Gi3 -
M4 receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 86.6
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.8
iPTM Score: 0.8
PAE mean: 11.9
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | ICL2 | L | 138 | 34x51 | G.H5 | I | 343 | G.H5.15 |
Van-der-waals | ICL2 | L | 138 | 34x51 | G.H5 | I | 343 | G.H5.15 |
Polar | TM5 | S | 224 | 5x67 | G.H5 | D | 341 | G.H5.13 |
Hydrophobic | TM5 | S | 224 | 5x67 | G.H5 | D | 341 | G.H5.13 |
Van-der-waals | TM5 | S | 224 | 5x67 | G.H5 | D | 341 | G.H5.13 |
Hydrophobic | TM3 | V | 134 | 3x54 | G.H5 | L | 348 | G.H5.20 |
Van-der-waals | TM3 | V | 134 | 3x54 | G.H5 | L | 348 | G.H5.20 |
Hydrophobic | ICL3 | P | 234 | - | G.H4 | E | 298 | G.H4.05 |
Van-der-waals | ICL3 | P | 234 | - | G.H4 | E | 298 | G.H4.05 |
Hydrophobic | TM3 | R | 130 | 3x50 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | ICL2 | P | 137 | 34x50 | G.H5 | I | 344 | G.H5.16 |
Van-der-waals | ICL2 | P | 137 | 34x50 | G.H5 | I | 344 | G.H5.16 |
Hydrophobic | TM6 | Q | 390 | 6x25 | G.h4s6 | E | 318 | G.h4s6.12 |
Van-der-waals | TM6 | Q | 390 | 6x25 | G.h4s6 | E | 318 | G.h4s6.12 |
Hydrophobic | TM5 | V | 226 | 5x69 | G.S6 | Y | 320 | G.S6.02 |
Hydrophobic | TM6 | R | 394 | 6x29 | G.H5 | L | 348 | G.H5.20 |
Van-der-waals | TM6 | R | 394 | 6x29 | G.H5 | L | 348 | G.H5.20 |
Hydrophobic | ICL3 | P | 234 | - | G.H4 | E | 297 | G.H4.04 |
Van-der-waals | ICL3 | P | 234 | - | G.H4 | E | 297 | G.H4.04 |
Polar | TM5 | E | 232 | 5x75 | G.H4 | Y | 296 | G.H4.03 |
Hydrophobic | TM5 | E | 232 | 5x75 | G.H4 | Y | 296 | G.H4.03 |
Van-der-waals | TM5 | E | 232 | 5x75 | G.H4 | Y | 296 | G.H4.03 |
Polar | TM6 | T | 401 | 6x36 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | TM6 | T | 401 | 6x36 | G.H5 | L | 353 | G.H5.25 |
Ionic | ICL3 | K | 387 | - | G.H4 | E | 308 | G.H4.16 |
Polar | ICL3 | K | 387 | - | G.H4 | E | 308 | G.H4.16 |
Hydrophobic | ICL3 | K | 387 | - | G.H4 | E | 308 | G.H4.16 |
Van-der-waals | ICL3 | K | 387 | - | G.H4 | E | 308 | G.H4.16 |
Hydrophobic | TM4 | T | 146 | 4x39 | G.HN | R | 24 | G.HN.48 |
Hydrophobic | TM3 | V | 134 | 3x54 | G.H5 | I | 344 | G.H5.16 |
Hydrophobic | TM5 | E | 232 | 5x75 | G.H4 | E | 297 | G.H4.04 |
Van-der-waals | TM5 | E | 232 | 5x75 | G.H4 | E | 297 | G.H4.04 |
Ionic | ICL3 | R | 386 | - | G.H4 | D | 309 | G.H4.17 |
Polar | ICL3 | R | 386 | - | G.H4 | D | 309 | G.H4.17 |
Van-der-waals | ICL3 | R | 386 | - | G.H4 | D | 309 | G.H4.17 |
Aromatic | TM6 | R | 394 | 6x29 | G.H5 | Y | 354 | G.H5.26 |
Hydrophobic | TM6 | R | 394 | 6x29 | G.H5 | Y | 354 | G.H5.26 |
Van-der-waals | TM6 | R | 394 | 6x29 | G.H5 | Y | 354 | G.H5.26 |
Polar | ICL2 | A | 142 | 34x55 | G.hns1 | K | 32 | G.hns1.03 |
Hydrophobic | ICL2 | A | 142 | 34x55 | G.hns1 | K | 32 | G.hns1.03 |
Van-der-waals | ICL2 | A | 142 | 34x55 | G.hns1 | K | 32 | G.hns1.03 |
Hydrophobic | TM3 | C | 133 | 3x53 | G.H5 | C | 351 | G.H5.23 |
