G12 -
α1D-adrenoceptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 68.7
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.6
iPTM Score: 0.6
PAE mean: 14.6
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | TM6 | T | 349 | 6x36 | G.H5 | I | 378 | G.H5.23 |
Van-der-waals | TM6 | T | 349 | 6x36 | G.H5 | I | 378 | G.H5.23 |
Hydrophobic | TM3 | V | 198 | 3x54 | G.H5 | L | 371 | G.H5.16 |
Van-der-waals | TM3 | V | 198 | 3x54 | G.H5 | L | 371 | G.H5.16 |
Hydrophobic | C-term | I | 572 | - | H.HD | E | 172 | H.HD.12 |
Hydrophobic | C-term | L | 544 | - | G.h2s4 | D | 243 | G.h2s4.02 |
Hydrophobic | C-term | D | 563 | - | G.s4h3 | E | 263 | G.s4h3.10 |
Van-der-waals | C-term | D | 563 | - | G.s4h3 | E | 263 | G.s4h3.10 |
Hydrophobic | C-term | Y | 564 | - | G.s4h3 | D | 264 | G.s4h3.11 |
Polar | ICL3 | K | 293 | - | G.S6 | F | 350 | G.S6.05 |
Van-der-waals | ICL3 | K | 293 | - | G.S6 | F | 350 | G.S6.05 |
Polar | C-term | A | 541 | - | G.H2 | Q | 240 | G.H2.09 |
Hydrophobic | C-term | A | 541 | - | G.H2 | Q | 240 | G.H2.09 |
Van-der-waals | C-term | A | 541 | - | G.H2 | Q | 240 | G.H2.09 |
Hydrophobic | ICL3 | V | 292 | - | G.S6 | H | 348 | G.S6.03 |
Polar | C-term | Y | 564 | - | G.s4h3 | E | 263 | G.s4h3.10 |
Hydrophobic | C-term | Y | 564 | - | G.s4h3 | E | 263 | G.s4h3.10 |
Van-der-waals | C-term | Y | 564 | - | G.s4h3 | E | 263 | G.s4h3.10 |
Ionic | N-term | E | 12 | - | G.HN | R | 30 | G.HN.30 |
Polar | N-term | E | 12 | - | G.HN | R | 30 | G.HN.30 |
Van-der-waals | N-term | E | 12 | - | G.HN | R | 30 | G.HN.30 |
Hydrophobic | C-term | V | 542 | - | G.H2 | Q | 240 | G.H2.09 |
Van-der-waals | C-term | V | 542 | - | G.H2 | Q | 240 | G.H2.09 |
Polar | H8 | R | 407 | 8x48 | G.H5 | Q | 381 | G.H5.26 |
Hydrophobic | H8 | R | 407 | 8x48 | G.H5 | Q | 381 | G.H5.26 |
Van-der-waals | H8 | R | 407 | 8x48 | G.H5 | Q | 381 | G.H5.26 |
Hydrophobic | TM5 | T | 284 | 5x68 | G.H5 | L | 371 | G.H5.16 |
Van-der-waals | TM5 | T | 284 | 5x68 | G.H5 | L | 371 | G.H5.16 |
Hydrophobic | C-term | D | 563 | - | G.s3h2 | Q | 231 | G.s3h2.03 |
Hydrophobic | ICL2 | L | 202 | 34x51 | G.H5 | K | 367 | G.H5.12 |
Van-der-waals | ICL2 | L | 202 | 34x51 | G.H5 | K | 367 | G.H5.12 |
Polar | TM5 | S | 287 | 5x71 | G.H5 | D | 368 | G.H5.13 |
Van-der-waals | TM5 | S | 287 | 5x71 | G.H5 | D | 368 | G.H5.13 |
