G12 - M2 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 87.8

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.8
PAE mean: 13.6


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM5 S 213 5x65 G.H5 L 371 G.H5.16
Hydrophobic TM5 S 213 5x65 G.H5 L 375 G.H5.20
Ionic TM6 R 381 6x29 G.H5 D 368 G.H5.13
Polar TM6 R 381 6x29 G.H5 D 368 G.H5.13
Hydrophobic TM6 R 381 6x29 G.H5 D 368 G.H5.13
Van-der-waals TM6 R 381 6x29 G.H5 D 368 G.H5.13
Hydrophobic TM2 L 62 2x43 G.H5 M 379 G.H5.24
Van-der-waals TM2 L 62 2x43 G.H5 M 379 G.H5.24
Hydrophobic TM5 I 217 5x69 G.H5 D 368 G.H5.13
Ionic TM5 D 220 5x72 G.S6 H 348 G.S6.03
Hydrophobic TM3 C 124 3x53 G.H5 I 378 G.H5.23
Polar TM3 R 121 3x50 G.H5 I 378 G.H5.23
Hydrophobic TM3 R 121 3x50 G.H5 I 378 G.H5.23
Van-der-waals TM3 R 121 3x50 G.H5 I 378 G.H5.23
Hydrophobic ICL2 V 133 34x55 G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 V 133 34x55 G.hns1 R 56 G.hns1.03
Hydrophobic TM5 I 209 5x61 G.H5 L 380 G.H5.25
Van-der-waals TM6 R 381 6x29 G.H5 Q 381 G.H5.26
Hydrophobic TM3 V 125 3x54 G.H5 L 375 G.H5.20
Van-der-waals TM3 V 125 3x54 G.H5 L 375 G.H5.20
Hydrophobic ICL2 L 129 34x51 G.S1 V 58 G.S1.02
Hydrophobic TM6 R 381 6x29 G.H5 L 375 G.H5.20
Van-der-waals TM6 R 381 6x29 G.H5 L 375 G.H5.20
Hydrophobic TM7 A 441 7x54 G.H5 M 379 G.H5.24
Polar ICL2 P 128 34x50 G.H5 N 374 G.H5.19
Van-der-waals ICL2 P 128 34x50 G.H5 N 374 G.H5.19
Polar TM6 V 385 6x33 G.H5 L 380 G.H5.25
Hydrophobic TM6 V 385 6x33 G.H5 L 380 G.H5.25
Hydrophobic TM6 V 385 6x33 G.H5 Q 381 G.H5.26
Hydrophobic TM6 V 385 6x33 G.H5 L 375 G.H5.20
Hydrophobic ICL2 P 128 34x50 G.H5 L 371 G.H5.16
Hydrophobic TM5 I 217 5x69 G.H5 A 365 G.H5.10
Hydrophobic H8 N 444 8x47 G.H5 M 379 G.H5.24
Van-der-waals H8 N 444 8x47 G.H5 M 379 G.H5.24
Hydrophobic ICL2 V 133 34x55 G.hns1 R 55 G.hns1.02
Van-der-waals ICL2 V 133 34x55 G.hns1 R 55 G.hns1.02
Polar TM6 T 388 6x36 G.H5 L 380 G.H5.25
Hydrophobic TM6 T 388 6x36 G.H5 L 380 G.H5.25
Hydrophobic TM3 V 125 3x54 G.H5 L 371 G.H5.16
Hydrophobic TM6 R 381 6x29 G.H5 L 371 G.H5.16
Hydrophobic TM6 R 381 6x29 G.H5 Q 372 G.H5.17
Van-der-waals TM6 R 381 6x29 G.H5 Q 372 G.H5.17
Hydrophobic TM2 N 58 2x39 G.H5 I 378 G.H5.23
Van-der-waals TM2 N 58 2x39 G.H5 I 378 G.H5.23
Polar TM5 S 215 5x67 G.H5 D 368 G.H5.13
Hydrophobic TM3 R 121 3x50 G.H5 L 380 G.H5.25
Hydrophobic ICL2 L 129 34x51 G.H5 I 370 G.H5.15
Van-der-waals ICL2 L 129 34x51 G.H5 I 370 G.H5.15
Hydrophobic ICL2 L 129 34x51 G.S3 I 221 G.S3.01
Van-der-waals ICL2 L 129 34x51 G.S3 I 221 G.S3.01
Hydrophobic TM5 I 217 5x69 G.H5 H 364 G.H5.09
Hydrophobic TM3 V 125 3x54 G.H5 I 378 G.H5.23
Van-der-waals TM3 V 125 3x54 G.H5 I 378 G.H5.23
Hydrophobic ICL2 P 128 34x50 G.H5 I 370 G.H5.15
Van-der-waals ICL2 P 128 34x50 G.H5 I 370 G.H5.15
Polar TM3 C 124 3x53 G.H5 N 374 G.H5.19
Van-der-waals TM3 C 124 3x53 G.H5 N 374 G.H5.19
Hydrophobic ICL2 L 129 34x51 G.H5 F 363 G.H5.08
Hydrophobic ICL2 P 128 34x50 G.H5 K 367 G.H5.12
Hydrophobic TM6 I 389 6x37 G.H5 L 380 G.H5.25
Polar TM3 R 121 3x50 G.H5 M 379 G.H5.24
Hydrophobic TM5 I 217 5x69 G.S6 F 347 G.S6.02
Van-der-waals TM5 I 217 5x69 G.S6 F 347 G.S6.02
Hydrophobic TM7 Y 440 7x53 G.H5 M 379 G.H5.24
Van-der-waals TM7 Y 440 7x53 G.H5 M 379 G.H5.24
Hydrophobic TM6 K 384 6x32 G.H5 Q 381 G.H5.26
Hydrophobic H8 F 447 8x50 G.H5 M 379 G.H5.24
Van-der-waals H8 F 447 8x50 G.H5 M 379 G.H5.24
Hydrophobic TM6 I 392 6x40 G.H5 L 380 G.H5.25
Hydrophobic TM2 N 59 2x40 G.H5 M 379 G.H5.24
Van-der-waals TM2 N 59 2x40 G.H5 M 379 G.H5.24
Hydrophobic ICL2 L 129 34x51 G.H5 K 367 G.H5.12
Hydrophobic ICL2 P 132 34x54 G.H5 N 374 G.H5.19