GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 80.0
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 15.0
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Polar | ICL2 | Y | 152 | 34x53 | G.H5 | Q | 390 | G.H5.22 |
Hydrophobic | ICL2 | Y | 152 | 34x53 | G.H5 | Q | 390 | G.H5.22 |
Van-der-waals | ICL2 | Y | 152 | 34x53 | G.H5 | Q | 390 | G.H5.22 |
Hydrophobic | C-term | S | 351 | - | G.H3 | W | 281 | G.H3.17 |
Van-der-waals | C-term | S | 351 | - | G.H3 | W | 281 | G.H3.17 |
Hydrophobic | ICL2 | R | 154 | 34x55 | G.hns1 | A | 39 | G.hns1.03 |
Van-der-waals | ICL2 | R | 154 | 34x55 | G.hns1 | A | 39 | G.hns1.03 |
Hydrophobic | TM5 | R | 239 | 5x67 | G.H5 | R | 380 | G.H5.12 |
Van-der-waals | TM5 | R | 239 | 5x67 | G.H5 | R | 380 | G.H5.12 |
Hydrophobic | TM3 | I | 146 | 3x54 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | C-term | L | 365 | - | G.H3 | S | 275 | G.H3.11 |
Van-der-waals | C-term | L | 365 | - | G.H3 | S | 275 | G.H3.11 |
Hydrophobic | TM3 | I | 146 | 3x54 | G.H5 | L | 388 | G.H5.20 |
Polar | TM3 | K | 142 | 3x50 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | TM3 | K | 142 | 3x50 | G.H5 | Y | 391 | G.H5.23 |
Van-der-waals | TM3 | K | 142 | 3x50 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | ICL2 | P | 151 | 34x52 | G.H5 | I | 383 | G.H5.15 |
Polar | ICL2 | Y | 152 | 34x53 | G.H5 | H | 387 | G.H5.19 |
Aromatic | ICL2 | Y | 152 | 34x53 | G.H5 | H | 387 | G.H5.19 |
Hydrophobic | ICL2 | Y | 152 | 34x53 | G.H5 | H | 387 | G.H5.19 |
Van-der-waals | ICL2 | Y | 152 | 34x53 | G.H5 | H | 387 | G.H5.19 |
Ionic | C-term | E | 358 | - | G.H3 | R | 280 | G.H3.16 |
Polar | C-term | E | 358 | - | G.H3 | R | 280 | G.H3.16 |
Hydrophobic | C-term | E | 358 | - | G.H3 | R | 280 | G.H3.16 |
Van-der-waals | C-term | E | 358 | - | G.H3 | R | 280 | G.H3.16 |
Polar | C-term | A | 355 | - | G.H3 | R | 280 | G.H3.16 |
Hydrophobic | C-term | A | 355 | - | G.H3 | R | 280 | G.H3.16 |
Van-der-waals | C-term | A | 355 | - | G.H3 | R | 280 | G.H3.16 |
Polar | H8 | S | 316 | 8x47 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | H8 | S | 316 | 8x47 | G.H5 | E | 392 | G.H5.24 |
Van-der-waals | H8 | S | 316 | 8x47 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | C-term | M | 359 | - | G.H2 | I | 235 | G.H2.08 |
Van-der-waals | C-term | M | 359 | - | G.H2 | I | 235 | G.H2.08 |
Hydrophobic | TM3 | I | 146 | 3x54 | G.H5 | L | 393 | G.H5.25 |
Polar | TM3 | I | 146 | 3x54 | G.H5 | Q | 384 | G.H5.16 |
Hydrophobic | TM3 | I | 146 | 3x54 | G.H5 | Q | 384 | G.H5.16 |
Van-der-waals | TM3 | I | 146 | 3x54 | G.H5 | Q | 384 | G.H5.16 |