Hydrophobic | TM3 | V | 198 | 3x54 | G.H5 | L | 375 | G.H5.20 |
Van-der-waals | TM3 | V | 198 | 3x54 | G.H5 | L | 375 | G.H5.20 |
Polar | TM3 | R | 194 | 3x50 | G.H5 | I | 378 | G.H5.23 |
Hydrophobic | TM3 | R | 194 | 3x50 | G.H5 | I | 378 | G.H5.23 |
Van-der-waals | TM3 | R | 194 | 3x50 | G.H5 | I | 378 | G.H5.23 |
Hydrophobic | C-term | L | 544 | - | G.H2 | Q | 240 | G.H2.09 |
Van-der-waals | C-term | L | 544 | - | G.H2 | Q | 240 | G.H2.09 |
Polar | C-term | T | 570 | - | H.HA | K | 114 | H.HA.28 |
Hydrophobic | C-term | T | 570 | - | H.HA | K | 114 | H.HA.28 |
Van-der-waals | C-term | T | 570 | - | H.HA | K | 114 | H.HA.28 |
Polar | C-term | T | 570 | - | H.HA | D | 110 | H.HA.24 |
Hydrophobic | C-term | T | 570 | - | H.HA | D | 110 | H.HA.24 |
Van-der-waals | C-term | T | 570 | - | H.HA | D | 110 | H.HA.24 |
Polar | ICL1 | Q | 128 | 12x51 | G.hns1 | R | 55 | G.hns1.02 |
Van-der-waals | ICL1 | Q | 128 | 12x51 | G.hns1 | R | 55 | G.hns1.02 |
Hydrophobic | C-term | E | 569 | - | H.HA | V | 107 | H.HA.21 |
Van-der-waals | C-term | E | 569 | - | H.HA | V | 107 | H.HA.21 |
Hydrophobic | C-term | T | 570 | - | H.hdhe | F | 173 | H.hdhe.01 |
Polar | ICL2 | K | 203 | 34x52 | G.s2s3 | K | 219 | G.s2s3.01 |
Polar | ICL2 | S | 201 | 34x50 | G.H5 | K | 367 | G.H5.12 |
Van-der-waals | ICL2 | S | 201 | 34x50 | G.H5 | K | 367 | G.H5.12 |
Polar | TM3 | G | 197 | 3x53 | G.H5 | N | 374 | G.H5.19 |
Hydrophobic | TM3 | G | 197 | 3x53 | G.H5 | N | 374 | G.H5.19 |
Van-der-waals | TM3 | G | 197 | 3x53 | G.H5 | N | 374 | G.H5.19 |
Hydrophobic | C-term | T | 570 | - | H.HA | A | 111 | H.HA.25 |
Hydrophobic | ICL2 | K | 203 | 34x52 | G.S3 | I | 221 | G.S3.01 |
Polar | C-term | E | 569 | - | G.s4h3 | R | 265 | G.s4h3.12 |
Hydrophobic | C-term | E | 569 | - | G.s4h3 | R | 265 | G.s4h3.12 |
Van-der-waals | C-term | E | 569 | - | G.s4h3 | R | 265 | G.s4h3.12 |
Polar | ICL2 | P | 205 | 34x54 | G.hns1 | R | 56 | G.hns1.03 |
Hydrophobic | ICL2 | P | 205 | 34x54 | G.hns1 | R | 56 | G.hns1.03 |
Van-der-waals | ICL2 | P | 205 | 34x54 | G.hns1 | R | 56 | G.hns1.03 |
Ionic | TM4 | E | 210 | 4x39 | G.HN | R | 52 | G.HN.52 |
Polar | TM4 | E | 210 | 4x39 | G.HN | R | 52 | G.HN.52 |
Van-der-waals | TM4 | E | 210 | 4x39 | G.HN | R | 52 | G.HN.52 |
Hydrophobic | TM5 | L | 288 | 5x72 | G.H5 | D | 368 | G.H5.13 |
