G12 -
α1A-adrenoceptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 80.4
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.8
iPTM Score: 0.7
PAE mean: 13.1
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
Gβ,
Gγ,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Polar | TM5 | E | 214 | 5x68 | G.H5 | Q | 372 | G.H5.17 |
Hydrophobic | TM5 | E | 214 | 5x68 | G.H5 | Q | 372 | G.H5.17 |
Van-der-waals | TM5 | E | 214 | 5x68 | G.H5 | Q | 372 | G.H5.17 |
Hydrophobic | TM5 | A | 211 | 5x65 | G.H5 | L | 375 | G.H5.20 |
Hydrophobic | C-term | C | 434 | - | H.HA | K | 103 | H.HA.17 |
Polar | ICL2 | P | 135 | 34x54 | G.hns1 | R | 56 | G.hns1.03 |
Hydrophobic | ICL2 | P | 135 | 34x54 | G.hns1 | R | 56 | G.hns1.03 |
Polar | C-term | K | 427 | - | H.HA | D | 113 | H.HA.27 |
Van-der-waals | C-term | K | 427 | - | H.HA | D | 113 | H.HA.27 |
Hydrophobic | ICL2 | P | 131 | 34x50 | G.H5 | L | 371 | G.H5.16 |
Hydrophobic | ICL3 | K | 223 | - | G.S6 | F | 347 | G.S6.02 |
Van-der-waals | ICL3 | K | 223 | - | G.S6 | F | 347 | G.S6.02 |
Hydrophobic | TM3 | V | 128 | 3x54 | G.H5 | L | 375 | G.H5.20 |
Van-der-waals | TM3 | V | 128 | 3x54 | G.H5 | L | 375 | G.H5.20 |
Hydrophobic | C-term | V | 432 | - | H.HA | K | 103 | H.HA.17 |
Hydrophobic | ICL2 | L | 132 | 34x51 | G.H5 | V | 366 | G.H5.11 |
Van-der-waals | C-term | L | 430 | - | H.HA | K | 114 | H.HA.28 |
Polar | TM6 | T | 273 | 6x36 | G.H5 | M | 379 | G.H5.24 |
Hydrophobic | TM6 | T | 273 | 6x36 | G.H5 | M | 379 | G.H5.24 |
Van-der-waals | TM6 | T | 273 | 6x36 | G.H5 | M | 379 | G.H5.24 |
Hydrophobic | ICL2 | P | 131 | 34x50 | G.H5 | K | 367 | G.H5.12 |
Hydrophobic | ICL3 | T | 224 | - | G.S6 | H | 348 | G.S6.03 |
Hydrophobic | C-term | L | 430 | - | H.HB | M | 132 | H.HB.10 |
Hydrophobic | C-term | K | 427 | - | H.HA | K | 114 | H.HA.28 |
Van-der-waals | C-term | K | 427 | - | H.HA | K | 114 | H.HA.28 |
Hydrophobic | C-term | F | 429 | - | H.hdhe | F | 173 | H.hdhe.01 |
Hydrophobic | C-term | F | 399 | - | G.h4s6 | R | 340 | G.h4s6.09 |
Van-der-waals | C-term | F | 399 | - | G.h4s6 | R | 340 | G.h4s6.09 |
Hydrophobic | TM5 | V | 207 | 5x61 | G.H5 | I | 378 | G.H5.23 |
Hydrophobic | TM3 | R | 124 | 3x50 | G.H5 | D | 377 | G.H5.22 |
Hydrophobic | TM6 | T | 273 | 6x36 | G.H5 | L | 380 | G.H5.25 |
Polar | C-term | S | 439 | - | H.hbhc | A | 138 | H.hbhc.02 |
Hydrophobic | C-term | S | 439 | - | H.hbhc | A | 138 | H.hbhc.02 |
Hydrophobic | C-term | V | 432 | - | H.HA | V | 107 | H.HA.21 |
Van-der-waals | C-term | V | 432 | - | H.HA | V | 107 | H.HA.21 |
Hydrophobic | C-term | V | 436 | - | H.hbhc | A | 138 | H.hbhc.02 |
Van-der-waals | C-term | V | 436 | - | H.hbhc | A | 138 | H.hbhc.02 |
Hydrophobic | C-term | F | 429 | - | H.HA | A | 111 | H.HA.25 |
Van-der-waals | C-term | F | 429 | - | H.HA | A | 111 | H.HA.25 |
Hydrophobic | TM3 | R | 124 | 3x50 | G.H5 | I | 378 | G.H5.23 |
Van-der-waals | TM3 | R | 124 | 3x50 | G.H5 | I | 378 | G.H5.23 |
Hydrophobic | TM5 | L | 218 | 5x72 | G.h4s6 | P | 345 | G.h4s6.20 |
Polar | C-term | F | 429 | - | G.s4h3 | R | 265 | G.s4h3.12 |
