Gs -
α1B-adrenoceptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 79.2
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.8
iPTM Score: 0.8
PAE mean: 12.1
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
Gβ,
Gγ,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Aromatic | TM3 | R | 143 | 3x50 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | TM3 | R | 143 | 3x50 | G.H5 | Y | 391 | G.H5.23 |
Van-der-waals | TM3 | R | 143 | 3x50 | G.H5 | Y | 391 | G.H5.23 |
Polar | TM5 | N | 236 | 5x71 | G.H5 | D | 381 | G.H5.13 |
Van-der-waals | TM5 | N | 236 | 5x71 | G.H5 | D | 381 | G.H5.13 |
Polar | TM6 | K | 291 | 6x32 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | TM6 | K | 291 | 6x32 | G.H5 | E | 392 | G.H5.24 |
Van-der-waals | TM6 | K | 291 | 6x32 | G.H5 | E | 392 | G.H5.24 |
Polar | C-term | S | 427 | - | H.hbhc | D | 139 | H.hbhc.03 |
Hydrophobic | C-term | S | 427 | - | H.hbhc | D | 139 | H.hbhc.03 |
Van-der-waals | C-term | S | 427 | - | H.hbhc | D | 139 | H.hbhc.03 |
Hydrophobic | ICL3 | M | 242 | - | G.H4 | L | 346 | G.H4.16 |
Polar | C-term | S | 417 | - | G.s4h3 | E | 259 | G.s4h3.10 |
Hydrophobic | C-term | S | 417 | - | G.s4h3 | E | 259 | G.s4h3.10 |
Van-der-waals | C-term | S | 417 | - | G.s4h3 | E | 259 | G.s4h3.10 |
Polar | TM3 | G | 146 | 3x53 | G.H5 | H | 387 | G.H5.19 |
Hydrophobic | TM3 | G | 146 | 3x53 | G.H5 | H | 387 | G.H5.19 |
Van-der-waals | TM3 | G | 146 | 3x53 | G.H5 | H | 387 | G.H5.19 |
Hydrophobic | C-term | S | 415 | - | G.s4h3 | D | 260 | G.s4h3.11 |
Van-der-waals | C-term | S | 415 | - | G.s4h3 | D | 260 | G.s4h3.11 |
Polar | ICL2 | S | 150 | 34x50 | G.H5 | Q | 384 | G.H5.16 |
Hydrophobic | ICL2 | S | 150 | 34x50 | G.H5 | Q | 384 | G.H5.16 |
Polar | C-term | Q | 418 | - | G.s4h3 | E | 259 | G.s4h3.10 |
Hydrophobic | C-term | Q | 418 | - | G.s4h3 | E | 259 | G.s4h3.10 |
Van-der-waals | C-term | Q | 418 | - | G.s4h3 | E | 259 | G.s4h3.10 |
Hydrophobic | TM5 | V | 226 | 5x61 | G.H5 | L | 388 | G.H5.20 |
Hydrophobic | ICL2 | L | 151 | 34x51 | G.H5 | F | 376 | G.H5.08 |
Van-der-waals | ICL2 | L | 151 | 34x51 | G.H5 | F | 376 | G.H5.08 |
Hydrophobic | C-term | Q | 418 | - | G.s4h3 | R | 258 | G.s4h3.09 |
Hydrophobic | TM7 | S | 351 | 7x56 | G.H5 | E | 392 | G.H5.24 |
Van-der-waals | TM7 | S | 351 | 7x56 | G.H5 | E | 392 | G.H5.24 |
Polar | ICL2 | L | 151 | 34x51 | G.S1 | H | 41 | G.S1.02 |
Hydrophobic | ICL2 | L | 151 | 34x51 | G.S1 | H | 41 | G.S1.02 |
Van-der-waals | ICL2 | L | 151 | 34x51 | G.S1 | H | 41 | G.S1.02 |
Hydrophobic | TM5 | V | 226 | 5x61 | G.H5 | L | 393 | G.H5.25 |
Van-der-waals | TM5 | V | 226 | 5x61 | G.H5 | L | 393 | G.H5.25 |
Polar | C-term | S | 417 | - | G.s4h3 | D | 260 | G.s4h3.11 |
Polar | TM5 | N | 236 | 5x71 | G.H5 | R | 385 | G.H5.17 |
