GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 80.5
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.5
iPTM Score: 0.4
PAE mean: 23.1
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | TM6 | I | 254 | 6x37 | G.H5 | L | 358 | G.H5.25 |
Hydrophobic | TM5 | S | 242 | 5x68 | G.s2s3 | S | 198 | G.s2s3.02 |
Van-der-waals | TM5 | S | 242 | 5x68 | G.s2s3 | S | 198 | G.s2s3.02 |
Polar | H8 | N | 319 | 8x47 | G.H5 | N | 357 | G.H5.24 |
Hydrophobic | H8 | N | 319 | 8x47 | G.H5 | N | 357 | G.H5.24 |
Van-der-waals | H8 | N | 319 | 8x47 | G.H5 | N | 357 | G.H5.24 |
Polar | TM2 | T | 79 | 2x39 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | TM2 | T | 79 | 2x39 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | TM3 | I | 146 | 3x54 | G.H5 | L | 353 | G.H5.20 |
Polar | TM3 | S | 145 | 3x53 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | TM3 | S | 145 | 3x53 | G.H5 | Y | 356 | G.H5.23 |
Van-der-waals | TM3 | S | 145 | 3x53 | G.H5 | Y | 356 | G.H5.23 |
Polar | TM6 | E | 246 | 6x29 | G.H5 | Q | 350 | G.H5.17 |
Hydrophobic | TM6 | E | 246 | 6x29 | G.H5 | Q | 350 | G.H5.17 |
Van-der-waals | TM6 | E | 246 | 6x29 | G.H5 | Q | 350 | G.H5.17 |
Polar | ICL2 | S | 154 | - | G.h3s5 | N | 266 | G.h3s5.02 |
Polar | H8 | K | 328 | 8x56 | G.h4s6 | S | 320 | G.h4s6.11 |
Hydrophobic | H8 | K | 328 | 8x56 | G.h4s6 | S | 320 | G.h4s6.11 |
Van-der-waals | H8 | K | 328 | 8x56 | G.h4s6 | S | 320 | G.h4s6.11 |
Hydrophobic | TM5 | S | 242 | 5x68 | G.s2s3 | Q | 197 | G.s2s3.01 |
Van-der-waals | TM5 | S | 242 | 5x68 | G.s2s3 | Q | 197 | G.s2s3.01 |
Polar | TM6 | S | 250 | 6x33 | G.H5 | L | 358 | G.H5.25 |
Hydrophobic | TM6 | S | 250 | 6x33 | G.H5 | L | 358 | G.H5.25 |
Van-der-waals | TM6 | S | 250 | 6x33 | G.H5 | L | 358 | G.H5.25 |
Polar | ICL3 | S | 243 | - | G.s2s3 | Q | 197 | G.s2s3.01 |
Hydrophobic | ICL3 | S | 243 | - | G.s2s3 | Q | 197 | G.s2s3.01 |
Van-der-waals | ICL3 | S | 243 | - | G.s2s3 | Q | 197 | G.s2s3.01 |
Polar | TM3 | R | 142 | 3x50 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | TM3 | R | 142 | 3x50 | G.H5 | Y | 356 | G.H5.23 |
Van-der-waals | TM3 | R | 142 | 3x50 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | TM3 | I | 146 | 3x54 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | TM2 | I | 83 | 2x43 | G.H5 | N | 357 | G.H5.24 |
Van-der-waals | TM2 | I | 83 | 2x43 | G.H5 | N | 357 | G.H5.24 |
Polar | TM3 | T | 147 | 3x55 | G.hns1 | R | 37 | G.hns1.02 |
Hydrophobic | TM3 | T | 147 | 3x55 | G.hns1 | R | 37 | G.hns1.02 |
Van-der-waals | TM3 | T | 147 | 3x55 | G.hns1 | R | 37 | G.hns1.02 |
Ionic | ICL3 | D | 244 | - | G.H5 | K | 345 | G.H5.12 |
