Gt1 -
α1A-adrenoceptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 74.0
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.6
iPTM Score: 0.5
PAE mean: 15.5
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Polar | ICL3 | H | 256 | - | G.H5 | A | 334 | G.H5.10 |
Hydrophobic | ICL3 | H | 256 | - | G.H5 | A | 334 | G.H5.10 |
Van-der-waals | ICL3 | H | 256 | - | G.H5 | A | 334 | G.H5.10 |
Ionic | TM6 | K | 263 | 6x26 | G.H5 | D | 337 | G.H5.13 |
Polar | TM6 | K | 263 | 6x26 | G.H5 | D | 337 | G.H5.13 |
Hydrophobic | TM6 | K | 263 | 6x26 | G.H5 | D | 337 | G.H5.13 |
Van-der-waals | TM6 | K | 263 | 6x26 | G.H5 | D | 337 | G.H5.13 |
Hydrophobic | ICL2 | L | 132 | 34x51 | G.S3 | L | 190 | G.S3.01 |
Van-der-waals | ICL2 | L | 132 | 34x51 | G.S3 | L | 190 | G.S3.01 |
Hydrophobic | TM2 | T | 61 | 2x39 | G.H5 | C | 347 | G.H5.23 |
Hydrophobic | C-term | M | 374 | - | G.hgh4 | D | 285 | G.hgh4.04 |
Van-der-waals | C-term | M | 374 | - | G.hgh4 | D | 285 | G.hgh4.04 |
Polar | ICL3 | H | 256 | - | G.H5 | F | 330 | G.H5.06 |
Aromatic | ICL3 | H | 256 | - | G.H5 | F | 330 | G.H5.06 |
Hydrophobic | ICL3 | H | 256 | - | G.H5 | F | 330 | G.H5.06 |
Van-der-waals | ICL3 | H | 256 | - | G.H5 | F | 330 | G.H5.06 |
Hydrophobic | TM3 | V | 128 | 3x54 | G.H5 | L | 344 | G.H5.20 |
Polar | ICL2 | T | 136 | 34x55 | G.hns1 | D | 26 | G.hns1.01 |
Hydrophobic | ICL2 | T | 136 | 34x55 | G.hns1 | D | 26 | G.hns1.01 |
Polar | C-term | Y | 386 | - | G.H3 | S | 248 | G.H3.11 |
Van-der-waals | C-term | Y | 386 | - | G.H3 | S | 248 | G.H3.11 |
Hydrophobic | TM6 | R | 266 | 6x29 | G.H5 | F | 350 | G.H5.26 |
Van-der-waals | TM6 | R | 266 | 6x29 | G.H5 | F | 350 | G.H5.26 |
Hydrophobic | C-term | I | 388 | - | G.H3 | R | 253 | G.H3.16 |
Van-der-waals | C-term | I | 388 | - | G.H3 | R | 253 | G.H3.16 |
Hydrophobic | TM6 | R | 266 | 6x29 | G.H5 | K | 341 | G.H5.17 |
Van-der-waals | TM6 | R | 266 | 6x29 | G.H5 | K | 341 | G.H5.17 |
Hydrophobic | ICL2 | L | 132 | 34x51 | G.H5 | I | 340 | G.H5.16 |
Ionic | H8 | E | 332 | 8x49 | G.H5 | K | 345 | G.H5.21 |
Polar | H8 | E | 332 | 8x49 | G.H5 | K | 345 | G.H5.21 |
Hydrophobic | H8 | E | 332 | 8x49 | G.H5 | K | 345 | G.H5.21 |
Van-der-waals | H8 | E | 332 | 8x49 | G.H5 | K | 345 | G.H5.21 |
Polar | TM2 | S | 59 | 2x37 | G.H5 | D | 346 | G.H5.22 |
Hydrophobic | TM3 | Y | 130 | 3x56 | G.hns1 | R | 28 | G.hns1.03 |
Ionic | ICL2 | R | 133 | 34x52 | G.HN | E | 24 | G.HN.52 |
Polar | ICL2 | R | 133 | 34x52 | G.HN | E | 24 | G.HN.52 |
Hydrophobic | ICL2 | R | 133 | 34x52 | G.HN | E | 24 | G.HN.52 |
Van-der-waals | ICL2 | R | 133 | 34x52 | G.HN | E | 24 | G.HN.52 |
Van-der-waals | TM6 | K | 269 | 6x32 | G.H5 | F | 350 | G.H5.26 |
Hydrophobic | C-term | W | 397 | - | G.h2s4 | F | 211 | G.h2s4.01 |
Van-der-waals | C-term | W | 397 | - | G.h2s4 | F | 211 | G.h2s4.01 |
Hydrophobic | TM6 | L | 274 | 6x37 | G.H5 | L | 349 | G.H5.25 |
Hydrophobic | ICL2 | P | 131 | 34x50 | G.H5 | I | 340 | G.H5.16 |
Hydrophobic | TM3 | G | 127 | 3x53 | G.H5 | L | 344 | G.H5.20 |
Hydrophobic | ICL1 | H | 56 | 12x49 | G.h4s6 | V | 312 | G.h4s6.10 |
Hydrophobic | TM3 | G | 127 | 3x53 | G.H5 | C | 347 | G.H5.23 |
Van-der-waals | TM3 | G | 127 | 3x53 | G.H5 | C | 347 | G.H5.23 |
Polar | H8 | Q | 331 | 8x48 | G.H5 | F | 350 | G.H5.26 |
Hydrophobic | C-term | V | 379 | - | G.h4s6 | M | 308 | G.h4s6.03 |
Van-der-waals | C-term | V | 379 | - | G.h4s6 | M | 308 | G.h4s6.03 |