Hydrophobic | TM6 | L | 350 | 6x37 | G.H5 | I | 378 | G.H5.23 |
Hydrophobic | C-term | I | 572 | - | H.HA | L | 115 | H.HA.29 |
Van-der-waals | C-term | I | 572 | - | H.HA | L | 115 | H.HA.29 |
Ionic | C-term | E | 569 | - | H.HA | K | 103 | H.HA.17 |
Polar | C-term | E | 569 | - | H.HA | K | 103 | H.HA.17 |
Hydrophobic | C-term | E | 569 | - | H.HA | K | 103 | H.HA.17 |
Van-der-waals | C-term | E | 569 | - | H.HA | K | 103 | H.HA.17 |
Ionic | C-term | R | 536 | - | H.HA | E | 92 | H.HA.06 |
Polar | C-term | R | 536 | - | H.HA | E | 92 | H.HA.06 |
Hydrophobic | C-term | R | 536 | - | H.HA | E | 92 | H.HA.06 |
Van-der-waals | C-term | R | 536 | - | H.HA | E | 92 | H.HA.06 |
Hydrophobic | ICL2 | S | 201 | 34x50 | G.H5 | I | 370 | G.H5.15 |
Polar | C-term | D | 563 | - | G.H2 | S | 233 | G.H2.02 |
Hydrophobic | C-term | D | 563 | - | G.H2 | S | 233 | G.H2.02 |
Van-der-waals | C-term | D | 563 | - | G.H2 | S | 233 | G.H2.02 |
Polar | ICL2 | A | 206 | 34x55 | G.hns1 | R | 56 | G.hns1.03 |
Hydrophobic | ICL2 | A | 206 | 34x55 | G.hns1 | R | 56 | G.hns1.03 |
Van-der-waals | ICL2 | A | 206 | 34x55 | G.hns1 | R | 56 | G.hns1.03 |
Hydrophobic | ICL2 | P | 205 | 34x54 | G.hns1 | R | 55 | G.hns1.02 |
Van-der-waals | ICL2 | P | 205 | 34x54 | G.hns1 | R | 55 | G.hns1.02 |
Hydrophobic | TM5 | T | 284 | 5x68 | G.H5 | L | 375 | G.H5.20 |
Hydrophobic | TM4 | T | 209 | 4x38 | G.hns1 | R | 56 | G.hns1.03 |
Van-der-waals | TM4 | T | 209 | 4x38 | G.hns1 | R | 56 | G.hns1.03 |
Polar | C-term | D | 563 | - | G.H2 | R | 232 | G.H2.01 |
Van-der-waals | C-term | D | 563 | - | G.H2 | R | 232 | G.H2.01 |
Ionic | TM4 | E | 210 | 4x39 | G.hns1 | R | 55 | G.hns1.02 |
Polar | TM4 | E | 210 | 4x39 | G.hns1 | R | 55 | G.hns1.02 |
Van-der-waals | TM4 | E | 210 | 4x39 | G.hns1 | R | 55 | G.hns1.02 |
Hydrophobic | ICL2 | L | 202 | 34x51 | G.S1 | V | 58 | G.S1.02 |
Van-der-waals | ICL2 | L | 202 | 34x51 | G.S1 | V | 58 | G.S1.02 |
Polar | TM6 | T | 349 | 6x36 | G.H5 | M | 379 | G.H5.24 |
Hydrophobic | TM6 | T | 349 | 6x36 | G.H5 | M | 379 | G.H5.24 |
Van-der-waals | TM6 | T | 349 | 6x36 | G.H5 | M | 379 | G.H5.24 |
Polar | ICL3 | K | 293 | - | G.S6 | H | 349 | G.S6.04 |
Aromatic | ICL3 | K | 293 | - | G.S6 | H | 349 | G.S6.04 |
Hydrophobic | ICL3 | K | 293 | - | G.S6 | H | 349 | G.S6.04 |
