GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 76.5
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.5
iPTM Score: 0.3
PAE mean: 22.9
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | ICL2 | Q | 147 | - | G.hns1 | V | 45 | G.hns1.01 |
Hydrophobic | TM6 | I | 233 | 6x28 | G.H5 | L | 371 | G.H5.20 |
Hydrophobic | TM3 | V | 141 | 3x54 | G.H5 | M | 375 | G.H5.24 |
Ionic | C-term | E | 339 | - | G.H2 | K | 231 | G.H2.05 |
Polar | C-term | E | 339 | - | G.H2 | K | 231 | G.H2.05 |
Hydrophobic | C-term | E | 339 | - | G.H2 | K | 231 | G.H2.05 |
Van-der-waals | C-term | E | 339 | - | G.H2 | K | 231 | G.H2.05 |
Polar | ICL2 | V | 144 | - | G.hns1 | K | 46 | G.hns1.02 |
Hydrophobic | ICL2 | V | 144 | - | G.hns1 | K | 46 | G.hns1.02 |
Van-der-waals | ICL2 | V | 144 | - | G.hns1 | K | 46 | G.hns1.02 |
Polar | H8 | K | 316 | 8x56 | G.h3s5 | S | 282 | G.h3s5.01 |
Hydrophobic | H8 | K | 316 | 8x56 | G.h3s5 | S | 282 | G.h3s5.01 |
Van-der-waals | H8 | K | 316 | 8x56 | G.h3s5 | S | 282 | G.h3s5.01 |
Polar | H8 | S | 309 | 8x49 | G.h3s5 | N | 283 | G.h3s5.02 |
Hydrophobic | H8 | S | 309 | 8x49 | G.h3s5 | N | 283 | G.h3s5.02 |
Van-der-waals | H8 | S | 309 | 8x49 | G.h3s5 | N | 283 | G.h3s5.02 |
Hydrophobic | C-term | F | 336 | - | G.H3 | T | 274 | G.H3.11 |
Van-der-waals | C-term | F | 336 | - | G.H3 | T | 274 | G.H3.11 |
Hydrophobic | TM3 | V | 139 | 3x52 | G.hns1 | K | 46 | G.hns1.02 |
Van-der-waals | TM3 | V | 139 | 3x52 | G.hns1 | K | 46 | G.hns1.02 |
Hydrophobic | TM6 | V | 241 | 6x36 | G.H5 | L | 376 | G.H5.25 |
Polar | H8 | K | 316 | 8x56 | G.H3 | R | 279 | G.H3.16 |
Hydrophobic | H8 | K | 316 | 8x56 | G.H3 | R | 279 | G.H3.16 |
Van-der-waals | H8 | K | 316 | 8x56 | G.H3 | R | 279 | G.H3.16 |
Polar | ICL2 | V | 144 | - | G.HN | Y | 44 | G.HN.53 |
Hydrophobic | ICL2 | V | 144 | - | G.HN | Y | 44 | G.HN.53 |
Van-der-waals | ICL2 | V | 144 | - | G.HN | Y | 44 | G.HN.53 |
Hydrophobic | ICL2 | V | 144 | - | G.S3 | P | 217 | G.S3.02 |
Van-der-waals | ICL2 | V | 144 | - | G.S3 | P | 217 | G.S3.02 |
Hydrophobic | TM6 | I | 233 | 6x28 | G.H5 | H | 368 | G.H5.17 |
Van-der-waals | TM6 | I | 233 | 6x28 | G.H5 | H | 368 | G.H5.17 |
Polar | H8 | N | 312 | 8x52 | G.h3s5 | N | 283 | G.h3s5.02 |
Hydrophobic | H8 | N | 312 | 8x52 | G.h3s5 | N | 283 | G.h3s5.02 |
Van-der-waals | H8 | N | 312 | 8x52 | G.h3s5 | N | 283 | G.h3s5.02 |
Hydrophobic | TM6 | L | 242 | 6x37 | G.H5 | M | 375 | G.H5.24 |
Van-der-waals | TM6 | L | 242 | 6x37 | G.H5 | M | 375 | G.H5.24 |
Hydrophobic | TM6 | I | 233 | 6x28 | G.H5 | D | 364 | G.H5.13 |
