Gi1 -
α1D-adrenoceptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 69.2
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.6
iPTM Score: 0.6
PAE mean: 13.6
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | ICL2 | S | 201 | 34x50 | G.H5 | I | 344 | G.H5.16 |
Van-der-waals | ICL2 | S | 201 | 34x50 | G.H5 | I | 344 | G.H5.16 |
Hydrophobic | TM3 | R | 194 | 3x50 | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | TM3 | R | 194 | 3x50 | G.H5 | C | 351 | G.H5.23 |
Ionic | TM4 | R | 211 | 4x40 | G.HN | D | 20 | G.HN.44 |
Polar | TM4 | R | 211 | 4x40 | G.HN | D | 20 | G.HN.44 |
Hydrophobic | TM4 | R | 211 | 4x40 | G.HN | D | 20 | G.HN.44 |
Van-der-waals | TM4 | R | 211 | 4x40 | G.HN | D | 20 | G.HN.44 |
Hydrophobic | TM3 | V | 198 | 3x54 | G.H5 | L | 348 | G.H5.20 |
Hydrophobic | ICL2 | L | 202 | 34x51 | G.H5 | F | 336 | G.H5.08 |
Hydrophobic | ICL2 | L | 202 | 34x51 | G.H5 | T | 340 | G.H5.12 |
Hydrophobic | C-term | L | 544 | - | G.H1 | K | 54 | G.H1.09 |
Van-der-waals | C-term | L | 544 | - | G.H1 | K | 54 | G.H1.09 |
Aromatic | C-term | Y | 564 | - | G.H2 | H | 213 | G.H2.09 |
Hydrophobic | C-term | Y | 564 | - | G.H2 | H | 213 | G.H2.09 |
Van-der-waals | C-term | Y | 564 | - | G.H2 | H | 213 | G.H2.09 |
Polar | C-term | Y | 564 | - | G.H2 | I | 212 | G.H2.08 |
Hydrophobic | C-term | Y | 564 | - | G.H2 | I | 212 | G.H2.08 |
Van-der-waals | C-term | Y | 564 | - | G.H2 | I | 212 | G.H2.08 |
Hydrophobic | TM6 | K | 345 | 6x32 | G.H5 | G | 352 | G.H5.24 |
Hydrophobic | TM4 | T | 209 | 4x38 | G.HN | E | 28 | G.HN.52 |
Hydrophobic | TM5 | T | 284 | 5x68 | G.H5 | I | 344 | G.H5.16 |
Van-der-waals | TM5 | T | 284 | 5x68 | G.H5 | I | 344 | G.H5.16 |
Hydrophobic | C-term | V | 539 | - | G.S2 | I | 184 | G.S2.01 |
Van-der-waals | C-term | V | 539 | - | G.S2 | I | 184 | G.S2.01 |
Hydrophobic | TM5 | L | 288 | 5x72 | G.H5 | L | 348 | G.H5.20 |
Polar | C-term | S | 537 | - | G.H2 | K | 210 | G.H2.06 |
Hydrophobic | C-term | S | 537 | - | G.H2 | K | 210 | G.H2.06 |
Van-der-waals | C-term | S | 537 | - | G.H2 | K | 210 | G.H2.06 |
Polar | ICL3 | R | 296 | - | G.S6 | I | 319 | G.S6.01 |
Hydrophobic | ICL3 | R | 296 | - | G.S6 | I | 319 | G.S6.01 |
Van-der-waals | ICL3 | R | 296 | - | G.S6 | I | 319 | G.S6.01 |
Hydrophobic | TM5 | L | 288 | 5x72 | G.H5 | K | 345 | G.H5.17 |
Van-der-waals | TM5 | L | 288 | 5x72 | G.H5 | K | 345 | G.H5.17 |
Polar | C-term | L | 561 | - | G.H2 | H | 213 | G.H2.09 |
Hydrophobic | C-term | L | 561 | - | G.H2 | H | 213 | G.H2.09 |
Van-der-waals | C-term | L | 561 | - | G.H2 | H | 213 | G.H2.09 |
Hydrophobic | C-term | L | 544 | - | G.S2 | T | 187 | G.S2.04 |
Van-der-waals | C-term | L | 544 | - | G.S2 | T | 187 | G.S2.04 |
Polar | C-term | E | 540 | - | G.S2 | I | 184 | G.S2.01 |