Van-der-waals | ICL3 | K | 293 | - | G.S6 | H | 349 | G.S6.04 |
Hydrophobic | ICL2 | S | 201 | 34x50 | G.H5 | L | 371 | G.H5.16 |
Hydrophobic | TM7 | S | 405 | 7x56 | G.H5 | L | 380 | G.H5.25 |
Van-der-waals | TM7 | S | 405 | 7x56 | G.H5 | L | 380 | G.H5.25 |
Polar | C-term | V | 550 | - | G.H3 | K | 284 | G.H3.16 |
Hydrophobic | C-term | V | 550 | - | G.H3 | K | 284 | G.H3.16 |
Van-der-waals | C-term | V | 550 | - | G.H3 | K | 284 | G.H3.16 |
Ionic | C-term | D | 571 | - | H.HA | K | 114 | H.HA.28 |
Polar | C-term | D | 571 | - | H.HA | K | 114 | H.HA.28 |
Hydrophobic | C-term | L | 567 | - | G.s4h3 | D | 264 | G.s4h3.11 |
Hydrophobic | ICL2 | L | 202 | 34x51 | G.H5 | F | 363 | G.H5.08 |
Van-der-waals | ICL2 | L | 202 | 34x51 | G.H5 | F | 363 | G.H5.08 |
Hydrophobic | C-term | C | 556 | - | G.H3 | T | 279 | G.H3.11 |
Van-der-waals | C-term | C | 556 | - | G.H3 | T | 279 | G.H3.11 |
Hydrophobic | C-term | T | 570 | - | H.HA | V | 107 | H.HA.21 |
Van-der-waals | C-term | T | 570 | - | H.HA | V | 107 | H.HA.21 |
Polar | C-term | L | 567 | - | G.s4h3 | R | 265 | G.s4h3.12 |
Hydrophobic | C-term | L | 567 | - | G.s4h3 | R | 265 | G.s4h3.12 |
Hydrophobic | C-term | Y | 559 | - | G.H3 | E | 272 | G.H3.04 |
Polar | C-term | R | 568 | - | G.s4h3 | R | 265 | G.s4h3.12 |
Hydrophobic | C-term | R | 568 | - | G.s4h3 | R | 265 | G.s4h3.12 |
Van-der-waals | C-term | R | 568 | - | G.s4h3 | R | 265 | G.s4h3.12 |
Hydrophobic | C-term | L | 561 | - | G.H2 | R | 232 | G.H2.01 |
Van-der-waals | C-term | L | 561 | - | G.H2 | R | 232 | G.H2.01 |
Hydrophobic | C-term | V | 546 | - | G.H3 | L | 285 | G.H3.17 |
Hydrophobic | TM5 | V | 280 | 5x64 | G.H5 | L | 371 | G.H5.16 |
Hydrophobic | TM3 | V | 198 | 3x54 | G.H5 | I | 378 | G.H5.23 |
Van-der-waals | TM3 | V | 198 | 3x54 | G.H5 | I | 378 | G.H5.23 |
Polar | C-term | C | 533 | - | G.h1ha | R | 83 | G.h1ha.02 |
Van-der-waals | C-term | C | 533 | - | G.h1ha | R | 83 | G.h1ha.02 |
Hydrophobic | TM6 | K | 345 | 6x32 | G.H5 | Q | 381 | G.H5.26 |
Van-der-waals | TM6 | K | 345 | 6x32 | G.H5 | Q | 381 | G.H5.26 |
Hydrophobic | TM5 | V | 277 | 5x61 | G.H5 | I | 378 | G.H5.23 |
Polar | C-term | D | 571 | - | G.s4h3 | R | 265 | G.s4h3.12 |
Van-der-waals | C-term | D | 571 | - | G.s4h3 | R | 265 | G.s4h3.12 |
Hydrophobic | C-term | Y | 559 | - | G.H3 | N | 275 | G.H3.07 |