Polar | ICL3 | D | 244 | - | G.H5 | K | 345 | G.H5.12 |
Hydrophobic | ICL3 | D | 244 | - | G.H5 | K | 345 | G.H5.12 |
Van-der-waals | ICL3 | D | 244 | - | G.H5 | K | 345 | G.H5.12 |
Polar | ICL2 | K | 158 | - | G.h3s5 | N | 266 | G.h3s5.02 |
Polar | TM5 | A | 238 | 5x64 | G.hns1 | R | 38 | G.hns1.03 |
Van-der-waals | TM5 | A | 238 | 5x64 | G.hns1 | R | 38 | G.hns1.03 |
Ionic | H8 | K | 328 | 8x56 | G.h4s6 | D | 321 | G.h4s6.12 |
Polar | H8 | K | 328 | 8x56 | G.h4s6 | D | 321 | G.h4s6.12 |
Hydrophobic | H8 | K | 328 | 8x56 | G.h4s6 | D | 321 | G.h4s6.12 |
Van-der-waals | H8 | K | 328 | 8x56 | G.h4s6 | D | 321 | G.h4s6.12 |
Polar | ICL3 | S | 243 | - | G.S2 | L | 196 | G.S2.08 |
Polar | H8 | N | 319 | 8x47 | G.H5 | V | 359 | G.H5.26 |
Hydrophobic | H8 | N | 319 | 8x47 | G.H5 | V | 359 | G.H5.26 |
Van-der-waals | H8 | N | 319 | 8x47 | G.H5 | V | 359 | G.H5.26 |
Hydrophobic | TM6 | Y | 257 | 6x40 | G.H5 | L | 358 | G.H5.25 |
Polar | TM6 | Y | 257 | 6x40 | G.H5 | N | 357 | G.H5.24 |
Van-der-waals | TM6 | Y | 257 | 6x40 | G.H5 | N | 357 | G.H5.24 |
Polar | ICL3 | D | 244 | - | G.s2s3 | S | 198 | G.s2s3.02 |
Hydrophobic | ICL3 | D | 244 | - | G.s2s3 | S | 198 | G.s2s3.02 |
Van-der-waals | ICL3 | D | 244 | - | G.s2s3 | S | 198 | G.s2s3.02 |
Hydrophobic | ICL2 | N | 151 | - | G.hns1 | R | 37 | G.hns1.02 |
Polar | ICL2 | T | 150 | - | G.hns1 | R | 37 | G.hns1.02 |
Hydrophobic | ICL2 | T | 150 | - | G.hns1 | R | 37 | G.hns1.02 |
Van-der-waals | ICL2 | T | 150 | - | G.hns1 | R | 37 | G.hns1.02 |
Hydrophobic | H8 | R | 320 | 8x48 | G.H5 | K | 354 | G.H5.21 |
Polar | TM5 | A | 241 | 5x67 | G.hns1 | R | 38 | G.hns1.03 |
Hydrophobic | TM5 | A | 241 | 5x67 | G.hns1 | R | 38 | G.hns1.03 |
Van-der-waals | TM5 | A | 241 | 5x67 | G.hns1 | R | 38 | G.hns1.03 |
Polar | ICL1 | T | 75 | 12x50 | G.h4s6 | D | 321 | G.h4s6.12 |
Hydrophobic | ICL1 | T | 75 | 12x50 | G.h4s6 | D | 321 | G.h4s6.12 |
Van-der-waals | ICL1 | T | 75 | 12x50 | G.h4s6 | D | 321 | G.h4s6.12 |
Polar | TM3 | R | 142 | 3x50 | G.H5 | N | 357 | G.H5.24 |
Van-der-waals | TM3 | R | 142 | 3x50 | G.H5 | N | 357 | G.H5.24 |
Hydrophobic | TM3 | I | 146 | 3x54 | G.H5 | L | 358 | G.H5.25 |
Van-der-waals | TM3 | I | 146 | 3x54 | G.H5 | L | 358 | G.H5.25 |
Polar | H8 | N | 321 | 8x49 | G.H5 | K | 354 | G.H5.21 |
Hydrophobic | H8 | N | 321 | 8x49 | G.H5 | K | 354 | G.H5.21 |
Van-der-waals | H8 | N | 321 | 8x49 | G.H5 | K | 354 | G.H5.21 |
Hydrophobic | H8 | Y | 324 | 8x52 | G.h4s6 | I | 323 | G.h4s6.20 |
Van-der-waals | H8 | Y | 324 | 8x52 | G.h4s6 | I | 323 | G.h4s6.20 |
Polar | ICL1 | T | 74 | 12x49 | G.h4s6 | D | 321 | G.h4s6.12 |