Van-der-waals | TM6 | I | 233 | 6x28 | G.H5 | D | 364 | G.H5.13 |
Polar | ICL2 | V | 144 | - | G.HN | T | 43 | G.HN.52 |
Hydrophobic | ICL2 | V | 144 | - | G.HN | T | 43 | G.HN.52 |
Van-der-waals | ICL2 | V | 144 | - | G.HN | T | 43 | G.HN.52 |
Ionic | TM3 | D | 136 | 3x49 | G.hns1 | K | 46 | G.hns1.02 |
Polar | TM3 | D | 136 | 3x49 | G.hns1 | K | 46 | G.hns1.02 |
Hydrophobic | TM3 | D | 136 | 3x49 | G.hns1 | K | 46 | G.hns1.02 |
Van-der-waals | TM3 | D | 136 | 3x49 | G.hns1 | K | 46 | G.hns1.02 |
Polar | ICL2 | P | 145 | - | G.HN | K | 42 | G.HN.51 |
Hydrophobic | ICL2 | P | 145 | - | G.HN | K | 42 | G.HN.51 |
Hydrophobic | TM5 | L | 227 | 5x65 | G.H5 | L | 371 | G.H5.20 |
Van-der-waals | TM5 | L | 227 | 5x65 | G.H5 | L | 371 | G.H5.20 |
Polar | TM3 | T | 142 | 3x55 | G.hns1 | R | 47 | G.hns1.03 |
Hydrophobic | TM3 | T | 142 | 3x55 | G.hns1 | R | 47 | G.hns1.03 |
Van-der-waals | TM3 | T | 142 | 3x55 | G.hns1 | R | 47 | G.hns1.03 |
Hydrophobic | ICL2 | V | 144 | - | G.hns1 | R | 47 | G.hns1.03 |
Van-der-waals | ICL2 | V | 144 | - | G.hns1 | R | 47 | G.hns1.03 |
Hydrophobic | TM3 | A | 140 | 3x53 | G.H5 | L | 374 | G.H5.23 |
Polar | H8 | S | 309 | 8x49 | G.H5 | L | 376 | G.H5.25 |
Van-der-waals | H8 | S | 309 | 8x49 | G.H5 | L | 376 | G.H5.25 |
Polar | TM3 | R | 137 | 3x50 | G.H5 | Q | 377 | G.H5.26 |
Van-der-waals | TM3 | R | 137 | 3x50 | G.H5 | Q | 377 | G.H5.26 |
Hydrophobic | TM6 | P | 238 | 6x33 | G.H5 | H | 368 | G.H5.17 |
Polar | ICL3 | N | 232 | - | G.H5 | D | 364 | G.H5.13 |
Hydrophobic | ICL3 | N | 232 | - | G.H5 | D | 364 | G.H5.13 |
Van-der-waals | ICL3 | N | 232 | - | G.H5 | D | 364 | G.H5.13 |
Polar | TM3 | K | 143 | 3x56 | G.hns1 | R | 47 | G.hns1.03 |
Hydrophobic | TM3 | K | 143 | 3x56 | G.hns1 | R | 47 | G.hns1.03 |
Van-der-waals | TM3 | K | 143 | 3x56 | G.hns1 | R | 47 | G.hns1.03 |
Hydrophobic | C-term | I | 350 | - | H.HB | M | 123 | H.HB.10 |
Hydrophobic | C-term | I | 350 | - | H.HA | R | 97 | H.HA.20 |
Van-der-waals | C-term | I | 350 | - | H.HA | R | 97 | H.HA.20 |
Ionic | H8 | K | 319 | 8x59 | G.h4s6 | D | 336 | G.h4s6.10 |
Polar | H8 | K | 319 | 8x59 | G.h4s6 | D | 336 | G.h4s6.10 |
Van-der-waals | H8 | K | 319 | 8x59 | G.h4s6 | D | 336 | G.h4s6.10 |
Polar | TM6 | K | 234 | 6x29 | G.H5 | H | 368 | G.H5.17 |
Hydrophobic | TM6 | K | 234 | 6x29 | G.H5 | H | 368 | G.H5.17 |
Van-der-waals | TM6 | K | 234 | 6x29 | G.H5 | H | 368 | G.H5.17 |
Hydrophobic | ICL2 | S | 148 | - | G.HN | K | 42 | G.HN.51 |
Ionic | C-term | E | 332 | - | G.h4s6 | R | 335 | G.h4s6.09 |