Hydrophobic | ICL2 | L | 132 | 34x51 | G.S1 | V | 58 | G.S1.02 |
Hydrophobic | C-term | Y | 386 | - | G.H3 | K | 284 | G.H3.16 |
Hydrophobic | TM7 | Y | 326 | 7x53 | G.H5 | L | 380 | G.H5.25 |
Van-der-waals | TM7 | Y | 326 | 7x53 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | C-term | W | 397 | - | G.H2 | Q | 236 | G.H2.05 |
Van-der-waals | C-term | W | 397 | - | G.H2 | Q | 236 | G.H2.05 |
Hydrophobic | TM6 | K | 269 | 6x32 | G.H5 | Q | 381 | G.H5.26 |
Van-der-waals | TM6 | K | 269 | 6x32 | G.H5 | Q | 381 | G.H5.26 |
Hydrophobic | ICL2 | P | 131 | 34x50 | G.H5 | I | 370 | G.H5.15 |
Van-der-waals | ICL2 | P | 131 | 34x50 | G.H5 | I | 370 | G.H5.15 |
Polar | TM4 | Q | 140 | 4x39 | G.hns1 | R | 55 | G.hns1.02 |
Hydrophobic | TM4 | Q | 140 | 4x39 | G.hns1 | R | 55 | G.hns1.02 |
Van-der-waals | TM4 | Q | 140 | 4x39 | G.hns1 | R | 55 | G.hns1.02 |
Hydrophobic | C-term | F | 399 | - | G.H3 | E | 278 | G.H3.10 |
Van-der-waals | C-term | F | 399 | - | G.H3 | E | 278 | G.H3.10 |
Hydrophobic | TM7 | S | 329 | 7x56 | G.H5 | L | 380 | G.H5.25 |
Van-der-waals | TM7 | S | 329 | 7x56 | G.H5 | L | 380 | G.H5.25 |
Polar | H8 | S | 330 | 8x47 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | H8 | S | 330 | 8x47 | G.H5 | L | 380 | G.H5.25 |
Polar | C-term | Y | 386 | - | G.h4s6 | R | 340 | G.h4s6.09 |
Hydrophobic | C-term | Y | 386 | - | G.h4s6 | R | 340 | G.h4s6.09 |
Van-der-waals | C-term | Y | 386 | - | G.h4s6 | R | 340 | G.h4s6.09 |
Hydrophobic | ICL2 | P | 135 | 34x54 | G.hns1 | R | 55 | G.hns1.02 |
Van-der-waals | ICL2 | P | 135 | 34x54 | G.hns1 | R | 55 | G.hns1.02 |
Hydrophobic | TM5 | E | 214 | 5x68 | G.H5 | L | 375 | G.H5.20 |
Polar | C-term | Q | 431 | - | G.s4h3 | R | 265 | G.s4h3.12 |
Hydrophobic | C-term | Q | 431 | - | G.s4h3 | R | 265 | G.s4h3.12 |
Van-der-waals | C-term | Q | 431 | - | G.s4h3 | R | 265 | G.s4h3.12 |
Polar | C-term | Y | 386 | - | G.H3 | N | 282 | G.H3.14 |
Van-der-waals | C-term | Y | 386 | - | G.H3 | N | 282 | G.H3.14 |
Hydrophobic | C-term | F | 429 | - | H.HA | K | 114 | H.HA.28 |
Van-der-waals | C-term | F | 429 | - | H.HA | K | 114 | H.HA.28 |
Hydrophobic | C-term | F | 429 | - | H.HA | L | 115 | H.HA.29 |
Van-der-waals | C-term | F | 429 | - | H.HA | L | 115 | H.HA.29 |
Polar | C-term | V | 379 | - | G.H3 | K | 284 | G.H3.16 |
Hydrophobic | C-term | V | 379 | - | G.H3 | K | 284 | G.H3.16 |
Van-der-waals | C-term | V | 379 | - | G.H3 | K | 284 | G.H3.16 |
Hydrophobic | TM3 | V | 128 | 3x54 | G.H5 | L | 371 | G.H5.16 |
Van-der-waals | TM3 | V | 128 | 3x54 | G.H5 | L | 371 | G.H5.16 |
Hydrophobic | TM3 | V | 128 | 3x54 | G.H5 | I | 378 | G.H5.23 |
Van-der-waals | TM3 | V | 128 | 3x54 | G.H5 | I | 378 | G.H5.23 |
Ionic | ICL3 | K | 223 | - | G.H5 | D | 368 | G.H5.13 |
Polar | ICL3 | K | 223 | - | G.H5 | D | 368 | G.H5.13 |
Van-der-waals | ICL3 | K | 223 | - | G.H5 | D | 368 | G.H5.13 |
Polar | C-term | R | 382 | - | G.H3 | K | 284 | G.H3.16 |
Van-der-waals | C-term | R | 382 | - | G.H3 | K | 284 | G.H3.16 |
Hydrophobic | ICL3 | D | 225 | - | G.S6 | H | 348 | G.S6.03 |
Hydrophobic | TM5 | E | 214 | 5x68 | G.H5 | D | 368 | G.H5.13 |