Hydrophobic | C-term | C | 395 | - | G.H2 | I | 208 | G.H2.08 |
Van-der-waals | C-term | C | 395 | - | G.H2 | I | 208 | G.H2.08 |
Van-der-waals | C-term | W | 397 | - | G.H3 | S | 248 | G.H3.11 |
Ionic | ICL3 | H | 256 | - | G.H5 | D | 337 | G.H5.13 |
Hydrophobic | C-term | F | 399 | - | G.H2 | R | 201 | G.H2.01 |
Van-der-waals | C-term | F | 399 | - | G.H2 | R | 201 | G.H2.01 |
Polar | TM2 | T | 61 | 2x39 | G.H5 | D | 346 | G.H5.22 |
Hydrophobic | ICL2 | Y | 134 | 34x53 | G.H5 | C | 347 | G.H5.23 |
Van-der-waals | ICL2 | Y | 134 | 34x53 | G.H5 | C | 347 | G.H5.23 |
Hydrophobic | C-term | I | 377 | - | G.H3 | H | 244 | G.H3.07 |
Polar | C-term | Y | 386 | - | G.H3 | H | 252 | G.H3.15 |
Aromatic | C-term | Y | 386 | - | G.H3 | H | 252 | G.H3.15 |
Hydrophobic | C-term | Y | 386 | - | G.H3 | H | 252 | G.H3.15 |
Van-der-waals | C-term | Y | 386 | - | G.H3 | H | 252 | G.H3.15 |
Hydrophobic | TM3 | V | 128 | 3x54 | G.H5 | L | 349 | G.H5.25 |
Van-der-waals | TM3 | V | 128 | 3x54 | G.H5 | L | 349 | G.H5.25 |
Polar | ICL2 | R | 133 | 34x52 | G.hns1 | A | 27 | G.hns1.02 |
Hydrophobic | ICL2 | R | 133 | 34x52 | G.hns1 | A | 27 | G.hns1.02 |
Van-der-waals | ICL2 | R | 133 | 34x52 | G.hns1 | A | 27 | G.hns1.02 |
Hydrophobic | ICL3 | S | 229 | - | G.H5 | F | 330 | G.H5.06 |
Van-der-waals | ICL3 | S | 229 | - | G.H5 | F | 330 | G.H5.06 |
Hydrophobic | C-term | W | 397 | - | G.H3 | I | 249 | G.H3.12 |
Hydrophobic | TM3 | R | 124 | 3x50 | G.H5 | L | 349 | G.H5.25 |
Van-der-waals | TM3 | R | 124 | 3x50 | G.H5 | L | 349 | G.H5.25 |
Hydrophobic | ICL2 | R | 133 | 34x52 | G.hns1 | R | 28 | G.hns1.03 |
Van-der-waals | ICL2 | R | 133 | 34x52 | G.hns1 | R | 28 | G.hns1.03 |
Polar | ICL2 | P | 131 | 34x50 | G.H5 | N | 343 | G.H5.19 |
Hydrophobic | ICL2 | P | 131 | 34x50 | G.H5 | N | 343 | G.H5.19 |
Van-der-waals | ICL2 | P | 131 | 34x50 | G.H5 | N | 343 | G.H5.19 |
Hydrophobic | ICL3 | V | 259 | - | G.H5 | D | 337 | G.H5.13 |
Polar | TM3 | R | 124 | 3x50 | G.H5 | G | 348 | G.H5.24 |
Van-der-waals | TM3 | R | 124 | 3x50 | G.H5 | G | 348 | G.H5.24 |
Hydrophobic | ICL2 | I | 137 | 34x56 | G.hns1 | A | 27 | G.hns1.02 |
Van-der-waals | ICL2 | I | 137 | 34x56 | G.hns1 | A | 27 | G.hns1.02 |
Hydrophobic | ICL2 | L | 132 | 34x51 | G.S1 | V | 30 | G.S1.02 |
Van-der-waals | ICL2 | L | 132 | 34x51 | G.S1 | V | 30 | G.S1.02 |
Hydrophobic | TM6 | A | 270 | 6x33 | G.H5 | L | 349 | G.H5.25 |
Hydrophobic | C-term | W | 397 | - | G.H2 | K | 205 | G.H2.05 |
Hydrophobic | ICL2 | L | 132 | 34x51 | G.H5 | N | 343 | G.H5.19 |
Van-der-waals | ICL2 | L | 132 | 34x51 | G.H5 | N | 343 | G.H5.19 |
Polar | ICL2 | T | 136 | 34x55 | G.hns1 | A | 27 | G.hns1.02 |
Hydrophobic | ICL2 | T | 136 | 34x55 | G.hns1 | A | 27 | G.hns1.02 |
Van-der-waals | ICL2 | T | 136 | 34x55 | G.hns1 | A | 27 | G.hns1.02 |
Polar | TM3 | R | 124 | 3x50 | G.H5 | C | 347 | G.H5.23 |
Hydrophobic | ICL2 | L | 132 | 34x51 | G.H5 | I | 339 | G.H5.15 |
Van-der-waals | ICL2 | L | 132 | 34x51 | G.H5 | I | 339 | G.H5.15 |
Polar | TM7 | S | 329 | 7x56 | G.H5 | G | 348 | G.H5.24 |
Hydrophobic | TM6 | K | 263 | 6x26 | G.H5 | I | 340 | G.H5.16 |
Van-der-waals | TM6 | K | 263 | 6x26 | G.H5 | I | 340 | G.H5.16 |
Hydrophobic | C-term | F | 385 | - | G.H3 | S | 248 | G.H3.11 |
Hydrophobic | ICL3 | H | 256 | - | G.H5 | D | 333 | G.H5.09 |
Van-der-waals | ICL3 | H | 256 | - | G.H5 | D | 333 | G.H5.09 |