Polar | TM4 | T | 146 | 4x39 | G.HN | E | 28 | G.HN.52 |
Hydrophobic | TM4 | T | 146 | 4x39 | G.HN | E | 28 | G.HN.52 |
Van-der-waals | TM4 | T | 146 | 4x39 | G.HN | E | 28 | G.HN.52 |
Ionic | TM6 | R | 394 | 6x29 | G.H5 | D | 341 | G.H5.13 |
Polar | TM6 | R | 394 | 6x29 | G.H5 | D | 341 | G.H5.13 |
Van-der-waals | TM6 | R | 394 | 6x29 | G.H5 | D | 341 | G.H5.13 |
Polar | TM6 | Q | 390 | 6x25 | G.h4s6 | K | 314 | G.h4s6.08 |
Van-der-waals | TM6 | Q | 390 | 6x25 | G.h4s6 | K | 314 | G.h4s6.08 |
Ionic | TM5 | H | 229 | 5x72 | G.H5 | D | 337 | G.H5.09 |
Van-der-waals | ICL3 | K | 387 | - | G.H4 | Q | 304 | G.H4.12 |
Polar | H8 | N | 457 | 8x47 | G.H5 | E | 350 | G.H5.22 |
Van-der-waals | H8 | N | 457 | 8x47 | G.H5 | E | 350 | G.H5.22 |
Hydrophobic | TM6 | V | 398 | 6x33 | G.H5 | Y | 354 | G.H5.26 |
Hydrophobic | ICL3 | G | 233 | - | G.H4 | E | 297 | G.H4.04 |
Van-der-waals | ICL3 | G | 233 | - | G.H4 | E | 297 | G.H4.04 |
Polar | ICL3 | R | 386 | - | G.H4 | E | 308 | G.H4.16 |
Hydrophobic | TM6 | I | 405 | 6x40 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | ICL3 | K | 237 | - | G.H4 | Y | 302 | G.H4.10 |
Hydrophobic | TM5 | V | 226 | 5x69 | G.H5 | D | 341 | G.H5.13 |
Hydrophobic | ICL2 | L | 138 | 34x51 | G.H5 | T | 340 | G.H5.12 |
Polar | TM3 | C | 133 | 3x53 | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | TM3 | C | 133 | 3x53 | G.H5 | N | 347 | G.H5.19 |
Van-der-waals | TM3 | C | 133 | 3x53 | G.H5 | N | 347 | G.H5.19 |
Polar | TM6 | Q | 390 | 6x25 | G.h4s6 | K | 317 | G.h4s6.11 |
Van-der-waals | TM6 | Q | 390 | 6x25 | G.h4s6 | K | 317 | G.h4s6.11 |
Aromatic | TM6 | K | 397 | 6x32 | G.H5 | Y | 354 | G.H5.26 |
Hydrophobic | TM6 | K | 397 | 6x32 | G.H5 | Y | 354 | G.H5.26 |
Van-der-waals | TM6 | K | 397 | 6x32 | G.H5 | Y | 354 | G.H5.26 |
Hydrophobic | TM5 | I | 218 | 5x61 | G.H5 | L | 348 | G.H5.20 |
Hydrophobic | TM6 | I | 402 | 6x37 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | TM5 | S | 222 | 5x65 | G.H5 | L | 348 | G.H5.20 |
Hydrophobic | ICL3 | P | 234 | - | G.H4 | A | 301 | G.H4.08 |
Hydrophobic | ICL3 | R | 386 | - | G.h4s6 | K | 314 | G.h4s6.08 |
Van-der-waals | ICL3 | R | 386 | - | G.h4s6 | K | 314 | G.h4s6.08 |
Hydrophobic | TM6 | R | 394 | 6x29 | G.H5 | I | 344 | G.H5.16 |
Van-der-waals | TM6 | R | 394 | 6x29 | G.H5 | I | 344 | G.H5.16 |
Hydrophobic | TM7 | C | 456 | 7x56 | G.H5 | G | 352 | G.H5.24 |
Van-der-waals | TM7 | C | 456 | 7x56 | G.H5 | G | 352 | G.H5.24 |
Hydrophobic | H8 | N | 457 | 8x47 | G.H5 | G | 352 | G.H5.24 |
Hydrophobic | TM6 | V | 398 | 6x33 | G.H5 | L | 348 | G.H5.20 |
Polar | ICL3 | N | 383 | - | G.H4 | E | 308 | G.H4.16 |
Hydrophobic | ICL3 | N | 383 | - | G.H4 | E | 308 | G.H4.16 |
Van-der-waals | ICL3 | N | 383 | - | G.H4 | E | 308 | G.H4.16 |
Hydrophobic | TM6 | R | 394 | 6x29 | G.H5 | K | 345 | G.H5.17 |
Hydrophobic | ICL2 | L | 138 | 34x51 | G.H5 | F | 336 | G.H5.08 |