Hydrophobic | ICL1 | T | 74 | 12x49 | G.h4s6 | D | 321 | G.h4s6.12 |
Van-der-waals | ICL1 | T | 74 | 12x49 | G.h4s6 | D | 321 | G.h4s6.12 |
Hydrophobic | TM6 | I | 253 | 6x36 | G.H5 | V | 359 | G.H5.26 |
Polar | TM2 | Y | 77 | 2x37 | G.H5 | L | 351 | G.H5.18 |
Hydrophobic | TM2 | Y | 77 | 2x37 | G.H5 | L | 351 | G.H5.18 |
Van-der-waals | TM2 | Y | 77 | 2x37 | G.H5 | L | 351 | G.H5.18 |
Polar | H8 | N | 319 | 8x47 | G.H5 | K | 354 | G.H5.21 |
Hydrophobic | H8 | N | 319 | 8x47 | G.H5 | K | 354 | G.H5.21 |
Van-der-waals | H8 | N | 319 | 8x47 | G.H5 | K | 354 | G.H5.21 |
Polar | H8 | R | 320 | 8x48 | G.H5 | V | 359 | G.H5.26 |
Van-der-waals | H8 | R | 320 | 8x48 | G.H5 | V | 359 | G.H5.26 |
Polar | TM3 | Y | 148 | 3x56 | G.hns1 | R | 37 | G.hns1.02 |
Hydrophobic | TM3 | Y | 148 | 3x56 | G.hns1 | R | 37 | G.hns1.02 |
Van-der-waals | TM3 | Y | 148 | 3x56 | G.hns1 | R | 37 | G.hns1.02 |
Polar | ICL2 | N | 151 | - | G.hns1 | A | 36 | G.hns1.01 |
Hydrophobic | ICL2 | N | 151 | - | G.hns1 | A | 36 | G.hns1.01 |
Van-der-waals | ICL2 | N | 151 | - | G.hns1 | A | 36 | G.hns1.01 |
Hydrophobic | TM5 | I | 239 | 5x65 | G.H5 | L | 358 | G.H5.25 |
Hydrophobic | TM2 | Y | 77 | 2x37 | G.H5 | E | 355 | G.H5.22 |
Van-der-waals | TM2 | Y | 77 | 2x37 | G.H5 | E | 355 | G.H5.22 |
Hydrophobic | H8 | F | 332 | 8x60 | G.h4s6 | S | 320 | G.h4s6.11 |
Van-der-waals | H8 | F | 332 | 8x60 | G.h4s6 | S | 320 | G.h4s6.11 |
Hydrophobic | TM5 | L | 235 | 5x61 | G.H5 | L | 358 | G.H5.25 |
Hydrophobic | TM3 | R | 142 | 3x50 | G.H5 | L | 358 | G.H5.25 |
Polar | TM3 | Y | 148 | 3x56 | G.HN | R | 34 | G.HN.52 |
Hydrophobic | TM3 | Y | 148 | 3x56 | G.HN | R | 34 | G.HN.52 |
Van-der-waals | TM3 | Y | 148 | 3x56 | G.HN | R | 34 | G.HN.52 |
Ionic | TM4 | R | 161 | 4x42 | G.H5 | E | 355 | G.H5.22 |
Polar | TM4 | R | 161 | 4x42 | G.H5 | E | 355 | G.H5.22 |
Van-der-waals | TM4 | R | 161 | 4x42 | G.H5 | E | 355 | G.H5.22 |
Polar | TM2 | T | 79 | 2x39 | G.H5 | E | 355 | G.H5.22 |
Hydrophobic | TM2 | T | 79 | 2x39 | G.H5 | E | 355 | G.H5.22 |
Van-der-waals | TM2 | T | 79 | 2x39 | G.H5 | E | 355 | G.H5.22 |
Polar | TM2 | T | 79 | 2x39 | G.H5 | N | 357 | G.H5.24 |
Van-der-waals | TM2 | T | 79 | 2x39 | G.H5 | N | 357 | G.H5.24 |
Polar | ICL3 | S | 243 | - | G.s2s3 | S | 198 | G.s2s3.02 |
Hydrophobic | TM2 | Y | 77 | 2x37 | G.H5 | K | 354 | G.H5.21 |
Hydrophobic | TM6 | I | 253 | 6x36 | G.H5 | L | 358 | G.H5.25 |
Polar | TM4 | R | 161 | 4x42 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | TM4 | R | 161 | 4x42 | G.H5 | Y | 356 | G.H5.23 |
Van-der-waals | TM4 | R | 161 | 4x42 | G.H5 | Y | 356 | G.H5.23 |