G12 - M1 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 86.9

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.8
PAE mean: 12.8


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM7 A 419 7x54 G.H5 M 379 G.H5.24
Hydrophobic TM6 L 367 6x37 G.H5 L 380 G.H5.25
Hydrophobic H8 N 422 8x47 G.H5 M 379 G.H5.24
Van-der-waals H8 N 422 8x47 G.H5 M 379 G.H5.24
Polar TM3 R 123 3x50 G.H5 I 378 G.H5.23
Hydrophobic TM3 R 123 3x50 G.H5 I 378 G.H5.23
Van-der-waals TM3 R 123 3x50 G.H5 I 378 G.H5.23
Polar TM5 L 225 5x75 G.S6 H 348 G.S6.03
Van-der-waals TM5 L 225 5x75 G.S6 H 348 G.S6.03
Hydrophobic TM6 K 362 6x32 G.H5 Q 381 G.H5.26
Van-der-waals TM6 K 362 6x32 G.H5 Q 381 G.H5.26
Polar TM5 R 218 5x68 G.H5 K 367 G.H5.12
Hydrophobic TM5 R 218 5x68 G.H5 K 367 G.H5.12
Van-der-waals TM5 R 218 5x68 G.H5 K 367 G.H5.12
Hydrophobic ICL2 R 134 34x54 G.H5 I 370 G.H5.15
Hydrophobic ICL2 L 131 34x51 G.H5 F 363 G.H5.08
Hydrophobic ICL2 A 135 34x55 G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 A 135 34x55 G.hns1 R 56 G.hns1.03
Hydrophobic TM5 L 225 5x75 G.S6 F 347 G.S6.02
Van-der-waals TM5 L 225 5x75 G.S6 F 347 G.S6.02
Hydrophobic TM7 C 421 7x56 G.H5 M 379 G.H5.24
Van-der-waals TM7 C 421 7x56 G.H5 M 379 G.H5.24
Hydrophobic ICL2 P 130 34x50 G.H5 K 367 G.H5.12
Hydrophobic ICL2 L 131 34x51 G.S1 V 58 G.S1.02
Van-der-waals ICL2 L 131 34x51 G.S1 V 58 G.S1.02
Ionic ICL2 R 134 34x54 G.H5 E 373 G.H5.18
Polar ICL2 R 134 34x54 G.H5 E 373 G.H5.18
Van-der-waals ICL2 R 134 34x54 G.H5 E 373 G.H5.18
Hydrophobic TM5 L 225 5x75 G.H5 F 361 G.H5.06
Van-der-waals TM5 L 225 5x75 G.H5 F 361 G.H5.06
Hydrophobic C-term P 449 - G.H3 K 284 G.H3.16
Van-der-waals C-term P 449 - G.H3 K 284 G.H3.16
Hydrophobic ICL2 P 130 34x50 G.H5 L 371 G.H5.16
Hydrophobic TM5 I 211 5x61 G.H5 L 380 G.H5.25
Hydrophobic TM3 S 126 3x53 G.H5 I 378 G.H5.23
Hydrophobic TM5 R 218 5x68 G.H5 L 371 G.H5.16
Van-der-waals TM5 R 218 5x68 G.H5 L 371 G.H5.16
Hydrophobic ICL2 P 130 34x50 G.H5 I 370 G.H5.15
Polar TM2 N 60 2x39 G.H5 D 377 G.H5.22
Hydrophobic C-term P 449 - G.h3s5 F 287 G.h3s5.01
Hydrophobic ICL2 L 131 34x51 G.H5 I 370 G.H5.15
Van-der-waals ICL2 L 131 34x51 G.H5 I 370 G.H5.15
Hydrophobic ICL3 G 227 - G.S6 H 348 G.S6.03
Hydrophobic ICL3 Q 226 - G.h4s6 P 345 G.h4s6.20
Van-der-waals ICL3 Q 226 - G.h4s6 P 345 G.h4s6.20
