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α1A-adrenoceptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 81.6
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.8
iPTM Score: 0.7
PAE mean: 13.0
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
Gβ,
Gγ,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | TM5 | L | 218 | 5x72 | G.S6 | Y | 320 | G.S6.02 |
Aromatic | C-term | W | 397 | - | G.H2 | R | 209 | G.H2.04 |
Hydrophobic | C-term | W | 397 | - | G.H2 | R | 209 | G.H2.04 |
Van-der-waals | C-term | W | 397 | - | G.H2 | R | 209 | G.H2.04 |
Polar | TM6 | R | 266 | 6x29 | G.h4s6 | P | 315 | G.h4s6.09 |
Van-der-waals | TM6 | R | 266 | 6x29 | G.h4s6 | P | 315 | G.h4s6.09 |
Polar | TM6 | R | 266 | 6x29 | G.H5 | Y | 354 | G.H5.26 |
Hydrophobic | TM6 | R | 266 | 6x29 | G.H5 | Y | 354 | G.H5.26 |
Van-der-waals | TM6 | R | 266 | 6x29 | G.H5 | Y | 354 | G.H5.26 |
Hydrophobic | C-term | V | 394 | - | G.s4h3 | E | 237 | G.s4h3.10 |
Van-der-waals | C-term | V | 394 | - | G.s4h3 | E | 237 | G.s4h3.10 |
Hydrophobic | TM5 | E | 214 | 5x68 | G.H5 | I | 344 | G.H5.16 |
Van-der-waals | TM5 | E | 214 | 5x68 | G.H5 | I | 344 | G.H5.16 |
Hydrophobic | ICL2 | L | 132 | 34x51 | G.H5 | T | 340 | G.H5.12 |
Polar | C-term | G | 393 | - | G.H2 | R | 206 | G.H2.01 |
Van-der-waals | C-term | G | 393 | - | G.H2 | R | 206 | G.H2.01 |
Hydrophobic | C-term | K | 398 | - | G.s4h3 | D | 238 | G.s4h3.11 |
Polar | ICL3 | K | 223 | - | G.S6 | C | 321 | G.S6.03 |
Van-der-waals | ICL3 | K | 223 | - | G.S6 | C | 321 | G.S6.03 |
Hydrophobic | ICL3 | T | 224 | - | G.S6 | Y | 320 | G.S6.02 |
Hydrophobic | ICL2 | L | 132 | 34x51 | G.S3 | L | 195 | G.S3.01 |
Van-der-waals | ICL2 | L | 132 | 34x51 | G.S3 | L | 195 | G.S3.01 |
Polar | C-term | E | 396 | - | G.s4h3 | H | 236 | G.s4h3.09 |
Hydrophobic | C-term | E | 396 | - | G.s4h3 | H | 236 | G.s4h3.09 |
Van-der-waals | C-term | E | 396 | - | G.s4h3 | H | 236 | G.s4h3.09 |
Hydrophobic | TM3 | V | 128 | 3x54 | G.H5 | L | 348 | G.H5.20 |
Van-der-waals | TM3 | V | 128 | 3x54 | G.H5 | L | 348 | G.H5.20 |
Van-der-waals | ICL3 | T | 224 | - | G.H4 | Q | 305 | G.H4.12 |
Hydrophobic | TM5 | A | 211 | 5x65 | G.H5 | L | 348 | G.H5.20 |
Hydrophobic | C-term | E | 396 | - | G.s4h3 | L | 235 | G.s4h3.08 |
Van-der-waals | C-term | E | 396 | - | G.s4h3 | L | 235 | G.s4h3.08 |
Polar | TM6 | K | 269 | 6x32 | G.H5 | Y | 354 | G.H5.26 |
Hydrophobic | TM6 | K | 269 | 6x32 | G.H5 | Y | 354 | G.H5.26 |
Van-der-waals | TM6 | K | 269 | 6x32 | G.H5 | Y | 354 | G.H5.26 |
Hydrophobic | ICL3 | S | 227 | - | G.H4 | A | 302 | G.H4.08 |
Hydrophobic | TM6 | L | 274 | 6x37 | G.H5 | L | 353 | G.H5.25 |
