Go - α1B-adrenoceptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 71.4

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.7
PAE mean: 14.4


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM3 V 147 3x54 G.H5 L 353 G.H5.25
Hydrophobic TM5 L 237 5x72 G.H5 I 344 G.H5.16
Polar ICL1 R 74 12x48 G.HN L 23 G.HN.47
Hydrophobic ICL2 L 151 34x51 G.H5 T 340 G.H5.12
Polar TM6 K 291 6x32 G.H5 Y 354 G.H5.26
Hydrophobic TM6 K 291 6x32 G.H5 Y 354 G.H5.26
Van-der-waals TM6 K 291 6x32 G.H5 Y 354 G.H5.26
Hydrophobic ICL2 L 151 34x51 G.H5 I 343 G.H5.15
Hydrophobic TM5 T 233 5x68 G.H5 L 348 G.H5.20
Polar TM3 G 146 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 G 146 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 G 146 3x53 G.H5 N 347 G.H5.19
Ionic TM6 R 288 6x29 G.h4s6 E 318 G.h4s6.12
Polar TM6 R 288 6x29 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM6 R 288 6x29 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM6 R 288 6x29 G.h4s6 E 318 G.h4s6.12
Polar TM7 S 351 7x56 G.H5 G 350 G.H5.22
Polar ICL2 S 150 34x50 G.H5 N 347 G.H5.19
Hydrophobic ICL2 S 150 34x50 G.H5 N 347 G.H5.19
Van-der-waals ICL2 S 150 34x50 G.H5 N 347 G.H5.19
Hydrophobic TM4 R 159 4x39 G.HN K 24 G.HN.48
Van-der-waals TM4 R 159 4x39 G.HN K 24 G.HN.48
Hydrophobic ICL2 L 151 34x51 G.H5 F 336 G.H5.08
Ionic H8 R 357 8x52 G.h3s5 D 262 G.h3s5.02
Polar H8 R 357 8x52 G.h3s5 D 262 G.h3s5.02
Van-der-waals H8 R 357 8x52 G.h3s5 D 262 G.h3s5.02
Hydrophobic ICL2 P 154 34x54 G.hns1 K 32 G.hns1.03
Polar TM6 R 288 6x29 G.H5 Y 354 G.H5.26
Aromatic TM6 R 288 6x29 G.H5 Y 354 G.H5.26
Hydrophobic TM6 R 288 6x29 G.H5 Y 354 G.H5.26
Van-der-waals TM6 R 288 6x29 G.H5 Y 354 G.H5.26
Polar TM6 T 295 6x36 G.H5 G 352 G.H5.24
Hydrophobic TM6 T 295 6x36 G.H5 G 352 G.H5.24
Van-der-waals TM6 T 295 6x36 G.H5 G 352 G.H5.24
Polar H8 K 353 8x48 G.h4s6 N 316 G.h4s6.10
Hydrophobic H8 K 353 8x48 G.h4s6 N 316 G.h4s6.10
Van-der-waals H8 K 353 8x48 G.h4s6 N 316 G.h4s6.10
Hydrophobic TM5 T 234 5x69 G.H5 Y 354 G.H5.26
Ionic H8 K 353 8x48 G.h3s5 D 262 G.h3s5.02
Polar H8 K 353 8x48 G.h3s5 D 262 G.h3s5.02
Hydrophobic H8 K 353 8x48 G.h3s5 D 262 G.h3s5.02
Van-der-waals H8 K 353 8x48 G.h3s5 D 262 G.h3s5.02
Hydrophobic TM7 S 351 7x56 G.H5 G 352 G.H5.24
Hydrophobic TM3 V 147 3x54 G.H5 C 351 G.H5.23
Van-der-waals TM3 V 147 3x54 G.H5 C 351 G.H5.23
Hydrophobic TM4 R 159 4x39 G.HN I 28 G.HN.52
Hydrophobic TM5 A 230 5x65 G.H5 L 353 G.H5.25
Hydrophobic TM5 L 237 5x72 G.H5 Y 354 G.H5.26
Van-der-waals TM5 L 237 5x72 G.H5 Y 354 G.H5.26
Hydrophobic C-term Y 388 - G.H3 M 249 G.H3.07
Polar TM6 A 292 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM6 A 292 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 A 292 6x33 G.H5 L 353 G.H5.25
Polar TM3 R 143 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 143 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 V 147 3x54 G.H5 L 348 G.H5.20
Hydrophobic TM5 L 237 5x72 G.H5 A 345 G.H5.17
Hydrophobic TM6 T 295 6x36 G.H5 L 353 G.H5.25
Hydrophobic ICL2 S 150 34x50 G.H5 I 344 G.H5.16
Van-der-waals ICL2 S 150 34x50 G.H5 I 344 G.H5.16
Ionic ICL3 E 244 - G.S6 H 322 G.S6.04
Polar ICL3 E 244 - G.S6 H 322 G.S6.04
Hydrophobic ICL3 E 244 - G.S6 H 322 G.S6.04
Van-der-waals ICL3 E 244 - G.S6 H 322 G.S6.04
Hydrophobic TM5 L 237 5x72 G.H5 L 348 G.H5.20
Hydrophobic TM6 L 296 6x37 G.H5 L 353 G.H5.25
Van-der-waals TM6 L 296 6x37 G.H5 L 353 G.H5.25
Hydrophobic TM5 A 230 5x65 G.H5 L 348 G.H5.20
Van-der-waals TM5 A 230 5x65 G.H5 L 348 G.H5.20
Hydrophobic TM5 L 237 5x72 G.H5 D 341 G.H5.13
Van-der-waals TM5 L 237 5x72 G.H5 D 341 G.H5.13
Hydrophobic C-term L 441 - H.hbhc T 117 H.hbhc.05
Van-der-waals C-term L 441 - H.hbhc T 117 H.hbhc.05
Hydrophobic C-term A 443 - H.hbhc M 114 H.hbhc.02
Van-der-waals C-term A 443 - H.hbhc M 114 H.hbhc.02
Hydrophobic TM5 V 226 5x61 G.H5 L 353 G.H5.25
Van-der-waals TM5 V 226 5x61 G.H5 L 353 G.H5.25
Hydrophobic TM5 T 233 5x68 G.H5 I 344 G.H5.16
Van-der-waals TM5 T 233 5x68 G.H5 I 344 G.H5.16
Hydrophobic ICL3 V 241 - G.S6 Y 320 G.S6.02
Van-der-waals ICL3 V 241 - G.S6 Y 320 G.S6.02
Hydrophobic ICL2 S 150 34x50 G.H5 I 343 G.H5.15
Hydrophobic C-term F 444 - H.HA Q 79 H.HA.17
Van-der-waals C-term F 444 - H.HA Q 79 H.HA.17
Hydrophobic ICL2 L 151 34x51 G.S3 L 195 G.S3.01
Van-der-waals ICL2 L 151 34x51 G.S3 L 195 G.S3.01