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M5 receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 86.6
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.8
iPTM Score: 0.8
PAE mean: 12.6
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Polar | TM6 | A | 440 | 6x33 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | TM6 | A | 440 | 6x33 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM6 | A | 440 | 6x33 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | TM7 | C | 498 | 7x56 | G.H5 | G | 352 | G.H5.24 |
Van-der-waals | TM7 | C | 498 | 7x56 | G.H5 | G | 352 | G.H5.24 |
Polar | H8 | R | 500 | 8x48 | G.h4s6 | N | 316 | G.h4s6.10 |
Van-der-waals | H8 | R | 500 | 8x48 | G.h4s6 | N | 316 | G.h4s6.10 |
Polar | ICL3 | Q | 231 | - | G.S6 | I | 319 | G.S6.01 |
Hydrophobic | ICL3 | Q | 231 | - | G.S6 | I | 319 | G.S6.01 |
Van-der-waals | ICL3 | Q | 231 | - | G.S6 | I | 319 | G.S6.01 |
Polar | TM3 | R | 128 | 3x50 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | TM3 | R | 128 | 3x50 | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | TM3 | R | 128 | 3x50 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | ICL2 | P | 135 | 34x50 | G.H5 | T | 340 | G.H5.12 |
Hydrophobic | TM4 | T | 143 | 4x38 | G.HN | I | 28 | G.HN.52 |
Hydrophobic | TM5 | T | 220 | 5x65 | G.H5 | L | 348 | G.H5.20 |
Polar | C-term | Y | 524 | - | G.H3 | K | 258 | G.H3.16 |
Hydrophobic | C-term | Y | 524 | - | G.H3 | K | 258 | G.H3.16 |
Van-der-waals | C-term | Y | 524 | - | G.H3 | K | 258 | G.H3.16 |
Hydrophobic | ICL2 | P | 135 | 34x50 | G.H5 | I | 343 | G.H5.15 |
Hydrophobic | C-term | Y | 524 | - | G.H3 | F | 259 | G.H3.17 |
Hydrophobic | TM5 | L | 227 | 5x72 | G.S6 | Y | 320 | G.S6.02 |
Van-der-waals | TM5 | L | 227 | 5x72 | G.S6 | Y | 320 | G.S6.02 |
Ionic | ICL3 | R | 429 | - | G.H4 | E | 309 | G.H4.16 |
Polar | ICL3 | R | 429 | - | G.H4 | E | 309 | G.H4.16 |
Hydrophobic | ICL3 | R | 429 | - | G.H4 | E | 309 | G.H4.16 |
Van-der-waals | ICL3 | R | 429 | - | G.H4 | E | 309 | G.H4.16 |
Hydrophobic | TM3 | I | 132 | 3x54 | G.H5 | L | 348 | G.H5.20 |
Van-der-waals | TM3 | I | 132 | 3x54 | G.H5 | L | 348 | G.H5.20 |
Hydrophobic | TM3 | I | 132 | 3x54 | G.H5 | I | 344 | G.H5.16 |
Hydrophobic | TM5 | I | 216 | 5x61 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | TM5 | L | 230 | 5x75 | G.H5 | D | 337 | G.H5.09 |
Van-der-waals | TM5 | L | 230 | 5x75 | G.H5 | D | 337 | G.H5.09 |
Polar | ICL3 | Q | 231 | - | G.h4s6 | E | 318 | G.h4s6.12 |
Van-der-waals | ICL3 | Q | 231 | - | G.h4s6 | E | 318 | G.h4s6.12 |
Ionic | TM6 | K | 436 | 6x29 | G.h4s6 | E | 318 | G.h4s6.12 |
Polar | TM6 | K | 436 | 6x29 | G.h4s6 | E | 318 | G.h4s6.12 |
Van-der-waals | TM6 | K | 436 | 6x29 | G.h4s6 | E | 318 | G.h4s6.12 |
Polar | TM6 | K | 439 | 6x32 | G.H5 | Y | 354 | G.H5.26 |
Hydrophobic | TM6 | K | 439 | 6x32 | G.H5 | Y | 354 | G.H5.26 |
Van-der-waals | TM6 | K | 439 | 6x32 | G.H5 | Y | 354 | G.H5.26 |
Hydrophobic | ICL2 | L | 136 | 34x51 | G.S3 | L | 195 | G.S3.01 |
Van-der-waals | ICL2 | L | 136 | 34x51 | G.S3 | L | 195 | G.S3.01 |
Hydrophobic | TM5 | L | 230 | 5x75 | G.S6 | Y | 320 | G.S6.02 |
Hydrophobic | C-term | W | 525 | - | G.H3 | F | 259 | G.H3.17 |
Hydrophobic | ICL3 | V | 236 | - | G.H4 | A | 302 | G.H4.08 |
Van-der-waals | ICL3 | V | 236 | - | G.H4 | A | 302 | G.H4.08 |
Hydrophobic | TM5 | L | 230 | 5x75 | G.H5 | D | 341 | G.H5.13 |
Polar | ICL3 | G | 232 | - | G.H4 | Q | 305 | G.H4.12 |