Hydrophobic | ICL2 | Y | 152 | 34x53 | G.H5 | M | 386 | G.H5.18 |
Polar | C-term | Q | 369 | - | G.H2 | R | 228 | G.H2.01 |
Polar | TM5 | R | 239 | 5x67 | G.H5 | Q | 384 | G.H5.16 |
Van-der-waals | TM5 | R | 239 | 5x67 | G.H5 | Q | 384 | G.H5.16 |
Hydrophobic | ICL2 | A | 149 | 34x50 | G.H5 | I | 383 | G.H5.15 |
Van-der-waals | ICL2 | A | 149 | 34x50 | G.H5 | I | 383 | G.H5.15 |
Polar | TM5 | L | 240 | 5x68 | G.H5 | R | 385 | G.H5.17 |
Hydrophobic | TM5 | L | 240 | 5x68 | G.H5 | R | 385 | G.H5.17 |
Van-der-waals | TM5 | L | 240 | 5x68 | G.H5 | R | 385 | G.H5.17 |
Van-der-waals | C-term | M | 362 | - | G.H3 | N | 279 | G.H3.15 |
Ionic | H8 | R | 318 | 8x49 | G.H5 | E | 392 | G.H5.24 |
Polar | H8 | R | 318 | 8x49 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | H8 | R | 318 | 8x49 | G.H5 | E | 392 | G.H5.24 |
Van-der-waals | H8 | R | 318 | 8x49 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | TM3 | I | 146 | 3x54 | G.H5 | H | 387 | G.H5.19 |
Polar | ICL2 | Q | 150 | 34x51 | G.H5 | H | 387 | G.H5.19 |
Van-der-waals | ICL2 | Q | 150 | 34x51 | G.H5 | H | 387 | G.H5.19 |
Hydrophobic | TM2 | V | 81 | 2x39 | G.H5 | Y | 391 | G.H5.23 |
Van-der-waals | TM2 | V | 81 | 2x39 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | ICL2 | A | 149 | 34x50 | G.H5 | Q | 384 | G.H5.16 |
Polar | ICL2 | L | 155 | 34x56 | G.hns1 | R | 38 | G.hns1.02 |
Hydrophobic | ICL2 | L | 155 | 34x56 | G.hns1 | R | 38 | G.hns1.02 |
Van-der-waals | ICL2 | L | 155 | 34x56 | G.hns1 | R | 38 | G.hns1.02 |
Hydrophobic | C-term | A | 355 | - | G.H3 | W | 281 | G.H3.17 |
Van-der-waals | C-term | A | 355 | - | G.H3 | W | 281 | G.H3.17 |
Hydrophobic | C-term | M | 362 | - | G.h2s4 | F | 238 | G.h2s4.01 |
Hydrophobic | ICL2 | P | 151 | 34x52 | G.S1 | H | 41 | G.S1.02 |
Van-der-waals | ICL2 | P | 151 | 34x52 | G.S1 | H | 41 | G.S1.02 |
Polar | TM4 | K | 160 | 4x41 | G.HN | Q | 35 | G.HN.52 |
Hydrophobic | TM4 | K | 160 | 4x41 | G.HN | Q | 35 | G.HN.52 |
Van-der-waals | TM4 | K | 160 | 4x41 | G.HN | Q | 35 | G.HN.52 |
Hydrophobic | TM5 | I | 233 | 5x61 | G.H5 | L | 393 | G.H5.25 |
Hydrophobic | ICL3 | P | 242 | - | G.H5 | L | 394 | G.H5.26 |
Van-der-waals | ICL3 | P | 242 | - | G.H5 | L | 394 | G.H5.26 |
Hydrophobic | TM5 | V | 236 | 5x64 | G.H5 | Q | 384 | G.H5.16 |
Van-der-waals | TM5 | V | 236 | 5x64 | G.H5 | Q | 384 | G.H5.16 |
Hydrophobic | TM5 | L | 240 | 5x68 | G.H5 | L | 388 | G.H5.20 |
Hydrophobic | TM6 | A | 248 | 6x33 | G.H5 | L | 393 | G.H5.25 |
Van-der-waals | TM6 | A | 248 | 6x33 | G.H5 | L | 393 | G.H5.25 |
Ionic | TM3 | E | 145 | 3x53 | G.H5 | H | 387 | G.H5.19 |