Polar | C-term | I | 572 | - | G.H3 | S | 252 | G.H3.11 |
Hydrophobic | C-term | I | 572 | - | G.H3 | S | 252 | G.H3.11 |
Van-der-waals | C-term | I | 572 | - | G.H3 | S | 252 | G.H3.11 |
Polar | TM3 | G | 197 | 3x53 | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | TM3 | G | 197 | 3x53 | G.H5 | N | 347 | G.H5.19 |
Van-der-waals | TM3 | G | 197 | 3x53 | G.H5 | N | 347 | G.H5.19 |
Polar | TM6 | T | 349 | 6x36 | G.H5 | G | 352 | G.H5.24 |
Hydrophobic | TM6 | T | 349 | 6x36 | G.H5 | G | 352 | G.H5.24 |
Van-der-waals | TM6 | T | 349 | 6x36 | G.H5 | G | 352 | G.H5.24 |
Hydrophobic | ICL2 | A | 206 | 34x55 | G.hns1 | R | 32 | G.hns1.03 |
Van-der-waals | ICL2 | A | 206 | 34x55 | G.hns1 | R | 32 | G.hns1.03 |
Hydrophobic | TM5 | A | 281 | 5x65 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | TM3 | V | 198 | 3x54 | G.H5 | L | 353 | G.H5.25 |
Polar | TM7 | S | 405 | 7x56 | G.H5 | D | 350 | G.H5.22 |
Van-der-waals | TM7 | S | 405 | 7x56 | G.H5 | D | 350 | G.H5.22 |
Hydrophobic | C-term | I | 572 | - | G.H2 | R | 208 | G.H2.04 |
Van-der-waals | C-term | I | 572 | - | G.H2 | R | 208 | G.H2.04 |
Hydrophobic | TM7 | S | 405 | 7x56 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | TM5 | V | 277 | 5x61 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM5 | V | 277 | 5x61 | G.H5 | L | 353 | G.H5.25 |
Ionic | ICL3 | E | 295 | - | G.S6 | H | 322 | G.S6.04 |
Polar | ICL2 | S | 201 | 34x50 | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | ICL2 | S | 201 | 34x50 | G.H5 | N | 347 | G.H5.19 |
Van-der-waals | ICL2 | S | 201 | 34x50 | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | TM6 | L | 350 | 6x37 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM6 | L | 350 | 6x37 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | ICL2 | L | 202 | 34x51 | G.H5 | I | 343 | G.H5.15 |
Van-der-waals | ICL2 | L | 202 | 34x51 | G.H5 | I | 343 | G.H5.15 |
Hydrophobic | TM5 | L | 288 | 5x72 | G.H5 | F | 354 | G.H5.26 |
Hydrophobic | ICL3 | V | 292 | - | G.h4s6 | E | 318 | G.h4s6.12 |
Van-der-waals | ICL3 | V | 292 | - | G.h4s6 | E | 318 | G.h4s6.12 |
Hydrophobic | ICL2 | A | 206 | 34x55 | G.HN | E | 28 | G.HN.52 |
Van-der-waals | ICL2 | A | 206 | 34x55 | G.HN | E | 28 | G.HN.52 |
Hydrophobic | ICL2 | P | 205 | 34x54 | G.hns1 | A | 31 | G.hns1.02 |
Van-der-waals | ICL2 | P | 205 | 34x54 | G.hns1 | A | 31 | G.hns1.02 |
Polar | ICL3 | R | 330 | - | G.h4s6 | K | 314 | G.h4s6.08 |
Ionic | ICL3 | R | 296 | - | G.h4s6 | E | 318 | G.h4s6.12 |
Polar | ICL3 | R | 296 | - | G.h4s6 | E | 318 | G.h4s6.12 |
Hydrophobic | ICL3 | E | 295 | - | G.H5 | F | 334 | G.H5.06 |
Van-der-waals | ICL3 | E | 295 | - | G.H5 | F | 334 | G.H5.06 |
Hydrophobic | C-term | L | 561 | - | G.H2 | K | 210 | G.H2.06 |