Polar | C-term | E | 332 | - | G.h4s6 | R | 335 | G.h4s6.09 |
Van-der-waals | C-term | E | 332 | - | G.h4s6 | R | 335 | G.h4s6.09 |
Hydrophobic | ICL2 | P | 145 | - | G.H5 | L | 374 | G.H5.23 |
Van-der-waals | ICL2 | P | 145 | - | G.H5 | L | 374 | G.H5.23 |
Hydrophobic | ICL2 | V | 144 | - | G.HN | K | 42 | G.HN.51 |
Van-der-waals | ICL2 | V | 144 | - | G.HN | K | 42 | G.HN.51 |
Hydrophobic | TM5 | T | 223 | 5x61 | G.H5 | M | 375 | G.H5.24 |
Polar | ICL2 | Q | 147 | - | G.h2s4 | S | 239 | G.h2s4.03 |
Hydrophobic | ICL2 | Q | 147 | - | G.h2s4 | S | 239 | G.h2s4.03 |
Van-der-waals | ICL2 | Q | 147 | - | G.h2s4 | S | 239 | G.h2s4.03 |
Polar | TM3 | R | 137 | 3x50 | G.H5 | M | 375 | G.H5.24 |
Hydrophobic | TM3 | R | 137 | 3x50 | G.H5 | M | 375 | G.H5.24 |
Van-der-waals | TM3 | R | 137 | 3x50 | G.H5 | M | 375 | G.H5.24 |
Polar | ICL2 | S | 146 | - | G.HN | E | 41 | G.HN.50 |
Hydrophobic | C-term | F | 334 | - | G.h4s6 | R | 335 | G.h4s6.09 |
Van-der-waals | C-term | F | 334 | - | G.h4s6 | R | 335 | G.h4s6.09 |
Hydrophobic | TM5 | M | 230 | 5x68 | G.H5 | L | 371 | G.H5.20 |
Van-der-waals | TM5 | M | 230 | 5x68 | G.H5 | L | 371 | G.H5.20 |
Hydrophobic | TM2 | I | 80 | 2x43 | G.H5 | Q | 377 | G.H5.26 |
Hydrophobic | TM3 | A | 140 | 3x53 | G.hns1 | K | 46 | G.hns1.02 |
Hydrophobic | C-term | I | 350 | - | H.HA | D | 101 | H.HA.24 |
Van-der-waals | C-term | I | 350 | - | H.HA | D | 101 | H.HA.24 |
Hydrophobic | TM6 | P | 238 | 6x33 | G.H5 | M | 375 | G.H5.24 |
Van-der-waals | TM6 | P | 238 | 6x33 | G.H5 | M | 375 | G.H5.24 |
Hydrophobic | TM3 | V | 141 | 3x54 | G.H5 | L | 371 | G.H5.20 |
Ionic | C-term | D | 337 | - | G.H2 | K | 231 | G.H2.05 |
Polar | C-term | D | 337 | - | G.H2 | K | 231 | G.H2.05 |
Van-der-waals | C-term | D | 337 | - | G.H2 | K | 231 | G.H2.05 |
Hydrophobic | ICL2 | P | 145 | - | G.hns1 | R | 47 | G.hns1.03 |
Van-der-waals | ICL2 | P | 145 | - | G.hns1 | R | 47 | G.hns1.03 |
Hydrophobic | TM7 | M | 306 | 7x56 | G.H5 | L | 376 | G.H5.25 |
Van-der-waals | TM7 | M | 306 | 7x56 | G.H5 | L | 376 | G.H5.25 |
Polar | ICL1 | Q | 72 | 12x50 | G.h2s4 | D | 238 | G.h2s4.02 |
Hydrophobic | ICL1 | Q | 72 | 12x50 | G.h2s4 | D | 238 | G.h2s4.02 |
Van-der-waals | ICL1 | Q | 72 | 12x50 | G.h2s4 | D | 238 | G.h2s4.02 |
Hydrophobic | TM6 | P | 238 | 6x33 | G.H5 | K | 372 | G.H5.21 |
Polar | ICL2 | V | 144 | - | G.hns1 | V | 45 | G.hns1.01 |
Hydrophobic | ICL2 | V | 144 | - | G.hns1 | V | 45 | G.hns1.01 |
Van-der-waals | ICL2 | V | 144 | - | G.hns1 | V | 45 | G.hns1.01 |
Hydrophobic | TM6 | I | 233 | 6x28 | G.H5 | L | 367 | G.H5.16 |