Polar | TM3 | E | 145 | 3x53 | G.H5 | H | 387 | G.H5.19 |
Hydrophobic | TM3 | E | 145 | 3x53 | G.H5 | H | 387 | G.H5.19 |
Van-der-waals | TM3 | E | 145 | 3x53 | G.H5 | H | 387 | G.H5.19 |
Polar | C-term | T | 354 | - | G.H3 | R | 280 | G.H3.16 |
Hydrophobic | C-term | T | 354 | - | G.H3 | R | 280 | G.H3.16 |
Van-der-waals | C-term | T | 354 | - | G.H3 | R | 280 | G.H3.16 |
Hydrophobic | C-term | M | 362 | - | G.H2 | W | 234 | G.H2.07 |
Polar | TM2 | R | 79 | 2x37 | G.H5 | Q | 390 | G.H5.22 |
Hydrophobic | TM2 | R | 79 | 2x37 | G.H5 | Q | 390 | G.H5.22 |
Van-der-waals | TM2 | R | 79 | 2x37 | G.H5 | Q | 390 | G.H5.22 |
Hydrophobic | ICL2 | P | 151 | 34x52 | G.hns1 | A | 39 | G.hns1.03 |
Polar | ICL2 | H | 153 | 34x54 | G.hns1 | R | 38 | G.hns1.02 |
Hydrophobic | ICL2 | H | 153 | 34x54 | G.hns1 | R | 38 | G.hns1.02 |
Van-der-waals | ICL2 | H | 153 | 34x54 | G.hns1 | R | 38 | G.hns1.02 |
Polar | H8 | H | 317 | 8x48 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | H8 | H | 317 | 8x48 | G.H5 | E | 392 | G.H5.24 |
Van-der-waals | H8 | H | 317 | 8x48 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | TM5 | L | 240 | 5x68 | G.H5 | Q | 384 | G.H5.16 |
Van-der-waals | TM5 | L | 240 | 5x68 | G.H5 | Q | 384 | G.H5.16 |
Hydrophobic | ICL2 | A | 149 | 34x50 | G.H5 | R | 380 | G.H5.12 |
Van-der-waals | ICL2 | A | 149 | 34x50 | G.H5 | R | 380 | G.H5.12 |
Ionic | ICL2 | H | 153 | 34x54 | G.h2s4 | D | 240 | G.h2s4.03 |
Hydrophobic | ICL2 | H | 153 | 34x54 | G.h2s4 | D | 240 | G.h2s4.03 |
Van-der-waals | ICL2 | H | 153 | 34x54 | G.h2s4 | D | 240 | G.h2s4.03 |
Polar | TM3 | V | 147 | 3x55 | G.H5 | Q | 384 | G.H5.16 |
Van-der-waals | TM3 | V | 147 | 3x55 | G.H5 | Q | 384 | G.H5.16 |
Polar | TM3 | E | 145 | 3x53 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | TM3 | E | 145 | 3x53 | G.H5 | Y | 391 | G.H5.23 |
Van-der-waals | TM3 | E | 145 | 3x53 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | ICL2 | P | 151 | 34x52 | G.hns1 | R | 38 | G.hns1.02 |
Van-der-waals | ICL2 | P | 151 | 34x52 | G.hns1 | R | 38 | G.hns1.02 |
Polar | ICL2 | R | 154 | 34x55 | G.hns1 | R | 38 | G.hns1.02 |
Hydrophobic | ICL2 | R | 154 | 34x55 | G.hns1 | R | 38 | G.hns1.02 |
Hydrophobic | ICL2 | Q | 150 | 34x51 | G.H5 | I | 383 | G.H5.15 |
Hydrophobic | TM5 | L | 237 | 5x65 | G.H5 | L | 388 | G.H5.20 |
Van-der-waals | TM5 | L | 237 | 5x65 | G.H5 | L | 388 | G.H5.20 |
Hydrophobic | TM6 | I | 251 | 6x36 | G.H5 | L | 393 | G.H5.25 |
Hydrophobic | TM5 | L | 240 | 5x68 | G.H5 | D | 381 | G.H5.13 |
Van-der-waals | TM5 | L | 240 | 5x68 | G.H5 | D | 381 | G.H5.13 |