Polar | TM6 | K | 436 | 6x29 | G.H5 | Y | 354 | G.H5.26 |
Hydrophobic | TM6 | K | 436 | 6x29 | G.H5 | Y | 354 | G.H5.26 |
Van-der-waals | TM6 | K | 436 | 6x29 | G.H5 | Y | 354 | G.H5.26 |
Aromatic | C-term | W | 525 | - | G.H2 | H | 214 | G.H2.09 |
Hydrophobic | C-term | W | 525 | - | G.H2 | H | 214 | G.H2.09 |
Van-der-waals | C-term | W | 525 | - | G.H2 | H | 214 | G.H2.09 |
Hydrophobic | ICL2 | L | 136 | 34x51 | G.H5 | T | 340 | G.H5.12 |
Van-der-waals | ICL2 | L | 136 | 34x51 | G.H5 | T | 340 | G.H5.12 |
Polar | ICL2 | R | 139 | 34x54 | G.S1 | D | 33 | G.S1.01 |
Polar | ICL2 | R | 139 | 34x54 | G.hns1 | A | 31 | G.hns1.02 |
Van-der-waals | ICL2 | R | 139 | 34x54 | G.hns1 | A | 31 | G.hns1.02 |
Polar | TM5 | R | 223 | 5x68 | G.H5 | Y | 354 | G.H5.26 |
Hydrophobic | TM5 | R | 223 | 5x68 | G.H5 | Y | 354 | G.H5.26 |
Van-der-waals | TM5 | R | 223 | 5x68 | G.H5 | Y | 354 | G.H5.26 |
Hydrophobic | H8 | N | 499 | 8x47 | G.H5 | G | 352 | G.H5.24 |
Hydrophobic | ICL2 | L | 136 | 34x51 | G.H5 | I | 343 | G.H5.15 |
Van-der-waals | ICL2 | L | 136 | 34x51 | G.H5 | I | 343 | G.H5.15 |
Polar | TM6 | T | 443 | 6x36 | G.H5 | G | 352 | G.H5.24 |
Polar | ICL3 | Q | 231 | - | G.H4 | Q | 305 | G.H4.12 |
Van-der-waals | ICL3 | Q | 231 | - | G.H4 | Q | 305 | G.H4.12 |
Polar | ICL3 | G | 232 | - | G.S6 | C | 321 | G.S6.03 |
Polar | TM5 | L | 230 | 5x75 | G.S6 | C | 321 | G.S6.03 |
Ionic | TM5 | R | 223 | 5x68 | G.H5 | D | 341 | G.H5.13 |
Polar | TM5 | R | 223 | 5x68 | G.H5 | D | 341 | G.H5.13 |
Hydrophobic | TM5 | R | 223 | 5x68 | G.H5 | D | 341 | G.H5.13 |
Van-der-waals | TM5 | R | 223 | 5x68 | G.H5 | D | 341 | G.H5.13 |
Hydrophobic | TM6 | L | 444 | 6x37 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM6 | L | 444 | 6x37 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | ICL2 | A | 140 | 34x55 | G.hns1 | K | 32 | G.hns1.03 |
Hydrophobic | ICL2 | L | 136 | 34x51 | G.H5 | F | 336 | G.H5.08 |
Van-der-waals | ICL2 | L | 136 | 34x51 | G.H5 | F | 336 | G.H5.08 |
Hydrophobic | TM5 | R | 223 | 5x68 | G.H5 | A | 345 | G.H5.17 |
Van-der-waals | TM5 | R | 223 | 5x68 | G.H5 | A | 345 | G.H5.17 |
Hydrophobic | TM5 | L | 227 | 5x72 | G.H5 | D | 341 | G.H5.13 |
Hydrophobic | ICL3 | Q | 231 | - | G.S6 | Y | 320 | G.S6.02 |
Polar | ICL3 | Q | 425 | - | G.H4 | A | 306 | G.H4.13 |
Hydrophobic | ICL3 | Q | 425 | - | G.H4 | A | 306 | G.H4.13 |
Van-der-waals | ICL3 | Q | 425 | - | G.H4 | A | 306 | G.H4.13 |
Polar | H8 | N | 499 | 8x47 | G.H5 | G | 350 | G.H5.22 |
Van-der-waals | H8 | N | 499 | 8x47 | G.H5 | G | 350 | G.H5.22 |
Hydrophobic | ICL2 | P | 135 | 34x50 | G.H5 | I | 344 | G.H5.16 |
Van-der-waals | ICL2 | P | 135 | 34x50 | G.H5 | I | 344 | G.H5.16 |
Hydrophobic | TM5 | L | 227 | 5x72 | G.h4s6 | E | 318 | G.h4s6.12 |
Hydrophobic | TM5 | R | 223 | 5x68 | G.H5 | I | 344 | G.H5.16 |
Hydrophobic | TM4 | P | 144 | 4x39 | G.HN | I | 28 | G.HN.52 |
Hydrophobic | TM6 | T | 443 | 6x36 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM6 | T | 443 | 6x36 | G.H5 | L | 353 | G.H5.25 |
Polar | TM3 | S | 131 | 3x53 | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | TM3 | S | 131 | 3x53 | G.H5 | N | 347 | G.H5.19 |
Van-der-waals | TM3 | S | 131 | 3x53 | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | TM3 | I | 132 | 3x54 | G.H5 | N | 347 | G.H5.19 |
Van-der-waals | TM3 | I | 132 | 3x54 | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | TM5 | R | 223 | 5x68 | G.H5 | L | 348 | G.H5.20 |
Van-der-waals | ICL2 | R | 139 | 34x54 | G.H5 | I | 343 | G.H5.15 |