Ionic C-term R 448 - G.h2s4 D 243 G.h2s4.02
Polar C-term R 448 - G.h2s4 D 243 G.h2s4.02
Van-der-waals C-term R 448 - G.h2s4 D 243 G.h2s4.02
Hydrophobic C-term G 450 - G.H3 L 285 G.H3.17
Hydrophobic TM3 V 127 3x54 G.H5 L 375 G.H5.20
Ionic TM5 E 214 5x64 G.H5 K 367 G.H5.12
Hydrophobic TM5 L 225 5x75 G.H5 A 365 G.H5.10
Hydrophobic TM2 L 64 2x43 G.H5 M 379 G.H5.24
Van-der-waals TM2 L 64 2x43 G.H5 M 379 G.H5.24
Hydrophobic TM3 V 127 3x54 G.H5 L 371 G.H5.16
Van-der-waals TM3 V 127 3x54 G.H5 L 371 G.H5.16
Hydrophobic ICL2 L 131 34x51 G.H5 V 366 G.H5.11
Hydrophobic TM7 Y 418 7x53 G.H5 M 379 G.H5.24
Van-der-waals TM7 Y 418 7x53 G.H5 M 379 G.H5.24
Polar ICL3 Q 226 - G.S6 H 348 G.S6.03
Hydrophobic ICL3 Q 226 - G.S6 H 348 G.S6.03
Van-der-waals ICL3 Q 226 - G.S6 H 348 G.S6.03
Van-der-waals TM2 N 60 2x39 G.H5 I 378 G.H5.23
Hydrophobic TM5 L 225 5x75 G.H5 D 368 G.H5.13
Hydrophobic ICL2 L 131 34x51 G.H5 K 367 G.H5.12
Polar ICL2 P 130 34x50 G.H5 N 374 G.H5.19
Van-der-waals ICL2 P 130 34x50 G.H5 N 374 G.H5.19
Ionic TM5 R 218 5x68 G.H5 D 368 G.H5.13
Polar TM5 R 218 5x68 G.H5 D 368 G.H5.13
Van-der-waals TM5 R 218 5x68 G.H5 D 368 G.H5.13
Hydrophobic ICL2 A 135 34x55 G.hns1 R 55 G.hns1.02
Van-der-waals ICL2 A 135 34x55 G.hns1 R 55 G.hns1.02
Hydrophobic TM5 L 225 5x75 G.H5 H 364 G.H5.09
Polar C-term S 451 - G.H3 K 284 G.H3.16
Hydrophobic TM5 L 222 5x72 G.S6 F 347 G.S6.02
Van-der-waals TM5 L 222 5x72 G.S6 F 347 G.S6.02
Hydrophobic ICL3 Q 226 - G.S6 F 347 G.S6.02
Polar TM3 S 126 3x53 G.H5 N 374 G.H5.19
Hydrophobic TM3 S 126 3x53 G.H5 N 374 G.H5.19
Van-der-waals TM3 S 126 3x53 G.H5 N 374 G.H5.19
Hydrophobic TM3 V 127 3x54 G.H5 I 378 G.H5.23
Van-der-waals TM3 V 127 3x54 G.H5 I 378 G.H5.23
Polar TM6 K 359 6x29 G.H5 Q 381 G.H5.26
Hydrophobic TM6 K 359 6x29 G.H5 Q 381 G.H5.26
Hydrophobic ICL2 L 131 34x51 G.S3 I 221 G.S3.01
Van-der-waals ICL2 L 131 34x51 G.S3 I 221 G.S3.01
Ionic ICL3 R 352 - G.H4 D 336 G.H4.16
Polar ICL3 R 352 - G.H4 D 336 G.H4.16
Hydrophobic ICL3 R 352 - G.H4 D 336 G.H4.16
Van-der-waals ICL3 R 352 - G.H4 D 336 G.H4.16
Hydrophobic TM5 L 222 5x72 G.H5 D 368 G.H5.13
Van-der-waals TM5 L 222 5x72 G.H5 D 368 G.H5.13
Polar TM6 K 359 6x29 G.H5 Q 372 G.H5.17
Hydrophobic TM6 T 366 6x36 G.H5 L 380 G.H5.25
Hydrophobic TM5 L 222 5x72 G.h4s6 P 345 G.h4s6.20
Ionic TM5 E 221 5x71 G.H5 K 367 G.H5.12