Hydrophobic | TM6 | R | 288 | 6x29 | G.H5 | L | 394 | G.H5.26 |
Van-der-waals | TM6 | R | 288 | 6x29 | G.H5 | L | 394 | G.H5.26 |
Hydrophobic | TM6 | A | 292 | 6x33 | G.H5 | L | 393 | G.H5.25 |
Van-der-waals | TM6 | A | 292 | 6x33 | G.H5 | L | 393 | G.H5.25 |
Polar | C-term | S | 415 | - | G.s4h3 | E | 259 | G.s4h3.10 |
Hydrophobic | C-term | S | 415 | - | G.s4h3 | E | 259 | G.s4h3.10 |
Van-der-waals | C-term | S | 415 | - | G.s4h3 | E | 259 | G.s4h3.10 |
Hydrophobic | TM3 | V | 147 | 3x54 | G.H5 | Y | 391 | G.H5.23 |
Polar | ICL2 | S | 150 | 34x50 | G.H5 | R | 380 | G.H5.12 |
Van-der-waals | ICL2 | S | 150 | 34x50 | G.H5 | R | 380 | G.H5.12 |
Polar | ICL3 | G | 240 | - | G.h4s6 | S | 349 | G.h4s6.02 |
Hydrophobic | ICL3 | G | 240 | - | G.S6 | P | 361 | G.S6.03 |
Polar | C-term | G | 416 | - | G.s4h3 | E | 259 | G.s4h3.10 |
Hydrophobic | C-term | G | 416 | - | G.s4h3 | E | 259 | G.s4h3.10 |
Hydrophobic | ICL2 | L | 151 | 34x51 | G.S3 | V | 217 | G.S3.01 |
Hydrophobic | TM5 | V | 229 | 5x64 | G.H5 | Q | 384 | G.H5.16 |
Van-der-waals | TM5 | V | 229 | 5x64 | G.H5 | Q | 384 | G.H5.16 |
Polar | ICL2 | Q | 152 | 34x52 | G.s2s3 | D | 215 | G.s2s3.01 |
Hydrophobic | ICL3 | G | 240 | - | G.H4 | L | 346 | G.H4.16 |
Ionic | H8 | K | 356 | 8x51 | G.H5 | E | 392 | G.H5.24 |
Polar | H8 | K | 356 | 8x51 | G.H5 | E | 392 | G.H5.24 |
Polar | TM6 | K | 291 | 6x32 | G.H5 | L | 394 | G.H5.26 |
Hydrophobic | TM6 | K | 291 | 6x32 | G.H5 | L | 394 | G.H5.26 |
Van-der-waals | TM6 | K | 291 | 6x32 | G.H5 | L | 394 | G.H5.26 |
Hydrophobic | TM5 | T | 233 | 5x68 | G.H5 | D | 381 | G.H5.13 |
Polar | TM6 | R | 288 | 6x29 | G.h4s6 | Y | 358 | G.h4s6.20 |
Van-der-waals | TM6 | R | 288 | 6x29 | G.h4s6 | Y | 358 | G.h4s6.20 |
Hydrophobic | TM6 | L | 296 | 6x37 | G.H5 | L | 393 | G.H5.25 |
Polar | TM3 | V | 147 | 3x54 | G.H5 | Q | 384 | G.H5.16 |
Hydrophobic | TM3 | V | 147 | 3x54 | G.H5 | Q | 384 | G.H5.16 |
Van-der-waals | TM3 | V | 147 | 3x54 | G.H5 | Q | 384 | G.H5.16 |
Hydrophobic | ICL2 | P | 154 | 34x54 | G.hns1 | R | 38 | G.hns1.02 |
Van-der-waals | ICL2 | P | 154 | 34x54 | G.hns1 | R | 38 | G.hns1.02 |
Hydrophobic | ICL2 | S | 150 | 34x50 | G.H5 | I | 383 | G.H5.15 |
Van-der-waals | ICL2 | S | 150 | 34x50 | G.H5 | I | 383 | G.H5.15 |
Hydrophobic | ICL3 | M | 242 | - | G.H4 | R | 347 | G.H4.17 |
Hydrophobic | TM5 | L | 237 | 5x72 | G.H5 | R | 385 | G.H5.17 |
Van-der-waals | TM5 | L | 237 | 5x72 | G.H5 | R | 385 | G.H5.17 |
Hydrophobic | TM3 | V | 147 | 3x54 | G.H5 | H | 387 | G.H5.19 |
Ionic | ICL3 | K | 243 | - | G.hgh4 | D | 323 | G.hgh4.13 |
Polar | ICL3 | K | 243 | - | G.hgh4 | D | 323 | G.hgh4.13 |
Hydrophobic | ICL3 | K | 243 | - | G.hgh4 | D | 323 | G.hgh4.13 |
Van-der-waals | ICL3 | K | 243 | - | G.hgh4 | D | 323 | G.hgh4.13 |