Ionic | ICL3 | K | 223 | - | G.H5 | D | 341 | G.H5.13 |
Polar | ICL3 | K | 223 | - | G.H5 | D | 341 | G.H5.13 |
Hydrophobic | ICL3 | K | 223 | - | G.H5 | D | 341 | G.H5.13 |
Van-der-waals | ICL3 | K | 223 | - | G.H5 | D | 341 | G.H5.13 |
Hydrophobic | C-term | W | 397 | - | G.H3 | L | 250 | G.H3.08 |
Polar | TM4 | Q | 140 | 4x39 | G.HN | K | 24 | G.HN.48 |
Hydrophobic | TM4 | Q | 140 | 4x39 | G.HN | K | 24 | G.HN.48 |
Van-der-waals | TM4 | Q | 140 | 4x39 | G.HN | K | 24 | G.HN.48 |
Ionic | TM6 | R | 266 | 6x29 | G.h4s6 | E | 318 | G.h4s6.12 |
Polar | TM6 | R | 266 | 6x29 | G.h4s6 | E | 318 | G.h4s6.12 |
Hydrophobic | TM6 | R | 266 | 6x29 | G.h4s6 | E | 318 | G.h4s6.12 |
Van-der-waals | TM6 | R | 266 | 6x29 | G.h4s6 | E | 318 | G.h4s6.12 |
Hydrophobic | ICL3 | K | 223 | - | G.S6 | Y | 320 | G.S6.02 |
Van-der-waals | ICL3 | K | 223 | - | G.S6 | Y | 320 | G.S6.02 |
Hydrophobic | ICL3 | T | 224 | - | G.S6 | C | 321 | G.S6.03 |
Polar | C-term | K | 398 | - | G.s4h3 | E | 237 | G.s4h3.10 |
Hydrophobic | C-term | K | 398 | - | G.s4h3 | E | 237 | G.s4h3.10 |
Van-der-waals | C-term | K | 398 | - | G.s4h3 | E | 237 | G.s4h3.10 |
Hydrophobic | ICL2 | P | 131 | 34x50 | G.H5 | I | 343 | G.H5.15 |
Van-der-waals | ICL2 | P | 131 | 34x50 | G.H5 | I | 343 | G.H5.15 |
Hydrophobic | ICL2 | T | 136 | 34x55 | G.hns1 | K | 32 | G.hns1.03 |
Hydrophobic | TM5 | V | 210 | 5x64 | G.H5 | I | 344 | G.H5.16 |
Hydrophobic | TM6 | L | 262 | 6x25 | G.h4s6 | P | 315 | G.h4s6.09 |
Polar | TM3 | R | 124 | 3x50 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | TM3 | R | 124 | 3x50 | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | TM3 | R | 124 | 3x50 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | ICL2 | L | 132 | 34x51 | G.H5 | I | 343 | G.H5.15 |
Van-der-waals | ICL2 | L | 132 | 34x51 | G.H5 | I | 343 | G.H5.15 |
Hydrophobic | TM7 | S | 329 | 7x56 | G.H5 | G | 352 | G.H5.24 |
Van-der-waals | TM7 | S | 329 | 7x56 | G.H5 | G | 352 | G.H5.24 |
Ionic | TM6 | K | 263 | 6x26 | G.h4s6 | E | 318 | G.h4s6.12 |
Polar | TM6 | K | 263 | 6x26 | G.h4s6 | E | 318 | G.h4s6.12 |
Hydrophobic | TM6 | K | 263 | 6x26 | G.h4s6 | E | 318 | G.h4s6.12 |
Van-der-waals | TM6 | K | 263 | 6x26 | G.h4s6 | E | 318 | G.h4s6.12 |
Polar | C-term | W | 397 | - | G.H3 | E | 246 | G.H3.04 |
Hydrophobic | C-term | W | 397 | - | G.H3 | E | 246 | G.H3.04 |
Van-der-waals | C-term | W | 397 | - | G.H3 | E | 246 | G.H3.04 |
Polar | ICL3 | D | 225 | - | G.H4 | Q | 305 | G.H4.12 |
Hydrophobic | ICL2 | L | 132 | 34x51 | G.H5 | F | 336 | G.H5.08 |
Van-der-waals | ICL2 | L | 132 | 34x51 | G.H5 | F | 336 | G.H5.08 |
Van-der-waals | TM5 | L | 218 | 5x72 | G.H5 | Y | 354 | G.H5.26 |