Hydrophobic | C-term | I | 572 | - | G.H3 | I | 253 | G.H3.12 |
Hydrophobic | TM4 | K | 212 | 4x41 | G.HN | R | 24 | G.HN.48 |
Ionic | ICL3 | R | 296 | - | G.H4 | E | 308 | G.H4.16 |
Polar | ICL3 | R | 296 | - | G.H4 | E | 308 | G.H4.16 |
Hydrophobic | ICL3 | R | 296 | - | G.H4 | E | 308 | G.H4.16 |
Van-der-waals | ICL3 | R | 296 | - | G.H4 | E | 308 | G.H4.16 |
Hydrophobic | C-term | L | 567 | - | G.H2 | I | 212 | G.H2.08 |
Van-der-waals | C-term | L | 567 | - | G.H2 | I | 212 | G.H2.08 |
Hydrophobic | TM5 | A | 281 | 5x65 | G.H5 | L | 348 | G.H5.20 |
Van-der-waals | TM5 | A | 281 | 5x65 | G.H5 | L | 348 | G.H5.20 |
Hydrophobic | TM5 | T | 284 | 5x68 | G.H5 | L | 348 | G.H5.20 |
Polar | TM6 | A | 346 | 6x33 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | TM6 | A | 346 | 6x33 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM6 | A | 346 | 6x33 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | ICL2 | S | 201 | 34x50 | G.H5 | I | 343 | G.H5.15 |
Hydrophobic | ICL2 | L | 202 | 34x51 | G.S3 | L | 194 | G.S3.01 |
Hydrophobic | TM5 | L | 288 | 5x72 | G.H5 | D | 341 | G.H5.13 |
Van-der-waals | TM5 | L | 288 | 5x72 | G.H5 | D | 341 | G.H5.13 |
Aromatic | TM6 | R | 342 | 6x29 | G.H5 | F | 354 | G.H5.26 |
Hydrophobic | TM6 | R | 342 | 6x29 | G.H5 | F | 354 | G.H5.26 |
Van-der-waals | TM6 | R | 342 | 6x29 | G.H5 | F | 354 | G.H5.26 |
Hydrophobic | TM3 | V | 198 | 3x54 | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | TM3 | V | 198 | 3x54 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | C-term | I | 572 | - | G.H2 | I | 212 | G.H2.08 |
Polar | TM6 | K | 345 | 6x32 | G.H5 | F | 354 | G.H5.26 |
Hydrophobic | TM6 | K | 345 | 6x32 | G.H5 | F | 354 | G.H5.26 |
Van-der-waals | TM6 | K | 345 | 6x32 | G.H5 | F | 354 | G.H5.26 |
Hydrophobic | C-term | I | 572 | - | G.H2 | W | 211 | G.H2.07 |
Ionic | ICL2 | K | 203 | 34x52 | G.s2s3 | D | 193 | G.s2s3.02 |
Polar | ICL2 | K | 203 | 34x52 | G.s2s3 | D | 193 | G.s2s3.02 |
Hydrophobic | ICL2 | K | 203 | 34x52 | G.s2s3 | D | 193 | G.s2s3.02 |
Van-der-waals | ICL2 | K | 203 | 34x52 | G.s2s3 | D | 193 | G.s2s3.02 |
Hydrophobic | C-term | L | 544 | - | G.h1ha | E | 58 | G.h1ha.01 |
Van-der-waals | C-term | L | 544 | - | G.h1ha | E | 58 | G.h1ha.01 |
Hydrophobic | TM5 | L | 288 | 5x72 | G.H5 | I | 344 | G.H5.16 |
Hydrophobic | TM5 | T | 285 | 5x69 | G.H5 | F | 354 | G.H5.26 |
Hydrophobic | C-term | W | 431 | - | G.H2 | H | 213 | G.H2.09 |
Van-der-waals | C-term | W | 431 | - | G.H2 | H | 213 | G.H2.09 |
Ionic | H8 | R | 411 | 8x52 | G.h3s5 | D | 261 | G.h3s5.02 |
Polar | H8 | R | 411 | 8x52 | G.h3s5 | D | 261 | G.h3s5.02 |
Hydrophobic | TM7 | S | 405 | 7x56 | G.H5 | G | 352 | G.H5.24 |
Van-der-waals | TM7 | S | 405 | 7x56 | G.H5 | G | 352 | G.H5.24 |