Gz - M1 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 89.5

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.8
PAE mean: 11.3


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM3 V 127 3x54 G.H5 L 349 G.H5.20
Van-der-waals TM3 V 127 3x54 G.H5 L 349 G.H5.20
Polar H8 N 422 8x47 G.H5 Y 351 G.H5.22
Hydrophobic H8 N 422 8x47 G.H5 Y 351 G.H5.22
Van-der-waals H8 N 422 8x47 G.H5 Y 351 G.H5.22
Hydrophobic ICL2 L 131 34x51 G.H5 T 341 G.H5.12
Van-der-waals ICL2 L 131 34x51 G.H5 T 341 G.H5.12
Hydrophobic TM5 L 225 5x75 G.H5 D 342 G.H5.13
Hydrophobic TM6 T 366 6x36 G.H5 L 354 G.H5.25
Hydrophobic TM6 L 367 6x37 G.H5 L 354 G.H5.25
Hydrophobic TM4 P 139 4x39 G.hns1 R 31 G.hns1.02
Polar TM6 A 363 6x33 G.H5 L 354 G.H5.25
Hydrophobic TM6 A 363 6x33 G.H5 L 354 G.H5.25
Hydrophobic TM3 V 127 3x54 G.H5 I 352 G.H5.23
Polar TM6 K 362 6x32 G.H5 C 355 G.H5.26
Hydrophobic TM6 K 362 6x32 G.H5 C 355 G.H5.26
Van-der-waals TM6 K 362 6x32 G.H5 C 355 G.H5.26
Hydrophobic TM5 R 218 5x68 G.H5 I 345 G.H5.16
Van-der-waals TM5 R 218 5x68 G.H5 I 345 G.H5.16
Hydrophobic TM5 I 211 5x61 G.H5 L 354 G.H5.25
Polar ICL3 Q 348 - G.H4 R 306 G.H4.13
Hydrophobic ICL3 Q 348 - G.H4 R 306 G.H4.13
Van-der-waals ICL3 Q 348 - G.H4 R 306 G.H4.13
Polar TM5 L 225 5x75 G.S6 S 322 G.S6.03
Van-der-waals TM5 L 225 5x75 G.S6 S 322 G.S6.03
Hydrophobic TM6 F 355 6x25 G.h4s6 E 316 G.h4s6.09
Hydrophobic ICL2 P 130 34x50 G.H5 I 345 G.H5.16
Van-der-waals ICL2 P 130 34x50 G.H5 I 345 G.H5.16
Hydrophobic TM7 C 421 7x56 G.H5 I 352 G.H5.23
Van-der-waals TM7 C 421 7x56 G.H5 I 352 G.H5.23
Hydrophobic TM5 L 222 5x72 G.H5 D 342 G.H5.13
Polar ICL3 Q 226 - G.H4 Q 305 G.H4.12
Van-der-waals ICL3 Q 226 - G.H4 Q 305 G.H4.12
Polar ICL3 Q 348 - G.H4 D 310 G.H4.17
Van-der-waals C-term R 458 - G.H3 R 249 G.H3.07
Polar ICL3 G 227 - G.S6 S 322 G.S6.03
Hydrophobic TM5 L 225 5x75 G.H5 D 338 G.H5.09
Hydrophobic TM6 K 362 6x32 G.H5 L 354 G.H5.25
Hydrophobic TM2 N 60 2x39 G.H5 Y 351 G.H5.22
Van-der-waals TM2 N 60 2x39 G.H5 Y 351 G.H5.22
Hydrophobic ICL2 P 130 34x50 G.H5 I 344 G.H5.15
Van-der-waals ICL2 P 130 34x50 G.H5 I 344 G.H5.15
Hydrophobic TM3 R 123 3x50 G.H5 I 352 G.H5.23
Van-der-waals TM3 R 123 3x50 G.H5 I 352 G.H5.23
Polar ICL2 R 137 34x57 G.hns1 R 31 G.hns1.02
Ionic TM6 K 359 6x29 G.h4s6 E 319 G.h4s6.12
Polar TM6 K 359 6x29 G.h4s6 E 319 G.h4s6.12