Van-der-waals | C-term | Y | 559 | - | G.H3 | N | 275 | G.H3.07 |
Polar | TM6 | R | 342 | 6x29 | G.h4s6 | S | 343 | G.h4s6.12 |
Van-der-waals | TM6 | R | 342 | 6x29 | G.h4s6 | S | 343 | G.h4s6.12 |
Polar | TM3 | R | 194 | 3x50 | G.H5 | D | 377 | G.H5.22 |
Hydrophobic | TM3 | R | 194 | 3x50 | G.H5 | D | 377 | G.H5.22 |
Van-der-waals | TM3 | R | 194 | 3x50 | G.H5 | D | 377 | G.H5.22 |
Polar | ICL3 | K | 293 | - | G.S6 | H | 348 | G.S6.03 |
Hydrophobic | ICL3 | K | 293 | - | G.S6 | H | 348 | G.S6.03 |
Van-der-waals | ICL3 | K | 293 | - | G.S6 | H | 348 | G.S6.03 |
Hydrophobic | C-term | S | 543 | - | G.H2 | Q | 240 | G.H2.09 |
Hydrophobic | C-term | I | 572 | - | H.hdhe | F | 173 | H.hdhe.01 |
Hydrophobic | TM5 | L | 288 | 5x72 | G.S6 | F | 347 | G.S6.02 |
Van-der-waals | TM5 | L | 288 | 5x72 | G.S6 | F | 347 | G.S6.02 |
Hydrophobic | ICL2 | L | 202 | 34x51 | G.S3 | I | 221 | G.S3.01 |
Van-der-waals | ICL2 | L | 202 | 34x51 | G.S3 | I | 221 | G.S3.01 |
Hydrophobic | TM5 | L | 288 | 5x72 | G.H5 | Q | 372 | G.H5.17 |
Van-der-waals | TM5 | L | 288 | 5x72 | G.H5 | Q | 372 | G.H5.17 |
Hydrophobic | TM6 | T | 349 | 6x36 | G.H5 | L | 380 | G.H5.25 |
Van-der-waals | TM6 | T | 349 | 6x36 | G.H5 | L | 380 | G.H5.25 |
Polar | C-term | E | 569 | - | H.hdhe | Q | 174 | H.hdhe.02 |
Hydrophobic | C-term | E | 569 | - | H.hdhe | Q | 174 | H.hdhe.02 |
Van-der-waals | C-term | E | 569 | - | H.hdhe | Q | 174 | H.hdhe.02 |
Hydrophobic | C-term | L | 567 | - | G.s4h3 | E | 263 | G.s4h3.10 |
Hydrophobic | TM6 | A | 346 | 6x33 | G.H5 | M | 379 | G.H5.24 |
Van-der-waals | TM6 | A | 346 | 6x33 | G.H5 | M | 379 | G.H5.24 |
Hydrophobic | ICL2 | L | 202 | 34x51 | G.H5 | I | 370 | G.H5.15 |
Van-der-waals | ICL2 | L | 202 | 34x51 | G.H5 | I | 370 | G.H5.15 |
Hydrophobic | ICL3 | E | 295 | - | G.H4 | R | 329 | G.H4.09 |
Van-der-waals | ICL3 | E | 295 | - | G.H4 | R | 329 | G.H4.09 |
Hydrophobic | C-term | E | 569 | - | G.s4h3 | M | 262 | G.s4h3.09 |
Van-der-waals | C-term | E | 569 | - | G.s4h3 | M | 262 | G.s4h3.09 |
Hydrophobic | ICL2 | L | 202 | 34x51 | G.H5 | V | 366 | G.H5.11 |
Hydrophobic | TM5 | A | 281 | 5x65 | G.H5 | L | 375 | G.H5.20 |
Hydrophobic | C-term | I | 572 | - | H.HA | K | 114 | H.HA.28 |
Polar | TM7 | S | 405 | 7x56 | G.H5 | Q | 381 | G.H5.26 |
Hydrophobic | ICL3 | V | 292 | - | G.h4s6 | P | 345 | G.h4s6.20 |