375 | G.H5.20 |
Ionic | TM5 | R | 239 | 5x67 | G.H5 | D | 368 | G.H5.13 |
Polar | TM5 | R | 239 | 5x67 | G.H5 | D | 368 | G.H5.13 |
Van-der-waals | TM5 | R | 239 | 5x67 | G.H5 | D | 368 | G.H5.13 |
Hydrophobic | TM3 | I | 146 | 3x54 | G.H5 | L | 380 | G.H5.25 |
Van-der-waals | TM3 | I | 146 | 3x54 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | TM3 | I | 146 | 3x54 | G.H5 | L | 375 | G.H5.20 |
Van-der-waals | TM3 | I | 146 | 3x54 | G.H5 | L | 375 | G.H5.20 |
Hydrophobic | C-term | M | 362 | - | G.H2 | R | 218 | G.H2.04 |
Polar | ICL2 | R | 154 | 34x55 | G.HN | R | 36 | G.HN.51 |
Van-der-waals | ICL2 | R | 154 | 34x55 | G.HN | R | 36 | G.HN.51 |
Hydrophobic | C-term | M | 362 | - | G.H2 | R | 219 | G.H2.05 |
Van-der-waals | C-term | M | 362 | - | G.H2 | R | 219 | G.H2.05 |
Hydrophobic | ICL2 | P | 151 | 34x52 | G.hns1 | A | 41 | G.hns1.03 |
Van-der-waals | ICL2 | P | 151 | 34x52 | G.hns1 | A | 41 | G.hns1.03 |
Hydrophobic | TM5 | L | 240 | 5x68 | G.H5 | Q | 371 | G.H5.16 |
Van-der-waals | TM5 | L | 240 | 5x68 | G.H5 | Q | 371 | G.H5.16 |
Hydrophobic | TM5 | L | 240 | 5x68 | G.H5 | L | 375 | G.H5.20 |
Van-der-waals | TM5 | L | 240 | 5x68 | G.H5 | L | 375 | G.H5.20 |
Hydrophobic | ICL2 | Y | 152 | 34x53 | G.H5 | H | 374 | G.H5.19 |
Van-der-waals | ICL2 | Y | 152 | 34x53 | G.H5 | H | 374 | G.H5.19 |
Hydrophobic | TM5 | L | 237 | 5x65 | G.H5 | L | 381 | G.H5.26 |
Hydrophobic | ICL2 | A | 149 | 34x50 | G.H5 | I | 370 | G.H5.15 |
Ionic | TM3 | E | 145 | 3x53 | G.H5 | H | 374 | G.H5.19 |
Polar | TM3 | E | 145 | 3x53 | G.H5 | H | 374 | G.H5.19 |
Hydrophobic | TM3 | E | 145 | 3x53 | G.H5 | H | 374 | G.H5.19 |
Van-der-waals | TM3 | E | 145 | 3x53 | G.H5 | H | 374 | G.H5.19 |
Polar | TM5 | R | 239 | 5x67 | G.H5 | Q | 371 | G.H5.16 |
Van-der-waals | TM5 | R | 239 | 5x67 | G.H5 | Q | 371 | G.H5.16 |
Ionic | C-term | E | 358 | - | G.H3 | R | 267 | G.H3.16 |
Polar | C-term | E | 358 | - | G.H3 | R | 267 | G.H3.16 |
Hydrophobic | C-term | E | 358 | - | G.H3 | R | 267 | G.H3.16 |
Van-der-waals | C-term | E | 358 | - | G.H3 | R | 267 | G.H3.16 |
Ionic | H8 | R | 318 | 8x49 | G.H5 | E | 379 | G.H5.24 |
Polar | H8 | R | 318 | 8x49 | G.H5 | E | 379 | G.H5.24 |
Hydrophobic | H8 | R | 318 | 8x49 | G.H5 | E | 379 | G.H5.24 |
Van-der-waals | H8 | R | 318 | 8x49 | G.H5 | E | 379 | G.H5.24 |
Polar | TM5 | L | 240 | 5x68 | G.H5 | R | 372 | G.H5.17 |
Hydrophobic | TM5 | L | 240 | 5x68 | G.H5 | R | 372 | G.H5.17 |
Van-der-waals | TM5 | L | 240 | 5x68 | G.H5 | R | 372 | G.H5.17 |
Hydrophobic | TM2 | V | 81 | 2x39 | G.H5 | Y | 378 | G.H5.23 |
Van-der-waals | TM2 | V | 81 | 2x39 | G.H5 | Y | 378 | G.H5.23 |
Polar | TM3 | V | 147 | 3x55 | G.H5 | R | 367 | G.H5.12 |
Hydrophobic | TM3 | I | 146 | 3x54 | G.H5 | H | 374 | G.H5.19 |
Polar | H8 | H | 317 | 8x48 | G.H5 | E | 379 | G.H5.24 |
Hydrophobic | H8 | H | 317 | 8x48 | G.H5 | E | 379 | G.H5.24 |
Van-der-waals | H8 | H | 317 | 8x48 | G.H5 | E | 379 | G.H5.24 |
Hydrophobic | TM6 | G | 244 | 6x29 | G.H5 | L | 381 | G.H5.26 |
Hydrophobic | ICL2 | R | 154 | 34x55 | G.hns1 | K | 40 | G.hns1.02 |
Van-der-waals | ICL2 | R | 154 | 34x55 | G.hns1 | K | 40 | G.hns1.02 |
Polar | TM6 | A | 248 | 6x33 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | TM6 | A | 248 | 6x33 | G.H5 | L | 380 | G.H5.25 |
Van-der-waals | TM6 | A | 248 | 6x33 | G.H5 | L | 380 | G.H5.25 |
Polar | ICL2 | H | 153 | 34x54 | G.h2s4 | V | 228 | G.h2s4.04 |
Hydrophobic | ICL2 | H | 153 | 34x54 | G.h2s4 | V | 228 | G.h2s4.04 |
Van-der-waals | ICL2 | H | 153 | 34x54 | G.h2s4 | V | 228 | G.h2s4.04 |
Hydrophobic | ICL2 | A | 149 | 34x50 | G.H5 | H | 374 | G.H5.19 |
Hydrophobic | TM5 | L | 240 | 5x68 | G.H5 | D | 368 | G.H5.13 |
Van-der-waals | TM5 | L | 240 | 5x68 | G.H5 | D | 368 | G.H5.13 |
Hydrophobic | ICL2 | P | 151 | 34x52 | G.S1 | T | 42 | G.S1.01 |
Van-der-waals | ICL2 | P | 151 | 34x52 | G.S1 | T | 42 | G.S1.01 |