Van-der-waals | ICL2 | L | 138 | 34x51 | G.H5 | F | 336 | G.H5.08 |
Hydrophobic | ICL2 | P | 137 | 34x50 | G.H5 | I | 343 | G.H5.15 |
Van-der-waals | ICL2 | P | 137 | 34x50 | G.H5 | I | 343 | G.H5.15 |
Ionic | ICL2 | R | 143 | 34x56 | G.s2s3 | D | 193 | G.s2s3.02 |
Polar | ICL2 | R | 143 | 34x56 | G.s2s3 | D | 193 | G.s2s3.02 |
Van-der-waals | ICL2 | R | 143 | 34x56 | G.s2s3 | D | 193 | G.s2s3.02 |
Aromatic | TM5 | H | 229 | 5x72 | G.H5 | F | 334 | G.H5.06 |
Hydrophobic | TM5 | H | 229 | 5x72 | G.H5 | F | 334 | G.H5.06 |
Van-der-waals | TM5 | H | 229 | 5x72 | G.H5 | F | 334 | G.H5.06 |
Ionic | C-term | R | 479 | - | G.h2s4 | E | 216 | G.h2s4.02 |
Polar | C-term | R | 479 | - | G.h2s4 | E | 216 | G.h2s4.02 |
Van-der-waals | C-term | R | 479 | - | G.h2s4 | E | 216 | G.h2s4.02 |
Hydrophobic | TM5 | I | 218 | 5x61 | G.H5 | L | 353 | G.H5.25 |
Polar | ICL2 | P | 137 | 34x50 | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | ICL2 | L | 138 | 34x51 | G.S3 | L | 194 | G.S3.01 |
Van-der-waals | ICL2 | L | 138 | 34x51 | G.S3 | L | 194 | G.S3.01 |
Ionic | ICL1 | R | 61 | 12x48 | G.HN | D | 20 | G.HN.44 |
Polar | ICL1 | R | 61 | 12x48 | G.HN | D | 20 | G.HN.44 |
Van-der-waals | ICL1 | R | 61 | 12x48 | G.HN | D | 20 | G.HN.44 |
Hydrophobic | ICL2 | L | 138 | 34x51 | G.s2s3 | K | 192 | G.s2s3.01 |
Hydrophobic | ICL2 | P | 137 | 34x50 | G.H5 | T | 340 | G.H5.12 |
Hydrophobic | TM5 | V | 226 | 5x69 | G.S6 | H | 322 | G.S6.04 |
Polar | TM2 | N | 67 | 2x39 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | TM2 | N | 67 | 2x39 | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | TM2 | N | 67 | 2x39 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | ICL2 | T | 139 | 34x52 | G.s2s3 | D | 193 | G.s2s3.02 |
Polar | TM5 | R | 225 | 5x68 | G.H5 | D | 341 | G.H5.13 |
Van-der-waals | TM5 | R | 225 | 5x68 | G.H5 | D | 341 | G.H5.13 |
Polar | ICL3 | K | 387 | - | G.S6 | T | 321 | G.S6.03 |
Hydrophobic | ICL3 | K | 387 | - | G.S6 | T | 321 | G.S6.03 |
Van-der-waals | ICL3 | K | 387 | - | G.S6 | T | 321 | G.S6.03 |
Hydrophobic | ICL1 | R | 61 | 12x48 | G.HN | L | 23 | G.HN.47 |
Polar | TM3 | R | 130 | 3x50 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | TM3 | R | 130 | 3x50 | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | TM3 | R | 130 | 3x50 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | ICL2 | T | 139 | 34x52 | G.s2s3 | K | 192 | G.s2s3.01 |
Van-der-waals | ICL2 | T | 139 | 34x52 | G.s2s3 | K | 192 | G.s2s3.01 |
Polar | ICL3 | N | 383 | - | G.H4 | C | 305 | G.H4.13 |
Hydrophobic | ICL3 | N | 383 | - | G.H4 | C | 305 | G.H4.13 |
Van-der-waals | ICL3 | N | 383 | - | G.H4 | C | 305 | G.H4.13 |
Polar | TM6 | V | 398 | 6x33 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | TM6 | V | 398 | 6x33 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM6 | V | 398 | 6x33 | G.H5 | L | 353 | G.H5.25 |