G13 -
M3 receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 85.0
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.8
iPTM Score: 0.8
PAE mean: 13.0
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
Gβ,
Gγ,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Polar | TM6 | K | 488 | 6x32 | G.H5 | Q | 377 | G.H5.26 |
Hydrophobic | TM6 | K | 488 | 6x32 | G.H5 | Q | 377 | G.H5.26 |
Van-der-waals | TM6 | K | 488 | 6x32 | G.H5 | Q | 377 | G.H5.26 |
Hydrophobic | ICL3 | T | 273 | - | G.H4 | R | 320 | G.H4.05 |
Hydrophobic | TM5 | I | 254 | 5x61 | G.H5 | L | 376 | G.H5.25 |
Van-der-waals | TM5 | I | 254 | 5x61 | G.H5 | L | 376 | G.H5.25 |
Hydrophobic | TM3 | S | 169 | 3x53 | G.H5 | L | 374 | G.H5.23 |
Van-der-waals | TM3 | S | 169 | 3x53 | G.H5 | L | 374 | G.H5.23 |
Hydrophobic | ICL3 | Q | 269 | - | G.S6 | H | 344 | G.S6.03 |
Van-der-waals | ICL3 | Q | 269 | - | G.S6 | H | 344 | G.S6.03 |
Hydrophobic | TM5 | T | 258 | 5x65 | G.H5 | L | 371 | G.H5.20 |
Hydrophobic | TM5 | L | 268 | 5x75 | G.H5 | R | 360 | G.H5.09 |
Van-der-waals | TM5 | L | 268 | 5x75 | G.H5 | R | 360 | G.H5.09 |
Polar | ICL3 | Q | 474 | - | G.H4 | R | 331 | G.H4.16 |
Hydrophobic | ICL3 | R | 478 | - | G.H4 | R | 331 | G.H4.16 |
Van-der-waals | ICL3 | R | 478 | - | G.H4 | R | 331 | G.H4.16 |
Hydrophobic | TM7 | A | 545 | 7x54 | G.H5 | M | 375 | G.H5.24 |
Hydrophobic | TM3 | I | 170 | 3x54 | G.H5 | L | 367 | G.H5.16 |
Van-der-waals | TM3 | I | 170 | 3x54 | G.H5 | L | 367 | G.H5.16 |
Hydrophobic | ICL2 | L | 174 | 34x51 | G.H5 | K | 363 | G.H5.12 |
Hydrophobic | ICL2 | P | 173 | 34x50 | G.H5 | K | 363 | G.H5.12 |
Hydrophobic | C-term | L | 590 | - | G.H3 | N | 270 | G.H3.07 |
Hydrophobic | C-term | I | 580 | - | G.H3 | R | 279 | G.H3.16 |
Van-der-waals | C-term | I | 580 | - | G.H3 | R | 279 | G.H3.16 |
Polar | TM5 | L | 268 | 5x75 | G.S6 | H | 344 | G.S6.03 |
Polar | TM3 | R | 166 | 3x50 | G.H5 | L | 374 | G.H5.23 |
Hydrophobic | TM3 | R | 166 | 3x50 | G.H5 | L | 374 | G.H5.23 |
Van-der-waals | TM3 | R | 166 | 3x50 | G.H5 | L | 374 | G.H5.23 |
Polar | TM5 | R | 261 | 5x68 | G.H5 | Q | 377 | G.H5.26 |
Van-der-waals | TM5 | R | 261 | 5x68 | G.H5 | Q | 377 | G.H5.26 |
Hydrophobic | ICL2 | P | 173 | 34x50 | G.H5 | L | 367 | G.H5.16 |
Hydrophobic | TM2 | N | 103 | 2x39 | G.H5 | L | 374 | G.H5.23 |
Van-der-waals | TM2 | N | 103 | 2x39 | G.H5 | L | 374 | G.H5.23 |