Van-der-waals TM6 K 359 6x29 G.h4s6 E 319 G.h4s6.12
Hydrophobic ICL3 Q 226 - G.S6 S 322 G.S6.03
Polar TM3 S 126 3x53 G.H5 N 348 G.H5.19
Hydrophobic TM3 S 126 3x53 G.H5 N 348 G.H5.19
Van-der-waals TM3 S 126 3x53 G.H5 N 348 G.H5.19
Hydrophobic TM7 C 421 7x56 G.H5 G 353 G.H5.24
Van-der-waals TM7 C 421 7x56 G.H5 G 353 G.H5.24
Hydrophobic TM5 L 225 5x75 G.H5 F 335 G.H5.06
Van-der-waals TM5 L 225 5x75 G.H5 F 335 G.H5.06
Hydrophobic C-term K 444 - G.h3s5 I 261 G.h3s5.01
Van-der-waals C-term K 444 - G.h3s5 I 261 G.h3s5.01
Polar TM2 N 61 2x40 G.H5 Y 351 G.H5.22
Hydrophobic TM2 N 61 2x40 G.H5 Y 351 G.H5.22
Van-der-waals TM2 N 61 2x40 G.H5 Y 351 G.H5.22
Ionic C-term R 458 - G.H3 E 246 G.H3.04
Polar C-term R 458 - G.H3 E 246 G.H3.04
Hydrophobic C-term R 458 - G.H3 E 246 G.H3.04
Van-der-waals C-term R 458 - G.H3 E 246 G.H3.04
Polar TM6 T 366 6x36 G.H5 G 353 G.H5.24
Van-der-waals C-term C 460 - G.s4h3 E 237 G.s4h3.10
Hydrophobic TM5 T 215 5x65 G.H5 L 349 G.H5.20
Hydrophobic ICL2 A 135 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic TM5 L 222 5x72 G.h4s6 E 319 G.h4s6.12
Van-der-waals TM5 L 222 5x72 G.h4s6 E 319 G.h4s6.12
Polar C-term C 460 - G.H2 R 206 G.H2.01
Van-der-waals C-term C 460 - G.H2 R 206 G.H2.01
Hydrophobic ICL2 L 131 34x51 G.H5 F 337 G.H5.08
Van-der-waals ICL2 L 131 34x51 G.H5 F 337 G.H5.08
Hydrophobic TM5 L 222 5x72 G.S6 Y 321 G.S6.02
Van-der-waals TM5 L 222 5x72 G.S6 Y 321 G.S6.02
Hydrophobic ICL3 T 230 - G.H4 V 302 G.H4.08
Polar ICL3 Q 226 - G.h4s6 E 319 G.h4s6.12
Van-der-waals ICL3 Q 226 - G.h4s6 E 319 G.h4s6.12
Ionic ICL3 R 352 - G.H4 E 309 G.H4.16
Polar ICL3 R 352 - G.H4 E 309 G.H4.16
Hydrophobic ICL3 R 352 - G.H4 E 309 G.H4.16
Van-der-waals ICL3 R 352 - G.H4 E 309 G.H4.16
Hydrophobic ICL2 P 130 34x50 G.H5 T 341 G.H5.12
Van-der-waals ICL2 P 130 34x50 G.H5 T 341 G.H5.12
Hydrophobic ICL2 L 131 34x51 G.S3 L 195 G.S3.01
Van-der-waals ICL2 L 131 34x51 G.S3 L 195 G.S3.01
Hydrophobic ICL2 L 131 34x51 G.S1 I 34 G.S1.02
Polar C-term K 444 - G.H3 N 258 G.H3.16
Hydrophobic TM4 T 138 4x38 G.HN Q 28 G.HN.52
Hydrophobic TM5 L 225 5x75 G.H5 A 339 G.H5.10
Hydrophobic ICL2 L 131 34x51 G.H5 I 344 G.H5.15
Van-der-waals ICL2 L 131 34x51 G.H5 I 344 G.H5.15
Hydrophobic TM5 L 225 5x75 G.S6 Y 321 G.S6.02
Van-der-waals TM5 L 225 5x75 G.S6 Y 321 G.S6.02
Polar TM2 T 58 2x37 G.H5 Y 351 G.H5.22
Van-der-waals TM2 T 58 2x37 G.H5 Y 351 G.H5.22