Van-der-waals | TM6 | I | 233 | 6x28 | G.H5 | L | 367 | G.H5.16 |
Hydrophobic | C-term | F | 334 | - | G.H3 | T | 274 | G.H3.11 |
Polar | TM3 | K | 143 | 3x56 | G.HN | T | 43 | G.HN.52 |
Hydrophobic | TM3 | K | 143 | 3x56 | G.HN | T | 43 | G.HN.52 |
Van-der-waals | TM3 | K | 143 | 3x56 | G.HN | T | 43 | G.HN.52 |
Hydrophobic | ICL2 | S | 146 | - | G.hns1 | V | 45 | G.hns1.01 |
Polar | H8 | N | 312 | 8x52 | G.h3s5 | S | 282 | G.h3s5.01 |
Van-der-waals | H8 | N | 312 | 8x52 | G.h3s5 | S | 282 | G.h3s5.01 |
Hydrophobic | TM2 | T | 76 | 2x39 | G.H5 | Q | 377 | G.H5.26 |
Van-der-waals | TM2 | T | 76 | 2x39 | G.H5 | Q | 377 | G.H5.26 |
Hydrophobic | TM2 | T | 74 | 2x37 | G.H5 | Q | 377 | G.H5.26 |
Hydrophobic | C-term | F | 348 | - | H.HA | K | 105 | H.HA.28 |
Van-der-waals | C-term | F | 348 | - | H.HA | K | 105 | H.HA.28 |
Hydrophobic | TM3 | A | 140 | 3x53 | G.hns1 | R | 47 | G.hns1.03 |
Van-der-waals | TM3 | A | 140 | 3x53 | G.hns1 | R | 47 | G.hns1.03 |
Polar | ICL2 | P | 145 | - | G.hns1 | K | 46 | G.hns1.02 |
Hydrophobic | ICL2 | P | 145 | - | G.hns1 | K | 46 | G.hns1.02 |
Van-der-waals | ICL2 | P | 145 | - | G.hns1 | K | 46 | G.hns1.02 |
Hydrophobic | C-term | F | 348 | - | G.s4h3 | R | 260 | G.s4h3.12 |
Van-der-waals | C-term | F | 348 | - | G.s4h3 | R | 260 | G.s4h3.12 |
Hydrophobic | H8 | M | 315 | 8x55 | G.h4s6 | Q | 339 | G.h4s6.13 |
Van-der-waals | H8 | M | 315 | 8x55 | G.h4s6 | Q | 339 | G.h4s6.13 |
Polar | ICL2 | S | 146 | - | G.HN | K | 42 | G.HN.51 |
Hydrophobic | ICL2 | S | 146 | - | G.HN | K | 42 | G.HN.51 |
Van-der-waals | ICL2 | S | 146 | - | G.HN | K | 42 | G.HN.51 |
Hydrophobic | C-term | F | 336 | - | G.H3 | I | 275 | G.H3.12 |
Hydrophobic | TM5 | M | 230 | 5x68 | G.S3 | V | 216 | G.S3.01 |
Hydrophobic | ICL2 | V | 144 | - | G.S1 | L | 48 | G.S1.01 |
Van-der-waals | ICL2 | V | 144 | - | G.S1 | L | 48 | G.S1.01 |
Hydrophobic | TM5 | L | 227 | 5x65 | G.H5 | M | 375 | G.H5.24 |
Hydrophobic | H8 | G | 307 | 8x47 | G.H5 | L | 376 | G.H5.25 |
Van-der-waals | H8 | G | 307 | 8x47 | G.H5 | L | 376 | G.H5.25 |
Polar | TM3 | V | 141 | 3x54 | G.hns1 | R | 47 | G.hns1.03 |
Hydrophobic | TM3 | V | 141 | 3x54 | G.hns1 | R | 47 | G.hns1.03 |
Van-der-waals | TM3 | V | 141 | 3x54 | G.hns1 | R | 47 | G.hns1.03 |
Polar | H8 | A | 308 | 8x48 | G.H5 | L | 376 | G.H5.25 |
Hydrophobic | H8 | A | 308 | 8x48 | G.H5 | L | 376 | G.H5.25 |
Van-der-waals | H8 | A | 308 | 8x48 | G.H5 | L | 376 | G.H5.25 |
Hydrophobic | ICL2 | P | 145 | - | G.hns1 | V | 45 | G.hns1.01 |
Van-der-waals | ICL2 | P | 145 | - | G.hns1 | V | 45 | G.hns1.01 |