Hydrophobic | TM5 | R | 261 | 5x68 | G.H5 | L | 371 | G.H5.20 |
Van-der-waals | TM5 | R | 261 | 5x68 | G.H5 | L | 371 | G.H5.20 |
Hydrophobic | TM7 | C | 547 | 7x56 | G.H5 | M | 375 | G.H5.24 |
Van-der-waals | TM7 | C | 547 | 7x56 | G.H5 | M | 375 | G.H5.24 |
Hydrophobic | C-term | L | 590 | - | G.H3 | E | 267 | G.H3.04 |
Van-der-waals | C-term | L | 590 | - | G.H3 | E | 267 | G.H3.04 |
Ionic | TM5 | E | 257 | 5x64 | G.H5 | K | 363 | G.H5.12 |
Hydrophobic | ICL2 | L | 174 | 34x51 | G.S3 | V | 216 | G.S3.01 |
Polar | ICL3 | Q | 474 | - | G.H4 | E | 328 | G.H4.13 |
Van-der-waals | ICL3 | Q | 474 | - | G.H4 | E | 328 | G.H4.13 |
Ionic | ICL3 | E | 274 | - | G.H4 | K | 324 | G.H4.09 |
Polar | ICL3 | E | 274 | - | G.H4 | K | 324 | G.H4.09 |
Hydrophobic | ICL3 | E | 274 | - | G.H4 | K | 324 | G.H4.09 |
Van-der-waals | ICL3 | E | 274 | - | G.H4 | K | 324 | G.H4.09 |
Hydrophobic | TM6 | L | 493 | 6x37 | G.H5 | L | 376 | G.H5.25 |
Hydrophobic | TM5 | R | 261 | 5x68 | G.H5 | L | 367 | G.H5.16 |
Van-der-waals | TM5 | R | 261 | 5x68 | G.H5 | L | 367 | G.H5.16 |
Ionic | TM5 | R | 261 | 5x68 | G.H5 | D | 364 | G.H5.13 |
Polar | TM5 | R | 261 | 5x68 | G.H5 | D | 364 | G.H5.13 |
Hydrophobic | TM5 | R | 261 | 5x68 | G.H5 | D | 364 | G.H5.13 |
Van-der-waals | TM5 | R | 261 | 5x68 | G.H5 | D | 364 | G.H5.13 |
Hydrophobic | H8 | N | 548 | 8x47 | G.H5 | M | 375 | G.H5.24 |
Van-der-waals | H8 | N | 548 | 8x47 | G.H5 | M | 375 | G.H5.24 |
Hydrophobic | TM7 | Y | 544 | 7x53 | G.H5 | M | 375 | G.H5.24 |
Van-der-waals | TM7 | Y | 544 | 7x53 | G.H5 | M | 375 | G.H5.24 |
Hydrophobic | TM3 | I | 170 | 3x54 | G.H5 | L | 376 | G.H5.25 |
Polar | TM3 | S | 169 | 3x53 | G.H5 | N | 370 | G.H5.19 |
Van-der-waals | TM3 | S | 169 | 3x53 | G.H5 | N | 370 | G.H5.19 |
Hydrophobic | ICL2 | L | 174 | 34x51 | G.H5 | F | 359 | G.H5.08 |
Van-der-waals | ICL2 | L | 174 | 34x51 | G.H5 | F | 359 | G.H5.08 |
Hydrophobic | TM1 | V | 95 | 1x59 | G.HN | M | 1 | G.HN.01 |
Hydrophobic | TM1 | K | 94 | 1x58 | G.HN | M | 1 | G.HN.01 |
Van-der-waals | TM1 | K | 94 | 1x58 | G.HN | M | 1 | G.HN.01 |
Hydrophobic | ICL2 | L | 174 | 34x51 | G.H5 | I | 366 | G.H5.15 |
Van-der-waals | ICL2 | L | 174 | 34x51 | G.H5 | I | 366 | G.H5.15 |
Polar | C-term | L | 590 | - | G.H2 | R | 230 | G.H2.04 |
Van-der-waals | C-term | L | 590 | - | G.H2 | R | 230 | G.H2.04 |
Hydrophobic | TM2 | L | 107 | 2x43 | G.H5 | M | 375 | G.H5.24 |
