Ggust - ACKR4 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 82.4

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 12.4


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM3 A 140 3x53 G.H5 C 351 G.H5.23
Van-der-waals TM3 A 140 3x53 G.H5 C 351 G.H5.23
Polar TM3 T 142 3x55 G.hns1 R 32 G.hns1.03
Hydrophobic TM3 T 142 3x55 G.hns1 R 32 G.hns1.03
Van-der-waals TM3 T 142 3x55 G.hns1 R 32 G.hns1.03
Hydrophobic TM3 V 141 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 V 141 3x54 G.H5 L 348 G.H5.20
Hydrophobic TM5 T 223 5x61 G.H5 L 353 G.H5.25
Polar TM3 R 137 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 137 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 137 3x50 G.H5 C 351 G.H5.23
Ionic TM3 K 143 3x56 G.HN E 28 G.HN.52
Ionic C-term E 339 - G.H2 K 209 G.H2.05
Ionic H8 K 316 8x56 G.h4s6 D 316 G.h4s6.10
Polar H8 K 316 8x56 G.h4s6 D 316 G.h4s6.10
Van-der-waals H8 K 316 8x56 G.h4s6 D 316 G.h4s6.10
Hydrophobic TM3 K 143 3x56 G.hns1 A 31 G.hns1.02
Hydrophobic H8 S 309 8x49 G.H5 K 349 G.H5.21
Aromatic C-term F 336 - G.H3 H 256 G.H3.15
Hydrophobic C-term F 336 - G.H3 H 256 G.H3.15
Van-der-waals C-term F 336 - G.H3 H 256 G.H3.15
Polar ICL2 V 144 - G.hns1 A 31 G.hns1.02
Hydrophobic ICL2 V 144 - G.hns1 A 31 G.hns1.02
Van-der-waals ICL2 V 144 - G.hns1 A 31 G.hns1.02
Aromatic TM6 R 237 6x32 G.H5 F 354 G.H5.26
Hydrophobic TM6 R 237 6x32 G.H5 F 354 G.H5.26
Van-der-waals TM6 R 237 6x32 G.H5 F 354 G.H5.26
Hydrophobic ICL2 V 144 - G.S1 V 34 G.S1.02
Van-der-waals ICL2 V 144 - G.S1 V 34 G.S1.02
Polar ICL3 N 232 - G.H5 D 337 G.H5.09
Hydrophobic TM3 V 141 3x54 G.H5 L 353 G.H5.25
Hydrophobic TM5 M 230 5x68 G.H5 I 344 G.H5.16
Hydrophobic C-term F 336 - G.h2s4 F 215 G.h2s4.01
Hydrophobic TM6 P 238 6x33 G.H5 L 348 G.H5.20
Hydrophobic ICL2 V 144 - G.S1 T 33 G.S1.01
Van-der-waals ICL2 V 144 - G.S1 T 33 G.S1.01
Polar ICL2 Q 147 - G.h2s4 T 219 G.h2s4.05
Hydrophobic TM6 I 233 6x28 G.H5 D 341 G.H5.13
Polar ICL1 Q 72 12x50 G.h3s5 S 260 G.h3s5.01
Van-der-waals ICL1 Q 72 12x50 G.h3s5 S 260 G.h3s5.01
Polar ICL1 Q 72 12x50 G.h3s5 T 261 G.h3s5.02
Hydrophobic ICL1 Q 72 12x50 G.h3s5 T 261 G.h3s5.02
Van-der-waals ICL1 Q 72 12x50 G.h3s5 T 261 G.h3s5.02
Hydrophobic TM6 V 241 6x36 G.H5 L 353 G.H5.25
Hydrophobic ICL2 V 144 - G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 V 144 - G.hns1 R 32 G.hns1.03
Hydrophobic C-term F 334 - G.H3 N 251 G.H3.10
Van-der-waals TM7 M 306 7x56 G.H5 G 352 G.H5.24
Polar TM2 T 76 2x39 G.H5 C 351 G.H5.23
Hydrophobic TM2 T 76 2x39 G.H5 C 351 G.H5.23