Hydrophobic | TM2 | T | 80 | 2x39 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | ICL2 | Q | 152 | 34x52 | G.S3 | V | 217 | G.S3.01 |
Van-der-waals | ICL2 | Q | 152 | 34x52 | G.S3 | V | 217 | G.S3.01 |
Hydrophobic | C-term | L | 414 | - | G.H3 | N | 271 | G.H3.07 |
Hydrophobic | TM5 | T | 233 | 5x68 | G.H5 | R | 385 | G.H5.17 |
Van-der-waals | TM5 | T | 233 | 5x68 | G.H5 | R | 385 | G.H5.17 |
Hydrophobic | ICL2 | L | 151 | 34x51 | G.S3 | F | 219 | G.S3.03 |
Polar | ICL3 | M | 242 | - | G.h4s6 | T | 350 | G.h4s6.03 |
Van-der-waals | ICL3 | M | 242 | - | G.h4s6 | T | 350 | G.h4s6.03 |
Hydrophobic | ICL3 | G | 240 | - | G.S6 | C | 359 | G.S6.01 |
Van-der-waals | ICL3 | G | 240 | - | G.S6 | C | 359 | G.S6.01 |
Polar | TM6 | T | 295 | 6x36 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | TM6 | T | 295 | 6x36 | G.H5 | E | 392 | G.H5.24 |
Van-der-waals | TM6 | T | 295 | 6x36 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | TM5 | A | 230 | 5x65 | G.H5 | L | 388 | G.H5.20 |
Polar | TM5 | T | 233 | 5x68 | G.H5 | Q | 384 | G.H5.16 |
Van-der-waals | TM5 | T | 233 | 5x68 | G.H5 | Q | 384 | G.H5.16 |
Hydrophobic | TM5 | L | 237 | 5x72 | G.h4s6 | Y | 358 | G.h4s6.20 |
Van-der-waals | TM5 | L | 237 | 5x72 | G.h4s6 | Y | 358 | G.h4s6.20 |
Hydrophobic | ICL2 | L | 151 | 34x51 | G.H5 | C | 379 | G.H5.11 |
Hydrophobic | C-term | S | 425 | - | H.hbhc | P | 138 | H.hbhc.02 |
Van-der-waals | C-term | S | 425 | - | H.hbhc | P | 138 | H.hbhc.02 |
Hydrophobic | ICL2 | P | 154 | 34x54 | G.hns1 | A | 39 | G.hns1.03 |
Hydrophobic | TM5 | T | 233 | 5x68 | G.H5 | L | 388 | G.H5.20 |
Aromatic | ICL2 | Y | 153 | 34x53 | G.H5 | H | 387 | G.H5.19 |
Hydrophobic | ICL2 | Y | 153 | 34x53 | G.H5 | H | 387 | G.H5.19 |
Hydrophobic | ICL2 | L | 151 | 34x51 | G.H5 | R | 380 | G.H5.12 |
Hydrophobic | ICL2 | L | 151 | 34x51 | G.H5 | I | 383 | G.H5.15 |
Van-der-waals | ICL2 | L | 151 | 34x51 | G.H5 | I | 383 | G.H5.15 |
Hydrophobic | TM3 | V | 147 | 3x54 | G.H5 | L | 388 | G.H5.20 |
Hydrophobic | ICL2 | T | 155 | 34x55 | G.hns1 | A | 39 | G.hns1.03 |
Van-der-waals | ICL2 | T | 155 | 34x55 | G.hns1 | A | 39 | G.hns1.03 |
Hydrophobic | C-term | L | 414 | - | G.H3 | E | 268 | G.H3.04 |
Van-der-waals | C-term | L | 414 | - | G.H3 | E | 268 | G.H3.04 |
Hydrophobic | TM6 | T | 295 | 6x36 | G.H5 | L | 393 | G.H5.25 |
Van-der-waals | TM6 | T | 295 | 6x36 | G.H5 | L | 393 | G.H5.25 |
Hydrophobic | ICL3 | V | 241 | - | G.h4s6 | T | 350 | G.h4s6.03 |
Hydrophobic | ICL3 | M | 242 | - | G.H4 | D | 343 | G.H4.13 |
Polar | C-term | Y | 386 | - | G.h3s5 | R | 283 | G.h3s5.01 |
Hydrophobic | TM5 | L | 237 | 5x72 | G.H5 | L | 394 | G.H5.26 |
Van-der-waals | C-term | S | 415 | - | G.s4h3 | I | 257 | G.s4h3.08 |