Polar | TM7 | S | 329 | 7x56 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | C-term | V | 394 | - | G.H2 | R | 206 | G.H2.01 |
Van-der-waals | C-term | V | 394 | - | G.H2 | R | 206 | G.H2.01 |
Polar | TM6 | R | 266 | 6x29 | G.h4s6 | N | 316 | G.h4s6.10 |
Hydrophobic | C-term | F | 399 | - | G.H3 | M | 249 | G.H3.07 |
Van-der-waals | C-term | F | 399 | - | G.H3 | M | 249 | G.H3.07 |
Hydrophobic | TM3 | V | 128 | 3x54 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | ICL3 | T | 224 | - | G.S6 | I | 319 | G.S6.01 |
Van-der-waals | ICL3 | T | 224 | - | G.S6 | I | 319 | G.S6.01 |
Polar | ICL3 | K | 223 | - | G.H5 | D | 337 | G.H5.09 |
Hydrophobic | ICL3 | K | 223 | - | G.H5 | D | 337 | G.H5.09 |
Van-der-waals | ICL3 | K | 223 | - | G.H5 | D | 337 | G.H5.09 |
Polar | C-term | C | 395 | - | G.H2 | R | 206 | G.H2.01 |
Hydrophobic | C-term | C | 395 | - | G.H2 | R | 206 | G.H2.01 |
Polar | TM6 | A | 270 | 6x33 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | TM6 | A | 270 | 6x33 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM6 | A | 270 | 6x33 | G.H5 | L | 353 | G.H5.25 |
Polar | TM6 | T | 273 | 6x36 | G.H5 | G | 352 | G.H5.24 |
Hydrophobic | TM6 | T | 273 | 6x36 | G.H5 | G | 352 | G.H5.24 |
Van-der-waals | TM6 | T | 273 | 6x36 | G.H5 | G | 352 | G.H5.24 |
Hydrophobic | ICL2 | P | 131 | 34x50 | G.H5 | I | 344 | G.H5.16 |
Van-der-waals | ICL2 | P | 131 | 34x50 | G.H5 | I | 344 | G.H5.16 |
Polar | C-term | C | 395 | - | G.s4h3 | E | 237 | G.s4h3.10 |
Hydrophobic | C-term | C | 395 | - | G.s4h3 | E | 237 | G.s4h3.10 |
Van-der-waals | C-term | C | 395 | - | G.s4h3 | E | 237 | G.s4h3.10 |
Polar | C-term | E | 396 | - | G.s4h3 | E | 237 | G.s4h3.10 |
Hydrophobic | C-term | E | 396 | - | G.s4h3 | E | 237 | G.s4h3.10 |
Van-der-waals | C-term | E | 396 | - | G.s4h3 | E | 237 | G.s4h3.10 |
Hydrophobic | TM5 | L | 218 | 5x72 | G.h4s6 | E | 318 | G.h4s6.12 |
Hydrophobic | TM5 | V | 207 | 5x61 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM5 | V | 207 | 5x61 | G.H5 | L | 353 | G.H5.25 |
Polar | TM3 | G | 127 | 3x53 | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | TM3 | G | 127 | 3x53 | G.H5 | N | 347 | G.H5.19 |
Van-der-waals | TM3 | G | 127 | 3x53 | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | TM5 | E | 214 | 5x68 | G.H5 | L | 348 | G.H5.20 |
Hydrophobic | TM5 | V | 207 | 5x61 | G.H5 | L | 348 | G.H5.20 |
Hydrophobic | TM6 | T | 273 | 6x36 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM6 | T | 273 | 6x36 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | ICL3 | T | 224 | - | G.H4 | E | 309 | G.H4.16 |
Van-der-waals | ICL3 | T | 224 | - | G.H4 | E | 309 | G.H4.16 |