Polar ICL2 Q 147 - G.h3s5 T 261 G.h3s5.02
Hydrophobic ICL2 Q 147 - G.h3s5 T 261 G.h3s5.02
Van-der-waals ICL2 Q 147 - G.h3s5 T 261 G.h3s5.02
Polar H8 A 308 8x48 G.H5 F 354 G.H5.26
Hydrophobic H8 A 308 8x48 G.H5 F 354 G.H5.26
Van-der-waals H8 A 308 8x48 G.H5 F 354 G.H5.26
Polar TM3 A 140 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 A 140 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 A 140 3x53 G.H5 N 347 G.H5.19
Polar H8 Y 313 8x53 G.h4s6 D 316 G.h4s6.10
Hydrophobic H8 Y 313 8x53 G.h4s6 D 316 G.h4s6.10
Hydrophobic TM6 I 233 6x28 G.H5 I 344 G.H5.16
Van-der-waals TM6 I 233 6x28 G.H5 I 344 G.H5.16
Hydrophobic ICL2 P 145 - G.S1 V 34 G.S1.02
Polar TM2 T 74 2x37 G.H5 D 350 G.H5.22
Hydrophobic TM2 T 74 2x37 G.H5 D 350 G.H5.22
Van-der-waals TM2 T 74 2x37 G.H5 D 350 G.H5.22
Hydrophobic C-term F 336 - G.H3 S 252 G.H3.11
Van-der-waals C-term F 336 - G.H3 S 252 G.H3.11
Hydrophobic ICL2 V 144 - G.S3 L 194 G.S3.01
Van-der-waals ICL2 V 144 - G.S3 L 194 G.S3.01
Hydrophobic ICL2 P 145 - G.H5 N 347 G.H5.19
Van-der-waals ICL2 P 145 - G.H5 N 347 G.H5.19
Polar ICL2 P 145 - G.h2s4 T 219 G.h2s4.05
Hydrophobic ICL2 P 145 - G.h2s4 T 219 G.h2s4.05
Hydrophobic ICL2 P 145 - G.H5 I 343 G.H5.15
Hydrophobic H8 G 307 8x47 G.H5 F 354 G.H5.26
Van-der-waals H8 G 307 8x47 G.H5 F 354 G.H5.26
Hydrophobic TM6 P 238 6x33 G.H5 F 354 G.H5.26
Hydrophobic ICL3 N 232 - G.H5 D 341 G.H5.13
Hydrophobic TM3 K 143 3x56 G.hns1 R 32 G.hns1.03
Polar TM6 P 238 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM6 P 238 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 P 238 6x33 G.H5 L 353 G.H5.25
Polar TM3 R 137 3x50 G.H5 G 352 G.H5.24
Hydrophobic TM3 R 137 3x50 G.H5 G 352 G.H5.24
Van-der-waals TM3 R 137 3x50 G.H5 G 352 G.H5.24
Hydrophobic TM6 L 242 6x37 G.H5 L 353 G.H5.25
Hydrophobic TM5 L 227 5x65 G.H5 L 348 G.H5.20
Polar TM7 M 306 7x56 G.H5 F 354 G.H5.26
Hydrophobic TM7 M 306 7x56 G.H5 F 354 G.H5.26
Van-der-waals TM7 M 306 7x56 G.H5 F 354 G.H5.26
Ionic H8 K 316 8x56 G.h4s6 E 315 G.h4s6.09
Polar H8 K 316 8x56 G.h4s6 E 315 G.h4s6.09
Hydrophobic H8 K 316 8x56 G.h4s6 E 315 G.h4s6.09
Van-der-waals H8 K 316 8x56 G.h4s6 E 315 G.h4s6.09
Hydrophobic C-term V 331 - G.h4s6 L 312 G.h4s6.03
Van-der-waals C-term V 331 - G.h4s6 L 312 G.h4s6.03
Polar ICL2 Q 147 - G.h3s5 T 262 G.h3s5.03
Hydrophobic ICL2 Q 147 - G.h3s5 T 262 G.h3s5.03
Van-der-waals ICL2 Q 147 - G.h3s5 T 262 G.h3s5.03
Hydrophobic C-term F 336 - G.H3 I 253 G.H3.12
Van-der-waals C-term F 336 - G.H3 I 253 G.H3.12
Hydrophobic TM3 R 137 3x50 G.H5 L 353 G.H5.25