Polar | ICL3 | Q | 269 | - | G.S6 | L | 342 | G.S6.01 |
Hydrophobic | TM5 | L | 268 | 5x75 | G.S6 | H | 345 | G.S6.04 |
Van-der-waals | TM5 | L | 268 | 5x75 | G.S6 | H | 345 | G.S6.04 |
Hydrophobic | TM6 | K | 485 | 6x29 | G.H5 | Q | 377 | G.H5.26 |
Hydrophobic | ICL2 | A | 178 | 34x55 | G.hns1 | K | 46 | G.hns1.02 |
Hydrophobic | ICL3 | G | 272 | - | G.H4 | K | 324 | G.H4.09 |
Hydrophobic | ICL1 | K | 100 | 12x51 | G.HN | F | 4 | G.HN.04 |
Van-der-waals | ICL1 | K | 100 | 12x51 | G.HN | F | 4 | G.HN.04 |
Hydrophobic | TM5 | L | 265 | 5x72 | G.H5 | D | 364 | G.H5.13 |
Van-der-waals | TM5 | L | 265 | 5x72 | G.H5 | D | 364 | G.H5.13 |
Hydrophobic | C-term | F | 581 | - | G.H2 | K | 231 | G.H2.05 |
Van-der-waals | C-term | F | 581 | - | G.H2 | K | 231 | G.H2.05 |
Polar | C-term | R | 576 | - | G.H3 | R | 279 | G.H3.16 |
Hydrophobic | C-term | R | 576 | - | G.H3 | R | 279 | G.H3.16 |
Van-der-waals | C-term | R | 576 | - | G.H3 | R | 279 | G.H3.16 |
Hydrophobic | ICL2 | A | 178 | 34x55 | G.hns1 | R | 47 | G.hns1.03 |
Van-der-waals | ICL2 | A | 178 | 34x55 | G.hns1 | R | 47 | G.hns1.03 |
Van-der-waals | ICL3 | Q | 269 | - | G.h4s6 | P | 341 | G.h4s6.20 |
Hydrophobic | ICL2 | R | 177 | 34x54 | G.H5 | I | 366 | G.H5.15 |
Polar | C-term | Q | 577 | - | G.H3 | R | 279 | G.H3.16 |
Hydrophobic | C-term | Q | 577 | - | G.H3 | R | 279 | G.H3.16 |
Van-der-waals | C-term | Q | 577 | - | G.H3 | R | 279 | G.H3.16 |
Polar | TM5 | R | 261 | 5x68 | G.H5 | H | 368 | G.H5.17 |
Hydrophobic | TM5 | R | 261 | 5x68 | G.H5 | H | 368 | G.H5.17 |
Van-der-waals | TM5 | R | 261 | 5x68 | G.H5 | H | 368 | G.H5.17 |
Hydrophobic | C-term | L | 590 | - | G.H3 | I | 271 | G.H3.08 |
Hydrophobic | TM3 | I | 170 | 3x54 | G.H5 | L | 371 | G.H5.20 |
Van-der-waals | TM3 | I | 170 | 3x54 | G.H5 | L | 371 | G.H5.20 |
Polar | ICL3 | Q | 269 | - | G.H4 | R | 331 | G.H4.16 |
Van-der-waals | ICL3 | Q | 269 | - | G.H4 | R | 331 | G.H4.16 |
Polar | ICL3 | S | 271 | - | G.S6 | H | 344 | G.S6.03 |
Hydrophobic | ICL3 | S | 271 | - | G.S6 | H | 344 | G.S6.03 |
Van-der-waals | ICL3 | S | 271 | - | G.S6 | H | 344 | G.S6.03 |
Hydrophobic | TM3 | I | 170 | 3x54 | G.H5 | L | 374 | G.H5.23 |
Hydrophobic | ICL2 | L | 174 | 34x51 | G.H5 | V | 362 | G.H5.11 |
Hydrophobic | ICL2 | P | 173 | 34x50 | G.H5 | I | 366 | G.H5.15 |
Hydrophobic | TM3 | I | 170 | 3x54 | G.H5 | N | 370 | G.H5.19 |