Van-der-waals | TM5 | E | 214 | 5x68 | G.H5 | D | 368 | G.H5.13 |
Van-der-waals | ICL3 | K | 223 | - | G.S6 | L | 346 | G.S6.01 |
Polar | ICL2 | T | 136 | 34x55 | G.hns1 | R | 56 | G.hns1.03 |
Hydrophobic | ICL2 | T | 136 | 34x55 | G.hns1 | R | 56 | G.hns1.03 |
Van-der-waals | ICL2 | T | 136 | 34x55 | G.hns1 | R | 56 | G.hns1.03 |
Polar | C-term | L | 430 | - | H.HA | D | 110 | H.HA.24 |
Hydrophobic | C-term | L | 430 | - | H.HA | D | 110 | H.HA.24 |
Van-der-waals | C-term | L | 430 | - | H.HA | D | 110 | H.HA.24 |
Hydrophobic | TM5 | L | 218 | 5x72 | G.H5 | Q | 372 | G.H5.17 |
Van-der-waals | TM5 | L | 218 | 5x72 | G.H5 | Q | 372 | G.H5.17 |
Hydrophobic | ICL2 | L | 132 | 34x51 | G.H5 | I | 370 | G.H5.15 |
Van-der-waals | ICL2 | L | 132 | 34x51 | G.H5 | I | 370 | G.H5.15 |
Hydrophobic | H8 | Q | 331 | 8x48 | G.H5 | Q | 381 | G.H5.26 |
Van-der-waals | H8 | Q | 331 | 8x48 | G.H5 | Q | 381 | G.H5.26 |
Hydrophobic | TM6 | A | 270 | 6x33 | G.H5 | M | 379 | G.H5.24 |
Van-der-waals | TM6 | A | 270 | 6x33 | G.H5 | M | 379 | G.H5.24 |
Hydrophobic | ICL3 | K | 223 | - | G.H5 | A | 365 | G.H5.10 |
Polar | TM7 | S | 329 | 7x56 | G.H5 | Q | 381 | G.H5.26 |
Hydrophobic | ICL2 | L | 132 | 34x51 | G.S3 | I | 221 | G.S3.01 |
Van-der-waals | ICL2 | L | 132 | 34x51 | G.S3 | I | 221 | G.S3.01 |
Aromatic | ICL3 | K | 223 | - | G.H5 | H | 364 | G.H5.09 |
Polar | TM6 | R | 266 | 6x29 | G.h4s6 | S | 343 | G.h4s6.12 |
Van-der-waals | TM6 | R | 266 | 6x29 | G.h4s6 | S | 343 | G.h4s6.12 |
Polar | TM3 | G | 127 | 3x53 | G.H5 | N | 374 | G.H5.19 |
Hydrophobic | TM3 | G | 127 | 3x53 | G.H5 | N | 374 | G.H5.19 |
Van-der-waals | TM3 | G | 127 | 3x53 | G.H5 | N | 374 | G.H5.19 |
Hydrophobic | ICL2 | L | 132 | 34x51 | G.H5 | K | 367 | G.H5.12 |
Polar | ICL3 | K | 223 | - | G.S6 | H | 348 | G.S6.03 |
Hydrophobic | ICL3 | K | 223 | - | G.S6 | H | 348 | G.S6.03 |
Van-der-waals | ICL3 | K | 223 | - | G.S6 | H | 348 | G.S6.03 |
Polar | C-term | T | 384 | - | G.H3 | K | 284 | G.H3.16 |
Van-der-waals | C-term | T | 384 | - | G.H3 | K | 284 | G.H3.16 |
Polar | C-term | Q | 431 | - | G.s4h3 | M | 262 | G.s4h3.09 |
Hydrophobic | C-term | Q | 431 | - | G.s4h3 | M | 262 | G.s4h3.09 |
Van-der-waals | C-term | Q | 431 | - | G.s4h3 | M | 262 | G.s4h3.09 |
Hydrophobic | C-term | G | 437 | - | H.hbhc | A | 138 | H.hbhc.02 |
Van-der-waals | C-term | G | 437 | - | H.hbhc | A | 138 | H.hbhc.02 |
Ionic | ICL3 | D | 225 | - | G.H4 | R | 329 | G.H4.09 |
Van-der-waals | ICL3 | D | 225 | - | G.H4 | R | 329 | G.H4.09 |
Hydrophobic | C-term | P | 438 | - | H.hbhc | A | 138 | H.hbhc.02 |
Hydrophobic | ICL2 | L | 132 | 34x51 | G.H5 | F | 363 | G.H5.08 |
Van-der-waals | ICL2 | L | 132 | 34x51 | G.H5 | F | 363 | G.H5.08 |
Hydrophobic | TM5 | V | 210 | 5x64 | G.H5 | L | 371 | G.H5.16 |
Polar | C-term | S | 428 | - | H.HA | K | 114 | H.HA.28 |
Hydrophobic | C-term | S | 428 | - | H.HA | K | 114 | H.HA.28 |
Van-der-waals | C-term | S | 428 | - | H.HA | K | 114 | H.HA.28 |
Hydrophobic | TM5 | E | 214 | 5x68 | G.H5 | L | 371 | G.H5.16 |
Van-der-waals | TM5 | E | 214 | 5x68 | G.H5 | L | 371 | G.H5.16 |